Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11298657	11298657	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:11298657A>G	uc001asd.2	-	12	1925	c.1804T>C	c.(1804-1806)TTT>CTT	p.F602L		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	602					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGGCGAACAAATTGGGTCAGA	0.532000													8	5					0	0	0	0
SYTL1	84958	broad.mit.edu	37	1	27677312	27677312	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:27677312G>T	uc001bnw.1	+	11	1200	c.1033G>T	c.(1033-1035)GGC>TGC	p.G345C	SYTL1_uc001bnv.1_Missense_Mutation_p.G333C|SYTL1_uc009vsu.1_Intron|SYTL1_uc001bnx.2_3'UTR|SYTL1_uc009vsv.1_Missense_Mutation_p.G345C	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	345	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGAGCTTCAGGGCCGCGTGCT	0.642000													20	24					2.70639e-06	1.48852e-05	1	0
BEND5	79656	broad.mit.edu	37	1	49202034	49202034	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:49202034C>T	uc001crx.3	-	5	1029	c.985G>A	c.(985-987)GCA>ACA	p.A329T	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Missense_Mutation_p.A160T	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	329	BEN.									skin(1)	1						ATCATAACTGCCAAGTTCTTC	0.483000													30	144					0	0	0	0
MYSM1	114803	broad.mit.edu	37	1	59131251	59131251	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:59131251T>C	uc009wab.1	-	17	2107	c.2084A>G	c.(2083-2085)TAT>TGT	p.Y695C	MYSM1_uc009waa.1_Missense_Mutation_p.Y101C|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	695					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ATTTCGATTATAGGGACTAAC	0.333000													9	67					0	0	0	0
GBP7	388646	broad.mit.edu	37	1	89616146	89616146	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:89616146T>A	uc001dna.2	-	6	877	c.738A>T	c.(736-738)TTA>TTT	p.L246F	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	246						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		CAACATGGAGTAAGAGTTTTT	0.383000													22	49					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99772515	99772515	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:99772515T>C	uc001dse.2	+	7	2347	c.2241T>C	c.(2239-2241)ACT>ACC	p.T747T	LPPR4_uc010oue.1_Silent_p.T689T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	747							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCGAAAACACTAGAAATATCT	0.473000													23	55					0	0	0	0
SETDB1	9869	broad.mit.edu	37	1	150934615	150934615	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:150934615G>A	uc001evu.2	+	17	3329	c.3139G>A	c.(3139-3141)GAC>AAC	p.D1047N	SETDB1_uc001evv.2_Missense_Mutation_p.D1047N|SETDB1_uc009wmg.1_Missense_Mutation_p.D1047N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1047	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGACACTGACGACCGAAACAA	0.279000													73	177					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152187879	152187879	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:152187879T>C	uc001ezt.1	-	3	6302	c.6226A>G	c.(6226-6228)AGG>GGG	p.R2076G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2076	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGACTGCCTTGACCCAGAC	0.627000													4	274					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152286148	152286148	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:152286148G>C	uc001ezu.1	-	3	1250	c.1214C>G	c.(1213-1215)GCT>GGT	p.A405G	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	405	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGATGAAGCTTGCCCGCG	0.562000									Ichthyosis				140	335					0	0	0	0
DENND1B	163486	broad.mit.edu	37	1	197480968	197480968	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:197480968C>T	uc010ppe.1	-	21	1983	c.1645G>A	c.(1645-1647)GGA>AGA	p.G549R	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						AGAATCTCTCCTAGTAAGTCC	0.418000													5	105					0	0	0	0
PFKFB2	5208	broad.mit.edu	37	1	207236550	207236550	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:207236550T>C	uc001hfg.2	+	5	480	c.371T>C	c.(370-372)ATT>ACT	p.I124T	PFKFB2_uc010psc.1_Missense_Mutation_p.I26T|PFKFB2_uc001hfh.2_Missense_Mutation_p.I124T|PFKFB2_uc009xcc.2_Missense_Mutation_p.I82T|PFKFB2_uc010psd.1_5'Flank	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	124	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					AATGGTCAGATTGCGGTAAGC	0.532000													9	98					0	0	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212521732	212521732	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:212521732A>T	uc001hjb.2	+	7	1340	c.766A>T	c.(766-768)ATT>TTT	p.I256F	PPP2R5A_uc010ptd.1_Missense_Mutation_p.I197F	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	256					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		TCCCTCCAGTATTATCAATGG	0.368000													28	67					0	0	0	0
BPNT1	10380	broad.mit.edu	37	1	220253139	220253139	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:220253139G>C	uc001hma.2	-	2	222	c.50C>G	c.(49-51)TCT>TGT	p.S17C	BPNT1_uc010pug.1_Intron|BPNT1_uc010puh.1_Missense_Mutation_p.S17C|BPNT1_uc001hmb.3_Missense_Mutation_p.S17C	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	17					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		TTGAGCAATAGAATATGCGGA	0.413000													8	56					0	0	0	0
WDR64	128025	broad.mit.edu	37	1	241958516	241958516	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:241958516G>C	uc001hzf.1	+	15	1787	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	WDR64_uc001hzg.1_Missense_Mutation_p.R458T	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	992										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAGATTCGAAGATATCCCTTG	0.338000													28	117					0	0	0	0
OR2T12	127064	broad.mit.edu	37	1	248458107	248458107	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:248458107C>T	uc010pzj.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTGGGTCTCATATAGGTAA	0.483000													50	98					0	0	0	0
OR2T6	254879	broad.mit.edu	37	1	248551197	248551197	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:248551197C>A	uc001iei.1	+	1	288	c.288C>A	c.(286-288)GCC>GCA	p.A96A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTCATCGCCTGCACTGCTC	0.532000													30	75					3.65163e-15	2.10275e-14	1	0
NMT2	9397	broad.mit.edu	37	10	15151773	15151773	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr10:15151773C>G	uc001inz.1	-	11	1488	c.1404G>C	c.(1402-1404)AAG>AAC	p.K468N	NMT2_uc001ioa.1_Missense_Mutation_p.K455N|NMT2_uc009xjo.1_Intron|NMT2_uc010qbz.1_Missense_Mutation_p.K280N	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	468					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						CTATACCAAACTTGAGTTTTT	0.328000													14	91					0	0	0	0
OR52A4	390053	broad.mit.edu	37	11	5142746	5142746	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:5142746G>A	uc001lzz.1	-	1	63	c.63C>T	c.(61-63)ATC>ATT	p.I21I	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAAACCGGGGATCCCAATAA	0.418000													24	119					0	0	0	0
OR5F1	338674	broad.mit.edu	37	11	55761646	55761646	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:55761646C>A	uc010riv.1	-	1	456	c.456G>T	c.(454-456)GGG>GGT	p.G152G		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGTTCAGCAACCCTGCAGCAA	0.507000													11	60					9.70103e-10	5.40486e-09	1	0
GLYATL1	92292	broad.mit.edu	37	11	58723492	58723492	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:58723492C>G	uc001nnf.2	+	8	1277	c.901C>G	c.(901-903)CCA>GCA	p.P301A	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.P332A|GLYATL1_uc001nni.1_Missense_Mutation_p.P301A|GLYATL1_uc001nnj.1_Missense_Mutation_p.P301A			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	301						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GAATCTAGTTCCATTTTAGAC	0.388000													3	86					0	0	0	0
POLR2G	5436	broad.mit.edu	37	11	62532822	62532822	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:62532822C>T	uc001nva.2	+	5	454	c.344C>T	c.(343-345)TCA>TTA	p.S115L	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	115					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						TCCATCCCTTCAGAGATGGAG	0.458000													28	288					0	0	0	0
NXF1	10482	broad.mit.edu	37	11	62569082	62569082	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:62569082C>T	uc001nvf.1	-	7	797	c.661G>A	c.(661-663)GAT>AAT	p.D221N	NXF1_uc001nvg.1_Missense_Mutation_p.D221N|NXF1_uc009yog.1_Missense_Mutation_p.D264N|NXF1_uc010rmh.1_Missense_Mutation_p.D84N	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	221	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGGGAGCCATCGTATCGTTTG	0.507000													18	170					0	0	0	0
EHD1	10938	broad.mit.edu	37	11	64627443	64627443	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:64627443C>A	uc001obu.1	-	3	1123	c.868G>T	c.(868-870)GCC>TCC	p.A290S	EHD1_uc001obv.1_Missense_Mutation_p.A290S|EHD1_uc010rnq.1_Missense_Mutation_p.A304S	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	290					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						TTCCTGAGGGCGGCGTTTCGG	0.637000													46	32					3.21987e-24	1.90528e-23	1	0
ALKBH8	91801	broad.mit.edu	37	11	107431547	107431547	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:107431547C>T	uc010rvr.1	-	2	148	c.73G>A	c.(73-75)GCC>ACC	p.A25T	ALKBH8_uc009yxp.2_Missense_Mutation_p.A25T|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	25					response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		GTATGCTTGGCTTTAATCTGT	0.348000													13	29					0	0	0	0
OR4D5	219875	broad.mit.edu	37	11	123811175	123811175	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:123811175T>C	uc001pzk.1	+	1	852	c.852T>C	c.(850-852)CCT>CCC	p.P284P		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGCTGAATCCTGCCATCTATA	0.502000													22	86					0	0	0	0
C3AR1	719	broad.mit.edu	37	12	8211391	8211391	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:8211391C>T	uc001qtv.1	-	2	1483	c.1391G>A	c.(1390-1392)CGT>CAT	p.R464H		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	464	Cytoplasmic (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		GTGGGTGGAACGTGTGAGCTC	0.473000													34	91					0	0	0	0
PHC1	1911	broad.mit.edu	37	12	9092018	9092018	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:9092018A>T	uc001qvd.2	+	15	3134	c.2978A>T	c.(2977-2979)AAG>ATG	p.K993M	PHC1_uc001qve.2_Missense_Mutation_p.K993M	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	993	SAM.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CCTGCCCTCAAGATCTGCGCC	0.488000													13	14					0	0	0	0
PZP	5858	broad.mit.edu	37	12	9353588	9353588	+	Silent	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:9353588G>C	uc001qvl.2	-	6	599	c.570C>G	c.(568-570)TCC>TCG	p.S190S	PZP_uc009zgl.2_Silent_p.S59S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGAGGGGAAAGGACAACTGAT	0.498000													27	130					0	0	0	0
PRB4	5545	broad.mit.edu	37	12	11461798	11461798	+	Missense_Mutation	SNP	C	T	T	rs77336955		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:11461798C>T	uc001qzf.1	-	3	153	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PRB4_uc001qzt.2_Missense_Mutation_p.R40H	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	40	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|1.					extracellular region				ovary(1)	1						TCCTTGTGGGCGTCGTCCTTC	0.552000										HNSCC(22;0.051)			33	444					0	0	0	0
DNM1L	10059	broad.mit.edu	37	12	32886735	32886735	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:32886735T>C	uc001rld.2	+	13	1694	c.1533T>C	c.(1531-1533)AAT>AAC	p.N511N	DNM1L_uc001rle.2_Silent_p.N511N|DNM1L_uc001rlf.2_Silent_p.N511N|DNM1L_uc010skh.1_Silent_p.N577N|DNM1L_uc001rlg.2_Silent_p.N577N|DNM1L_uc001rlh.2_Silent_p.N564N|DNM1L_uc010ski.1_Silent_p.N308N	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	511	Interaction with GSK3B.|B domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGAACAATAATATAGAGGTAA	0.303000													53	148					0	0	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46315837	46315837	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:46315837T>C	uc001rox.2	-	15	4673	c.4386A>G	c.(4384-4386)ATA>ATG	p.I1462M	SFRS2IP_uc001row.2_Missense_Mutation_p.I1147M	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1462					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTTCAGCCTATGTTTTTTT	0.378000													3	148					0	0	0	0
OR6C1	390321	broad.mit.edu	37	12	55714812	55714812	+	Silent	SNP	T	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:55714812T>G	uc010spi.1	+	1	429	c.429T>G	c.(427-429)GTT>GTG	p.V143V		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						CACTGCTTGTTTTTACTTCTT	0.408000													6	22					0	0	0	0
COQ10A	93058	broad.mit.edu	37	12	56663287	56663287	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:56663287T>C	uc001sko.3	+	4	779	c.518T>C	c.(517-519)ATT>ACT	p.I173T	COQ10A_uc001skp.3_Missense_Mutation_p.I141T|COQ10A_uc001skq.3_Missense_Mutation_p.I156T	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	173						mitochondrial inner membrane				ovary(1)	1						TTAGAGACTATTTGGCGATTC	0.438000													22	143					0	0	0	0
LEMD3	23592	broad.mit.edu	37	12	65564805	65564805	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:65564805C>G	uc001ssl.1	+	1	1435	c.1429C>G	c.(1429-1431)CTC>GTC	p.L477V	LEMD3_uc009zqo.1_Missense_Mutation_p.L477V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	477	Helical; (Potential).				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTCGATGTTTCTCTTAACTGC	0.478000													23	38					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81777935	81777935	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:81777935A>T	uc001szo.1	-	9	1012	c.851T>A	c.(850-852)ATG>AAG	p.M284K	PPFIA2_uc010sue.1_Missense_Mutation_p.M184K|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	210										ovary(3)|lung(2)|pancreas(1)	6						CATCTGGGCCATTTCATAGTT	0.413000													10	25					0	0	0	0
TMTC3	160418	broad.mit.edu	37	12	88589416	88589416	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:88589416A>G	uc001tau.2	+	14	2955	c.2735A>G	c.(2734-2736)AAT>AGT	p.N912S		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	913						integral to membrane	binding			skin(1)	1						CGTATTTTAAATGGTGAATAA	0.333000													12	50					0	0	0	0
TXNRD1	7296	broad.mit.edu	37	12	104732985	104732985	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:104732985G>A	uc010swk.1	+	16	1837	c.1815G>A	c.(1813-1815)GCG>GCA	p.A605A	TXNRD1_uc010swl.1_Silent_p.A455A|TXNRD1_uc010swm.1_Silent_p.A507A|TXNRD1_uc010swn.1_Silent_p.A455A|TXNRD1_uc010swo.1_Silent_p.A455A|TXNRD1_uc010swp.1_Silent_p.A417A|TXNRD1_uc010swq.1_Silent_p.A505A|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Silent_p.A521A	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	605					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TTGCAGCTGCGCTCAAATGTG	0.433000													9	29					0	0	0	0
