Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ZMYM6	9204	broad.mit.edu	37	1	35484994	35484994	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:35484994G>A	uc001byh.2	-	4	616	c.388C>T	c.(388-390)CTG>TTG	p.L130L	ZMYM6_uc001byf.1_Silent_p.L130L|ZMYM6_uc010oht.1_Silent_p.L33L|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Silent_p.L130L|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Silent_p.L130L|ZMYM6_uc001byi.2_Silent_p.L130L|ZMYM6_uc001byk.2_Silent_p.L130L	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	130	MYM-type 1.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGAGGTGGCAGGCAGGCAGGT	0.403000													14	42					0	0	0	0
INADL	10207	broad.mit.edu	37	1	62263043	62263043	+	Missense_Mutation	SNP	C	G	G	rs145732252		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:62263043C>G	uc001dab.2	+	11	1459	c.1345C>G	c.(1345-1347)CTA>GTA	p.L449V	INADL_uc009waf.1_Missense_Mutation_p.L449V|INADL_uc001daa.2_Missense_Mutation_p.L449V|INADL_uc001dad.3_Missense_Mutation_p.L146V	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	449	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ACACCTAACCCTAGTTCGAAG	0.443000													27	96					0	0	0	0
SCARNA2	677766	broad.mit.edu	37	1	109642857	109642857	+	RNA	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:109642857C>T	uc001dwo.1	+	1		c.43C>T				NR_003023				Homo sapiens cDNA clone IMAGE:6602628, partial cds.												0						GTGTTGTGTGCGGAGCTGTGG	0.662000													5	18					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	G	G	rs9424867		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													4	80					0	0	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155924729	155924729	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:155924729C>G	uc001fmt.2	-	14	1865	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	ARHGEF2_uc001fmr.2_Missense_Mutation_p.E555Q|ARHGEF2_uc001fms.2_Missense_Mutation_p.E582Q|ARHGEF2_uc001fmu.2_Missense_Mutation_p.E627Q	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	583					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCCTCTGTCTCAATCAGGGGG	0.368000													14	71					0	0	0	0
KIF14	9928	broad.mit.edu	37	1	200550381	200550381	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:200550381G>A	uc010ppk.1	-	20	3722	c.3283C>T	c.(3283-3285)CAG>TAG	p.Q1095*	KIF14_uc010ppj.1_Nonsense_Mutation_p.Q604*	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1095	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTGGCTTCCTGAATCATCATT	0.338000													9	68					0	0	0	0
IKBKE	9641	broad.mit.edu	37	1	206649530	206649530	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:206649530G>A	uc001hdz.1	+	6	733	c.365G>A	c.(364-366)GGC>GAC	p.G122D	IKBKE_uc009xbu.1_Missense_Mutation_p.G122D|IKBKE_uc009xbv.1_Missense_Mutation_p.G122D|IKBKE_uc001hea.1_Missense_Mutation_p.G37D	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	122	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCAGTGGCCGGCATGAACCAC	0.617000													3	39					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235940477	235940477	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:235940477G>A	uc001hxj.2	-	17	5521	c.5346C>T	c.(5344-5346)AGC>AGT	p.S1782S	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1782					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTAATAAGATGCTCTGAACTT	0.378000									Chediak-Higashi_syndrome				21	84					0	0	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17126756	17126756	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:17126756C>T	uc001mmq.3	-	22	3707	c.3641G>A	c.(3640-3642)TGG>TAG	p.W1214*	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Nonsense_Mutation_p.W834*|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1214	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTTCCTTAGCCACTCTGCAAG	0.398000													6	27					0	0	0	0
SERGEF	26297	broad.mit.edu	37	11	18028145	18028145	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:18028145C>A	uc001mnm.2	-	3	425	c.345G>T	c.(343-345)ATG>ATT	p.M115I	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Missense_Mutation_p.M115I|SERGEF_uc010rcz.1_Missense_Mutation_p.M1I|SERGEF_uc001mno.1_Missense_Mutation_p.M1I	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	115	RCC1 2.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						CACCTGTGAGCATAATCGTAA	0.468000													14	86					2.61681e-11	2.96572e-11	1	0
OR4X1	390113	broad.mit.edu	37	11	48285470	48285470	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:48285470A>G	uc010rht.1	+	1	58	c.58A>G	c.(58-60)AGT>GGT	p.S20G		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CCAGAATTGGAGTGAGCAGAG	0.453000													3	55					0	0	0	0
MS4A14	84689	broad.mit.edu	37	11	60183772	60183772	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:60183772A>T	uc001npj.2	+	5	1896	c.1331A>T	c.(1330-1332)AAC>ATC	p.N444I	MS4A14_uc001npi.2_Missense_Mutation_p.N332I|MS4A14_uc001npn.2_Missense_Mutation_p.N182I|MS4A14_uc001npk.2_Missense_Mutation_p.N427I|MS4A14_uc001npl.2_Missense_Mutation_p.N182I|MS4A14_uc001npm.2_Missense_Mutation_p.N182I	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	444	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CAACCAGAAAACACTGAACCT	0.373000													10	51					0	0	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67176566	67176566	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:67176566C>T	uc001ola.2	+	9	984	c.955C>T	c.(955-957)CCC>TCC	p.P319S	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Missense_Mutation_p.P254L|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	319						intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TCGAGCCATCCCCCCCGCGCA	0.692000													4	13					0	0	0	0
TRPC6	7225	broad.mit.edu	37	11	101323814	101323814	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:101323814C>G	uc001pgk.3	-	13	3093	c.2668G>C	c.(2668-2670)GAC>CAC	p.D890H	TRPC6_uc009ywy.2_Missense_Mutation_p.D774H	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	890	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTTGAGATGTCCTGCTTAATT	0.398000													8	61					0	0	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810420	106810420	+	Silent	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:106810420A>G	uc001pjg.1	-	4	1362	c.972T>C	c.(970-972)TGT>TGC	p.C324C	GUCY1A2_uc010rvo.1_Silent_p.C324C|GUCY1A2_uc009yxn.1_Silent_p.C324C	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	324					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GGAAGGCTCTACAGAAGGTGT	0.458000													9	25					0	0	0	0
