Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
TAS1R3	83756	broad.mit.edu	37	1	1267896	1267896	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:1267896G>A	uc010nyk.1	+	3	985	c.985G>A	c.(985-987)GCC>ACC	p.A329T		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	329	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCAGAGGGGTGCCCAGCTGCA	0.692													7	26	---	---	---	---	PASS
PADI4	23569	broad.mit.edu	37	1	17674483	17674483	+	Silent	SNP	C	A	A	rs144009145	byFrequency	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:17674483C>A	uc001baj.2	+	10	1123	c.1095C>A	c.(1093-1095)CCC>CCA	p.P365P	PADI4_uc009vpc.2_Silent_p.P365P	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	365					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AAACGCTGCCCGTGGTCTTCG	0.592													7	25	---	---	---	---	PASS
PLA2G2F	64600	broad.mit.edu	37	1	20474719	20474719	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:20474719G>A	uc009vpp.1	+	5	559	c.461G>A	c.(460-462)TGC>TAC	p.C154Y		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	111					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		AAGCAGACATGCATGTGTGAC	0.567													25	56	---	---	---	---	PASS
SRRM1	10250	broad.mit.edu	37	1	24995804	24995804	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:24995804A>G	uc001bjm.2	+	14	2154	c.1930A>G	c.(1930-1932)AGA>GGA	p.R644G	SRRM1_uc010oel.1_Missense_Mutation_p.R656G|SRRM1_uc009vrh.1_Missense_Mutation_p.R617G|SRRM1_uc009vri.1_Missense_Mutation_p.R573G	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	644	Pro-rich.|Necessary for speckles and matrix localization.|Arg-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TCCCAAACAAAGAAGCTCCCC	0.552													14	37	---	---	---	---	PASS
TCTEX1D1	200132	broad.mit.edu	37	1	67243030	67243030	+	Nonsense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:67243030G>T	uc001dcv.2	+	5	564	c.433G>T	c.(433-435)GGA>TGA	p.G145*	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	145											0						CATACTTATTGGAAGCAGATG	0.393													42	88	---	---	---	---	PASS
AK5	26289	broad.mit.edu	37	1	77752625	77752625	+	Splice_Site	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:77752625G>T	uc001dhn.2	+	2	318	c.61_splice	c.e2-1	p.S21_splice	AK5_uc001dho.2_Intron|AK5_uc001dhm.1_Splice_Site_p.S21_splice	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1						ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						TTATATTTCAGAGCCTTTTGA	0.274													11	43	---	---	---	---	PASS
GSTM5	2949	broad.mit.edu	37	1	110255794	110255794	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:110255794G>T	uc001dyn.2	+	3	237	c.166G>T	c.(166-168)GAC>TAC	p.D56Y	GSTM5_uc010ovu.1_5'UTR	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	56	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	GCTGGGCCTGGACTTTCCCAA	0.537													16	53	---	---	---	---	PASS
HORMAD1	84072	broad.mit.edu	37	1	150680853	150680853	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:150680853C>G	uc001evk.1	-	9	532	c.426G>C	c.(424-426)TTG>TTC	p.L142F	HORMAD1_uc001evl.1_Missense_Mutation_p.L135F|HORMAD1_uc001evm.1_Missense_Mutation_p.L62F	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	142	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGTCAGTAGACAACATGCTAG	0.328													15	38	---	---	---	---	PASS
OR6Y1	391112	broad.mit.edu	37	1	158516935	158516935	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:158516935C>G	uc010pil.1	-	1	961	c.961G>C	c.(961-963)GGG>CGG	p.G321R		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTGAAAGCCCCATTTCCCTGG	0.463													18	45	---	---	---	---	PASS
OR6Y1	391112	broad.mit.edu	37	1	158517161	158517161	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:158517161G>T	uc010pil.1	-	1	735	c.735C>A	c.(733-735)ACC>ACA	p.T245T		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGGAGGCACAGGTGGAGAATG	0.507													5	49	---	---	---	---	PASS
OR6Y1	391112	broad.mit.edu	37	1	158517162	158517162	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:158517162G>T	uc010pil.1	-	1	734	c.734C>A	c.(733-735)ACC>AAC	p.T245N		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAGGCACAGGTGGAGAATGC	0.502													5	49	---	---	---	---	PASS
SPTA1	6708	broad.mit.edu	37	1	158615049	158615049	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:158615049G>A	uc001fst.1	-	29	4322	c.4123C>T	c.(4123-4125)CTA>TTA	p.L1375L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1375	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCTCTCTCTAGCTTGACAGCT	0.478													29	97	---	---	---	---	PASS
OR10J3	441911	broad.mit.edu	37	1	159283536	159283536	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:159283536C>T	uc010piu.1	-	1	914	c.914G>A	c.(913-915)CGT>CAT	p.R305H		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TTTTGCCCCACGGCTCTGTGC	0.428													24	66	---	---	---	---	PASS
RABGAP1L	9910	broad.mit.edu	37	1	174188304	174188304	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:174188304C>T	uc001gjx.2	+	2	204	c.9C>T	c.(7-9)GTC>GTT	p.V3V	RABGAP1L_uc009wwq.1_Silent_p.V3V|RABGAP1L_uc001gjw.2_Silent_p.V3V	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	3					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						AAATGGAGGTCAGAGCTTCAT	0.353													5	31	---	---	---	---	PASS
TDRD5	163589	broad.mit.edu	37	1	179631350	179631350	+	Missense_Mutation	SNP	G	A	A	rs145054790		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:179631350G>A	uc001gnf.1	+	14	2522	c.2272G>A	c.(2272-2274)GCC>ACC	p.A758T	TDRD5_uc010pnp.1_Missense_Mutation_p.A812T|TDRD5_uc001gnh.1_Missense_Mutation_p.A313T	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	758					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AGGTGATGCTGCCTCCCATCT	0.433													13	48	---	---	---	---	PASS
PLA2G4A	5321	broad.mit.edu	37	1	186934540	186934540	+	Splice_Site	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:186934540G>T	uc001gsc.2	+	15	1785	c.1580_splice	c.e15-1	p.D527_splice	PLA2G4A_uc010pos.1_Splice_Site_p.D467_splice	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA						phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATGTTTTTAAGATCCTGATGA	0.308													12	33	---	---	---	---	PASS
F13B	2165	broad.mit.edu	37	1	197021801	197021801	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:197021801G>T	uc001gtt.1	-	9	1562	c.1518C>A	c.(1516-1518)AAC>AAA	p.N506K		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	506	Sushi 8.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CTTCTCCTCTGTTGCACTGCA	0.343													16	36	---	---	---	---	PASS
KDM5B	10765	broad.mit.edu	37	1	202724408	202724408	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:202724408T>C	uc001gyf.2	-	11	1645	c.1529A>G	c.(1528-1530)TAC>TGC	p.Y510C	KDM5B_uc009xag.2_Missense_Mutation_p.Y546C|KDM5B_uc001gyg.1_Missense_Mutation_p.Y352C	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	510	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CCAGTGCAAGTAGTTAATTGA	0.408													24	58	---	---	---	---	PASS
KCNH1	3756	broad.mit.edu	37	1	211093036	211093036	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:211093036C>A	uc001hib.2	-	7	1578	c.1408G>T	c.(1408-1410)GCC>TCC	p.A470S	KCNH1_uc001hic.2_Missense_Mutation_p.A443S	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	470					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GTGGATGGGGCGATGTTCCCA	0.507													4	107	---	---	---	---	PASS
LEFTY1	10637	broad.mit.edu	37	1	226075599	226075599	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:226075599G>T	uc001hpo.2	-	2	454	c.384C>A	c.(382-384)GCC>GCA	p.A128A	LEFTY1_uc010pvj.1_Missense_Mutation_p.R237S|LEFTY1_uc009xej.1_Silent_p.A128A	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	128					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					TGTGCAGCGCGGCCTTGGGGA	0.746													3	2	---	---	---	---	PASS
FMN2	56776	broad.mit.edu	37	1	240255953	240255953	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:240255953G>T	uc010pyd.1	+	1	769	c.544G>T	c.(544-546)GAC>TAC	p.D182Y	FMN2_uc010pye.1_Missense_Mutation_p.D182Y	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	182					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCGGACACGGACATCTATAG	0.532													13	25	---	---	---	---	PASS
OR2W3	343171	broad.mit.edu	37	1	248059542	248059542	+	Nonsense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr1:248059542C>G	uc001idp.1	+	3	923	c.654C>G	c.(652-654)TAC>TAG	p.Y218*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.Y218*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGCTCTCTTACAGCTACATTG	0.567													40	127	---	---	---	---	PASS
WDR35	57539	broad.mit.edu	37	2	20113879	20113879	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:20113879T>C	uc002rdi.2	-	27	3422	c.3314A>G	c.(3313-3315)TAT>TGT	p.Y1105C	WDR35_uc002rdj.2_Missense_Mutation_p.Y1094C|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	1105										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGGTCTTCATACTGCTGTTT	0.398													42	68	---	---	---	---	PASS
C2orf84	653140	broad.mit.edu	37	2	24413499	24413499	+	Nonstop_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:24413499G>T	uc002rfc.2	+	6	706	c.620G>T	c.(619-621)TGA>TTA	p.*207L	C2orf84_uc010eyc.2_RNA	NM_001040710	NP_001035800	Q86W67	CB084_HUMAN	hypothetical protein LOC653140	207											0						GTTCCAGAATGAGCCACCGCC	0.617													6	27	---	---	---	---	PASS
GALNT14	79623	broad.mit.edu	37	2	31133804	31133804	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:31133804G>A	uc002rnr.2	-	15	2241	c.1622C>T	c.(1621-1623)TCA>TTA	p.S541L	GALNT14_uc002rnq.2_Missense_Mutation_p.S521L|GALNT14_uc002rns.2_Missense_Mutation_p.S546L|GALNT14_uc010ymr.1_Missense_Mutation_p.S506L	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	541	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCTCATGAGTGAGGACTCACA	0.567													22	56	---	---	---	---	PASS
MEMO1	51072	broad.mit.edu	37	2	32117201	32117201	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:32117201T>C	uc002rnx.2	-	6	822	c.440A>G	c.(439-441)CAT>CGT	p.H147R	MEMO1_uc010ymu.1_Missense_Mutation_p.H124R|MEMO1_uc010ezq.2_Missense_Mutation_p.H147R|MEMO1_uc002rny.2_Intron|MEMO1_uc002rnz.2_RNA	NM_015955	NP_057039	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1 isoform 1	147					regulation of microtubule-based process	cytosol|nucleus				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					CTCATCCTTATGGCTTAAAGA	0.328													39	70	---	---	---	---	PASS
C2orf63	130162	broad.mit.edu	37	2	55435829	55435829	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:55435829C>A	uc002ryi.2	-	8	1178	c.832G>T	c.(832-834)GAA>TAA	p.E278*	C2orf63_uc002ryh.2_Intron|C2orf63_uc002ryj.2_Nonsense_Mutation_p.E156*	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	278							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			ATTAGTTCTTCAACAATGCCT	0.313													47	63	---	---	---	---	PASS
MPHOSPH10	10199	broad.mit.edu	37	2	71376518	71376518	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:71376518A>T	uc002sht.1	+	10	2183	c.1831A>T	c.(1831-1833)AGC>TGC	p.S611C		NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	611					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AGGGAAATACAGCAAAACAGT	0.408													19	17	---	---	---	---	PASS
DYSF	8291	broad.mit.edu	37	2	71743340	71743340	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:71743340G>T	uc002sie.2	+	8	1199	c.823G>T	c.(823-825)GGG>TGG	p.G275W	DYSF_uc010feg.2_Missense_Mutation_p.G306W|DYSF_uc010feh.2_Missense_Mutation_p.G275W|DYSF_uc002sig.3_Missense_Mutation_p.G275W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.G275W|DYSF_uc010fef.2_Missense_Mutation_p.G306W|DYSF_uc010fei.2_Missense_Mutation_p.G306W|DYSF_uc010fek.2_Missense_Mutation_p.G307W|DYSF_uc010fej.2_Missense_Mutation_p.G276W|DYSF_uc010fel.2_Missense_Mutation_p.G276W|DYSF_uc010feo.2_Missense_Mutation_p.G307W|DYSF_uc010fem.2_Missense_Mutation_p.G276W|DYSF_uc010fen.2_Missense_Mutation_p.G307W|DYSF_uc002sif.2_Missense_Mutation_p.G276W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	275	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGACTCTCCTGGGGAGCTGTT	0.502													21	25	---	---	---	---	PASS
