Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1572346	1572346	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:1572346C>T	uc001agv.1	-	20	1824	c.1713G>A	c.(1711-1713)GCG>GCA	p.A571A	CDK11B_uc009vkj.2_Silent_p.A228A|CDK11B_uc001ags.1_Silent_p.A429A|CDK11B_uc001agt.1_Silent_p.A354A|CDK11B_uc001aha.1_Silent_p.A537A|CDK11B_uc001agw.1_Silent_p.A526A|CDK11B_uc001agy.1_Silent_p.A569A|CDK11B_uc001agx.1_Silent_p.A560A|CDK11B_uc001agz.1_Silent_p.A315A	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	584	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CGTACTCCCGCGCCAGCCCGA	0.687000													15	21					0	0	0	0
CELA2B	51032	broad.mit.edu	37	1	15813844	15813844	+	Missense_Mutation	SNP	G	A	A	rs141194336	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:15813844G>A	uc001awl.2	+	7	729	c.704G>A	c.(703-705)GGC>GAC	p.G235D		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	235	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CATGGCATCGGCAGCCTCACG	0.577000													4	109					0	0	0	0
ZBTB17	7709	broad.mit.edu	37	1	16272657	16272657	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:16272657G>A	uc001axl.3	-	5	766	c.527C>T	c.(526-528)GCG>GTG	p.A176V	ZBTB17_uc010obq.1_Missense_Mutation_p.A93V|ZBTB17_uc010obr.1_Missense_Mutation_p.A176V|ZBTB17_uc010obs.1_Missense_Mutation_p.A100V|ZBTB17_uc010obt.1_Missense_Mutation_p.A113V|ZBTB17_uc010obu.1_Missense_Mutation_p.A100V|ZBTB17_uc009vom.1_Missense_Mutation_p.A119V|ZBTB17_uc010obv.1_Missense_Mutation_p.A176V	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	176					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		ACCGCTGGCCGCACTCTGGGC	0.687000													4	145					0	0	0	0
BAI2	576	broad.mit.edu	37	1	32221927	32221927	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:32221927G>T	uc001btn.2	-	4	865	c.511C>A	c.(511-513)CGC>AGC	p.R171S	BAI2_uc010ogp.1_Missense_Mutation_p.R159S|BAI2_uc010ogq.1_Missense_Mutation_p.R171S|BAI2_uc001bto.2_Missense_Mutation_p.R171S|BAI2_uc001btq.1_Missense_Mutation_p.R159S|BAI2_uc010ogr.1_Missense_Mutation_p.R159S	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	171	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GCCAGCAGGCGCGGGGCCTCG	0.622000													9	76					0.000442599	0.000464305	1	0
TEKT2	27285	broad.mit.edu	37	1	36552864	36552864	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:36552864G>T	uc001bzr.2	+	7	934	c.807G>T	c.(805-807)CTG>CTT	p.L269L	TEKT2_uc001bzs.2_Silent_p.L175L|ADPRHL2_uc001bzt.2_5'Flank|ADPRHL2_uc001bzu.2_5'Flank	NM_014466	NP_055281	Q9UIF3	TEKT2_HUMAN	tektin 2	269	Potential.				cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAAGCGGCTGCGGGAGATGG	0.542000													13	50					2.61681e-11	2.98718e-11	1	0
SLC6A9	6536	broad.mit.edu	37	1	44467985	44467985	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:44467985C>T	uc001cll.2	-	8	1373	c.1181G>A	c.(1180-1182)CGG>CAG	p.R394Q	SLC6A9_uc009vxe.2_Missense_Mutation_p.R250Q|SLC6A9_uc010okm.1_Missense_Mutation_p.R321Q|SLC6A9_uc001clm.2_Missense_Mutation_p.R340Q|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.R325Q|SLC6A9_uc001cln.2_Missense_Mutation_p.R321Q|SLC6A9_uc010oko.1_Missense_Mutation_p.R210Q|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	394						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GAGCACTCACCGGTAACAGTT	0.607000													12	74					0	0	0	0
DAB1	1600	broad.mit.edu	37	1	57537304	57537304	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:57537304A>G	uc001cys.1	-	8	1123	c.449T>C	c.(448-450)GTT>GCT	p.V150A	DAB1_uc001cyt.1_Missense_Mutation_p.V150A|DAB1_uc001cyq.1_Missense_Mutation_p.V150A|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Missense_Mutation_p.V150A|DAB1_uc009vzx.1_Missense_Mutation_p.V150A	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	150	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						GTCCAGAATAACAGGTTCAGC	0.418000													21	48					0	0	0	0
LRRC7	57554	broad.mit.edu	37	1	70555441	70555441	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:70555441T>C	uc001dep.2	+	23	4400	c.4370T>C	c.(4369-4371)CTT>CCT	p.L1457P	LRRC7_uc009wbg.2_Missense_Mutation_p.L741P|LRRC7_uc001deq.2_Missense_Mutation_p.L651P	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1457	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AATCCTGGCCTTGGATTTAGT	0.289000													22	114					0	0	0	0
ZRANB2	9406	broad.mit.edu	37	1	71542527	71542527	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:71542527C>A	uc001dft.2	-	4	319	c.252G>T	c.(250-252)GAG>GAT	p.E84D	ZRANB2_uc001dfs.2_Missense_Mutation_p.E84D	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	84	RanBP2-type 2.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACATATTACACTCTGATCTTC	0.264000													10	99					6.40141e-05	6.7877e-05	1	0
C1orf173	127254	broad.mit.edu	37	1	75055489	75055489	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:75055489C>A	uc001dgg.2	-	12	2221	c.2002G>T	c.(2002-2004)GTT>TTT	p.V668F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.V462F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	668	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTTTAAGAACATTCTCAAAG	0.398000													22	149					3.01185e-09	3.33745e-09	1	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77094330	77094330	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:77094330T>C	uc001dhh.2	+	5	920	c.757T>C	c.(757-759)TAC>CAC	p.Y253H	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.Y152H	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	253	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						AAAAGTCCCCTACCATTATTA	0.313000													17	77					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86426969	86426969	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:86426969A>G	uc001dlj.2	-	24	2567	c.2525T>C	c.(2524-2526)GTA>GCA	p.V842A	COL24A1_uc001dli.2_5'UTR|COL24A1_uc010osd.1_Missense_Mutation_p.V142A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	842	Collagen-like 5.			GYAGEPGPEGLKGEVGDQGNIG -> ITVFATLYSFLTGRS RRSRKYW (in Ref. 5; BAD92923).	cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTGATCTCCTACTTCTCCCTG	0.269000													26	84					0	0	0	0
BARHL2	343472	broad.mit.edu	37	1	91182748	91182748	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:91182748G>T	uc001dns.2	-	1	47	c.5C>A	c.(4-6)ACA>AAA	p.T2K		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	2						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CCCTTCCATTGTCATTGCTAC	0.527000													17	136					1.45105e-14	1.69577e-14	1	0
HFM1	164045	broad.mit.edu	37	1	91781966	91781966	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:91781966A>T	uc001doa.3	-	26	2980	c.2880T>A	c.(2878-2880)GAT>GAA	p.D960E	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.D639E|HFM1_uc001dob.3_Missense_Mutation_p.D148E|HFM1_uc010osv.1_Missense_Mutation_p.D644E	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	960	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTTCCCTTGCATCTGTCTCTT	0.299000													48	122					0	0	0	0
SLC44A3	126969	broad.mit.edu	37	1	95322999	95322999	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:95322999T>A	uc001dqv.3	+	10	1288	c.1181T>A	c.(1180-1182)ATC>AAC	p.I394N	SLC44A3_uc001dqx.3_Missense_Mutation_p.I394N|SLC44A3_uc010otq.1_Missense_Mutation_p.I326N|SLC44A3_uc010otr.1_Missense_Mutation_p.I358N|SLC44A3_uc001dqw.3_Missense_Mutation_p.I346N|SLC44A3_uc010ots.1_Missense_Mutation_p.I314N|SLC44A3_uc009wds.2_Missense_Mutation_p.I297N|SLC44A3_uc010ott.1_Missense_Mutation_p.I314N|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	394	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	AGTGAATTCATCCTTGCGTGC	0.448000													64	166					0	0	0	0
SLC44A3	126969	broad.mit.edu	37	1	95332973	95332973	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:95332973G>C	uc001dqv.3	+	12	1589	c.1482G>C	c.(1480-1482)CAG>CAC	p.Q494H	SLC44A3_uc001dqx.3_Missense_Mutation_p.Q493H|SLC44A3_uc010otq.1_Missense_Mutation_p.Q426H|SLC44A3_uc010otr.1_Missense_Mutation_p.Q458H|SLC44A3_uc001dqw.3_Missense_Mutation_p.Q446H|SLC44A3_uc010ots.1_Missense_Mutation_p.Q414H|SLC44A3_uc009wds.2_Missense_Mutation_p.Q397H|SLC44A3_uc010ott.1_Missense_Mutation_p.Q413H|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	494						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	ATCTCAACCAGGTACGTCTCT	0.423000													25	165					0	0	0	0
AMY2B	280	broad.mit.edu	37	1	104114736	104114736	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:104114736C>G	uc001duq.2	+	4	789	c.173C>G	c.(172-174)TCT>TGT	p.S58C	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.S58C	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	58					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTGTAGGTCTCTCCACCAAAT	0.313000													50	282					0	0	0	0
AMY2B	280	broad.mit.edu	37	1	104115822	104115822	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:104115822T>C	uc001duq.2	+	5	1069	c.453T>C	c.(451-453)TTT>TTC	p.F151F	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.F151F|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	151					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GATGGGATTTTAATGATGGTA	0.408000													71	797					0	0	0	0
PRMT6	55170	broad.mit.edu	37	1	107600360	107600360	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:107600360C>G	uc010ous.1	+	1	1094	c.1023C>G	c.(1021-1023)ATC>ATG	p.I341M		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	341					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		CAGGAGAGATCACGCTGCTGC	0.617000													9	45					0	0	0	0
LOC645166	645166	broad.mit.edu	37	1	148932792	148932792	+	RNA	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:148932792G>T	uc010pbc.1	+	2		c.107G>T			LOC645166_uc010pbd.1_RNA|LOC645166_uc009wkw.1_RNA	NR_027355				Homo sapiens cDNA, FLJ18771.												0						GCAGACTGCTGGCCAGACCCC	0.582000													11	285					4.96729e-08	5.45515e-08	1	0
NES	10763	broad.mit.edu	37	1	156641773	156641773	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:156641773A>G	uc001fpq.2	-	4	2340	c.2207T>C	c.(2206-2208)CTA>CCA	p.L736P		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	736	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCTGTTTCTAGAGGTCTCAC	0.428000													66	202					0	0	0	0
CD1A	909	broad.mit.edu	37	1	158224885	158224885	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158224885C>A	uc001frt.2	+	2	603	c.70C>A	c.(70-72)CCT>ACT	p.P24T		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	24	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GCTCAAGGAGCCTCTCTCCTT	0.483000													4	188					0.000602214	0.000629065	1	0
OR10K2	391107	broad.mit.edu	37	1	158389862	158389862	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158389862G>C	uc010pii.1	-	1	795	c.795C>G	c.(793-795)AAC>AAG	p.N265K		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TTGAGGAGTAGTTGGACTGAG	0.398000													41	96					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158585170	158585170	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158585170C>T	uc001fst.1	-	48	6823	c.6624G>A	c.(6622-6624)GCG>GCA	p.A2208A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2208	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GACGCTTCATCGCCTGGATCT	0.468000													92	198					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158669837	158669837	+	Silent	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158669837G>C	uc001fsu.1	-	1	606	c.606C>G	c.(604-606)GTC>GTG	p.V202V		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CTGCATGAATGACATCCACTA	0.483000													33	115					0	0	0	0
IGSF9	57549	broad.mit.edu	37	1	159897613	159897613	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:159897613G>A	uc001fur.2	-	20	3493	c.3295C>T	c.(3295-3297)CTG>TTG	p.L1099L	IGSF9_uc001fuq.2_Silent_p.L1083L|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.L245L	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1099	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AAAGTCTCCAGCAATTCCATG	0.527000													32	103					0	0	0	0
RXRG	6258	broad.mit.edu	37	1	165380003	165380004	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:165380003_165380004CC>AT	uc001gda.2	-	6	1148_1149	c.848_849GG>AT	c.(847-849)TGG>TAT	p.W283Y		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	283	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TACGCTTGGCCCATTCAACGAG	0.490000													7	47					0	0	0	0
QSOX1	5768	broad.mit.edu	37	1	180165686	180165686	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:180165686G>T	uc001gnz.2	+	12	1833	c.1758G>T	c.(1756-1758)ATG>ATT	p.M586I	QSOX1_uc001gny.2_Missense_Mutation_p.M586I|QSOX1_uc001goa.2_Missense_Mutation_p.M586I|QSOX1_uc001goc.2_Missense_Mutation_p.M128I|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	586					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						CTGAGATGATGAAGTCCCCCA	0.637000													45	132					2.20914e-33	2.85275e-33	1	0
LAMC1	3915	broad.mit.edu	37	1	183105651	183105651	+	Silent	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:183105651T>G	uc001gpy.3	+	25	4502	c.4245T>G	c.(4243-4245)GCT>GCG	p.A1415A		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1415	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGCAGTGCTGCGGCGGATG	0.592000													4	53					0	0	0	0
ZBTB41	360023	broad.mit.edu	37	1	197128771	197128771	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197128771C>T	uc001gtx.1	-	10	2517	c.2448G>A	c.(2446-2448)CAG>CAA	p.Q816Q	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	816					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TGTCAGGCATCTGAACTGGAA	0.463000													52	120					0	0	0	0
CRB1	23418	broad.mit.edu	37	1	197390919	197390919	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197390919C>T	uc001gtz.2	+	6	2096	c.1961C>T	c.(1960-1962)ACC>ATC	p.T654I	CRB1_uc010poz.1_Missense_Mutation_p.T585I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.T542I|CRB1_uc010ppb.1_Missense_Mutation_p.T654I|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.T135I|CRB1_uc001gub.1_Missense_Mutation_p.T303I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	654	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.T654T(1)		ovary(5)|skin(3)|large_intestine(1)	9						AATCACATTACCCTGGAGAAC	0.448000													68	218					0	0	0	0
CRB1	23418	broad.mit.edu	37	1	197404293	197404293	+	Missense_Mutation	SNP	A	G	G	rs146270698	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197404293A>G	uc001gtz.2	+	9	3435	c.3300A>G	c.(3298-3300)ATA>ATG	p.I1100M	CRB1_uc010poz.1_Missense_Mutation_p.I1076M|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.I988M|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.I581M|CRB1_uc001gub.1_Missense_Mutation_p.I749M	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1100	Extracellular (Potential).|Laminin G-like 3.		I -> R (in LCA8).|I -> T (in RP12).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TAAGTACAATAGAAATCGGAG	0.368000													47	119					0	0	0	0
IPO9	55705	broad.mit.edu	37	1	201839980	201839980	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:201839980C>T	uc001gwz.2	+	18	2453	c.2403C>T	c.(2401-2403)GTC>GTT	p.V801V		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	801					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CGCTCAGTGTCATGCAGGTAA	0.498000													12	70					0	0	0	0
IKBKE	9641	broad.mit.edu	37	1	206648211	206648211	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:206648211G>A	uc001hdz.1	+	5	600	c.232G>A	c.(232-234)GGA>AGA	p.G78R	IKBKE_uc009xbu.1_Missense_Mutation_p.G78R|IKBKE_uc009xbv.1_Missense_Mutation_p.G78R|IKBKE_uc001hea.1_5'UTR	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	78	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCCATAGGGCGGAAGCCGGCA	0.617000													7	50					0	0	0	0
DYRK3	8444	broad.mit.edu	37	1	206821624	206821624	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:206821624T>G	uc001hej.2	+	3	1249	c.1081T>G	c.(1081-1083)TTC>GTC	p.F361V	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Missense_Mutation_p.F341V	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	361	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GTCCAGCTGTTTCGAGTACCA	0.453000													12	188					0	0	0	0
FCAMR	83953	broad.mit.edu	37	1	207135666	207135666	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:207135666C>A	uc001hfa.3	-	5	1044	c.544G>T	c.(544-546)GTG>TTG	p.V182L	FCAMR_uc001hfb.2_Missense_Mutation_p.V182L|FCAMR_uc009xca.1_Missense_Mutation_p.V182L|FCAMR_uc001hfc.2_Missense_Mutation_p.V157L	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	137	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGCCTCACCACAAACAAGCCT	0.507000													3	50					2.32078e-09	2.59506e-09	1	0
INTS7	25896	broad.mit.edu	37	1	212118271	212118271	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:212118271A>G	uc001hiw.1	-	19	2561	c.2456T>C	c.(2455-2457)ATT>ACT	p.I819T	INTS7_uc009xdb.1_Missense_Mutation_p.I799T|INTS7_uc001hix.1_Missense_Mutation_p.I695T|INTS7_uc001hiy.1_Missense_Mutation_p.I805T|INTS7_uc010pta.1_Missense_Mutation_p.I770T	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	819					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGGACAGCAATGGGCTCTGC	0.512000													23	72					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216074210	216074210	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:216074210G>A	uc001hku.1	-	39	7725	c.7338C>T	c.(7336-7338)GCC>GCT	p.A2446A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2446	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTTGGAGTGGCAGATGAAA	0.517000										HNSCC(13;0.011)			26	91					0	0	0	0
KIAA1383	54627	broad.mit.edu	37	1	232941433	232941433	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:232941433G>C	uc001hvh.2	+	1	796	c.664G>C	c.(664-666)GCC>CCC	p.A222P		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	80										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CGCTCCCGCCGCCGAACCGTG	0.721000													4	20					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237666648	237666648	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:237666648A>G	uc001hyl.1	+	22	2576	c.2456A>G	c.(2455-2457)TAT>TGT	p.Y819C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	819	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCACCTGGGTATGCTCCTTGT	0.458000													8	34					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237935319	237935319	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:237935319G>A	uc001hyl.1	+	86	11685	c.11565G>A	c.(11563-11565)CAG>CAA	p.Q3855Q	RYR2_uc010pya.1_Silent_p.Q270Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3855					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAGATTTTCAGAATTATCTGA	0.343000													5	7					0	0	0	0
ECHDC3	79746	broad.mit.edu	37	10	11805415	11805415	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:11805415G>A	uc001ikw.3	+	5	1004	c.784G>A	c.(784-786)GAC>AAC	p.D262N	ECHDC3_uc009xix.2_Missense_Mutation_p.D131N	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	262						mitochondrion	catalytic activity				0						GCTGCCCCAGGACCTGGGGAC	0.637000													25	55					0	0	0	0
SEPHS1	22929	broad.mit.edu	37	10	13361236	13361236	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:13361236C>T	uc001imk.2	-	9	1444	c.1085G>A	c.(1084-1086)CGC>CAC	p.R362H	SEPHS1_uc001imh.2_Missense_Mutation_p.R286H|SEPHS1_uc010qbs.1_Missense_Mutation_p.R314H|SEPHS1_uc001imi.2_Missense_Mutation_p.R360H|SEPHS1_uc001imj.2_3'UTR|SEPHS1_uc010qbt.1_Missense_Mutation_p.R295H	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	362					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						TCTGGCTGTGCGGTTGCCCTT	0.522000													12	735					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16873368	16873368	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:16873368C>T	uc001ioo.2	-	65	10463	c.10411G>A	c.(10411-10413)GGA>AGA	p.G3471R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3471	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCAGAGTTCCACAGTACTTG	0.373000													48	202					0	0	0	0
NEBL	10529	broad.mit.edu	37	10	21139422	21139422	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:21139422T>C	uc001iqi.2	-	11	1415	c.1018A>G	c.(1018-1020)AAA>GAA	p.K340E	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	340	Nebulin 9.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TATTCTTCTTTATATTTCACC	0.318000													45	132					0	0	0	0
ZEB1	6935	broad.mit.edu	37	10	31810534	31810534	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:31810534G>C	uc001ivs.3	+	7	2334	c.2271G>C	c.(2269-2271)CAG>CAC	p.Q757H	ZEB1_uc001ivr.3_Missense_Mutation_p.Q539H|ZEB1_uc010qee.1_Missense_Mutation_p.Q539H|ZEB1_uc010qef.1_Missense_Mutation_p.Q539H|ZEB1_uc009xlj.1_Missense_Mutation_p.Q683H|ZEB1_uc010qeg.1_Missense_Mutation_p.Q616H|ZEB1_uc009xlk.1_Missense_Mutation_p.Q539H|ZEB1_uc001ivt.3_Missense_Mutation_p.Q539H|ZEB1_uc001ivu.3_Missense_Mutation_p.Q758H|ZEB1_uc001ivv.3_Missense_Mutation_p.Q737H|ZEB1_uc010qeh.1_Missense_Mutation_p.Q690H|ZEB1_uc009xlo.1_Missense_Mutation_p.Q740H|ZEB1_uc009xlp.2_Missense_Mutation_p.Q741H	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	757					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GTGTTTACCAGAACAGTGTTT	0.418000													58	92					0	0	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32128565	32128565	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:32128565T>C	uc001ivz.1	-	8	1641	c.1371A>G	c.(1369-1371)ACA>ACG	p.T457T	ARHGAP12_uc001ivy.1_Silent_p.T408T|ARHGAP12_uc009xls.2_Silent_p.T408T|ARHGAP12_uc001iwb.1_Silent_p.T455T|ARHGAP12_uc001iwc.1_Intron|ARHGAP12_uc009xlq.1_Intron|ARHGAP12_uc001iwd.1_Intron|ARHGAP12_uc009xlr.1_Silent_p.T455T	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	457					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TCATACTAACTGTATCTTGGT	0.328000													32	73					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505229	37505229	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:37505229G>A	uc001iza.1	+	32	2921	c.2822G>A	c.(2821-2823)TGT>TAT	p.C941Y		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AAGAAGTTTTGTGTACTGAAA	0.353000													25	103					0	0	0	0
A1CF	29974	broad.mit.edu	37	10	52570857	52570857	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:52570857C>G	uc001jjj.2	-	11	1615	c.1427G>C	c.(1426-1428)AGA>ACA	p.R476T	A1CF_uc010qhn.1_Missense_Mutation_p.R476T|A1CF_uc001jji.2_Missense_Mutation_p.R468T|A1CF_uc001jjh.2_Missense_Mutation_p.R476T|A1CF_uc010qho.1_Missense_Mutation_p.R484T|A1CF_uc009xov.2_Missense_Mutation_p.R468T	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	476					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GAATAGCTGTCTTTGGTCTTG	0.388000													15	67					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	56106239	56106239	+	Silent	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:56106239A>T	uc001jju.1	-	6	875	c.480T>A	c.(478-480)ACT>ACA	p.T160T	PCDH15_uc010qhq.1_Silent_p.T165T|PCDH15_uc010qhr.1_Silent_p.T160T|PCDH15_uc010qhs.1_Silent_p.T165T|PCDH15_uc010qht.1_Silent_p.T160T|PCDH15_uc010qhu.1_Silent_p.T160T|PCDH15_uc001jjv.1_Silent_p.T138T|PCDH15_uc010qhv.1_Silent_p.T160T|PCDH15_uc010qhw.1_Silent_p.T160T|PCDH15_uc010qhx.1_Silent_p.T160T|PCDH15_uc010qhy.1_Silent_p.T165T|PCDH15_uc010qhz.1_Silent_p.T160T|PCDH15_uc010qia.1_Silent_p.T138T|PCDH15_uc010qib.1_Silent_p.T138T|PCDH15_uc001jjw.2_Silent_p.T160T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	160	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACCAACTGGAGTGAGCTGAA	0.333000										HNSCC(58;0.16)			34	185					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	56138617	56138617	+	Silent	SNP	C	A	A	rs151119732	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:56138617C>A	uc001jju.1	-	4	638	c.243G>T	c.(241-243)GTG>GTT	p.V81V	PCDH15_uc010qhq.1_Silent_p.V86V|PCDH15_uc010qhr.1_Silent_p.V81V|PCDH15_uc010qhs.1_Silent_p.V86V|PCDH15_uc010qht.1_Silent_p.V81V|PCDH15_uc010qhu.1_Silent_p.V81V|PCDH15_uc001jjv.1_Silent_p.V59V|PCDH15_uc010qhv.1_Silent_p.V81V|PCDH15_uc010qhw.1_Silent_p.V81V|PCDH15_uc010qhx.1_Silent_p.V81V|PCDH15_uc010qhy.1_Silent_p.V86V|PCDH15_uc010qhz.1_Silent_p.V81V|PCDH15_uc010qia.1_Silent_p.V59V|PCDH15_uc010qib.1_Silent_p.V59V|PCDH15_uc001jjw.2_Silent_p.V81V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	81	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CCCAGTAATCCACATTATCCT	0.433000										HNSCC(58;0.16)			80	221					4.03997e-35	5.25838e-35	1	0