OPCML	4978	broad.mit.edu	37	11	132527154	132527154	+	Silent	SNP	G	A	A	rs142071206	byFrequency	TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:132527154G>A	uc001qgs.2	-	2	278	c.228C>T	c.(226-228)TAC>TAT	p.Y76Y	OPCML_uc001qgu.2_Silent_p.Y69Y|OPCML_uc010sck.1_Silent_p.Y76Y|OPCML_uc001qgt.2_Silent_p.Y76Y|OPCML_uc010scl.1_Silent_p.Y35Y	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	76	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CATTCCCAGCGTAGAGGATGG	0.542000													12	71					0	0	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19413942	19413942	+	Silent	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:19413942C>G	uc001reb.2	+	7	683	c.597C>G	c.(595-597)CTC>CTG	p.L199L	PLEKHA5_uc010sie.1_Silent_p.L199L|PLEKHA5_uc001rea.2_Silent_p.L199L|PLEKHA5_uc009zin.2_Intron|PLEKHA5_uc010sif.1_Silent_p.L91L|PLEKHA5_uc010sig.1_Silent_p.L91L|PLEKHA5_uc010sih.1_Silent_p.L91L	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	199	PH.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCTTTGCCTCTTTTATTATA	0.303000													21	123					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944807	43944807	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:43944807C>T	uc010skx.1	-	2	358	c.358G>A	c.(358-360)GAC>AAC	p.D120N		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	120						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGCCCTGCGTCGCTCTCCCAG	0.662000													5	29					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102028349	102028349	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:102028349C>T	uc001tii.2	+	7	601	c.499C>T	c.(499-501)CCA>TCA	p.P167S	MYBPC1_uc001tif.1_Missense_Mutation_p.P180S|MYBPC1_uc001tig.2_Missense_Mutation_p.P192S|MYBPC1_uc010svq.1_Missense_Mutation_p.P154S|MYBPC1_uc001tih.2_Missense_Mutation_p.P192S|MYBPC1_uc001tij.2_Missense_Mutation_p.P167S|MYBPC1_uc010svr.1_Missense_Mutation_p.P167S|MYBPC1_uc010svs.1_Missense_Mutation_p.P167S|MYBPC1_uc010svt.1_Missense_Mutation_p.P155S|MYBPC1_uc010svu.1_Missense_Mutation_p.P167S|MYBPC1_uc001tik.2_Missense_Mutation_p.P141S	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	167					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TGGGACTACTCCAAACATTGA	0.358000													4	46					0	0	0	0
ALKBH2	121642	broad.mit.edu	37	12	109530419	109530419	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:109530419C>T	uc001tnx.2	-	2	566	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	ALKBH2_uc001tny.2_Missense_Mutation_p.R58Q|ALKBH2_uc010sxj.1_Missense_Mutation_p.R58Q|ALKBH2_uc009zvd.2_Missense_Mutation_p.R58Q|ALKBH2_uc010sxk.1_Missense_Mutation_p.R58Q	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	58					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CCGAATGTGCCGCCAGCTAGG	0.547000								Direct_reversal_of_damage					22	132					0	0	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927037	130927037	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:130927037G>A	uc001uil.2	-	8	973	c.809C>T	c.(808-810)CCA>CTA	p.P270L	RIMBP2_uc001uim.2_Missense_Mutation_p.P178L|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	270						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TATGTGGGTTGGGGAGTGGAG	0.577000													15	110					0	0	0	0
ZNF10	7556	broad.mit.edu	37	12	133732617	133732617	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:133732617A>T	uc009zzb.2	+	5	1232	c.785A>T	c.(784-786)GAG>GTG	p.E262V	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.E262V	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	262				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ATACATAGAGAGAAACCCTAT	0.398000													5	49					0	0	0	0
POMP	51371	broad.mit.edu	37	13	29252224	29252224	+	Silent	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:29252224A>G	uc001usf.2	+	6	492	c.411A>G	c.(409-411)AAA>AAG	p.K137K		NM_015932	NP_057016	Q9Y244	POMP_HUMAN	proteasome maturation protein	137					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex					0		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		TGGAATATAAACTTGGTTTAC	0.343000													11	40					0	0	0	0
TRPC4	7223	broad.mit.edu	37	13	38211559	38211559	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:38211559C>T	uc001uws.2	-	11	2650	c.2415G>A	c.(2413-2415)CCG>CCA	p.P805P	TRPC4_uc010abv.2_Silent_p.P385P|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Silent_p.P632P|TRPC4_uc010abx.2_Silent_p.P810P|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	805	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTGCTGATCTCGGATGAATCA	0.443000													10	79					0	0	0	0
RNF31	55072	broad.mit.edu	37	14	24629560	24629560	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:24629560C>T	uc001wmn.1	+	20	3358	c.3109C>T	c.(3109-3111)CGC>TGC	p.R1037C	RNF31_uc001wml.1_Missense_Mutation_p.R886C|RNF31_uc010alg.1_Missense_Mutation_p.R796C|RNF31_uc001wmo.1_Missense_Mutation_p.R504C|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_Missense_Mutation_p.R221C|IRF9_uc001wmq.2_5'Flank|IRF9_uc010alj.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	1037					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CCTGCACGTACGCCCCCAGCC	0.582000											OREG0022619	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	111					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47351384	47351384	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:47351384T>C	uc001wwj.3	-	11	2268	c.2072A>G	c.(2071-2073)AAT>AGT	p.N691S	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Missense_Mutation_p.N462S|MDGA2_uc010ani.2_Missense_Mutation_p.N251S	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	691					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AATATTCCCATTTATTTTAAT	0.373000													3	23					0	0	0	0
NID2	22795	broad.mit.edu	37	14	52481904	52481904	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:52481904C>T	uc001wzo.2	-	15	3352	c.3118G>A	c.(3118-3120)GTG>ATG	p.V1040M	NID2_uc010tqs.1_Missense_Mutation_p.V992M|NID2_uc010tqt.1_Missense_Mutation_p.V1040M|NID2_uc001wzp.2_Missense_Mutation_p.V1040M	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1040	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CACTGGGGCACGTACTGGTCA	0.632000													17	81					0	0	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75376271	75376271	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:75376271G>A	uc010tux.1	-	7	1773	c.1245C>T	c.(1243-1245)CCC>CCT	p.P415P	RPS6KL1_uc001xqx.1_Silent_p.P167P|RPS6KL1_uc001xqw.2_Silent_p.P384P|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	415	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GCAGGTTCCCGGGGTGGAGGT	0.672000													12	45					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94120290	94120290	+	Silent	SNP	G	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:94120290G>C	uc001ybv.1	+	36	5936	c.5853G>C	c.