HK2	3099	broad.mit.edu	37	2	75113668	75113668	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:75113668T>A	uc002snd.2	+	15	4013	c.2087T>A	c.(2086-2088)GTG>GAG	p.V696E		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	696	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GTGGAACTGGTGGAAGGAGAA	0.572													10	67	---	---	---	---	PASS
REG1A	5967	broad.mit.edu	37	2	79349183	79349183	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:79349183G>C	uc002snz.2	+	4	356	c.253G>C	c.(253-255)GCC>CCC	p.A85P	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.A85P	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	85	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TGCCTTTGTGGCCTCACTGAT	0.507													43	76	---	---	---	---	PASS
LRRTM1	347730	broad.mit.edu	37	2	80530771	80530771	+	Silent	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:80530771G>C	uc002sok.1	-	2	444	c.174C>G	c.(172-174)ACC>ACG	p.T58T	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	58	LRRNT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGGGCGCCTCGGTGAGGTTGA	0.701										HNSCC(69;0.2)			11	49	---	---	---	---	PASS
DBI	1622	broad.mit.edu	37	2	120129848	120129848	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:120129848C>G	uc002tlv.2	+	4	342	c.218C>G	c.(217-219)GCT>GGT	p.A73G	DBI_uc010yyh.1_Missense_Mutation_p.A90G|DBI_uc010yyi.1_Missense_Mutation_p.A90G|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Missense_Mutation_p.A115G|DBI_uc010yyl.1_Missense_Mutation_p.A90G|DBI_uc010yym.1_Missense_Mutation_p.A83G|DBI_uc010yyn.1_Missense_Mutation_p.A90G|DBI_uc002tlw.2_Missense_Mutation_p.A90G|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Missense_Mutation_p.A74G	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	73	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						GCCATGAAAGCTTACATCAAC	0.448													18	58	---	---	---	---	PASS
MYO7B	4648	broad.mit.edu	37	2	128394440	128394440	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:128394440G>A	uc002top.2	+	46	6254	c.6201G>A	c.(6199-6201)GCG>GCA	p.A2067A	MYO7B_uc002tos.1_Silent_p.A177A|MYO7B_uc002tot.2_Silent_p.A177A	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2067	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCCACATGGCGCTGGGGAGCC	0.637													9	50	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133531428	133531428	+	Missense_Mutation	SNP	C	A	A	rs150198489	by1000genomes	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:133531428C>A	uc002ttp.2	-	16	5463	c.5089G>T	c.(5089-5091)GAT>TAT	p.D1697Y	NCKAP5_uc002ttq.2_Missense_Mutation_p.D378Y	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1697							protein binding				0						GCAACTGCATCGTCTTCATCC	0.333													22	90	---	---	---	---	PASS
TBR1	10716	broad.mit.edu	37	2	162276709	162276709	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:162276709T>G	uc002ubw.1	+	5	1433	c.1131T>G	c.(1129-1131)ATT>ATG	p.I377M	TBR1_uc010foy.2_Missense_Mutation_p.I90M	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	377	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TTTGCCAGATTACACAACTGA	0.358													3	56	---	---	---	---	PASS
SLC38A11	151258	broad.mit.edu	37	2	165802148	165802148	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:165802148C>A	uc002ucv.1	-	5	688	c.151G>T	c.(151-153)GGG>TGG	p.G51W	SLC38A11_uc002ucu.1_Missense_Mutation_p.G51W|SLC38A11_uc002ucw.1_Missense_Mutation_p.G51W	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	51	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						AGCAGATACCCTGGAAAGCCG	0.388													12	60	---	---	---	---	PASS
SCN7A	6332	broad.mit.edu	37	2	167328866	167328866	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:167328866T>A	uc002udu.1	-	5	660	c.533A>T	c.(532-534)GAT>GTT	p.D178V	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	178					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						GTTCCATGGATCACCGAGGAA	0.353													3	7	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179422805	179422805	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:179422805A>G	uc010zfg.1	-	277	79796	c.79572T>C	c.(79570-79572)AAT>AAC	p.N26524N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.N20219N|TTN_uc010zfi.1_Silent_p.N20152N|TTN_uc010zfj.1_Silent_p.N20027N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27451							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATTTCGGTATTAAATCTCA	0.428													29	66	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179455978	179455978	+	Silent	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:179455978A>T	uc010zfg.1	-	253	52994	c.52770T>A	c.(52768-52770)GGT>GGA	p.G17590G	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.G11285G|TTN_uc010zfi.1_Silent_p.G11218G|TTN_uc010zfj.1_Silent_p.G11093G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTTTTGCTACCGGCTGCAT	0.418													11	245	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179611166	179611166	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:179611166C>A	uc002unb.2	-	46	16185	c.15961G>T	c.(15961-15963)GTT>TTT	p.V5321F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCTTTAACGTCTTTTTCA	0.363													11	39	---	---	---	---	PASS
NRP2	8828	broad.mit.edu	37	2	206631516	206631516	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:206631516C>A	uc002vaw.2	+	15	3205	c.2414C>A	c.(2413-2415)TCG>TAG	p.S805*	NRP2_uc002vau.2_Nonsense_Mutation_p.S805*|NRP2_uc002vav.2_Nonsense_Mutation_p.S805*|NRP2_uc002vax.2_Nonsense_Mutation_p.S805*|NRP2_uc002vay.2_Nonsense_Mutation_p.S805*	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	805	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GAACCCATCTCGGCTTTTGCA	0.333											OREG0015156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	76	---	---	---	---	PASS
TTLL4	9654	broad.mit.edu	37	2	219614020	219614020	+	Missense_Mutation	SNP	G	T	T	rs138019885	byFrequency	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:219614020G>T	uc002viy.2	+	14	3015	c.2645G>T	c.(2644-2646)CGG>CTG	p.R882L	TTLL4_uc010zkl.1_Missense_Mutation_p.R717L|TTLL4_uc010fvx.2_Missense_Mutation_p.R818L|TTLL4_uc010zkm.1_Missense_Mutation_p.R85L	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	882	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TATGTGCGACGGCCCTATAGC	0.522													12	42	---	---	---	---	PASS
ATG9A	79065	broad.mit.edu	37	2	220089411	220089411	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr2:220089411G>A	uc002vke.1	-	8	868	c.682C>T	c.(682-684)CTG>TTG	p.L228L	ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.L228L	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	228	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCAGAGGCAGGAGGGATTTG	0.557													15	57	---	---	---	---	PASS
CCR4	1233	broad.mit.edu	37	3	32994962	32994962	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:32994962C>A	uc003cfg.1	+	2	216	c.48C>A	c.(46-48)TAC>TAA	p.Y16*		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	16	Extracellular (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						AAAGCATATACAGCAATTACT	0.488													15	24	---	---	---	---	PASS
SCN10A	6336	broad.mit.edu	37	3	38791575	38791575	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:38791575G>T	uc003ciq.2	-	12	1856	c.1856C>A	c.(1855-1857)TCC>TAC	p.S619Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	619					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTCAAGGACGGAGGTTATGAT	0.458													9	16	---	---	---	---	PASS
XIRP1	165904	broad.mit.edu	37	3	39228203	39228203	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:39228203G>T	uc003cjk.1	-	2	2955	c.2734C>A	c.(2734-2736)CTG>ATG	p.L912M	XIRP1_uc003cji.2_Missense_Mutation_p.L912M|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	912							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CGGGGCTGCAGAGAGTAGGCA	0.622													12	22	---	---	---	---	PASS
LZTFL1	54585	broad.mit.edu	37	3	45879503	45879503	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:45879503A>T	uc003cox.1	-	2	182	c.44T>A	c.(43-45)ATT>AAT	p.I15N	LZTFL1_uc003coy.1_5'UTR|LZTFL1_uc011bak.1_Intron	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	15											0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CATATAATTAATAACTTCATT	0.393													7	35	---	---	---	---	PASS
VPRBP	9730	broad.mit.edu	37	3	51475638	51475638	+	Silent	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:51475638T>C	uc003dbe.1	-	8	957	c.789A>G	c.(787-789)GGA>GGG	p.G263G	VPRBP_uc003dbg.1_Silent_p.G263G	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	263					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TTTTCTTTAATCCTCCATCCT	0.433													63	85	---	---	---	---	PASS
DPPA4	55211	broad.mit.edu	37	3	109049395	109049395	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:109049395C>A	uc003dxq.3	-	5	710	c.655G>T	c.(655-657)GTG>TTG	p.V219L	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Missense_Mutation_p.V219L	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	219						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GGAGATTCCACTGCCTCTGGT	0.493													19	43	---	---	---	---	PASS
CCDC14	64770	broad.mit.edu	37	3	123663744	123663744	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:123663744A>T	uc011bjx.1	-	9	1530	c.1439T>A	c.(1438-1440)ATA>AAA	p.I480K	CCDC14_uc003egv.3_Missense_Mutation_p.I121K|CCDC14_uc003egx.3_Missense_Mutation_p.I280K|CCDC14_uc010hrt.2_Missense_Mutation_p.I439K|CCDC14_uc003egy.3_Missense_Mutation_p.I280K|CCDC14_uc003egz.2_Missense_Mutation_p.I280K	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	480						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GGCCAGTGCTATCTCAACTTG	0.383													9	17	---	---	---	---	PASS
KALRN	8997	broad.mit.edu	37	3	124438217	124438217	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:124438217G>A	uc003ehg.2	+	60	8988	c.8861G>A	c.(8860-8862)CGC>CAC	p.R2954H	KALRN_uc003ehk.2_Missense_Mutation_p.R1257H	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2953					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GACACCTCCCGCCTAGCATGC	0.552													14	33	---	---	---	---	PASS
HEG1	57493	broad.mit.edu	37	3	124746240	124746240	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:124746240C>T	uc003ehs.3	-	3	790	c.722G>A	c.(721-723)GGG>GAG	p.G241E	HEG1_uc011bke.1_Missense_Mutation_p.G241E	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	241	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						TTCTGACAGCCCCATCGCCCT	0.547													6	19	---	---	---	---	PASS
ZXDC	79364	broad.mit.edu	37	3	126180940	126180940	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:126180940G>C	uc003eiv.2	-	6	1619	c.1565C>G	c.(1564-1566)GCT>GGT	p.A522G	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.A522G	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	522					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		AGAACCACTAGCATTGGCAGG	0.547													32	54	---	---	---	---	PASS
ACPP	55	broad.mit.edu	37	3	132075647	132075647	+	Silent	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:132075647T>C	uc010htp.2	+	10	1176	c.1086T>C	c.(1084-1086)CCT>CCC	p.P362P	ACPP_uc003eon.3_Silent_p.P329P|ACPP_uc003eop.3_Silent_p.P362P	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	362						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						TGGTTGGCCCTGTGATCCCTC	0.537													4	102	---	---	---	---	PASS
LRRIQ4	344657	broad.mit.edu	37	3	169540634	169540634	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:169540634G>T	uc003fgb.2	+	1	925	c.925G>T	c.(925-927)GAC>TAC	p.D309Y		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	309	LRR 13.										0						GCGCTTCCTGGACCTAAGCCA	0.572													7	21	---	---	---	---	PASS
