Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPS6KA6	27330	broad.mit.edu	37	X	83361951	83361951	+	Silent	SNP	A	G	G			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chrX:83361951A>G	uc004eej.2	-	13	1245	c.1209T>C	c.(1207-1209)ccT>ccC	p.P403P	RPS6KA6_uc011mqt.2_Silent_p.P403P|RPS6KA6_uc011mqu.2_Silent_p.P300P	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 (RPS6KA6), mRNA.	403					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						CACTTGTGATAGGAGTGATTT	0.353000														24			88		0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042327	75042327	+	Missense_Mutation	SNP	C	T	T	rs138652540		TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr15:75042327C>T	uc002ayr.1	+	1	312	c.248C>T	c.(247-249)aCg>aTg	p.T83M		NM_000761	NP_000752	P05177	CP1A2_HUMAN	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2), mRNA.	83			T -> M (in allele CYP1A2*9).		alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding	p.T83T(1)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	ATTGGCTCCACGCCCGTGCTG	0.667000														41			6		0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595572	129595572	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr9:129595572G>A	uc022bnm.1	+	0	784	c.784G>A	c.(784-786)Gcg>Acg	p.A262T	ZBTB43_uc004bql.3_Missense_Mutation_p.A262T|ZBTB43_uc010mxf.3_Missense_Mutation_p.A262T	NM_014007	NP_054726	O43298	ZBT43_HUMAN	Homo sapiens zinc finger and BTB domain containing 43 (ZBTB43), transcript variant 1, mRNA.	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						GGATGTGCACGCGACCTACGA	0.607000														51			7		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117043	117043	+	RNA	SNP	C	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chrGL000205.1:117043C>T	uc002kgk.4	+	0		c.421C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GACAACCCATCGTGTGAACTA	0.453000														16			4		0	0	1	0	0
BC132948	0	broad.mit.edu	37	2	240500560	240500560	+	Silent	SNP	T	C	C	rs115567488	by1000genomes	TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr2:240500560T>C	uc002vym.1	+	0	566	c.441T>C	c.(439-441)atT>atC	p.I147I						SubName: Full=Uncharacterized protein; SubName: Full=cDNA FLJ45964 fis, clone PLACE7014396;																		tgggttcaattaagaaggtta	0.478000														21			3		0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123663688	123663688	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr4:123663688G>A	uc021xrm.1	+	2	1022	c.641G>A	c.(640-642)cGa>cAa	p.R214Q	BBS12_uc003ieu.3_Missense_Mutation_p.R214Q|BBS12_uc021xrn.1_Missense_Mutation_p.R214Q	NM_001178007	NP_689831	Q6ZW61	BBS12_HUMAN	Homo sapiens Bardet-Biedl syndrome 12 (BBS12), transcript variant 1, mRNA.	214					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						AACACATCACGAACTCTGAAA	0.398000									Bardet-Biedl syndrome					68			25		0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157078493	157078493	+	Silent	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr5:157078493G>A	uc003lxb.1	-	0	936	c.594C>T	c.(592-594)ggC>ggT	p.G198G	SOX30_uc003lxc.1_Silent_p.G198G|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	Homo sapiens SRY (sex determining region Y)-box 30 (SOX30), transcript variant 1, mRNA.	198					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGCCTGCCCCGCCTTGCATCG	0.657000														72			5		0	0	1	0	0