(5851-5853)GGG>GGC	p.G1951G	KIAA1409_uc001ybs.1_Silent_p.G1929G	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2106						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTCCAGATGGGACTTTTTTAC	0.483000													5	162					0	0	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414061	22414061	+	Silent	SNP	C	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:22414061C>A	uc001yuf.2	+	1	360	c.360C>A	c.(358-360)GTC>GTA	p.V120V		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						TTCTGATGGTCTTCAATAGTG	0.493000													11	104					1.58986e-06	1.7579e-06	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79054873	79054873	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:79054873C>T	uc002bej.3	-	23	4986	c.4775G>A	c.(4774-4776)CGC>CAC	p.R1592H		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1592	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CTTGACCAGGCGCCGCTGGAC	0.677000													3	12					0	0	0	0
PEX11A	8800	broad.mit.edu	37	15	90226612	90226612	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:90226612C>T	uc002boi.2	-	3	835	c.740G>A	c.(739-741)CGT>CAT	p.R247H	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	247	Cytoplasmic (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			AACACCCTAACGGGTCTTCAG	0.443000													62	207					0	0	0	0
MVP	9961	broad.mit.edu	37	16	29848052	29848052	+	Missense_Mutation	SNP	C	T	T	rs150165807		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:29848052C>T	uc002dui.2	+	7	766	c.682C>T	c.(682-684)CAC>TAC	p.H228Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010bzh.1_RNA|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.H228Y|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	228	MVP 5.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GACAGCCCTGCACCTCCGGGC	0.622000													4	46					0	0	0	0
SRCAP	10847	broad.mit.edu	37	16	30750152	30750152	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:30750152C>T	uc002dze.1	+	34	9176	c.8791C>T	c.(8791-8793)CTG>TTG	p.L2931L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.L2726L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2931	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CAATCCCCTCCTGTCACCTGT	0.572000													12	79					0	0	0	0
ACD	65057	broad.mit.edu	37	16	67693460	67693460	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67693460G>A	uc002etq.3	-	4	988	c.651C>T	c.(649-651)CCC>CCT	p.P217P	ACD_uc002etp.3_Silent_p.P214P|ACD_uc002etr.3_Silent_p.P214P|ACD_uc010vjt.1_Missense_Mutation_p.P237S|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	217					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCCGTAGCCGGGGCTGCTCCG	0.677000													4	48					0	0	0	0
NLRP1	22861	broad.mit.edu	37	17	5486116	5486116	+	Missense_Mutation	SNP	G	C	C	rs141118572		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:5486116G>C	uc002gci.2	-	2	877	c.322C>G	c.(322-324)CCC>GCC	p.P108A	NLRP1_uc002gcg.1_Missense_Mutation_p.P108A|NLRP1_uc002gck.2_Missense_Mutation_p.P108A|NLRP1_uc002gcj.2_Missense_Mutation_p.P108A|NLRP1_uc002gcl.2_Missense_Mutation_p.P108A|NLRP1_uc002gch.3_Missense_Mutation_p.P108A|NLRP1_uc010clh.2_Missense_Mutation_p.P108A	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	108					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GGTTGGCTGGGAGACCCCAGG	0.602000													9	37					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578177	7578177	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7578177C>T	uc002gim.2	-	6	866	c.672G>A	c.(670-672)GAG>GAA	p.E224E	TP53_uc002gig.1_Silent_p.E224E|TP53_uc002gih.2_Silent_p.E224E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Silent_p.E92E|TP53_uc010cng.1_Silent_p.E92E|TP53_uc002gii.1_Silent_p.E92E|TP53_uc010cnh.1_Silent_p.E224E|TP53_uc010cni.1_Silent_p.E224E|TP53_uc002gij.2_Silent_p.E224E|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Silent_p.E131E|TP53_uc002gio.2_Silent_p.E92E|TP53_uc010vug.1_Silent_p.E185E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	224	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E224D(11)|p.0?(7)|p.E224E(6)|p.E224K(5)|p.E224*(4)|p.?(3)|p.E224G(2)|p.E224fs*4(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.E224fs*23(1)|p.V225fs*24(1)|p.E224fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACCAGACCTCAGGCGGCT	0.522000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	24					0	0	0	0
CNTROB	116840	broad.mit.edu	37	17	7842957	7842957	+	Missense_Mutation	SNP	C	T	T	rs141146363		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7842957C>T	uc002gjq.2	+	9	1973	c.1054C>T	c.(1054-1056)CGG>TGG	p.R352W	CNTROB_uc002gjp.2_Missense_Mutation_p.R352W|CNTROB_uc002gjr.2_Missense_Mutation_p.R254W|CNTROB_uc010vum.1_Missense_Mutation_p.R64W	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	352	Potential.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GGAGACTCTTCGGGCTGCCCT	0.612000													18	62					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35591984	35591984	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:35591984C>T	uc002hnm.2	-	25	3232	c.3041G>A	c.(3040-3042)CGA>CAA	p.R1014Q	ACACA_uc002hnk.2_Missense_Mutation_p.R936Q|ACACA_uc002hnl.2_Missense_Mutation_p.R956Q|ACACA_uc002hnn.2_Missense_Mutation_p.R1014Q|ACACA_uc002hno.2_Missense_Mutation_p.R1051Q|ACACA_uc010cuz.2_Missense_Mutation_p.R1014Q	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1014					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTCTCTTCTCGGAGGGCGAA	0.393000													11	49					0	0	0	0
KRT38	8687	broad.mit.edu	37	17	39594347	39594347	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:39594347G>T	uc002hwq.1	-	6	1662	c.1239C>A	c.(1237-1239)TGC>TGA	p.C413*		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	413	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				ACACGTACTTGCAGTCCTCGC	0.527000													8	54					0.000157383	0.000168536	1	0
NAGS	162417	broad.mit.edu	37	17	42083545	42083545	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:42083545G>A	uc002ies.2	+	3	855	c.855G>A	c.(853-855)CTG>CTA	p.L285L	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Silent_p.L285L|NAGS_uc002iet.2_5'UTR	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	285					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CCAAGGCGCTGCGGCCCACCA	0.667000													11	38					0	0	0	0
METTL2A	339175	broad.mit.edu	37	17	60501347	60501347	+	Silent	SNP	G	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:60501347G>T	uc002izv.2	+	1	102	c.84G>T	c.(82-84)CCG>CCT	p.P28P	METTL2A_uc002izw.2_5'UTR	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	28							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			TGAGAGATCCGGCGCGCGTCT	0.647000											OREG0024635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	45					0.000157383	0.000168536	1	0