GNB4	59345	broad.mit.edu	37	3	179123052	179123052	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:179123052C>A	uc003fjv.3	-	9	1122	c.842G>T	c.(841-843)AGT>ATT	p.S281I	GNB4_uc003fju.3_Intron	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	281	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			GAGACGCCCACTTTTTGAGAA	0.418													3	64	---	---	---	---	PASS
TTC14	151613	broad.mit.edu	37	3	180328311	180328311	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr3:180328311G>T	uc003fkk.2	+	12	2426	c.2294G>T	c.(2293-2295)GGA>GTA	p.G765V	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	765							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAAGAAAAAGGAAATAAGTCA	0.303													17	36	---	---	---	---	PASS
POLN	353497	broad.mit.edu	37	4	2200252	2200252	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:2200252G>A	uc003ger.2	-	4	907	c.907C>T	c.(907-909)CGG>TGG	p.R303W	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Missense_Mutation_p.R303W	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	303					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			ATTTCTTACCGGGCAAATTGT	0.418								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					14	88	---	---	---	---	PASS
EVC2	132884	broad.mit.edu	37	4	5630349	5630349	+	Missense_Mutation	SNP	C	T	T	rs145693546	byFrequency	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:5630349C>T	uc003gij.2	-	12	1877	c.1823G>A	c.(1822-1824)CGT>CAT	p.R608H	EVC2_uc011bwb.1_Missense_Mutation_p.R48H|EVC2_uc003gik.2_Missense_Mutation_p.R528H	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	608						integral to membrane				large_intestine(3)|ovary(2)	5						GCCCTGCACACGGGTCTCTGA	0.498													12	70	---	---	---	---	PASS
SEPSECS	51091	broad.mit.edu	37	4	25146715	25146715	+	Nonsense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:25146715A>T	uc003grg.2	-	7	1058	c.845T>A	c.(844-846)TTG>TAG	p.L282*	SEPSECS_uc003gri.2_Nonsense_Mutation_p.L281*|SEPSECS_uc003grh.2_Nonsense_Mutation_p.L203*	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	282					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	ATTTTTGTCCAAGCTCTGAAC	0.353													36	43	---	---	---	---	PASS
TBC1D1	23216	broad.mit.edu	37	4	38047524	38047524	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:38047524A>G	uc003gtb.2	+	10	1972	c.1629A>G	c.(1627-1629)AAA>AAG	p.K543K	TBC1D1_uc011byd.1_Silent_p.K543K|TBC1D1_uc010ifd.2_Silent_p.K290K|TBC1D1_uc011byf.1_Silent_p.K414K	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	543						nucleus	Rab GTPase activator activity			ovary(1)	1						ACACCAGCAAAGTAAGCACAT	0.418													7	82	---	---	---	---	PASS
POLR2B	5431	broad.mit.edu	37	4	57873010	57873010	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:57873010C>T	uc003hcl.1	+	10	1289	c.1246C>T	c.(1246-1248)CGG>TGG	p.R416W	POLR2B_uc011cae.1_Missense_Mutation_p.R409W|POLR2B_uc011caf.1_Missense_Mutation_p.R341W|POLR2B_uc003hcm.1_5'Flank	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	416					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					TAAAGAAGTGCGGATCTATGC	0.333													11	87	---	---	---	---	PASS
AFP	174	broad.mit.edu	37	4	74306466	74306466	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:74306466C>G	uc003hgz.1	+	4	465	c.418C>G	c.(418-420)CAA>GAA	p.Q140E	AFP_uc003hha.1_Missense_Mutation_p.Q140E|AFP_uc011cbg.1_5'Flank	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	140	Albumin 1.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCCACTTTTCCAAGTTCCAGA	0.448									Alpha-Fetoprotein_Hereditary_Persistence_of				9	19	---	---	---	---	PASS
SHROOM3	57619	broad.mit.edu	37	4	77661990	77661990	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:77661990C>G	uc011cbx.1	+	5	3617	c.2664C>G	c.(2662-2664)AGC>AGG	p.S888R	SHROOM3_uc011cbz.1_Missense_Mutation_p.S712R|SHROOM3_uc003hkf.1_Missense_Mutation_p.S763R|SHROOM3_uc003hkg.2_Missense_Mutation_p.S666R	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	888					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TCCTCCGTAGCCAGAGCACCT	0.721													5	12	---	---	---	---	PASS
PLAC8	51316	broad.mit.edu	37	4	84028998	84028998	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:84028998C>A	uc003hoe.2	-	2	238	c.77G>T	c.(76-78)TGG>TTG	p.W26L	PLAC8_uc011cco.1_Missense_Mutation_p.W26L|PLAC8_uc010ijy.2_Intron|PLAC8_uc010ijz.2_Intron|PLAC8_uc003hod.2_Missense_Mutation_p.W26L	NM_001130716	NP_001124188	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	26										ovary(1)	1		Hepatocellular(203;0.114)				GCCTGTCTGCCAGTTGGAGTT	0.552													15	48	---	---	---	---	PASS
PDHA2	5161	broad.mit.edu	37	4	96761853	96761853	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:96761853C>T	uc003htr.3	+	1	615	c.552C>T	c.(550-552)AAC>AAT	p.N184N		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	184					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ATAAAGGAAACGATGAGATCT	0.483													6	55	---	---	---	---	PASS
BANK1	55024	broad.mit.edu	37	4	102992450	102992450	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:102992450A>G	uc003hvy.3	+	14	2505	c.2231A>G	c.(2230-2232)CAC>CGC	p.H744R	BANK1_uc003hvx.3_Missense_Mutation_p.H729R|BANK1_uc010ill.2_Missense_Mutation_p.H611R|BANK1_uc003hvz.3_Missense_Mutation_p.H714R	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	744					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		ACCATTGTGCACCATCCAGGT	0.294													48	95	---	---	---	---	PASS
COL25A1	84570	broad.mit.edu	37	4	109895698	109895698	+	Silent	SNP	T	C	C	rs142155024	by1000genomes	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:109895698T>C	uc003hze.1	-	6	987	c.456A>G	c.(454-456)AAA>AAG	p.K152K	COL25A1_uc003hzg.2_Silent_p.K152K|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	152	Extracellular (Potential).|Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCTTATCGCCTTTTGGACCAG	0.318													3	84	---	---	---	---	PASS
ANK2	287	broad.mit.edu	37	4	114274838	114274838	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:114274838G>C	uc003ibe.3	+	38	5164	c.5064G>C	c.(5062-5064)CAG>CAC	p.Q1688H	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.Q1703H	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1655					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATGAGACACAGAGTACACAGA	0.433													9	31	---	---	---	---	PASS
MFSD8	256471	broad.mit.edu	37	4	128851838	128851838	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:128851838T>A	uc003ifp.2	-	10	1161	c.998A>T	c.(997-999)AAG>ATG	p.K333M	MFSD8_uc011cgu.1_Missense_Mutation_p.K288M|MFSD8_uc011cgv.1_Missense_Mutation_p.K295I|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	333	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						CTTAACTTACTTTTTGGAAAG	0.313													15	93	---	---	---	---	PASS
F11	2160	broad.mit.edu	37	4	187201392	187201392	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr4:187201392C>A	uc003iza.1	+	9	1214	c.881C>A	c.(880-882)TCA>TAA	p.S294*		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	294	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	TGCCATTCTTCATTTTACCAT	0.517													34	88	---	---	---	---	PASS
AHRR	57491	broad.mit.edu	37	5	376726	376726	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:376726C>A	uc003jav.2	+	4	302	c.258C>A	c.(256-258)GTC>GTA	p.V86V	AHRR_uc003jaw.2_Silent_p.V82V|AHRR_uc010isy.2_Intron|AHRR_uc010isz.2_Silent_p.V82V	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CTCTGACAGTCGTGCAGGAGC	0.622													8	8	---	---	---	---	PASS
MARCH6	10299	broad.mit.edu	37	5	10410360	10410360	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:10410360G>T	uc003jet.1	+	18	1846	c.1663G>T	c.(1663-1665)GCG>TCG	p.A555S	MARCH6_uc011cmu.1_Missense_Mutation_p.A507S|MARCH6_uc003jeu.1_Missense_Mutation_p.A253S|MARCH6_uc011cmv.1_Missense_Mutation_p.A450S	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	555	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						GCTGGTGCGAGCGTGGACTGT	0.527													29	55	---	---	---	---	PASS
VCAN	1462	broad.mit.edu	37	5	82849313	82849313	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:82849313G>A	uc003kii.3	+	11	9980	c.9624G>A	c.(9622-9624)CTG>CTA	p.L3208L	VCAN_uc003kij.3_Silent_p.L2221L|VCAN_uc010jau.2_Silent_p.L1454L|VCAN_uc003kik.3_Silent_p.L467L|VCAN_uc003kil.3_Silent_p.L1872L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3208	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAAGCATCCTGTCTCACGAAG	0.458													24	38	---	---	---	---	PASS
PCDHB6	56130	broad.mit.edu	37	5	140531822	140531822	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:140531822G>T	uc003lir.2	+	1	1984	c.1984G>T	c.(1984-1986)GAC>TAC	p.D662Y	PCDHB6_uc011dah.1_Missense_Mutation_p.D526Y	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	662	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCTGGTGGACGGCTTCTC	0.692													28	35	---	---	---	---	PASS
DOCK2	1794	broad.mit.edu	37	5	169483700	169483700	+	Silent	SNP	C	A	A	rs141164963		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:169483700C>A	uc003maf.2	+	43	4388	c.4308C>A	c.(4306-4308)TCC>TCA	p.S1436S	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.S928S|DOCK2_uc003mah.2_5'UTR	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1436	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTACAAATCCAACTACGTGC	0.557													10	9	---	---	---	---	PASS
OR10C1	442194	broad.mit.edu	37	6	29407984	29407984	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr6:29407984C>A	uc011dlp.1	+	1	192	c.192C>A	c.(190-192)ACC>ACA	p.T64T	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTGCGCACCCTCTCGGCCT	0.577													16	42	---	---	---	---	PASS
ZNF292	23036	broad.mit.edu	37	6	87969574	87969574	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr6:87969574A>T	uc003plm.3	+	8	6268	c.6227A>T	c.(6226-6228)CAA>CTA	p.Q2076L		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2076					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACAAACACACAAACCAAAGGA	0.358													7	13	---	---	---	---	PASS
MDN1	23195	broad.mit.edu	37	6	90354761	90354761	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr6:90354761A>G	uc003pnn.1	-	101	16691	c.16575T>C	c.(16573-16575)TTT>TTC	p.F5525F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5525	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCAATACAACAAAGATGACAA	0.473													18	32	---	---	---	---	PASS
FUT9	10690	broad.mit.edu	37	6	96651407	96651407	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr6:96651407C>A	uc003pop.3	+	3	717	c.376C>A	c.(376-378)CCA>ACA	p.P126T		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	126	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GCAAGCTAGGCCACCCTTCCA	0.463													7	19	---	---	---	---	PASS
RFX6	222546	broad.mit.edu	37	6	117246809	117246809	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr6:117246809C>A	uc003pxm.2	+	16	1935	c.1872C>A	c.(1870-1872)AAC>AAA	p.N624K		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	624					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ACACAGACAACATGCCGCTCA	0.512													18	20	---	---	---	---	PASS
HDAC9	9734	broad.mit.edu	37	7	18788681	18788681	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:18788681A>T	uc003suh.2	+	13	1995	c.1954A>T	c.(1954-1956)ACC>TCC	p.T652S	HDAC9_uc003sue.2_Missense_Mutation_p.T652S|HDAC9_uc011jyd.1_Missense_Mutation_p.T652S|HDAC9_uc003sui.2_Missense_Mutation_p.T655S|HDAC9_uc003suj.2_Missense_Mutation_p.T611S|HDAC9_uc003sua.1_Missense_Mutation_p.T630S|HDAC9_uc010kue.1_Missense_Mutation_p.T307S	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	652	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGCAATTCCACCACCCACCC	0.453													7	14	---	---	---	---	PASS
PCLO	27445	broad.mit.edu	37	7	82763820	82763820	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:82763820G>A	uc003uhx.2	-	3	3335	c.3046C>T	c.(3046-3048)CCA>TCA	p.P1016S	PCLO_uc003uhv.2_Missense_Mutation_p.P1016S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	962	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTACTGTTGGAGCTTGTTCA	0.428													7	43	---	---	---	---	PASS
