Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
abParts	0	broad.mit.edu	37	14	106622158	106622158	+	RNA	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr14:106622158G>A	uc021ser.1	-	1605		c.31154C>T								Parts of antibodies, mostly variable regions.																		GCTGTACCAAGCCTCCCCCAG	0.567000														77			3		0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16976896	16976896	+	RNA	SNP	A	G	G	rs149376405	by1000genomes	TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr1:16976896A>G	uc010och.2	+	13		c.2617A>G			MST1P2_uc009vox.3_Non-coding_Transcript|MST1P2_uc001azm.4_Non-coding_Transcript					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		aaacagtaataaagaagagaa	0.328000														27			3		0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144765015	144765015	+	Silent	SNP	A	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr2:144765015A>G	uc002tvp.3	-	6	888	c.609T>C	c.(607-609)ccT>ccC	p.P203P	GTDC1_uc002tvo.3_Silent_p.P203P|GTDC1_uc021vqf.1_Silent_p.P203P|GTDC1_uc010fnn.3_Silent_p.P203P|GTDC1_uc002tvs.3_Silent_p.P171P|GTDC1_uc021vqg.1_Intron|GTDC1_uc002tvr.3_Silent_p.P203P|GTDC1_uc010fno.3_Silent_p.P74P|GTDC1_uc002tvt.2_Silent_p.P203P	NM_001006636	NP_001158101	Q4AE62	GTDC1_HUMAN	Homo sapiens glycosyltransferase-like domain containing 1 (GTDC1), transcript variant 1, mRNA.	203					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		CTGGCTGAAAAGGAAGGGCCA	0.423000														69			4		0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851659	97851659	+	Missense_Mutation	SNP	A	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr3:97851659A>T	uc011bgt.2	+	0	118	c.118A>T	c.(118-120)Atg>Ttg	p.M40L		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily H, member 1 (OR5H1), mRNA.	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M40L(6)|p.M40I(4)		breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						CATCACCATCATGGGGAATCT	0.413000														208			6		0	0	1	0	0
ARSD	414	broad.mit.edu	37	X	2827911	2827911	+	Missense_Mutation	SNP	C	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chrX:2827911C>G	uc004cqy.3	-	7	1345	c.1245G>C	c.(1243-1245)atG>atC	p.M415I		NM_001669	NP_001660	P51689	ARSD_HUMAN	Homo sapiens arylsulfatase D (ARSD), mRNA.	415						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAACACGTCCATCAGGCTCG	0.612000														56			87		0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100595075	100595075	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr14:100595075G>T	uc001ygu.3	+	5	794	c.707G>T	c.(706-708)aGa>aTa	p.R236I	EVL_uc001ygt.3_Missense_Mutation_p.R234I|EVL_uc001ygv.2_Missense_Mutation_p.R240I	NM_016337	NP_057421	Q9UI08	EVL_HUMAN	Homo sapiens Enah/Vasp-like (EVL), mRNA.	234	EVH2 block A.|EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	SH3 domain binding|actin binding|profilin binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				AAGCTGAGAAGAGTCCAACGG	0.657000														69			16		5.35267e-07	5.48991e-07	1	1	0
GPR124	25960	broad.mit.edu	37	8	37688272	37688272	+	Missense_Mutation	SNP	C	T	T	rs144591273		TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr8:37688272C>T	uc003xkj.3	+	6	1149	c.763C>T	c.(763-765)Cgc>Tgc	p.R255C	GPR124_uc010lvy.3_Missense_Mutation_p.R255C	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	Homo sapiens G protein-coupled receptor 124 (GPR124), mRNA.	255	Ig-like.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCCGTCCCTACGCCAAGTGGT	0.657000														86			53		0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18245714	18245714	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr19:18245714G>A	uc002nhz.4	+	15	1705	c.1705G>A	c.(1705-1707)Gtc>Atc	p.V569I		NM_015016	NP_055831	O60307	MAST3_HUMAN	Homo sapiens microtubule associated serine/threonine kinase 3 (MAST3), mRNA.	569	Protein kinase.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						CATGGGCGTCGTCCTCTATGA	0.632000														309			5		0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66500864	66500864	+	RNA	SNP	A	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr9:66500864A>G	uc004aed.1	+	2		c.957A>G								Homo sapiens uncharacterized LOC442421 (LOC442421), non-coding RNA.																		GAGCACCTACACGGAACTGCT	0.602000														9			4		0	0	1	0	0
