Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLK	9748	broad.mit.edu	37	10	105727558	105727558	+	Missense_Mutation	SNP	A	C	C	rs137997569	byFrequency	TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr10:105727558A>C	uc001kxo.1	+	0	89	c.55A>C	c.(55-57)Aag>Cag	p.K19Q	SLK_uc001kxp.1_Missense_Mutation_p.K19Q	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	Homo sapiens STE20-like kinase (SLK), mRNA.	19	Poly-Lys.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAAGAAGAAGAAGCAGTACGA	0.458000														29			7		0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77477838	77477838	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr18:77477838C>T	uc002lnh.2	+	9	2386	c.2239C>T	c.(2239-2241)Cgg>Tgg	p.R747W	CTDP1_uc002lni.2_Missense_Mutation_p.R747W|CTDP1_uc010drd.2_Missense_Mutation_p.R747W|CTDP1_uc021ult.1_Missense_Mutation_p.R628W	NM_004715	NP_001189433	Q9Y5B0	CTDP1_HUMAN	Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1), transcript variant 1, mRNA.	747					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CTTTCCCGACCGGGAGGGTGT	0.667000														72			3		0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	GL000192.1	311414	311414	+	RNA	SNP	T	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chrGL000192.1:311414T>C	uc010yij.1	-	6		c.955A>G			HYDIN_uc021vdl.1_Non-coding_Transcript	NM_017558		Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 2, mRNA.											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CGTATTTCTGTACAGTGTTGG	0.532000														17			3		0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578208	7578208	+	Missense_Mutation	SNP	T	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr17:7578208T>A	uc002gim.2	-	5	835	c.641A>T	c.(640-642)cAt>cTt	p.H214L	TP53_uc002gig.1_Missense_Mutation_p.H214L|TP53_uc002gih.3_Missense_Mutation_p.H214L|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Missense_Mutation_p.H82L|TP53_uc010cnf.1_Missense_Mutation_p.H82L|TP53_uc002gii.1_Missense_Mutation_p.H82L|TP53_uc010cni.1_Missense_Mutation_p.H214L|TP53_uc010cnh.1_Missense_Mutation_p.H214L|TP53_uc002gij.2_Missense_Mutation_p.H214L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H121L|TP53_uc002gio.2_Missense_Mutation_p.H82L|TP53_uc010vug.2_Missense_Mutation_p.H175L|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	214	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> P (in a sporadic cancer; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(217)|p.H214R(114)|p.R213L(35)|p.R213Q(27)|p.R213fs*34(10)|p.H214fs*33(8)|p.0?(8)|p.R213P(5)|p.H214Y(5)|p.?(5)|p.R213R(4)|p.H214D(4)|p.H214Q(4)|p.H214fs*5(4)|p.H121R(4)|p.H82R(4)|p.R213G(3)|p.D208_V216delDRNTFRHSV(2)|p.T211_S215delTFRHS(2)|p.R213_S215>X(2)|p.D207_V216del10(2)|p.R213fs*32(2)|p.K164_P219del(1)|p.H214fs*7(1)|p.H214_S215insX(1)|p.H82fs*>9(1)|p.D207_R213delDDRNTFR(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.H121fs*33(1)|p.R213fs*2(1)|p.H214H(1)|p.R209_R213delRNTFR(1)|p.R209fs*6(1)|p.T211fs*28(1)|p.R213fs*35(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACCACACTATGTCGAAAAGT	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)				47			3		0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839010	15839010	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr19:15839010C>T	uc002nbm.2	+	0	177	c.157C>T	c.(157-159)Cgc>Tgc	p.R53C		NM_013939	NP_039227	O60403	O10H2_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily H, member 2 (OR10H2), mRNA.	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CTGGAGCGAGCGCAGCCTCCA	0.612000														119			57		0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114569	27114569	+	Silent	SNP	T	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr6:27114569T>C	uc003nix.2	-	0	69	c.9A>G	c.(7-9)gaA>gaG	p.E3E	Histone3_uc021yox.1_5'Flank|HIST1H2BK_uc021yoy.1_Silent_p.E3E|HIST1H2AH_uc003niz.3_5'Flank|MIR3143_uc021yoz.1_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	Homo sapiens histone cluster 1, H2bk (HIST1H2BK), mRNA.	3					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding	p.P2L(1)		breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						ACTTCGCTGGTTCCGGCATGT	0.562000														32			5		0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017180	1017180	+	Missense_Mutation	SNP	G	A	A	rs71472140		TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr11:1017180G>A	uc001lsw.2	-	30	5672	c.5621C>T	c.