Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
EYA3	2140	broad.mit.edu	37	1	28384547	28384547	+	Translation_Start_Site	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:28384547T>C	uc001bpi.1	-	2	156	c.-9A>G	c.(-11--7)ATATT>ATGTT		EYA3_uc010ofs.1_Translation_Start_Site|EYA3_uc010oft.1_Translation_Start_Site|EYA3_uc001bpj.2_Translation_Start_Site|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3						anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TGAGGACCAATATTTCTTTAT	0.328													45	31					0	0	0	0
DOCK7	85440	broad.mit.edu	37	1	62943474	62943474	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:62943474C>A	uc001daq.2	-	43	5532	c.5498G>T	c.(5497-5499)CGT>CTT	p.R1833L	DOCK7_uc001dan.2_Missense_Mutation_p.R1696L|DOCK7_uc001dao.2_Missense_Mutation_p.R1694L|DOCK7_uc001dap.2_Missense_Mutation_p.R1813L|DOCK7_uc001dam.2_Missense_Mutation_p.R1015L|DOCK7_uc010oov.1_Missense_Mutation_p.R574L|DOCK7_uc001dar.1_Missense_Mutation_p.R7L	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1844	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AAAACCAACACGAAAATAGGT	0.363													30	44					1.71298e-08	2.06351e-08	1	0
LPAR3	23566	broad.mit.edu	37	1	85331581	85331581	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:85331581C>T	uc001dkl.2	-	1	262	c.223G>A	c.(223-225)GCC>ACC	p.A75T	LPAR3_uc009wcj.1_Missense_Mutation_p.A75T	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	75	Helical; Name=2; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AAGAAATCGGCAGCAGCTAAA	0.423													22	108					0	0	0	0
BARHL2	343472	broad.mit.edu	37	1	91180103	91180103	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:91180103C>T	uc001dns.2	-	2	878	c.836G>A	c.(835-837)TGG>TAG	p.W279*		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	279	Homeobox.					nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GTTCTGGTACCAGGTCTTGAC	0.547													43	52					0	0	0	0
KIRREL	55243	broad.mit.edu	37	1	158047873	158047873	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:158047873G>T	uc001frn.3	+	3	699	c.295G>T	c.(295-297)GAG>TAG	p.E99*	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Nonsense_Mutation_p.E38*	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	99	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CGCCTCTTACGAGTGCCAGGC	0.627													35	87					1.60099e-16	2.11656e-16	1	0
CRP	1401	broad.mit.edu	37	1	159683905	159683905	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:159683905A>G	uc001ftw.2	-	2	189	c.85T>C	c.(85-87)TTT>CTT	p.F29L	CRP_uc001ftx.1_Missense_Mutation_p.F29L|CRP_uc001fty.1_5'Flank	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	29	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TCTTTGGGAAACACAAAAGCC	0.458													11	78					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171505303	171505303	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:171505303C>T	uc010pmg.1	+	14	2439	c.2173C>T	c.(2173-2175)CCT>TCT	p.P725S		NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	725	Pro-rich.						protein C-terminus binding				0						GCAGCCTCATCCTCAGCATTT	0.478													6	15					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563768	176563768	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:176563768G>T	uc001gkz.2	+	3	2192	c.1028G>T	c.(1027-1029)TGC>TTC	p.C343F	PAPPA2_uc001gky.1_Missense_Mutation_p.C343F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	343					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTCTCCCTCTGCACCGACCGC	0.577													14	55					6.31663e-08	7.49349e-08	1	0
FAM5B	57795	broad.mit.edu	37	1	177245369	177245369	+	Missense_Mutation	SNP	C	G	G	rs145109858	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:177245369C>G	uc001glf.2	+	6	1123	c.811C>G	c.(811-813)CGC>GGC	p.R271G	FAM5B_uc010pna.1_Missense_Mutation_p.R21G|FAM5B_uc001glg.2_Missense_Mutation_p.R166G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	271						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCTGCGTGAGCGCTTTGTAGC	0.562													9	61					0	0	0	0
C1orf125	126859	broad.mit.edu	37	1	179363133	179363133	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:179363133T>A	uc001gmo.2	+	10	1086	c.959T>A	c.(958-960)TTA>TAA	p.L320*	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Nonsense_Mutation_p.L108*|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Nonsense_Mutation_p.L320*	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	320	Potential.										0						CAGCGCATTTTAGAAGAATTG	0.373													22	52					0	0	0	0