RIMBP2	23504	broad.mit.edu	37	12	130921489	130921489	+	Silent	SNP	T	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:130921489T>G	uc001uil.2	-	10	2117	c.1953A>C	c.(1951-1953)TCA>TCC	p.S651S	RIMBP2_uc001uim.2_Silent_p.S559S|RIMBP2_uc001uin.1_Silent_p.S310S	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	651	Pro-rich.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGCGGCTGGGTGAGGGCGACC	0.726000													6	18					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19412920	19412920	+	RNA	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:19412920T>C	uc010tcj.1	-	1		c.33190A>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AGATCTTTCATTTCTTCATGA	0.279000													3	127					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19415849	19415849	+	RNA	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:19415849T>A	uc010tcj.1	-	1		c.30261A>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						ATTTCCTTCTTTGACCtttaa	0.249000													4	19					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23910945	23910945	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:23910945T>A	uc001uon.2	-	10	7659	c.7070A>T	c.(7069-7071)GAA>GTA	p.E2357V	SACS_uc001uoo.2_Missense_Mutation_p.E2210V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2357					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGAAACCTTTTCTGAGTCAAC	0.333000													25	50					0	0	0	0
FOXO1	2308	broad.mit.edu	37	13	41134865	41134865	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:41134865C>T	uc001uxl.3	-	2	1148	c.763G>A	c.(763-765)GCA>ACA	p.A255T	FOXO1_uc010acc.1_Missense_Mutation_p.A70T	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	255					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TCCATGGATGCAGCTCTTCTC	0.517000													18	149					0	0	0	0
TSC22D1	8848	broad.mit.edu	37	13	45148997	45148997	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:45148997G>A	uc001uzn.3	-	1	1705	c.1214C>T	c.(1213-1215)TCG>TTG	p.S405L	TSC22D1_uc001uzo.1_Missense_Mutation_p.S405L	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	405					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCTGAACCTCGAAGTGTTAAC	0.438000													25	83					0	0	0	0
OLFM4	10562	broad.mit.edu	37	13	53608558	53608558	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:53608558T>A	uc001vhl.2	+	2	280	c.280T>A	c.(280-282)TTT>ATT	p.F94I	OLFM4_uc001vhk.1_Missense_Mutation_p.F94I	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	94					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		AGACACCACCTTTCCCGTGGA	0.443000													10	84					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60413536	60413536	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:60413536C>A	uc001vht.2	-	23	3003	c.2784G>T	c.(2782-2784)CAG>CAT	p.Q928H	DIAPH3_uc001vhu.2_Missense_Mutation_p.Q665H	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	928	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GCTGTTGAAGCTGCCTTCCCA	0.383000													16	38					1.15088e-07	6.37066e-07	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455394	84455394	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:84455394A>T	uc001vlk.2	-	1	1135	c.249T>A	c.(247-249)AAT>AAA	p.N83K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	83	Extracellular (Potential).|LRR 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AACTAACCGCATTATAAAAGT	0.463000													31	65					0	0	0	0
COL4A2	1284	broad.mit.edu	37	13	111102707	111102707	+	Silent	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:111102707C>G	uc001vqx.2	+	20	1534	c.1245C>G	c.(1243-1245)CCC>CCG	p.P415P		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	415	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCGGAGACCCCGGCATCCCTG	0.637000													3	81					0	0	0	0
NID2	22795	broad.mit.edu	37	14	52520462	52520462	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:52520462G>T	uc001wzo.2	-	5	1498	c.1264C>A	c.(1264-1266)CCC>ACC	p.P422T	NID2_uc010tqs.1_Missense_Mutation_p.P422T|NID2_uc010tqt.1_Missense_Mutation_p.P422T|NID2_uc001wzp.2_Missense_Mutation_p.P422T	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	422						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TCTGGGTAGGGCTGGATGCTT	0.552000													23	59					1.10513e-12	6.2795e-12	1	0
SYNE2	23224	broad.mit.edu	37	14	64468762	64468762	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:64468762A>T	uc001xgm.2	+	29	3979	c.3749A>T	c.(3748-3750)CAT>CTT	p.H1250L	SYNE2_uc001xgl.2_Missense_Mutation_p.H1250L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1250	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGGATTTCATCTCATTGAT	0.418000													33	81					0	0	0	0
C14orf179	112752	broad.mit.edu	37	14	76549919	76549919	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:76549919G>C	uc010asm.1	+	9	660	c.626G>C	c.(625-627)TGA>TCA	p.*209S	C14orf179_uc001xsg.2_Nonstop_Mutation_p.*214S|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	209					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		AGGCACACCTGAGCCCGTCAC	0.507000													6	57					0	0	0	0
ESRRB	2103	broad.mit.edu	37	14	76957942	76957942	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:76957942C>T	uc001xsq.1	+	6	1007	c.940C>T	c.(940-942)CTC>TTC	p.L314F	ESRRB_uc001xsr.2_Missense_Mutation_p.L314F|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	314						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GCACTCCCGCCTCGCGGGGCT	0.592000													4	9					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88945598	88945598	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:88945598C>G	uc001xwv.3	-	13	2508	c.2177G>C	c.(2176-2178)CGG>CCG	p.R726P	PTPN21_uc010twc.1_Missense_Mutation_p.R522P	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	726						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						AGGAGGCGCCCGGGCCCCGCT	0.701000													3	20					0	0	0	0
Unknown	0	broad.mit.edu	37	15	20649492	20649492	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:20649492C>G	uc001ytg.2	-	18	2726	c.2017G>C	c.(2017-2019)GAG>CAG	p.E673Q	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.E673Q|uc010tyy.1_Missense_Mutation_p.E673Q					RecName: Full=Putative HERC2-like protein 3;																		GAGTCGTCCTCTGTGTCCGAA	0.562000													38	137					0	0	0	0
Unknown	0	broad.mit.edu	37	15	22473131	22473131	+	RNA	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:22473131G>T	uc001yuj.1	-	2		c.140C>A								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		ACTGCTGATGGAGCCACCAGA	0.612000													29	153					3.73988e-18	2.18287e-17	1	0
MAGEL2	54551	broad.mit.edu	37	15	23889583	23889583	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:23889583A>G	uc001ywj.3	-	1	1593	c.1498T>C	c.(1498-1500)TCC>CCC	p.S500P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TCTAAATAGGATGCCACCAAA	0.423000													5	40					0	0	0	0
NDN	4692	broad.mit.edu	37	15	23931584	23931584	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:23931584A>G	uc001ywk.2	-	1	867	c.781T>C	c.(781-783)TTT>CTT	p.F261L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	261	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GAGCCCCAAAAGAACTCGTAT	0.572000									Prader-Willi_syndrome				5	56					0	0	0	0
PYGO1	26108	broad.mit.edu	37	15	55838317	55838317	+	Silent	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:55838317T>A	uc010bfl.1	-	3	1220	c.1164A>T	c.(1162-1164)GCA>GCT	p.A388A	PYGO1_uc002adf.1_Silent_p.A388A	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	388	PHD-type.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGCCCCATACTGCAGATGCTT	0.448000													25	60					0	0	0	0
LRRC28	123355	broad.mit.edu	37	15	99901641	99901641	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:99901641G>A	uc002bva.1	+	8	951	c.796G>A	c.(796-798)GAG>AAG	p.E266K	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.E112K|LRRC28_uc010urt.1_Missense_Mutation_p.E80K|LRRC28_uc002bvc.1_Missense_Mutation_p.E266K|LRRC28_uc010uru.1_Missense_Mutation_p.E197K|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	266											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CATAGGGACGGAGCATGATCA	0.522000											OREG0023509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	63					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18875116	18875116	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr16:18875116T>C	uc002dfm.2	-	25	3914	c.3551A>G	c.(3550-3552)AAT>AGT	p.N1184S	SMG1_uc010bwb.2_Missense_Mutation_p.N1044S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1184	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TCCTAAATAATTTATAACCTC	0.403000													13	36					0	0	0	0
CHST4	10164	broad.mit.edu	37	16	71570812	71570812	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr16:71570812G>A	uc002fan.2	+	2	413	c.232G>A	c.(232-234)GTG>ATG	p.V78M	CHST4_uc002fao.2_Missense_Mutation_p.V78M	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	78	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						CGCCTGGCACGTGTGGATGAC	0.577000													30	62					0	0	0	0
OR1A2	26189	broad.mit.edu	37	17	3101177	3101177	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:3101177G>A	uc002fvd.1	+	1	365	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCATACGATCGAGCTGTGGCC	0.483000													32	60					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	21					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7752094	7752094	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:7752094G>A	uc002giw.1	+	11	2864	c.2488G>A	c.(2488-2490)GGG>AGG	p.G830R	KDM6B_uc002gix.2_Missense_Mutation_p.G132R	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	830	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CACCCGGCCTGGGCCCTTGCC	0.657000													9	131					0	0	0	0
ICAM2	3384	broad.mit.edu	37	17	62081229	62081229	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:62081229G>T	uc002jdu.3	-	3	656	c.424C>A	c.(424-426)CTG>ATG	p.L142M	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.L142M|ICAM2_uc010ded.2_Missense_Mutation_p.L142M|ICAM2_uc002jdx.3_Missense_Mutation_p.L142M|ICAM2_uc002jdv.3_Missense_Mutation_p.L142M	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	142	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						AGGCTGTCCAGGGGCTCCACG	0.607000													7	45					0.000157383	0.000833549	1	0
MAPK4	5596	broad.mit.edu	37	18	48252451	48252451	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr18:48252451C>T	uc002lev.2	+	5	1973	c.973C>T	c.(973-975)CAA>TAA	p.Q325*	MAPK4_uc010xdm.1_Nonsense_Mutation_p.Q114*|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	325					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GCCCACCTCACAACACCCCTT	0.582000													36	31					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64172067	64172067	+	Silent	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr18:64172067T>A	uc002lkc.1	-	12	2439	c.2301A>T	c.(2299-2301)GCA>GCT	p.A767A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	767	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTGACTGCACTGCAGAACCAA	0.368000													18	19					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8191467	8191467	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:8191467C>T	uc002mjf.2	-	19	2460	c.2439G>A	c.(2437-2439)TGG>TGA	p.W813*		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	813	TB 4.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGATCTTCAGCCAGCAGGTGC	0.677000													6	12					0	0	0	0
OR10H2	26538	broad.mit.edu	37	19	15839701	15839701	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:15839701C>T	uc002nbm.2	+	1	868	c.848C>T	c.(847-849)ACG>ATG	p.T283M		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCAGTCCTCACGCCCTTCCTC	0.547000													29	119					0	0	0	0
MEF2B	100271849	broad.mit.edu	37	19	19260222	19260222	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:19260222C>G	uc002nlm.2	-	3	185	c.71G>C	c.(70-72)CGG>CCG	p.R24P	MEF2B_uc002nln.2_Missense_Mutation_p.R71P|MEF2B_uc002nll.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R24P|MEF2B_uc002nlk.2_Missense_Mutation_p.R24P	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			CCCGAACTTCCGCTTGGTGAA	0.562000													16	54					0	0	0	0
ZNF43	7594	broad.mit.edu	37	19	21990434	21990434	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:21990434G>A	uc002nqj.2	-	4	2535	c.2405C>T	c.(2404-2406)CCT>CTT	p.P802L	ZNF43_uc010ecv.2_Missense_Mutation_p.P796L|ZNF43_uc002nql.2_Missense_Mutation_p.P796L|ZNF43_uc002nqm.2_Missense_Mutation_p.P796L|ZNF43_uc002nqk.2_Missense_Mutation_p.P732L	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AAAAGTTTGAGGTGTTGTCAA	0.313000													9	43					0	0	0	0
NR1H2	7376	broad.mit.edu	37	19	50881485	50881485	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:50881485C>T	uc010enw.2	+	5	537	c.261C>T	c.(259-261)TGC>TGT	p.C87C	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Silent_p.C87C|NR1H2_uc002psa.3_Intron	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	87	Nuclear receptor.|NR C4-type.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		ACGAGCTTTGCCGTGTCTGTG	0.637000													5	161					0	0	0	0
CEACAM18	729767	broad.mit.edu	37	19	51984689	51984689	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:51984689T>C	uc002pwv.1	+	4	626	c.626T>C	c.(625-627)CTG>CCG	p.L209P		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	209						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCCAGCTCCCTGGTGGAGAAC	0.507000													27	23					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415923	15415923	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:15415923C>T	uc002rcc.1	-	44	5435	c.5409G>A	c.(5407-5409)CTG>CTA	p.L1803L	NBAS_uc010exl.1_Silent_p.L875L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1803										ovary(2)|liver(1)|skin(1)	4						TTTCATCTGTCAGCTTTTTGT	0.363000													6	93					0	0	0	0
AGBL5	60509	broad.mit.edu	37	2	27278036	27278036	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:27278036C>T	uc002rie.2	+	6	1040	c.823C>T	c.(823-825)CCC>TCC	p.P275S	AGBL5_uc002ric.2_Missense_Mutation_p.P275S|AGBL5_uc002rid.2_Missense_Mutation_p.P275S|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	275					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTGATGATCCCCGGGCCCA	0.537000													29	189					0	0	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													4	13					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116510763	116510763	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:116510763A>C	uc002tla.1	+	11	1421	c.964A>C	c.(964-966)ACT>CCT	p.T322P	DPP10_uc002tlb.1_Missense_Mutation_p.T272P|DPP10_uc002tlc.1_Missense_Mutation_p.T318P|DPP10_uc002tle.2_Missense_Mutation_p.T326P|DPP10_uc002tlf.1_Missense_Mutation_p.T315P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	322	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACTATATCACTATGGTTAA	0.358000													5	34					0	0	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111147	136111147	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:136111147C>G	uc002tum.2	-	4	349	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.E78Q|ZRANB3_uc002tun.1_Missense_Mutation_p.E18Q	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	78	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GGCCATTCCTCTTTATAGAAG	0.318000													3	44					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141299370	141299370	+	Silent	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:141299370A>T	uc002tvj.1	-	44	8337	c.7365T>A	c.(7363-7365)GCT>GCA	p.A2455A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2455	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTGGCAACAGCTATGATTC	0.363000										TSP Lung(27;0.18)			9	137					0	0	0	0
KCNH7	90134	broad.mit.edu	37	2	163228467	163228467	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:163228467G>T	uc002uch.1	-	16	3675	c.3463C>A	c.(3463-3465)CAC>AAC	p.H1155N		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1155	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGCCGCAGGTGAAGCTCTAAA	0.428000													8	47					1.12685e-05	6.04274e-05	1	0