(5620-5622)aCa>aTa	p.T1874I		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	Homo sapiens mucin 6, oligomeric mucus/gel-forming (MUC6), mRNA.	1874	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AATGGTGCCTGTTGGCATTGA	0.582000														166			10		0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120662127	120662127	+	Missense_Mutation	SNP	C	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr12:120662127C>A	uc001txv.3	-	1	209	c.67G>T	c.(67-69)Gtg>Ttg	p.V23L	PXN_uc001txx.3_5'UTR|PXN_uc001txt.3_Missense_Mutation_p.V23L|PXN_uc001txy.3_Missense_Mutation_p.V23L|PXN_uc001txz.3_Non-coding_Transcript	NM_001243756	NP_001230685	P49023	PAXI_HUMAN	Homo sapiens paxillin (PXN), transcript variant 3, mRNA.	23					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding	p.P22L(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACAAGAACACAGGCCGTTTG	0.622000														75			4		8.12818e-05	8.40847e-05	1	1	0
C5orf44	80006	broad.mit.edu	37	5	64942924	64942924	+	Missense_Mutation	SNP	T	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr5:64942924T>A	uc003jua.4	+	4	673	c.343T>A	c.(343-345)Tcc>Acc	p.S115T	C5orf44_uc003jtz.4_Missense_Mutation_p.S115T|C5orf44_uc010iwv.3_Missense_Mutation_p.S115T|C5orf44_uc003juc.4_Missense_Mutation_p.S115T	NM_001093755	NP_001087224	A5PLN9	CE044_HUMAN	Homo sapiens chromosome 5 open reading frame 44 (C5orf44), transcript variant 1, mRNA.	115										kidney(4)|large_intestine(2)|lung(1)|ovary(1)	8						TCTTTCAGCCTCCAATGCTGC	0.358000														140			15		0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328442	80328442	+	Missense_Mutation	SNP	C	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr4:80328442C>A	uc003hlu.3	-	0	931	c.913G>T	c.(913-915)Gct>Tct	p.A305S		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	Homo sapiens glycerol kinase 2 (GK2), mRNA.	305					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						AGTTTGTAAGCTACTGTGGTC	0.438000														168			9		0.000673444	0.000673444	1	1	0
ZNF319	57567	broad.mit.edu	37	16	58030679	58030679	+	Silent	SNP	G	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr16:58030679G>A	uc002emx.1	-	1	2114	c.1491C>T	c.(1489-1491)taC>taT	p.Y497Y	ZNF319_uc021tjd.1_Silent_p.Y497Y	NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	Homo sapiens zinc finger protein 319 (ZNF319), mRNA.	497					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						GGTCTGACGCGTACTTGAAGC	0.617000														43			4		0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57970779	57970779	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr11:57970779G>A	uc010rkb.2	-	0	875	c.875C>T	c.(874-876)aCt>aTt	p.T292I		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	Homo sapiens olfactory receptor, family 1, subfamily S, member 2 (OR1S2), mRNA.	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				TGTCACCACAGTGAATAGGAC	0.448000														99			6		0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94253666	94253666	+	Missense_Mutation	SNP	G	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr5:94253666G>C	uc003kkx.2	-	7	1285	c.1285C>G	c.(1285-1287)Cca>Gca	p.P429A	MCTP1_uc003kkv.2_Missense_Mutation_p.P208A|MCTP1_uc003kkw.2_Intron|MCTP1_uc003kkz.2_Missense_Mutation_p.P90A|MCTP1_uc003kku.2_Intron	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	Homo sapiens multiple C2 domains, transmembrane 1 (MCTP1), transcript variant L, mRNA.	429					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding	p.R428R(1)		breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GGAAGAGCTGGCCTGCCGCAC	0.428000														79			7		0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50045190	50045190	+	Silent	SNP	A	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr12:50045190A>T	uc001ruv.1	-	14	1881	c.1647T>A	c.(1645-1647)tcT>tcA	p.S549S	FMNL3_uc001ruw.1_Silent_p.S498S|FMNL3_uc001rut.1_Silent_p.S115S|FMNL3_uc001ruu.1_Silent_p.S399S	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	Homo sapiens formin-like 3 (FMNL3), transcript variant 1, mRNA.	549					actin cytoskeleton organization		Rho GTPase binding|actin binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TCAACACCACAGAGGGTGCAG	0.607000														50			4		0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263627	119263627	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr3:119263627C>T	uc003ecq.3	-	2	583	c.188G>A	c.