CFHR4	10877	broad.mit.edu	37	1	196883745	196883745	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:196883745C>G	uc001gto.2	+	4	629	c.560C>G	c.(559-561)ACC>AGC	p.T187S	CFHR4_uc009wyy.2_Missense_Mutation_p.T433S|CFHR4_uc001gtp.2_Missense_Mutation_p.T434S	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	187	Sushi 3.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TATGGAAACACCACAGGTTCC	0.358													7	43					0	0	0	0
ZNF281	23528	broad.mit.edu	37	1	200378334	200378334	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:200378334T>A	uc001gve.2	-	2	607	c.500A>T	c.(499-501)GAA>GTA	p.E167V	uc010ppi.1_5'Flank|ZNF281_uc001gvf.1_Missense_Mutation_p.E167V|ZNF281_uc001gvg.1_Missense_Mutation_p.E131V	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	167					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ACTCCCCCCTTCACCGCCTCC	0.527													10	67					0	0	0	0
KLHL12	59349	broad.mit.edu	37	1	202887471	202887471	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:202887471G>A	uc001gyo.1	-	4	595	c.395C>T	c.(394-396)CCT>CTT	p.P132L	KLHL12_uc001gyn.1_5'UTR|KLHL12_uc010pqc.1_Missense_Mutation_p.P170L|KLHL12_uc009xah.1_Missense_Mutation_p.P132L	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	132					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAATTAGAAGGGTCCAACTG	0.448													12	57					0	0	0	0
EDARADD	128178	broad.mit.edu	37	1	236590709	236590709	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:236590709A>G	uc001hxu.1	+	4	243	c.178A>G	c.(178-180)ATT>GTT	p.I60V	EDARADD_uc001hxv.1_Missense_Mutation_p.I50V	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	60					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATGTGATACAATTACTTTGAA	0.229													3	8					0	0	0	0
CHRM3	1131	broad.mit.edu	37	1	240071629	240071629	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:240071629A>G	uc001hyp.2	+	5	1657	c.878A>G	c.(877-879)TAC>TGC	p.Y293C		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	293	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGCAGCAGTTACGAACTTCAA	0.547													7	63					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240492727	240492727	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:240492727T>A	uc010pyd.1	+	10	4621	c.4396T>A	c.(4396-4398)TCA>ACA	p.S1466T	FMN2_uc010pye.1_Missense_Mutation_p.S1470T|FMN2_uc010pyf.1_Missense_Mutation_p.S112T|FMN2_uc010pyg.1_Missense_Mutation_p.S62T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1466	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGCATTTGCTCAATTCGTCG	0.408													13	78					0	0	0	0
ANKRD16	54522	broad.mit.edu	37	10	5929887	5929887	+	Missense_Mutation	SNP	A	G	G	rs112121948		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:5929887A>G	uc010qat.1	-	2	1001	c.458T>C	c.(457-459)CTC>CCC	p.L153P	ANKRD16_uc009xie.2_Missense_Mutation_p.L153P|ANKRD16_uc009xif.2_Missense_Mutation_p.L153P|ANKRD16_uc001iiq.2_Missense_Mutation_p.L153P|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	153	ANK 4.										0						CAGGTACTGGAGGATCAGAGG	0.532													13	54					0	0	0	0
ARMC4	55130	broad.mit.edu	37	10	28151364	28151364	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:28151364G>C	uc009xky.2	-	18	2896	c.2798C>G	c.(2797-2799)ACA>AGA	p.T933R	ARMC4_uc010qds.1_Missense_Mutation_p.T458R|ARMC4_uc010qdt.1_Missense_Mutation_p.T625R|ARMC4_uc001itz.2_Missense_Mutation_p.T933R	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	933	ARM 8.						binding			ovary(4)|skin(2)	6						GTTACTTACTGTATTTGCCAG	0.244													16	36					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317109	30317109	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:30317109T>A	uc001iux.2	-	2	2027	c.1968A>T	c.(1966-1968)GAA>GAT	p.E656D	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E518D|KIAA1462_uc009xle.1_Missense_Mutation_p.E656D	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	656										ovary(4)	4						GTCTGTCTTCTTCTGGTTCCC	0.522													11	47					0	0	0	0