STK25	10494	broad.mit.edu	37	2	242437048	242437048	+	Missense_Mutation	SNP	G	A	A	rs140408761		TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr2:242437048G>A	uc002wbm.3	-	8	1358	c.1087C>T	c.(1087-1089)Cgg>Tgg	p.R363W	STK25_uc002wbl.3_3'UTR|STK25_uc002wbn.3_Missense_Mutation_p.R363W|STK25_uc002wbo.3_Missense_Mutation_p.R286W|STK25_uc010zos.2_Missense_Mutation_p.R269W|STK25_uc010zot.2_Missense_Mutation_p.R289W|STK25_uc002wbp.3_Missense_Mutation_p.R363W|STK25_uc010fzo.3_Missense_Mutation_p.R286W|STK25_uc010zou.2_Missense_Mutation_p.R269W|STK25_uc010zov.2_Missense_Mutation_p.R269W	NM_006374	NP_006365	O00506	STK25_HUMAN	Homo sapiens serine/threonine kinase 25 (STK25), mRNA.	363					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		AAGACGGGCCGGACCAGCGTG	0.657000														79			4		0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94827677	94827677	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr7:94827677G>A	uc003unp.3	+	5	2053	c.1771G>A	c.(1771-1773)Gaa>Aaa	p.E591K	PPP1R9A_uc010lfj.3_Missense_Mutation_p.E591K|PPP1R9A_uc011kif.2_Missense_Mutation_p.E591K|PPP1R9A_uc003unq.3_Missense_Mutation_p.E591K|PPP1R9A_uc011kig.2_Missense_Mutation_p.E591K	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 9A (PPP1R9A), transcript variant 4, mRNA.	591	PDZ.					cell junction|synapse|synaptosome	actin binding	p.E591*(3)|p.R590W(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TATTGGGCGGGAAAAACCAGG	0.448000										HNSCC(28;0.073)				68			15		0	0	1	0	0
PDZD11	51248	broad.mit.edu	37	X	69506937	69506937	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chrX:69506937G>T	uc004dye.1	-	6	759	c.514C>A	c.(514-516)Cac>Aac	p.H172N	KIF4A_uc004dyg.3_5'Flank|KIF4A_uc010nkw.3_5'Flank|PDZD11_uc004dyd.1_Missense_Mutation_p.H140N|KIF4A_uc004dyf.2_5'Flank	NM_016484	NP_057568	Q5EBL8	PDZ11_HUMAN	Homo sapiens PDZ domain containing 11 (PDZD11), mRNA.	140						basolateral plasma membrane|cytosol|extracellular region	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(3)|lung(3)	9						ACTTTCTAGTGCACAGTCCTC	0.483000														108			6		5.18039e-06	5.71629e-06	1	1	0
LIPC	3990	broad.mit.edu	37	15	58837951	58837951	+	Silent	SNP	C	T	T	rs149322349		TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr15:58837951C>T	uc010bga.2	+	6	1193	c.585C>T	c.(583-585)gcC>gcT	p.A195A	LIPC_uc010bfz.1_Silent_p.A195A|LIPC_uc002afa.2_Silent_p.A195A|LIPC_uc010bgb.1_Silent_p.A93A|LIPC_uc010ugy.2_Silent_p.A134A	NM_000236	NP_000227	P11150	LIPC_HUMAN	Homo sapiens lipase, hepatic (LIPC), mRNA.	195					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity	p.A195A(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GGCTGGATGCCGCGGGACCTT	0.493000														33			6		0	0	1	0	0
ZNF469	84627	broad.mit.edu	37	16	88497528	88497528	+	Missense_Mutation	SNP	C	T	T	rs115183769	by1000genomes	TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr16:88497528C>T	uc002fku.2	+	1	3566	c.3566C>T	c.(3565-3567)cCg>cTg	p.P1189L		NM_001127464	NP_001120936	Q96JG9	ZN469_HUMAN	Homo sapiens zinc finger protein 469 (ZNF469), mRNA.	1189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(6)|kidney(3)|large_intestine(1)|skin(6)	20						GAAACCCGCCCGTCGCTGGAC	0.642000														21			3		0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44982053	44982053	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr19:44982053G>T	uc002ozf.4	-	4	927	c.645C>A	c.(643-645)aaC>aaA	p.N215K	ZNF180_uc002ozh.4_5'UTR|ZNF180_uc002ozi.4_Missense_Mutation_p.N188K|ZNF180_uc002ozg.4_Missense_Mutation_p.N214K|ZNF180_uc010ejm.3_Missense_Mutation_p.N190K	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	Homo sapiens zinc finger protein 180 (ZNF180), mRNA.	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				TATGAAAATGGTTTCTTATGG	0.353000														42			4		0.00909568	0.00909568	1	1	0