(187-189)cGc>cAc	p.R63H	CD80_uc010hqt.1_Missense_Mutation_p.R63H|CD80_uc010hqu.1_Missense_Mutation_p.R63H|CD80_uc003ecr.1_Missense_Mutation_p.R63H	NM_005191	NP_005182	P33681	CD80_HUMAN	Homo sapiens CD80 molecule (CD80), mRNA.	63	Ig-like V-type.				T cell costimulation|interspecies interaction between organisms|intracellular signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of transcription, DNA-dependent	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	CCAGTAGATGCGAGTTTGTGC	0.468000														186			8		0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28456246	28456246	+	Missense_Mutation	SNP	T	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr15:28456246T>A	uc001zbj.3	-	43	7077	c.6971A>T	c.(6970-6972)tAc>tTc	p.Y2324F		NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	2324					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTTCAGGATGTATAGCTTCAA	0.582000														258			7		0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2306576	2306576	+	Silent	SNP	T	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr20:2306576T>C	uc002wfx.4	+	7	1162	c.1065T>C	c.(1063-1065)gcT>gcC	p.A355A		NM_003245	NP_003236	Q08188	TGM3_HUMAN	Homo sapiens transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM3), mRNA.	355					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	GDP binding|GTP binding|GTPase activity|acyltransferase activity|calcium ion binding|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	TGTTGGATGCTACCCCGCAGG	0.522000														104			14		0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34021909	34021909	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr20:34021909A>G	uc010gfc.1	-	1	1545	c.1304T>C	c.(1303-1305)tTc>tCc	p.F435S	GDF5OS_uc002xcj.3_Missense_Mutation_p.E107G|GDF5_uc002xck.1_Missense_Mutation_p.F435S	NM_000557	NP_000548	P43026	GDF5_HUMAN	Homo sapiens growth differentiation factor 5 (GDF5), mRNA.	435					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCGCAATGGGAACTCGCACAG	0.602000														141			4		0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9900608	9900608	+	Silent	SNP	A	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chrX:9900608A>C	uc004csu.1	+	5	3375	c.3285A>C	c.(3283-3285)ccA>ccC	p.P1095P	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	Homo sapiens shroom family member 2 (SHROOM2), mRNA.	1095					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				GGCCCTTCCCAACGCCATCCC	0.697000														33			4		0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17150316	17150316	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr21:17150316G>A	uc011aby.1	+	3	579	c.362G>A	c.(361-363)gGa>gAa	p.G121E	USP25_uc002yjz.1_Missense_Mutation_p.G121E|USP25_uc010gla.1_Missense_Mutation_p.G121E|USP25_uc002yjy.1_Missense_Mutation_p.G121E	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	Homo sapiens ubiquitin specific peptidase 25 (USP25), mRNA.	121					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGGGAGACTGGAATAACTGAT	0.343000														70			7		0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52919685	52919685	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr19:52919685G>T	uc002pzh.3	+	6	2006	c.1580G>T	c.(1579-1581)gGc>gTc	p.G527V	ZNF528_uc002pzi.3_Missense_Mutation_p.G294V	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	Homo sapiens zinc finger protein 528 (ZNF528), mRNA.	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AATCAATGTGGCAAGGTCTTT	0.393000														85			6		2.74318e-10	2.93912e-10	1	1	0
CLCNKA	1187	broad.mit.edu	37	1	16383402	16383402	+	Silent	SNP	C	T	T	rs6698427		TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr1:16383402C>T	uc001axx.4	+	19	2191	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	CLCNKA_uc021ogm.1_Silent_p.A516A|CLCNKA_uc001axy.4_Silent_p.A515A	NM_000085	NP_000076	P51800	CLCKA_HUMAN	Homo sapiens chloride channel Kb (CLCNKB), transcript variant 1, mRNA.	685					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	ATCCGCCAGCCCCAAAGTGAG	0.587000														105			5		0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148010987	148010987	+	Silent	SNP	T	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr1:148010987T>C	uc001eqq.3	-	13	1667	c.1635A>G	c.(1633-1635)tcA>tcG	p.S545S	NBPF14_uc001eqe.3_Silent_p.S192S|NBPF14_uc001eqf.3_Silent_p.S641S|NBPF14_uc001eqg.3_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc021ovz.1_Intron|NBPF14_uc021owa.1_Silent_p.S526S|NBPF14_uc021owb.1_Silent_p.S456S|NBPF14_uc021owc.1_Silent_p.S212S|NBPF14_uc021owe.1_Silent_p.S180S|NBPF14_uc010pad.1_Non-coding_Transcript|NBPF14_uc021owd.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 14 (NBPF14), mRNA.	545	NBPF 6.					cytoplasm		p.S545S(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					CTGAAGGAGTTGAATAACATC	0.478000														96			6		0	0	1	0	0