LAMA3	3909	broad.mit.edu	37	18	21330961	21330961	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:21330961C>T	uc002kuq.2	+	5	850	c.764C>T	c.(763-765)GCA>GTA	p.A255V	LAMA3_uc010dlv.1_Missense_Mutation_p.A255V|LAMA3_uc002kur.2_Missense_Mutation_p.A255V	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	255	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTACCAAGGCAACAAACATC	0.473000													33	85					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31319491	31319491	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:31319491C>G	uc010dmg.1	+	11	2178	c.2123C>G	c.(2122-2124)TCC>TGC	p.S708C	ASXL3_uc002kxq.2_Missense_Mutation_p.S415C	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	708	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCACCAGTATCCAACTTACCT	0.393000													37	204					0	0	0	0
WDR7	23335	broad.mit.edu	37	18	54591315	54591315	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:54591315C>T	uc002lgk.1	+	22	3900	c.3689C>T	c.(3688-3690)GCC>GTC	p.A1230V	WDR7_uc002lgl.1_Missense_Mutation_p.A1197V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1230										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GAACTTTGTGCCGATGCCGAG	0.438000													4	135					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9066782	9066782	+	Silent	SNP	C	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:9066782C>A	uc002mkp.2	-	3	20868	c.20664G>T	c.(20662-20664)GCG>GCT	p.A6888A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6890	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCACATTAGTCGCTGCTGTGC	0.483000													37	177					6.53348e-20	7.46683e-20	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769049	31769049	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:31769049G>A	uc002nsy.3	-	2	1715	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	550					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGGCGGCATGGATGCTGGGAT	0.552000													12	130					0	0	0	0
TMEM145	284339	broad.mit.edu	37	19	42818774	42818774	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:42818774G>A	uc002otk.1	+	4	335	c.283G>A	c.(283-285)GCC>ACC	p.A95T		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	95						integral to membrane					0		Prostate(69;0.00682)				GGACTGCCTGGCCAAGGAGTC	0.642000													14	131					0	0	0	0
C5AR1	728	broad.mit.edu	37	19	47823557	47823557	+	Missense_Mutation	SNP	C	T	T	rs141160351		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:47823557C>T	uc002pgj.1	+	2	572	c.523C>T	c.(523-525)CGG>TGG	p.R175W		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	175	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CTTCCTGTACCGGGTGGTCCG	0.632000													29	133					0	0	0	0
ZNF649	65251	broad.mit.edu	37	19	52394087	52394087	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:52394087C>A	uc002pxy.2	-	5	1570	c.1302G>T	c.(1300-1302)GAG>GAT	p.E434D	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_RNA	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	434	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCTCACACTCATCACAGC	0.438000													27	145					3.01185e-09	3.35747e-09	1	0
ZNF761	388561	broad.mit.edu	37	19	53958193	53958193	+	Silent	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:53958193T>C	uc010eqp.2	+	7	890	c.432T>C	c.(430-432)TTT>TTC	p.F144F	ZNF761_uc010ydy.1_Silent_p.F90F|ZNF761_uc002qbt.1_Silent_p.F90F	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GATCAAGCTTTCATTCGCATC	0.393000													17	108					0	0	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55378185	55378185	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:55378185A>G	uc002qhl.3	+	9	1430	c.1367A>G	c.(1366-1368)TAG>TGG	p.*456W	KIR3DL2_uc010esh.2_Nonstop_Mutation_p.*439W|KIR3DL2_uc002qho.3_Nonstop_Mutation_p.*456W			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	456					immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGGGTTTTCTAGGGAGACAAC	0.527000													3	180					0	0	0	0
ZNF471	57573	broad.mit.edu	37	19	57037304	57037304	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57037304G>C	uc002qnh.2	+	5	2001	c.1868G>C	c.(1867-1869)GGA>GCA	p.G623A		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	623					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGTCATACTGGAGAAGAACCT	0.403000													9	45					0	0	0	0
ZNF548	147694	broad.mit.edu	37	19	57911175	57911175	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57911175C>G	uc002qom.2	+	3	1770	c.1520C>G	c.(1519-1521)TCC>TGC	p.S507C	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.S510C	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTGTGTGCTCCATGAATGTG	0.358000													9	44					0	0	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121505	27121505	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:27121505C>T	uc002rhu.3	+	2	296	c.138C>T	c.(136-138)GGC>GGT	p.G46G	DPYSL5_uc002rhv.3_Silent_p.G46G	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	46					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCCCTGGCGGGGCCAAGG	0.592000													14	57					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420319	56420319	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:56420319C>T	uc002rzn.2	+	2	1486	c.984C>T	c.(982-984)CAC>CAT	p.H328H		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	328	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCCTGAACACGCCAGGCACA	0.662000													11	112					0	0	0	0
POLR1B	84172	broad.mit.edu	37	2	113331325	113331325	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:113331325C>T	uc002thw.2	+	14	3038	c.2458C>T	c.(2458-2460)CAG>TAG	p.Q820*	POLR1B_uc010fkn.2_Nonsense_Mutation_p.Q764*|POLR1B_uc002thx.2_Nonsense_Mutation_p.Q681*|POLR1B_uc010fko.2_Nonsense_Mutation_p.Q637*|POLR1B_uc010fkp.2_Nonsense_Mutation_p.Q259*|POLR1B_uc010yxn.1_Nonsense_Mutation_p.Q858*|POLR1B_uc002thy.2_Nonsense_Mutation_p.Q681*|POLR1B_uc010yxo.1_Nonsense_Mutation_p.Q597*	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	820					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						AGCAAAACTGCAGTACGGAGA	0.438000													19	105					0	0	0	0