TFPI2	7980	broad.mit.edu	37	7	93516731	93516731	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:93516731C>T	uc003umy.1	-	4	548	c.473G>A	c.(472-474)TGC>TAC	p.C158Y	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Intron|TFPI2_uc003una.1_Missense_Mutation_p.C147Y|TFPI2_uc003unb.1_Missense_Mutation_p.C164Y|TFPI2_uc010lfg.1_Missense_Mutation_p.C34Y	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	158	BPTI/Kunitz inhibitor 3.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			TGGACTGTAGCAAAATGATGG	0.328													16	61	---	---	---	---	PASS
ZAN	7455	broad.mit.edu	37	7	100389747	100389747	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:100389747G>T	uc003uwj.2	+	42	7854	c.7689G>T	c.(7687-7689)ACG>ACT	p.T2563T	ZAN_uc003uwk.2_Silent_p.T2563T|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.R556L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2563	Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTCACCAGACGGTGGCCCCAG	0.652													8	29	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	7	100552594	100552594	+	RNA	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:100552594A>G	uc003uxk.1	+	1		c.1845A>G			uc003uxl.1_Missense_Mutation_p.S349G					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		CATGAAACCAAGCAGTAGCCT	0.572													4	190	---	---	---	---	PASS
MOGAT3	346606	broad.mit.edu	37	7	100841914	100841914	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:100841914C>G	uc003uyc.2	-	4	653	c.486G>C	c.(484-486)ATG>ATC	p.M162I	MOGAT3_uc010lhr.2_Missense_Mutation_p.M162I	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	162					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					CACCAAAGGACATGATGTAGT	0.627													5	53	---	---	---	---	PASS
MLL5	55904	broad.mit.edu	37	7	104702725	104702725	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:104702725G>T	uc003vcm.2	+	4	720	c.186G>T	c.(184-186)GCG>GCT	p.A62A	MLL5_uc010lja.1_5'UTR|MLL5_uc010ljb.1_Silent_p.A62A|MLL5_uc003vcl.2_Silent_p.A62A|MLL5_uc010ljc.2_Silent_p.A62A	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	62					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TGCCCTATGCGGTAAGTGTTA	0.383													30	180	---	---	---	---	PASS
PPP1R3A	5506	broad.mit.edu	37	7	113519831	113519831	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:113519831T>C	uc010ljy.1	-	4	1347	c.1316A>G	c.(1315-1317)GAT>GGT	p.D439G		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	439					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						AGCATTATCATCCAGGACTTC	0.413													31	143	---	---	---	---	PASS
KCND2	3751	broad.mit.edu	37	7	119915140	119915140	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:119915140G>T	uc003vjj.1	+	1	1419	c.454G>T	c.(454-456)GCG>TCG	p.A152S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	152	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCAGGACGACGCGGATACCGA	0.627													32	60	---	---	---	---	PASS
OR2F1	26211	broad.mit.edu	37	7	143657604	143657604	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr7:143657604C>A	uc003wds.1	+	1	585	c.541C>A	c.(541-543)CTC>ATC	p.L181I		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ATCCTGTGAACTCCTAGCTGT	0.502													24	33	---	---	---	---	PASS
BLK	640	broad.mit.edu	37	8	11420487	11420487	+	Splice_Site	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:11420487G>A	uc003wty.2	+	12	1762	c.1181_splice	c.e12-1	p.G394_splice	BLK_uc003wtz.2_Splice_Site_p.G323_splice|BLK_uc003wua.2_Splice_Site_p.G230_splice	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase						intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TTTTCCCACAGGGGCCAAGTT	0.612													7	19	---	---	---	---	PASS
C8orf79	57604	broad.mit.edu	37	8	12878990	12878990	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:12878990G>A	uc010lsq.2	+	5	1294	c.802G>A	c.(802-804)GTA>ATA	p.V268I	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.V181I|C8orf79_uc010lsr.2_Missense_Mutation_p.V142I	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	268							methyltransferase activity				0						AATTGAAAGAGTAAGACCCTT	0.413													8	24	---	---	---	---	PASS
ADAM32	203102	broad.mit.edu	37	8	39111935	39111935	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:39111935G>T	uc003xmt.3	+	18	2150	c.1905G>T	c.(1903-1905)GTG>GTT	p.V635V	ADAM32_uc011lch.1_Silent_p.V536V|ADAM32_uc003xmu.3_Silent_p.V529V|ADAM32_uc003xmv.2_Silent_p.V59V	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	635	EGF-like.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			GATCCTAGGTGTGTGATTCCA	0.353													3	11	---	---	---	---	PASS
ANK1	286	broad.mit.edu	37	8	41530104	41530104	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:41530104C>T	uc003xok.2	-	38	4948	c.4864G>A	c.(4864-4866)GAG>AAG	p.E1622K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.E1622K|ANK1_uc003xoj.2_Missense_Mutation_p.E1622K|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Missense_Mutation_p.E1663K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1622	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGTCGTCCTCCACAAGTTCC	0.557													23	152	---	---	---	---	PASS
POTEA	340441	broad.mit.edu	37	8	43157126	43157126	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:43157126A>G	uc003xpz.1	+	5	749	c.706A>G	c.(706-708)ATA>GTA	p.I236V	POTEA_uc003xqa.1_Intron	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	236	ANK 5.									ovary(1)	1						AACTGCCCTCATACTTGCTGT	0.323													41	66	---	---	---	---	PASS
TGS1	96764	broad.mit.edu	37	8	56699527	56699527	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:56699527G>T	uc003xsj.3	+	4	1457	c.1070G>T	c.(1069-1071)TGC>TTC	p.C357F	TGS1_uc010lyh.2_Missense_Mutation_p.C261F	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	357					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			AAAAGAGAGTGCCCTGCTTCC	0.443													21	30	---	---	---	---	PASS
LACTB2	51110	broad.mit.edu	37	8	71553256	71553256	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:71553256C>G	uc011lfd.1	-	5	714	c.622G>C	c.(622-624)GCT>CCT	p.A208P	LACTB2_uc003xyp.2_Missense_Mutation_p.A208P	NM_016027	NP_057111	Q53H82	LACB2_HUMAN	lactamase, beta 2	208							hydrolase activity|metal ion binding			ovary(1)	1	Breast(64;0.0716)		Epithelial(68;0.00319)|all cancers(69;0.0175)|OV - Ovarian serous cystadenocarcinoma(28;0.0628)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TGAATTTTAGCTTCAGCATTA	0.308													15	41	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77766728	77766728	+	Missense_Mutation	SNP	T	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:77766728T>G	uc003yav.2	+	10	7823	c.7436T>G	c.(7435-7437)CTT>CGT	p.L2479R	ZFHX4_uc003yau.1_Missense_Mutation_p.L2524R|ZFHX4_uc003yaw.1_Missense_Mutation_p.L2479R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2479						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACCAATTCCTTCACTCTCCG	0.498										HNSCC(33;0.089)			13	123	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139165236	139165236	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:139165236C>T	uc003yuy.2	-	13	1653	c.1482G>A	c.(1480-1482)ATG>ATA	p.M494I	FAM135B_uc003yux.2_Missense_Mutation_p.M395I|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.M56I|FAM135B_uc003yvb.2_Missense_Mutation_p.M56I	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	494										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATTCAGAGCACATGTCCATAT	0.418										HNSCC(54;0.14)			40	62	---	---	---	---	PASS
RHPN1	114822	broad.mit.edu	37	8	144463805	144463805	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr8:144463805C>A	uc003yyb.2	+	13	1685	c.1552C>A	c.(1552-1554)CGA>AGA	p.R518R		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	543	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCACCTGACCCGAGGAGAGGG	0.711													3	25	---	---	---	---	PASS
TMEM2	23670	broad.mit.edu	37	9	74305159	74305159	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr9:74305159T>C	uc011lsa.1	-	22	4240	c.3700A>G	c.(3700-3702)AAT>GAT	p.N1234D	TMEM2_uc011lrz.1_Missense_Mutation_p.N227D|TMEM2_uc010mos.2_Missense_Mutation_p.N1171D|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.N68D	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1234						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCAGTGCCATTGACCTGAGAA	0.478													14	17	---	---	---	---	PASS
SLC2A6	11182	broad.mit.edu	37	9	136338230	136338230	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr9:136338230C>A	uc004cee.2	-	9	1460	c.1365G>T	c.(1363-1365)GTG>GTT	p.V455V	SLC2A6_uc004cef.2_Silent_p.V393V|SLC2A6_uc004ceg.2_Silent_p.V432V	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	455	Helical; Name=11; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		CACTCACCACCACTGGCAGGA	0.682													3	16	---	---	---	---	PASS
FCN1	2219	broad.mit.edu	37	9	137808229	137808229	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr9:137808229C>T	uc004cfi.2	-	2	274	c.182G>A	c.(181-183)GGG>GAG	p.G61E		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	61	Collagen-like.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TCCCTTTGGCCCTGGGGCCCC	0.652													57	100	---	---	---	---	PASS
SFMBT2	57713	broad.mit.edu	37	10	7205784	7205784	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:7205784C>G	uc009xio.1	-	21	2724	c.2633G>C	c.(2632-2634)TGC>TCC	p.C878S	SFMBT2_uc001ijn.1_Missense_Mutation_p.C878S|SFMBT2_uc010qay.1_Missense_Mutation_p.C713S	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	878	SAM.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GATCTGGTGGCATAACTTGAT	0.567													5	26	---	---	---	---	PASS
ITGB1	3688	broad.mit.edu	37	10	33197297	33197297	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:33197297G>A	uc001iws.3	-	15	2466	c.2330C>T	c.(2329-2331)ACG>ATG	p.T777M	ITGB1_uc001iwp.3_Missense_Mutation_p.T777M|ITGB1_uc001iwq.3_Missense_Mutation_p.T777M|ITGB1_uc001iwr.3_Missense_Mutation_p.T777M|ITGB1_uc001iwt.3_Missense_Mutation_p.T777M|ITGB1_uc001iwu.1_Missense_Mutation_p.T777M	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	777	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				GTAACTTACCGTGTCCCATTT	0.348													26	62	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55566720	55566720	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:55566720G>T	uc010qhq.1	-	36	5063	c.4668C>A	c.(4666-4668)ACC>ACA	p.T1556T	PCDH15_uc010qhr.1_Silent_p.T1551T	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGGCACGGCGGGTTCTCACCA	0.478										HNSCC(58;0.16)			12	58	---	---	---	---	PASS
IFIT1	3434	broad.mit.edu	37	10	91162119	91162119	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:91162119C>T	uc001kgi.2	+	2	235	c.87C>T	c.(85-87)GAC>GAT	p.D29D	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|IFIT1_uc009xtt.2_Silent_p.D29D|IFIT1_uc001kgj.2_Translation_Start_Site	NM_001548	NP_001539	P09914	IFIT1_HUMAN	interferon-induced protein with	29					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding				0						CCATTGATGACGATGAAATGC	0.383													14	59	---	---	---	---	PASS
CYP2C19	1557	broad.mit.edu	37	10	96493185	96493185	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:96493185T>A	uc010qny.1	+	6	950	c.92T>A	c.(91-93)CTT>CAT	p.L31H	CYP2C18_uc001kjv.3_Silent_p.P427P|CYP2C18_uc001kjw.3_Silent_p.P368P|CYP2C19_uc009xus.1_Intron	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	Error:Variant_position_missing_in_P33261_after_alignment					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ACTTCATGCCTTTCTCAGCAG	0.433													27	44	---	---	---	---	PASS
LZTS2	84445	broad.mit.edu	37	10	102763912	102763912	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:102763912A>T	uc001ksj.2	+	3	1126	c.1057A>T	c.(1057-1059)ACC>TCC	p.T353S	LZTS2_uc010qpw.1_Missense_Mutation_p.T353S|LZTS2_uc001ksk.2_Missense_Mutation_p.T353S|LZTS2_uc001ksl.2_Missense_Mutation_p.T353S|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	353	Potential.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GAATGAGGCTACCATGTGCCA	0.597													5	18	---	---	---	---	PASS