C10orf58	84293	broad.mit.edu	37	10	82187166	82187166	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:82187166C>T	uc001kcc.3	+	5	650	c.490C>T	c.(490-492)CGA>TGA	p.R164*	C10orf58_uc001kcd.3_Nonsense_Mutation_p.R153*|C10orf58_uc001kce.3_Nonsense_Mutation_p.R164*|C10orf58_uc001kcf.3_Nonsense_Mutation_p.R164*	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	164						extracellular region					0			Colorectal(32;0.229)			CAACTTCTTCCGAGCCTGGAA	0.488000													22	167					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	107022247	107022247	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:107022247T>C	uc001kyi.1	+	26	3829	c.3602T>C	c.(3601-3603)ATA>ACA	p.I1201T		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1201	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACGCGGGTCATAGGTACATGC	0.542000													25	63					0	0	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114205170	114205170	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:114205170T>C	uc001kzv.2	-	2	449	c.25A>G	c.(25-27)AAG>GAG	p.K9E	VTI1A_uc001kzy.2_5'Flank|VTI1A_uc001kzz.2_5'Flank|ZDHHC6_uc001kzw.2_Missense_Mutation_p.K9E|ZDHHC6_uc009xya.1_Missense_Mutation_p.K9E|VTI1A_uc001kzx.2_5'Flank	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	9						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		TTTTCAAACTTGATAACCGAA	0.398000													3	88					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	117884808	117884808	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:117884808C>G	uc001lcj.2	-	6	1392	c.694G>C	c.(694-696)GTG>CTG	p.V232L	GFRA1_uc001lci.2_Missense_Mutation_p.V227L|GFRA1_uc009xyr.2_Missense_Mutation_p.V227L	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	232	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TAGGAGCACACAGGCACGATG	0.562000													32	73					0	0	0	0
TH	7054	broad.mit.edu	37	11	2189385	2189385	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:2189385G>T	uc001lvq.2	-	5	624	c.605C>A	c.(604-606)TCA>TAA	p.S202*	TH_uc001lvp.2_Nonsense_Mutation_p.S198*|TH_uc001lvr.2_Nonsense_Mutation_p.S171*|TH_uc010qxj.1_Nonsense_Mutation_p.S175*|TH_uc001lvs.2_Nonsense_Mutation_p.S171*|TH_uc001lvt.2_Nonsense_Mutation_p.S175*|TH_uc009ydh.1_RNA	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	202					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GTCCAGCTCTGACACTTTTCT	0.597000													25	57					2.79863e-10	3.15086e-10	1	0
OR52I2	143502	broad.mit.edu	37	11	4608360	4608360	+	Silent	SNP	G	C	C	rs149411057	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:4608360G>C	uc010qyh.1	+	1	318	c.318G>C	c.(316-318)TCG>TCC	p.S106S		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCCTCCTCGGTGGTACCCA	0.493000													68	204					0	0	0	0
OR52D1	390066	broad.mit.edu	37	11	5510546	5510546	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:5510546A>G	uc010qzg.1	+	1	610	c.610A>G	c.(610-612)ACT>GCT	p.T204A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTATGGGCTAACTGTGGCTCT	0.493000													98	193					0	0	0	0
OR10A5	144124	broad.mit.edu	37	11	6867339	6867339	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6867339G>T	uc001met.1	+	1	426	c.426G>T	c.(424-426)CGG>CGT	p.R142R		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAGGACACGGGCCAAACTGG	0.537000													16	194					2.35188e-11	2.69099e-11	1	0
OR10A5	144124	broad.mit.edu	37	11	6867357	6867357	+	Silent	SNP	T	C	C	rs145237850		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6867357T>C	uc001met.1	+	1	444	c.444T>C	c.(442-444)GCT>GCC	p.A148A		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGGCTGCTGCTTCCTGGTTCC	0.527000													12	157					0	0	0	0
OR10A2	341276	broad.mit.edu	37	11	6891366	6891366	+	Silent	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6891366T>A	uc001meu.1	+	1	381	c.381T>A	c.(379-381)ACT>ACA	p.T127T		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	127	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACCAAAGGACTCGTGCCAAAC	0.537000													7	235					0	0	0	0
NELL1	4745	broad.mit.edu	37	11	20939793	20939793	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:20939793A>G	uc001mqe.2	+	6	822	c.669A>G	c.(667-669)CTA>CTG	p.L223L	NELL1_uc001mqf.2_Silent_p.L223L|NELL1_uc009yid.2_Silent_p.L251L|NELL1_uc010rdo.1_Silent_p.L166L|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	223	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTCCAAATCTAAATCACAGTA	0.343000													65	101					0	0	0	0
NELL1	4745	broad.mit.edu	37	11	21581766	21581766	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:21581766C>T	uc001mqe.2	+	17	1971	c.1818C>T	c.(1816-1818)ACC>ACT	p.T606T	NELL1_uc001mqf.2_Silent_p.T559T|NELL1_uc009yid.2_Silent_p.T634T|NELL1_uc010rdo.1_Silent_p.T549T|NELL1_uc010rdp.1_Silent_p.T319T|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	606	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GAACTCACACCTGTTGGAACG	0.502000													66	130					0	0	0	0
SLC17A6	57084	broad.mit.edu	37	11	22360160	22360160	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:22360160C>G	uc001mqk.2	+	1	494	c.81C>G	c.(79-81)ATC>ATG	p.I27M		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	27	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TCGGCCAGATCTACAGGTAAG	0.453000													15	32					0	0	0	0
HIPK3	10114	broad.mit.edu	37	11	33375104	33375104	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:33375104C>A	uc001mul.1	+	17	3908	c.3638C>A	c.(3637-3639)CCA>CAA	p.P1213Q	HIPK3_uc001mum.1_Missense_Mutation_p.P1192Q|HIPK3_uc009yjv.1_Missense_Mutation_p.P1192Q	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	1213					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						AGCCAGTATCCATATATGTGA	0.353000													51	57					2.27781e-18	2.78085e-18	1	0
ALX4	60529	broad.mit.edu	37	11	44297071	44297071	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:44297071A>G	uc001myb.2	-	2	708	c.604T>C	c.(604-606)TTG>CTG	p.L202L		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	202					hair follicle development						0						GCCTTCTCCAATGGGCTGGGG	0.617000													93	178					0	0	0	0
LRP4	4038	broad.mit.edu	37	11	46896618	46896618	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:46896618G>A	uc001ndn.3	-	28	4108	c.3962C>T	c.(3961-3963)TCC>TTC	p.S1321F		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1321	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GCAGAGGTGGGAGCAGCCGCC	0.547000													13	28					0	0	0	0
OR4C16	219428	broad.mit.edu	37	11	55339627	55339628	+	Nonsense_Mutation	DNP	TG	CT	CT			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:55339627_55339628TG>CT	uc010rih.1	+	1	24_25	c.24_25TG>CT	c.(22-27)ACTGAG>ACCTAG	p.E9*		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATAATGTGACTGAGTTCATTCT	0.376000													5	115					0	0	0	0
OR5M3	219482	broad.mit.edu	37	11	56237559	56237559	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:56237559A>G	uc010rjk.1	-	1	415	c.415T>C	c.(415-417)TGT>CGT	p.C139R		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	139	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AGTCGAATACAGACAACCCTT	0.398000													67	130					0	0	0	0
OR5A2	219981	broad.mit.edu	37	11	59190426	59190426	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:59190426T>C	uc010rkt.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTACAGCCATAGGCCTGCTT	0.378000													77	182					0	0	0	0
PITPNM1	9600	broad.mit.edu	37	11	67261436	67261436	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:67261436G>A	uc001olx.2	-	19	3154	c.2965C>T	c.(2965-2967)CGC>TGC	p.R989C	PITPNM1_uc001olw.2_Missense_Mutation_p.R271C|PITPNM1_uc001oly.2_Missense_Mutation_p.R989C|PITPNM1_uc001olz.2_Missense_Mutation_p.R988C	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	989					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CCCAGCGCGCGTTCTGGGGGA	0.572000													9	20					0	0	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276971	71276971	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:71276971G>A	uc001oqt.1	+	1	363	c.338G>A	c.(337-339)GGC>GAC	p.G113D		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	113	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						TCCAAGGGGGGCTGTGGCTCC	0.657000													5	168					0	0	0	0
NARS2	79731	broad.mit.edu	37	11	78279726	78279726	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:78279726C>A	uc001ozi.2	-	3	700	c.324G>T	c.(322-324)GTG>GTT	p.V108V	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	108					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CCTTCAGTTCCACATTTTGCC	0.348000													53	117					1.63038e-21	2.03075e-21	1	0
DLG2	1740	broad.mit.edu	37	11	83673957	83673957	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:83673957C>A	uc001paj.2	-	9	1299	c.996G>T	c.(994-996)AAG>AAT	p.K332N	DLG2_uc001pai.2_Missense_Mutation_p.K281N|DLG2_uc010rsy.1_Missense_Mutation_p.K299N|DLG2_uc010rsz.1_Missense_Mutation_p.K332N|DLG2_uc010rta.1_Missense_Mutation_p.K332N|DLG2_uc001pak.2_Missense_Mutation_p.K437N|DLG2_uc010rtb.1_Missense_Mutation_p.K299N|DLG2_uc001pal.1_Missense_Mutation_p.K332N|DLG2_uc001pam.1_Missense_Mutation_p.K371N	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	332						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CAAGCATGTGCTTTGGAATTG	0.428000													73	189					1.1397e-45	1.50735e-45	1	0
GRM5	2915	broad.mit.edu	37	11	88386571	88386571	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:88386571A>T	uc001pcq.2	-	3	1112	c.912T>A	c.(910-912)AGT>AGA	p.S304R	GRM5_uc009yvm.2_Missense_Mutation_p.S304R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	304	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCCAGCCATCACTGTGGGGAA	0.433000													28	30					0	0	0	0
Unknown	0	broad.mit.edu	37	11	89486284	89486284	+	IGR	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:89486284A>G								TRIM77 (35246 upstream) : TRIM49 (44540 downstream)																							CCAGAGATCCAATTTCACCTT	0.488000													8	120					0	0	0	0
UBTFL1	642623	broad.mit.edu	37	11	89819194	89819194	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:89819194G>C	uc010rub.1	+	1	77	c.77G>C	c.(76-78)CGC>CCC	p.R26P		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	26					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						GAGAATAATCGCCCATCTGAT	0.418000													30	80					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92085313	92085313	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:92085313G>T	uc001pdj.3	+	1	52	c.35G>T	c.(34-36)CGG>CTG	p.R12L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	12					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGGCACACGGCCTCCTGCT	0.502000										TCGA Ovarian(4;0.039)			11	85					9.31168e-06	9.98115e-06	1	0
FAT3	120114	broad.mit.edu	37	11	92086560	92086560	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:92086560C>A	uc001pdj.3	+	1	1299	c.1282C>A	c.(1282-1284)CTG>ATG	p.L428M		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	428	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCGGTCGGGTCTGATTGTTAC	0.408000										TCGA Ovarian(4;0.039)			9	20					1.58986e-06	1.72294e-06	1	0
CEP57	9702	broad.mit.edu	37	11	95564303	95564303	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:95564303G>A	uc001pfp.1	+	11	1607	c.1386G>A	c.(1384-1386)AAG>AAA	p.K462K	CEP57_uc010ruh.1_Silent_p.K453K|CEP57_uc010rui.1_Silent_p.K436K|CEP57_uc009ywn.1_Silent_p.K310K|CEP57_uc001pfq.1_Silent_p.K436K|CEP57_uc001pfr.1_Silent_p.K310K	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	462	Mediates interaction with microtubules (By similarity).|Potential.				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCACAAATAAGAAAGATTTTA	0.363000									Mosaic_Variegated_Aneuploidy_Syndrome				9	60					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	100211321	100211321	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:100211321T>C	uc001pga.2	+	22	3196	c.2857T>C	c.(2857-2859)TAC>CAC	p.Y953H	CNTN5_uc001pgb.2_Missense_Mutation_p.Y879H|CNTN5_uc010ruk.1_Missense_Mutation_p.Y224H	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	953	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGTGAGGGCTTACAATGGAGC	0.448000													9	26					0	0	0	0
KIAA1377	57562	broad.mit.edu	37	11	101863550	101863550	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:101863550A>G	uc001pgm.2	+	10	3556	c.3286A>G	c.(3286-3288)ACT>GCT	p.T1096A	KIAA1377_uc001pgn.2_Missense_Mutation_p.T1052A|KIAA1377_uc010run.1_Missense_Mutation_p.T897A	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1096							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CATCAAAAATACTTTACAAAT	0.259000													6	27					0	0	0	0
MMP1	4312	broad.mit.edu	37	11	102663349	102663349	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:102663349G>A	uc001phi.2	-	7	1163	c.1020C>T	c.(1018-1020)GTC>GTT	p.V340V	uc001phh.1_Intron|MMP1_uc010ruv.1_Silent_p.V274V	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	340	Hemopexin-like 2.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TGAAAAACCGGACTTCATCTC	0.388000													30	156					0	0	0	0
CADM1	23705	broad.mit.edu	37	11	115047259	115047259	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:115047259T>C	uc001ppi.3	-	10	1393	c.1264A>G	c.(1264-1266)ACA>GCA	p.T422A	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Missense_Mutation_p.T394A|CADM1_uc001ppj.3_Missense_Mutation_p.T423A|CADM1_uc001pph.3_Missense_Mutation_p.T185A	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	422	Cytoplasmic (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ATTATAGCTGTGTCTGCGTCT	0.463000													61	145					0	0	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120350888	120350888	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:120350888G>A	uc001pxl.1	+	38	3993	c.3986G>A	c.(3985-3987)CGG>CAG	p.R1329Q	ARHGEF12_uc009zat.2_Missense_Mutation_p.R1310Q|ARHGEF12_uc009zau.1_Missense_Mutation_p.R1226Q	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1329					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TACAGTCCACGGACTTCAACT	0.448000			T	MLL	AML								40	166					0	0	0	0
ROBO4	54538	broad.mit.edu	37	11	124761403	124761403	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:124761403A>G	uc001qbg.2	-	12	1880	c.1740T>C	c.(1738-1740)ACT>ACC	p.T580T	ROBO4_uc010sas.1_Silent_p.T435T|ROBO4_uc001qbh.2_Silent_p.T470T|ROBO4_uc001qbi.2_Silent_p.T138T|ROBO4_uc010sat.1_Silent_p.T138T	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	580					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		AGCCATAAAAAGTGCTGGTGT	0.622000													17	55					0	0	0	0
CDON	50937	broad.mit.edu	37	11	125885306	125885306	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:125885306C>G	uc009zbw.2	-	7	1156	c.1028G>C	c.(1027-1029)TGT>TCT	p.C343S	CDON_uc001qdc.3_Missense_Mutation_p.C343S|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.C343S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	343	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		AAACCAGGTACAGTTGGGGGC	0.488000													11	85					0	0	0	0
ST14	6768	broad.mit.edu	37	11	130060396	130060396	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:130060396T>A	uc001qfw.2	+	7	875	c.682T>A	c.(682-684)TTC>ATC	p.F228I	ST14_uc010sca.1_Missense_Mutation_p.F38I	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	228	Extracellular (Potential).|CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCTGATGCGCTTCACCACGCC	0.697000													9	67					0	0	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48141546	48141546	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:48141546G>T	uc009zkp.2	-	13	1736	c.1296C>A	c.(1294-1296)GCC>GCA	p.A432A	RAPGEF3_uc001rpx.2_5'Flank|RAPGEF3_uc010sln.1_5'UTR|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.A432A|RAPGEF3_uc001rpz.3_Silent_p.A474A|RAPGEF3_uc001rqa.2_5'UTR	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	432					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		AGCCATACAGGGCCACCCACT	0.657000													7	45					2.74318e-10	3.09551e-10	1	0
ANP32D	23519	broad.mit.edu	37	12	48866821	48866821	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:48866821T>A	uc010slt.1	+	1	374	c.374T>A	c.(373-375)GTA>GAA	p.V125E		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	125	LRR 5.									ovary(1)|central_nervous_system(1)	2						ACTTGCGAGGTAACCAACCTG	0.448000													18	95					0	0	0	0
SLC4A8	9498	broad.mit.edu	37	12	51834519	51834519	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:51834519C>T	uc001rys.1	+	2	254	c.76C>T	c.(76-78)CAG>TAG	p.Q26*	SLC4A8_uc010sni.1_5'UTR|SLC4A8_uc001rym.2_5'UTR|SLC4A8_uc001ryn.2_5'UTR|SLC4A8_uc001ryo.2_5'UTR|SLC4A8_uc001ryp.1_5'UTR|SLC4A8_uc010snj.1_Nonsense_Mutation_p.Q53*|SLC4A8_uc001ryq.3_Nonsense_Mutation_p.Q26*|SLC4A8_uc001ryr.2_Nonsense_Mutation_p.Q26*|SLC4A8_uc010snk.1_5'UTR	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	26	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGTGGTGGATCAGGGTGGGAC	0.428000													22	83					0	0	0	0
FIGNL2	401720	broad.mit.edu	37	12	52215791	52215791	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:52215791G>C	uc001rzc.2	-	1	418	c.407C>G	c.(406-408)GCC>GGC	p.A136G		NM_001013690	NP_001013712	A6NMB9	FIGL2_HUMAN	fidgetin-like 2	136	Gly-rich.						ATP binding|nucleoside-triphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(357;0.135)		GAGGTTCCCGGCTAAAACTGG	0.731000													3	13					0	0	0	0
MON2	23041	broad.mit.edu	37	12	62892803	62892803	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:62892803G>T	uc001sre.2	+	5	931	c.540G>T	c.(538-540)ATG>ATT	p.M180I	MON2_uc009zqj.2_Missense_Mutation_p.M180I|MON2_uc010ssl.1_Missense_Mutation_p.M108I|MON2_uc010ssm.1_Missense_Mutation_p.M180I|MON2_uc010ssn.1_Missense_Mutation_p.M180I|MON2_uc001srf.2_5'Flank|MON2_uc001srd.1_Missense_Mutation_p.M72I	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	180					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTGAGAGGATGGTTGCTGAAG	0.378000													102	297					6.84326e-50	9.12434e-50	1	0
C12orf66	144577	broad.mit.edu	37	12	64588097	64588097	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:64588097G>A	uc001srw.3	-	3	922	c.863C>T	c.(862-864)ACG>ATG	p.T288M	C12orf66_uc009zql.2_Missense_Mutation_p.T235M	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	288										ovary(1)	1						TGCTGTCAACGTTTTCATTTC	0.393000													49	161					0	0	0	0
GRIP1	23426	broad.mit.edu	37	12	66788009	66788009	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:66788009G>C	uc001stk.2	-	16	2193	c.1952C>G	c.(1951-1953)ACT>AGT	p.T651S	GRIP1_uc010sta.1_Missense_Mutation_p.T595S|GRIP1_uc001stj.2_Missense_Mutation_p.T433S|GRIP1_uc001stl.1_Missense_Mutation_p.T543S|GRIP1_uc001stm.2_Missense_Mutation_p.T651S	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	703	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCCCCCTTTAGTGAGGCTTGA	0.433000													67	192					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	73056937	73056937	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:73056937G>T	uc001sxa.2	+	19	3067	c.3037G>T	c.(3037-3039)GAG>TAG	p.E1013*		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1013	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTACCAAGACGAGCTTTTCCA	0.393000													21	65					4.4004e-07	4.81111e-07	1	0
TRHDE	29953	broad.mit.edu	37	12	73056946	73056946	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:73056946C>A	uc001sxa.2	+	19	3076	c.3046C>A	c.(3046-3048)CAA>AAA	p.Q1016K		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1016	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CGAGCTTTTCCAATGGTTAGG	0.398000													18	58					1.00905e-13	1.17364e-13	1	0
NAV3	89795	broad.mit.edu	37	12	78593221	78593221	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:78593221G>T	uc001syp.2	+	37	6798	c.6625G>T	c.(6625-6627)GAC>TAC	p.D2209Y	NAV3_uc001syo.2_Missense_Mutation_p.D2187Y|NAV3_uc010sub.1_Missense_Mutation_p.D1666Y|NAV3_uc009zsf.2_Missense_Mutation_p.D1018Y	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2209						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCGCAATAATGACCTAGTCAA	0.368000										HNSCC(70;0.22)			35	111					1.42033e-22	1.78266e-22	1	0
TMTC3	160418	broad.mit.edu	37	12	88589095	88589095	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:88589095A>G	uc001tau.2	+	14	2634	c.2414A>G	c.(2413-2415)GAA>GGA	p.E805G		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	806						integral to membrane	binding			skin(1)	1						CCACATGAAGAATATATTCAG	0.348000													57	125					0	0	0	0
C12orf63	374467	broad.mit.edu	37	12	97137303	97137303	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:97137303A>G	uc001tet.1	+	20	2696	c.2618A>G	c.(2617-2619)AAG>AGG	p.K873R		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	873										skin(6)|ovary(1)	7						CTACAAGAAAAGCATTTAAAG	0.433000													3	135					0	0	0	0
ANKS1B	56899	broad.mit.edu	37	12	99194841	99194842	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:99194841_99194842GG>TT	uc001tge.1	-	20	3545_3546	c.3128_3129CC>AA	c.(3127-3129)ACC>AAA	p.T1043K	ANKS1B_uc001tgf.1_Missense_Mutation_p.T559K|ANKS1B_uc001tgk.2_Missense_Mutation_p.T340K|ANKS1B_uc010svd.1_Missense_Mutation_p.T49K|ANKS1B_uc001tgd.1_Missense_Mutation_p.T209K|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_Missense_Mutation_p.T73K|ANKS1B_uc001tgh.3_Missense_Mutation_p.T49K|ANKS1B_uc001tgi.2_Missense_Mutation_p.T293K|ANKS1B_uc009ztr.2_Missense_Mutation_p.T233K|ANKS1B_uc001tgj.2_Missense_Mutation_p.T209K|ANKS1B_uc009ztp.2_Missense_Mutation_p.T74K|ANKS1B_uc010svf.1_Missense_Mutation_p.T73K|ANKS1B_uc001tgg.3_Missense_Mutation_p.T141K|ANKS1B_uc010svg.1_Missense_Mutation_p.T178K|ANKS1B_uc009zts.1_Missense_Mutation_p.T269K	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	1043						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ACTGTACCGGGGTAGAGGCTGT	0.460000													7	14					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102043145	102043145	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:102043145C>A	uc001tii.2	+	13	1331	c.1229C>A	c.(1228-1230)GCT>GAT	p.A410D	MYBPC1_uc001tif.1_Missense_Mutation_p.A423D|MYBPC1_uc001tig.2_Missense_Mutation_p.A435D|MYBPC1_uc010svq.1_Missense_Mutation_p.A397D|MYBPC1_uc001tih.2_Missense_Mutation_p.A435D|MYBPC1_uc001tij.2_Missense_Mutation_p.A410D|MYBPC1_uc010svr.1_Missense_Mutation_p.A410D|MYBPC1_uc010svs.1_Missense_Mutation_p.A410D|MYBPC1_uc010svt.1_Missense_Mutation_p.A398D|MYBPC1_uc010svu.1_Missense_Mutation_p.A391D|MYBPC1_uc001tik.2_Missense_Mutation_p.A384D	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	410	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AAGGCTGATGCTGCAGAATAT	0.393000													26	176					1.56442e-22	1.95851e-22	1	0
CUX2	23316	broad.mit.edu	37	12	111747976	111747976	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:111747976C>A	uc001tsa.1	+	15	1543	c.1390C>A	c.(1390-1392)CTG>ATG	p.L464M		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	464	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCAGCCCCTGCTGGGCCCCAG	0.687000													7	18					0.000274275	0.000288341	1	0
TPCN1	53373	broad.mit.edu	37	12	113730845	113730845	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:113730845G>T	uc001tuw.2	+	26	2517	c.2220G>T	c.(2218-2220)CTG>CTT	p.L740L	TPCN1_uc001tux.2_Silent_p.L812L|TPCN1_uc010syu.1_5'Flank	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	740	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCACCAGGCTGCTGGAGACCC	0.612000													12	40					5.50884e-06	5.91779e-06	1	0
COX6A1	1337	broad.mit.edu	37	12	120876216	120876216	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:120876216G>T	uc001tyf.1	+	2	164	c.138G>T	c.(136-138)GCG>GCT	p.A46A		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	46					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTTCGTCGCGCTCCCCGGGG	0.627000													38	100					2.75727e-19	3.38299e-19	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184858	130184858	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:130184858G>T	uc009zyl.1	-	2	793	c.465C>A	c.(463-465)GAC>GAA	p.D155E		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	155	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGTCGTCCCAGTCTCTGCCCA	0.602000													15	28					1.05317e-09	1.18032e-09	1	0
PXMP2	5827	broad.mit.edu	37	12	133266848	133266848	+	Splice_Site	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:133266848G>A	uc001ukt.2	+	2	188	c.123_splice	c.e2-1	p.S41_splice	POLE_uc001uks.1_5'Flank|POLE_uc010tbq.1_5'Flank|POLE_uc009zyu.1_5'Flank|PGAM5_uc010tbr.1_Splice_Site	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa							integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CCTCTCCACAGTGGCATTTTG	0.517000													38	113					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19415742	19415742	+	RNA	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:19415742T>C	uc010tcj.1	-	1		c.30368A>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GCTGTTTTCCTAATCTTTCTT	0.313000													3	72					0	0	0	0
ATP12A	479	broad.mit.edu	37	13	25265203	25265203	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:25265203G>T	uc001upp.2	+	8	1070	c.883G>T	c.(883-885)GAG>TAG	p.E295*	ATP12A_uc010aaa.2_Nonsense_Mutation_p.E301*	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	295	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGTTGGAAATGAGAAGACGCC	0.517000													36	76					2.75727e-19	3.38299e-19	1	0
CCNA1	8900	broad.mit.edu	37	13	37015288	37015288	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:37015288C>G	uc001uvr.3	+	7	1482	c.1132C>G	c.(1132-1134)CCA>GCA	p.P378A	CCNA1_uc010teo.1_Missense_Mutation_p.P334A|CCNA1_uc010abq.2_Missense_Mutation_p.P334A|CCNA1_uc010abp.2_Missense_Mutation_p.P334A|CCNA1_uc001uvs.3_Missense_Mutation_p.P377A|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	378					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TGAAGCAGATCCATTCTTGAA	0.398000													41	70					0	0	0	0