CPO	130749	broad.mit.edu	37	2	207824389	207824389	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:207824389G>A	uc002vby.2	+	5	453	c.407G>A	c.(406-408)CGC>CAC	p.R136H		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	136					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		TCAAGTATACGCAAGCTCCTT	0.353000													4	46					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212495211	212495211	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:212495211G>A	uc002veg.1	-	17	2153	c.2055C>T	c.(2053-2055)GCC>GCT	p.A685A	ERBB4_uc002veh.1_Silent_p.A685A|ERBB4_uc010zji.1_Silent_p.A675A|ERBB4_uc010zjj.1_Silent_p.A675A|ERBB4_uc010fut.1_Silent_p.A685A	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	685	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATCTTCTCAAGGCTCTTTTCT	0.393000										TSP Lung(8;0.080)			14	80					0	0	0	0
TNS1	7145	broad.mit.edu	37	2	218713727	218713727	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:218713727C>T	uc002vgt.2	-	17	1536	c.1138G>A	c.(1138-1140)GGG>AGG	p.G380R	TNS1_uc002vgr.2_Missense_Mutation_p.G380R|TNS1_uc002vgs.2_Missense_Mutation_p.G380R|TNS1_uc010zjv.1_Missense_Mutation_p.G380R|TNS1_uc010fvj.1_Missense_Mutation_p.G448R|TNS1_uc010fvk.1_Missense_Mutation_p.G505R|TNS1_uc010fvi.1_Missense_Mutation_p.G67R	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	380						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TTAACAGCCCCGGTGCTGCCG	0.607000													41	163					0	0	0	0
C2orf83	56918	broad.mit.edu	37	2	228476326	228476326	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:228476326C>T	uc002vph.2	-	3	472	c.237G>A	c.(235-237)AGG>AGA	p.R79R	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	79						membrane	folic acid binding|reduced folate carrier activity				0						CGGTAAGTTTCCTCATCCCTG	0.468000													18	65					0	0	0	0
SP140L	93349	broad.mit.edu	37	2	231264899	231264899	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:231264899G>A	uc010fxm.1	+	15	1346	c.1255G>A	c.(1255-1257)GAC>AAC	p.D419N	SP140L_uc010fxo.1_Missense_Mutation_p.D191N	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	419	PHD-type; degenerate.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GTTCTGTTGCGACACTTGTTC	0.498000													21	79					0	0	0	0
KLHL30	377007	broad.mit.edu	37	2	239049729	239049729	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:239049729C>T	uc002vxr.1	+	1	313	c.280C>T	c.(280-282)CGC>TGC	p.R94C		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	112											0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CACGGCTGCGCGCCTGCACTT	0.667000													18	81					0	0	0	0
PREX1	57580	broad.mit.edu	37	20	47296246	47296246	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:47296246G>A	uc002xtw.1	-	12	1505	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	494	DEP 1.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CGTCGTAGCGGAAGCGATACA	0.612000													16	95					0	0	0	0
PTGIS	5740	broad.mit.edu	37	20	48130868	48130868	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:48130868G>A	uc002xut.2	-	7	974	c.920C>T	c.(919-921)GCT>GTT	p.A307V	PTGIS_uc010zyi.1_Missense_Mutation_p.A168V	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	307					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity	p.A307S(1)		skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GCGGACAGCAGCCAGGGCTTC	0.577000													8	57					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	11014952	11014952	+	RNA	SNP	A	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr21:11014952A>T	uc002yis.1	-	7		c.1494T>A						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACATTGTCTACATTGCAGAA	0.333000													3	25					0	0	0	0
PRDM15	63977	broad.mit.edu	37	21	43287419	43287419	+	Silent	SNP	C	T	T	rs137957423		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr21:43287419C>T	uc002yzq.1	-	5	720	c.609G>A	c.(607-609)GCG>GCA	p.A203A	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCCTCCGTTCGCAATCTTCC	0.532000													20	119					0	0	0	0
PLA2G3	50487	broad.mit.edu	37	22	31535944	31535944	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:31535944C>T	uc003aka.2	-	1	526	c.397G>A	c.(397-399)GCA>ACA	p.A133T		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	133					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						TGCCCTGCTGCTCGCTTCTTC	0.632000													6	77					0	0	0	0
MKL1	57591	broad.mit.edu	37	22	40825661	40825661	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:40825661C>T	uc003ayv.1	-	4	457	c.250G>A	c.(250-252)GTG>ATG	p.V84M	MKL1_uc003ayw.1_Missense_Mutation_p.V84M|MKL1_uc010gye.1_Missense_Mutation_p.V84M|MKL1_uc010gyf.1_Missense_Mutation_p.V84M	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	84	RPEL 2.|Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TTCTTCTCCACCAGCTCCATG	0.572000			T	RBM15	acute megakaryocytic leukemia								6	68					0	0	0	0
SMC1B	27127	broad.mit.edu	37	22	45782901	45782901	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:45782901C>T	uc003bgc.2	-	11	1809	c.1757G>A	c.(1756-1758)AGG>AAG	p.R586K	SMC1B_uc003bgd.2_Missense_Mutation_p.R586K|SMC1B_uc003bge.1_Missense_Mutation_p.R369K	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	586	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTTAAGCTCCCTTAGTCTTTC	0.328000													34	93					0	0	0	0
C3orf23	285343	broad.mit.edu	37	3	44399311	44399311	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:44399311G>C	uc010him.2	+	3	353	c.108G>C	c.(106-108)TTG>TTC	p.L36F	C3orf23_uc003cnd.3_Missense_Mutation_p.L36F|C3orf23_uc003cne.3_5'UTR|C3orf23_uc003cnb.3_Missense_Mutation_p.L36F|C3orf23_uc003cnc.3_Missense_Mutation_p.L36F	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	36						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TCAATGCCTTGAGGCCTTTCT	0.388000													6	24					0	0	0	0
TMEM115	11070	broad.mit.edu	37	3	50392907	50392907	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:50392907T>C	uc003dan.1	-	2	1368	c.923A>G	c.(922-924)GAT>GGT	p.D308G		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	308					negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCATCATCATCCATGCTGGG	0.607000													9	36					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89478308	89478308	+	Silent	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:89478308T>C	uc003dqy.2	+	12	2352	c.2127T>C	c.(2125-2127)AGT>AGC	p.S709S	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	709	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCTTGGATAGTTTCCTACGTG	0.323000										TSP Lung(6;0.00050)			12	34					0	0	0	0
EPHA6	285220	broad.mit.edu	37	3	96706230	96706230	+	Silent	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:96706230A>G	uc010how.1	+	3	550	c.507A>G	c.(505-507)GTA>GTG	p.V169V	EPHA6_uc003drp.1_Silent_p.V169V	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	74	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CATACCAGGTATGTAATGTAA	0.378000													16	127					0	0	0	0