SETD1B	23067	broad.mit.edu	37	12	122260719	122260719	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr12:122260719G>T	uc001ubi.3	+	11	4111	c.4105G>T	c.(4105-4107)Gcc>Tcc	p.A1369S	SETD1B_uc021rfg.1_Missense_Mutation_p.A1412S	NM_015048	NP_055863	Q9UPS6	SET1B_HUMAN	Homo sapiens SET domain containing 1B (SETD1B), mRNA.	1369	Pro-rich.				histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Set1C/COMPASS complex|chromosome|nuclear speck	RNA binding|histone-lysine N-methyltransferase activity|nucleotide binding|protein binding			NS(1)|endometrium(6)|kidney(2)|prostate(2)	11						CTCCTACCCAGCCCCGTCCCC	0.701000														54			24		1.77063e-15	1.86382e-15	1	1	0
CCDC135	84229	broad.mit.edu	37	16	57760055	57760055	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr16:57760055G>A	uc002emi.3	+	12	1923	c.1834G>A	c.(1834-1836)Gcg>Acg	p.A612T	CCDC135_uc002emj.3_Missense_Mutation_p.A612T|CCDC135_uc002emk.3_Missense_Mutation_p.A547T	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	Homo sapiens coiled-coil domain containing 135 (CCDC135), mRNA.	612						cytoplasm		p.A612T(2)		breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GTTTCTGGTCGCGGAGGAGCG	0.632000														171			5		0	0	1	0	0
GOLGA6L6	727832	broad.mit.edu	37	15	20740040	20740040	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr15:20740040A>C	uc001ytk.2	-	7	1801	c.1710T>G	c.(1708-1710)gaT>gaG	p.D570E	DQ594309_uc010tzb.1_5'Flank	NM_001145004	NP_001138476	A8MZA4	GG6L6_HUMAN	Homo sapiens golgin A6 family-like 6 (GOLGA6L6), mRNA.	570	Gln-rich.|Glu-rich.							p.D570E(4)		NS(3)|endometrium(4)|kidney(1)|skin(3)	11						tccacatcttatcctcctgct	0.562000														128			7		0	0	1	0	0
FBL	2091	broad.mit.edu	37	19	40331124	40331124	+	Silent	SNP	A	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr19:40331124A>G	uc002omn.3	-	2	327	c.213T>C	c.(211-213)ggT>ggC	p.G71G	FBL_uc002omm.1_5'UTR|FBL_uc002omo.2_Silent_p.G70G|FBL_uc010egr.3_Silent_p.G71G	NM_001436	NP_001427	P22087	FBRL_HUMAN	Homo sapiens fibrillarin (FBL), mRNA.	71	DMA/Gly-rich.				rRNA processing|tRNA processing	Cajal body|box C/D snoRNP complex	RNA binding|methyltransferase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CCCGACCACGACCCCGGTTGC	0.587000														69			5		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118490	118490	+	RNA	SNP	G	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chrGL000205.1:118490G>T	uc002kgk.4	+	0		c.1868G>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		AGCAGAGAATGCCGGAAGGTA	0.463000														35			4		0.00909568	0.00909568	1	1	0
MYADML2	255275	broad.mit.edu	37	17	79899490	79899490	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr17:79899490C>T	uc010wvf.1	-	2	483	c.128G>A	c.(127-129)cGg>cAg	p.R43Q	MYADML2_uc021ufi.1_Missense_Mutation_p.R43Q	NM_001145113	NP_001138585	A6NDP7	MADL2_HUMAN	Homo sapiens myeloid-associated differentiation marker-like 2 (MYADML2), mRNA.	43	MARVEL 1.					integral to membrane				endometrium(1)	1						AAAGCCACCCCGGTGGGCCAC	0.687000														17			44		0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218713275	218713275	+	Silent	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr2:218713275C>T	uc002vgt.2	-	16	1988	c.1590G>A	c.(1588-1590)gaG>gaA	p.E530E	TNS1_uc002vgr.2_Silent_p.E530E|TNS1_uc002vgs.2_Silent_p.E530E|TNS1_uc010zjv.1_Silent_p.E530E|TNS1_uc010fvj.1_Silent_p.E598E|TNS1_uc010fvk.1_Silent_p.E655E|TNS1_uc010fvi.1_Silent_p.E217E	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	Homo sapiens tensin 1 (TNS1), mRNA.	530						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTAGCCCCCCTCACTGGTGT	0.592000														92			3		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195510066	195510066	+	Silent	SNP	T	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr3:195510066T>G	uc021xjp.1	-	1	8541	c.8385A>C	c.(8383-8385)acA>acC	p.T2795T	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	531					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGTGTGACCTGTGGATGCTG	0.592000														70			6		0	0	1	0	0