DAAM1	23002	broad.mit.edu	37	14	59793702	59793702	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr14:59793702G>T	uc001xdz.1	+	11	1490	c.1365G>T	c.(1363-1365)atG>atT	p.M455I	DAAM1_uc001xea.1_Missense_Mutation_p.M455I|DAAM1_uc001xeb.1_Missense_Mutation_p.M455I	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	Homo sapiens dishevelled associated activator of morphogenesis 1 (DAAM1), mRNA.	455					actin cytoskeleton organization	cytoplasm|plasma membrane	Rho GTPase binding|actin binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CGGAAAAAATGAGAAAAGGTA	0.333000														39			4		0.000157383	0.00016246	1	1	0
ZNF658	26149	broad.mit.edu	37	9	40774999	40774999	+	Missense_Mutation	SNP	T	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr9:40774999T>A	uc004abs.2	-	4	428	c.276A>T	c.(274-276)gaA>gaT	p.E92D	ZNF658_uc010mmm.2_Missense_Mutation_p.E92D|ZNF658_uc010mmn.1_Missense_Mutation_p.E92D	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	Homo sapiens zinc finger protein 658 (ZNF658), mRNA.	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTTCTTGTTTTTCCCGGATCC	0.308000														25			14		0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35969403	35969403	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chrX:35969403G>A	uc004ddj.3	+	4	878	c.812G>A	c.(811-813)cGt>cAt	p.R271H	CXorf22_uc010ngv.3_Non-coding_Transcript	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	Homo sapiens chromosome X open reading frame 22 (CXorf22), mRNA.	271										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AAACATGCACGTGTATACAAT	0.413000														118			10		0	0	1	0	0
RHD	6007	broad.mit.edu	37	1	25655508	25655508	+	Missense_Mutation	SNP	A	G	G	rs112146441	by1000genomes	TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr1:25655508A>G	uc009vro.3	+	8	1421	c.1363A>G	c.(1363-1365)Agc>Ggc	p.S455G	C1orf63_uc021ojj.1_Intron|RHD_uc001bjz.3_3'UTR|RHD_uc001bkc.3_3'UTR|RHD_uc009vrm.3_3'UTR|RHD_uc001bka.3_Missense_Mutation_p.S425G|RHD_uc001bkb.3_3'UTR|RHD_uc009vrn.3_3'UTR|RHD_uc009vrp.3_3'UTR			Q02161	RHD_HUMAN	Homo sapiens Rh blood group, D antigen (RHD), transcript variant 1, mRNA.	0						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGCTCATGACAGCAAAGTCTC	0.428000														3			3		0	0	1	0	0
CLDN23	137075	broad.mit.edu	37	8	8560021	8560021	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr8:8560021A>C	uc003wsi.3	+	0	356	c.113A>C	c.(112-114)aAc>aCc	p.N38T		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	Homo sapiens claudin 23 (CLDN23), mRNA.	38					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)	2		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		GGCTTCCTGAACCAGCCAGTG	0.687000														7			3		0	0	1	0	0
MGC39584	441058	broad.mit.edu	37	GL000193.1	88363	88363	+	RNA	SNP	A	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chrGL000193.1:88363A>T	uc003izx.3	-	0		c.13T>A			MGC39584_uc003izy.3_5'Flank					Homo sapiens uncharacterized LOC441058 (MGC39584), non-coding RNA.																		cagagcctcgatacccaagca	0.607000														3			2		0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223027	35223027	+	Silent	SNP	C	T	T	rs61750010	byFrequency	TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr1:35223027C>T	uc001bxu.3	+	1	196	c.96C>T	c.