EGR2	1959	broad.mit.edu	37	10	64575770	64575770	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:64575770A>G	uc010qim.1	-	2	174	c.20T>C	c.(19-21)GTA>GCA	p.V7A	EGR2_uc010qin.1_Intron|EGR2_uc001jmi.2_Missense_Mutation_p.V7A|EGR2_uc010qio.1_Intron|EGR2_uc009xph.2_Missense_Mutation_p.V7A	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	7					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GATTTTGTCTACGGCCTTGGC	0.562													72	90					0	0	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974163	64974163	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:64974163G>C	uc001jmn.2	-	8	2064	c.1764C>G	c.(1762-1764)CAC>CAG	p.H588Q	JMJD1C_uc001jml.2_Missense_Mutation_p.H369Q|JMJD1C_uc001jmm.2_Missense_Mutation_p.H300Q|JMJD1C_uc010qiq.1_Missense_Mutation_p.H406Q|JMJD1C_uc009xpi.2_Missense_Mutation_p.H406Q|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.H300Q	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	588					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCATGTTCAAGTGATCATTTC	0.393													5	35					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95791986	95791986	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:95791986C>T	uc001kjk.2	+	2	1817	c.1183C>T	c.(1183-1185)CTG>TTG	p.L395L	PLCE1_uc010qnx.1_Silent_p.L395L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	395					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GAGCCAACGTCTGTCAGAAGC	0.408													5	37					0	0	0	0
CC2D2B	387707	broad.mit.edu	37	10	97769618	97769618	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:97769618A>G	uc001kll.2	+	3	257	c.58A>G	c.(58-60)ATA>GTA	p.I20V	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_RNA|CC2D2B_uc010qop.1_Missense_Mutation_p.I20V	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	20										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TCACTCATATATAAGAAAGAA	0.318													4	30					0	0	0	0
ABCC2	1244	broad.mit.edu	37	10	101578649	101578649	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:101578649G>T	uc001kqf.2	+	18	2513	c.2374G>T	c.(2374-2376)GAT>TAT	p.D792Y		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	792	Cytoplasmic (By similarity).|ABC transporter 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCTGCAGTGGATGCTCATGT	0.433													30	22					4.43304e-23	6.11994e-23	1	0
PAX2	5076	broad.mit.edu	37	10	102584502	102584502	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:102584502G>A	uc001krk.3	+	9	1636	c.1086G>A	c.(1084-1086)GTG>GTA	p.V362V	PAX2_uc001krl.3_Silent_p.V339V|PAX2_uc001krm.3_Silent_p.V362V|PAX2_uc001kro.3_Silent_p.V339V|PAX2_uc001krn.3_Silent_p.V339V|PAX2_uc010qps.1_Silent_p.V338V|PAX2_uc001krp.1_Silent_p.V335V	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	362					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CAGGAATGGTGCCTGGTAGGT	0.617													21	99					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103342623	103342623	+	Missense_Mutation	SNP	C	A	A	rs146112511		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:103342623C>A	uc001ktg.1	-	6	1857	c.1091G>T	c.(1090-1092)CGC>CTC	p.R364L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Missense_Mutation_p.R37L|POLL_uc001kte.1_Missense_Mutation_p.R56L|POLL_uc001kth.1_Missense_Mutation_p.R89L|POLL_uc001kti.1_Missense_Mutation_p.R364L|POLL_uc001ktj.1_Missense_Mutation_p.R364L|POLL_uc001ktf.2_Missense_Mutation_p.R272L|POLL_uc001ktk.1_Missense_Mutation_p.R103L|POLL_uc010qqa.1_Missense_Mutation_p.R103L|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Missense_Mutation_p.R364L|POLL_uc001ktl.2_Missense_Mutation_p.R276L|POLL_uc010qqc.1_Missense_Mutation_p.R56L	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	364					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GGCCTGGCTGCGGATGTCTTC	0.552								DNA_polymerases_(catalytic_subunits)					14	89					3.27435e-08	3.91417e-08	1	0
GBF1	8729	broad.mit.edu	37	10	104018750	104018750	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:104018750G>A	uc001kux.1	+	2	295	c.55G>A	c.(55-57)GCC>ACC	p.A19T	GBF1_uc001kuw.2_Missense_Mutation_p.A19T|GBF1_uc001kuy.1_Missense_Mutation_p.A19T|GBF1_uc001kuz.1_Missense_Mutation_p.A19T	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	19					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TGTGGTTGGGGCCATCAAACG	0.408													19	138					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	117849257	117849257	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:117849257A>T	uc001lcj.2	-	9	1890	c.1192T>A	c.(1192-1194)TTA>ATA	p.L398I	GFRA1_uc001lci.2_Missense_Mutation_p.L393I|GFRA1_uc009xyr.2_Missense_Mutation_p.L393I	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	398					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTCACCTGTAAATTTGCACAC	0.547													19	126					0	0	0	0