CHCHD2	51142	broad.mit.edu	37	7	56172050	56172050	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr7:56172050C>T	uc003tsa.3	-	1	250	c.169G>A	c.(169-171)Gcc>Acc	p.A57T	PSPH_uc003trj.3_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), nuclear gene encoding mitochondrial protein, mRNA.	57						mitochondrion				endometrium(1)|large_intestine(1)|lung(3)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCCATCTGGGCCATCAGACCT	0.647000														101			4		0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53762250	53762250	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr19:53762250T>C	uc002qbi.2	+	0	706	c.622T>C	c.(622-624)Tac>Cac	p.Y208H		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	Homo sapiens vomeronasal 1 receptor 2 (VN1R2), mRNA.	208					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AGCCCCGACATACATTGGTCT	0.473000														71			3		0	0	1	0	0
LOC440041	440041	broad.mit.edu	37	11	55061186	55061186	+	RNA	SNP	A	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr11:55061186A>G	uc021qjb.1	-	4		c.1000T>C			LOC440041_uc001nhl.1_Non-coding_Transcript					Homo sapiens SPRY domain containing 5 pseudogene (LOC440041), non-coding RNA.																		CCTGCACTGAAATCTGGATTC	0.448000														132			4		0	0	1	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2485	2485	+	RNA	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chrGL000237.1:2485C>T	uc011mgu.1	-	0		c.202G>A								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		ctccggctgccatcttactgc	0.627000														11			4		0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219350461	219350461	+	Silent	SNP	T	C	C			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr2:219350461T>C	uc010fvs.1	-	15	2009	c.1596A>G	c.(1594-1596)gaA>gaG	p.E532E	USP37_uc002vie.2_Silent_p.E532E|USP37_uc010zkf.1_Silent_p.E532E|USP37_uc002vif.2_Silent_p.E532E|USP37_uc002vig.2_Silent_p.E460E	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	Homo sapiens ubiquitin specific peptidase 37 (USP37), mRNA.	532					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		ACTCCAGTTCTTCGGCCTATA	0.333000														105			4		0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41121543	41121543	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr6:41121543C>T	uc011duc.2	-	1	373	c.329G>A	c.(328-330)aGg>aAg	p.R110K	TREML1_uc003opx.3_Missense_Mutation_p.R110K|TREML1_uc011dud.2_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	Homo sapiens triggering receptor expressed on myeloid cells-like 1 (TREML1), mRNA.	110	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity	p.R110K(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTGGGGCCCCCTGGCCCCATC	0.602000														81			3		0	0	1	0	0
FAM189B	10712	broad.mit.edu	37	1	155224214	155224214	+	Missense_Mutation	SNP	A	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr1:155224214A>T	uc001fjm.3	-	1	865	c.259T>A	c.(259-261)Tgg>Agg	p.W87R	FAM189B_uc009wql.3_5'Flank|FAM189B_uc001fjn.3_Intron|FAM189B_uc001fjo.3_Intron|FAM189B_uc001fjp.3_Intron|FAM189B_uc001fjq.1_Missense_Mutation_p.W87R	NM_006589	NP_006580	P81408	F189B_HUMAN	Homo sapiens family with sequence similarity 189, member B (FAM189B), transcript variant 1, mRNA.	87						integral to membrane	WW domain binding			breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23						GGCCGCTTCCAGGACACAATG	0.632000														15			53		0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76029194	76029194	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr5:76029194G>A	uc003ken.4	+	1	1409	c.1144G>A	c.