ZIC2	7546	broad.mit.edu	37	13	100637292	100637292	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:100637292G>A	uc001von.2	+	2	1168	c.1168G>A	c.(1168-1170)GAT>AAT	p.D390N		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	390					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCACACCTCCGATAAGCCCTA	0.627000													47	48					0	0	0	0
OR11H12	440153	broad.mit.edu	37	14	19377681	19377681	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:19377681C>A	uc010tkp.1	+	1	88	c.88C>A	c.(88-90)CAA>AAA	p.Q30K		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	30	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTATACTCCAAGGTTTCAC	0.413000													70	187					7.07328e-35	9.18221e-35	1	0
POTEG	404785	broad.mit.edu	37	14	19553736	19553736	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:19553736C>A	uc001vuz.1	+	1	372	c.320C>A	c.(319-321)CCC>CAC	p.P107H	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	107										ovary(1)	1						CACTGCTTCCCCTGCTGCAGG	0.602000													23	591					3.03874e-20	3.7754e-20	1	0
OR4L1	122742	broad.mit.edu	37	14	20528872	20528872	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:20528872C>A	uc001vwn.1	+	1	669	c.669C>A	c.(667-669)GTC>GTA	p.V223V		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCATCCTGGTCAGTGTACCAA	0.438000													58	180					2.41709e-19	2.98047e-19	1	0
CHD8	57680	broad.mit.edu	37	14	21863125	21863125	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:21863125C>A	uc001was.1	-	30	4593	c.4499G>T	c.(4498-4500)CGT>CTT	p.R1500L	CHD8_uc001war.1_Missense_Mutation_p.R1396L|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1779					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TGCTTCACAACGCCGCCTTCG	0.498000													30	55					3.99451e-17	4.78175e-17	1	0
CMTM5	116173	broad.mit.edu	37	14	23846490	23846490	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:23846490G>A	uc010akm.2	+	1	474	c.30G>A	c.(28-30)CGG>CGA	p.R10R	CMTM5_uc001wjs.2_Silent_p.R10R|CMTM5_uc001wjt.2_Silent_p.R10R|CMTM5_uc010akn.2_Silent_p.R10R|CMTM5_uc001wju.2_Silent_p.R10R|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	10					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GCCGGGACCGGCACCCTGAGG	0.602000													4	161					0	0	0	0
MIPOL1	145282	broad.mit.edu	37	14	37777652	37777652	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:37777652G>A	uc001wuc.2	+	10	1259	c.756G>A	c.(754-756)AAG>AAA	p.K252K	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Silent_p.K221K|MIPOL1_uc001wud.2_Silent_p.K252K|MIPOL1_uc010ams.2_Silent_p.K252K|MIPOL1_uc001wue.2_Silent_p.K221K|MIPOL1_uc010amt.2_Silent_p.K71K	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	252										ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		ACAAGACCAAGGAATGTAAAA	0.368000													46	138					0	0	0	0
KTN1	3895	broad.mit.edu	37	14	56114744	56114744	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:56114744A>C	uc001xcb.2	+	21	2511	c.2209A>C	c.(2209-2211)ATT>CTT	p.I737L	KTN1_uc001xce.2_Missense_Mutation_p.I737L|KTN1_uc001xcc.2_Missense_Mutation_p.I737L|KTN1_uc001xcd.2_Missense_Mutation_p.I737L|KTN1_uc010trb.1_Missense_Mutation_p.I737L|KTN1_uc001xcf.1_Missense_Mutation_p.I737L|KTN1_uc010aoq.2_Missense_Mutation_p.I32L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	737	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TAATTTCAGCATTCAAGAAAA	0.229000			T	RET	papillary thryoid								10	63					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64630120	64630120	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:64630120G>C	uc001xgm.2	+	89	16530	c.16300G>C	c.(16300-16302)GAG>CAG	p.E5434Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E5434Q|SYNE2_uc010apy.2_Missense_Mutation_p.E1819Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E396Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5434	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCTTCTGCAGGAGCTGCAGCA	0.493000													25	86					0	0	0	0
C14orf166B	145497	broad.mit.edu	37	14	77327047	77327047	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:77327047G>T	uc001xsx.2	+	11	1230	c.1116G>T	c.(1114-1116)GTG>GTT	p.V372V	C14orf166B_uc010asn.1_Silent_p.V132V|C14orf166B_uc001xsw.2_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	372											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		ACGTGCTGGTGTCCGAGCAGT	0.577000													16	73					1.02788e-11	1.17883e-11	1	0
PRIMA1	145270	broad.mit.edu	37	14	94187810	94187810	+	Missense_Mutation	SNP	C	T	T	rs140016687		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:94187810C>T	uc001ybw.1	-	5	484	c.442G>A	c.(442-444)GTG>ATG	p.V148M	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	148	Cytoplasmic (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GCGTTGTTCACGTCTACTCCT	0.572000													13	55					0	0	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033433	95033433	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:95033433G>A	uc001ydk.2	+	3	842	c.776G>A	c.(775-777)AGA>AAA	p.R259K	SERPINA4_uc010avd.2_Missense_Mutation_p.R296K|SERPINA4_uc001ydl.2_Missense_Mutation_p.R259K	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	259					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CTTCATGACAGATACTTGCCC	0.488000													30	74					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	107078600	107078600	+	RNA	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:107078600T>A	uc010tyt.1	-	117		c.5690A>T								Parts of antibodies, mostly variable regions.												0						CCAGAAGCCTTGCAGGAGACC	0.572000													33	85					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	107183662	107183662	+	RNA	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:107183662G>T	uc010tyt.1	-	29		c.1895C>A								Parts of antibodies, mostly variable regions.												0						CCCCAGGCTGGACCAAGCCTC	0.587000													6	147					5.68852e-11	6.46364e-11	1	0
Unknown	0	broad.mit.edu	37	15	20495401	20495401	+	RNA	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:20495401G>A	uc001ytf.1	+	5		c.604G>A								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		AAGATCTTCTGTGTGAGGAAA	0.403000													8	143					0	0	0	0
GOLGA9P	283796	broad.mit.edu	37	15	23261823	23261823	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:23261823G>T	uc001yvh.1	+	11	1234	c.692G>T	c.(691-693)AGG>ATG	p.R231M	uc001yvl.2_5'Flank	NR_024074				RecName: Full=Putative golgin subfamily A member 6-like protein 11;												0						CAGCACCTGAGGAAGGAACTA	0.577000													5	144					2.0095e-06	2.1634e-06	1	0
MKRN3	7681	broad.mit.edu	37	15	23811560	23811561	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:23811560_23811561CC>AA	uc001ywh.3	+	1	1107_1108	c.631_632CC>AA	c.(631-633)CCC>AAC	p.P211N	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.P211N	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	211						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCCAGGGCAGCCCTACCGGGGC	0.599000													12	46					0	0	0	0
GABRB3	2562	broad.mit.edu	37	15	26806266	26806266	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:26806266G>T	uc001zaz.2	-	8	1035	c.893C>A	c.(892-894)CCC>CAC	p.P298H	GABRB3_uc010uae.1_Missense_Mutation_p.P213H|GABRB3_uc001zba.2_Missense_Mutation_p.P298H|GABRB3_uc001zbb.2_Missense_Mutation_p.P354H	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	298					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGGGATTTTGGGCAAGGTCTC	0.468000													34	125					2.42023e-17	2.91138e-17	1	0
FSIP1	161835	broad.mit.edu	37	15	39909940	39909940	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:39909940T>C	uc001zki.2	-	11	1913	c.1695A>G	c.(1693-1695)ATA>ATG	p.I565M		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	565										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CCTCACCTGCTATTGTATTCT	0.388000													60	143					0	0	0	0
CATSPER2	117155	broad.mit.edu	37	15	43927951	43927951	+	Silent	SNP	G	A	A	rs144799666		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:43927951G>A	uc001zsh.2	-	9	1310	c.1095C>T	c.(1093-1095)GAC>GAT	p.D365D	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.D365D|CATSPER2_uc001zsj.2_Silent_p.D365D	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	365	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTTGAACATGTCAGCTTTGA	0.488000													21	45					0	0	0	0
SPG11	80208	broad.mit.edu	37	15	44941067	44941067	+	Silent	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:44941067T>A	uc001ztx.2	-	7	1630	c.1599A>T	c.(1597-1599)CTA>CTT	p.L533L	SPG11_uc010ueh.1_Silent_p.L533L|SPG11_uc010uei.1_Silent_p.L533L|SPG11_uc001zua.1_Silent_p.L533L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	533	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CTGTTACCTCTAGTGCATGTA	0.363000													47	108					0	0	0	0
SLC28A2	9153	broad.mit.edu	37	15	45557355	45557355	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:45557355T>A	uc001zva.2	+	8	836	c.771T>A	c.(769-771)TTT>TTA	p.F257L		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	257					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AGGATGTCTTTGCTTTTCAGG	0.438000													9	246					0	0	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302916	58302916	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:58302916C>T	uc002aex.2	-	4	482	c.424G>A	c.(424-426)GGC>AGC	p.G142S	ALDH1A2_uc002aey.2_Missense_Mutation_p.G142S|ALDH1A2_uc010ugv.1_Missense_Mutation_p.G121S|ALDH1A2_uc010ugw.1_Missense_Mutation_p.G113S|ALDH1A2_uc002aew.2_Missense_Mutation_p.G46S	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTGATGACGCCCTGCAAATCC	0.433000													36	95					0	0	0	0
WDR73	84942	broad.mit.edu	37	15	85197483	85197483	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:85197483A>T	uc002bkw.2	-	1	39	c.23T>A	c.(22-24)CTG>CAG	p.L8Q	WDR73_uc002bkv.2_5'Flank|WDR73_uc002bkx.2_RNA|WDR73_uc010upa.1_Missense_Mutation_p.L8Q	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	8											0						GGATTCCACCAGCCAGTCGTC	0.677000													34	136					0	0	0	0
NTRK3	4916	broad.mit.edu	37	15	88472661	88472661	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:88472661G>A	uc002bme.1	-	16	2056	c.1894C>T	c.(1894-1896)CAT>TAT	p.H632Y	NTRK3_uc002bmh.2_Missense_Mutation_p.H624Y|NTRK3_uc002bmf.1_Missense_Mutation_p.H632Y|NTRK3_uc010upl.1_Missense_Mutation_p.H534Y|NTRK3_uc010bnh.1_Missense_Mutation_p.H624Y	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	632	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTGGCCCATGGGCCCTGCAA	0.488000			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			10	34					0	0	0	0
HBA2	3040	broad.mit.edu	37	16	223546	223546	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:223546C>A	uc002cfv.3	+	3	442	c.376C>A	c.(376-378)CTG>ATG	p.L126M	HBA2_uc002cfw.2_Intron	NM_000517	NP_000508	P69905	HBA_HUMAN	alpha 2 globin	126			L -> R (in Plasencia; family with moderate microcytosis and hypochromia).|L -> P (in Quong Sze; causes alpha- thalassemia).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	GCACGCCTCCCTGGACAAGTT	0.652000											OREG0003686	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	25					3.8784e-16	4.63149e-16	1	0
UBE2I	7329	broad.mit.edu	37	16	1374785	1374785	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:1374785G>T	uc002clc.1	+	7	572	c.468G>T	c.(466-468)GCG>GCT	p.A156A	UBE2I_uc002cld.1_Silent_p.A156A|UBE2I_uc002clf.1_Silent_p.A156A|UBE2I_uc002clg.1_Silent_p.A156A	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	156					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)				AGAAGTTTGCGCCCTCATAAG	0.473000													14	55					2.4624e-09	2.74716e-09	1	0
ZNF597	146434	broad.mit.edu	37	16	3487033	3487033	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:3487033G>A	uc002cvd.2	-	4	850	c.666C>T	c.(664-666)CGC>CGT	p.R222R		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	222	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGTGCTGGCGAAAGCTGG	0.473000													80	194					0	0	0	0
TFAP4	7023	broad.mit.edu	37	16	4310219	4310219	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:4310219G>A	uc010uxg.1	-	6	948	c.694C>T	c.(694-696)CAC>TAC	p.H232Y		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	232	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						ACCGTGGGGTGGTGGGTGGGG	0.617000													26	39					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9892263	9892263	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:9892263C>G	uc002czo.3	-	11	2775	c.2227G>C	c.(2227-2229)GAA>CAA	p.E743Q	GRIN2A_uc010uym.1_Missense_Mutation_p.E743Q|GRIN2A_uc010uyn.1_Missense_Mutation_p.E586Q|GRIN2A_uc002czr.3_Missense_Mutation_p.E743Q	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	743	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGCAGCCTTCATCCCTCCCA	0.537000													23	87					0	0	0	0
ACSM1	116285	broad.mit.edu	37	16	20682863	20682863	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:20682863A>G	uc002dhm.1	-	4	810	c.742T>C	c.(742-744)TTC>CTC	p.F248L	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.F248L	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	248					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						CTTCCTGGGAAGGAGGGTTGT	0.438000													36	76					0	0	0	0
EEF2K	29904	broad.mit.edu	37	16	22271842	22271842	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:22271842A>T	uc002dki.2	+	11	1776	c.1291A>T	c.(1291-1293)AAC>TAC	p.N431Y	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	431					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		TCATCTAGACAACCACCGGGT	0.547000													55	193					0	0	0	0
ITGAX	3687	broad.mit.edu	37	16	31373420	31373420	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:31373420G>A	uc002ebu.1	+	11	1178	c.1111G>A	c.(1111-1113)GGG>AGG	p.G371R	ITGAX_uc002ebt.2_Missense_Mutation_p.G371R|ITGAX_uc010vfk.1_Missense_Mutation_p.G21R	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	371	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGGGCTGTGGGGAGCTTCAC	0.567000													82	252					0	0	0	0
TSR1	55720	broad.mit.edu	37	17	2238908	2238908	+	Silent	SNP	C	T	T	rs139241652		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:2238908C>T	uc002fuj.2	-	3	1275	c.318G>A	c.(316-318)AGG>AGA	p.R106R	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	106					ribosome assembly	nucleolus	protein binding			ovary(1)	1						TTCCAGTGTCCCTATCTTGAA	0.542000													4	153					0	0	0	0
OR1D2	4991	broad.mit.edu	37	17	2995854	2995854	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:2995854G>A	uc010vrb.1	-	1	437	c.437C>T	c.(436-438)TCC>TTC	p.S146F		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	146	Helical; Name=4; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CCAACACAAGGAAAGGAGTAA	0.522000													38	50					0	0	0	0
ATP2A3	489	broad.mit.edu	37	17	3844430	3844430	+	Silent	SNP	C	T	T	rs139395876		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:3844430C>T	uc002fxb.1	-	14	2086	c.1935G>A	c.(1933-1935)ACG>ACA	p.T645T	ATP2A3_uc002fwx.1_Silent_p.T645T|ATP2A3_uc002fwy.1_Silent_p.T645T|ATP2A3_uc002fwz.1_Silent_p.T645T|ATP2A3_uc002fxa.1_Silent_p.T645T|ATP2A3_uc002fxc.1_Silent_p.T645T|ATP2A3_uc002fxd.1_Silent_p.T645T	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	645	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCACGTCTTCCGTGTCCCCAA	0.682000													14	86					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	36					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10429179	10429179	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:10429179T>A	uc010coi.2	-	31	4330	c.4202A>T	c.(4201-4203)CAG>CTG	p.Q1401L	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.Q1401L|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1401	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTGCAGCCGCTGGGCCAGCTT	0.473000													14	70					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11515024	11515024	+	Missense_Mutation	SNP	G	T	T	rs141141277		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:11515024G>T	uc002gne.2	+	4	899	c.831G>T	c.(829-831)ATG>ATT	p.M277I	DNAH9_uc002gnd.1_Missense_Mutation_p.M277I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	277	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGAGGGGCATGGCCAAGCTCC	0.443000													87	66					1.72036e-36	2.25111e-36	1	0
MAP2K3	5606	broad.mit.edu	37	17	21207776	21207776	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:21207776C>T	uc002gys.2	+	8	872	c.607C>T	c.(607-609)CAT>TAT	p.H203Y	MAP2K3_uc002gyt.2_Missense_Mutation_p.H174Y|MAP2K3_uc002gyu.2_Missense_Mutation_p.H174Y	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	203	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAAGGAGGGCCATGTGAAGAT	0.582000													12	108					0	0	0	0
C17orf63	55731	broad.mit.edu	37	17	27085474	27085474	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:27085474G>T	uc002hct.1	-	3	1770	c.1503C>A	c.(1501-1503)GGC>GGA	p.G501G	C17orf63_uc010wax.1_Silent_p.G501G|C17orf63_uc010way.1_Silent_p.G501G|C17orf63_uc002hcw.2_Silent_p.G373G	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	501										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			CCACTGGACCGCCCCCGGTCC	0.632000													34	67					6.00712e-18	7.29754e-18	1	0
GPR179	440435	broad.mit.edu	37	17	36483635	36483635	+	Silent	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:36483635T>A	uc002hpz.2	-	11	5838	c.5817A>T	c.(5815-5817)ACA>ACT	p.T1939T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1939	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGAATTCTTCTGTGTCTGCAG	0.498000													28	97					0	0	0	0
ERBB2	2064	broad.mit.edu	37	17	37879629	37879629	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:37879629G>T	uc002hso.2	+	17	2242	c.2004G>T	c.(2002-2004)GGG>GGT	p.G668G	ERBB2_uc002hsm.2_Silent_p.G638G|ERBB2_uc010cwa.2_Silent_p.G653G|ERBB2_uc002hsp.2_Silent_p.G471G|ERBB2_uc010cwb.2_Silent_p.G668G|ERBB2_uc010wek.1_Silent_p.G392G	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	668	Helical; (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGGTCTTGGGGGTGGTCTTTG	0.607000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			49	147					3.21987e-24	4.08293e-24	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39253804	39253804	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:39253804A>T	uc010wfo.1	-	1	572	c.533T>A	c.(532-534)GTG>GAG	p.V178E		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	178						keratin filament					0						GGCGCAGCACACGGGGCGGGG	0.547000													2	2					0	0	0	0
KRT33A	3883	broad.mit.edu	37	17	39502482	39502482	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:39502482G>A	uc002hwk.1	-	7	1141	c.1104C>T	c.(1102-1104)CCC>CCT	p.P368P		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	368	Tail.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				AGGGGTTGGAGGGGAGCCTGT	0.488000													12	129					0	0	0	0
CNTD1	124817	broad.mit.edu	37	17	40951132	40951132	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:40951132A>G	uc002ibm.3	+	1	279	c.47A>G	c.(46-48)CAG>CGG	p.Q16R	CCDC56_uc010wgz.1_5'Flank|CCDC56_uc002ibl.2_5'Flank|CNTD1_uc010wha.1_Intron	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	16										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GTTGACTTTCAGTTTGGAGTT	0.607000													3	70					0	0	0	0
RUNDC1	146923	broad.mit.edu	37	17	41141370	41141370	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:41141370G>C	uc002ici.1	+	3	682	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	RUNDC1_uc010whi.1_5'UTR	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	224	Potential.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GATCATAGATGAGTTAATAAA	0.433000													22	56					0	0	0	0
RUNDC1	146923	broad.mit.edu	37	17	41141510	41141510	+	Silent	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:41141510G>C	uc002ici.1	+	3	822	c.810G>C	c.(808-810)CTG>CTC	p.L270L	RUNDC1_uc010whi.1_Silent_p.L40L	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	270											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		TTGAGCAACTGAAAACTCAGA	0.478000													35	85					0	0	0	0
C17orf57	124989	broad.mit.edu	37	17	45481247	45481247	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:45481247T>A	uc002iln.2	+	19	2432	c.2021T>A	c.(2020-2022)TTA>TAA	p.L674*	C17orf57_uc002ilm.2_Nonsense_Mutation_p.L578*	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	674							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TTTATAGAGTTACAGGAAGTT	0.343000													34	115					0	0	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48601147	48601147	+	Splice_Site	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:48601147T>A	uc010wmr.1	+	12	1926	c.1764_splice	c.e12+2	p.E588_splice	MYCBPAP_uc002iqz.2_Splice_Site	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein						cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GTACTGGAGGTAAGGGACCCA	0.532000													15	49					0	0	0	0
MMD	23531	broad.mit.edu	37	17	53471830	53471830	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:53471830G>A	uc002iui.2	-	7	867	c.582C>T	c.(580-582)TTC>TTT	p.F194F		NM_012329	NP_036461	Q15546	PAQRB_HUMAN	monocyte to macrophage	194	Helical; (Potential).				cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity				0						CACTCTTGAAGAACACAACTC	0.453000													26	89					0	0	0	0
SEPT9	10801	broad.mit.edu	37	17	75488797	75488797	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:75488797G>C	uc002jts.3	+	9	1601	c.1475G>C	c.(1474-1476)CGG>CCG	p.R492P	SEPT9_uc010wtk.1_Missense_Mutation_p.R473P|SEPT9_uc002jtt.3_Missense_Mutation_p.R328P|SEPT9_uc002jtu.3_Missense_Mutation_p.R474P|SEPT9_uc002jtv.2_Missense_Mutation_p.R485P|SEPT9_uc002jtw.2_Missense_Mutation_p.R328P|SEPT9_uc010wtl.1_Missense_Mutation_p.R268P|SEPT9_uc002jty.3_Missense_Mutation_p.R241P|SEPT9_uc010wtm.1_Missense_Mutation_p.R241P|SEPT9_uc010wtn.1_Missense_Mutation_p.R241P|SEPT9_uc010dhd.2_Missense_Mutation_p.R380P	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	492					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			GAGAAGTTCCGGGTGAGTGGA	0.557000													59	170					0	0	0	0
RPTOR	57521	broad.mit.edu	37	17	78820280	78820280	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:78820280C>T	uc002jyt.1	+	11	2025	c.1220C>T	c.(1219-1221)CCG>CTG	p.P407L	RPTOR_uc010wuf.1_Missense_Mutation_p.P222L|RPTOR_uc010wug.1_Missense_Mutation_p.P407L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	407					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CAGCACAGCCCGTTCTTCGCC	0.632000													5	166					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	6980533	6980533	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:6980533T>A	uc002knm.2	-	42	6088	c.5994A>T	c.(5992-5994)AGA>AGT	p.R1998S	LAMA1_uc010wzj.1_Missense_Mutation_p.R1474S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1998	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGGAATTGCTCTAAGTATCA	0.373000													25	62					0	0	0	0
PTPRM	5797	broad.mit.edu	37	18	8069752	8069752	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:8069752G>C	uc002knn.3	+	8	1704	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	PTPRM_uc010dkv.2_Missense_Mutation_p.E401Q|PTPRM_uc010wzl.1_Missense_Mutation_p.E188Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	401	Fibronectin type-III 2.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TATCCGCTGGGAGCCATTTGG	0.418000													20	56					0	0	0	0
NPC1	4864	broad.mit.edu	37	18	21136302	21136302	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:21136302G>A	uc002kum.3	-	8	1505	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	NPC1_uc010xaz.1_Missense_Mutation_p.R212W|NPC1_uc010xba.1_Missense_Mutation_p.R256W	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	411					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAGGGGCCCGGATGATGAGC	0.552000													10	52					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22806498	22806498	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:22806498C>T	uc002kvk.2	-	4	1631	c.1384G>A	c.(1384-1386)GCT>ACT	p.A462T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.A462T|ZNF521_uc002kvl.2_Missense_Mutation_p.A242T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	462					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGGTCCTGAGCTTCATGCACT	0.463000			T	PAX5	ALL								22	53					0	0	0	0
CDH2	1000	broad.mit.edu	37	18	25585919	25585919	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:25585919C>T	uc002kwg.2	-	6	1200	c.741G>A	c.(739-741)GTG>GTA	p.V247V	CDH2_uc010xbn.1_Silent_p.V216V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	247	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TGGGGTTCTCCACTTGATTTC	0.368000													64	129					0	0	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093472	30093472	+	RNA	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:30093472A>G	uc010dmc.2	+	1		c.1847A>G				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						GGTAGATAATACAAGTGCAGC	0.532000													51	294					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50278744	50278744	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:50278744G>T	uc002lfe.1	+	2	999	c.412G>T	c.(412-414)GGA>TGA	p.G138*	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	138	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCAGTAGCAGGTAGGTGGAT	0.308000													20	50					6.33239e-15	7.43564e-15	1	0