SCN1A	6323	broad.mit.edu	37	2	166901572	166901572	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:166901572C>G	uc010zcz.1	-	10	1661	c.1643G>C	c.(1642-1644)AGG>ACG	p.R548T	SCN1A_uc002udo.3_Missense_Mutation_p.R417T|SCN1A_uc010fpk.2_Missense_Mutation_p.R417T	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	548						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGAGGAGTACCTCTTTTCATA	0.433000													44	82					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9364994	9364994	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:9364994G>A	uc002wnf.2	+	13	1136	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	PLCB4_uc010gbw.1_Missense_Mutation_p.G334S|PLCB4_uc010gbx.2_Missense_Mutation_p.G334S|PLCB4_uc002wne.2_Missense_Mutation_p.G334S|PLCB4_uc002wnh.2_Missense_Mutation_p.G181S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	334	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTATCTCACTGGCAGACAGTT	0.463000													35	71					0	0	0	0
PLK1S1	55857	broad.mit.edu	37	20	21143094	21143094	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:21143094G>A	uc002wsb.2	+	5	1121	c.988G>A	c.(988-990)GAA>AAA	p.E330K	PLK1S1_uc010zsh.1_Missense_Mutation_p.E227K|PLK1S1_uc010zsi.1_Missense_Mutation_p.E197K|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	330					spindle organization	centrosome	protein kinase binding				0						AGAATACTGTGAATCTGAAAA	0.468000													8	20					0	0	0	0
NKX2-4	644524	broad.mit.edu	37	20	21377938	21377938	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:21377938C>T	uc010gcz.2	-	1	110	c.100G>A	c.(100-102)GCG>ACG	p.A34T		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	34					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccgggtggcgcgccgTCCATG	0.517000													4	7					0	0	0	0
NINL	22981	broad.mit.edu	37	20	25459583	25459583	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:25459583T>C	uc002wux.1	-	16	2251	c.2177A>G	c.(2176-2178)CAT>CGT	p.H726R	NINL_uc010gdn.1_Missense_Mutation_p.H726R|NINL_uc010gdo.1_Missense_Mutation_p.H509R	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	726					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTGGCTGTGATGCCGCAGGGC	0.582000													33	73					0	0	0	0
GSS	2937	broad.mit.edu	37	20	33524591	33524591	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:33524591G>A	uc002xbg.2	-	8	822	c.742C>T	c.(742-744)CTG>TTG	p.L248L	GSS_uc010zun.1_Silent_p.L120L|GSS_uc010zuo.1_Silent_p.L137L|GSS_uc010zup.1_Silent_p.L179L|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	248					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TCTTGGTCCAGAGACCCCTTT	0.473000													43	226					0	0	0	0
EEF1A2	1917	broad.mit.edu	37	20	62122079	62122079	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:62122079G>A	uc002yfd.1	-	5	883	c.782C>T	c.(781-783)ACG>ATG	p.T261M	EEF1A2_uc002yfe.1_Missense_Mutation_p.T261M|EEF1A2_uc010gkg.1_Missense_Mutation_p.T261M	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	261						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CACGGGCACCGTGCCAATGCC	0.647000													18	41					0	0	0	0
Unknown	0	broad.mit.edu	37	21	10862909	10862909	+	IGR	SNP	T	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr21:10862909T>G								None (None upstream) : TPTE (43834 downstream)																							GTGGATGGGATTGGTGTGCCC	0.542000													11	239					0	0	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20127041	20127041	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr22:20127041G>A	uc002zrq.2	+	3	373	c.267G>A	c.(265-267)CCG>CCA	p.P89P	ZDHHC8_uc002zrr.1_Silent_p.P89P|ZDHHC8_uc010gsa.2_5'UTR	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	89	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TCCGGGCTCCGCTGTACAAGA	0.607000													61	44					0	0	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33885692	33885692	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr3:33885692A>C	uc003cfx.2	+	11	1603	c.1448A>C	c.(1447-1449)GAA>GCA	p.E483A	PDCD6IP_uc003cfy.2_Missense_Mutation_p.E488A|PDCD6IP_uc011axw.1_Missense_Mutation_p.E264A	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	483	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						CCATCCAATGAACTGTATAAG	0.343000													4	63					0	0	0	0
SDHAP1	255812	broad.mit.edu	37	3	195698262	195698262	+	RNA	SNP	C	G	G	rs28503679	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr3:195698262C>G	uc003fvx.3	-	11		c.1611G>C			SDHAP1_uc011btp.1_RNA	NR_003264				Homo sapiens full length insert cDNA clone ZC24D06.												0						AATTTGTCAACATTCGTGACA	0.418000													3	104					0	0	0	0
WDR53	348793	broad.mit.edu	37	3	196281606	196281606	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr3:196281606T>C	uc003fwt.2	-	4	1024	c.553A>G	c.(553-555)ATG>GTG	p.M185V		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	185										breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGGCCTTCCATTTCTTCTGTT	0.438000													80	288					0	0	0	0
CNGA1	1259	broad.mit.edu	37	4	47939078	47939078	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:47939078C>T	uc003gxt.3	-	11	1699	c.1433G>A	c.(1432-1434)CGC>CAC	p.R478H	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.R547H	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	478	Extracellular (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						AGCAAAAATGCGTACCTTTTT	0.378000													22	92					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956863	73956863	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:73956863T>A	uc003hgp.2	-	29	6599	c.6482A>T	c.(6481-6483)CAG>CTG	p.Q2161L	ANKRD17_uc003hgo.2_Missense_Mutation_p.Q2048L|ANKRD17_uc003hgq.2_Missense_Mutation_p.Q1910L|ANKRD17_uc003hgr.2_Missense_Mutation_p.Q2160L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2161					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTGGTGTCTGAGGCATAGG	0.532000													39	170					0	0	0	0
DMP1	1758	broad.mit.edu	37	4	88584472	88584472	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:88584472G>C	uc003hqv.2	+	6	1646	c.1542G>C	c.(1540-1542)TAG>TAC	p.*514Y	DMP1_uc003hqw.2_Nonstop_Mutation_p.*498Y	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	514					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		ACGGCTATTAGCATCAGCTGT	0.373000													32	134					0	0	0	0
PDHA2	5161	broad.mit.edu	37	4	96761919	96761919	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:96761919C>T	uc003htr.3	+	1	681	c.618C>T	c.(616-618)TTC>TTT	p.F206F		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	206					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCGAAGCTTTCAATATGGCAG	0.443000													14	49					0	0	0	0
C4orf31	79625	broad.mit.edu	37	4	121958183	121958183	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:121958183A>T	uc003idq.1	-	4	1470	c.943T>A	c.(943-945)TTT>ATT	p.F315I		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	315	Fibronectin type-III 1.										0						TTGACCACAAATACATCAAAG	0.453000													15	71					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79027402	79027402	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:79027402T>C	uc003kgc.2	+	2	2886	c.2814T>C	c.(2812-2814)GAT>GAC	p.D938D		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	938						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGAAGAAGATCAAGAAGACA	0.413000													48	39					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90041015	90041015	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:90041015C>G	uc003kju.2	+	51	10798	c.10702C>G	c.(10702-10704)CTA>GTA	p.L3568V	GPR98_uc003kjt.2_Missense_Mutation_p.L1274V|GPR98_uc003kjv.2_Missense_Mutation_p.L1168V	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3568	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTAATAGCTCTAGTGGGAGC	0.368000													40	134					0	0	0	0
CYFIP2	26999	broad.mit.edu	37	5	156741393	156741393	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:156741393G>A	uc003lwq.2	+	14	1290	c.1152G>A	c.(1150-1152)GAG>GAA	p.E384E	CYFIP2_uc011ddn.1_Silent_p.E358E|CYFIP2_uc011ddo.1_Silent_p.E188E|CYFIP2_uc003lwr.2_Silent_p.E384E|CYFIP2_uc003lws.2_Silent_p.E384E|CYFIP2_uc003lwt.2_Silent_p.E262E|CYFIP2_uc011ddp.1_Silent_p.E118E	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	384					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTCAGACGAGGAGTATCGCG	0.517000													22	35					0	0	0	0
FGFR4	2264	broad.mit.edu	37	5	176519733	176519733	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:176519733A>G	uc003mfl.2	+	8	1172	c.1005A>G	c.(1003-1005)GCA>GCG	p.A335A	FGFR4_uc003mfm.2_Silent_p.A335A|FGFR4_uc011dfu.1_Silent_p.A335A|FGFR4_uc011dfw.1_Silent_p.A335A|FGFR4_uc003mfo.2_Silent_p.A335A	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	335	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTGCCTCGCAGGCAATTCCA	0.637000										TSP Lung(9;0.080)			23	31					0	0	0	0
PRPF4B	8899	broad.mit.edu	37	6	4037761	4037761	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:4037761C>T	uc003mvv.2	+	3	1460	c.1369C>T	c.(1369-1371)CGT>TGT	p.R457C	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	457	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CCCACTCAGACGTAGCAGGTC	0.448000													20	41					0	0	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26205025	26205025	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:26205025C>A	uc003ngy.2	+	1	153	c.153C>A	c.(151-153)ATC>ATA	p.I51I		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				CTGGTCTCATCTACGAGGAGA	0.562000													38	68					6.99958e-10	3.92525e-09	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27834842	27834842	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:27834842G>C	uc003njx.2	-	1	518	c.466C>G	c.(466-468)CCG>GCG	p.P156A		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	156					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						GCCTTCTTCGGAGTCTTCTTC	0.602000													5	231					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283873	33283873	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:33283873G>A	uc003oeb.2	-	2	973	c.821C>T	c.(820-822)GCA>GTA	p.A274V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.A274V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGAACCACTGCCCCCCTCCC	0.607000													12	45					0	0	0	0
BYSL	705	broad.mit.edu	37	6	41889501	41889501	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:41889501G>C	uc003orl.2	+	1	537	c.201G>C	c.(199-201)GAG>GAC	p.E67D	MED20_uc003orj.2_5'Flank|MED20_uc003ork.2_5'Flank|MED20_uc011duh.1_5'Flank|MED20_uc011dui.1_5'Flank|MED20_uc011duj.1_5'Flank	NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	67					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCAACAGGAGGAACTCGAGG	0.677000											OREG0017436	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	26					0	0	0	0
PRIM2	5558	broad.mit.edu	37	6	57512691	57512691	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:57512691G>A	uc003pdx.2	+	15	1606	c.1519G>A	c.(1519-1521)GAA>AAA	p.E507K		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	507					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTACTTTAGTGAAGATTCTTA	0.333000													16	473					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83849755	83849755	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:83849755G>A	uc003pjs.1	+	22	5417	c.5157G>A	c.(5155-5157)ATG>ATA	p.M1719I	DOPEY1_uc011dyy.1_Missense_Mutation_p.M1710I|DOPEY1_uc010kbl.1_Missense_Mutation_p.M1710I|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1719					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CACCAGATATGATTCTTACTC	0.338000													9	41					0	0	0	0
PGM3	5238	broad.mit.edu	37	6	83896760	83896760	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:83896760C>T	uc003pjv.2	-	4	464	c.424G>A	c.(424-426)GAT>AAT	p.D142N	PGM3_uc003pjw.2_Missense_Mutation_p.D61N|PGM3_uc011dyz.1_Missense_Mutation_p.D170N	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	142					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		GTCACACCATCTATTACAGAT	0.328000													20	61					0	0	0	0
RRAGD	58528	broad.mit.edu	37	6	90097155	90097155	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:90097155G>T	uc003pnd.3	-	2	586	c.303C>A	c.(301-303)TGC>TGA	p.C101*	RRAGD_uc010kcc.2_Intron	NM_021244	NP_067067	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	101					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			ovary(2)|central_nervous_system(1)	3		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CATCTTCCCGGCATATCTTAT	0.428000													98	190					5.01286e-43	2.98683e-42	1	0
WASF1	8936	broad.mit.edu	37	6	110421867	110421867	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:110421867T>C	uc003ptv.1	-	11	2375	c.1538A>G	c.(1537-1539)AAA>AGA	p.K513R	WASF1_uc003ptw.1_Missense_Mutation_p.K513R|WASF1_uc003ptx.1_Missense_Mutation_p.K513R|WASF1_uc003pty.1_Missense_Mutation_p.K513R	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	513	WH2.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CTCTTCTACTTTGCGTAGCTG	0.363000													14	27					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117724426	117724426	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:117724426C>T	uc003pxp.1	-	6	652	c.453G>A	c.(451-453)CCG>CCA	p.P151P	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	151	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCACATAGGACGGTCTGGACA	0.473000			T	GOPC|ROS1	glioblastoma|NSCLC								11	26					0	0	0	0
PTPRK	5796	broad.mit.edu	37	6	128404886	128404886	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:128404886G>C	uc003qbk.2	-	9	1916	c.1549C>G	c.(1549-1551)CCA>GCA	p.P517A	PTPRK_uc003qbj.2_Missense_Mutation_p.P517A|PTPRK_uc010kfc.2_Missense_Mutation_p.P517A|PTPRK_uc011ebu.1_Missense_Mutation_p.P517A|PTPRK_uc003qbl.1_Missense_Mutation_p.P387A|PTPRK_uc011ebv.1_Missense_Mutation_p.P517A	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	517	Extracellular (Potential).|Fibronectin type-III 3.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTCCATTTGGATCCAAAGGT	0.368000													23	99					0	0	0	0
REPS1	85021	broad.mit.edu	37	6	139266690	139266690	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:139266690T>C	uc003qii.2	-	3	1001	c.422A>G	c.(421-423)AAG>AGG	p.K141R	REPS1_uc003qig.3_Missense_Mutation_p.K141R|REPS1_uc011edr.1_Missense_Mutation_p.K141R|REPS1_uc003qij.2_Missense_Mutation_p.K141R|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	141						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TACGGATCCCTTTTTCACTTG	0.478000													3	138					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11675953	11675953	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:11675953T>A	uc003ssf.3	-	2	1078	c.826A>T	c.(826-828)AGA>TGA	p.R276*		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	276	Extracellular (Potential).|Potential.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTCCCGCGTCTCCTTGCTTGT	0.537000										HNSCC(18;0.044)			32	95					0	0	0	0
STK31	56164	broad.mit.edu	37	7	23825129	23825129	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:23825129A>G	uc003sws.3	+	18	2248	c.2181A>G	c.(2179-2181)GAA>GAG	p.E727E	STK31_uc003swt.3_Silent_p.E704E|STK31_uc011jze.1_Silent_p.E727E|STK31_uc010kuq.2_Silent_p.E704E|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	727	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TGAGCTTGGAACGAGATCTTC	0.403000													35	90					0	0	0	0