DMBT1	1755	broad.mit.edu	37	10	124335935	124335935	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr10:124335935C>T	uc001lgk.1	+	7	410	c.304C>T	c.(304-306)CTG>TTG	p.L102L	DMBT1_uc001lgl.1_Silent_p.L102L|DMBT1_uc001lgm.1_Silent_p.L102L|DMBT1_uc009xzz.1_Silent_p.L102L|DMBT1_uc010qtx.1_Silent_p.L102L|DMBT1_uc009yaa.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	102	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGTTTGGCCCTGAGGCTGGT	0.557													35	66	---	---	---	---	PASS
OR52J3	119679	broad.mit.edu	37	11	5068517	5068517	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:5068517C>A	uc010qyv.1	+	1	762	c.762C>A	c.(760-762)ATC>ATA	p.I254I		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTTCTATATCCCTTCAGTCT	0.453													35	95	---	---	---	---	PASS
OR52J3	119679	broad.mit.edu	37	11	5068518	5068518	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:5068518C>A	uc010qyv.1	+	1	763	c.763C>A	c.(763-765)CCT>ACT	p.P255T		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTCTATATCCCTTCAGTCTT	0.453													35	92	---	---	---	---	PASS
OR52B6	340980	broad.mit.edu	37	11	5602557	5602557	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:5602557T>A	uc010qzi.1	+	1	451	c.451T>A	c.(451-453)TAT>AAT	p.Y151N	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	151	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCCCTGCGATATGTCACAAT	0.512													20	82	---	---	---	---	PASS
TRIM22	10346	broad.mit.edu	37	11	5719584	5719584	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:5719584T>A	uc001mbr.2	+	4	836	c.559T>A	c.(559-561)TTC>ATC	p.F187I	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Missense_Mutation_p.F155I|TRIM22_uc009yes.2_Missense_Mutation_p.F183I|TRIM22_uc010qzm.1_Intron|TRIM22_uc009yeu.2_5'UTR	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	187	Potential.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TCTGAAAGGGTTCAATGAAAT	0.463													3	26	---	---	---	---	PASS
OR56A3	390083	broad.mit.edu	37	11	5968711	5968711	+	Silent	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:5968711C>G	uc010qzt.1	+	1	135	c.135C>G	c.(133-135)GCC>GCG	p.A45A		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCGTAGGGGCCAACACCACCC	0.597													25	64	---	---	---	---	PASS
FOLH1	2346	broad.mit.edu	37	11	49175797	49175797	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:49175797G>T	uc001ngy.2	-	16	2132	c.1871C>A	c.(1870-1872)ACA>AAA	p.T624K	FOLH1_uc001ngx.2_Missense_Mutation_p.T56K|FOLH1_uc001ngz.2_Missense_Mutation_p.T624K|FOLH1_uc009yly.2_Missense_Mutation_p.T609K|FOLH1_uc009ylz.2_Missense_Mutation_p.T609K|FOLH1_uc009yma.2_Missense_Mutation_p.T316K	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	624	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TACACTGTATGTCTTCATTTC	0.333													9	68	---	---	---	---	PASS
OR4S2	219431	broad.mit.edu	37	11	55419293	55419293	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:55419293T>A	uc001nhs.1	+	1	914	c.914T>A	c.(913-915)TTC>TAC	p.F305Y		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				AGAAATGTTTTCTTGGAGGCT	0.264													29	103	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55432917	55432917	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:55432917T>C	uc001nht.3	+	3	540	c.275T>C	c.(274-276)CTC>CCC	p.L92P	OR4C6_uc010rik.1_Missense_Mutation_p.L92P	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						ACCATCTCTCTCAAAGGCTGC	0.502													13	38	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55432918	55432918	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:55432918C>A	uc001nht.3	+	3	541	c.276C>A	c.(274-276)CTC>CTA	p.L92L	OR4C6_uc010rik.1_Silent_p.L92L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CCATCTCTCTCAAAGGCTGCC	0.502													13	37	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55432933	55432933	+	Silent	SNP	C	A	A	rs77687368	byFrequency	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:55432933C>A	uc001nht.3	+	3	556	c.291C>A	c.(289-291)ACC>ACA	p.T97T	OR4C6_uc010rik.1_Silent_p.T97T	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTGCCTCACCCAGCTGTTTG	0.527													15	36	---	---	---	---	PASS
OR5W2	390148	broad.mit.edu	37	11	55681789	55681789	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:55681789C>G	uc010rir.1	-	1	270	c.270G>C	c.(268-270)AAG>AAC	p.K90N		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGGGTATTGACTTGTTCTTGG	0.448													16	35	---	---	---	---	PASS
OR8K3	219473	broad.mit.edu	37	11	56086487	56086487	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:56086487G>T	uc010rjf.1	+	1	705	c.705G>T	c.(703-705)AAG>AAT	p.K235N		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GCAGACAAAAGGCTTTTTCTA	0.433													16	38	---	---	---	---	PASS
OR8K1	390157	broad.mit.edu	37	11	56113662	56113662	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:56113662G>T	uc010rjg.1	+	1	148	c.148G>T	c.(148-150)GGC>TGC	p.G50C		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGGCAATCTGGGCATGGTTAT	0.448										HNSCC(65;0.19)			10	68	---	---	---	---	PASS
TMEM132A	54972	broad.mit.edu	37	11	60696322	60696322	+	Silent	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:60696322G>T	uc001nqj.2	+	4	949	c.756G>T	c.(754-756)CTG>CTT	p.L252L	TMEM132A_uc001nqi.2_Silent_p.L252L|TMEM132A_uc001nqk.2_Silent_p.L265L|TMEM132A_uc001nql.1_Silent_p.L265L	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	252	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						AGGTACCTCTGGACGAGGCTG	0.677													9	24	---	---	---	---	PASS
AHNAK	79026	broad.mit.edu	37	11	62298384	62298384	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:62298384C>A	uc001ntl.2	-	5	3805	c.3505G>T	c.(3505-3507)GTG>TTG	p.V1169L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1169					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCGAGGCTCACATCTGGGGCT	0.542													30	143	---	---	---	---	PASS
CFL1	1072	broad.mit.edu	37	11	65623490	65623490	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:65623490G>A	uc001ofs.2	-	2	461	c.227C>T	c.(226-228)CCA>CTA	p.P76L	CFL1_uc001oft.2_Missense_Mutation_p.P76L|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	76	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		GTCCTTATCTGGCAGCATCTT	0.537													12	92	---	---	---	---	PASS
RSF1	51773	broad.mit.edu	37	11	77412453	77412453	+	Silent	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:77412453T>C	uc001oyn.2	-	6	1941	c.1821A>G	c.(1819-1821)CCA>CCG	p.P607P	RSF1_uc001oym.2_Silent_p.P355P	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	607					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			GAACTTCTTCTGGTATTGGAC	0.423													49	76	---	---	---	---	PASS
FAM55D	54827	broad.mit.edu	37	11	114441738	114441738	+	Silent	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:114441738T>C	uc001ppc.2	-	6	1738	c.1557A>G	c.(1555-1557)GCA>GCG	p.A519A	FAM55D_uc001ppd.2_Silent_p.A235A	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	519						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		TTGTGCCATATGCAATTGTTA	0.313													28	47	---	---	---	---	PASS
ZNF202	7753	broad.mit.edu	37	11	123599838	123599838	+	Nonsense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:123599838G>C	uc001pzd.1	-	6	1098	c.698C>G	c.(697-699)TCA>TGA	p.S233*	ZNF202_uc001pzc.1_Nonsense_Mutation_p.S9*|ZNF202_uc001pze.1_Nonsense_Mutation_p.S233*|ZNF202_uc001pzf.1_Nonsense_Mutation_p.S233*	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	233					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GCACACCTGTGACAGAGCAGT	0.493													7	9	---	---	---	---	PASS
OR8A1	390275	broad.mit.edu	37	11	124440091	124440091	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr11:124440091C>A	uc010san.1	+	1	127	c.127C>A	c.(127-129)CCC>ACC	p.P43T		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	43	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCTCCAGCTCCCCCTCTTTCT	0.532													16	30	---	---	---	---	PASS
WNK1	65125	broad.mit.edu	37	12	990939	990939	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:990939G>A	uc001qio.3	+	13	3700	c.3193G>A	c.(3193-3195)GCT>ACT	p.A1065T	WNK1_uc001qip.3_Missense_Mutation_p.A818T|WNK1_uc001qir.3_Missense_Mutation_p.A238T	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1065					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GACCACTTTGGCTTCCTCTGT	0.458													16	54	---	---	---	---	PASS
GDF3	9573	broad.mit.edu	37	12	7848323	7848323	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:7848323A>G	uc001qte.2	-	1	38	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	1					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GAAACGAAGCATGGCCTCTGG	0.478													3	15	---	---	---	---	PASS
ANO6	196527	broad.mit.edu	37	12	45823018	45823018	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:45823018T>C	uc001roo.2	+	20	2992	c.2657T>C	c.(2656-2658)ATG>ACG	p.M886T	ANO6_uc010sld.1_Intron|ANO6_uc010sle.1_Intron|ANO6_uc010slf.1_Missense_Mutation_p.M907T|ANO6_uc010slg.1_Missense_Mutation_p.M868T	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	886	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						CTCAAAGATATGACGAAAAAT	0.388													12	21	---	---	---	---	PASS
SFRS2IP	9169	broad.mit.edu	37	12	46320550	46320550	+	Silent	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:46320550T>C	uc001rox.2	-	11	3221	c.2934A>G	c.(2932-2934)CCA>CCG	p.P978P	SFRS2IP_uc001row.2_Silent_p.P663P|SFRS2IP_uc001roy.1_Silent_p.P1052P	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	978	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTTCCTCGTGGACATCTCC	0.388													49	127	---	---	---	---	PASS
VDR	7421	broad.mit.edu	37	12	48249545	48249545	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:48249545C>A	uc001rqm.2	-	8	905	c.623G>T	c.(622-624)AGT>ATT	p.S208I	VDR_uc001rql.2_Missense_Mutation_p.S258I|VDR_uc001rqn.2_Missense_Mutation_p.S208I|VDR_uc010slq.1_Missense_Mutation_p.S176I	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	208	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ATCTTCTTCACTCAGATCCAG	0.532													10	29	---	---	---	---	PASS
TFCP2	7024	broad.mit.edu	37	12	51504759	51504759	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:51504759C>A	uc001rxw.2	-	5	924	c.465G>T	c.(463-465)CCG>CCT	p.P155P	TFCP2_uc001rxv.1_Silent_p.P155P|TFCP2_uc009zlx.1_Silent_p.P155P|TFCP2_uc001rxx.2_Silent_p.P155P|TFCP2_uc009zly.1_Silent_p.P57P	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	155	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCACAGACATCGGGATATCTG	0.388													22	83	---	---	---	---	PASS
EIF4B	1975	broad.mit.edu	37	12	53428431	53428431	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:53428431G>T	uc001sbh.3	+	10	1450	c.1244G>T	c.(1243-1245)CGG>CTG	p.R415L	EIF4B_uc010snu.1_Missense_Mutation_p.R415L|EIF4B_uc010snv.1_Missense_Mutation_p.R376L|EIF4B_uc001sbi.2_Missense_Mutation_p.R167L	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	415					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						ACTCAGGAACGGGAACGGTCG	0.507													8	49	---	---	---	---	PASS
C12orf63	374467	broad.mit.edu	37	12	97137324	97137324	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:97137324T>C	uc001tet.1	+	20	2717	c.2639T>C	c.(2638-2640)ATG>ACG	p.M880T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	880										skin(6)|ovary(1)	7						GCAGACATCATGACAAACCTT	0.423													6	30	---	---	---	---	PASS
OAS3	4940	broad.mit.edu	37	12	113388514	113388514	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:113388514G>A	uc001tug.2	+	7	1478	c.1391G>A	c.(1390-1392)CGG>CAG	p.R464Q		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	464	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TCATTTGGCCGGGGCACAGAC	0.592													9	113	---	---	---	---	PASS