(94-96)cgC>cgT	p.R32R	GJB5_uc021okz.1_Silent_p.R32R|GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	Homo sapiens gap junction protein, beta 5, 31.1kDa (GJB5), mRNA.	32					cell communication|epidermis development	connexon complex|integral to membrane		p.R32H(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				TCATCTTCCGCGTGCTGGTGT	0.572000														146			5		0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265325	75265325	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr14:75265325C>T	uc001xqj.4	+	4	3449	c.3325C>T	c.(3325-3327)Cga>Tga	p.R1109*	YLPM1_uc001xql.4_Non-coding_Transcript	NM_019589	NP_062535	P49750	YLPM1_HUMAN	Homo sapiens YLP motif containing 1 (YLPM1), mRNA.	914	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGCTGGCAGCCGAGAAAGGGG	0.627000														45			4		0	0	1	0	0
PSMD12	5718	broad.mit.edu	37	17	65340732	65340732	+	Missense_Mutation	SNP	A	G	G	rs2230680	byFrequency	TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr17:65340732A>G	uc002jfy.3	-	8	1159	c.1073T>C	c.(1072-1074)gTt>gCt	p.V358A	PSMD12_uc002jga.3_Missense_Mutation_p.V338A|PSMD12_uc002jfz.3_Missense_Mutation_p.V299A	NM_002816	NP_002807	O00232	PSD12_HUMAN	Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (PSMD12), transcript variant 1, mRNA.	358	PCI.		V -> A (in dbSNP:rs2230680).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	proteasome regulatory particle	protein binding			breast(1)|large_intestine(4)|lung(6)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					ATGTTCAACAACTCTGTTCTT	0.328000														64			4		0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8994179	8994179	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr19:8994179C>T	uc002mkp.3	-	64	41710	c.41506G>A	c.(41506-41508)Ggc>Agc	p.G13836S	MUC16_uc010dwi.3_Non-coding_Transcript|MUC16_uc010dwj.3_Missense_Mutation_p.G653S|MUC16_uc021uog.1_Non-coding_Transcript	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	13839	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TACAGAGGGCCAACACTGGTG	0.522000														123			34		0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45396746	45396746	+	Missense_Mutation	SNP	C	G	G			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr5:45396746C>G	uc003jok.3	-	3	1103	c.1078G>C	c.(1078-1080)Ggg>Cgg	p.G360R		NM_021072	NP_066550	O60741	HCN1_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1), mRNA.	360						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GCTCCATACCCAATGCACAGC	0.483000														142			129		0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127915854	127915854	+	Silent	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr9:127915854G>A	uc010mwv.3	-	6	959	c.738C>T	c.(736-738)ccC>ccT	p.P246P	PPP6C_uc004bpg.4_Silent_p.P209P|PPP6C_uc010mww.3_Silent_p.P187P|PPP6C_uc011lzr.2_Silent_p.P62P	NM_001123355	NP_001116827	O00743	PPP6_HUMAN	Homo sapiens protein phosphatase 6, catalytic subunit (PPP6C), transcript variant 1, mRNA.	209					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						CTGCTCCTCGGGGACTGATAG	0.438000														40			13		0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12898343	12898343	+	Silent	SNP	C	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr17:12898343C>T	uc002gnz.4	-	19	1962	c.1845G>A	c.(1843-1845)gaG>gaA	p.E615E	ELAC2_uc002gnu.4_Silent_p.E12E|ELAC2_uc002gnv.4_Silent_p.E243E|ELAC2_uc002gnx.4_Silent_p.E375E|ELAC2_uc010vvo.2_Silent_p.E413E|ELAC2_uc010vvp.2_Silent_p.E596E|ELAC2_uc010vvq.2_Silent_p.E614E|ELAC2_uc010vvr.2_Silent_p.E575E	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	Homo sapiens elaC homolog 2 (E. coli) (ELAC2), transcript variant 1, mRNA.	615					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						GACTGGAGATCTCAGCCCCTT	0.453000														102			4		0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214171103	214171103	+	Silent	SNP	C	T	T			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr1:214171103C>T	uc001hkh.3	+	1	1497	c.1225C>T	c.