CNDP1	84735	broad.mit.edu	37	18	72247436	72247436	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:72247436T>C	uc002llq.2	+	10	1449	c.1238T>C	c.(1237-1239)CTA>CCA	p.L413P	CNDP1_uc002lls.2_Missense_Mutation_p.L216P	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	413					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		TCCATGACTCTAGGACTACAC	0.423000													26	43					0	0	0	0
NFATC1	4772	broad.mit.edu	37	18	77246597	77246597	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:77246597C>T	uc010xfg.1	+	9	2895	c.2442C>T	c.(2440-2442)CCC>CCT	p.P814P	NFATC1_uc002lnd.2_Silent_p.P814P|NFATC1_uc002lne.2_Silent_p.P342P|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Silent_p.P342P|NFATC1_uc002lnf.2_Silent_p.P801P|NFATC1_uc002lng.2_Silent_p.P801P|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	814	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCGGCTCGCCCGGGCAGCCAC	0.751000													3	16					0	0	0	0
AP3D1	8943	broad.mit.edu	37	19	2109208	2109208	+	Splice_Site	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:2109208T>C	uc002luz.2	-	28	3388	c.3165_splice	c.e28-1	p.S1055_splice	AP3D1_uc010dsv.2_Splice_Site_p.S145_splice|AP3D1_uc002luy.2_Splice_Site_p.S1014_splice|AP3D1_uc002lva.2_Splice_Site_p.S1117_splice	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1						eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGCGTCACTGTGGGAGGGA	0.582000													72	167					0	0	0	0
DOT1L	84444	broad.mit.edu	37	19	2226522	2226522	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:2226522T>C	uc002lvb.3	+	27	4038	c.4002T>C	c.(4000-4002)GGT>GGC	p.G1334G	DOT1L_uc002lvc.1_Silent_p.G628G	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1334						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGTGATGGTGCTTCTCTTC	0.701000													6	55					0	0	0	0
PLIN4	729359	broad.mit.edu	37	19	4504669	4504669	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:4504669C>T	uc002mar.1	-	6	3876	c.3876G>A	c.(3874-3876)CGG>CGA	p.R1292R	PLIN4_uc010dub.1_Silent_p.R316R	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1292						lipid particle|plasma membrane					0						AGAGGCTGTGCCGCGCCCGCC	0.701000													3	6					0	0	0	0
EMR1	2015	broad.mit.edu	37	19	6913820	6913820	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:6913820G>T	uc002mfw.2	+	11	1317	c.1279G>T	c.(1279-1281)GCT>TCT	p.A427S	EMR1_uc010dvc.2_Missense_Mutation_p.A427S|EMR1_uc010dvb.2_Missense_Mutation_p.A375S|EMR1_uc010xji.1_Missense_Mutation_p.A286S|EMR1_uc010xjj.1_Missense_Mutation_p.A250S	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	427	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TATCACTCCGGCTGTTCGGAC	0.498000													52	188					7.37877e-41	9.68095e-41	1	0
KIAA1543	57662	broad.mit.edu	37	19	7676418	7676418	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:7676418C>T	uc002mgv.3	+	10	1240	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	KIAA1543_uc002mgu.3_Missense_Mutation_p.S407F	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	380					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CTGAAGTCTTCCCCGTCCATG	0.642000													4	49					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8138159	8138159	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:8138159C>A	uc002mjf.2	-	61	7746	c.7725G>T	c.(7723-7725)TCG>TCT	p.S2575S	FBN3_uc002mje.2_Silent_p.S371S	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2575	EGF-like 43; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGGTGGGGGGCGACAGGGCAC	0.657000													5	52					0.00116845	0.00120772	1	0
OR7D4	125958	broad.mit.edu	37	19	9324750	9324750	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:9324750C>A	uc002mla.1	-	1	764	c.764G>T	c.(763-765)GGA>GTA	p.G255V		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACCCCAAGTCCTGTTCCATA	0.537000													19	85					5.35267e-07	5.83927e-07	1	0
SMARCA4	6597	broad.mit.edu	37	19	11144078	11144078	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:11144078A>G	uc002mqf.3	+	26	3943	c.3659A>G	c.(3658-3660)TAC>TGC	p.Y1220C	SMARCA4_uc010dxp.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxo.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxq.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxr.2_Missense_Mutation_p.Y1220C|SMARCA4_uc002mqj.3_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxs.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxt.1_Missense_Mutation_p.Y440C|SMARCA4_uc002mqh.3_Missense_Mutation_p.Y343C|SMARCA4_uc002mqi.1_Missense_Mutation_p.Y423C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1220	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCAGCCAAGTACAAGCTCAAC	0.632000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				24	130					0	0	0	0
ZNF429	353088	broad.mit.edu	37	19	21720875	21720875	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:21720875G>T	uc002nqd.1	+	4	2157	c.2020G>T	c.(2020-2022)GGC>TGC	p.G674C	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						agaccgtcctggctaacatgg	0.020000													3	18					0.004672	0.00480884	1	0
ZNF43	7594	broad.mit.edu	37	19	21992324	21992324	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:21992324T>G	uc002nqj.2	-	4	645	c.515A>C	c.(514-516)AAA>ACA	p.K172T	ZNF43_uc010ecv.2_Missense_Mutation_p.K166T|ZNF43_uc002nql.2_Missense_Mutation_p.K166T|ZNF43_uc002nqm.2_Missense_Mutation_p.K166T|ZNF43_uc002nqk.2_Missense_Mutation_p.K102T	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTTGAAAAGTTTTTTTTCAGT	0.313000													4	61					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363959	22363959	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:22363959T>C	uc002nqs.1	-	3	878	c.560A>G	c.(559-561)TAT>TGT	p.Y187C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	187	C2H2-type 1; degenerate.			TLTYYKSI -> NLMEHKRV (in Ref. 2; BAC05174).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AATACTCTTATAATAAGTAAG	0.338000													28	158					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22939865	22939865	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:22939865T>C	uc010xrh.1	-	6	2466	c.2466A>G	c.(2464-2466)CTA>CTG	p.L822L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAGTATGAATTAGCTTATGTT	0.373000													27	147					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	31039729	31039729	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:31039729T>C	uc002nsu.1	+	4	3341	c.3203T>C	c.(3202-3204)ATG>ACG	p.M1068T	ZNF536_uc010edd.1_Missense_Mutation_p.M1068T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1068					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTCTCCAATATGATCAGCTCT	0.562000													24	108					0	0	0	0
GPI	2821	broad.mit.edu	37	19	34887334	34887334	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:34887334A>T	uc002nvg.1	+	13	1294	c.1191A>T	c.(1189-1191)CAA>CAT	p.Q397H	GPI_uc002nvf.2_Missense_Mutation_p.Q436H|GPI_uc010xrv.1_Missense_Mutation_p.Q408H|GPI_uc010xrw.1_Missense_Mutation_p.Q369H|GPI_uc010edl.1_Missense_Mutation_p.Q397H|GPI_uc002nvi.1_Missense_Mutation_p.Q60H	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	397					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					TCATCCACCAAGGTAGGCCCC	0.567000													44	108					0	0	0	0
FFAR1	2864	broad.mit.edu	37	19	35842987	35842987	+	Missense_Mutation	SNP	C	G	G	rs143187042		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:35842987C>G	uc002nzc.2	+	1	543	c.533C>G	c.(532-534)TCT>TGT	p.S178C		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	178	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GACCCGGCCTCTGCCGGCCCG	0.677000													11	70					0	0	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572979	38572979	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:38572979G>T	uc002ohk.2	+	3	1283	c.774G>T	c.(772-774)AAG>AAT	p.K258N		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	258					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCGGAGCCAAGGGGGACTCCC	0.721000													9	21					9.70103e-10	1.0897e-09	1	0
ZNF526	116115	broad.mit.edu	37	19	42730364	42730364	+	Silent	SNP	A	G	G	rs145952747		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:42730364A>G	uc002osz.1	+	3	1965	c.1809A>G	c.(1807-1809)CTA>CTG	p.L603L		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				CTTTGACGCTACAGCCTCCCA	0.617000													25	104					0	0	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473690	53473690	+	RNA	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:53473690A>G	uc002qan.3	-	4		c.811T>C				NR_003578				Synthetic construct DNA, clone: pF1KB9679, Homo sapiens ZNF702 gene for zinc finger protein 702, without stop codon, in Flexi system.												0						GGTTTTAGGAATACAAGAAAT	0.368000													8	59					0	0	0	0
MIR527	574497	broad.mit.edu	37	19	54257280	54257280	+	RNA	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:54257280T>C	hsa-mir-527|MI0003179	+			c.9T>C			MIR516A1_hsa-mir-516a-1|MI0003180_5'Flank																	0						GATCTCAAGCTGTGACTGCAA	0.428000													52	166					0	0	0	0
LILRB3	11025	broad.mit.edu	37	19	54723084	54723084	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:54723084C>G	uc002qef.1	-	8	1451	c.1340G>C	c.(1339-1341)GGG>GCG	p.G447A	LILRB3_uc002qee.1_Missense_Mutation_p.G447A|LILRB3_uc002qeh.1_Missense_Mutation_p.G447A|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.G447A|LILRA6_uc002qek.1_Missense_Mutation_p.G447A|LILRB3_uc010erh.1_Missense_Mutation_p.G464A|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.G447A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.G447A|LILRB3_uc002qep.1_Missense_Mutation_p.G447A|LILRB3_uc002qeq.1_Missense_Mutation_p.G447A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.G447A	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	447	Helical; (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity	p.G447R(1)		skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CACCGAGACCCCAATCAAAAC	0.343000													7	12					0	0	0	0
LILRA4	23547	broad.mit.edu	37	19	54849458	54849458	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:54849458G>C	uc002qfj.2	-	4	461	c.404C>G	c.(403-405)TCA>TGA	p.S135*	LILRA4_uc002qfi.2_Nonsense_Mutation_p.S69*	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	135	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GTTCACTCCTGAGGTCACCAC	0.582000													10	95					0	0	0	0
LILRP2	79166	broad.mit.edu	37	19	55224719	55224719	+	RNA	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:55224719T>C	uc002qgs.1	+	1		c.5119T>C			LILRP2_uc002qgt.1_RNA	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						GTCCCCAAGATGCAGCAAGGA	0.522000													9	12					0	0	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565248	58565248	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:58565248C>A	uc002qrc.1	+	6	1303	c.1056C>A	c.(1054-1056)CCC>CCA	p.P352P		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	352					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGAAAGCCCCCCGGAGCAAGG	0.662000													11	65					1.58986e-06	1.72294e-06	1	0
A1BG	1	broad.mit.edu	37	19	58864486	58864486	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:58864486G>A	uc002qsd.3	-	3	210	c.148C>T	c.(148-150)CAG>TAG	p.Q50*	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_Intron	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	50	Ig-like V-type 1.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		AGGTGGGCCTGGCACGTCAGC	0.592000													94	96					0	0	0	0
SOX11	6664	broad.mit.edu	37	2	5832931	5832931	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:5832931C>T	uc002qyj.2	+	1	133	c.78C>T	c.(76-78)TTC>TTT	p.F26F		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	26					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGGGCGAATTCATGGCTTGCA	0.657000													5	18					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15567910	15567910	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:15567910C>A	uc002rcc.1	-	22	2374	c.2348G>T	c.(2347-2349)GGT>GTT	p.G783V	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	783										ovary(2)|liver(1)|skin(1)	4						CAGGGAGTCACCGTTAAAACT	0.398000													6	27					0.00116845	0.00120772	1	0
AGBL5	60509	broad.mit.edu	37	2	27281352	27281352	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:27281352C>T	uc002rie.2	+	10	1973	c.1756C>T	c.(1756-1758)CTT>TTT	p.L586F	AGBL5_uc002rid.2_Missense_Mutation_p.L586F|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	586					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCACAGCAGCCTTACTAATCT	0.557000													47	115					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32770763	32770763	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:32770763G>T	uc010ezu.2	+	63	12780	c.12646G>T	c.(12646-12648)GTC>TTC	p.V4216F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4216					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TCCTTTCCACGTCCTTCGTAG	0.413000													92	286					1.11883e-47	1.48774e-47	1	0
SIX2	10736	broad.mit.edu	37	2	45233600	45233600	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:45233600A>G	uc002ruo.2	-	2	878	c.585T>C	c.(583-585)TCT>TCC	p.S195S	SIX2_uc002rup.2_Silent_p.S197S	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	195						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTGGCTGTTAGAATTGGAGT	0.587000													21	185					0	0	0	0
ALMS1	7840	broad.mit.edu	37	2	73747023	73747023	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:73747023A>G	uc002sje.1	+	13	9775	c.9664A>G	c.(9664-9666)AAT>GAT	p.N3222D	ALMS1_uc002sjf.1_Missense_Mutation_p.N3178D|ALMS1_uc002sjg.2_Missense_Mutation_p.N2608D|ALMS1_uc002sjh.1_Missense_Mutation_p.N2608D|ALMS1_uc010fev.1_Missense_Mutation_p.N37D	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3220					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GATTTTTATTAATGCTGAAGA	0.403000													28	179					0	0	0	0
NAT8B	51471	broad.mit.edu	37	2	73927774	73927774	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:73927774G>A	uc002sjk.1	-	3	694	c.659C>T	c.(658-660)CCT>CTT	p.P220L		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	220					gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						CTGAGCAGAAGGGAGGTGATA	0.358000													12	35					0	0	0	0
THNSL2	55258	broad.mit.edu	37	2	88482287	88482287	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:88482287T>A	uc002ssz.3	+	6	1025	c.872T>A	c.(871-873)ATC>AAC	p.I291N	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_Missense_Mutation_p.I291N|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Missense_Mutation_p.I133N|THNSL2_uc002ssy.3_Missense_Mutation_p.I291N|THNSL2_uc010fhe.2_Missense_Mutation_p.I133N	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	291					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						AATGACATCATCCACAGGACT	0.507000													31	98					0	0	0	0
LYG1	129530	broad.mit.edu	37	2	99909015	99909015	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:99909015G>T	uc002szy.2	-	4	382	c.132C>A	c.(130-132)CAC>CAA	p.H44Q	MRPL30_uc002szl.1_Intron|LYG1_uc010yvo.1_Missense_Mutation_p.H44Q	NM_174898	NP_777558	Q8N1E2	LYG1_HUMAN	lysozyme g-like protein 1 precursor	44					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity				0						AGTTCAGGCCGTGACGTCTTC	0.517000													26	115					2.41591e-17	2.91138e-17	1	0
MFSD9	84804	broad.mit.edu	37	2	103335339	103335339	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:103335339C>T	uc002tcb.2	-	6	1033	c.965G>A	c.(964-966)GGC>GAC	p.G322D	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	322					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GATGAGGTAGCCTGTCACCTT	0.607000													14	73					0	0	0	0
CYP27C1	339761	broad.mit.edu	37	2	127957114	127957114	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:127957114G>A	uc002tod.2	-	4	521	c.390C>T	c.(388-390)AGC>AGT	p.S130S		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	130						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		CATGAATTTGGCCTGTTTGAA	0.463000													23	31					0	0	0	0
R3HDM1	23518	broad.mit.edu	37	2	136374308	136374308	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:136374308A>C	uc002tuo.2	+	5	654	c.284A>C	c.(283-285)GAG>GCG	p.E95A	R3HDM1_uc010fni.2_Missense_Mutation_p.E93A|R3HDM1_uc002tup.2_Intron	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	95							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCTGCACCAGAGATATCACAG	0.368000													9	26					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141032117	141032117	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:141032117C>T	uc002tvj.1	-	85	13990	c.13018G>A	c.(13018-13020)GAT>AAT	p.D4340N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4340	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACACTTCCATCATCCCCAATG	0.403000										TSP Lung(27;0.18)			58	66					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141108504	141108504	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:141108504T>A	uc002tvj.1	-	77	12726	c.11754A>T	c.(11752-11754)GAA>GAT	p.E3918D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3918	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGAATTATGTTCAATATGAG	0.338000										TSP Lung(27;0.18)			107	120					0	0	0	0
TANC1	85461	broad.mit.edu	37	2	160084427	160084427	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:160084427T>A	uc002uag.2	+	25	4275	c.4001T>A	c.(4000-4002)TTA>TAA	p.L1334*	TANC1_uc010zcm.1_Nonsense_Mutation_p.L1326*|TANC1_uc010fom.1_Nonsense_Mutation_p.L1140*|TANC1_uc010fon.2_Nonsense_Mutation_p.L178*	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1334						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TTCAATGAATTAAGGGTTTCC	0.458000													72	65					0	0	0	0
KLHL23	151230	broad.mit.edu	37	2	170598005	170598005	+	Missense_Mutation	SNP	G	A	A	rs140221414		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:170598005G>A	uc002ufh.1	+	5	1662	c.1324G>A	c.(1324-1326)GAT>AAT	p.D442N	KLHL23_uc002ufi.1_Missense_Mutation_p.D442N	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	442	Kelch 4.										0						CTACAATTCCGATATCAACGA	0.433000													12	122					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179582426	179582426	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:179582426G>T	uc010zfg.1	-	84	21667	c.21443C>A	c.(21442-21444)TCT>TAT	p.S7148Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S3809Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8075							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGTACCAAGACACTTGAAG	0.413000													29	41					7.26314e-15	8.50825e-15	1	0
COL5A2	1290	broad.mit.edu	37	2	189927938	189927938	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:189927938T>A	uc002uqk.2	-	27	2104	c.1829A>T	c.(1828-1830)CAG>CTG	p.Q610L	COL5A2_uc010frx.2_Missense_Mutation_p.Q186L	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	610					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCTCCCGGGCTGCCCTCTGAT	0.527000													37	253					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196759837	196759837	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:196759837A>G	uc002utj.3	-	30	4860	c.4759T>C	c.(4759-4761)TTC>CTC	p.F1587L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1587	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCGGAAAAGAATGCAGTCATT	0.373000													45	60					0	0	0	0
MAP2	4133	broad.mit.edu	37	2	210558740	210558740	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:210558740G>C	uc002vde.1	+	7	2094	c.1846G>C	c.(1846-1848)GGT>CGT	p.G616R	MAP2_uc002vdc.1_Missense_Mutation_p.G616R|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.G612R	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	616					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GCATAAAAATGGTGACAAGGA	0.443000													30	65					0	0	0	0
UNC80	285175	broad.mit.edu	37	2	210640627	210640627	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:210640627G>A	uc010zjc.1	+	3	236	c.156G>A	c.(154-156)GTG>GTA	p.V52V	UNC80_uc002vdj.1_Silent_p.V52V	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	52						integral to membrane					0						TTGAGCGAGTGTTGGTAGAAA	0.368000													93	107					0	0	0	0
ABCA12	26154	broad.mit.edu	37	2	215891574	215891574	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:215891574C>T	uc002vew.2	-	10	1370	c.1150G>A	c.(1150-1152)GTG>ATG	p.V384M	ABCA12_uc002vev.2_Missense_Mutation_p.V66M|ABCA12_uc010zjn.1_Translation_Start_Site	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	384					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTGTCAGTCACATTTCTCACA	0.388000													104	217					0	0	0	0
SCG2	7857	broad.mit.edu	37	2	224462778	224462778	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:224462778C>G	uc002vnm.2	-	2	1356	c.1223G>C	c.(1222-1224)AGG>ACG	p.R408T		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	408					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGAGAGCATCCTATTTTGGAA	0.512000													67	70					0	0	0	0
DOCK10	55619	broad.mit.edu	37	2	225651808	225651808	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:225651808T>C	uc010fwz.1	-	50	5825	c.5586A>G	c.(5584-5586)AAA>AAG	p.K1862K	DOCK10_uc002vob.2_Silent_p.K1856K|DOCK10_uc002voa.2_Silent_p.K518K|DOCK10_uc002voc.2_Silent_p.K683K	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1862	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCTCTGCCACTTTCAGATATG	0.428000													82	87					0	0	0	0
AGFG1	3267	broad.mit.edu	37	2	228337216	228337216	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:228337216C>G	uc002vpc.2	+	1	329	c.79C>G	c.(79-81)CGA>GGA	p.R27G	AGFG1_uc002vpd.2_Missense_Mutation_p.R27G|AGFG1_uc002vpe.2_Missense_Mutation_p.R27G|AGFG1_uc002vpf.2_Missense_Mutation_p.R27G	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	27	Arf-GAP.				cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CCCGCACAACCGAAAGTGCTT	0.662000													13	11					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:29625885A>T	uc010ztl.1	+	2	71	c.39A>T	c.(37-39)AAA>AAT	p.K13N	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TCGCCCTGAAATCTGGCTATG	0.353000													4	160					0	0	0	0
BPI	671	broad.mit.edu	37	20	36954720	36954720	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:36954720C>A	uc002xib.2	+	10	1121	c.1059C>A	c.(1057-1059)ACC>ACA	p.T353T		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	353					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				CAGCCTCCACCCCGCCACACC	0.557000													22	33					5.45024e-15	6.4305e-15	1	0
ZNF334	55713	broad.mit.edu	37	20	45131697	45131697	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:45131697T>C	uc002xsc.2	-	5	465	c.281A>G	c.(280-282)GAT>GGT	p.D94G	ZNF334_uc002xsa.2_Missense_Mutation_p.D117G|ZNF334_uc002xsb.2_Missense_Mutation_p.D56G|ZNF334_uc002xsd.2_Missense_Mutation_p.D56G|ZNF334_uc010ghl.2_Missense_Mutation_p.D93G	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CAAATGTTTATCTTGGATTTC	0.338000													42	36					0	0	0	0
COL20A1	57642	broad.mit.edu	37	20	61943100	61943100	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:61943100C>A	uc011aau.1	+	13	1763	c.1663C>A	c.(1663-1665)CCC>ACC	p.P555T	COL20A1_uc011aav.1_Missense_Mutation_p.P376T	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	555					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGCCAGGACCCGTGAGTGCTC	0.692000													5	7					0.00116845	0.00120772	1	0
TPTE	7179	broad.mit.edu	37	21	10934071	10934071	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:10934071G>C	uc002yip.1	-	16	1274	c.906C>G	c.(904-906)ATC>ATG	p.I302M	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I284M|TPTE_uc002yir.1_Missense_Mutation_p.I264M|TPTE_uc010gkv.1_Missense_Mutation_p.I164M	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	302	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCAATCATGATTCTAACGA	0.313000													41	280					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10952935	10952935	+	Missense_Mutation	SNP	T	C	C	rs146617486	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:10952935T>C	uc002yip.1	-	9	630	c.262A>G	c.(262-264)ATT>GTT	p.I88V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I70V|TPTE_uc002yir.1_Missense_Mutation_p.I50V|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	88					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GATGATACAATTGAATGCACA	0.224000													19	154					0	0	0	0