ABCB9	23457	broad.mit.edu	37	12	123419863	123419863	+	Missense_Mutation	SNP	T	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:123419863T>C	uc001udm.3	-	10	2169	c.1859A>G	c.(1858-1860)AAT>AGT	p.N620S	ABCB9_uc010tai.1_Missense_Mutation_p.N227S|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.N577S|ABCB9_uc010taj.1_Missense_Mutation_p.N557S|ABCB9_uc001udp.2_Missense_Mutation_p.N620S|ABCB9_uc001udq.2_Missense_Mutation_p.N339S	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	620	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GCCGTGGGCATTGGCCTTCTG	0.637													5	21	---	---	---	---	PASS
TMEM132B	114795	broad.mit.edu	37	12	126004126	126004126	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:126004126C>A	uc001uhe.1	+	4	1241	c.1233C>A	c.(1231-1233)ATC>ATA	p.I411I		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	411	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCTCCGAGATCTTCGTCAGCC	0.517													4	52	---	---	---	---	PASS
RIMBP2	23504	broad.mit.edu	37	12	130922965	130922965	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr12:130922965C>A	uc001uil.2	-	9	1714	c.1550G>T	c.(1549-1551)GGG>GTG	p.G517V	RIMBP2_uc001uim.2_Missense_Mutation_p.G425V|RIMBP2_uc001uin.1_Missense_Mutation_p.G176V	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	517	Fibronectin type-III 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ATTGGACAGCCCGGTGGGCGT	0.637													6	17	---	---	---	---	PASS
MTMR6	9107	broad.mit.edu	37	13	25841966	25841966	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr13:25841966T>A	uc001uqf.3	-	3	574	c.255A>T	c.(253-255)GAA>GAT	p.E85D	MTMR6_uc001uqe.1_Missense_Mutation_p.E85D	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	85						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GGCAATCTCTTTCTCTGGGAA	0.393													9	44	---	---	---	---	PASS
SLITRK1	114798	broad.mit.edu	37	13	84453702	84453702	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr13:84453702C>A	uc001vlk.2	-	1	2827	c.1941G>T	c.(1939-1941)AAG>AAT	p.K647N		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	647	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCTTGGACCGCTTTCGGTTCC	0.567													9	16	---	---	---	---	PASS
MYO16	23026	broad.mit.edu	37	13	109707450	109707450	+	Silent	SNP	A	G	G	rs143387670		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr13:109707450A>G	uc001vqt.1	+	26	3165	c.3039A>G	c.(3037-3039)CCA>CCG	p.P1013P	MYO16_uc010agk.1_Silent_p.P1035P|MYO16_uc001vqu.1_Silent_p.P813P|MYO16_uc010tjh.1_Silent_p.P525P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1013	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GAGGAGATCCAGTCACCATAG	0.328													15	20	---	---	---	---	PASS
C14orf93	60686	broad.mit.edu	37	14	23465159	23465159	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:23465159A>G	uc001wib.1	-	3	1226	c.916T>C	c.(916-918)TCT>CCT	p.S306P	C14orf93_uc001wic.1_Missense_Mutation_p.S126P|C14orf93_uc001wid.1_Missense_Mutation_p.S306P|C14orf93_uc001wig.2_Missense_Mutation_p.S306P|C14orf93_uc001wih.2_Missense_Mutation_p.S306P|C14orf93_uc001wie.2_Missense_Mutation_p.S306P|C14orf93_uc001wia.3_Missense_Mutation_p.S306P|C14orf93_uc001wif.2_Missense_Mutation_p.S126P	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	306						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		TCACTCACAGAGAGTACAAGA	0.493													5	80	---	---	---	---	PASS
CEBPE	1053	broad.mit.edu	37	14	23588252	23588252	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:23588252G>A	uc001wiv.1	-	1	223	c.49C>T	c.(49-51)CCA>TCA	p.P17S		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	17						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		AACTCGAGTGGCTGCTGGCCA	0.692													3	29	---	---	---	---	PASS
LRFN5	145581	broad.mit.edu	37	14	42356142	42356142	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:42356142A>G	uc001wvm.2	+	3	1512	c.314A>G	c.(313-315)CAT>CGT	p.H105R	LRFN5_uc010ana.2_Missense_Mutation_p.H105R	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	105	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGGGCTTTGCATTTGAATAGC	0.368										HNSCC(30;0.082)			18	59	---	---	---	---	PASS
C14orf135	64430	broad.mit.edu	37	14	60582115	60582115	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:60582115A>G	uc001xer.3	+	3	1113	c.591A>G	c.(589-591)GTA>GTG	p.V197V	C14orf135_uc001xeq.2_Silent_p.V197V|C14orf135_uc010apm.2_5'Flank	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	431						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		CTGTGACTGTATTCTTTGAGA	0.343													39	118	---	---	---	---	PASS
ALDH6A1	4329	broad.mit.edu	37	14	74538983	74538983	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:74538983G>T	uc001xpo.2	-	4	370	c.271C>A	c.(271-273)CCT>ACT	p.P91T	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_5'UTR|ALDH6A1_uc010tuq.1_Missense_Mutation_p.P91T	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	91						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GCCCATGCAGGAAAAGCACGT	0.463													14	28	---	---	---	---	PASS
SERPINA3	12	broad.mit.edu	37	14	95081268	95081268	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:95081268G>C	uc001ydp.2	+	2	569	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	SERPINA3_uc001ydo.3_Missense_Mutation_p.E189Q|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.E164Q|SERPINA3_uc001yds.2_Missense_Mutation_p.E164Q|SERPINA3_uc010avg.2_Missense_Mutation_p.E164Q	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	164					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GTATGGCTCCGAGGCCTTTGC	0.502													9	42	---	---	---	---	PASS
DICER1	23405	broad.mit.edu	37	14	95562709	95562709	+	Missense_Mutation	SNP	T	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:95562709T>A	uc001ydw.2	-	24	4730	c.4548A>T	c.(4546-4548)AAA>AAT	p.K1516N	DICER1_uc010avh.1_Missense_Mutation_p.K414N|DICER1_uc001ydv.2_Missense_Mutation_p.K1506N|DICER1_uc001ydx.2_Missense_Mutation_p.K1516N|DICER1_uc001ydy.1_Missense_Mutation_p.K368N	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1516					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CTTCAACAGCTTTGCTAGGAT	0.433			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				32	64	---	---	---	---	PASS
AHNAK2	113146	broad.mit.edu	37	14	105415577	105415577	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr14:105415577G>C	uc010axc.1	-	7	6331	c.6211C>G	c.(6211-6213)CTG>GTG	p.L2071V	AHNAK2_uc001ypx.2_Missense_Mutation_p.L1971V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2071						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACCTTGGGCAGGTGCCCTTTG	0.617													77	42	---	---	---	---	PASS
TRPM1	4308	broad.mit.edu	37	15	31330029	31330029	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr15:31330029G>T	uc001zfm.2	-	19	2518	c.2390C>A	c.(2389-2391)GCT>GAT	p.A797D	TRPM1_uc010azy.2_Missense_Mutation_p.A704D|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	797	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCTTGAGCCAGCATCTGCATT	0.478													8	20	---	---	---	---	PASS
UACA	55075	broad.mit.edu	37	15	70960257	70960257	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr15:70960257G>A	uc002asr.2	-	16	2870	c.2766C>T	c.(2764-2766)TAC>TAT	p.Y922Y	UACA_uc010uke.1_Silent_p.Y813Y|UACA_uc002asq.2_Silent_p.Y909Y|UACA_uc010bin.1_Silent_p.Y897Y	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	922	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CCAGGCTGATGTACTCAGCTT	0.363													13	41	---	---	---	---	PASS
RASGRF1	5923	broad.mit.edu	37	15	79356805	79356805	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr15:79356805C>A	uc002beq.2	-	2	715	c.340G>T	c.(340-342)GCA>TCA	p.A114S	RASGRF1_uc002bep.2_Missense_Mutation_p.A114S|RASGRF1_uc010blm.1_Missense_Mutation_p.A36S|RASGRF1_uc002ber.3_Missense_Mutation_p.A114S	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	114	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CAATCTTTTGCGTCCTCTGTC	0.512													27	123	---	---	---	---	PASS
PRC1	9055	broad.mit.edu	37	15	91513658	91513658	+	Silent	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr15:91513658A>T	uc002bqm.2	-	12	1705	c.1548T>A	c.(1546-1548)TCT>TCA	p.S516S	PRC1_uc002bqn.2_Silent_p.S516S|PRC1_uc002bqo.2_Silent_p.S516S|PRC1_uc010uqs.1_Silent_p.S475S	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	516	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GAGGAAGTCGAGACACGGGGG	0.542													28	106	---	---	---	---	PASS
ABAT	18	broad.mit.edu	37	16	8829667	8829667	+	Splice_Site	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:8829667G>T	uc002czc.3	+	2	236	c.70_splice	c.e2+1	p.G24_splice	ABAT_uc002czd.3_Splice_Site_p.G24_splice|ABAT_uc010buh.2_Splice_Site|ABAT_uc010bui.2_Splice_Site_p.G24_splice	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor						behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CTGGTGCCTGGTAAGCCCCGG	0.597													4	11	---	---	---	---	PASS
CPPED1	55313	broad.mit.edu	37	16	12758835	12758835	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:12758835C>T	uc002dca.3	-	4	964	c.853G>A	c.(853-855)GCC>ACC	p.A285T	CPPED1_uc002dcb.3_Missense_Mutation_p.A143T|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	285							hydrolase activity|metal ion binding				0						ATTTTCTCGGCGGTGACCACC	0.522													9	57	---	---	---	---	PASS
DNAH3	55567	broad.mit.edu	37	16	21082070	21082070	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:21082070A>G	uc010vbe.1	-	22	3162	c.3162T>C	c.(3160-3162)TGT>TGC	p.C1054C		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1054	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATGGGGAGCCACACATGGTCT	0.433													14	72	---	---	---	---	PASS
TNRC6A	27327	broad.mit.edu	37	16	24788444	24788444	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:24788444G>T	uc002dmm.2	+	5	468	c.354G>T	c.(352-354)CAG>CAT	p.Q118H	TNRC6A_uc010bxs.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	118	Gln-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		cgcagccgcagcagcagcagc	0.254													9	24	---	---	---	---	PASS
NOB1	28987	broad.mit.edu	37	16	69782934	69782934	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:69782934C>A	uc002exs.2	-	6	629	c.613G>T	c.(613-615)GGG>TGG	p.G205W		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	205						nucleus	metal ion binding|protein binding				0						CAGCCACCCCCGTCGTCATCG	0.552													10	18	---	---	---	---	PASS
BCAR1	9564	broad.mit.edu	37	16	75263738	75263738	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:75263738C>A	uc002fdv.2	-	7	2407	c.2284G>T	c.(2284-2286)GTG>TTG	p.V762L	BCAR1_uc002fdt.2_Missense_Mutation_p.V215L|BCAR1_uc002fdu.2_Missense_Mutation_p.V552L|BCAR1_uc010cgu.2_Missense_Mutation_p.V751L|BCAR1_uc010vna.1_Missense_Mutation_p.V760L|BCAR1_uc010vnb.1_Missense_Mutation_p.V808L|BCAR1_uc002fdw.2_Missense_Mutation_p.V762L|BCAR1_uc010vnc.1_Missense_Mutation_p.V614L|BCAR1_uc010vnd.1_Missense_Mutation_p.V780L|BCAR1_uc002fdx.2_Missense_Mutation_p.V780L	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	762	Divergent helix-loop-helix motif.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAGGCGTCCACGGCGTTGGTC	0.647													16	46	---	---	---	---	PASS
CLEC3A	10143	broad.mit.edu	37	16	78064380	78064380	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:78064380A>T	uc002ffh.3	+	3	317	c.236A>T	c.(235-237)TAC>TTC	p.Y79F		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	79	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						AAGAAATGCTACCTTGCTTCA	0.433													9	68	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	16	88620366	88620366	+	Silent	SNP	G	A	A	rs149492586	byFrequency	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:88620366G>A	uc010vox.1	-	2	264	c.264C>T	c.(262-264)GTC>GTT	p.V88V						RecName: Full=Putative uncharacterized protein C16orf85;																		AGCTGGGACGGACGCCCGCAG	0.662													7	52	---	---	---	---	PASS
TCF25	22980	broad.mit.edu	37	16	89950999	89950999	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:89950999A>G	uc002fpb.2	+	3	446	c.364A>G	c.(364-366)AGT>GGT	p.S122G	TCF25_uc002fpc.2_5'UTR	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	122					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		GTCTCATGCAAGTGGCAAACT	0.438													5	9	---	---	---	---	PASS