(1225-1227)Ctg>Ttg	p.L409L	PROX1_uc001hkg.1_Silent_p.L409L	NM_002763	NP_002754	Q92786	PROX1_HUMAN	Homo sapiens prospero homeobox 1 (PROX1), mRNA.	409					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of S phase of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CAACCAGCGCCTGCAGTGCTT	0.582000														57			8		0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772576	4772576	+	Missense_Mutation	SNP	G	C	C			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr1:4772576G>C	uc001alm.1	+	1	1027	c.646G>C	c.(646-648)Gtg>Ctg	p.V216L	AJAP1_uc001aln.3_Missense_Mutation_p.V216L	NM_001042478	NP_061324	Q9UKB5	AJAP1_HUMAN	Homo sapiens adherens junctions associated protein 1 (AJAP1), transcript variant 2, mRNA.	216	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GAAGACAACTGTGGccgccac	0.647000														3			16		0	0	1	0	0
NUTF2	10204	broad.mit.edu	37	16	67899046	67899046	+	Missense_Mutation	SNP	C	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr16:67899046C>A	uc002eup.3	+	1	112	c.13C>A	c.(13-15)Cca>Aca	p.P5T	NUTF2_uc010vkf.1_Missense_Mutation_p.P5T	NM_005796	NP_005787	P61970	NTF2_HUMAN	Homo sapiens nuclear transport factor 2 (NUTF2), mRNA.	5					protein transport	cytosol|nuclear pore	protein binding|transporter activity	p.P5T(2)		kidney(1)|lung(2)|upper_aerodigestive_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		GGGAGACAAGCCAATTTGGGA	0.488000														57			7		2.17888e-05	2.32414e-05	1	1	0
UGT1A1	54658	broad.mit.edu	37	2	234581245	234581245	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr2:234581245G>A	uc002vus.3	+	0	702	c.665G>A	c.(664-666)cGt>cAt	p.R222H	UGT1A1_uc010zmv.1_Intron|UGT1A1_uc002vup.3_Intron|UGT1A1_uc002vuq.3_Intron|UGT1A1_uc002vur.3_Intron|UGT1A1_uc010zmw.1_Missense_Mutation_p.R222H	NM_021027	NP_066307	P22309	UD11_HUMAN	Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A9 (UGT1A9), mRNA.	225					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding	p.R222H(2)		breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TTATGCCACCGTTTTTTCAAA	0.428000														72			5		0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178580530	178580530	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr5:178580530G>A	uc003mjw.3	-	8	1579	c.1477C>T	c.(1477-1479)Cgc>Tgc	p.R493C	ADAMTS2_uc011dgm.2_Missense_Mutation_p.R493C	NM_014244	NP_055059	O95450	ATS2_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2), transcript variant 1, mRNA.	493	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AAGTCAAAGCGGCATTGCTCG	0.662000														17			21		0	0	1	0	0
FHL3	2275	broad.mit.edu	37	1	38463083	38463083	+	Silent	SNP	C	A	A			TCGA-KO-8417-01A-11D-2310-10	TCGA-KO-8417-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7af04b-e171-47c4-8be5-5db33f20148e	32e33f58-0399-49bb-bc8c-1eeb122d4df4	g.chr1:38463083C>A	uc001cck.3	-	5	1016	c.837G>T	c.(835-837)ggG>ggT	p.G279G	FHL3_uc001ccm.3_Silent_p.G171G	NM_004468	NP_004459	Q13643	FHL3_HUMAN	Homo sapiens four and a half LIM domains 3 (FHL3), transcript variant 1, mRNA.	279					muscle organ development		zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGGCTTAGGGCCCTGCCTGGC	0.642000														43			6		5.9392e-07	6.78766e-07	1	1	0