NPC1L1	29881	broad.mit.edu	37	7	44556434	44556434	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:44556434G>A	uc003tlb.2	-	17	3524	c.3468C>T	c.(3466-3468)CTC>CTT	p.L1156L	NPC1L1_uc003tlc.2_Silent_p.L1129L|NPC1L1_uc011kbw.1_Silent_p.L1083L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1156	Helical; Name=10; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GGCCCAGCAGGAGGCAGGAGA	0.592000													14	42					0	0	0	0
EGFR	1956	broad.mit.edu	37	7	55210124	55210124	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:55210124C>G	uc003tqk.2	+	2	480	c.234C>G	c.(232-234)TTC>TTG	p.F78L	EGFR_uc003tqh.2_Missense_Mutation_p.F78L|EGFR_uc003tqi.2_Missense_Mutation_p.F78L|EGFR_uc003tqj.2_Missense_Mutation_p.F78L|EGFR_uc010kzg.1_Missense_Mutation_p.F78L|EGFR_uc011kco.1_Missense_Mutation_p.F25L	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	78	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATCTTTCCTTCTTAAAGGTTG	0.378000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	869					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57188238	57188238	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:57188238C>G	uc010kzo.2	-	5	1155	c.884G>C	c.(883-885)AGA>ACA	p.R295T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTTGTAGGGTCTCTCTCCAGT	0.473000													6	70					0	0	0	0
POM121	9883	broad.mit.edu	37	7	72413634	72413634	+	Silent	SNP	G	A	A	rs139238552	byFrequency	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:72413634G>A	uc003twk.2	+	11	3102	c.3102G>A	c.(3100-3102)ACG>ACA	p.T1034T	POM121_uc003twj.2_Silent_p.T769T|POM121_uc010lam.1_Silent_p.T769T	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1034	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				GCGGTGCCACGCACTCGGCGT	0.652000													18	154					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87913172	87913172	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:87913172G>C	uc003ujs.2	-	2	518	c.413C>G	c.(412-414)TCA>TGA	p.S138*	STEAP4_uc010lek.2_Nonsense_Mutation_p.S138*|STEAP4_uc003ujt.2_Nonsense_Mutation_p.S138*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	138					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					AGCCCAGGCTGAGATGGTGTT	0.418000													404	101					0	0	0	0
Unknown	0	broad.mit.edu	37	7	100551902	100551903	+	RNA	DNP	GG	TT	TT			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:100551902_100551903GG>TT	uc003uxk.1	+	1		c.1153_1154GG>TT			uc003uxl.1_Missense_Mutation_p.R118I					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		TCTTTCACTAGGGGAAGTACGT	0.436000													11	911					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100684124	100684124	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:100684124C>A	uc003uxp.1	+	3	9480	c.9427C>A	c.(9427-9429)CAT>AAT	p.H3143N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3143	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTGAAGCCCATTCATCTCC	0.498000													10	904					0.000308642	0.00162463	1	0
PIK3CG	5294	broad.mit.edu	37	7	106513012	106513012	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:106513012G>A	uc003vdv.3	+	3	2111	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T	PIK3CG_uc003vdu.2_Missense_Mutation_p.A676T|PIK3CG_uc003vdw.2_Missense_Mutation_p.A676T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	676					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCATGATAGCGCCCTTGCCAG	0.393000													78	116					0	0	0	0
DOCK5	80005	broad.mit.edu	37	8	25154152	25154152	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:25154152C>T	uc003xeg.2	+	7	731	c.594C>T	c.(592-594)ATC>ATT	p.I198I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_5'UTR|DOCK5_uc003xef.2_Silent_p.I198I	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	198						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGGAAAAGATCCAAGAAGAGA	0.448000													8	14					0	0	0	0
CDCA2	157313	broad.mit.edu	37	8	25365207	25365207	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:25365207C>G	uc003xep.1	+	15	3504	c.3025C>G	c.(3025-3027)CTG>GTG	p.L1009V	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.L994V|CDCA2_uc003xer.1_Missense_Mutation_p.L672V	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1009					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGAGAGCTCTCTGACTGCCTT	0.433000													15	99					0	0	0	0
KIAA0146	23514	broad.mit.edu	37	8	48614380	48614380	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:48614380A>G	uc003xqd.2	+	13	1880	c.1871A>G	c.(1870-1872)AAG>AGG	p.K624R	KIAA0146_uc011ldb.1_Missense_Mutation_p.K624R|KIAA0146_uc010lxs.2_Missense_Mutation_p.K99R|KIAA0146_uc011ldc.1_Missense_Mutation_p.K554R|KIAA0146_uc011ldd.1_Missense_Mutation_p.K564R|KIAA0146_uc003xqe.2_Missense_Mutation_p.K99R|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.K313R|KIAA0146_uc010lxt.2_Missense_Mutation_p.K313R|KIAA0146_uc011ldf.1_Missense_Mutation_p.K129R|KIAA0146_uc011ldg.1_Missense_Mutation_p.K114R|KIAA0146_uc010lxv.1_Missense_Mutation_p.K118R	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	624											0		Lung NSC(58;0.175)				CCCATTTATAAGCTTTACCAG	0.428000													91	170					0	0	0	0
TRPA1	8989	broad.mit.edu	37	8	72948640	72948640	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:72948640G>A	uc003xza.2	-	21	2613	c.2438C>T	c.(2437-2439)ACG>ATG	p.T813M	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	813	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GATGCCCGTCGTGTAGATAAT	0.363000													14	53					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104987601	104987601	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:104987601C>G	uc003yls.2	+	14	2369	c.2128C>G	c.(2128-2130)CTT>GTT	p.L710V	RIMS2_uc003ylp.2_Missense_Mutation_p.L932V|RIMS2_uc003ylw.2_Missense_Mutation_p.L724V|RIMS2_uc003ylq.2_Missense_Mutation_p.L724V|RIMS2_uc003ylr.2_Missense_Mutation_p.L771V|RIMS2_uc003ylt.2_Missense_Mutation_p.L317V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	994					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTCGAGATCTTCAAAGCTC	0.358000										HNSCC(12;0.0054)			8	29					0	0	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361225	105361225	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:105361225C>T	uc003ylx.1	+	2	494	c.445C>T	c.(445-447)CAG>TAG	p.Q149*		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	149					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGAGGCAATTCAGTGGATTTA	0.418000													14	84					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113988168	113988168	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:113988168C>A	uc003ynu.2	-	7	1399	c.1240G>T	c.(1240-1242)GGG>TGG	p.G414W	CSMD3_uc003ynt.2_Missense_Mutation_p.G374W|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	414	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGAGAGAGCCCGTCCTTGGAC	0.478000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	117					6.33239e-15	3.62213e-14	1	0
COL22A1	169044	broad.mit.edu	37	8	139601580	139601580	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:139601580G>A	uc003yvd.2	-	65	5244	c.4797C>T	c.(4795-4797)CCC>CCT	p.P1599P	COL22A1_uc011ljo.1_Silent_p.P879P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1599	Pro-rich.|Gly-rich.|Collagen-like 16.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGGGGACCGGGAGGTCCTG	0.622000										HNSCC(7;0.00092)			7	36					0	0	0	0
ZNF250	58500	broad.mit.edu	37	8	146107136	146107136	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:146107136C>G	uc003zeq.3	-	6	1564	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.E478Q|ZNF250_uc010mgg.2_Missense_Mutation_p.E478Q	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	483	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TTGCCACATTCTGTGCACTGG	0.552000													7	41					0	0	0	0
ZNF250	58500	broad.mit.edu	37	8	146107269	146107269	+	Silent	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:146107269C>G	uc003zeq.3	-	6	1431	c.1314G>C	c.(1312-1314)CTG>CTC	p.L438L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.L433L|ZNF250_uc010mgg.2_Silent_p.L433L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	438	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		GGTGCTGGATCAGGTGTGAGT	0.567000													11	62					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72131553	72131553	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:72131553C>T	uc004ahh.2	-	2	850	c.574G>A	c.(574-576)GGC>AGC	p.G192S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	192					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCCTGGAGGCCGCCGTAGTCG	0.687000													5	26					0	0	0	0
SYK	6850	broad.mit.edu	37	9	93650902	93650902	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:93650902A>G	uc004aqz.2	+	13	2033	c.1828A>G	c.(1828-1830)ACA>GCA	p.T610A	SYK_uc004ara.2_Missense_Mutation_p.T587A|SYK_uc004arb.2_Missense_Mutation_p.T587A|SYK_uc004arc.2_Missense_Mutation_p.T610A|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	610	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TCTGTGCTGGACATACGAGTG	0.463000			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								7	18					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	118997917	118997917	+	Splice_Site	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:118997917G>T	uc004bjn.2	+	7	3113	c.2732_splice	c.e7+1	p.M911_splice	PAPPA_uc011lxp.1_Splice_Site_p.M606_splice|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A						cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TCGTAGACATGTAAGTGCATT	0.507000													42	103					5.2432e-18	3.03964e-17	1	0
BAT2L1	84726	broad.mit.edu	37	9	134343088	134343088	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:134343088A>G	uc004can.3	+	12	1914	c.1859A>G	c.(1858-1860)TAT>TGT	p.Y620C	BAT2L1_uc010mzj.1_Missense_Mutation_p.Y203C	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	620	Gln-rich.						protein binding				0						GAGTTCAAGTATCAGAAGTCC	0.557000													20	45					0	0	0	0
ASMT	438	broad.mit.edu	37	X	1752052	1752052	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:1752052G>C	uc004cqd.2	+	8	801	c.656G>C	c.(655-657)GGA>GCA	p.G219A	ASMT_uc010ncy.2_Missense_Mutation_p.G219A|ASMT_uc004cqe.2_Intron	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	191					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTGGGGCTGGAGCTCTGGCT	0.537000													39	172					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811511	5811511	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:5811511A>G	uc010ndh.2	-	6	2299	c.1798T>C	c.(1798-1800)TTG>CTG	p.L600L	NLGN4X_uc004crp.2_Silent_p.L620L|NLGN4X_uc004crq.2_Silent_p.L600L|NLGN4X_uc010ndi.2_Silent_p.L637L|NLGN4X_uc004crr.2_Silent_p.L600L|NLGN4X_uc010ndj.2_Silent_p.L600L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	600	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ATCTCGTTCAAGTTGTGCAAA	0.483000													49	38					0	0	0	0
FAM47B	170062	broad.mit.edu	37	X	34961338	34961338	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:34961338C>T	uc004ddi.1	+	1	408	c.390C>T	c.(388-390)CCC>CCT	p.P130P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	130										ovary(3)|breast(1)	4						CCAAGCATCCCTTGGCCATGT	0.557000													40	22					0	0	0	0
COL4A5	1287	broad.mit.edu	37	X	107924156	107924156	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:107924156G>T	uc004enz.1	+	45	4259	c.4057G>T	c.(4057-4059)GAG>TAG	p.E1353*	COL4A5_uc011mso.1_Nonsense_Mutation_p.E1350*|COL4A5_uc011msp.1_Nonsense_Mutation_p.E29*	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1347	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGCTGGCCCTGAGGGGGAACC	0.448000									Alport_syndrome_with_Diffuse_Leiomyomatosis				51	25					1.86277e-20	1.0947e-19	1	0
CT47B1	643311	broad.mit.edu	37	X	120008849	120008850	+	Nonsense_Mutation	DNP	TC	AG	AG			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:120008849_120008850TC>AG	uc011muc.1	-	1	930_931	c.675_676GA>CT	c.(673-678)GAGAAA>GACTAA	p.225_226EK>D*		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	225_226											0						tctgGGGGTTTCTCATCTGCGG	0.559000													6	136					0	0	0	0
MTOR	2475	broad.mit.edu	37	1	11298657	11298657	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:11298657A>G	uc001asd.2	-	12	1925	c.1804T>C	c.(1804-1806)TTT>CTT	p.F602L		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	602					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGGCGAACAAATTGGGTCAGA	0.532													8	5					0	0	0	0
SYTL1	84958	broad.mit.edu	37	1	27677312	27677312	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:27677312G>T	uc001bnw.1	+	11	1200	c.1033G>T	c.(1033-1035)GGC>TGC	p.G345C	SYTL1_uc001bnv.1_Missense_Mutation_p.G333C|SYTL1_uc009vsu.1_Intron|SYTL1_uc001bnx.2_3'UTR|SYTL1_uc009vsv.1_Missense_Mutation_p.G345C	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	345	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGAGCTTCAGGGCCGCGTGCT	0.642													20	24					2.70639e-06	9.62654e-06	1	0
BEND5	79656	broad.mit.edu	37	1	49202034	49202034	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:49202034C>T	uc001crx.3	-	5	1029	c.985G>A	c.(985-987)GCA>ACA	p.A329T	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Missense_Mutation_p.A160T	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	329	BEN.									skin(1)	1						ATCATAACTGCCAAGTTCTTC	0.483													30	144					0	0	0	0
MYSM1	114803	broad.mit.edu	37	1	59131251	59131251	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:59131251T>C	uc009wab.1	-	17	2107	c.2084A>G	c.(2083-2085)TAT>TGT	p.Y695C	MYSM1_uc009waa.1_Missense_Mutation_p.Y101C|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	695					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ATTTCGATTATAGGGACTAAC	0.333													9	67					0	0	0	0
GBP7	388646	broad.mit.edu	37	1	89616146	89616146	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:89616146T>A	uc001dna.2	-	6	877	c.738A>T	c.(736-738)TTA>TTT	p.L246F	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	246						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		CAACATGGAGTAAGAGTTTTT	0.383													22	49					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99772515	99772515	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:99772515T>C	uc001dse.2	+	7	2347	c.2241T>C	c.(2239-2241)ACT>ACC	p.T747T	LPPR4_uc010oue.1_Silent_p.T689T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	747							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCGAAAACACTAGAAATATCT	0.473													23	55					0	0	0	0
SETDB1	9869	broad.mit.edu	37	1	150934615	150934615	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:150934615G>A	uc001evu.2	+	17	3329	c.3139G>A	c.(3139-3141)GAC>AAC	p.D1047N	SETDB1_uc001evv.2_Missense_Mutation_p.D1047N|SETDB1_uc009wmg.1_Missense_Mutation_p.D1047N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1047	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGACACTGACGACCGAAACAA	0.279													73	177					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152187879	152187879	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:152187879T>C	uc001ezt.1	-	3	6302	c.6226A>G	c.(6226-6228)AGG>GGG	p.R2076G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2076	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGACTGCCTTGACCCAGAC	0.627													4	274					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152286148	152286148	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:152286148G>C	uc001ezu.1	-	3	1250	c.1214C>G	c.(1213-1215)GCT>GGT	p.A405G	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	405	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGATGAAGCTTGCCCGCG	0.562									Ichthyosis				140	335					0	0	0	0