BAGE2	85319	broad.mit.edu	37	21	11058268	11058268	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:11058268C>T	uc002yit.1	-	3	380	c.172G>A	c.(172-174)GTA>ATA	p.V58I	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCTGGGTACATTTCTCTTC	0.423000													7	317					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26422890	26422890	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:26422890C>A	uc003abz.1	+	43	7200	c.6950C>A	c.(6949-6951)GCT>GAT	p.A2317D	MYO18B_uc003aca.1_Missense_Mutation_p.A2198D|MYO18B_uc010guy.1_Missense_Mutation_p.A2199D|MYO18B_uc010guz.1_Missense_Mutation_p.A2197D|MYO18B_uc011aka.1_Missense_Mutation_p.A1471D|MYO18B_uc011akb.1_Missense_Mutation_p.A1830D|MYO18B_uc010gva.1_Missense_Mutation_p.A300D|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2317						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAGGGGCCGCTGGTGGTCTC	0.587000													24	68					1.66031e-10	1.87786e-10	1	0
SLC5A4	6527	broad.mit.edu	37	22	32625260	32625260	+	Missense_Mutation	SNP	C	T	T	rs144357030	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:32625260C>T	uc003ami.2	-	11	1203	c.1201G>A	c.(1201-1203)GCC>ACC	p.A401T		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	401	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						AGGGTGCTGGCGCTGTTGAAG	0.577000													58	145					0	0	0	0
CYTH4	27128	broad.mit.edu	37	22	37708147	37708147	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:37708147C>A	uc003arf.2	+	12	1160	c.1044C>A	c.(1042-1044)GGC>GGA	p.G348G	CYTH4_uc011amw.1_Silent_p.G291G|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	348	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TGGTGGAGGGCAAGCACGAAT	0.627000													13	65					0.000151284	0.000159383	1	0
APOBEC3D	140564	broad.mit.edu	37	22	39421332	39421332	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:39421332T>C	uc011aoe.1	+	3	522	c.468T>C	c.(466-468)CGT>CGC	p.R156R	APOBEC3D_uc011aod.1_Silent_p.R156R|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Silent_p.R156R|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	156					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					CAGGGGCCCGTGTGAAGATCA	0.592000													39	48					0	0	0	0
MGAT3	4248	broad.mit.edu	37	22	39883967	39883967	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:39883967G>A	uc003axv.3	+	2	854	c.615G>A	c.(613-615)CCG>CCA	p.P205P	MGAT3_uc010gxy.2_Silent_p.P205P	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	205	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					GGGAGGTGCCGCGCCGCGTCA	0.677000													6	16					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50656953	50656953	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:50656953C>T	uc003bkb.1	-	22	5430	c.4918G>A	c.(4918-4920)GCG>ACG	p.A1640T	TUBGCP6_uc003bka.1_Missense_Mutation_p.A727T|TUBGCP6_uc010har.1_Missense_Mutation_p.A1632T|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1640					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCCTTGAGCGCCCACATCATG	0.652000													14	75					0	0	0	0
CNTN4	152330	broad.mit.edu	37	3	2778011	2778011	+	Silent	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:2778011A>T	uc003bpc.2	+	4	389	c.168A>T	c.(166-168)CCA>CCT	p.P56P	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.P56P	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	56	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAGGAAATCCAAAACCTCATA	0.338000													32	105					0	0	0	0
WNT7A	7476	broad.mit.edu	37	3	13916474	13916474	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:13916474G>A	uc003bye.1	-	2	573	c.268C>T	c.(268-270)CGC>TGC	p.R90C		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	90					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						AAGACGGTGCGCTCTCCCAGT	0.582000													15	38					0	0	0	0
MYRIP	25924	broad.mit.edu	37	3	40275391	40275391	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:40275391C>A	uc003cka.2	+	12	2082	c.1947C>A	c.(1945-1947)GTC>GTA	p.V649V	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Intron|MYRIP_uc010hhw.2_Silent_p.V560V|MYRIP_uc011ayz.1_Silent_p.V462V|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	649	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CCACAGAAGTCCTGAAAGTCA	0.488000													26	81					3.01185e-09	3.33745e-09	1	0
STAB1	23166	broad.mit.edu	37	3	52558127	52558127	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:52558127T>C	uc003dej.2	+	68	7628	c.7554T>C	c.(7552-7554)GAT>GAC	p.D2518D	STAB1_uc003del.2_Silent_p.D430D	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2518	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGGAAGATGATGCTGATGACG	0.617000													38	236					0	0	0	0
FAM19A1	407738	broad.mit.edu	37	3	68055801	68055801	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:68055801T>C	uc003dnd.2	+	2	248	c.32T>C	c.(31-33)CTG>CCG	p.L11P	FAM19A1_uc003dne.2_Missense_Mutation_p.L11P|FAM19A1_uc003dng.2_Missense_Mutation_p.L11P|FAM19A1_uc003dnf.1_RNA	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	11						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		TCCTGGGTCCTGTATTTGTGG	0.522000													31	224					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433788	73433788	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:73433788G>A	uc003dpl.1	-	10	2025	c.1929C>T	c.(1927-1929)TGC>TGT	p.C643C	PDZRN3_uc011bgh.1_Silent_p.C300C|PDZRN3_uc010hoe.1_Silent_p.C341C|PDZRN3_uc011bgf.1_Silent_p.C360C|PDZRN3_uc011bgg.1_Silent_p.C363C	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	643							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGAAGCGCTCGCACTCGTCCA	0.657000													34	109					0	0	0	0
ROBO2	6092	broad.mit.edu	37	3	77089996	77089996	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:77089996T>A	uc003dpy.3	+	1	703	c.60T>A	c.(58-60)GAT>GAA	p.D20E	ROBO2_uc003dpz.2_Missense_Mutation_p.D20E|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D20E	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	20					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TTCGGGTTGATGGTAAGTTAA	0.363000													31	229					0	0	0	0
OR5K2	402135	broad.mit.edu	37	3	98217106	98217106	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:98217106C>T	uc011bgx.1	+	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						ACCCTTTCATCAATGAACTGG	0.353000													204	360					0	0	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133831	119133831	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:119133831C>T	uc003ecj.3	+	12	3587	c.3055C>T	c.(3055-3057)CCT>TCT	p.P1019S		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1019					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GGCAGAGGCTCCTCCCAACCA	0.592000													21	95					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124438313	124438313	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:124438313C>T	uc003ehg.2	+	60	9084	c.8957C>T	c.(8956-8958)ACG>ATG	p.T2986M	KALRN_uc003ehk.2_Missense_Mutation_p.T1289M	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2985					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AACCAAGGGACGTAGCCATCT	0.483000													32	48					0	0	0	0
LOC100125556	100125556	broad.mit.edu	37	3	125643874	125643874	+	RNA	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:125643874C>T	uc003eif.3	+	4		c.427C>T			LOC100125556_uc003eid.3_RNA|LOC100125556_uc003eie.3_Intron	NR_024251				Homo sapiens family with sequence similarity 86, member A pseudogene, mRNA (cDNA clone IMAGE:4425123).												0						GGCTGCCTGCCGGGAGCACCA	0.602000													18	74					0	0	0	0
SLC41A3	54946	broad.mit.edu	37	3	125735640	125735640	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:125735640C>T	uc003eij.2	-	7	1050	c.824G>A	c.(823-825)AGC>AAC	p.S275N	SLC41A3_uc003eii.2_Missense_Mutation_p.S249N|SLC41A3_uc003eil.2_Missense_Mutation_p.S275N|SLC41A3_uc003eik.2_Missense_Mutation_p.S239N|SLC41A3_uc011bkh.1_Missense_Mutation_p.S158N|SLC41A3_uc010hsd.1_Missense_Mutation_p.S290N	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	275						integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		GATGGGTGGGCTCTGCTTGGC	0.587000													4	122					0	0	0	0
CPNE4	131034	broad.mit.edu	37	3	131404769	131404769	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:131404769T>A	uc003eok.2	-	6	976	c.541A>T	c.(541-543)ATT>TTT	p.I181F	CPNE4_uc011blq.1_Missense_Mutation_p.I199F|CPNE4_uc003eol.2_Missense_Mutation_p.I199F|CPNE4_uc003eom.2_Missense_Mutation_p.I181F	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	181	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATACGAAAAATTTCCAGAAAT	0.383000													17	62					0	0	0	0
EPHB1	2047	broad.mit.edu	37	3	134851723	134851723	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:134851723G>C	uc003eqt.2	+	5	1349	c.1129G>C	c.(1129-1131)GTG>CTG	p.V377L	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	377	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGACGACAATGTGGAGTTTGT	0.617000													5	53					0	0	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123507	140123507	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:140123507T>C	uc003etn.2	+	4	726	c.536T>C	c.(535-537)CTG>CCG	p.L179P	CLSTN2_uc003etm.2_Missense_Mutation_p.L179P	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GACAGCATTCTGCAGGTGGAG	0.507000										HNSCC(16;0.037)			40	143					0	0	0	0
XRN1	54464	broad.mit.edu	37	3	142141448	142141448	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:142141448C>T	uc003eus.2	-	8	1010	c.943G>A	c.(943-945)GTT>ATT	p.V315I	XRN1_uc003eut.2_Missense_Mutation_p.V315I|XRN1_uc003euu.2_Missense_Mutation_p.V315I|XRN1_uc003euv.1_Missense_Mutation_p.V176I|XRN1_uc003euw.2_Missense_Mutation_p.V315I|XRN1_uc011bnh.1_Missense_Mutation_p.V105I	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	315					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						AGGATGGTAACATATGTTCCA	0.358000													74	128					0	0	0	0
ATR	545	broad.mit.edu	37	3	142217599	142217599	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:142217599A>T	uc003eux.3	-	32	5520	c.5398T>A	c.(5398-5400)TGG>AGG	p.W1800R		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1800	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTGACACTCCATGTTGTAGAT	0.378000								Other_conserved_DNA_damage_response_genes					36	65					0	0	0	0
PLOD2	5352	broad.mit.edu	37	3	145828169	145828169	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:145828169T>G	uc003evs.1	-	4	911	c.405A>C	c.(403-405)AAA>AAC	p.K135N	PLOD2_uc011bnm.1_Missense_Mutation_p.K80N|PLOD2_uc003evr.1_Missense_Mutation_p.K135N	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	135					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	CAAAGACCACTTTGTGGTTTG	0.388000													39	117					0	0	0	0
CPB1	1360	broad.mit.edu	37	3	148558763	148558763	+	Splice_Site	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:148558763G>T	uc003ewl.2	+	5	497	c.474_splice	c.e5+1	p.K158_splice		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein						proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCTCCTGAAGGTAATCATTTT	0.443000													24	121					5.35356e-11	6.09711e-11	1	0
DHX36	170506	broad.mit.edu	37	3	154013097	154013097	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154013097C>T	uc003ezy.3	-	13	1662	c.1581G>A	c.(1579-1581)CTG>CTA	p.L527L	DHX36_uc010hvq.2_Intron|DHX36_uc003ezz.3_Silent_p.L527L	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	527	Nuclear localization signal.|Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTGTAGGCATCAGTGAATGTA	0.303000													14	39					0	0	0	0
GPR149	344758	broad.mit.edu	37	3	154055728	154055728	+	Silent	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154055728T>A	uc003faa.2	-	4	2056	c.1956A>T	c.(1954-1956)CTA>CTT	p.L652L		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	652	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGAGTAACGTAGGGATGGAG	0.428000													77	251					0	0	0	0
MME	4311	broad.mit.edu	37	3	154859798	154859798	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154859798T>G	uc010hvr.1	+	11	1187	c.976T>G	c.(976-978)TTC>GTC	p.F326V	MME_uc003fab.1_Missense_Mutation_p.F326V|MME_uc003fac.1_Missense_Mutation_p.F326V|MME_uc003fad.1_Missense_Mutation_p.F326V|MME_uc003fae.1_Missense_Mutation_p.F326V	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	326	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGGTTGAATTTCACAAATGA	0.358000													58	133					0	0	0	0
RSRC1	51319	broad.mit.edu	37	3	158072664	158072664	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:158072664A>C	uc003fbt.2	+	6	661	c.550A>C	c.(550-552)AAA>CAA	p.K184Q	RSRC1_uc011bou.1_Missense_Mutation_p.K126Q|RSRC1_uc003fbu.1_Missense_Mutation_p.K184Q|RSRC1_uc003fbv.2_Missense_Mutation_p.K126Q	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	184	Potential.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			TGAACAGGCCAAAGCCAGACT	0.358000													6	30					0	0	0	0
PEX5L	51555	broad.mit.edu	37	3	179593166	179593166	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:179593166C>G	uc003fki.1	-	6	735	c.605G>C	c.(604-606)AGA>ACA	p.R202T	PEX5L_uc011bqd.1_Missense_Mutation_p.R159T|PEX5L_uc011bqe.1_Missense_Mutation_p.R10T|PEX5L_uc011bqf.1_Missense_Mutation_p.R94T|PEX5L_uc003fkj.1_Missense_Mutation_p.R167T|PEX5L_uc010hxd.1_Missense_Mutation_p.R200T|PEX5L_uc011bqg.1_Missense_Mutation_p.R178T|PEX5L_uc011bqh.1_Missense_Mutation_p.R143T	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	202					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TGATCCAGTTCTAGATGAGGA	0.378000													43	202					0	0	0	0
CRYGS	1427	broad.mit.edu	37	3	186257301	186257301	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:186257301C>T	uc003fqe.2	-	2	159	c.107G>A	c.(106-108)CGC>CAC	p.R36H	CRYGS_uc003fqf.2_Missense_Mutation_p.R36H	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	36	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GGAGTTGCAGCGACTTAGGTA	0.463000													38	138					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20550181	20550181	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:20550181T>A	uc003gpr.1	+	23	2620	c.2416T>A	c.(2416-2418)TTA>ATA	p.L806I	SLIT2_uc003gps.1_Missense_Mutation_p.L798I	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	806	LRR 19.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GCTCCTCACCTTGTGAGTGTG	0.284000													28	72					0	0	0	0
GBA3	57733	broad.mit.edu	37	4	22694648	22694648	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:22694648C>A	uc003gqp.3	+	1	101	c.10C>A	c.(10-12)CCT>ACT	p.P4T	GBA3_uc010iep.2_Missense_Mutation_p.P4T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	4					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						CATGGCTTTCCCTGCAGGATT	0.527000													5	13					1.23904e-05	1.32523e-05	1	0
PCDH7	5099	broad.mit.edu	37	4	31144302	31144302	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:31144302G>T	uc011bxx.1	+	3	4583	c.3575G>T	c.(3574-3576)CGC>CTC	p.R1192L	PCDH7_uc011bxw.1_Missense_Mutation_p.R1145L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						ATGGGTGACCGCAACAGAAAC	0.502000													18	139					1.56452e-12	1.81544e-12	1	0
SHISA3	152573	broad.mit.edu	37	4	42403085	42403085	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:42403085C>G	uc003gwp.2	+	2	552	c.334C>G	c.(334-336)CTG>GTG	p.L112V		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	112	Helical; (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GTTCATCATCCTGGGCTCTGT	0.502000													78	235					0	0	0	0
GRXCR1	389207	broad.mit.edu	37	4	42964954	42964954	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:42964954A>T	uc003gwt.2	+	2	430	c.430A>T	c.(430-432)ACC>TCC	p.T144S		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	144	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GATTTATACCACCTGCCTTCG	0.383000													58	250					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62897294	62897294	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:62897294T>C	uc010ihh.2	+	20	3526	c.3353T>C	c.(3352-3354)TTT>TCT	p.F1118S	LPHN3_uc003hcq.3_Missense_Mutation_p.F1118S|LPHN3_uc003hct.2_Missense_Mutation_p.F502S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1096	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CAGGGAATGTTTATATTTATT	0.348000													22	106					0	0	0	0
TIGD2	166815	broad.mit.edu	37	4	90034966	90034966	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:90034966A>C	uc003hsk.2	+	1	999	c.841A>C	c.(841-843)AAG>CAG	p.K281Q	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	281	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TTTGAAATCCAAGGGACTTTT	0.373000													21	89					0	0	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170592	90170592	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:90170592G>T	uc003hsm.1	-	2	1189	c.670C>A	c.(670-672)CAG>AAG	p.Q224K		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	224										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		ATGGCTCCCTGCCTTTCCCCT	0.537000													41	80					4.14481e-20	5.12373e-20	1	0
SEC24B	10427	broad.mit.edu	37	4	110445990	110445990	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:110445990G>A	uc003hzk.2	+	15	2580	c.2525G>A	c.(2524-2526)GGC>GAC	p.G842D	SEC24B_uc003hzl.2_Missense_Mutation_p.G807D|SEC24B_uc011cfp.1_Missense_Mutation_p.G872D|SEC24B_uc011cfq.1_Missense_Mutation_p.G841D|SEC24B_uc011cfr.1_Missense_Mutation_p.G806D	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	842					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAACATCTTGGCCCTGCAACT	0.358000													35	113					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114278087	114278087	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:114278087C>T	uc003ibe.3	+	38	8413	c.8313C>T	c.(8311-8313)ATC>ATT	p.I2771I	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.I73I|ANK2_uc011cgb.1_Silent_p.I2786I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2738					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCAAAAATCTGTGATGGCC	0.478000													21	86					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123113395	123113395	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123113395G>C	uc003ieh.2	+	9	958	c.913G>C	c.(913-915)GAA>CAA	p.E305Q	KIAA1109_uc003iei.1_Missense_Mutation_p.E59Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	305					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ACTTGTTCCGGAAGAAACAGA	0.318000													14	53					0	0	0	0
IL21	59067	broad.mit.edu	37	4	123542011	123542011	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123542011A>G	uc003ies.2	-	1	201	c.156T>C	c.(154-156)TAT>TAC	p.Y52Y	uc003iet.2_Intron|IL21_uc010int.2_Silent_p.Y45Y	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	45					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						AGTCATTCACATAATTTTTCA	0.343000													35	103					0	0	0	0
FGF2	2247	broad.mit.edu	37	4	123748456	123748456	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123748456A>T	uc003iev.1	+	1	594	c.526A>T	c.(526-528)ATC>TTC	p.I176F		NM_002006	NP_001997	P09038	FGF2_HUMAN	fibroblast growth factor 2	176					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|lung(1)|central_nervous_system(1)	3					Pentosan Polysulfate(DB00686)	CTTCCTGCGCATCCACCCCGA	0.667000													18	49					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126238150	126238150	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:126238150G>T	uc003ifj.3	+	1	584	c.584G>T	c.(583-585)GGC>GTC	p.G195V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	195	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AACCCGAGCGGCGAGGGAGCG	0.642000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	41					0.000673444	0.00070198	1	0
PCDH18	54510	broad.mit.edu	37	4	138452014	138452014	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:138452014G>A	uc003ihe.3	-	1	1616	c.1229C>T	c.(1228-1230)ACA>ATA	p.T410I	PCDH18_uc003ihf.3_Missense_Mutation_p.T403I|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.T190I|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	410	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GTTTTCATATGTCTTCTGAAG	0.393000													31	150					0	0	0	0
ELF2	1998	broad.mit.edu	37	4	139981705	139981705	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:139981705A>G	uc003ihp.1	-	8	1100	c.894T>C	c.(892-894)GAT>GAC	p.D298D	ELF2_uc003ihm.1_Silent_p.D250D|ELF2_uc003ihn.1_Silent_p.D238D|ELF2_uc003iho.1_Silent_p.D221D|ELF2_uc011chc.1_Silent_p.D113D	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	310					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					TTCCTGCTAAATCTTCATTAC	0.393000													48	211					0	0	0	0
ZNF330	27309	broad.mit.edu	37	4	142155086	142155086	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:142155086G>T	uc003iiq.3	+	10	1126	c.906G>T	c.(904-906)TTG>TTT	p.L302F	ZNF330_uc011chl.1_Missense_Mutation_p.L242F	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	302						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TTACTAATTTGAATTTAGGAA	0.338000													20	107					4.26978e-12	4.91974e-12	1	0
NR3C2	4306	broad.mit.edu	37	4	149357710	149357710	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:149357710T>C	uc003ilj.3	-	2	637	c.303A>G	c.(301-303)GTA>GTG	p.V101V	NR3C2_uc003ilk.3_Silent_p.V101V|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	101	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGGACTCAGCTACAGTTGCTG	0.408000													43	166					0	0	0	0
RNF175	285533	broad.mit.edu	37	4	154649396	154649396	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:154649396T>C	uc003int.2	-	4	737	c.364A>G	c.(364-366)AGA>GGA	p.R122G	RNF175_uc003inu.1_Intron	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	122						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CGGGTAGCTCTGAAGAGGATG	0.428000													30	69					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155156538	155156538	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155156538G>C	uc003inw.2	-	25	7901	c.7901C>G	c.(7900-7902)TCA>TGA	p.S2634*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2634					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACTGGAGTTTGAGTGTCTGTA	0.463000													45	94					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155156946	155156946	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155156946G>A	uc003inw.2	-	25	7493	c.7493C>T	c.(7492-7494)ACC>ATC	p.T2498I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2498	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CATTTCCAAGGTGTCTTCTTT	0.368000													40	151					0	0	0	0
LRAT	9227	broad.mit.edu	37	4	155665617	155665617	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155665617C>G	uc003iom.1	+	1	466	c.139C>G	c.(139-141)CGA>GGA	p.R47G	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R47G	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	47	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	CTCTTTCCACCGAGGCGACGT	0.577000													22	151					0	0	0	0
GLRB	2743	broad.mit.edu	37	4	158065104	158065104	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:158065104G>T	uc003ipj.2	+	8	1099	c.897G>T	c.(895-897)GTG>GTT	p.V299V		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	299	Helical; (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CTGCCAGAGTGCCCCTGGGTA	0.448000													19	142					6.33239e-15	7.43564e-15	1	0
GRIA2	2891	broad.mit.edu	37	4	158284070	158284070	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:158284070G>T	uc003ipm.3	+	15	2985	c.2526G>T	c.(2524-2526)GAG>GAT	p.E842D	GRIA2_uc011cit.1_Missense_Mutation_p.E795D|GRIA2_uc003ipl.3_Missense_Mutation_p.E842D|GRIA2_uc003ipk.3_Missense_Mutation_p.E795D|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	842	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CAAGGGCCGAGGCGAAACGAA	0.453000													47	84					2.13384e-23	2.69192e-23	1	0
FAM198B	51313	broad.mit.edu	37	4	159076818	159076818	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159076818G>A	uc003ipp.3	-	3	1522	c.1070C>T	c.(1069-1071)ACT>ATT	p.T357I	FAM198B_uc003ipq.3_Missense_Mutation_p.T365I|FAM198B_uc003ipr.3_Missense_Mutation_p.T357I	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	357	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ATGTATTTCAGTACAACCCGA	0.428000													4	73					0	0	0	0
FAM198B	51313	broad.mit.edu	37	4	159076833	159076833	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159076833G>C	uc003ipp.3	-	3	1507	c.1055C>G	c.(1054-1056)CCT>CGT	p.P352R	FAM198B_uc003ipq.3_Missense_Mutation_p.P360R|FAM198B_uc003ipr.3_Missense_Mutation_p.P352R	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	352	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ACCCGATTCAGGCTTGGGTAC	0.413000													5	72					0	0	0	0
TMEM144	55314	broad.mit.edu	37	4	159136355	159136355	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159136355A>G	uc003ipx.2	+	4	642	c.122A>G	c.(121-123)CAG>CGG	p.Q41R	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	41	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		ATGTTTCTCCAGTGGGTTCTT	0.388000													32	222					0	0	0	0
ANP32C	23520	broad.mit.edu	37	4	165118778	165118778	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:165118778G>T	uc011cjk.1	-	1	86	c.86C>A	c.(85-87)TCG>TAG	p.S29*	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	29											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GCCTTCATTCGACCGACTGTT	0.498000													68	310					1.74474e-33	2.25898e-33	1	0