KCNK18	338567	broad.mit.edu	37	10	118957108	118957108	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:118957108G>T	uc010qsr.1	+	1	109	c.109G>T	c.(109-111)GGT>TGT	p.G37C		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	37	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CGCCCTGGTGGGTGCTGTGGT	0.597													29	27					9.39395e-14	1.22121e-13	1	0
PWWP2B	170394	broad.mit.edu	37	10	134218293	134218293	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:134218293A>C	uc001lll.3	+	2	318	c.289A>C	c.(289-291)ACC>CCC	p.T97P	PWWP2B_uc009ybe.2_Missense_Mutation_p.T97P	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	97	Pro-rich.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		CCCCGAGACCACCCGCCCCGA	0.756													6	17					0	0	0	0
INPP5A	3632	broad.mit.edu	37	10	134464009	134464009	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:134464009G>T	uc001llp.2	+	4	554	c.306G>T	c.(304-306)ACG>ACT	p.T102T	INPP5A_uc001llo.1_Silent_p.T102T|INPP5A_uc001llq.2_Silent_p.T54T	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	102					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		AGCACTTCACGGTGAGTCCCT	0.542													62	70					3.74213e-36	5.33125e-36	1	0
CYP2E1	1571	broad.mit.edu	37	10	135346244	135346244	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:135346244A>T	uc001lnj.1	+	5	730	c.697A>T	c.(697-699)AGA>TGA	p.R233*	CYP2E1_uc001lnk.1_Nonsense_Mutation_p.R96*|CYP2E1_uc009ybl.1_Nonsense_Mutation_p.R34*|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Nonsense_Mutation_p.R34*	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	233					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TGGAAGCCACAGAAAAGTCAT	0.408									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				26	174					0	0	0	0
MOB2	81532	broad.mit.edu	37	11	1491670	1491670	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:1491670C>G	uc010qwz.1	-	5	729	c.539G>C	c.(538-540)AGA>ACA	p.R180T	MOB2_uc001lto.1_Missense_Mutation_p.R64T|MOB2_uc001ltp.1_5'UTR|MOB2_uc001ltq.1_Missense_Mutation_p.R143T|MOB2_uc010qwy.1_Missense_Mutation_p.R64T	NM_053005	NP_443731	Q70IA6	MOB2_HUMAN	HCCA2 protein	149						nucleus|perinuclear region of cytoplasm	metal ion binding				0						GAACAGGTGTCTGCAGATCTT	0.587													27	54					0	0	0	0
OR52E2	119678	broad.mit.edu	37	11	5080588	5080588	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:5080588G>T	uc010qyw.1	-	1	270	c.270C>A	c.(268-270)AAC>AAA	p.N90K		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCCCTCTGAGGTTGATCCAGA	0.483													15	25					2.31682e-05	2.54524e-05	1	0
SLC5A12	159963	broad.mit.edu	37	11	26695058	26695058	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:26695058T>G	uc001mra.2	-	14	1911	c.1598A>C	c.(1597-1599)GAT>GCT	p.D533A	SLC5A12_uc001mrb.2_RNA	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	533	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TGGTTGAATATCCTCACCTCT	0.373													13	103					0	0	0	0
EXT2	2132	broad.mit.edu	37	11	44228424	44228424	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:44228424A>G	uc001mxz.2	+	10	1911	c.1577A>G	c.(1576-1578)TAT>TGT	p.Y526C	EXT2_uc010rfo.1_Missense_Mutation_p.Y554C|EXT2_uc001mxy.2_Missense_Mutation_p.Y539C|EXT2_uc009ykt.2_Missense_Mutation_p.Y536C|EXT2_uc001mya.2_Missense_Mutation_p.Y559C	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	526	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TTCTTCCCTTATGATGAAATC	0.413			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				28	52					0	0	0	0
CHST1	8534	broad.mit.edu	37	11	45672189	45672189	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:45672189G>A	uc001mys.1	-	4	956	c.285C>T	c.(283-285)CAC>CAT	p.H95H		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	95	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TGTTCTGGACGTGGTAGAGGG	0.657													30	72					0	0	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332681	46332681	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:46332681A>G	uc001ncf.2	+	5	1129	c.694A>G	c.(694-696)AGG>GGG	p.R232G		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	232	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CAGCCCTGTCAGGCCCATGGC	0.667			T	FUS	myxofibrosarcoma								3	70					0	0	0	0