DENND1B	163486	broad.mit.edu	37	1	197480968	197480968	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:197480968C>T	uc010ppe.1	-	21	1983	c.1645G>A	c.(1645-1647)GGA>AGA	p.G549R	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						AGAATCTCTCCTAGTAAGTCC	0.418													5	105					0	0	0	0
PFKFB2	5208	broad.mit.edu	37	1	207236550	207236550	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:207236550T>C	uc001hfg.2	+	5	480	c.371T>C	c.(370-372)ATT>ACT	p.I124T	PFKFB2_uc010psc.1_Missense_Mutation_p.I26T|PFKFB2_uc001hfh.2_Missense_Mutation_p.I124T|PFKFB2_uc009xcc.2_Missense_Mutation_p.I82T|PFKFB2_uc010psd.1_5'Flank	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	124	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					AATGGTCAGATTGCGGTAAGC	0.532													9	98					0	0	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212521732	212521732	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:212521732A>T	uc001hjb.2	+	7	1340	c.766A>T	c.(766-768)ATT>TTT	p.I256F	PPP2R5A_uc010ptd.1_Missense_Mutation_p.I197F	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	256					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		TCCCTCCAGTATTATCAATGG	0.368													28	67					0	0	0	0
BPNT1	10380	broad.mit.edu	37	1	220253139	220253139	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:220253139G>C	uc001hma.2	-	2	222	c.50C>G	c.(49-51)TCT>TGT	p.S17C	BPNT1_uc010pug.1_Intron|BPNT1_uc010puh.1_Missense_Mutation_p.S17C|BPNT1_uc001hmb.3_Missense_Mutation_p.S17C	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	17					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		TTGAGCAATAGAATATGCGGA	0.413													8	56					0	0	0	0
WDR64	128025	broad.mit.edu	37	1	241958516	241958516	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:241958516G>C	uc001hzf.1	+	15	1787	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	WDR64_uc001hzg.1_Missense_Mutation_p.R458T	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	992										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAGATTCGAAGATATCCCTTG	0.338													28	117					0	0	0	0
OR2T12	127064	broad.mit.edu	37	1	248458107	248458107	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:248458107C>T	uc010pzj.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTGGGTCTCATATAGGTAA	0.483													50	98					0	0	0	0
OR2T6	254879	broad.mit.edu	37	1	248551197	248551197	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr1:248551197C>A	uc001iei.1	+	1	288	c.288C>A	c.(286-288)GCC>GCA	p.A96A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTCATCGCCTGCACTGCTC	0.532													30	75					3.65163e-15	1.35908e-14	1	0
NMT2	9397	broad.mit.edu	37	10	15151773	15151773	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr10:15151773C>G	uc001inz.1	-	11	1488	c.1404G>C	c.(1402-1404)AAG>AAC	p.K468N	NMT2_uc001ioa.1_Missense_Mutation_p.K455N|NMT2_uc009xjo.1_Intron|NMT2_uc010qbz.1_Missense_Mutation_p.K280N	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	468					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						CTATACCAAACTTGAGTTTTT	0.328													14	91					0	0	0	0
SH2D4B	387694	broad.mit.edu	37	10	82363350	82363350	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr10:82363350C>T	uc001kck.1	+	5	1089	c.659C>T	c.(658-660)GCG>GTG	p.A220V	SH2D4B_uc001kcl.1_Missense_Mutation_p.A171V|SH2D4B_uc001kcm.1_5'UTR	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	219	Glu-rich.										0			Colorectal(32;0.229)			CGGTCCAAGGCGGCTGATGAG	0.642													5	2					0	0	0	0
OR52A4	390053	broad.mit.edu	37	11	5142746	5142746	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:5142746G>A	uc001lzz.1	-	1	63	c.63C>T	c.(61-63)ATC>ATT	p.I21I	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAAACCGGGGATCCCAATAA	0.418													24	119					0	0	0	0
OR5F1	338674	broad.mit.edu	37	11	55761646	55761646	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:55761646C>A	uc010riv.1	-	1	456	c.456G>T	c.(454-456)GGG>GGT	p.G152G		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGTTCAGCAACCCTGCAGCAA	0.507													11	60					9.70103e-10	3.49486e-09	1	0
GLYATL1	92292	broad.mit.edu	37	11	58723492	58723492	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:58723492C>G	uc001nnf.2	+	8	1277	c.901C>G	c.(901-903)CCA>GCA	p.P301A	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.P332A|GLYATL1_uc001nni.1_Missense_Mutation_p.P301A|GLYATL1_uc001nnj.1_Missense_Mutation_p.P301A			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	301						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GAATCTAGTTCCATTTTAGAC	0.388													3	86					0	0	0	0
POLR2G	5436	broad.mit.edu	37	11	62532822	62532822	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:62532822C>T	uc001nva.2	+	5	454	c.344C>T	c.(343-345)TCA>TTA	p.S115L	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	115					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						TCCATCCCTTCAGAGATGGAG	0.458													28	288					0	0	0	0
NXF1	10482	broad.mit.edu	37	11	62569082	62569082	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:62569082C>T	uc001nvf.1	-	7	797	c.661G>A	c.(661-663)GAT>AAT	p.D221N	NXF1_uc001nvg.1_Missense_Mutation_p.D221N|NXF1_uc009yog.1_Missense_Mutation_p.D264N|NXF1_uc010rmh.1_Missense_Mutation_p.D84N	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	221	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGGGAGCCATCGTATCGTTTG	0.507													18	170					0	0	0	0
EHD1	10938	broad.mit.edu	37	11	64627443	64627443	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:64627443C>A	uc001obu.1	-	3	1123	c.868G>T	c.(868-870)GCC>TCC	p.A290S	EHD1_uc001obv.1_Missense_Mutation_p.A290S|EHD1_uc010rnq.1_Missense_Mutation_p.A304S	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	290					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						TTCCTGAGGGCGGCGTTTCGG	0.637													46	32					3.21987e-24	1.231e-23	1	0
ALKBH8	91801	broad.mit.edu	37	11	107431547	107431547	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:107431547C>T	uc010rvr.1	-	2	148	c.73G>A	c.(73-75)GCC>ACC	p.A25T	ALKBH8_uc009yxp.2_Missense_Mutation_p.A25T|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	25					response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		GTATGCTTGGCTTTAATCTGT	0.348													13	29					0	0	0	0
OR4D5	219875	broad.mit.edu	37	11	123811175	123811175	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr11:123811175T>C	uc001pzk.1	+	1	852	c.852T>C	c.(850-852)CCT>CCC	p.P284P		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGCTGAATCCTGCCATCTATA	0.502													22	86					0	0	0	0
C3AR1	719	broad.mit.edu	37	12	8211391	8211391	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:8211391C>T	uc001qtv.1	-	2	1483	c.1391G>A	c.(1390-1392)CGT>CAT	p.R464H		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	464	Cytoplasmic (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		GTGGGTGGAACGTGTGAGCTC	0.473													34	91					0	0	0	0
PHC1	1911	broad.mit.edu	37	12	9092018	9092018	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:9092018A>T	uc001qvd.2	+	15	3134	c.2978A>T	c.(2977-2979)AAG>ATG	p.K993M	PHC1_uc001qve.2_Missense_Mutation_p.K993M	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	993	SAM.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CCTGCCCTCAAGATCTGCGCC	0.488													13	14					0	0	0	0
PZP	5858	broad.mit.edu	37	12	9353588	9353588	+	Silent	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:9353588G>C	uc001qvl.2	-	6	599	c.570C>G	c.(568-570)TCC>TCG	p.S190S	PZP_uc009zgl.2_Silent_p.S59S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGAGGGGAAAGGACAACTGAT	0.498													27	130					0	0	0	0
PRB4	5545	broad.mit.edu	37	12	11461798	11461798	+	Missense_Mutation	SNP	C	T	T	rs77336955		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:11461798C>T	uc001qzf.1	-	3	153	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PRB4_uc001qzt.2_Missense_Mutation_p.R40H	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	40	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|1.					extracellular region				ovary(1)	1						TCCTTGTGGGCGTCGTCCTTC	0.552										HNSCC(22;0.051)			33	444					0	0	0	0
DNM1L	10059	broad.mit.edu	37	12	32886735	32886735	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:32886735T>C	uc001rld.2	+	13	1694	c.1533T>C	c.(1531-1533)AAT>AAC	p.N511N	DNM1L_uc001rle.2_Silent_p.N511N|DNM1L_uc001rlf.2_Silent_p.N511N|DNM1L_uc010skh.1_Silent_p.N577N|DNM1L_uc001rlg.2_Silent_p.N577N|DNM1L_uc001rlh.2_Silent_p.N564N|DNM1L_uc010ski.1_Silent_p.N308N	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	511	Interaction with GSK3B.|B domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGAACAATAATATAGAGGTAA	0.303													53	148					0	0	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46315837	46315837	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:46315837T>C	uc001rox.2	-	15	4673	c.4386A>G	c.(4384-4386)ATA>ATG	p.I1462M	SFRS2IP_uc001row.2_Missense_Mutation_p.I1147M	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1462					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTTCAGCCTATGTTTTTTT	0.378													3	148					0	0	0	0
OR6C1	390321	broad.mit.edu	37	12	55714812	55714812	+	Silent	SNP	T	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:55714812T>G	uc010spi.1	+	1	429	c.429T>G	c.(427-429)GTT>GTG	p.V143V		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						CACTGCTTGTTTTTACTTCTT	0.408													6	22					0	0	0	0
COQ10A	93058	broad.mit.edu	37	12	56663287	56663287	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:56663287T>C	uc001sko.3	+	4	779	c.518T>C	c.(517-519)ATT>ACT	p.I173T	COQ10A_uc001skp.3_Missense_Mutation_p.I141T|COQ10A_uc001skq.3_Missense_Mutation_p.I156T	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	173						mitochondrial inner membrane				ovary(1)	1						TTAGAGACTATTTGGCGATTC	0.438													22	143					0	0	0	0
LEMD3	23592	broad.mit.edu	37	12	65564805	65564805	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:65564805C>G	uc001ssl.1	+	1	1435	c.1429C>G	c.(1429-1431)CTC>GTC	p.L477V	LEMD3_uc009zqo.1_Missense_Mutation_p.L477V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	477	Helical; (Potential).				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTCGATGTTTCTCTTAACTGC	0.478													23	38					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81777935	81777935	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:81777935A>T	uc001szo.1	-	9	1012	c.851T>A	c.(850-852)ATG>AAG	p.M284K	PPFIA2_uc010sue.1_Missense_Mutation_p.M184K|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	210										ovary(3)|lung(2)|pancreas(1)	6						CATCTGGGCCATTTCATAGTT	0.413													10	25					0	0	0	0
TMTC3	160418	broad.mit.edu	37	12	88589416	88589416	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:88589416A>G	uc001tau.2	+	14	2955	c.2735A>G	c.(2734-2736)AAT>AGT	p.N912S		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	913						integral to membrane	binding			skin(1)	1						CGTATTTTAAATGGTGAATAA	0.333													12	50					0	0	0	0
TXNRD1	7296	broad.mit.edu	37	12	104732985	104732985	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:104732985G>A	uc010swk.1	+	16	1837	c.1815G>A	c.(1813-1815)GCG>GCA	p.A605A	TXNRD1_uc010swl.1_Silent_p.A455A|TXNRD1_uc010swm.1_Silent_p.A507A|TXNRD1_uc010swn.1_Silent_p.A455A|TXNRD1_uc010swo.1_Silent_p.A455A|TXNRD1_uc010swp.1_Silent_p.A417A|TXNRD1_uc010swq.1_Silent_p.A505A|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Silent_p.A521A	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	605					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TTGCAGCTGCGCTCAAATGTG	0.433													9	29					0	0	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958362	122958362	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:122958362C>A	uc001ucn.2	-	14	1937	c.1806G>T	c.(1804-1806)GAG>GAT	p.E602D	ZCCHC8_uc001ucl.2_Missense_Mutation_p.E213D|ZCCHC8_uc001ucm.2_Missense_Mutation_p.E364D|ZCCHC8_uc009zxp.2_Missense_Mutation_p.E364D|ZCCHC8_uc009zxq.2_Missense_Mutation_p.E364D	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	602						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GTGATGTCACCTCAGAGTCTG	0.463													7	250					0.00198382	0.00679821	1	0
LOC284232	284232	broad.mit.edu	37	13	19415849	19415849	+	RNA	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:19415849T>A	uc010tcj.1	-	1		c.30261A>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						ATTTCCTTCTTTGACCtttaa	0.249													4	19					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23910945	23910945	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:23910945T>A	uc001uon.2	-	10	7659	c.7070A>T	c.(7069-7071)GAA>GTA	p.E2357V	SACS_uc001uoo.2_Missense_Mutation_p.E2210V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2357					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGAAACCTTTTCTGAGTCAAC	0.333													25	50					0	0	0	0
FOXO1	2308	broad.mit.edu	37	13	41134865	41134865	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:41134865C>T	uc001uxl.3	-	2	1148	c.763G>A	c.(763-765)GCA>ACA	p.A255T	FOXO1_uc010acc.1_Missense_Mutation_p.A70T	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	255					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TCCATGGATGCAGCTCTTCTC	0.517													18	149					0	0	0	0
TSC22D1	8848	broad.mit.edu	37	13	45148997	45148997	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:45148997G>A	uc001uzn.3	-	1	1705	c.1214C>T	c.(1213-1215)TCG>TTG	p.S405L	TSC22D1_uc001uzo.1_Missense_Mutation_p.S405L	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	405					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCTGAACCTCGAAGTGTTAAC	0.438													25	83					0	0	0	0
OLFM4	10562	broad.mit.edu	37	13	53608558	53608558	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:53608558T>A	uc001vhl.2	+	2	280	c.280T>A	c.(280-282)TTT>ATT	p.F94I	OLFM4_uc001vhk.1_Missense_Mutation_p.F94I	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	94					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		AGACACCACCTTTCCCGTGGA	0.443													10	84					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60413536	60413536	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:60413536C>A	uc001vht.2	-	23	3003	c.2784G>T	c.(2782-2784)CAG>CAT	p.Q928H	DIAPH3_uc001vhu.2_Missense_Mutation_p.Q665H	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	928	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GCTGTTGAAGCTGCCTTCCCA	0.383													16	38					1.15088e-07	4.1197e-07	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455394	84455394	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:84455394A>T	uc001vlk.2	-	1	1135	c.249T>A	c.(247-249)AAT>AAA	p.N83K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	83	Extracellular (Potential).|LRR 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AACTAACCGCATTATAAAAGT	0.463													31	65					0	0	0	0
COL4A2	1284	broad.mit.edu	37	13	111102707	111102707	+	Silent	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr13:111102707C>G	uc001vqx.2	+	20	1534	c.1245C>G	c.(1243-1245)CCC>CCG	p.P415P		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	415	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCGGAGACCCCGGCATCCCTG	0.637													3	81					0	0	0	0