(1144-1146)Gtc>Atc	p.V382I		NM_001992	NP_001983	P25116	PAR1_HUMAN	Homo sapiens coagulation factor II (thrombin) receptor (F2R), mRNA.	382					STAT protein import into nucleus|activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|tyrosine phosphorylation of STAT protein	Golgi apparatus|caveola|extracellular region|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	CCAGAGGTACGTCTACAGTAT	0.473000														177			4		0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140736273	140736273	+	Silent	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr5:140736273C>T	uc003ljq.2	+	0	1506	c.1506C>T	c.(1504-1506)tcC>tcT	p.S502S	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljp.1_Silent_p.S502S	NM_018917	NP_061740	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 4 (PCDHGA4), transcript variant 1, mRNA.	504	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTCTGTCCTCCTATGTCT	0.512000														68			51		0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13828724	13828724	+	Silent	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr12:13828724C>T	uc001rbt.2	-	3	1259	c.1080G>A	c.(1078-1080)ccG>ccA	p.P360P		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA.	360					response to ethanol	N-methyl-D-aspartate selective glutamate receptor complex|cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|glycine binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCACCAGTTTCGGGTGCATCT	0.373000														114			98		0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53169330	53169330	+	Silent	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr12:53169330C>T	uc001sax.3	-	1	711	c.657G>A	c.(655-657)caG>caA	p.Q219Q		NM_015848	NP_056932	Q01546	K22O_HUMAN	Homo sapiens keratin 76 (KRT76), mRNA.	219	Linker 1.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGGTCTGCTGCTGGAGCAGTT	0.557000														67			3		0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56335069	56335069	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr12:56335069G>A	uc001sij.3	+	13	1399	c.1135G>A	c.(1135-1137)Gtc>Atc	p.V379I	DGKA_uc001sih.1_Missense_Mutation_p.V267I|DGKA_uc001sii.1_Missense_Mutation_p.V237I|DGKA_uc009zod.1_Missense_Mutation_p.V298I|DGKA_uc001sik.3_Missense_Mutation_p.V379I|DGKA_uc001sil.3_Missense_Mutation_p.V379I|DGKA_uc001sim.3_Missense_Mutation_p.V379I|DGKA_uc001sin.3_Missense_Mutation_p.V379I|DGKA_uc009zof.3_Missense_Mutation_p.V25I|DGKA_uc001sio.3_Missense_Mutation_p.V121I	NM_001345	NP_963848	P23743	DGKA_HUMAN	Homo sapiens diacylglycerol kinase, alpha 80kDa (DGKA), transcript variant 3, mRNA.	379	DAGKc.			V -> L (in Ref. 2; AAC34802).	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.V379I(2)		breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	CCCACTTCTCGTCTTTGTCAA	0.493000														37			6		0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31621476	31621476	+	Silent	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr2:31621476G>A	uc002rnv.1	-	4	475	c.396C>T	c.(394-396)ccC>ccT	p.P132P		NM_000379	NP_000370	P47989	XDH_HUMAN	Homo sapiens xanthine dehydrogenase (XDH), mRNA.	132					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGGTGGGCTCGGGCTGATTCC	0.567000														17			61		0	0	1	0	0
CPPED1	55313	broad.mit.edu	37	16	12798816	12798816	+	Missense_Mutation	SNP	T	A	A	rs3748982		TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr16:12798816T>A	uc002dca.4	-	2	491	c.380A>T	c.(379-381)aAc>aTc	p.N127I	CPPED1_uc002dcb.4_Intron	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	Homo sapiens calcineurin-like phosphoesterase domain containing 1 (CPPED1), transcript variant 1, mRNA.	127							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						AATGTCATGGTTGCCGCTGAC	0.627000														36			22		0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134145788	134145788	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr8:134145788G>A	uc003ytw.3	+	46	8113	c.8072G>A	c.(8071-8073)cGt>cAt	p.R2691H	TG_uc010mdw.3_Missense_Mutation_p.R1450H|TG_uc011ljb.2_Missense_Mutation_p.R1060H|TG_uc011ljc.2_Missense_Mutation_p.R824H	NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	2691					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTTGTACCCCGTGCTGGTGGA	0.502000														99			72		0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52505118	52505118	+	Silent	SNP	T	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr19:52505118T>G	uc002pyf.2	-	4	503	c.186A>C	c.(184-186)cgA>cgC	p.R62R	ZNF615_uc002pye.2_Silent_p.R62R|ZNF615_uc002pyh.2_Silent_p.R62R|ZNF615_uc010epi.2_Silent_p.R58R|ZNF615_uc002pyg.2_5'UTR|ZNF615_uc010ydg.2_Silent_p.R67R	NM_001199324	NP_001186253	Q8N8J6	ZN615_HUMAN	Homo sapiens zinc finger protein 615 (ZNF615), transcript variant 1, mRNA.	62	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TTTCTTCTCCTCGTTCCAATT	0.463000														74			71		0	0	1	0	0