GALNTL6	442117	broad.mit.edu	37	4	173852403	173852403	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:173852403G>T	uc003isv.2	+	9	1869	c.1133G>T	c.(1132-1134)GGG>GTG	p.G378V		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	378	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GTTCCATCTGGGACAAGCCTG	0.463000													53	125					6.4308e-24	8.13356e-24	1	0
WDR17	116966	broad.mit.edu	37	4	177052768	177052768	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:177052768C>T	uc003iuj.2	+	8	1205	c.1049C>T	c.(1048-1050)CCA>CTA	p.P350L	WDR17_uc003iuk.2_Missense_Mutation_p.P326L|WDR17_uc003ium.3_Missense_Mutation_p.P326L|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	350										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTTCCACCCCCAACTTTAACA	0.383000													82	230					0	0	0	0
WDR17	116966	broad.mit.edu	37	4	177098636	177098636	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:177098636C>A	uc003iuj.2	+	30	3836	c.3680C>A	c.(3679-3681)TCT>TAT	p.S1227Y	WDR17_uc003iuk.2_Missense_Mutation_p.S1203Y|WDR17_uc003ium.3_Missense_Mutation_p.S1188Y|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.S438Y	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1227										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTAGAAGACTCTCCGTATACA	0.299000													32	157					3.99451e-17	4.78175e-17	1	0
LRP2BP	55805	broad.mit.edu	37	4	186294193	186294193	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:186294193A>G	uc003ixj.1	-	6	1432	c.620T>C	c.(619-621)CTG>CCG	p.L207P	LRP2BP_uc003ixk.1_Missense_Mutation_p.L181P|LRP2BP_uc011ckr.1_Missense_Mutation_p.L207P	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	207	Sel1-like 4.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		CTGGGACTCCAGATTCCCATT	0.473000													23	85					0	0	0	0
TRIML1	339976	broad.mit.edu	37	4	189068081	189068081	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:189068081C>A	uc003izm.1	+	6	1077	c.962C>A	c.(961-963)CCG>CAG	p.P321Q	TRIML1_uc003izn.1_Missense_Mutation_p.P45Q	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	321	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCCGACAACCCGGAAAGATTT	0.537000													56	123					4.25531e-23	5.35451e-23	1	0
BRD9	65980	broad.mit.edu	37	5	884145	884145	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:884145C>T	uc003jbq.2	-	8	1041	c.874G>A	c.(874-876)GAC>AAC	p.D292N	BRD9_uc003jbl.2_Missense_Mutation_p.D176N|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.D239N|BRD9_uc003jbo.2_Missense_Mutation_p.D196N|BRD9_uc003jbp.2_5'Flank|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	292							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCGGTACTGTCCGTCAAGCTG	0.632000													23	75					0	0	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235236	5235236	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:5235236G>T	uc003jdl.2	+	13	2098	c.1960G>T	c.(1960-1962)GAG>TAG	p.E654*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.E654*|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCAGTGTGCCGAGCACAACAG	0.527000													10	119					1.58986e-06	1.72294e-06	1	0
FAM105B	90268	broad.mit.edu	37	5	14678802	14678802	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:14678802G>T	uc003jfk.2	+	3	394	c.242G>T	c.(241-243)AGC>ATC	p.S81I		NM_138348	NP_612357	Q96BN8	F105B_HUMAN	hypothetical protein LOC90268	81										ovary(2)	2	Lung NSC(4;0.00696)					CCGAGATTAAGCGTAGCTCCT	0.358000													9	36					2.17888e-05	2.32036e-05	1	0
PRDM9	56979	broad.mit.edu	37	5	23527819	23527819	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:23527819C>T	uc003jgo.2	+	11	2804	c.2622C>T	c.(2620-2622)AGC>AGT	p.S874S		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	874	C2H2-type 14.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATAGGTCAAGCCTCTGCTATC	0.522000										HNSCC(3;0.000094)			33	110					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26890582	26890582	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:26890582C>A	uc003jgs.1	-	8	1514	c.1345G>T	c.(1345-1347)GAA>TAA	p.E449*	CDH9_uc011cnv.1_Nonsense_Mutation_p.E42*	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	449	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GGAGATGATTCCCGGTCAAGG	0.408000													58	157					4.6707e-30	5.98433e-30	1	0
RAI14	26064	broad.mit.edu	37	5	34823760	34823760	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:34823760C>A	uc003jir.2	+	15	2009	c.1813C>A	c.(1813-1815)CAA>AAA	p.Q605K	RAI14_uc010iur.2_Missense_Mutation_p.Q576K|RAI14_uc011coj.1_Missense_Mutation_p.Q605K|RAI14_uc003jis.2_Missense_Mutation_p.Q608K|RAI14_uc003jit.2_Missense_Mutation_p.Q605K|RAI14_uc011cok.1_Missense_Mutation_p.Q597K	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	605	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CCAAGAAGCCCAAGAAGAAAT	0.363000													17	76					1.02788e-11	1.17883e-11	1	0
C5orf39	389289	broad.mit.edu	37	5	43040127	43040127	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:43040127A>T	uc003jnf.2	-	1	321	c.22T>A	c.(22-24)TGT>AGT	p.C8S	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	8							receptor activity				0						CGCTTCACACAGCCAAGAAAA	0.547000											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	117					0	0	0	0
CCNB1	891	broad.mit.edu	37	5	68473452	68473452	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:68473452G>A	uc003jvm.2	+	9	1473	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	CCNB1_uc010ixb.2_Silent_p.K395K	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	432					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CTGTGGCAAAGGTGTAACTTG	0.383000													22	140					0	0	0	0
PDE8B	8622	broad.mit.edu	37	5	76607880	76607880	+	Splice_Site	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:76607880T>A	uc003kfa.2	+	2	444	c.399_splice	c.e2+2	p.Q133_splice	PDE8B_uc003kfb.2_Intron|PDE8B_uc003kfc.2_Splice_Site_p.Q133_splice|PDE8B_uc003kfd.2_Splice_Site_p.Q133_splice|PDE8B_uc003kfe.2_Splice_Site_p.Q133_splice	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1						cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CCTATTCAGGTACGCCTCCTT	0.348000													28	192					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79029872	79029872	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:79029872A>T	uc003kgc.2	+	2	5356	c.5284A>T	c.(5284-5286)AAA>TAA	p.K1762*		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1762						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGCCGACTTTAAAAAGGGAGG	0.413000													16	95					0	0	0	0
RASGRF2	5924	broad.mit.edu	37	5	80363998	80363998	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:80363998G>A	uc003kha.1	+	3	543	c.543G>A	c.(541-543)GAG>GAA	p.E181E	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_5'Flank	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	181	Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTAAATCAGAGGTATTTCCCA	0.393000													11	103					0	0	0	0
PCSK1	5122	broad.mit.edu	37	5	95764933	95764933	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:95764933A>G	uc003kls.1	-	2	475	c.269T>C	c.(268-270)TTA>TCA	p.L90S		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	90					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCATCAGATAATCTCTTAGT	0.333000													20	144					0	0	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101794169	101794169	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:101794169G>A	uc003knn.2	-	6	1220	c.1048C>T	c.(1048-1050)CGT>TGT	p.R350C	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.R350C|SLCO6A1_uc003knq.2_Missense_Mutation_p.R288C	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	350	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGCTGTTTACGTTTCCTAGCT	0.294000													24	133					0	0	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130815438	130815438	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:130815438C>A	uc003kvn.1	-	16	2055	c.1849G>T	c.(1849-1851)GAG>TAG	p.E617*	RAPGEF6_uc003kvp.1_Nonsense_Mutation_p.E667*|RAPGEF6_uc003kvo.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc010jdi.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc010jdj.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc003kvq.2_Nonsense_Mutation_p.E334*|RAPGEF6_uc003kvr.2_Nonsense_Mutation_p.E617*|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Nonsense_Mutation_p.E617*	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	617					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AAAAGTAACTCTTTGAACACT	0.328000													20	112					1.01871e-10	1.15485e-10	1	0
KIF3A	11127	broad.mit.edu	37	5	132069961	132069961	+	Missense_Mutation	SNP	T	A	A	rs146249719	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:132069961T>A	uc003kxo.2	-	2	370	c.216A>T	c.(214-216)AAA>AAT	p.K72N	KIF3A_uc003kxn.2_Missense_Mutation_p.K31N|KIF3A_uc011cxf.1_Missense_Mutation_p.K72N|KIF3A_uc003kxp.2_Missense_Mutation_p.K72N	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	72	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATCAAGTTGTTTACTCTCTG	0.318000													75	142					0	0	0	0
BRD8	10902	broad.mit.edu	37	5	137496708	137496708	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:137496708G>A	uc003lcf.1	-	18	2354	c.2299C>T	c.(2299-2301)CGA>TGA	p.R767*	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Nonsense_Mutation_p.R546*|BRD8_uc003lcg.2_Nonsense_Mutation_p.R840*|BRD8_uc003lci.2_Nonsense_Mutation_p.R770*|BRD8_uc003lch.2_Nonsense_Mutation_p.R661*|BRD8_uc011cym.1_Nonsense_Mutation_p.R751*|BRD8_uc010jer.1_Nonsense_Mutation_p.R736*|BRD8_uc011cyn.1_Nonsense_Mutation_p.R726*	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	767	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTGTGCTTCGGATCAGTCCA	0.408000													15	106					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182431	140182431	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140182431C>T	uc003lhf.2	+	1	1649	c.1649C>T	c.(1648-1650)ACG>ATG	p.T550M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.T550M	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	550	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAACGTGACGCTGCAGGTG	0.687000													26	108					0	0	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250500	140250500	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140250500G>T	uc003lia.2	+	1	2670	c.1812G>T	c.(1810-1812)GCG>GCT	p.A604A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.A604A	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	604	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACAACGCGTGGCTTTCAT	0.672000													13	67					2.62699e-14	3.06274e-14	1	0
PCDHB5	26167	broad.mit.edu	37	5	140516465	140516465	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140516465C>T	uc003liq.2	+	1	1666	c.1449C>T	c.(1447-1449)GCC>GCT	p.A483A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	483	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCAACGCCCAGGTCACCT	0.637000													49	119					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718644	140718644	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140718644C>T	uc003ljk.1	+	1	291	c.106C>T	c.(106-108)CGG>TGG	p.R36W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.R36W	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	36	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCTGTGCGGGAAGAGAT	0.602000											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	95					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811076	140811076	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140811076C>A	uc003lkt.1	+	1	919	c.750C>A	c.(748-750)AGC>AGA	p.S250R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.S250R	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	250	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCGCGAGCGTTCCGGAGA	0.627000													31	68					2.70662e-09	3.0128e-09	1	0
FGF1	2246	broad.mit.edu	37	5	141974899	141974899	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:141974899G>A	uc003lmm.2	-	4	504	c.424C>T	c.(424-426)CAG>TAG	p.Q142*	FGF1_uc011dbi.1_3'UTR|FGF1_uc003lmn.3_Nonsense_Mutation_p.Q142*|FGF1_uc003lmp.3_3'UTR|FGF1_uc003lmq.2_Nonsense_Mutation_p.Q142*|FGF1_uc010jgj.2_Nonsense_Mutation_p.Q141*|FGF1_uc003lmr.2_Nonsense_Mutation_p.Q142*|FGF1_uc003lms.3_Nonsense_Mutation_p.Q142*	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	142	Heparin-binding.				angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	ATTGCTTTCTGGCCATAGTGA	0.483000													9	64					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150925209	150925209	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:150925209C>A	uc003lue.3	-	9	5492	c.5479G>T	c.(5479-5481)GAG>TAG	p.E1827*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1827	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAATCCATCTCTGATACAATG	0.433000													39	66					1.90571e-15	2.26475e-15	1	0
FAT2	2196	broad.mit.edu	37	5	150934053	150934053	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:150934053T>C	uc003lue.3	-	4	3828	c.3815A>G	c.(3814-3816)GAT>GGT	p.D1272G	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1272	Extracellular (Potential).|Cadherin 11.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGACCCTCATCCAGGTCTGA	0.557000													39	187					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176666861	176666861	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:176666861A>T	uc003mfr.3	+	8	4435	c.4297A>T	c.(4297-4299)AAA>TAA	p.K1433*	NSD1_uc003mft.3_Nonsense_Mutation_p.K1164*|NSD1_uc003mfs.1_Nonsense_Mutation_p.K1330*|NSD1_uc011dfx.1_Nonsense_Mutation_p.K1081*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1433					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGGCCTTTCTAAAAAGGTATG	0.313000			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			36	46					0	0	0	0
GRM6	2916	broad.mit.edu	37	5	178410115	178410115	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:178410115G>A	uc003mjr.2	-	9	2411	c.2232C>T	c.(2230-2232)TGC>TGT	p.C744C	GRM6_uc003mjq.2_Silent_p.C147C	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	744	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCGACATGTCGCACTTGAGCA	0.637000													7	71					0	0	0	0
FLT4	2324	broad.mit.edu	37	5	180048550	180048550	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:180048550G>A	uc003mma.3	-	13	2091	c.2012C>T	c.(2011-2013)TCG>TTG	p.S671L	FLT4_uc003mlz.3_Missense_Mutation_p.S671L|FLT4_uc003mmb.1_Missense_Mutation_p.S204L|FLT4_uc011dgy.1_Missense_Mutation_p.S671L	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	671	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACCCTGCACCGACAGGTACTT	0.677000									Congenital_Hereditary_Lymphedema				11	60					0	0	0	0
BTNL3	10917	broad.mit.edu	37	5	180432345	180432345	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:180432345C>A	uc003mmr.2	+	8	1002	c.874C>A	c.(874-876)CTG>ATG	p.L292M	BTNL3_uc010jlp.2_Missense_Mutation_p.L77M	NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	292	B30.2/SPRY.|Cytoplasmic (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGAGGTGACTCTGGATCCAGA	0.552000													19	139					1.06647e-15	1.27047e-15	1	0
DSP	1832	broad.mit.edu	37	6	7569464	7569464	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:7569464G>T	uc003mxp.1	+	12	1744	c.1465G>T	c.(1465-1467)GAG>TAG	p.E489*	DSP_uc003mxq.1_Nonsense_Mutation_p.E489*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	489	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGACAACAACGAGCGCAGCAA	0.527000													83	91					1.13027e-35	1.47505e-35	1	0
HIVEP1	3096	broad.mit.edu	37	6	12125336	12125336	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:12125336G>A	uc003nac.2	+	4	5487	c.5308G>A	c.(5308-5310)GGA>AGA	p.G1770R	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1770					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGATGAAAATGGAGCTGTTTG	0.423000													129	130					0	0	0	0
PRL	5617	broad.mit.edu	37	6	22287700	22287700	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:22287700C>A	uc003ndp.2	-	5	1134	c.615G>T	c.(613-615)AGG>AGT	p.R205S	PRL_uc003ndo.2_Missense_Mutation_p.R206S|PRL_uc003ndq.2_Missense_Mutation_p.R205S	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	205					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					TATGTGAATCCCTGCGTAGGC	0.463000													164	149					1.03592e-72	1.38499e-72	1	0
HIST1H4B	8366	broad.mit.edu	37	6	26027337	26027337	+	Silent	SNP	G	A	A	rs141516292		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:26027337G>A	uc003nfr.2	-	1	144	c.144C>T	c.(142-144)TCC>TCT	p.S48S		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	48					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						AAATCAAACCGGAAATTCGCT	0.567000													25	137					0	0	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240930	26240930	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:26240930C>T	uc003nhe.1	+	1	277	c.277C>T	c.(277-279)CGC>TGC	p.R93C		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	93					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CGCGCTCAAGCGCCAGGGACG	0.547000													7	131					0	0	0	0
OR2W1	26692	broad.mit.edu	37	6	29012622	29012622	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29012622C>G	uc003nlw.2	-	1	331	c.331G>C	c.(331-333)GAG>CAG	p.E111Q		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGAAGGCACTCAACTGAGCCC	0.433000													21	123					0	0	0	0
OR2J2	26707	broad.mit.edu	37	6	29141990	29141990	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29141990C>A	uc011dlm.1	+	1	680	c.578C>A	c.(577-579)ACC>AAC	p.T193N		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTGTTGACACCCATGCAAAT	0.473000													41	339					1.49673e-21	1.86902e-21	1	0
MOG	4340	broad.mit.edu	37	6	29638476	29638476	+	Splice_Site	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29638476A>G	uc003nnf.2	+	7	888	c.710_splice	c.e7-2	p.G237_splice	MOG_uc003nmy.1_Splice_Site_p.G237_splice|MOG_uc003nmz.2_Splice_Site|MOG_uc011dlt.1_Splice_Site_p.G167_splice|MOG_uc003nna.2_Splice_Site_p.G121_splice|MOG_uc011dlu.1_Splice_Site_p.G98_splice|MOG_uc011dlv.1_Splice_Site_p.G82_splice|MOG_uc003nnd.2_Splice_Site|MOG_uc003nne.2_Splice_Site_p.G237_splice|MOG_uc003nng.2_Splice_Site_p.G214_splice|MOG_uc003nnh.2_Splice_Site_p.G198_splice|MOG_uc003nni.2_Splice_Site_p.G214_splice|MOG_uc003nnj.2_Splice_Site_p.G198_splice|MOG_uc003nnk.2_Intron	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform						cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						TTTTGTTTTCAGGGCAATTCC	0.438000													24	30					0	0	0	0
HLA-H	3136	broad.mit.edu	37	6	29856547	29856547	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29856547G>T	uc010jro.2	+	3	594	c.542G>T	c.(541-543)GGA>GTA	p.G181V	HLA-G_uc011dmb.1_Intron|HLA-H_uc003nod.2_Intron					SubName: Full=cDNA FLJ52667, highly similar to HLA class I histocompatibility antigen, alpha chain H;												0						GCGCCTCCCGGATCGCCTGTA	0.612000													7	61					8.12818e-05	8.60014e-05	1	0
TRIM26	7726	broad.mit.edu	37	6	30166209	30166209	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:30166209C>T	uc003npr.2	-	4	740	c.531G>A	c.(529-531)GCG>GCA	p.A177A	TRIM26_uc003nps.2_Silent_p.A177A|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Silent_p.A177A	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	177							DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CACTTACCAGCGCGGCCAGGA	0.577000													17	202					0	0	0	0
NOTCH4	4855	broad.mit.edu	37	6	32180994	32180994	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:32180994G>A	uc003obb.2	-	15	2495	c.2356C>T	c.(2356-2358)CCT>TCT	p.P786S	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	786	EGF-like 20.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AAGGTGCCAGGCCTGTTCACA	0.627000													72	79					0	0	0	0
RPL10A	4736	broad.mit.edu	37	6	35438521	35438521	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:35438521A>G	uc003okp.1	+	6	682	c.648A>G	c.(646-648)CTA>CTG	p.L216L	RPL10A_uc003okq.1_Silent_p.L132L|RPL10A_uc003okr.1_Silent_p.L132L|RPL10A_uc003oks.1_Silent_p.L132L	NM_007104	NP_009035	P62906	RL10A_HUMAN	ribosomal protein L10a	216					anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			ovary(1)	1						CCCAGCGCCTATATTAAGGCA	0.493000													64	66					0	0	0	0
DAAM2	23500	broad.mit.edu	37	6	39838206	39838206	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:39838206G>T	uc003oow.2	+	8	1120	c.964G>T	c.(964-966)GCC>TCC	p.A322S	DAAM2_uc010jxc.2_Missense_Mutation_p.A322S|DAAM2_uc003oox.2_Missense_Mutation_p.A322S	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	322	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACATGAAAATGCCATCCTGGA	0.517000													7	10					2.0095e-06	2.1634e-06	1	0
DAAM2	23500	broad.mit.edu	37	6	39855276	39855276	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:39855276C>T	uc003oow.2	+	16	2124	c.1968C>T	c.(1966-1968)TCC>TCT	p.S656S	DAAM2_uc003oox.2_Silent_p.S656S|uc003ooz.1_5'Flank	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	656	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGCTGGGCTCCACTGAAGACA	0.542000													10	50					0	0	0	0
SUPT3H	8464	broad.mit.edu	37	6	44922282	44922282	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:44922282C>T	uc003oxo.2	-	10	994	c.676G>A	c.(676-678)GTT>ATT	p.V226I	SUPT3H_uc003oxn.1_Missense_Mutation_p.V215I|SUPT3H_uc011dvv.1_Missense_Mutation_p.V63I|SUPT3H_uc003oxp.2_Missense_Mutation_p.V215I|SUPT3H_uc011dvw.1_Missense_Mutation_p.V129I	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	297					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						ATTGCGACAACATTGGGTTTT	0.383000													22	265					0	0	0	0
MEP1A	4224	broad.mit.edu	37	6	46761196	46761196	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:46761196G>T	uc010jzh.1	+	1	103	c.61G>T	c.(61-63)GCT>TCT	p.A21S	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.A21S|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	21					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CCACATAGCAGCTGTACCGGT	0.343000													129	389					2.10208e-94	2.81805e-94	1	0
GPR111	222611	broad.mit.edu	37	6	47650333	47650333	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:47650333A>T	uc010jzj.1	+	6	2039	c.2038A>T	c.(2038-2040)ATT>TTT	p.I680F	GPR111_uc010jzk.1_Missense_Mutation_p.I612F|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	680	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCCTTCCACATTATCTTCTC	0.483000													52	85					0	0	0	0
EYS	346007	broad.mit.edu	37	6	66204988	66204988	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:66204988C>T	uc011dxu.1	-	4	854	c.316G>A	c.(316-318)GTT>ATT	p.V106I	EYS_uc003peq.2_Missense_Mutation_p.V106I|EYS_uc003per.1_Missense_Mutation_p.V106I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	106					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GTTTCAGAAACATTCATCAAA	0.363000													38	150					0	0	0	0
AIM1	202	broad.mit.edu	37	6	106969128	106969128	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:106969128C>G	uc003prh.2	+	2	3308	c.2821C>G	c.(2821-2823)CTA>GTA	p.L941V		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	941							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		ACGAAGCAACCTACACTTGCC	0.363000													45	61					0	0	0	0
KIAA1919	91749	broad.mit.edu	37	6	111588223	111588223	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:111588223C>G	uc003puv.3	+	4	1880	c.1458C>G	c.(1456-1458)TAC>TAG	p.Y486*		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	486	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		ATAATCAATACCCATCAAATG	0.403000													29	83					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152702405	152702405	+	Silent	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:152702405C>G	uc010kiw.2	-	56	9347	c.8745G>C	c.(8743-8745)GGG>GGC	p.G2915G	SYNE1_uc003qot.3_Silent_p.G2922G|SYNE1_uc003qou.3_Silent_p.G2915G|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_5'UTR|SYNE1_uc010kjb.1_Silent_p.G2898G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2915	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGAGCTCACACCCACTGGCAG	0.547000										HNSCC(10;0.0054)			100	148					0	0	0	0
CNKSR3	154043	broad.mit.edu	37	6	154727662	154727662	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:154727662G>C	uc003qpy.2	-	13	1999	c.1494C>G	c.(1492-1494)GAC>GAG	p.D498E		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	498	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CTCGGATGTAGTCCGCACCCC	0.567000													44	94					0	0	0	0
TCP10L2	401285	broad.mit.edu	37	6	167590618	167590618	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:167590618C>T	uc010kkp.2	+	4	625	c.494C>T	c.(493-495)CCA>CTA	p.P165L		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	165											0						TTAGCTCCTCCAAAGGTGACC	0.522000													24	58					0	0	0	0