NID2	22795	broad.mit.edu	37	14	52520462	52520462	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr14:52520462G>T	uc001wzo.2	-	5	1498	c.1264C>A	c.(1264-1266)CCC>ACC	p.P422T	NID2_uc010tqs.1_Missense_Mutation_p.P422T|NID2_uc010tqt.1_Missense_Mutation_p.P422T|NID2_uc001wzp.2_Missense_Mutation_p.P422T	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	422						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TCTGGGTAGGGCTGGATGCTT	0.552													23	59					1.10513e-12	4.05938e-12	1	0
SYNE2	23224	broad.mit.edu	37	14	64468762	64468762	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr14:64468762A>T	uc001xgm.2	+	29	3979	c.3749A>T	c.(3748-3750)CAT>CTT	p.H1250L	SYNE2_uc001xgl.2_Missense_Mutation_p.H1250L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1250	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGGATTTCATCTCATTGAT	0.418													33	81					0	0	0	0
C14orf179	112752	broad.mit.edu	37	14	76549919	76549919	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr14:76549919G>C	uc010asm.1	+	9	660	c.626G>C	c.(625-627)TGA>TCA	p.*209S	C14orf179_uc001xsg.2_Nonstop_Mutation_p.*214S|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	209					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		AGGCACACCTGAGCCCGTCAC	0.507													6	57					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88945598	88945598	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr14:88945598C>G	uc001xwv.3	-	13	2508	c.2177G>C	c.(2176-2178)CGG>CCG	p.R726P	PTPN21_uc010twc.1_Missense_Mutation_p.R522P	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	726						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						AGGAGGCGCCCGGGCCCCGCT	0.701													3	20					0	0	0	0
Unknown	0	broad.mit.edu	37	15	20649492	20649492	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:20649492C>G	uc001ytg.2	-	18	2726	c.2017G>C	c.(2017-2019)GAG>CAG	p.E673Q	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.E673Q|uc010tyy.1_Missense_Mutation_p.E673Q					RecName: Full=Putative HERC2-like protein 3;																		GAGTCGTCCTCTGTGTCCGAA	0.562													38	137					0	0	0	0
Unknown	0	broad.mit.edu	37	15	22473131	22473131	+	RNA	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:22473131G>T	uc001yuj.1	-	2		c.140C>A								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		ACTGCTGATGGAGCCACCAGA	0.612													29	153					3.73988e-18	1.41061e-17	1	0
MAGEL2	54551	broad.mit.edu	37	15	23889583	23889583	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:23889583A>G	uc001ywj.3	-	1	1593	c.1498T>C	c.(1498-1500)TCC>CCC	p.S500P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TCTAAATAGGATGCCACCAAA	0.423													5	40					0	0	0	0
NDN	4692	broad.mit.edu	37	15	23931584	23931584	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:23931584A>G	uc001ywk.2	-	1	867	c.781T>C	c.(781-783)TTT>CTT	p.F261L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	261	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GAGCCCCAAAAGAACTCGTAT	0.572									Prader-Willi_syndrome				5	56					0	0	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938448	30938448	+	RNA	SNP	A	G	G	rs146574312	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:30938448A>G	uc010azv.1	+	11		c.1258A>G			ARHGAP11B_uc001zeu.2_RNA			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CTATTTGTGCATGGTGGCTGG	0.483													4	43					0	0	0	0
PYGO1	26108	broad.mit.edu	37	15	55838317	55838317	+	Silent	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:55838317T>A	uc010bfl.1	-	3	1220	c.1164A>T	c.(1162-1164)GCA>GCT	p.A388A	PYGO1_uc002adf.1_Silent_p.A388A	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	388	PHD-type.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGCCCCATACTGCAGATGCTT	0.448													25	60					0	0	0	0
LRRC28	123355	broad.mit.edu	37	15	99901641	99901641	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr15:99901641G>A	uc002bva.1	+	8	951	c.796G>A	c.(796-798)GAG>AAG	p.E266K	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.E112K|LRRC28_uc010urt.1_Missense_Mutation_p.E80K|LRRC28_uc002bvc.1_Missense_Mutation_p.E266K|LRRC28_uc010uru.1_Missense_Mutation_p.E197K|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	266											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CATAGGGACGGAGCATGATCA	0.522											OREG0023509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	63					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18875116	18875116	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr16:18875116T>C	uc002dfm.2	-	25	3914	c.3551A>G	c.(3550-3552)AAT>AGT	p.N1184S	SMG1_uc010bwb.2_Missense_Mutation_p.N1044S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1184	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TCCTAAATAATTTATAACCTC	0.403													13	36					0	0	0	0
CHST4	10164	broad.mit.edu	37	16	71570812	71570812	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr16:71570812G>A	uc002fan.2	+	2	413	c.232G>A	c.(232-234)GTG>ATG	p.V78M	CHST4_uc002fao.2_Missense_Mutation_p.V78M	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	78	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						CGCCTGGCACGTGTGGATGAC	0.577													30	62					0	0	0	0
OR1A2	26189	broad.mit.edu	37	17	3101177	3101177	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:3101177G>A	uc002fvd.1	+	1	365	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCATACGATCGAGCTGTGGCC	0.483													32	60					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	21					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7752094	7752094	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:7752094G>A	uc002giw.1	+	11	2864	c.2488G>A	c.(2488-2490)GGG>AGG	p.G830R	KDM6B_uc002gix.2_Missense_Mutation_p.G132R	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	830	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CACCCGGCCTGGGCCCTTGCC	0.657													9	131					0	0	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904193	21904193	+	RNA	SNP	C	G	G	rs9904221	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:21904193C>G	uc002gza.2	+	1		c.132C>G				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						cagcctcaggcctgccaggac	0													6	112					0	0	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904197	21904197	+	RNA	SNP	C	T	T	rs9904223	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:21904197C>T	uc002gza.2	+	1		c.136C>T				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						ctcaggcctgccaggacggtg	0													6	109					0	0	0	0
ICAM2	3384	broad.mit.edu	37	17	62081229	62081229	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr17:62081229G>T	uc002jdu.3	-	3	656	c.424C>A	c.(424-426)CTG>ATG	p.L142M	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.L142M|ICAM2_uc010ded.2_Missense_Mutation_p.L142M|ICAM2_uc002jdx.3_Missense_Mutation_p.L142M|ICAM2_uc002jdv.3_Missense_Mutation_p.L142M	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	142	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						AGGCTGTCCAGGGGCTCCACG	0.607													7	45					0.000157383	0.000542634	1	0
MAPK4	5596	broad.mit.edu	37	18	48252451	48252451	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr18:48252451C>T	uc002lev.2	+	5	1973	c.973C>T	c.(973-975)CAA>TAA	p.Q325*	MAPK4_uc010xdm.1_Nonsense_Mutation_p.Q114*|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	325					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GCCCACCTCACAACACCCCTT	0.582													36	31					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64172067	64172067	+	Silent	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr18:64172067T>A	uc002lkc.1	-	12	2439	c.2301A>T	c.(2299-2301)GCA>GCT	p.A767A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	767	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTGACTGCACTGCAGAACCAA	0.368													18	19					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8191467	8191467	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:8191467C>T	uc002mjf.2	-	19	2460	c.2439G>A	c.(2437-2439)TGG>TGA	p.W813*		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	813	TB 4.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGATCTTCAGCCAGCAGGTGC	0.677													6	12					0	0	0	0
OR10H2	26538	broad.mit.edu	37	19	15839701	15839701	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:15839701C>T	uc002nbm.2	+	1	868	c.848C>T	c.(847-849)ACG>ATG	p.T283M		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCAGTCCTCACGCCCTTCCTC	0.547													29	119					0	0	0	0
MEF2B	100271849	broad.mit.edu	37	19	19260222	19260222	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:19260222C>G	uc002nlm.2	-	3	185	c.71G>C	c.(70-72)CGG>CCG	p.R24P	MEF2B_uc002nln.2_Missense_Mutation_p.R71P|MEF2B_uc002nll.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R24P|MEF2B_uc002nlk.2_Missense_Mutation_p.R24P	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			CCCGAACTTCCGCTTGGTGAA	0.562													16	54					0	0	0	0
ZNF43	7594	broad.mit.edu	37	19	21990434	21990434	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:21990434G>A	uc002nqj.2	-	4	2535	c.2405C>T	c.(2404-2406)CCT>CTT	p.P802L	ZNF43_uc010ecv.2_Missense_Mutation_p.P796L|ZNF43_uc002nql.2_Missense_Mutation_p.P796L|ZNF43_uc002nqm.2_Missense_Mutation_p.P796L|ZNF43_uc002nqk.2_Missense_Mutation_p.P732L	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AAAAGTTTGAGGTGTTGTCAA	0.313													9	43					0	0	0	0
NR1H2	7376	broad.mit.edu	37	19	50881485	50881485	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:50881485C>T	uc010enw.2	+	5	537	c.261C>T	c.(259-261)TGC>TGT	p.C87C	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Silent_p.C87C|NR1H2_uc002psa.3_Intron	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	87	Nuclear receptor.|NR C4-type.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		ACGAGCTTTGCCGTGTCTGTG	0.637													5	161					0	0	0	0
CEACAM18	729767	broad.mit.edu	37	19	51984689	51984689	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr19:51984689T>C	uc002pwv.1	+	4	626	c.626T>C	c.(625-627)CTG>CCG	p.L209P		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	209						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCCAGCTCCCTGGTGGAGAAC	0.507													27	23					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415923	15415923	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:15415923C>T	uc002rcc.1	-	44	5435	c.5409G>A	c.(5407-5409)CTG>CTA	p.L1803L	NBAS_uc010exl.1_Silent_p.L875L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1803										ovary(2)|liver(1)|skin(1)	4						TTTCATCTGTCAGCTTTTTGT	0.363													6	93					0	0	0	0
AGBL5	60509	broad.mit.edu	37	2	27278036	27278036	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:27278036C>T	uc002rie.2	+	6	1040	c.823C>T	c.(823-825)CCC>TCC	p.P275S	AGBL5_uc002ric.2_Missense_Mutation_p.P275S|AGBL5_uc002rid.2_Missense_Mutation_p.P275S|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	275					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTGATGATCCCCGGGCCCA	0.537													29	189					0	0	0	0
Unknown	0	broad.mit.edu	37	2	96593025	96593025	+	RNA	SNP	C	T	T	rs75189823	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:96593025C>T	uc002sva.1	-	9		c.380G>A			uc010yug.1_RNA|uc002svc.1_RNA					Homo sapiens cDNA FLJ41632 fis, clone FCBBF1000297, highly  similar to Human protein immuno-reactive with anti-PTH polyclonal antibodies mRNA.																		TCTTTCTCATCACTTGTAGCC	0.318													10	107					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116510763	116510763	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:116510763A>C	uc002tla.1	+	11	1421	c.964A>C	c.(964-966)ACT>CCT	p.T322P	DPP10_uc002tlb.1_Missense_Mutation_p.T272P|DPP10_uc002tlc.1_Missense_Mutation_p.T318P|DPP10_uc002tle.2_Missense_Mutation_p.T326P|DPP10_uc002tlf.1_Missense_Mutation_p.T315P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	322	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACTATATCACTATGGTTAA	0.358													5	34					0	0	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111147	136111147	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:136111147C>G	uc002tum.2	-	4	349	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.E78Q|ZRANB3_uc002tun.1_Missense_Mutation_p.E18Q	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	78	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GGCCATTCCTCTTTATAGAAG	0.318													3	44					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141299370	141299370	+	Silent	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:141299370A>T	uc002tvj.1	-	44	8337	c.7365T>A	c.(7363-7365)GCT>GCA	p.A2455A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2455	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTGGCAACAGCTATGATTC	0.363										TSP Lung(27;0.18)			9	137					0	0	0	0
KCNH7	90134	broad.mit.edu	37	2	163228467	163228467	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:163228467G>T	uc002uch.1	-	16	3675	c.3463C>A	c.(3463-3465)CAC>AAC	p.H1155N		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1155	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGCCGCAGGTGAAGCTCTAAA	0.428													8	47					1.12685e-05	3.93348e-05	1	0
SCN1A	6323	broad.mit.edu	37	2	166901572	166901572	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:166901572C>G	uc010zcz.1	-	10	1661	c.1643G>C	c.(1642-1644)AGG>ACG	p.R548T	SCN1A_uc002udo.3_Missense_Mutation_p.R417T|SCN1A_uc010fpk.2_Missense_Mutation_p.R417T	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	548						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGAGGAGTACCTCTTTTCATA	0.433													44	82					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9364994	9364994	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:9364994G>A	uc002wnf.2	+	13	1136	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	PLCB4_uc010gbw.1_Missense_Mutation_p.G334S|PLCB4_uc010gbx.2_Missense_Mutation_p.G334S|PLCB4_uc002wne.2_Missense_Mutation_p.G334S|PLCB4_uc002wnh.2_Missense_Mutation_p.G181S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	334	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTATCTCACTGGCAGACAGTT	0.463													35	71					0	0	0	0
PLK1S1	55857	broad.mit.edu	37	20	21143094	21143094	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:21143094G>A	uc002wsb.2	+	5	1121	c.988G>A	c.(988-990)GAA>AAA	p.E330K	PLK1S1_uc010zsh.1_Missense_Mutation_p.E227K|PLK1S1_uc010zsi.1_Missense_Mutation_p.E197K|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	330					spindle organization	centrosome	protein kinase binding				0						AGAATACTGTGAATCTGAAAA	0.468													8	20					0	0	0	0
NKX2-4	644524	broad.mit.edu	37	20	21377938	21377938	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:21377938C>T	uc010gcz.2	-	1	110	c.100G>A	c.(100-102)GCG>ACG	p.A34T		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	34					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccgggtggcgcgccgTCCATG	0.517													4	7					0	0	0	0
NINL	22981	broad.mit.edu	37	20	25459583	25459583	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:25459583T>C	uc002wux.1	-	16	2251	c.2177A>G	c.(2176-2178)CAT>CGT	p.H726R	NINL_uc010gdn.1_Missense_Mutation_p.H726R|NINL_uc010gdo.1_Missense_Mutation_p.H509R	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	726					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTGGCTGTGATGCCGCAGGGC	0.582													33	73					0	0	0	0