LCAT	3931	broad.mit.edu	37	16	67974324	67974324	+	Missense_Mutation	SNP	A	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr16:67974324A>T	uc002euy.1	-	5	817	c.806T>A	c.(805-807)aTa>aAa	p.I269K		NM_000229	NP_000220	P04180	LCAT_HUMAN	Homo sapiens lecithin-cholesterol acyltransferase (LCAT), mRNA.	269					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity			cervix(4)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		GGTGGTGGTTATGCGCTGCTC	0.582000														117			62		0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10629266	10629266	+	Silent	SNP	A	G	G			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr20:10629266A>G	uc002wnw.2	-	11	2016	c.1500T>C	c.(1498-1500)ggT>ggC	p.G500G	JAG1_uc010gcd.1_Silent_p.G58G	NM_000214	NP_000205	P78504	JAG1_HUMAN	Homo sapiens jagged 1 (JAG1), mRNA.	500	EGF-like 8; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	Notch binding|calcium ion binding|growth factor activity|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						TCTGACAGTGACCCCCATTCA	0.498000									Alagille Syndrome					130			4		0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	11012928	11012928	+	RNA	SNP	A	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr21:11012928A>T	uc002yis.1	-	8		c.1693T>A						P56180	TPTE_HUMAN	Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 2, mRNA.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGCTTTTTTACTTTTGTGAC	0.294000														34			5		0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39535652	39535652	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr17:39535652G>A	uc002hwm.3	-	4	967	c.955C>T	c.(955-957)Cgc>Tgc	p.R319C		NM_021013	NP_066293	O76011	KRT34_HUMAN	Homo sapiens keratin 34 (KRT34), mRNA.	319	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				TTGACTGTGCGTCTCAGCTCG	0.582000														15			39		0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28604440	28604440	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr18:28604440G>T	uc002kwj.4	-	5	805	c.650C>A	c.(649-651)aCt>aAt	p.T217N	DSC3_uc002kwi.4_Missense_Mutation_p.T217N	NM_001941	NP_001932	Q14574	DSC3_HUMAN	Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.	217	Cadherin 1.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding	p.S216*(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TCCATCTGCAGTTGACGCATA	0.403000														48			38		1.06522e-23	1.15159e-23	1	1	0
ARHGAP33	115703	broad.mit.edu	37	19	36278799	36278799	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr19:36278799C>T	uc002obs.2	+	20	2993	c.2849C>T	c.(2848-2850)cCc>cTc	p.P950L	ARHGAP33_uc002obt.2_Missense_Mutation_p.P947L|ARHGAP33_uc002obv.1_Missense_Mutation_p.P699L	NM_052948	NP_443180	O14559	RHG33_HUMAN	Homo sapiens Rho GTPase activating protein 33 (ARHGAP33), transcript variant 1, mRNA.	1111					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CGCTCCATGCCCCCCGACAGG	0.647000														55			3		0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52913573	52913573	+	Missense_Mutation	SNP	C	T	T	rs59115483		TCGA-KO-8415-01A-11D-2310-10	TCGA-KO-8415-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebde5c33-4b0f-4c3d-bf45-52b2d54093ec	6ae02049-78de-46c7-af90-146bd04cb94e	g.chr12:52913573C>T	uc001san.3	-	0	671	c.508G>A	c.(508-510)Gag>Aag	p.E170K	KRT5_uc009zmh.3_Missense_Mutation_p.E170K	NM_000424	NP_000415	P13647	K2C5_HUMAN	Homo sapiens keratin 5 (KRT5), mRNA.	170	Coil 1A.|Rod.		E -> K (in K-EBS; dbSNP:rs59115483).		epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		TTGATCTGCTCGCGCTCCTCG	0.498000														83			74		0	0	1	0	0