TCP10	6953	broad.mit.edu	37	6	167791447	167791447	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:167791447G>A	uc003qvv.1	-	4	625	c.413C>T	c.(412-414)CCA>CTA	p.P138L	TCP10_uc003qvu.2_Missense_Mutation_p.P138L|TCP10_uc003qvw.2_Missense_Mutation_p.P114L	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	165						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GGTCACCTTTGGAGGAGCTAA	0.522000													42	237					0	0	0	0
SUN1	23353	broad.mit.edu	37	7	893209	893209	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:893209G>T	uc011jvp.1	+	11	1296	c.1217G>T	c.(1216-1218)GGG>GTG	p.G406V	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.G323V|SUN1_uc011jvq.1_Missense_Mutation_p.G303V|SUN1_uc003sjg.2_Missense_Mutation_p.G311V|SUN1_uc011jvr.1_Missense_Mutation_p.G215V|SUN1_uc003sji.2_Missense_Mutation_p.G244V|SUN1_uc003sjk.2_Missense_Mutation_p.G45V	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	433	Perinuclear space.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGCGCTGCCGGGCCGTCAGCT	0.647000													18	58					7.41877e-09	8.20233e-09	1	0
ABCB5	340273	broad.mit.edu	37	7	20793095	20793095	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:20793095A>G	uc003suw.3	+	18	2753	c.2207A>G	c.(2206-2208)GAG>GGG	p.E736G	ABCB5_uc010kuh.2_Missense_Mutation_p.E1181G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	736	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TTGTTGGATGAGGCCACTTCA	0.398000													23	100					0	0	0	0
JAZF1	221895	broad.mit.edu	37	7	27872583	27872583	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:27872583T>C	uc003szn.2	-	5	809	c.568A>G	c.(568-570)ATA>GTA	p.I190V	JAZF1_uc003szm.2_Missense_Mutation_p.I126V	NM_175061	NP_778231	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	190	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131						TGATACTTTATGCCATTCACA	0.438000			T	SUZ12	endometrial stromal tumours								18	32					0	0	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378427	31378427	+	Silent	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:31378427G>A	uc003tch.2	-	2	809	c.456C>T	c.(454-456)ATC>ATT	p.I152I		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	152					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GTCTCTTGCCGATTCTCAGAA	0.458000													35	110					0	0	0	0
BBS9	27241	broad.mit.edu	37	7	33388738	33388738	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:33388738C>G	uc003tdn.1	+	13	1901	c.1388C>G	c.(1387-1389)CCA>CGA	p.P463R	BBS9_uc003tdo.1_Missense_Mutation_p.P463R|BBS9_uc003tdp.1_Missense_Mutation_p.P463R|BBS9_uc003tdq.1_Missense_Mutation_p.P463R|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_5'UTR|BBS9_uc003tds.1_5'Flank|BBS9_uc011kao.1_Missense_Mutation_p.P341R	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	463					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TACGTGCAACCACCATTAGAA	0.318000									Bardet-Biedl_syndrome				22	134					0	0	0	0
CDC14C	168448	broad.mit.edu	37	7	48964485	48964485	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:48964485A>C	uc010kyv.1	+	1	329	c.217A>C	c.(217-219)AAG>CAG	p.K73Q		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						ATATTGTTGCAAGATAAATAA	0.338000													16	105					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82538228	82538228	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:82538228C>A	uc003uhx.2	-	8	13691	c.13402G>T	c.(13402-13404)GTC>TTC	p.V4468F	PCLO_uc003uhv.2_Missense_Mutation_p.V4468F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4399					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTAGAGTGGACCAATCTTTCC	0.413000													35	120					4.3181e-19	5.28484e-19	1	0
SEMA3A	10371	broad.mit.edu	37	7	83610727	83610727	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:83610727C>G	uc003uhz.2	-	14	1877	c.1562G>C	c.(1561-1563)GGG>GCG	p.G521A		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	521					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACACGCTTTCCCGTAAATATC	0.483000													16	30					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86394654	86394654	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:86394654G>A	uc003uid.2	+	2	1292	c.193G>A	c.(193-195)GGG>AGG	p.G65R	GRM3_uc010lef.2_Missense_Mutation_p.G63R|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	65	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGAAGACCGAGGGATTCAACG	0.418000													40	142					0	0	0	0
DMTF1	9988	broad.mit.edu	37	7	86817562	86817562	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:86817562C>T	uc003uih.2	+	13	1682	c.1356C>T	c.(1354-1356)GCC>GCT	p.A452A	DMTF1_uc003uii.2_Silent_p.A186A|DMTF1_uc003uij.2_Silent_p.A186A|DMTF1_uc011khb.1_Silent_p.A364A|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.A452A|DMTF1_uc003uin.2_Silent_p.A186A	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	452	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					ATAATACAGCCATCTCTTCTA	0.418000													86	288					0	0	0	0
AKAP9	10142	broad.mit.edu	37	7	91631698	91631698	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:91631698G>A	uc003ulg.2	+	8	2692	c.2467G>A	c.(2467-2469)GAA>AAA	p.E823K	AKAP9_uc003ule.2_Missense_Mutation_p.E835K|AKAP9_uc003ulf.2_Missense_Mutation_p.E823K|AKAP9_uc003uli.2_Missense_Mutation_p.E448K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	835	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAGAAATAGAAATACTTAT	0.323000			T	BRAF	papillary thyroid								46	137					0	0	0	0
VGF	7425	broad.mit.edu	37	7	100806374	100806374	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:100806374C>G	uc003uxx.3	-	2	1969	c.1751G>C	c.(1750-1752)CGG>CCG	p.R584P		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	584					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					CTGCGCGCGCCGCGCCTGGGC	0.746000													7	35					0	0	0	0
FBXL13	222235	broad.mit.edu	37	7	102553619	102553619	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:102553619G>A	uc003vaq.2	-	11	1349	c.922C>T	c.(922-924)CGG>TGG	p.R308W	FBXL13_uc010liq.1_Missense_Mutation_p.R123W|FBXL13_uc010lir.1_Missense_Mutation_p.R308W|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.R308W|LRRC17_uc003vat.2_Intron|LRRC17_uc003vau.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	308	LRR 4.										0						TCTGTGAACCGTCTGCAATAA	0.438000													19	102					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103126772	103126772	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:103126772G>T	uc003vca.2	-	61	10015	c.9855C>A	c.(9853-9855)ACC>ACA	p.T3285T	RELN_uc010liz.2_Silent_p.T3285T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3285					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCTTGAATGGTCTCCCAGT	0.502000													42	136					1.23103e-26	1.56908e-26	1	0
RELN	5649	broad.mit.edu	37	7	103180756	103180756	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:103180756C>T	uc003vca.2	-	44	6978	c.6818G>A	c.(6817-6819)GGC>GAC	p.G2273D	RELN_uc010liz.2_Missense_Mutation_p.G2273D	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2273					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATGTACCTGCCCACATTGCT	0.552000													37	115					0	0	0	0
MIR592	693177	broad.mit.edu	37	7	126698186	126698186	+	RNA	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:126698186G>A	hsa-mir-592|MI0003604	-			c.53G>A			GRM8_uc003vls.2_Intron|GRM8_uc003vlr.2_Intron|GRM8_uc011kof.1_Intron|GRM8_uc003vlt.2_Intron|GRM8_uc010lkz.1_Intron|GRM8_uc003vlu.1_Intron																	0						ACGTGATGACGCTGTGCCATC	0.443000													10	38					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133749194	133749194	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:133749194C>A	uc003vrk.2	+	18	2873	c.2838C>A	c.(2836-2838)AAC>AAA	p.N946K	EXOC4_uc011kpo.1_Missense_Mutation_p.N845K|EXOC4_uc003vrl.2_Missense_Mutation_p.N556K|EXOC4_uc011kpp.1_Missense_Mutation_p.N478K|EXOC4_uc011kpq.1_Missense_Mutation_p.N234K	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	946					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				CCACCCAGAACACGAGGCTGC	0.582000													23	96					0.00047179	0.000493873	1	0
C7orf55	154791	broad.mit.edu	37	7	139030441	139030441	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:139030441G>A	uc003vuw.3	+	2	567	c.333G>A	c.(331-333)TGG>TGA	p.W111*	LUC7L2_uc011kqs.1_Intron|LUC7L2_uc011kqt.1_Intron	NM_197964	NP_932068	Q96HJ9	CG055_HUMAN	formation of mitochondrial complexes 1 homolog	111											0						GGAAGGGCTGGGAGCCATGAA	0.438000													7	56					0	0	0	0
MGAM	8972	broad.mit.edu	37	7	141754696	141754696	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:141754696C>A	uc003vwy.2	+	27	3356	c.3302C>A	c.(3301-3303)ACA>AAA	p.T1101K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1101	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGGAAGAGTACAGGCACTATA	0.488000													29	96					2.42023e-17	2.91138e-17	1	0
Unknown	0	broad.mit.edu	37	7	142510365	142510365	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:142510365G>C	uc003wbp.2	-	2	353	c.241C>G	c.(241-243)CTC>GTC	p.L81V						SubName: Full=V_segment translation product; Flags: Fragment;																		GAGGCTGAGAGATTCTGGGGC	0.567000													5	28					0	0	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880918	142880918	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:142880918T>A	uc011ksw.1	+	1	407	c.407T>A	c.(406-408)TTT>TAT	p.F136Y		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	136	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					TTCTTCTACTTTGTGAAGATT	0.388000													63	195					0	0	0	0
FAM115A	9747	broad.mit.edu	37	7	143573297	143573297	+	Silent	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:143573297T>C	uc003wdo.1	-	2	538	c.405A>G	c.(403-405)ACA>ACG	p.T135T	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Silent_p.T135T	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	135											0	Melanoma(164;0.0903)					CCAGCTTTTCTGTCATGGTTT	0.507000													62	128					0	0	0	0
NOBOX	135935	broad.mit.edu	37	7	144096938	144096938	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:144096938G>T	uc011kue.1	-	6	1066	c.1066C>A	c.(1066-1068)CGG>AGG	p.R356R		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	356	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CACTTGGCCCGGCGATTCTGG	0.537000													14	33					2.31682e-05	2.46194e-05	1	0
MLL3	58508	broad.mit.edu	37	7	151970897	151970897	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:151970897C>T	uc003wla.2	-	7	1124	c.905G>A	c.(904-906)TGT>TAT	p.C302Y		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	302					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CATCTGGGTACATTTCTCTTC	0.433000			N		medulloblastoma								8	330					0	0	0	0
SGK223	157285	broad.mit.edu	37	8	8235565	8235565	+	Silent	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:8235565G>C	uc003wsh.3	-	2	354	c.354C>G	c.(352-354)GGC>GGG	p.G118G		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	118							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGGGGAGCTTGCCAGGGGCTC	0.547000													39	145					0	0	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998511	8998511	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:8998511A>T	uc003wsn.3	-	2	816	c.651T>A	c.(649-651)AAT>AAA	p.N217K	PPP1R3B_uc003wso.3_Missense_Mutation_p.N216K	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	217	CBM21.				glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		ACGTCTGTCCATTGCACTCGT	0.507000													45	124					0	0	0	0
FDFT1	2222	broad.mit.edu	37	8	11666366	11666366	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:11666366G>A	uc003wui.2	+	2	315	c.163G>A	c.(163-165)GCA>ACA	p.A55T	FDFT1_uc003wuh.2_5'UTR|FDFT1_uc010lsa.1_Intron|FDFT1_uc011kxe.1_5'UTR|FDFT1_uc011kxf.1_Missense_Mutation_p.A55T|FDFT1_uc011kxg.1_Intron|FDFT1_uc003wuj.2_Missense_Mutation_p.A48T|FDFT1_uc010lsb.2_5'UTR|FDFT1_uc011kxh.1_5'UTR|FDFT1_uc011kxi.1_RNA|FDFT1_uc011kxj.1_5'UTR|FDFT1_uc003wuk.2_Missense_Mutation_p.A114T|FDFT1_uc011kxk.1_5'Flank	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	55					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		TCGCAGTTTCGCAGCTGTTAT	0.572000													16	20					0	0	0	0
NEFM	4741	broad.mit.edu	37	8	24771549	24771549	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:24771549G>T	uc003xed.3	+	1	276	c.243G>T	c.(241-243)TCG>TCT	p.S81S	NEFM_uc011lac.1_Silent_p.S81S|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	81	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GCCAGTCCTCGTCCCTGCTCA	0.662000													11	27					2.49675e-24	3.17416e-24	1	0
PURG	29942	broad.mit.edu	37	8	30889548	30889548	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:30889548G>A	uc003xin.2	-	1	770	c.751C>T	c.(751-753)CGA>TGA	p.R251*	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Nonsense_Mutation_p.R251*	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	251	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CCACCTCTTCGTTCTTCTATG	0.458000													43	112					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52336292	52336292	+	Splice_Site	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:52336292C>G	uc003xqu.3	-	14	1740	c.1639_splice	c.e14-1	p.E547_splice		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor						hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCACACCTTCCTAGGGAGCAA	0.368000													9	48					0	0	0	0
YTHDF3	253943	broad.mit.edu	37	8	64098988	64098988	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:64098988G>A	uc003xuy.2	+	5	735	c.419G>A	c.(418-420)GGA>GAA	p.G140E	YTHDF3_uc010lys.2_Missense_Mutation_p.G84E|YTHDF3_uc003xuz.2_Missense_Mutation_p.G84E|YTHDF3_uc003xva.2_Missense_Mutation_p.G84E|YTHDF3_uc011len.1_Missense_Mutation_p.G84E	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	140											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			GGGACAAGTGGATCTCAGGGA	0.433000													18	64					0	0	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68123821	68123821	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:68123821A>G	uc003xxo.1	-	34	5106	c.4716T>C	c.(4714-4716)ATT>ATC	p.I1572I	ARFGEF1_uc003xxl.1_Silent_p.I1026I|ARFGEF1_uc003xxn.1_Silent_p.I549I	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1572					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding	p.I1572V(1)		ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TAGAATCATGAATATCTACAG	0.323000													35	65					0	0	0	0
NECAB1	64168	broad.mit.edu	37	8	91937823	91937823	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:91937823C>T	uc011lgg.1	+	7	749	c.555C>T	c.(553-555)CGC>CGT	p.R185R		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	185					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GATCAAGCCGCCGAGTCCAGA	0.458000													13	25					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	93023240	93023240	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:93023240G>A	uc003yfd.2	-	4	632	c.548C>T	c.(547-549)CCA>CTA	p.P183L	RUNX1T1_uc003yfc.1_Missense_Mutation_p.P156L|RUNX1T1_uc003yfe.1_Missense_Mutation_p.P146L|RUNX1T1_uc010mao.2_Missense_Mutation_p.P156L|RUNX1T1_uc011lgi.1_Missense_Mutation_p.P194L|RUNX1T1_uc003yfh.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yfb.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yff.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yfg.1_Missense_Mutation_p.P146L	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	183	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CTTCAAAAATGGGATGACAAA	0.363000													40	132					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113395840	113395840	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:113395840T>C	uc003ynu.2	-	37	6146	c.5987A>G	c.(5986-5988)TAT>TGT	p.Y1996C	CSMD3_uc003yns.2_Missense_Mutation_p.Y1198C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y1956C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y1892C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1996	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCCCCATCATAAAAGTCCAG	0.333000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			42	99					0	0	0	0
HAS2	3037	broad.mit.edu	37	8	122626624	122626624	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:122626624C>T	uc003yph.2	-	4	1922	c.1384G>A	c.(1384-1386)GGG>AGG	p.G462R		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	462	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GTGCCCCACCCAGCTTTGTTT	0.413000													135	281					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	125052147	125052147	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:125052147C>T	uc003yqw.2	+	20	2695	c.2489C>T	c.(2488-2490)GCT>GTT	p.A830V	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	830	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAGCTGAGGGCTCACATGTAC	0.507000													68	106					0	0	0	0
LRRC6	23639	broad.mit.edu	37	8	133622460	133622460	+	Silent	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:133622460A>G	uc003ytk.2	-	10	1166	c.1092T>C	c.(1090-1092)TCT>TCC	p.S364S	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	364	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCTTTTAGCAGAACTACTAT	0.428000													42	186					0	0	0	0
ZNF696	79943	broad.mit.edu	37	8	144378710	144378710	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:144378710G>A	uc003yxy.3	+	3	1274	c.865G>A	c.(865-867)GGG>AGG	p.G289R		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CGTGCACACGGGGGAGCGGCC	0.726000													5	10					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	145008864	145008864	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:145008864A>T	uc003zaf.1	-	10	1561	c.1391T>A	c.(1390-1392)ATG>AAG	p.M464K	PLEC_uc003zab.1_Missense_Mutation_p.M327K|PLEC_uc003zac.1_Missense_Mutation_p.M331K|PLEC_uc003zad.2_Missense_Mutation_p.M327K|PLEC_uc003zae.1_Missense_Mutation_p.M295K|PLEC_uc003zag.1_Missense_Mutation_p.M305K|PLEC_uc003zah.2_Missense_Mutation_p.M313K|PLEC_uc003zaj.2_Missense_Mutation_p.M354K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	464	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGGTAGCTCCATCTCCTTAAA	0.637000													64	135					0	0	0	0
ZNF251	90987	broad.mit.edu	37	8	145948593	145948593	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:145948593G>A	uc003zdv.3	-	5	708	c.452C>T	c.(451-453)GCC>GTC	p.A151V		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACTCTGCCCGGCAGAATTTCC	0.483000													4	180					0	0	0	0
JAK2	3717	broad.mit.edu	37	9	5054676	5054676	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:5054676G>A	uc010mhm.2	+	6	841	c.728G>A	c.(727-729)TGC>TAC	p.C243Y	JAK2_uc003ziw.2_Missense_Mutation_p.C243Y	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	243	FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTCAGCCAATGCAAAGCCACT	0.368000		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				70	164					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763586	5763586	+	Silent	SNP	A	G	G	rs147383296		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:5763586A>G	uc003zji.2	+	18	2415	c.2322A>G	c.(2320-2322)ACA>ACG	p.T774T	KIAA1432_uc003zjh.2_Silent_p.T774T|KIAA1432_uc003zjl.3_Silent_p.T737T|KIAA1432_uc003zjj.1_Silent_p.T316T	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	853						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCTGTGCCACATTACCTTACT	0.537000													30	127					0	0	0	0
KDM4C	23081	broad.mit.edu	37	9	6805761	6805761	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:6805761G>A	uc003zkh.2	+	3	887	c.307G>A	c.(307-309)GCC>ACC	p.A103T	KDM4C_uc010mhu.2_Missense_Mutation_p.A125T|KDM4C_uc010mhw.2_Missense_Mutation_p.A103T|KDM4C_uc011lmi.1_Missense_Mutation_p.A103T|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.A103T|KDM4C_uc011lmk.1_Intron|KDM4C_uc010mhv.2_Missense_Mutation_p.A103T	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	103					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CAGGCAGCTGGCCAACAGTGG	0.418000													33	66					0	0	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889684	18889684	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:18889684C>G	uc003zne.3	+	25	4708	c.4581C>G	c.(4579-4581)TGC>TGG	p.C1527W	ADAMTSL1_uc003znf.3_Missense_Mutation_p.C228W	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1527						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CTGCCCACTGCGCAGGGAAGG	0.657000													16	23					0	0	0	0
IFNW1	3467	broad.mit.edu	37	9	21141013	21141013	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:21141013C>G	uc003zol.1	-	1	1132	c.557G>C	c.(556-558)AGA>ACA	p.R186T		NM_002177	NP_002168	P05000	IFNW1_HUMAN	interferon, omega 1 precursor	186					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATCTTTACTTCTCAGTCTTTC	0.378000													20	110					0	0	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762230	23762230	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:23762230C>A	uc003zpu.2	-	2	278	c.3G>T	c.(1-3)ATG>ATT	p.M1I	ELAVL2_uc003zps.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpt.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpv.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpw.2_Missense_Mutation_p.M1I	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	1					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		GTTGTGTTTCCATGGCAGCAA	0.403000													121	301					3.28517e-43	4.33326e-43	1	0
LINGO2	158038	broad.mit.edu	37	9	27949987	27949987	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:27949987T>A	uc003zqu.1	-	2	877	c.683A>T	c.(682-684)AAA>ATA	p.K228I	LINGO2_uc010mjf.1_Missense_Mutation_p.K228I|LINGO2_uc003zqv.1_Missense_Mutation_p.K228I	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	228	LRR 8.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CTCTAGGTGTTTCAGGTGGAA	0.473000													27	119					0	0	0	0
Unknown	0	broad.mit.edu	37	9	90747193	90747193	+	Silent	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:90747193C>A	uc011lti.1	-	4	788	c.759G>T	c.(757-759)CTG>CTT	p.L253L						SubName: Full=cDNA FLJ59639;																		GGACGGTGTCCAGTGGAAGTG	0.582000													70	118					2.00703e-41	2.64026e-41	1	0
ROR2	4920	broad.mit.edu	37	9	94487036	94487036	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:94487036G>T	uc004arj.1	-	9	1939	c.1740C>A	c.(1738-1740)GAC>GAA	p.D580E	ROR2_uc004ari.1_Missense_Mutation_p.D440E	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	580	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.D580Y(1)		lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TCACCGTGCGGTCATCATCGG	0.632000													6	51					2.7689e-08	3.04764e-08	1	0
OR13C8	138802	broad.mit.edu	37	9	107332082	107332082	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:107332082T>G	uc011lvo.1	+	1	634	c.634T>G	c.(634-636)TTA>GTA	p.L212V		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TATTCCATTGTTAGTAATTTC	0.403000													53	139					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898525	112898525	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:112898525T>C	uc004bei.2	+	9	1589	c.1397T>C	c.(1396-1398)ATT>ACT	p.I466T	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.I234T|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.I234T|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.I44T|AKAP2_uc011lwi.1_Missense_Mutation_p.I92T|AKAP2_uc004bem.2_Missense_Mutation_p.I92T|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.I52T|AKAP2_uc011lwj.1_Missense_Mutation_p.I3T|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.I3T	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	3							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AACATGGAAATTGAGGTGTCT	0.502000													45	222					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117848972	117848972	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:117848972G>T	uc004bjj.3	-	3	1400	c.1038C>A	c.(1036-1038)TGC>TGA	p.C346*	TNC_uc010mvf.2_Nonsense_Mutation_p.C346*	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	346	EGF-like 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						AGGCATGTGGGCAGGTGGGTT	0.612000													12	60					1.5842e-08	1.74759e-08	1	0
OR5C1	392391	broad.mit.edu	37	9	125551651	125551651	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:125551651C>T	uc011lzd.1	+	1	440	c.440C>T	c.(439-441)GCC>GTC	p.A147V		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						CTATGCCTGGCCTTGCTGGGA	0.572000													40	74					0	0	0	0
LHX2	9355	broad.mit.edu	37	9	126776323	126776323	+	Silent	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:126776323G>T	uc004boe.1	+	2	943	c.204G>T	c.(202-204)GCG>GCT	p.A68A	LHX2_uc010mwi.1_Silent_p.A68A	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	68	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACCTGCTGGCGGTGGACAAGC	0.637000													18	94					3.51602e-12	4.07031e-12	1	0
PRDM12	59335	broad.mit.edu	37	9	133542106	133542106	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:133542106C>A	uc004bzt.1	+	2	395	c.335C>A	c.(334-336)ACC>AAC	p.T112N		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	112	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		AAGGCGGGAACCGAGATGGGC	0.647000													36	125					6.07928e-31	7.82985e-31	1	0