MADD	8567	broad.mit.edu	37	11	47306595	47306595	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:47306595G>A	uc001ner.1	+	13	2452	c.2261G>A	c.(2260-2262)CGT>CAT	p.R754H	MADD_uc001neq.2_Missense_Mutation_p.R754H|MADD_uc001nev.1_Missense_Mutation_p.R754H|MADD_uc001nes.1_Missense_Mutation_p.R754H|MADD_uc001net.1_Missense_Mutation_p.R754H|MADD_uc009yln.1_Missense_Mutation_p.R754H|MADD_uc001neu.1_Missense_Mutation_p.R754H|MADD_uc001nex.2_Missense_Mutation_p.R754H|MADD_uc001nez.2_Missense_Mutation_p.R754H|MADD_uc001new.2_Missense_Mutation_p.R754H	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	754					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GTGGACAGACGTCAGGCAGAA	0.557													6	90					0	0	0	0
CLP1	10978	broad.mit.edu	37	11	57428484	57428484	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:57428484T>C	uc001nkw.2	+	3	993	c.854T>C	c.(853-855)GTG>GCG	p.V285A	CLP1_uc010rjw.1_Missense_Mutation_p.V221A|CLP1_uc009yml.2_Missense_Mutation_p.V285A	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	285					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						TCTGGGGGTGTGGTGGAGCGC	0.512													3	144					0	0	0	0
MPEG1	219972	broad.mit.edu	37	11	58979531	58979531	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:58979531G>A	uc001nnu.3	-	1	964	c.808C>T	c.(808-810)CGA>TGA	p.R270*		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	270	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				GAGTTGGTTCGGTTTGAGAGG	0.532													4	16					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62293536	62293536	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:62293536C>A	uc001ntl.2	-	5	8653	c.8353G>T	c.(8353-8355)GAT>TAT	p.D2785Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2785					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACGTCCACATCTGGACCTTCT	0.498													66	135					1.31726e-23	1.8266e-23	1	0
MALAT1	378938	broad.mit.edu	37	11	65265869	65265869	+	RNA	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:65265869G>A	uc010roh.1	+	1		c.637G>A				NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						ACGGCCCCCGGGGCTCAGGCG	0.617													17	23					0	0	0	0
MTL5	9633	broad.mit.edu	37	11	68506204	68506204	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:68506204G>C	uc001ooc.2	-	6	1021	c.881C>G	c.(880-882)TCA>TGA	p.S294*	MTL5_uc001ood.1_Nonsense_Mutation_p.S294*|MTL5_uc009ysi.1_3'UTR	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	294					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TGGAAGAGTTGATCCCGAGGG	0.408													93	174					0	0	0	0
MTL5	9633	broad.mit.edu	37	11	68506237	68506237	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:68506237G>A	uc001ooc.2	-	6	988	c.848C>T	c.(847-849)TCG>TTG	p.S283L	MTL5_uc001ood.1_Missense_Mutation_p.S283L|MTL5_uc009ysi.1_3'UTR	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	283					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GTTGACTACCGATGGTAAGGC	0.438													78	157					0	0	0	0
MYEOV	26579	broad.mit.edu	37	11	69063820	69063820	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:69063820C>A	uc001oov.2	+	3	1353	c.903C>A	c.(901-903)CAC>CAA	p.H301Q	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.H301Q|MYEOV_uc001oow.2_Missense_Mutation_p.H243Q	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	301											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		tcctccaccacctcctcctcc	0.269													19	8					0.00074312	0.000799495	1	0
TRIM49	57093	broad.mit.edu	37	11	89537595	89537595	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:89537595A>G	uc001pdb.2	-	3	372	c.43T>C	c.(43-45)TGC>CGC	p.C15R		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	15	RING-type.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CACAGGGGGCAGATGAGTTCC	0.473													12	31					0	0	0	0
UBTFL1	642623	broad.mit.edu	37	11	89819398	89819398	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:89819398G>T	uc010rub.1	+	1	281	c.281G>T	c.(280-282)AGG>ATG	p.R94M		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	94					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						CAAAAATACAGGAACGGTCCA	0.423													10	9					4.68919e-08	5.58407e-08	1	0