EIF2A	83939	broad.mit.edu	37	3	150264529	150264529	+	5'Flank	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:150264529G>A	uc003eya.2	+						SERP1_uc003exy.2_5'Flank|SERP1_uc003exz.2_RNA|EIF2A_uc003eyb.2_5'Flank|EIF2A_uc003eyc.2_5'Flank|EIF2A_uc011bnv.1_5'Flank|EIF2A_uc011bnw.1_5'Flank	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A						regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GAGGAGACGTGTAGGGGCCGG	0.612000													23	57					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921549	178921549	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:178921549T>G	uc003fjk.2	+	5	1188	c.1031T>G	c.(1030-1032)GTG>GGG	p.V344G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	344					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.V344A(1)|p.V344G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GCAACCTACGTGAATGTAAAT	0.303000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	44					0	0	0	0
MCF2L2	23101	broad.mit.edu	37	3	183041051	183041051	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:183041051C>T	uc003fli.1	-	6	665	c.575G>A	c.(574-576)CGC>CAC	p.R192H	MCF2L2_uc003flj.1_Missense_Mutation_p.R192H|MCF2L2_uc003flp.1_Missense_Mutation_p.R227H	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	192	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CTGACCGTGGCGATATTCCAA	0.488000													23	79					0	0	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6058428	6058428	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:6058428T>C	uc003giu.3	-	12	1979	c.1703A>G	c.(1702-1704)GAA>GGA	p.E568G	JAKMIP1_uc010idb.1_Missense_Mutation_p.E568G|JAKMIP1_uc010idc.1_Missense_Mutation_p.E383G|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E403G|JAKMIP1_uc003giv.3_Missense_Mutation_p.E568G|JAKMIP1_uc010ide.2_Missense_Mutation_p.E568G	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	568	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACGCACCTTTTCCAGCAAGTC	0.542000													18	72					0	0	0	0
YTHDC1	91746	broad.mit.edu	37	4	69203343	69203343	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:69203343G>A	uc003hdx.2	-	3	759	c.406C>T	c.(406-408)CGG>TGG	p.R136W	YTHDC1_uc003hdy.2_Missense_Mutation_p.R136W	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	136										upper_aerodigestive_tract(1)|ovary(1)	2						TCCCTTTTCCGGACACAGGTT	0.403000													5	43					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72215743	72215743	+	Silent	SNP	A	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:72215743A>T	uc003hfy.2	+	5	621	c.504A>T	c.(502-504)GGA>GGT	p.G168G	SLC4A4_uc010iic.2_Silent_p.G168G|SLC4A4_uc010iib.2_Silent_p.G168G|SLC4A4_uc003hfz.2_Silent_p.G168G|SLC4A4_uc003hgc.3_Silent_p.G124G|SLC4A4_uc003hga.2_Silent_p.G46G|SLC4A4_uc003hgb.3_Silent_p.G124G	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	168	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGGAGAAAGGATCCATCATGC	0.453000													15	70					0	0	0	0
PRSS12	8492	broad.mit.edu	37	4	119219987	119219987	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:119219987T>C	uc003ica.1	-	9	1785	c.1738A>G	c.(1738-1740)ATC>GTC	p.I580V		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	580	SRCR 4.					membrane	scavenger receptor activity			skin(1)	1						TCTTGCTTGATACAGTCAGCC	0.448000													12	63					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126242740	126242740	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126242740A>G	uc003ifj.3	+	1	5174	c.5174A>G	c.(5173-5175)GAG>GGG	p.E1725G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1725	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAGAGAGCAGAGGTAATGATT	0.353000													8	28					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126412581	126412581	+	Silent	SNP	C	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126412581C>A	uc003ifj.3	+	17	14604	c.14604C>A	c.(14602-14604)CCC>CCA	p.P4868P	FAT4_uc011cgp.1_Silent_p.P3109P|FAT4_uc003ifi.1_Silent_p.P2345P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4868	Cytoplasmic (Potential).			P -> S (in Ref. 4; BAB15534).	homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAATGCCCAAATTATCTC	0.458000													17	46					3.52763e-06	3.86902e-06	1	0
GZMK	3003	broad.mit.edu	37	5	54320494	54320494	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:54320494A>T	uc003jpl.1	+	2	115	c.71A>T	c.(70-72)AAT>ATT	p.N24I		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	24					proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GTAGGTTTCAATATGGAAATT	0.383000													7	19					0	0	0	0
FSTL4	23105	broad.mit.edu	37	5	132652310	132652310	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:132652310C>T	uc003kyn.1	-	5	662	c.444G>A	c.(442-444)TTG>TTA	p.L148L		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	148						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGACATTCTTCAAGCGGGCGT	0.547000											OREG0016777	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	80					0	0	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731697	140731697	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:140731697A>C	uc003ljo.1	+	1	1870	c.1870A>C	c.(1870-1872)ACA>CCA	p.T624P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.T624P	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	624	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGGTGCGCACAGCGCGTGC	0.706000													9	57					0	0	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273547	26273547	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:26273547G>A	uc003nhk.2	+	1	344	c.344G>A	c.(343-345)GGC>GAC	p.G115D	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	115					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						GTGTCGGAGGGCACCAAGGCG	0.567000													15	55					0	0	0	0
MAPK14	1432	broad.mit.edu	37	6	36020563	36020563	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:36020563C>T	uc003olp.2	+	2	685	c.204C>T	c.(202-204)ACC>ACT	p.T68T	MAPK14_uc011dth.1_Silent_p.T68T|MAPK14_uc003olo.2_Silent_p.T68T|MAPK14_uc003olq.2_Silent_p.T68T|MAPK14_uc003olr.2_Silent_p.T68T|MAPK14_uc011dti.1_5'UTR	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	68	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						CGAAAAGAACCTACAGAGAAC	0.378000													8	36					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129687384	129687384	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:129687384G>A	uc003qbn.2	+	33	4843	c.4738G>A	c.(4738-4740)GGC>AGC	p.G1580S	LAMA2_uc003qbo.2_Missense_Mutation_p.G1580S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1580	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAGTGCACTGGCCTTCTTCT	0.468000													11	88					0	0	0	0