GSS	2937	broad.mit.edu	37	20	33524591	33524591	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:33524591G>A	uc002xbg.2	-	8	822	c.742C>T	c.(742-744)CTG>TTG	p.L248L	GSS_uc010zun.1_Silent_p.L120L|GSS_uc010zuo.1_Silent_p.L137L|GSS_uc010zup.1_Silent_p.L179L|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	248					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TCTTGGTCCAGAGACCCCTTT	0.473													43	226					0	0	0	0
EEF1A2	1917	broad.mit.edu	37	20	62122079	62122079	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr20:62122079G>A	uc002yfd.1	-	5	883	c.782C>T	c.(781-783)ACG>ATG	p.T261M	EEF1A2_uc002yfe.1_Missense_Mutation_p.T261M|EEF1A2_uc010gkg.1_Missense_Mutation_p.T261M	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	261						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CACGGGCACCGTGCCAATGCC	0.647													18	41					0	0	0	0
Unknown	0	broad.mit.edu	37	21	10862909	10862909	+	IGR	SNP	T	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr21:10862909T>G								None (None upstream) : TPTE (43834 downstream)																							GTGGATGGGATTGGTGTGCCC	0.542													11	239					0	0	0	0
Unknown	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr22:18844763T>C	uc002zoe.2	+	4		c.2017T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TCACAGCCTCTGAGGGCAGCA	0.562													5	7					0	0	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20127041	20127041	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr22:20127041G>A	uc002zrq.2	+	3	373	c.267G>A	c.(265-267)CCG>CCA	p.P89P	ZDHHC8_uc002zrr.1_Silent_p.P89P|ZDHHC8_uc010gsa.2_5'UTR	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	89	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TCCGGGCTCCGCTGTACAAGA	0.607													61	44					0	0	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33885692	33885692	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr3:33885692A>C	uc003cfx.2	+	11	1603	c.1448A>C	c.(1447-1449)GAA>GCA	p.E483A	PDCD6IP_uc003cfy.2_Missense_Mutation_p.E488A|PDCD6IP_uc011axw.1_Missense_Mutation_p.E264A	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	483	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						CCATCCAATGAACTGTATAAG	0.343													4	63					0	0	0	0
WDR53	348793	broad.mit.edu	37	3	196281606	196281606	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr3:196281606T>C	uc003fwt.2	-	4	1024	c.553A>G	c.(553-555)ATG>GTG	p.M185V		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	185										breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGGCCTTCCATTTCTTCTGTT	0.438													80	288					0	0	0	0
CNGA1	1259	broad.mit.edu	37	4	47939078	47939078	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:47939078C>T	uc003gxt.3	-	11	1699	c.1433G>A	c.(1432-1434)CGC>CAC	p.R478H	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.R547H	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	478	Extracellular (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						AGCAAAAATGCGTACCTTTTT	0.378													22	92					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956863	73956863	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:73956863T>A	uc003hgp.2	-	29	6599	c.6482A>T	c.(6481-6483)CAG>CTG	p.Q2161L	ANKRD17_uc003hgo.2_Missense_Mutation_p.Q2048L|ANKRD17_uc003hgq.2_Missense_Mutation_p.Q1910L|ANKRD17_uc003hgr.2_Missense_Mutation_p.Q2160L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2161					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTGGTGTCTGAGGCATAGG	0.532													39	170					0	0	0	0
DMP1	1758	broad.mit.edu	37	4	88584472	88584472	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:88584472G>C	uc003hqv.2	+	6	1646	c.1542G>C	c.(1540-1542)TAG>TAC	p.*514Y	DMP1_uc003hqw.2_Nonstop_Mutation_p.*498Y	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	514					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		ACGGCTATTAGCATCAGCTGT	0.373													32	134					0	0	0	0
PDHA2	5161	broad.mit.edu	37	4	96761919	96761919	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:96761919C>T	uc003htr.3	+	1	681	c.618C>T	c.(616-618)TTC>TTT	p.F206F		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	206					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCGAAGCTTTCAATATGGCAG	0.443													14	49					0	0	0	0
C4orf31	79625	broad.mit.edu	37	4	121958183	121958183	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:121958183A>T	uc003idq.1	-	4	1470	c.943T>A	c.(943-945)TTT>ATT	p.F315I		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	315	Fibronectin type-III 1.										0						TTGACCACAAATACATCAAAG	0.453													15	71					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79027402	79027402	+	Silent	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr5:79027402T>C	uc003kgc.2	+	2	2886	c.2814T>C	c.(2812-2814)GAT>GAC	p.D938D		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	938						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGAAGAAGATCAAGAAGACA	0.413													48	39					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90041015	90041015	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr5:90041015C>G	uc003kju.2	+	51	10798	c.10702C>G	c.(10702-10704)CTA>GTA	p.L3568V	GPR98_uc003kjt.2_Missense_Mutation_p.L1274V|GPR98_uc003kjv.2_Missense_Mutation_p.L1168V	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3568	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTAATAGCTCTAGTGGGAGC	0.368													40	134					0	0	0	0
CYFIP2	26999	broad.mit.edu	37	5	156741393	156741393	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr5:156741393G>A	uc003lwq.2	+	14	1290	c.1152G>A	c.(1150-1152)GAG>GAA	p.E384E	CYFIP2_uc011ddn.1_Silent_p.E358E|CYFIP2_uc011ddo.1_Silent_p.E188E|CYFIP2_uc003lwr.2_Silent_p.E384E|CYFIP2_uc003lws.2_Silent_p.E384E|CYFIP2_uc003lwt.2_Silent_p.E262E|CYFIP2_uc011ddp.1_Silent_p.E118E	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	384					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTCAGACGAGGAGTATCGCG	0.517													22	35					0	0	0	0
FGFR4	2264	broad.mit.edu	37	5	176519733	176519733	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr5:176519733A>G	uc003mfl.2	+	8	1172	c.1005A>G	c.(1003-1005)GCA>GCG	p.A335A	FGFR4_uc003mfm.2_Silent_p.A335A|FGFR4_uc011dfu.1_Silent_p.A335A|FGFR4_uc011dfw.1_Silent_p.A335A|FGFR4_uc003mfo.2_Silent_p.A335A	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	335	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTGCCTCGCAGGCAATTCCA	0.637										TSP Lung(9;0.080)			23	31					0	0	0	0
PRPF4B	8899	broad.mit.edu	37	6	4037761	4037761	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:4037761C>T	uc003mvv.2	+	3	1460	c.1369C>T	c.(1369-1371)CGT>TGT	p.R457C	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	457	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CCCACTCAGACGTAGCAGGTC	0.448													20	41					0	0	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26205025	26205025	+	Silent	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:26205025C>A	uc003ngy.2	+	1	153	c.153C>A	c.(151-153)ATC>ATA	p.I51I		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				CTGGTCTCATCTACGAGGAGA	0.562													38	68					6.99958e-10	2.53791e-09	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27834842	27834842	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:27834842G>C	uc003njx.2	-	1	518	c.466C>G	c.(466-468)CCG>GCG	p.P156A		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	156					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						GCCTTCTTCGGAGTCTTCTTC	0.602													5	231					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283873	33283873	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:33283873G>A	uc003oeb.2	-	2	973	c.821C>T	c.(820-822)GCA>GTA	p.A274V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.A274V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGAACCACTGCCCCCCTCCC	0.607													12	45					0	0	0	0
BYSL	705	broad.mit.edu	37	6	41889501	41889501	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:41889501G>C	uc003orl.2	+	1	537	c.201G>C	c.(199-201)GAG>GAC	p.E67D	MED20_uc003orj.2_5'Flank|MED20_uc003ork.2_5'Flank|MED20_uc011duh.1_5'Flank|MED20_uc011dui.1_5'Flank|MED20_uc011duj.1_5'Flank	NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	67					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCAACAGGAGGAACTCGAGG	0.677											OREG0017436	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	26					0	0	0	0
PRIM2	5558	broad.mit.edu	37	6	57512691	57512691	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:57512691G>A	uc003pdx.2	+	15	1606	c.1519G>A	c.(1519-1521)GAA>AAA	p.E507K		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	507					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTACTTTAGTGAAGATTCTTA	0.333													16	473					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83849755	83849755	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:83849755G>A	uc003pjs.1	+	22	5417	c.5157G>A	c.(5155-5157)ATG>ATA	p.M1719I	DOPEY1_uc011dyy.1_Missense_Mutation_p.M1710I|DOPEY1_uc010kbl.1_Missense_Mutation_p.M1710I|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1719					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CACCAGATATGATTCTTACTC	0.338													9	41					0	0	0	0
PGM3	5238	broad.mit.edu	37	6	83896760	83896760	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:83896760C>T	uc003pjv.2	-	4	464	c.424G>A	c.(424-426)GAT>AAT	p.D142N	PGM3_uc003pjw.2_Missense_Mutation_p.D61N|PGM3_uc011dyz.1_Missense_Mutation_p.D170N	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	142					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		GTCACACCATCTATTACAGAT	0.328													20	61					0	0	0	0
RRAGD	58528	broad.mit.edu	37	6	90097155	90097155	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:90097155G>T	uc003pnd.3	-	2	586	c.303C>A	c.(301-303)TGC>TGA	p.C101*	RRAGD_uc010kcc.2_Intron	NM_021244	NP_067067	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	101					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			ovary(2)|central_nervous_system(1)	3		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CATCTTCCCGGCATATCTTAT	0.428													98	190					5.01286e-43	1.92961e-42	1	0
WASF1	8936	broad.mit.edu	37	6	110421867	110421867	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:110421867T>C	uc003ptv.1	-	11	2375	c.1538A>G	c.(1537-1539)AAA>AGA	p.K513R	WASF1_uc003ptw.1_Missense_Mutation_p.K513R|WASF1_uc003ptx.1_Missense_Mutation_p.K513R|WASF1_uc003pty.1_Missense_Mutation_p.K513R	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	513	WH2.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CTCTTCTACTTTGCGTAGCTG	0.363													14	27					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117724426	117724426	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:117724426C>T	uc003pxp.1	-	6	652	c.453G>A	c.(451-453)CCG>CCA	p.P151P	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	151	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCACATAGGACGGTCTGGACA	0.473			T	GOPC|ROS1	glioblastoma|NSCLC								11	26					0	0	0	0
PTPRK	5796	broad.mit.edu	37	6	128404886	128404886	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:128404886G>C	uc003qbk.2	-	9	1916	c.1549C>G	c.(1549-1551)CCA>GCA	p.P517A	PTPRK_uc003qbj.2_Missense_Mutation_p.P517A|PTPRK_uc010kfc.2_Missense_Mutation_p.P517A|PTPRK_uc011ebu.1_Missense_Mutation_p.P517A|PTPRK_uc003qbl.1_Missense_Mutation_p.P387A|PTPRK_uc011ebv.1_Missense_Mutation_p.P517A	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	517	Extracellular (Potential).|Fibronectin type-III 3.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTCCATTTGGATCCAAAGGT	0.368													23	99					0	0	0	0
REPS1	85021	broad.mit.edu	37	6	139266690	139266690	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr6:139266690T>C	uc003qii.2	-	3	1001	c.422A>G	c.(421-423)AAG>AGG	p.K141R	REPS1_uc003qig.3_Missense_Mutation_p.K141R|REPS1_uc011edr.1_Missense_Mutation_p.K141R|REPS1_uc003qij.2_Missense_Mutation_p.K141R|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	141						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TACGGATCCCTTTTTCACTTG	0.478													3	138					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11675953	11675953	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:11675953T>A	uc003ssf.3	-	2	1078	c.826A>T	c.(826-828)AGA>TGA	p.R276*		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	276	Extracellular (Potential).|Potential.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTCCCGCGTCTCCTTGCTTGT	0.537										HNSCC(18;0.044)			32	95					0	0	0	0
STK31	56164	broad.mit.edu	37	7	23825129	23825129	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:23825129A>G	uc003sws.3	+	18	2248	c.2181A>G	c.(2179-2181)GAA>GAG	p.E727E	STK31_uc003swt.3_Silent_p.E704E|STK31_uc011jze.1_Silent_p.E727E|STK31_uc010kuq.2_Silent_p.E704E|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	727	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TGAGCTTGGAACGAGATCTTC	0.403													35	90					0	0	0	0
NPC1L1	29881	broad.mit.edu	37	7	44556434	44556434	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:44556434G>A	uc003tlb.2	-	17	3524	c.3468C>T	c.(3466-3468)CTC>CTT	p.L1156L	NPC1L1_uc003tlc.2_Silent_p.L1129L|NPC1L1_uc011kbw.1_Silent_p.L1083L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1156	Helical; Name=10; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GGCCCAGCAGGAGGCAGGAGA	0.592													14	42					0	0	0	0
EGFR	1956	broad.mit.edu	37	7	55210124	55210124	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:55210124C>G	uc003tqk.2	+	2	480	c.234C>G	c.(232-234)TTC>TTG	p.F78L	EGFR_uc003tqh.2_Missense_Mutation_p.F78L|EGFR_uc003tqi.2_Missense_Mutation_p.F78L|EGFR_uc003tqj.2_Missense_Mutation_p.F78L|EGFR_uc010kzg.1_Missense_Mutation_p.F78L|EGFR_uc011kco.1_Missense_Mutation_p.F25L	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	78	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATCTTTCCTTCTTAAAGGTTG	0.378		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	862					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57188238	57188238	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:57188238C>G	uc010kzo.2	-	5	1155	c.884G>C	c.(883-885)AGA>ACA	p.R295T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTTGTAGGGTCTCTCTCCAGT	0.473													6	70					0	0	0	0
POM121	9883	broad.mit.edu	37	7	72413634	72413634	+	Silent	SNP	G	A	A	rs139238552	byFrequency	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:72413634G>A	uc003twk.2	+	11	3102	c.3102G>A	c.(3100-3102)ACG>ACA	p.T1034T	POM121_uc003twj.2_Silent_p.T769T|POM121_uc010lam.1_Silent_p.T769T	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1034	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				GCGGTGCCACGCACTCGGCGT	0.652													18	154					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87913172	87913172	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:87913172G>C	uc003ujs.2	-	2	518	c.413C>G	c.(412-414)TCA>TGA	p.S138*	STEAP4_uc010lek.2_Nonsense_Mutation_p.S138*|STEAP4_uc003ujt.2_Nonsense_Mutation_p.S138*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	138					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					AGCCCAGGCTGAGATGGTGTT	0.418													404	101					0	0	0	0
PIK3CG	5294	broad.mit.edu	37	7	106513012	106513012	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:106513012G>A	uc003vdv.3	+	3	2111	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T	PIK3CG_uc003vdu.2_Missense_Mutation_p.A676T|PIK3CG_uc003vdw.2_Missense_Mutation_p.A676T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	676					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCATGATAGCGCCCTTGCCAG	0.393													78	116					0	0	0	0