CD99	4267	broad.mit.edu	37	X	2658825	2658825	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chrX:2658825C>T	uc004cqm.3	+	9	712	c.538C>T	c.(538-540)Cgt>Tgt	p.R180C	CD99_uc010nda.3_Missense_Mutation_p.R164C|CD99_uc004cqn.3_Non-coding_Transcript	NM_002414	NP_002405	P14209	CD99_HUMAN	Homo sapiens CD99 molecule (CD99), transcript variant 1, mRNA.	180					cell adhesion	cytoplasm|integral to plasma membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11						CACAGTTCAGCGTACTCTTTT	0.507000														224			4		0	0	1	0	0
UCN3	114131	broad.mit.edu	37	10	5415962	5415962	+	Silent	SNP	C	T	T			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr10:5415962C>T	uc001ihx.1	+	1	503	c.279C>T	c.(277-279)acC>acT	p.T93T		NM_053049	NP_444277	Q969E3	UCN3_HUMAN	Homo sapiens urocortin 3 (stresscopin) (UCN3), mRNA.	93						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						CCAGAGGCACCCGGTACAGAT	0.627000														28			3		0	0	1	0	0
YTHDC1	91746	broad.mit.edu	37	4	69195975	69195975	+	Missense_Mutation	SNP	T	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr4:69195975T>A	uc003hdx.3	-	7	1529	c.1176A>T	c.(1174-1176)agA>agT	p.R392S	YTHDC1_uc003hdy.3_Missense_Mutation_p.R374S	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	Homo sapiens YTH domain containing 1 (YTHDC1), transcript variant 1, mRNA.	392	YTH.									NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						TCCTTGCAGATCTAAATGCAA	0.294000														121			28		0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1270045	1270045	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr11:1270045A>C	uc001lta.3	+	30	11994	c.11935A>C	c.(11935-11937)Acc>Ccc	p.T3979P		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	3979	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		gctgaccaccaccgccaccac	0.642000														116			8		0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr17:7578212G>A	uc002gim.2	-	5	831	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.3_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.2_Nonsense_Mutation_p.R174*|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(467)|p.R213L(35)|p.R213Q(27)|p.R81*(21)|p.R120*(21)|p.R213fs*34(13)|p.F212fs*3(11)|p.0?(8)|p.R213G(8)|p.R213P(5)|p.?(5)|p.R213R(5)|p.R213fs*35(4)|p.F212L(3)|p.D208_V216delDRNTFRHSV(2)|p.D207_R213delDDRNTFR(2)|p.T211_S215delTFRHS(2)|p.F212I(2)|p.F212S(2)|p.R209_R213delRNTFR(2)|p.R213fs*2(2)|p.R213_S215>X(2)|p.D207_V216del10(2)|p.R213fs*32(2)|p.R213W(2)|p.K164_P219del(1)|p.R120G(1)|p.T211_F212insX(1)|p.F212fs*4(1)|p.R213*33(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R213>L(1)|p.R120fs*35(1)|p.R81G(1)|p.F212Y(1)|p.T211fs*28(1)|p.R209fs*6(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)				48			5		0	0	1	0	0
CLECL1	160365	broad.mit.edu	37	12	9885606	9885606	+	Silent	SNP	G	A	A			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr12:9885606G>A	uc001qwi.3	-	0	290	c.255C>T	c.(253-255)taC>taT	p.Y85Y	CLECL1_uc001qwj.3_Silent_p.Y85Y	NM_001253750	NP_001240679	Q8IZS7	CLCL1_HUMAN	Homo sapiens C-type lectin-like 1 (CLECL1), transcript variant 3, mRNA.	85						integral to membrane|plasma membrane	sugar binding			breast(1)|kidney(1)|large_intestine(4)|lung(3)	9						TGATGTCAGCGTAGACTACAT	0.428000														58			12		0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840231	128840231	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8416-01A-11D-2310-10	TCGA-KO-8416-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d29543e-8601-4fd0-8e76-3df3de465cab	539a0194-ea33-4213-b815-b8dbbc07a276	g.chr11:128840231T>C	uc009zcp.3	-	21	4835	c.4835A>G	c.(4834-4836)tAc>tGc	p.Y1612C	ARHGAP32_uc009zcq.2_3'UTR|ARHGAP32_uc009zco.3_Missense_Mutation_p.Y571C|ARHGAP32_uc001qez.3_Missense_Mutation_p.Y1263C	NM_001142685	NP_055530	A7KAX9	RHG32_HUMAN	Homo sapiens Rho GTPase activating protein 32 (ARHGAP32), transcript variant 1, mRNA.	1612	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	Golgi membrane|cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TCTTGGGCAGTAGGCTGGCTC	0.532000														130			11		0	0	1	0	0