TAAR6	319100	broad.mit.edu	37	6	132891604	132891604	+	Silent	SNP	T	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:132891604T>C	uc011eck.1	+	1	144	c.144T>C	c.(142-144)TTT>TTC	p.F48F		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	48	Helical; Name=1; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TGGCTGTGTTTGGAAACCTCC	0.527000													18	110					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963951	88963951	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:88963951A>G	uc011khi.1	+	4	2193	c.1655A>G	c.(1654-1656)TAT>TGT	p.Y552C		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	552						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAGAGGAAATATAATTTGGAC	0.343000										HNSCC(36;0.09)			4	40					0	0	0	0
ZNF789	285989	broad.mit.edu	37	7	99074083	99074083	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:99074083T>G	uc003uqq.1	+	2	223	c.4T>G	c.(4-6)TTC>GTC	p.F2V	ZNF789_uc003uqp.2_Missense_Mutation_p.F2V|ZNF789_uc010lfw.1_5'UTR	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAAGCCATGTTCCCACCAGC	0.562000													7	52					0	0	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508732	106508732	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:106508732C>T	uc003vdv.3	+	2	811	c.726C>T	c.(724-726)GGC>GGT	p.G242G	PIK3CG_uc003vdu.2_Silent_p.G242G|PIK3CG_uc003vdw.2_Silent_p.G242G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	242					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACACCCCCGGCGCCATCCTGC	0.527000													18	98					0	0	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192500	132192500	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:132192500G>A	uc003vra.3	-	2	1182	c.953C>T	c.(952-954)GCG>GTG	p.A318V	PLXNA4_uc003vrc.2_Missense_Mutation_p.A318V|PLXNA4_uc003vrb.2_Missense_Mutation_p.A318V	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	318	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACGGCCCCCGCTTTGGACAG	0.582000													7	42					0	0	0	0
C7orf49	78996	broad.mit.edu	37	7	134852541	134852541	+	Silent	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:134852541A>G	uc003vsl.2	-	3	423	c.156T>C	c.(154-156)ACT>ACC	p.T52T	C7orf49_uc003vsh.2_Intron|C7orf49_uc003vsj.2_Silent_p.T23T|C7orf49_uc003vsk.2_RNA|C7orf49_uc003vsm.2_RNA|C7orf49_uc003vsn.2_Silent_p.T51T|C7orf49_uc003vso.2_5'UTR	NM_024033	NP_076938	Q9BWK5	MRI_HUMAN	modulator of retrovirus infection	52						cytoplasm				large_intestine(1)|ovary(1)	2						TGCAGTACACAGTCCTTGTCG	0.473000													3	86					0	0	0	0
USP17L2	377630	broad.mit.edu	37	8	11996173	11996173	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:11996173G>T	uc003wvc.1	-	1	97	c.97C>A	c.(97-99)CAG>AAG	p.Q33K	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	33					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GAAGTCCGCTGGATTTCAGCA	0.527000													17	82					1.33834e-09	1.50425e-09	1	0
BNIP3L	665	broad.mit.edu	37	8	26238106	26238106	+	5'Flank	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:26238106G>A	uc003xex.1	+						uc003xew.2_RNA|BNIP3L_uc010luh.1_5'Flank|BNIP3L_uc010lui.1_5'Flank	NM_004331	NP_004322	O60238	BNI3L_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein						apoptosis|defense response to virus|induction of apoptosis|interspecies interaction between organisms|mitochondrial protein catabolic process|negative regulation of survival gene product expression	endoplasmic reticulum|integral to membrane|mitochondrial outer membrane|nuclear envelope	lamin binding|protein heterodimerization activity|protein homodimerization activity				0		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0019)|Epithelial(17;1.59e-12)|all cancers(2;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(2;2.57e-08)|Colorectal(74;0.135)		TCAAGTGAACGGCTAAAAAGT	0.388000													4	37					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	69031723	69031723	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:69031723A>G	uc003xxv.1	+	28	3505	c.3478A>G	c.(3478-3480)AGT>GGT	p.S1160G		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1160					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAAGATACATAGTTGCCTTGA	0.358000													48	55					0	0	0	0
TSPYL5	85453	broad.mit.edu	37	8	98290036	98290036	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:98290036C>T	uc003yhy.2	-	1	141	c.37G>A	c.(37-39)GCC>ACC	p.A13T		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	13					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					CGGTTTTTGGCGCGGGAGGAC	0.692000													4	26					0	0	0	0
SYBU	55638	broad.mit.edu	37	8	110587403	110587403	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:110587403C>T	uc003ynj.3	-	7	1887	c.1724G>A	c.(1723-1725)AGA>AAA	p.R575K	SYBU_uc003yni.3_Missense_Mutation_p.R572K|SYBU_uc003ynk.3_Missense_Mutation_p.R456K|SYBU_uc010mco.2_Missense_Mutation_p.R574K|SYBU_uc003ynl.3_Missense_Mutation_p.R574K|SYBU_uc010mcp.2_Missense_Mutation_p.R575K|SYBU_uc010mcq.2_Missense_Mutation_p.R575K|SYBU_uc003yno.3_Missense_Mutation_p.R456K|SYBU_uc010mcr.2_Missense_Mutation_p.R575K|SYBU_uc003ynm.3_Missense_Mutation_p.R574K|SYBU_uc003ynn.3_Missense_Mutation_p.R574K|SYBU_uc010mcs.2_Missense_Mutation_p.R456K|SYBU_uc010mct.2_Missense_Mutation_p.R575K|SYBU_uc010mcu.2_Missense_Mutation_p.R574K|SYBU_uc003ynp.3_Missense_Mutation_p.R507K|SYBU_uc010mcv.2_Missense_Mutation_p.R575K|SYBU_uc003ynh.3_Missense_Mutation_p.R369K|SYBU_uc011lhw.1_Missense_Mutation_p.R445K	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	575						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						ATCCAGCTCTCTCATGAGGCG	0.552000													6	83					0	0	0	0
LRRC6	23639	broad.mit.edu	37	8	133622493	133622493	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:133622493G>A	uc003ytk.2	-	10	1133	c.1059C>T	c.(1057-1059)GTC>GTT	p.V353V	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	353	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTGCAGGAAGGACAAGCTGAA	0.418000													10	67					0	0	0	0
PTPRD	5789	broad.mit.edu	37	9	8499728	8499728	+	Silent	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:8499728A>G	uc003zkk.2	-	24	2952	c.2241T>C	c.(2239-2241)TAT>TAC	p.Y747Y	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.Y747Y|PTPRD_uc003zkm.2_Silent_p.Y734Y|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	747	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATGCACCTGATATCCTCTTA	0.498000										TSP Lung(15;0.13)			16	88					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113308490	113308490	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:113308490C>G	uc010mtz.2	-	3	1206	c.869G>C	c.(868-870)CGA>CCA	p.R290P	SVEP1_uc010mua.1_Missense_Mutation_p.R290P|SVEP1_uc004beu.2_Missense_Mutation_p.R290P|SVEP1_uc004bev.2_Missense_Mutation_p.E19Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	290					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GCTTCCCATTCGGTCACAGCA	0.443000													3	1					0	0	0	0