MAMDC4	158056	broad.mit.edu	37	9	139748462	139748462	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:139748462C>T	uc004cjs.2	+	6	654	c.604C>T	c.(604-606)CGA>TGA	p.R202*	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	202	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTCTGCCACCCGAAATGCCAC	0.622000													25	122					0	0	0	0
CDKL5	6792	broad.mit.edu	37	X	18602398	18602398	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:18602398T>G	uc004cym.2	+	8	732	c.479T>G	c.(478-480)CTG>CGG	p.L160R	CDKL5_uc004cyn.2_Missense_Mutation_p.L160R	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	160	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GCTCGTAATCTGTCAGAAGGC	0.383000													30	116					0	0	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998655	27998655	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:27998655C>T	uc004dbx.1	-	1	912	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	266	WD 2.									ovary(3)|skin(1)	4						TTCTGCTACCCGTACCTGTCC	0.493000													27	40					0	0	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260456	30260456	+	Silent	SNP	C	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:30260456C>G	uc004dcb.2	+	1	288	c.204C>G	c.(202-204)ACC>ACG	p.T68T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	68										ovary(1)	1						AGCCACCCACCACCTCTGCTG	0.532000													15	13					0	0	0	0
CACNA1F	778	broad.mit.edu	37	X	49075889	49075889	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:49075889G>T	uc004dnb.2	-	21	2659	c.2597C>A	c.(2596-2598)ACC>AAC	p.T866N	CACNA1F_uc010nip.2_Missense_Mutation_p.T855N	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	866	III.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GTGGATGAGGGTGTGGCAGCC	0.567000													5	7					0.00198382	0.0020462	1	0
GSPT2	23708	broad.mit.edu	37	X	51488052	51488052	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:51488052A>C	uc004dpl.2	+	1	1556	c.1330A>C	c.(1330-1332)ACT>CCT	p.T444P		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	444					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					AGATATGGGCACTGTGGTCCT	0.413000													33	30					0	0	0	0
SSX8	280659	broad.mit.edu	37	X	52654089	52654089	+	RNA	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:52654089T>C	uc011moa.1	+	2		c.326T>C			SSX8_uc011mob.1_RNA					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0						CCAGGGATGATGATAAAGCAT	0.557000													26	77					0	0	0	0
FOXO4	4303	broad.mit.edu	37	X	70321491	70321491	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:70321491G>C	uc004dys.1	+	2	1764	c.1411G>C	c.(1411-1413)GAT>CAT	p.D471H	FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Missense_Mutation_p.D416H	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	471					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					TCAGGATCTAGATCTTGATAT	0.527000													46	42					0	0	0	0
TBX22	50945	broad.mit.edu	37	X	79282239	79282239	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:79282239G>T	uc010nmg.1	+	6	804	c.670G>T	c.(670-672)GTG>TTG	p.V224L	TBX22_uc004edi.1_Missense_Mutation_p.V104L|TBX22_uc004edj.1_Missense_Mutation_p.V224L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	224	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CAAACCCCGAGTGCACGTGAT	0.453000													37	44					1.30998e-17	1.58747e-17	1	0
LOC442459	442459	broad.mit.edu	37	X	98974724	98974724	+	RNA	SNP	G	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:98974724G>T	uc011mrd.1	-	8		c.1619C>A				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						GCTGCAGCACGGGGTTCTCAA	0.458000													18	19					1.28384e-07	1.40679e-07	1	0
NXF4	55999	broad.mit.edu	37	X	101818928	101818928	+	RNA	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:101818928G>A	uc004ejf.1	+	9		c.1212G>A				NR_002216				Homo sapiens cDNA FLJ42710 fis, clone BRAMY3007609, moderately similar to Homo sapiens nuclear RNA export factor 2 (NXF2).												0						ATGGCTGGAAGGGAACTCATT	0.557000													22	12					0	0	0	0
NXF3	56000	broad.mit.edu	37	X	102332615	102332615	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:102332615C>T	uc004eju.2	-	18	1582	c.1511G>A	c.(1510-1512)AGT>AAT	p.S504N	NXF3_uc010noi.1_3'UTR	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	504						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GAACAAGGCACTCTGGGTCCC	0.567000													63	32					0	0	0	0
PAK3	5063	broad.mit.edu	37	X	110385414	110385414	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:110385414G>C	uc004epa.2	+	2	293	c.266G>C	c.(265-267)GGG>GCG	p.G89A	PAK3_uc010npt.1_Missense_Mutation_p.G89A|PAK3_uc010npu.1_Missense_Mutation_p.G89A|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.G89A|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.G89A|PAK3_uc010npw.1_Missense_Mutation_p.G89A	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	89	Autoregulatory region (By similarity).|Linker.|GTPase-binding (By similarity).				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GCAGTCACCGGGGAATTCACT	0.418000										TSP Lung(19;0.15)			82	80					0	0	0	0
BCORL1	63035	broad.mit.edu	37	X	129171509	129171509	+	Splice_Site	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:129171509G>A	uc004evb.1	+	9	4586	c.4472_splice	c.e9+1	p.R1491_splice	BCORL1_uc004evc.1_Splice_Site_p.R327_splice	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACGGCACGAGGCAAGAGGGCT	0.582000													49	46					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994507	140994507	+	Silent	SNP	C	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:140994507C>T	uc004fbt.2	+	4	1603	c.1317C>T	c.(1315-1317)CCC>CCT	p.P439P	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	439							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGTTTTCCCCAGTCTCCTC	0.453000										HNSCC(15;0.026)			108	106					0	0	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717807	142717807	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:142717807A>G	uc004fbx.2	-	2	1494	c.1118T>C	c.(1117-1119)ATA>ACA	p.I373T	SLITRK4_uc004fby.2_Missense_Mutation_p.I373T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	373	Extracellular (Potential).|LRRNT.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTTTCGGTATCAGTTCAGA	0.443000													103	76					0	0	0	0
AFF2	2334	broad.mit.edu	37	X	148037158	148037158	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:148037158G>A	uc004fcp.2	+	11	2062	c.1583G>A	c.(1582-1584)TGG>TAG	p.W528*	AFF2_uc004fcq.2_Nonsense_Mutation_p.W518*|AFF2_uc004fcr.2_Nonsense_Mutation_p.W489*|AFF2_uc011mxb.1_Nonsense_Mutation_p.W493*|AFF2_uc004fcs.2_Nonsense_Mutation_p.W495*|AFF2_uc011mxc.1_Nonsense_Mutation_p.W169*	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	528					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAACAAGTGGCAACTGGAT	0.443000													115	107					0	0	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900745	151900745	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:151900745T>C	uc010ntp.2	-	3	410	c.56A>G	c.(55-57)CAA>CGA	p.Q19R	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.Q19R|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	19										skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTCTCCTTGGGCCTCAAG	0.617000													19	50					0	0	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16953106	16953106	+	Silent	SNP	A	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrY:16953106A>T	uc004ftg.2	+	6	2667	c.2415A>T	c.(2413-2415)ACA>ACT	p.T805T	NLGN4Y_uc004fte.2_Silent_p.T637T|NLGN4Y_uc011nas.1_Silent_p.T825T|NLGN4Y_uc004ftf.2_Silent_p.T498T|NLGN4Y_uc004fth.2_Silent_p.T805T	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	805	Cytoplasmic (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						AAAACAGTACAAATTTACCCC	0.433000													23	17					0	0	0	0
Unknown	0	broad.mit.edu	37	1	34789507	34789508	+	IGR	INS	-	T	T	rs71029034		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:34789507_34789508insT								C1orf94 (104778 upstream) : MIR552 (345692 downstream)																							tccttccttcctccttccttcc	0.025													---	---	---							
SELE	6401	broad.mit.edu	37	1	169698381	169698381	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:169698381delG	uc001ggm.3	-	7	1193	c.1036delC	c.(1036-1038)CAGfs	p.Q346fs	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	346	Extracellular (Potential).|Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					CATTCAACCTGGGCTGGTCCC	0.488													---	---	---							
BAT2L2	23215	broad.mit.edu	37	1	171452363	171452363	+	5'Flank	DEL	A	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:171452363delA	uc010pmg.1	+						BAT2L2_uc001ghq.1_5'Flank|BAT2L2_uc001ghr.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2								protein C-terminus binding				0						ctccatggggaaaaaaaaaaa	0.000													---	---	---							
SMG7	9887	broad.mit.edu	37	1	183515266	183515267	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:183515266_183515267insA	uc001gqg.2	+	17	2658_2659	c.2536_2537insA	c.(2536-2538)GAAfs	p.E846fs	SMG7_uc010pob.1_Frame_Shift_Ins_p.E829fs|SMG7_uc001gqf.2_Frame_Shift_Ins_p.E800fs|SMG7_uc001gqh.2_Frame_Shift_Ins_p.E800fs|SMG7_uc001gqi.2_Frame_Shift_Ins_p.E758fs|SMG7_uc010poc.1_Frame_Shift_Ins_p.E804fs	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	846					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GCAGCCTCTAGAAAAAAAAATG	0.450													---	---	---							
OR14A16	284532	broad.mit.edu	37	1	247978121	247978121	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:247978121delC	uc001idm.1	-	1	911	c.911delG	c.(910-912)GGAfs	p.G304fs		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTGAGCTTTCCCTTTATCAA	0.343													---	---	---							
ITIH5	80760	broad.mit.edu	37	10	7708782	7708782	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:7708782delC	uc001ijq.2	-	1	153	c.74delG	c.(73-75)GGCfs	p.G25fs	ITIH5_uc001ijr.1_Frame_Shift_Del_p.G25fs	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	25					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CGAAGAGTGGCCCCAGCTCTG	0.567													---	---	---							
Unknown	0	broad.mit.edu	37	10	27620447	27620448	+	IGR	INS	-	TT	TT	rs142562667	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:27620447_27620448insTT								LOC387646 (79212 upstream) : PTCHD3 (66669 downstream)																							ACTCAGGCTTCTTTCCGCCAAG	0.465													---	---	---							
Unknown	0	broad.mit.edu	37	10	31435693	31435694	+	IGR	DEL	CG	-	-	rs146437327		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:31435693_31435694delCG								ZNF438 (114827 upstream) : LOC220930 (169764 downstream)																							CGTacacacacgcacacacaca	0.431													---	---	---							
Unknown	0	broad.mit.edu	37	10	81632947	81632948	+	IGR	INS	-	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:81632947_81632948insT								LOC650623 (184299 upstream) : MBL1P (31706 downstream)																							CTCTTCAtttcttttttttttt	0.218													---	---	---							
HTR7	3363	broad.mit.edu	37	10	92617175	92617175	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:92617175delC	uc001kha.2	-	1	497	c.254delG	c.(253-255)GGCfs	p.G85fs	HTR7_uc001kgz.2_Frame_Shift_Del_p.G85fs|HTR7_uc001khb.2_Frame_Shift_Del_p.G85fs	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	85	Helical; Name=1; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CAGGATGGAGCCGATCACAAC	0.632													---	---	---							
Unknown	0	broad.mit.edu	37	10	99068840	99068840	+	IGR	DEL	T	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:99068840delT								ARHGAP19 (16427 upstream) : FRAT1 (10182 downstream)																							AAAAAGTTTGTTTTTTTTTTT	0.174													---	---	---							
OR4C6	219432	broad.mit.edu	37	11	55433099	55433100	+	Frame_Shift_Ins	INS	-	A	A	rs149652704		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:55433099_55433100insA	uc001nht.3	+	3	722_723	c.457_458insA	c.(457-459)CACfs	p.H153fs	OR4C6_uc010rik.1_Frame_Shift_Ins_p.H153fs	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GGGATTTATGCACGCAATGATA	0.470													---	---	---							
Unknown	0	broad.mit.edu	37	11	56098812	56098813	+	IGR	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:56098812_56098813insG								OR8K3 (12093 upstream) : OR8K1 (14702 downstream)																							ATCAGGGCTTTGGGGGCATCAT	0.411													---	---	---							
Unknown	0	broad.mit.edu	37	11	70113693	70113696	+	IGR	DEL	AGGA	-	-	rs71974523		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:70113693_70113696delAGGA								FADD (60185 upstream) : PPFIA1 (3127 downstream)																							gaaggaagggaggaaggaaggaag	0.118													---	---	---							
SLCO2B1	11309	broad.mit.edu	37	11	74873807	74873807	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:74873807delC	uc001owb.2	+	2	511	c.124delC	c.(124-126)CCAfs	p.P42fs	SLCO2B1_uc010rrp.1_RNA|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Frame_Shift_Del_p.P20fs	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	42	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	GGACGTGCGGCCAAGTGTGTT	0.483													---	---	---							
Unknown	0	broad.mit.edu	37	11	130308386	130308387	+	IGR	DEL	CC	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:130308386_130308387delCC								ADAMTS8 (9847 upstream) : ADAMTS15 (10482 downstream)																							ttccttccttccttccttcctt	0.094													---	---	---							
Unknown	0	broad.mit.edu	37	12	125396165	125396166	+	IGR	INS	-	AAAAAAAAA	AAAAAAAAA	rs68000265		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:125396165_125396166insAAAAAAAAA								SCARB1 (47646 upstream) : UBC (28 downstream)																							AAAATAAACTTaaaaaaaaaaa	0.361													---	---	---							
ADAM6	8755	broad.mit.edu	37	14	106208061	106208061	+	RNA	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:106208061delG	uc010tyt.1	-	3628		c.59056delC			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Frame_Shift_Del_p.L114fs|uc001ysf.2_Frame_Shift_Del_p.L114fs					Parts of antibodies, mostly variable regions.												0						AGGCAGGTCAGGCTGACCTGG	0.617													---	---	---							
Unknown	0	broad.mit.edu	37	16	13891855	13891862	+	IGR	DEL	AGGAAGGC	-	-	rs4581719	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:13891855_13891862delAGGAAGGC								SHISA9 (557583 upstream) : ERCC4 (122152 downstream)																							gagagaaggaaggaaggcaggaaggaag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	16	31985183	31985183	+	IGR	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:31985183delG								ZNF267 (56557 upstream) : HERC2P4 (177427 downstream)																							CTCCAGGGAAGGGGCTGGAGT	0.507													---	---	---							
Unknown	0	broad.mit.edu	37	18	47823607	47823607	+	IGR	DEL	A	-	-	rs143466162	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:47823607delA								CXXC1 (8915 upstream) : SKA1 (77785 downstream)																							agaaggaaggaaaggaaggaa	0.000													---	---	---							
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	-	-	rs62639328	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:46299165_46299167delCCT	uc002pdm.2	-	6	2257_2259	c.2114_2116delAGG	c.(2113-2118)GAGGGC>GGC	p.E705del	RSPH6A_uc002pdl.2_In_Frame_Del_p.E441del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	705	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						tcctcctcgccctcctcctcctc	0.438													---	---	---							
SH3RF3	344558	broad.mit.edu	37	2	110036087	110036088	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:110036087_110036088insT	uc010ywt.1	+	5	1392_1393	c.1392_1393insT	c.(1390-1395)CTGCCCfs	p.L464fs		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	464_465	SH3 3.						zinc ion binding			ovary(1)	1						AGGTCCAGCTGCCCCTCAACGT	0.663													---	---	---							
IL1B	3553	broad.mit.edu	37	2	113596301	113596312	+	5'Flank	DEL	TTTCTTTCTTTC	-	-	rs10560590		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:113596301_113596312delTTTCTTTCTTTC	uc002tii.1	-							NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein						activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	tttcttttcttttctttctttctttctttctt	0.099													---	---	---							
EPHA4	2043	broad.mit.edu	37	2	222307601	222307602	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:222307601_222307602insA	uc002vmq.2	-	11	2063_2064	c.2021_2022insT	c.(2020-2022)ATGfs	p.M674fs	EPHA4_uc002vmr.2_Frame_Shift_Ins_p.M674fs|EPHA4_uc010zlm.1_Frame_Shift_Ins_p.M615fs|EPHA4_uc010zln.1_Frame_Shift_Ins_p.M674fs	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	674	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CAAACTGTCCCATGATGCTGGC	0.480													---	---	---							
Unknown	0	broad.mit.edu	37	21	20230561	20230561	+	IGR	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:20230561delG								TMPRSS15 (454591 upstream) : None (None downstream)																							CCAGCAAGAAGATCACCATTG	0.483													---	---	---							
Unknown	0	broad.mit.edu	37	21	24474163	24474163	+	IGR	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:24474163delC								None (None upstream) : None (None downstream)																							TCAGGAATCACAAAGAGAAAA	0.279													---	---	---							
Unknown	0	broad.mit.edu	37	21	40499407	40499408	+	IGR	INS	-	G	G	rs145268564	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:40499407_40499408insG								ETS2 (302531 upstream) : PSMG1 (47982 downstream)																							TTCATTGTtttttttttgtttt	0.312													---	---	---							
ZNRF3	84133	broad.mit.edu	37	22	29446545	29446546	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:29446545_29446546insG	uc003aeg.2	+	8	2241_2242	c.2076_2077insG	c.(2074-2079)GGAGGGfs	p.G692fs	ZNRF3_uc003aeh.1_Frame_Shift_Ins_p.G692fs	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	792_793	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						GCGGGGGCGGAGGGGGCAGCGG	0.658													---	---	---							
Unknown	0	broad.mit.edu	37	3	83790732	83790733	+	IGR	INS	-	GGAG	GGAG	rs13089076		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:83790732_83790733insGGAG								None (None upstream) : None (None downstream)																							aaggaaggaaaggagggaggga	0.089													---	---	---							
KIAA1257	57501	broad.mit.edu	37	3	128711936	128711937	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:128711936_128711937insG	uc003elj.3	-	2	407_408	c.211_212insC	c.(211-213)CACfs	p.H71fs	KIAA1257_uc003elg.1_Frame_Shift_Ins_p.H71fs|KIAA1257_uc003eli.3_5'Flank	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	71											0						GGGGACCACGTGGGGCACGTCG	0.574													---	---	---							
Unknown	0	broad.mit.edu	37	3	128937733	128937736	+	IGR	DEL	CTTC	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:128937733_128937736delCTTC								CNBP (34923 upstream) : COPG (30717 downstream)																							cattctttctcttccttccttcct	0.235													---	---	---							
ATP13A5	344905	broad.mit.edu	37	3	193007781	193007782	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:193007781_193007782insG	uc011bsq.1	-	26	2915_2916	c.2915_2916insC	c.(2914-2916)CCTfs	p.P972fs		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	972					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AAAGCAGTAAAGGGGGAGAAAG	0.421													---	---	---							
DGKQ	1609	broad.mit.edu	37	4	954932	954932	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:954932delG	uc003gbw.2	-	22	2706	c.2632delC	c.(2632-2634)CGAfs	p.R878fs	DGKQ_uc010ibn.2_Frame_Shift_Del_p.R865fs	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	878					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGCGTGACTCGGAAGTAGGAA	0.692													---	---	---							
Unknown	0	broad.mit.edu	37	4	46725773	46725775	+	IGR	DEL	GTT	-	-	rs80135740		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:46725773_46725775delGTT								GABRA2 (333352 upstream) : COX7B2 (11074 downstream)																							ttttttcttggtttttttttttt	0.340													---	---	---							
FAT1	2195	broad.mit.edu	37	4	187558038	187558039	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:187558038_187558039insG	uc003izf.2	-	5	3860_3861	c.3672_3673insC	c.(3670-3675)CCCAAAfs	p.P1224fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1224_1225	Extracellular (Potential).|Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGGTTGATTTGGGGGGACTAC	0.361										HNSCC(5;0.00058)			---	---	---							
SLC9A3	6550	broad.mit.edu	37	5	524328	524328	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:524328delC	uc003jbe.2	-	1	222	c.110delG	c.(109-111)GGCfs	p.G37fs	SLC9A3_uc011clx.1_Frame_Shift_Del_p.G37fs	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	37	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCCGCTCTCGCCGTGCGCGCC	0.443													---	---	---							
Unknown	0	broad.mit.edu	37	5	33090432	33090433	+	IGR	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:33090432_33090433insG								C5orf23 (298613 upstream) : TARS (350369 downstream)																							ATGAATTTCTTGAACACGTGGC	0.322													---	---	---							
Unknown	0	broad.mit.edu	37	5	33111479	33111480	+	IGR	DEL	GT	-	-	rs10544573		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:33111479_33111480delGT								C5orf23 (319660 upstream) : TARS (329322 downstream)																							attaaataaggtgtgtgtgtgt	0.198													---	---	---							
DNAJC21	134218	broad.mit.edu	37	5	34954712	34954712	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:34954712delC	uc003jjc.2	+	12	1716	c.1489delC	c.(1489-1491)CTTfs	p.L497fs	DNAJC21_uc003jjb.2_Frame_Shift_Del_p.L542fs	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	497	C2H2-type 2.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TCGGAATAAACTTTTTGACCA	0.383													---	---	---							
NQO2	4835	broad.mit.edu	37	6	2997064	2997071	+	5'Flank	DEL	CCTTCCTT	-	-	rs72450506		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:2997064_2997071delCCTTCCTT	uc003mus.2	+						NQO2_uc003mup.1_Intron|NQO2_uc003mut.2_5'Flank	NM_000904	NP_000895	P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2							cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			ovary(1)	1	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)	TGCCTGGTACccttccttccttccttcc	0.029													---	---	---							
Unknown	0	broad.mit.edu	37	6	8323263	8323264	+	IGR	INS	-	TTCCTTCT	TTCCTTCT	rs139963481	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:8323263_8323264insTTCCTTCT								EEF1E1 (220435 upstream) : SLC35B3 (88469 downstream)																							tctttctttccttccttctttc	0.000													---	---	---							
SGK223	157285	broad.mit.edu	37	8	8175731	8175732	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:8175731_8175732insC	uc003wsh.3	-	5	4153_4154	c.4153_4154insG	c.(4153-4155)GCGfs	p.A1385fs		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1385							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CTCCGCAGACGCCAGGTACTGG	0.649													---	---	---							
Unknown	0	broad.mit.edu	37	8	48076457	48076457	+	IGR	DEL	A	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:48076457delA								BEYLA (309050 upstream) : KIAA0146 (97085 downstream)																							TCCAGATTTTAAAAAAAAAAT	0.532													---	---	---							
Unknown	0	broad.mit.edu	37	8	96977958	96977958	+	IGR	DEL	G	-	-	rs35277274		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:96977958delG								C8orf37 (696521 upstream) : GDF6 (176602 downstream)																							aaggaaggaagggaaggaagg	0.119													---	---	---							
Unknown	0	broad.mit.edu	37	8	110948437	110948440	+	IGR	DEL	AGGA	-	-	rs147604132	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:110948437_110948440delAGGA								SYBU (244417 upstream) : KCNV1 (30795 downstream)																							ggagggagggaggaaggaaggaag	0.103													---	---	---							
Unknown	0	broad.mit.edu	37	9	65577178	65577178	+	IGR	DEL	G	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:65577178delG								FAM74A4 (82792 upstream) : LOC442421 (919292 downstream)																							GGAAAACTTTGtttttttttt	0.383													---	---	---							
Unknown	0	broad.mit.edu	37	9	68455229	68455230	+	IGR	INS	-	AC	AC			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:68455229_68455230insAC								FAM27B (661040 upstream) : MIR1299 (547009 downstream)																							GGGAGACTTCTGTGCAGAGGCT	0.584													---	---	---							
Unknown	0	broad.mit.edu	37	9	69634663	69634664	+	RNA	INS	-	G	G			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:69634663_69634664insG	uc004afu.3	-	3		c.407_408insC								Homo sapiens aquaporin 7 pseudogene 2, mRNA (cDNA clone IMAGE:30406582).																		GGTGAAGATGCGGGGGGGGCAG	0.569													---	---	---							
SVEP1	79987	broad.mit.edu	37	9	113168483	113168483	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:113168483delC	uc010mtz.2	-	38	9734	c.9397delG	c.(9397-9399)GCAfs	p.A3133fs	SVEP1_uc010mty.2_Frame_Shift_Del_p.A1059fs	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3133	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTCCAGTTGCCACTGCATTG	0.512													---	---	---							