ZNF594	84622	broad.mit.edu	37	17	5086085	5086085	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:5086085C>A	uc010cla.1	-	2	1623	c.1467G>T	c.(1465-1467)CAG>CAT	p.Q489H		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	489	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						ATTCAGTGCACTGATAGGGCT	0.458													21	29	---	---	---	---	PASS
ACAP1	9744	broad.mit.edu	37	17	7253320	7253320	+	Silent	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:7253320G>C	uc002ggd.2	+	19	2114	c.1908G>C	c.(1906-1908)GCG>GCC	p.A636A	KCTD11_uc002gge.3_5'Flank	NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	636	Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						TGAACCAAGCGGACAGTGCGG	0.622													11	99	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	A	A	rs121912660		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:7577099C>A	uc002gim.2	-	8	1033	c.839G>T	c.(838-840)AGA>ATA	p.R280I	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148I|TP53_uc010cng.1_Missense_Mutation_p.R148I|TP53_uc002gii.1_Missense_Mutation_p.R148I|TP53_uc010cnh.1_Missense_Mutation_p.R280I|TP53_uc010cni.1_Missense_Mutation_p.R280I|TP53_uc002gij.2_Missense_Mutation_p.R280I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	20	---	---	---	---	PASS
LIMD2	80774	broad.mit.edu	37	17	61776255	61776255	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:61776255C>T	uc002jbj.3	-	4	306	c.128G>A	c.(127-129)TGC>TAC	p.C43Y	LIMD2_uc002jbk.3_Silent_p.L44L|LIMD2_uc002jbl.3_Missense_Mutation_p.C43Y	NM_030576	NP_085053	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	43	LIM zinc-binding.						zinc ion binding				0						GGTCTTCTGGCAGGCGGCGCA	0.632													19	64	---	---	---	---	PASS
SCN4A	6329	broad.mit.edu	37	17	62018275	62018275	+	Silent	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:62018275C>A	uc002jds.1	-	24	5444	c.5367G>T	c.(5365-5367)TCG>TCT	p.S1789S		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1789					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CCGGGCTTGGCGAGCTGCTGT	0.667													19	41	---	---	---	---	PASS
LRRC37A3	374819	broad.mit.edu	37	17	62856410	62856410	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:62856410G>A	uc002jey.2	-	11	4385	c.3854C>T	c.(3853-3855)GCA>GTA	p.A1285V	LRRC37A3_uc010wqg.1_Missense_Mutation_p.A403V|LRRC37A3_uc002jex.1_Missense_Mutation_p.A262V|LRRC37A3_uc010wqf.1_Missense_Mutation_p.A323V|LRRC37A3_uc010dek.1_Missense_Mutation_p.A291V	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1285	Extracellular (Potential).					integral to membrane					0						TCTAGCCTTTGCACTTTCTAA	0.463													12	184	---	---	---	---	PASS
SLC16A6	9120	broad.mit.edu	37	17	66267094	66267094	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:66267094G>T	uc002jgz.1	-	5	1395	c.1207C>A	c.(1207-1209)CAC>AAC	p.H403N	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Missense_Mutation_p.H403N	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	403	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	AGTGGAATGTGAGTCCCTCCT	0.463													32	50	---	---	---	---	PASS
DNAI2	64446	broad.mit.edu	37	17	72305467	72305467	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:72305467C>T	uc002jkf.2	+	10	1386	c.1287C>T	c.(1285-1287)GAC>GAT	p.D429D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_Missense_Mutation_p.V90I|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	429	WD 5.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CCAGGATGGACGGAACCCTGG	0.577									Kartagener_syndrome				4	34	---	---	---	---	PASS
LLGL2	3993	broad.mit.edu	37	17	73569291	73569291	+	Missense_Mutation	SNP	G	A	A	rs139000321		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:73569291G>A	uc002joh.2	+	20	2811	c.2657G>A	c.(2656-2658)CGC>CAC	p.R886H	LLGL2_uc002joi.2_Missense_Mutation_p.R886H|LLGL2_uc010dgg.1_Missense_Mutation_p.R886H|LLGL2_uc002joj.2_Missense_Mutation_p.R875H|LLGL2_uc010wsd.1_Missense_Mutation_p.R513H	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	886	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CCCCAGGTGCGCTACAGCTGC	0.652													32	81	---	---	---	---	PASS
CBX4	8535	broad.mit.edu	37	17	77808067	77808067	+	Silent	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr17:77808067C>G	uc002jxe.2	-	5	1537	c.1374G>C	c.(1372-1374)CCG>CCC	p.P458P		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	458	Interaction with BMI1.			P -> R (in Ref. 1; AAB80718 and 4; AAB62734).	anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCTCGGGCTGCGGGAGGGCGG	0.716													4	18	---	---	---	---	PASS
FAM59A	64762	broad.mit.edu	37	18	29848010	29848010	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr18:29848010A>C	uc002kxl.2	-	6	2511	c.2455T>G	c.(2455-2457)TCA>GCA	p.S819A	FAM59A_uc002kxk.1_Missense_Mutation_p.S818A	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	819	SAM.									ovary(1)|skin(1)	2						AACCGTAGTGACTTGGACACT	0.502													42	34	---	---	---	---	PASS
TCEB3B	51224	broad.mit.edu	37	18	44560338	44560338	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr18:44560338A>T	uc002lcr.1	-	1	1651	c.1298T>A	c.(1297-1299)GTC>GAC	p.V433D	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	433					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GCTTTCCTGGACAGGAGGCAA	0.567													171	76	---	---	---	---	PASS
MBD1	4152	broad.mit.edu	37	18	47801500	47801500	+	Missense_Mutation	SNP	G	A	A	rs115426299	by1000genomes	TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr18:47801500G>A	uc010dow.1	-	9	1345	c.908C>T	c.(907-909)CCG>CTG	p.P303L	MBD1_uc002lef.2_Missense_Mutation_p.P110L|MBD1_uc002leg.2_Missense_Mutation_p.P254L|MBD1_uc010xdi.1_Missense_Mutation_p.P354L|MBD1_uc002leh.3_Missense_Mutation_p.P303L|MBD1_uc002len.2_Missense_Mutation_p.P303L|MBD1_uc002lei.3_Missense_Mutation_p.P303L|MBD1_uc002lej.3_Missense_Mutation_p.P303L|MBD1_uc002lek.3_Missense_Mutation_p.P254L|MBD1_uc002lel.3_Missense_Mutation_p.P303L|MBD1_uc002lem.3_Missense_Mutation_p.P303L|MBD1_uc010xdj.1_Missense_Mutation_p.P303L|MBD1_uc010xdk.1_Missense_Mutation_p.P328L|MBD1_uc010dox.1_Missense_Mutation_p.P303L|MBD1_uc002leo.2_Missense_Mutation_p.P303L	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	303	Pro-rich.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGGCCTCACCGGCTCTGTGGG	0.677													13	42	---	---	---	---	PASS
ST8SIA3	51046	broad.mit.edu	37	18	55027340	55027340	+	Silent	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr18:55027340A>G	uc002lgn.2	+	4	1332	c.975A>G	c.(973-975)GGA>GGG	p.G325G		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	325	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GGCCGTTTGGATTTGACCCCA	0.448													15	45	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9073731	9073731	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:9073731G>T	uc002mkp.2	-	3	13919	c.13715C>A	c.(13714-13716)TCC>TAC	p.S4572Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4574	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCCATGCTGGAGGCAGGAAC	0.522													12	20	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9083825	9083825	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:9083825A>C	uc002mkp.2	-	1	8194	c.7990T>G	c.(7990-7992)TCC>GCC	p.S2664A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2664	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAATCAAAGGATGTAGCTAAT	0.517													11	14	---	---	---	---	PASS
MAP1S	55201	broad.mit.edu	37	19	17835910	17835910	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:17835910G>T	uc002nhe.1	+	4	365	c.356G>T	c.(355-357)GGG>GTG	p.G119V	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Missense_Mutation_p.G119V|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.G93V	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	119	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GTGTTGGCTGGGCCCTGCCTG	0.612													25	48	---	---	---	---	PASS
CRTC1	23373	broad.mit.edu	37	19	18876308	18876308	+	Silent	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:18876308C>G	uc002nkb.3	+	9	1069	c.981C>G	c.(979-981)CCC>CCG	p.P327P	CRTC1_uc010ebv.2_Silent_p.P343P|CRTC1_uc010ebw.2_Silent_p.P192P|CRTC1_uc002nkc.3_Silent_p.P192P	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	327	Ser-rich.				interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						AGGCATCGCCCACCCTGTCCC	0.657													9	130	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22155467	22155467	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:22155467G>T	uc002nqp.2	-	5	2218	c.2069C>A	c.(2068-2070)GCA>GAA	p.A690E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AATAAGGATTGCAGATCGGTT	0.363													20	51	---	---	---	---	PASS
ZNF257	113835	broad.mit.edu	37	19	22271749	22271749	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:22271749C>T	uc010ecx.2	+	4	1366	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	ZNF257_uc010ecy.2_Silent_p.A367A	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAGAGAAGGCCTACAAATGTG	0.373													6	31	---	---	---	---	PASS
ZNF254	9534	broad.mit.edu	37	19	24309770	24309770	+	Missense_Mutation	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:24309770A>T	uc002nru.2	+	4	1102	c.968A>T	c.(967-969)AAG>ATG	p.K323M	ZNF254_uc010xrk.1_Missense_Mutation_p.K238M	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	323	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AAACCCTACAAGTGTGAAGAA	0.403													29	44	---	---	---	---	PASS
FFAR2	2867	broad.mit.edu	37	19	35941175	35941175	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:35941175C>A	uc002nzg.2	+	2	639	c.559C>A	c.(559-561)CTC>ATC	p.L187I	FFAR2_uc010eea.2_Missense_Mutation_p.L187I	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	187	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GTGCCTGGTGCTCTTCTTCAT	0.587													6	113	---	---	---	---	PASS
MLL4	9757	broad.mit.edu	37	19	36213498	36213498	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:36213498G>A	uc010eei.2	+	5	2600	c.2600G>A	c.(2599-2601)CGC>CAC	p.R867H		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	867					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAAGGTCCCCGCATCAAACAT	0.657													3	9	---	---	---	---	PASS
ZNF568	374900	broad.mit.edu	37	19	37427735	37427735	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:37427735G>A	uc002ofc.2	+	5	738	c.223G>A	c.(223-225)GAT>AAT	p.D75N	ZNF568_uc010efg.2_Missense_Mutation_p.D61N|ZNF568_uc010xtn.1_5'UTR|ZNF568_uc002ofd.2_5'UTR|ZNF568_uc010efe.2_5'UTR|ZNF568_uc010eff.1_Missense_Mutation_p.D61N	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTGTATCGAGATGTGATGCT	0.423													4	57	---	---	---	---	PASS
RYR1	6261	broad.mit.edu	37	19	39063910	39063910	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:39063910G>T	uc002oit.2	+	96	14222	c.14092G>T	c.(14092-14094)GTG>TTG	p.V4698L	RYR1_uc002oiu.2_Missense_Mutation_p.V4693L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4698					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGACGATGACGTGAAGGGGCA	0.617													7	17	---	---	---	---	PASS
ZNF235	9310	broad.mit.edu	37	19	44791606	44791606	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:44791606C>A	uc002oza.3	-	5	2085	c.1982G>T	c.(1981-1983)GGG>GTG	p.G661V	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.G657V|ZNF235_uc010xwx.1_Missense_Mutation_p.G575V	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	661	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				GAATTCTTTCCCACATTCCTC	0.473													24	72	---	---	---	---	PASS
PPP1R13L	10848	broad.mit.edu	37	19	45895260	45895260	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:45895260C>G	uc002pbn.2	-	8	1770	c.1693G>C	c.(1693-1695)GAG>CAG	p.E565Q	PPP1R13L_uc002pbm.2_Missense_Mutation_p.E144Q|PPP1R13L_uc002pbo.2_Missense_Mutation_p.E565Q	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	565	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GGGGACAGCTCTGGCTCCGGC	0.697													21	41	---	---	---	---	PASS