DOCK5	80005	broad.mit.edu	37	8	25154152	25154152	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:25154152C>T	uc003xeg.2	+	7	731	c.594C>T	c.(592-594)ATC>ATT	p.I198I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_5'UTR|DOCK5_uc003xef.2_Silent_p.I198I	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	198						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGGAAAAGATCCAAGAAGAGA	0.448													8	14					0	0	0	0
CDCA2	157313	broad.mit.edu	37	8	25365207	25365207	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:25365207C>G	uc003xep.1	+	15	3504	c.3025C>G	c.(3025-3027)CTG>GTG	p.L1009V	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.L994V|CDCA2_uc003xer.1_Missense_Mutation_p.L672V	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1009					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGAGAGCTCTCTGACTGCCTT	0.433													15	99					0	0	0	0
KIAA0146	23514	broad.mit.edu	37	8	48614380	48614380	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:48614380A>G	uc003xqd.2	+	13	1880	c.1871A>G	c.(1870-1872)AAG>AGG	p.K624R	KIAA0146_uc011ldb.1_Missense_Mutation_p.K624R|KIAA0146_uc010lxs.2_Missense_Mutation_p.K99R|KIAA0146_uc011ldc.1_Missense_Mutation_p.K554R|KIAA0146_uc011ldd.1_Missense_Mutation_p.K564R|KIAA0146_uc003xqe.2_Missense_Mutation_p.K99R|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.K313R|KIAA0146_uc010lxt.2_Missense_Mutation_p.K313R|KIAA0146_uc011ldf.1_Missense_Mutation_p.K129R|KIAA0146_uc011ldg.1_Missense_Mutation_p.K114R|KIAA0146_uc010lxv.1_Missense_Mutation_p.K118R	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	624											0		Lung NSC(58;0.175)				CCCATTTATAAGCTTTACCAG	0.428													91	170					0	0	0	0
TRPA1	8989	broad.mit.edu	37	8	72948640	72948640	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:72948640G>A	uc003xza.2	-	21	2613	c.2438C>T	c.(2437-2439)ACG>ATG	p.T813M	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	813	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GATGCCCGTCGTGTAGATAAT	0.363													14	53					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104987601	104987601	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:104987601C>G	uc003yls.2	+	14	2369	c.2128C>G	c.(2128-2130)CTT>GTT	p.L710V	RIMS2_uc003ylp.2_Missense_Mutation_p.L932V|RIMS2_uc003ylw.2_Missense_Mutation_p.L724V|RIMS2_uc003ylq.2_Missense_Mutation_p.L724V|RIMS2_uc003ylr.2_Missense_Mutation_p.L771V|RIMS2_uc003ylt.2_Missense_Mutation_p.L317V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	994					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTCGAGATCTTCAAAGCTC	0.358										HNSCC(12;0.0054)			8	29					0	0	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361225	105361225	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:105361225C>T	uc003ylx.1	+	2	494	c.445C>T	c.(445-447)CAG>TAG	p.Q149*		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	149					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGAGGCAATTCAGTGGATTTA	0.418													14	84					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113988168	113988168	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:113988168C>A	uc003ynu.2	-	7	1399	c.1240G>T	c.(1240-1242)GGG>TGG	p.G414W	CSMD3_uc003ynt.2_Missense_Mutation_p.G374W|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	414	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGAGAGAGCCCGTCCTTGGAC	0.478										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	117					6.33239e-15	2.34132e-14	1	0
COL22A1	169044	broad.mit.edu	37	8	139601580	139601580	+	Silent	SNP	G	A	A			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:139601580G>A	uc003yvd.2	-	65	5244	c.4797C>T	c.(4795-4797)CCC>CCT	p.P1599P	COL22A1_uc011ljo.1_Silent_p.P879P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1599	Pro-rich.|Gly-rich.|Collagen-like 16.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGGGGACCGGGAGGTCCTG	0.622										HNSCC(7;0.00092)			7	36					0	0	0	0
ZNF250	58500	broad.mit.edu	37	8	146107136	146107136	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:146107136C>G	uc003zeq.3	-	6	1564	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.E478Q|ZNF250_uc010mgg.2_Missense_Mutation_p.E478Q	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	483	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TTGCCACATTCTGTGCACTGG	0.552													7	41					0	0	0	0
ZNF250	58500	broad.mit.edu	37	8	146107269	146107269	+	Silent	SNP	C	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:146107269C>G	uc003zeq.3	-	6	1431	c.1314G>C	c.(1312-1314)CTG>CTC	p.L438L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.L433L|ZNF250_uc010mgg.2_Silent_p.L433L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	438	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		GGTGCTGGATCAGGTGTGAGT	0.567													11	62					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72131553	72131553	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr9:72131553C>T	uc004ahh.2	-	2	850	c.574G>A	c.(574-576)GGC>AGC	p.G192S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	192					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCCTGGAGGCCGCCGTAGTCG	0.687													5	26					0	0	0	0
SYK	6850	broad.mit.edu	37	9	93650902	93650902	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr9:93650902A>G	uc004aqz.2	+	13	2033	c.1828A>G	c.(1828-1830)ACA>GCA	p.T610A	SYK_uc004ara.2_Missense_Mutation_p.T587A|SYK_uc004arb.2_Missense_Mutation_p.T587A|SYK_uc004arc.2_Missense_Mutation_p.T610A|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	610	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TCTGTGCTGGACATACGAGTG	0.463			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								7	18					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	118997917	118997917	+	Splice_Site	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr9:118997917G>T	uc004bjn.2	+	7	3113	c.2732_splice	c.e7+1	p.M911_splice	PAPPA_uc011lxp.1_Splice_Site_p.M606_splice|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A						cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TCGTAGACATGTAAGTGCATT	0.507													42	103					5.2432e-18	1.96445e-17	1	0
BAT2L1	84726	broad.mit.edu	37	9	134343088	134343088	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr9:134343088A>G	uc004can.3	+	12	1914	c.1859A>G	c.(1858-1860)TAT>TGT	p.Y620C	BAT2L1_uc010mzj.1_Missense_Mutation_p.Y203C	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	620	Gln-rich.						protein binding				0						GAGTTCAAGTATCAGAAGTCC	0.557													20	45					0	0	0	0
ASMT	438	broad.mit.edu	37	X	1752052	1752052	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:1752052G>C	uc004cqd.2	+	8	801	c.656G>C	c.(655-657)GGA>GCA	p.G219A	ASMT_uc010ncy.2_Missense_Mutation_p.G219A|ASMT_uc004cqe.2_Intron	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	191					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTGGGGCTGGAGCTCTGGCT	0.537													39	172					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811511	5811511	+	Silent	SNP	A	G	G			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:5811511A>G	uc010ndh.2	-	6	2299	c.1798T>C	c.(1798-1800)TTG>CTG	p.L600L	NLGN4X_uc004crp.2_Silent_p.L620L|NLGN4X_uc004crq.2_Silent_p.L600L|NLGN4X_uc010ndi.2_Silent_p.L637L|NLGN4X_uc004crr.2_Silent_p.L600L|NLGN4X_uc010ndj.2_Silent_p.L600L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	600	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ATCTCGTTCAAGTTGTGCAAA	0.483													49	38					0	0	0	0
FAM47B	170062	broad.mit.edu	37	X	34961338	34961338	+	Silent	SNP	C	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:34961338C>T	uc004ddi.1	+	1	408	c.390C>T	c.(388-390)CCC>CCT	p.P130P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	130										ovary(3)|breast(1)	4						CCAAGCATCCCTTGGCCATGT	0.557													40	22					0	0	0	0
COL4A5	1287	broad.mit.edu	37	X	107924156	107924156	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:107924156G>T	uc004enz.1	+	45	4259	c.4057G>T	c.(4057-4059)GAG>TAG	p.E1353*	COL4A5_uc011mso.1_Nonsense_Mutation_p.E1350*|COL4A5_uc011msp.1_Nonsense_Mutation_p.E29*	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1347	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGCTGGCCCTGAGGGGGAACC	0.448									Alport_syndrome_with_Diffuse_Leiomyomatosis				51	25					1.86277e-20	7.07349e-20	1	0
CT47B1	643311	broad.mit.edu	37	X	120008849	120008850	+	Nonsense_Mutation	DNP	TC	AG	AG			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:120008849_120008850TC>AG	uc011muc.1	-	1	930_931	c.675_676GA>CT	c.(673-678)GAGAAA>GACTAA	p.225_226EK>D*		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	225_226											0						tctgGGGGTTTCTCATCTGCGG	0.559													6	136					0	0	0	0
Unknown	0	broad.mit.edu	37	10	29187879	29187879	+	IGR	DEL	T	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr10:29187879delT								BAMBI (216011 upstream) : LYZL1 (390111 downstream)																							CAGAAATTTCTTTTTTTTTTT	0.308													---	---	---							
Unknown	0	broad.mit.edu	37	10	82009414	82009415	+	IGR	INS	-	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr10:82009414_82009415insC								ANXA11 (43981 upstream) : MAT1A (22162 downstream)																							TGCAAGAAAGGCCTCAACAACT	0.460													---	---	---							
HEATR5B	54497	broad.mit.edu	37	2	37234297	37234298	+	In_Frame_Ins	INS	-	AACCAG	AACCAG			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:37234297_37234298insAACCAG	uc002rpp.1	-	29	4768_4769	c.4672_4673insCTGGTT	c.(4672-4674)TTA>TCTGGTTTA	p.1557_1558insSG	HEATR5B_uc010ezy.1_In_Frame_Ins_p.141_142insSG	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1557_1558							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACGTTTTTGTAAACCAGATATT	0.431													---	---	---							
Unknown	0	broad.mit.edu	37	7	20042879	20042879	+	IGR	DEL	A	-	-	rs34222141		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:20042879delA								TMEM196 (229663 upstream) : MACC1 (131409 downstream)																							AATAGGTGTTAAAAAAAAAAA	0.333													---	---	---							
Unknown	0	broad.mit.edu	37	7	55004034	55004034	+	IGR	DEL	T	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:55004034delT								SEC61G (177095 upstream) : EGFR (82691 downstream)																							GCCAAGCAGATTTTTTTTTTG	0.368													---	---	---							
NRCAM	4897	broad.mit.edu	37	7	107820812	107820813	+	Frame_Shift_Ins	INS	-	T	T	rs139634064		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:107820812_107820813insT	uc003vfb.2	-	25	3176_3177	c.2705_2706insA	c.(2704-2706)AAGfs	p.K902fs	NRCAM_uc003vfc.2_Frame_Shift_Ins_p.K886fs|NRCAM_uc011kmk.1_Frame_Shift_Ins_p.K897fs|NRCAM_uc003vfd.2_Frame_Shift_Ins_p.K878fs|NRCAM_uc003vfe.2_Frame_Shift_Ins_p.K878fs	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	902	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						AGGTGAGGATCTTTTTCTCAAT	0.470													---	---	---							
LRP12	29967	broad.mit.edu	37	8	105521276	105521276	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:105521276delG	uc003yma.2	-	3	258	c.163delC	c.(163-165)CGAfs	p.R55fs	LRP12_uc003ymb.2_Frame_Shift_Del_p.R36fs|LRP12_uc003ymc.3_Frame_Shift_Del_p.R36fs	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	55	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGGTGCTCGTATTTGCTCT	0.408													---	---	---							
NKAP	79576	broad.mit.edu	37	X	119077333	119077338	+	In_Frame_Del	DEL	CGCGAC	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:119077333_119077338delCGCGAC	uc004esh.2	-	1	398_403	c.231_236delGTCGCG	c.(229-237)CGGTCGCGT>CGT	p.77_79RSR>R		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	77_79	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						CTCTCTAGAACGCGACCGCGAGCGTG	0.660													---	---	---							
Unknown	0	broad.mit.edu	37	10	82009414	82009415	+	IGR	INS	-	C	C			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr10:82009414_82009415insC								ANXA11 (43981 upstream) : MAT1A (22162 downstream)																							TGCAAGAAAGGCCTCAACAACT	0.460													---	---	---							
Unknown	0	broad.mit.edu	37	12	53535721	53535722	+	IGR	INS	-	A	A	rs141513257		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:53535721_53535722insA								SOAT2 (17399 upstream) : CSAD (15726 downstream)																							aaaaaaaaaagaaaaaaaaaaa	0.252													---	---	---							
Unknown	0	broad.mit.edu	37	12	119145610	119145615	+	IGR	DEL	CGGTGA	-	-	rs142209741	by1000genomes	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:119145610_119145615delCGGTGA								SUDS3 (289771 upstream) : SRRM4 (273781 downstream)																							gtgatggtggcggtgatggtgatggt	0.000													---	---	---							
HEATR5B	54497	broad.mit.edu	37	2	37234297	37234298	+	In_Frame_Ins	INS	-	AACCAG	AACCAG			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr2:37234297_37234298insAACCAG	uc002rpp.1	-	29	4768_4769	c.4672_4673insCTGGTT	c.(4672-4674)TTA>TCTGGTTTA	p.1557_1558insSG	HEATR5B_uc010ezy.1_In_Frame_Ins_p.141_142insSG	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1557_1558							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACGTTTTTGTAAACCAGATATT	0.431													---	---	---							
Unknown	0	broad.mit.edu	37	3	161146872	161146873	+	IGR	DEL	AT	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr3:161146872_161146873delAT								C3orf57 (57001 upstream) : OTOL1 (67723 downstream)																							TGGTGAAAAGATATATATATAT	0.342													---	---	---							
Unknown	0	broad.mit.edu	37	4	49506430	49506430	+	IGR	DEL	T	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr4:49506430delT								CWH43 (442337 upstream) : None (None downstream)																							TTCTTCTCTATTTTTTTGTAC	0.279													---	---	---							
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr5:140052285delT	uc003lgt.2	-	3	393	c.349delA	c.(349-351)ACGfs	p.T117fs		NM_194249	NP_919225	Q8IYX4	DND1_HUMAN	dead end homolog 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													---	---	---							
NRCAM	4897	broad.mit.edu	37	7	107820812	107820813	+	Frame_Shift_Ins	INS	-	T	T	rs139634064		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr7:107820812_107820813insT	uc003vfb.2	-	25	3176_3177	c.2705_2706insA	c.(2704-2706)AAGfs	p.K902fs	NRCAM_uc003vfc.2_Frame_Shift_Ins_p.K886fs|NRCAM_uc011kmk.1_Frame_Shift_Ins_p.K897fs|NRCAM_uc003vfd.2_Frame_Shift_Ins_p.K878fs|NRCAM_uc003vfe.2_Frame_Shift_Ins_p.K878fs	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	902	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						AGGTGAGGATCTTTTTCTCAAT	0.470													---	---	---							
LRP12	29967	broad.mit.edu	37	8	105521276	105521276	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr8:105521276delG	uc003yma.2	-	3	258	c.163delC	c.(163-165)CGAfs	p.R55fs	LRP12_uc003ymb.2_Frame_Shift_Del_p.R36fs|LRP12_uc003ymc.3_Frame_Shift_Del_p.R36fs	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	55	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGGTGCTCGTATTTGCTCT	0.408													---	---	---							
NKAP	79576	broad.mit.edu	37	X	119077333	119077338	+	In_Frame_Del	DEL	CGCGAC	-	-			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chrX:119077333_119077338delCGCGAC	uc004esh.2	-	1	398_403	c.231_236delGTCGCG	c.(229-237)CGGTCGCGT>CGT	p.77_79RSR>R		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	77_79	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						CTCTCTAGAACGCGACCGCGAGCGTG	0.660													---	---	---							