PTGS1	5742	broad.mit.edu	37	9	125154466	125154466	+	Splice_Site	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:125154466A>G	uc004bmg.1	+	11	1580	c.1445_splice	c.e11-2	p.G482_splice	PTGS1_uc011lys.1_Splice_Site_p.G420_splice|PTGS1_uc010mwb.1_Splice_Site_p.G336_splice|PTGS1_uc004bmf.1_Splice_Site_p.G445_splice|PTGS1_uc004bmh.1_Splice_Site_p.G373_splice|PTGS1_uc011lyt.1_Splice_Site_p.G373_splice	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1						cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATCTCCTTGTAGGAGAGAAGG	0.488000													10	24					0	0	0	0
USP20	10868	broad.mit.edu	37	9	132637882	132637882	+	Silent	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:132637882C>T	uc004bys.2	+	21	2473	c.2262C>T	c.(2260-2262)GTC>GTT	p.V754V	USP20_uc004byr.2_Silent_p.V754V|USP20_uc004byt.1_Silent_p.V754V	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	754	DUSP 1.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				ACCTGGTGGTCATCCTGCCCC	0.622000													26	61					0	0	0	0
LCNL1	401562	broad.mit.edu	37	9	139879239	139879239	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:139879239A>G	uc004ckh.1	+	3	865	c.271A>G	c.(271-273)AAA>GAA	p.K91E		NM_207510	NP_997393	Q6ZST4	LCNL1_HUMAN	lipocalin-like 1	91							binding				0						GGAGATGCGGAAAGGGGGCCT	0.662000													7	9					0	0	0	0
KLHL15	80311	broad.mit.edu	37	X	24024381	24024381	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:24024381C>T	uc004dba.3	-	3	686	c.430G>A	c.(430-432)GGC>AGC	p.G144S		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	144	BACK.									ovary(1)|breast(1)	2						ATGTTTACGCCGAAATCATCT	0.428000													13	18					0	0	0	0
MAGED1	9500	broad.mit.edu	37	X	51640125	51640125	+	Silent	SNP	G	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:51640125G>A	uc004dpm.2	+	4	1469	c.1374G>A	c.(1372-1374)CAG>CAA	p.Q458Q	MAGED1_uc004dpn.2_Silent_p.Q514Q|MAGED1_uc004dpo.2_Silent_p.Q458Q	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	458					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					GTGCCTCACAGAACCCAGGTG	0.577000										Multiple Myeloma(10;0.10)			4	19					0	0	0	0
MTMR8	55613	broad.mit.edu	37	X	63579362	63579362	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:63579362C>T	uc004dvs.2	-	2	138	c.70G>A	c.(70-72)GCT>ACT	p.A24T	MTMR8_uc011mou.1_Missense_Mutation_p.A24T|MTMR8_uc004dvt.1_Missense_Mutation_p.A24T	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	24						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						ATCCCATTAGCTGGTTTCTTA	0.408000													14	18					0	0	0	0
PIGK	10026	broad.mit.edu	37	1	77558060	77558061	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:77558060_77558061insA	uc001dhk.2	-	11	1231_1232	c.1186_1187insT	c.(1186-1188)TAGfs	p.*396fs	PIGK_uc010orj.1_Frame_Shift_Ins_p.*320fs|PIGK_uc009wbx.2_Frame_Shift_Ins_p.*302fs	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	396					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TCATCAAGTCTAAAAAATGAAC	0.327													---	---	---							
Unknown	0	broad.mit.edu	37	10	134957014	134957014	+	IGR	DEL	C	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr10:134957014delC								GPR123 (11836 upstream) : KNDC1 (16957 downstream)																							TTTTTTTTTTCTGTCTGTAGG	0.468													---	---	---							
FRG2B	441581	broad.mit.edu	37	10	135438960	135438960	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr10:135438960delC	uc010qvg.1	-	4	533	c.480delG	c.(478-480)AGGfs	p.R160fs		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	160						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGGCCCGAGACCTATGCCGCT	0.557													---	---	---							
FAM155A	728215	broad.mit.edu	37	13	108518337	108518338	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:108518337_108518338insC	uc001vql.2	-	1	1123_1124	c.607_608insG	c.(607-609)GACfs	p.D203fs		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	203						integral to membrane	binding			skin(1)	1						CTCCTGCCCGTCCCCCCCGGCC	0.609													---	---	---							
Unknown	0	broad.mit.edu	37	14	20085255	20085255	+	IGR	DEL	G	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:20085255delG								P704P (64983 upstream) : OR4Q3 (130332 downstream)																							AAACTAGGCTGTGACAACAAG	0.294													---	---	---							
Unknown	0	broad.mit.edu	37	14	95193580	95193580	+	IGR	DEL	A	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:95193580delA								SERPINA13 (80250 upstream) : GSC (40981 downstream)																							TCAGTTTCTTAAaaaaaaaaa	0.363													---	---	---							
ATP6V0D1	9114	broad.mit.edu	37	16	67472541	67472543	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67472541_67472543delAGA	uc002ete.1	-	8	1044_1046	c.944_946delTCT	c.(943-948)TTCTAT>TAT	p.F315del	ATP6V0D1_uc010vjo.1_In_Frame_Del_p.F356del|ATP6V0D1_uc010vjn.1_In_Frame_Del_p.F238del	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	315					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		ACGAAGGCATAGAAGACACCAAA	0.552													---	---	---							
Unknown	0	broad.mit.edu	37	19	22792787	22792788	+	IGR	INS	-	G	G	rs143937220	by1000genomes	TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:22792787_22792788insG								ZNF98 (187639 upstream) : ZNF492 (24338 downstream)																							TACCATCTTCTCCCAGGAGTCA	0.579													---	---	---							
C1QTNF6	114904	broad.mit.edu	37	22	37584356	37584357	+	5'Flank	INS	-	A	A			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:37584356_37584357insA	uc003aqw.1	-						C1QTNF6_uc003aqx.1_5'Flank|C1QTNF6_uc003aqy.1_5'Flank|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6							collagen					0						agggagagagggcggagggagg	0.455													---	---	---							
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	GGC	GGC	rs67907220		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:147560457_147560458insGGC	uc003ikv.2	+	1	413_414	c.165_166insGGC	c.(163-168)insGGC	p.68_69insG		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	68_69					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.386													---	---	---							
Unknown	0	broad.mit.edu	37	X	134749350	134749350	+	IGR	DEL	A	-	-			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:134749350delA								DDX26B (32891 upstream) : CT45A1 (97835 downstream)																							AGCACATGAGAAAAAAAATAA	0.368													---	---	---							