SNRPD2	6633	broad.mit.edu	37	19	46190942	46190942	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:46190942C>T	uc002pcw.2	-	3	523	c.226G>A	c.(226-228)GAG>AAG	p.E76K	SNRPD2_uc002pcv.2_Missense_Mutation_p.E66K	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	76					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		TTGGGTACCTCAGTCCACATC	0.587													7	80	---	---	---	---	PASS
MEIS3	56917	broad.mit.edu	37	19	47912500	47912500	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:47912500G>A	uc002pgu.2	-	8	1161	c.714C>T	c.(712-714)GAC>GAT	p.D238D	MEIS3_uc010xyp.1_5'Flank|MEIS3_uc002pgo.2_Silent_p.D37D|MEIS3_uc002pgp.2_Silent_p.D70D|MEIS3_uc002pgq.2_Silent_p.D319D|MEIS3_uc002pgr.2_Silent_p.D106D|MEIS3_uc002pgt.2_Silent_p.D221D|MEIS3_uc002pgv.2_Silent_p.D221D|MEIS3_uc002pgs.2_Silent_p.D238D|MEIS3_uc010eld.2_Silent_p.D238D	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	238	Ser/Thr-rich.			D -> V (in Ref. 5).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TGTCCAGCCCGTCTCCTGAGG	0.607													5	8	---	---	---	---	PASS
GLTSCR2	29997	broad.mit.edu	37	19	48254807	48254807	+	Missense_Mutation	SNP	A	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:48254807A>C	uc002phm.2	+	5	653	c.629A>C	c.(628-630)GAT>GCT	p.D210A	GLTSCR2_uc002phk.2_Missense_Mutation_p.D210A|GLTSCR2_uc002phl.2_Missense_Mutation_p.D210A|GLTSCR2_uc010elj.2_Missense_Mutation_p.D210A|GLTSCR2_uc010elk.1_RNA	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	210				SDNPLDRPLVGQDEFFLE -> LNNPDKPVVWPGCLFPG (in Ref. 3; AAG30413).		nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		GTTGGCCAGGATGAGTTTTTC	0.607													7	16	---	---	---	---	PASS
MIR935	100126325	broad.mit.edu	37	19	54485587	54485587	+	RNA	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:54485587G>T	hsa-mir-935|MI0005757	+			c.27G>T			CACNG8_uc002qcs.1_Silent_p.G253G																	0						gcAGTGGCGGGAGCGGCCCCT	0.632													7	3	---	---	---	---	PASS
NLRP7	199713	broad.mit.edu	37	19	55451047	55451047	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr19:55451047C>T	uc002qih.3	-	4	1216	c.1140G>A	c.(1138-1140)GGG>GGA	p.G380G	NLRP7_uc002qig.3_Silent_p.G380G|NLRP7_uc002qii.3_Silent_p.G380G|NLRP7_uc010esk.2_Silent_p.G380G|NLRP7_uc010esl.2_Silent_p.G408G	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	380	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CCGGGTCCTCCCCCTTCTCCA	0.682													20	21	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20278858	20278858	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr20:20278858G>A	uc002wru.2	+	25	3326	c.3250G>A	c.(3250-3252)GGG>AGG	p.G1084R	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1084										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TGCGAAAAATGGGACTTACTT	0.433													8	70	---	---	---	---	PASS
GZF1	64412	broad.mit.edu	37	20	23346140	23346140	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr20:23346140G>A	uc010gdb.2	+	3	1294	c.1120G>A	c.(1120-1122)GAG>AAG	p.E374K	GZF1_uc002wsy.2_Missense_Mutation_p.E374K|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Missense_Mutation_p.E374K	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	374					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GCACAGCAGCGAGCGCCATTT	0.667													7	143	---	---	---	---	PASS
HCK	3055	broad.mit.edu	37	20	30661123	30661123	+	Missense_Mutation	SNP	G	A	A	rs149121640		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr20:30661123G>A	uc002wxh.2	+	3	356	c.185G>A	c.(184-186)GGG>GAG	p.G62E	HCK_uc010gdy.2_Missense_Mutation_p.G41E|HCK_uc002wxi.2_Missense_Mutation_p.G41E	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	62					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCCCCACAGGGGCCTAATAGC	0.398													47	14	---	---	---	---	PASS
DNMT3B	1789	broad.mit.edu	37	20	31393144	31393144	+	Missense_Mutation	SNP	G	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr20:31393144G>T	uc002wyc.2	+	21	2553	c.2232G>T	c.(2230-2232)AGG>AGT	p.R744S	DNMT3B_uc002wyd.2_Missense_Mutation_p.R724S|DNMT3B_uc002wye.2_Intron|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_Intron|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Missense_Mutation_p.R736S|DNMT3B_uc002wyg.2_Intron|DNMT3B_uc010geg.2_Missense_Mutation_p.R43S|DNMT3B_uc010geh.2_Intron	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	744					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						CTGTTCCCAGGCCCGTGATAG	0.498													24	34	---	---	---	---	PASS
SLCO4A1	28231	broad.mit.edu	37	20	61300296	61300296	+	Missense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr20:61300296C>A	uc002ydb.1	+	11	2096	c.1891C>A	c.(1891-1893)CCC>ACC	p.P631T	SLCO4A1_uc002ydc.1_RNA|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_Missense_Mutation_p.P33T	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	631	Helical; Name=11; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CATCCCGGGGCCCATCGCCTT	0.652											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25	---	---	---	---	PASS
KRTAP12-2	353323	broad.mit.edu	37	21	46086662	46086662	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr21:46086662C>T	uc002zfu.2	-	1	183	c.142G>A	c.(142-144)GTG>ATG	p.V48M	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181684	NP_859012	P59991	KR122_HUMAN	keratin associated protein 12-2	48	23 X 5 AA approximate repeats.|7.					keratin filament					0						TTGAAGCTCACGGGCACACAC	0.657													11	19	---	---	---	---	PASS
DDX17	10521	broad.mit.edu	37	22	38882080	38882080	+	Missense_Mutation	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr22:38882080G>C	uc003avy.3	-	13	2159	c.2056C>G	c.(2056-2058)CGG>GGG	p.R686G	DDX17_uc003avw.3_Missense_Mutation_p.R138G|DDX17_uc010gxp.2_Missense_Mutation_p.R136G|DDX17_uc003avx.3_Missense_Mutation_p.R684G	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	605					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					TGCCCAGACCGGCCTATCCCA	0.522													16	69	---	---	---	---	PASS
MAP3K15	389840	broad.mit.edu	37	X	19387265	19387265	+	Missense_Mutation	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:19387265C>T	uc004czk.1	-	26	3535	c.1898G>A	c.(1897-1899)GGC>GAC	p.G633D	MAP3K15_uc004czj.1_Missense_Mutation_p.G593D|MAP3K15_uc004czi.1_Missense_Mutation_p.G92D	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	1158							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					TGGGGGATAGCCCTCTTCCGC	0.592													24	14	---	---	---	---	PASS
MAGEB4	4115	broad.mit.edu	37	X	30260617	30260617	+	Missense_Mutation	SNP	A	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:30260617A>G	uc004dcb.2	+	1	449	c.365A>G	c.(364-366)TAC>TGC	p.Y122C	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	122	MAGE.									ovary(1)	1						TTCCTGCTGTACAAGTATAAA	0.438													4	2	---	---	---	---	PASS
FTHL17	53940	broad.mit.edu	37	X	31089535	31089535	+	Missense_Mutation	SNP	C	G	G			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:31089535C>G	uc004dcl.1	-	1	639	c.536G>C	c.(535-537)CGC>CCC	p.R179P		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	179					cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						CTCTTTGACGCGGCCGCCCAG	0.622													14	8	---	---	---	---	PASS
FAM47B	170062	broad.mit.edu	37	X	34961384	34961384	+	Silent	SNP	C	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:34961384C>T	uc004ddi.1	+	1	454	c.436C>T	c.(436-438)CTA>TTA	p.L146L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	146										ovary(3)|breast(1)	4						TCCAGATCTCCTACTACAGGT	0.572													12	10	---	---	---	---	PASS
RPGR	6103	broad.mit.edu	37	X	38145143	38145143	+	Nonsense_Mutation	SNP	C	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:38145143C>A	uc004ded.1	-	15	3277	c.3109G>T	c.(3109-3111)GAG>TAG	p.E1037*	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	826	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						tctccttcctcttcctctcct	0.030													3	8	---	---	---	---	PASS
TSIX	9383	broad.mit.edu	37	X	73045978	73045978	+	RNA	SNP	G	C	C			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:73045978G>C	uc004ebn.2	+	1		c.33939G>C			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						GCTGTTGCTGGCAGGTGCTTC	0.478													31	24	---	---	---	---	PASS
CSTF2	1478	broad.mit.edu	37	X	100077360	100077360	+	Silent	SNP	A	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:100077360A>T	uc004egh.2	+	3	316	c.258A>T	c.(256-258)GCA>GCT	p.A86A	CSTF2_uc010nnd.2_Silent_p.A86A|CSTF2_uc004egi.2_Silent_p.A86A	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	86	RRM.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						GTGGGAGAGCACTTCGAGTGG	0.458													16	7	---	---	---	---	PASS
CAPN6	827	broad.mit.edu	37	X	110491961	110491961	+	Silent	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:110491961G>A	uc004epc.1	-	10	1488	c.1320C>T	c.(1318-1320)TAC>TAT	p.Y440Y	CAPN6_uc011msu.1_Silent_p.Y185Y	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	440	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						GCTCCTGGATGTAGAGGTGGT	0.463													17	14	---	---	---	---	PASS
AGTR2	186	broad.mit.edu	37	X	115304285	115304285	+	Missense_Mutation	SNP	G	A	A			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:115304285G>A	uc004eqh.3	+	3	959	c.752G>A	c.(751-753)CGT>CAT	p.R251H		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	251	Cytoplasmic (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						AGGATAACCCGTGACCAAGTC	0.438													25	35	---	---	---	---	PASS
STARD4	134429	broad.mit.edu	37	5	110835780	110835780	+	Frame_Shift_Del	DEL	T	-	-			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr5:110835780delT	uc003kph.1	-	6	506	c.422delA	c.(421-423)AAGfs	p.K141fs	STARD4_uc010jbw.1_Frame_Shift_Del_p.K43fs|STARD4_uc010jbx.1_Frame_Shift_Del_p.K43fs|STARD4_uc003kpi.1_RNA	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	141	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TTCTGGTCTCTTTTCATCCCA	0.338													40	20	---	---	---	---	
TSC1	7248	broad.mit.edu	37	9	135785964	135785964	+	Frame_Shift_Del	DEL	G	-	-	rs118203506		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr9:135785964delG	uc004cca.2	-	12	1491	c.1257delC	c.(1255-1257)CCCfs	p.P419fs	TSC1_uc004ccb.3_Frame_Shift_Del_p.P418fs|TSC1_uc011mcq.1_Frame_Shift_Del_p.P368fs|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Frame_Shift_Del_p.P298fs|TSC1_uc004ccc.1_Frame_Shift_Del_p.P419fs	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	419					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GCACCTTCCTGGGGGGTGTGA	0.562			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				70	32	---	---	---	---	
UMOD	7369	broad.mit.edu	37	16	20348632	20348633	+	Frame_Shift_Ins	INS	-	T	T			TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chr16:20348632_20348633insT	uc002dgz.2	-	8	1849_1850	c.1720_1721insA	c.(1720-1722)ATGfs	p.M574fs	UMOD_uc002dha.2_Frame_Shift_Ins_p.M574fs|UMOD_uc002dhb.2_Frame_Shift_Ins_p.M607fs	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	574	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CTTTTCATTCATGGTGTCACAG	0.480													14	8	---	---	---	---	
FAM47A	158724	broad.mit.edu	37	X	34148741	34148779	+	In_Frame_Del	DEL	CGACGACTCTTGGGAAGCTCCGGGCGGAGACTGGACACT	-	-	rs45527437		TCGA-22-5478-01A-01D-1632-08	TCGA-22-5478-11A-11D-1632-08									Somatic	Phase_I	Capture				Illumina GAIIx	0ac704eb-d722-4c27-bfb4-fea6ca7af240	b903e396-c3d3-43e6-8742-3f99bb216ea2	g.chrX:34148741_34148779delCGACGACTCTTGGGAAGCTCCGGGCGGAGACTGGACACT	uc004ddg.2	-	1	1650_1688	c.1617_1655delAGTGTCCAGTCTCCGCCCGGAGCTTCCCAAGAGTCGTCG	c.(1615-1656)CGAGTGTCCAGTCTCCGCCCGGAGCTTCCCAAGAGTCGTCGG>CGG	p.539_552RVSSLRPELPKSRR>R		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	539_552										ovary(4)|central_nervous_system(1)	5						ACTGGACACCCGACGACTCTTGGGAAGCTCCGGGCGGAGACTGGACACTCGACGAGTCT	0.611													28	16	---	---	---	---	