FAT3	120114	broad.mit.edu	37	11	92088310	92088310	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92088310G>T	uc001pdj.3	+	1	3049	c.3032G>T	c.(3031-3033)CGG>CTG	p.R1011L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1011	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTACTGTGCGGGCCAAAGAC	0.453										TCGA Ovarian(4;0.039)			12	24					5.50884e-06	6.16042e-06	1	0
FAT3	120114	broad.mit.edu	37	11	92523307	92523307	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92523307G>T	uc001pdj.3	+	7	4551	c.4534G>T	c.(4534-4536)GAC>TAC	p.D1512Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1512	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCGGATTGACCCTAGCAC	0.488										TCGA Ovarian(4;0.039)			20	107					2.37509e-13	3.037e-13	1	0
FAT3	120114	broad.mit.edu	37	11	92573756	92573756	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92573756T>C	uc001pdj.3	+	17	10414	c.10397T>C	c.(10396-10398)TTG>TCG	p.L3466S	FAT3_uc001pdi.3_5'UTR	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3466	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACCAGCATCTTGCAGCTGGTG	0.388										TCGA Ovarian(4;0.039)			12	28					0	0	0	0
OR6M1	390261	broad.mit.edu	37	11	123676665	123676665	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:123676665C>A	uc010rzz.1	-	1	393	c.393G>T	c.(391-393)ACG>ACT	p.T131T		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TCATGATGACCGTGTAGTGCA	0.517													19	20					1.64113e-05	1.80931e-05	1	0
CD163L1	283316	broad.mit.edu	37	12	7556294	7556294	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:7556294G>A	uc001qsy.2	-	6	1271	c.1245C>T	c.(1243-1245)AGC>AGT	p.S415S	CD163L1_uc010sge.1_Silent_p.S425S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	415	SRCR 4.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCCAAAGACGCTGAACGGAC	0.458													42	128					0	0	0	0
PZP	5858	broad.mit.edu	37	12	9317736	9317736	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:9317736C>A	uc001qvl.2	-	19	2515	c.2486G>T	c.(2485-2487)CGG>CTG	p.R829L	PZP_uc009zgl.2_Missense_Mutation_p.R698L|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Missense_Mutation_p.R161L	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTCCTTACCCGGATGCATTT	0.463													17	71					5.35267e-07	6.1853e-07	1	0
PRB3	5544	broad.mit.edu	37	12	11420652	11420652	+	Silent	SNP	C	T	T	rs74786167		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:11420652C>T	uc001qzs.2	-	3	569	c.531G>A	c.(529-531)CCG>CCA	p.P177P	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	177	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.|6.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			CCGGATGAGGCGGGGGACCTT	0.642													7	186					0	0	0	0
PTPRO	5800	broad.mit.edu	37	12	15637161	15637161	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:15637161G>T	uc001rcv.1	+	2	503	c.329G>T	c.(328-330)AGA>ATA	p.R110I	PTPRO_uc001rcw.1_Missense_Mutation_p.R110I|PTPRO_uc001rcu.1_Missense_Mutation_p.R110I	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	110	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAGCCATCCAGATCAATCACT	0.413													10	38					7.48243e-07	8.61446e-07	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21030851	21030851	+	Silent	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:21030851T>A	uc001rek.2	+	9	1242	c.1116T>A	c.(1114-1116)TCT>TCA	p.S372S	SLCO1B3_uc001rel.2_Silent_p.S372S|SLCO1B3_uc010sil.1_Silent_p.S372S|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.S197S	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	372	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AGTCTGCATCTCATGCTAACT	0.328													17	53					0	0	0	0
IFLTD1	160492	broad.mit.edu	37	12	25672821	25672821	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:25672821C>A	uc001rgs.2	-	6	1074	c.924G>T	c.(922-924)CAG>CAT	p.Q308H	IFLTD1_uc001rgt.1_Missense_Mutation_p.Q211H|IFLTD1_uc010sji.1_Missense_Mutation_p.Q329H|IFLTD1_uc010sjj.1_Missense_Mutation_p.Q245H|IFLTD1_uc009zjc.2_Missense_Mutation_p.Q289H	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	308						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					CTTGTTCCACCTGATAATTTG	0.388													6	32					1.06961e-07	1.26409e-07	1	0
OVCH1	341350	broad.mit.edu	37	12	29597152	29597152	+	Silent	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:29597152A>G	uc001rix.1	-	24	2943	c.2943T>C	c.(2941-2943)CCT>CCC	p.P981P		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	981					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CATCCTCACAAGGGACCAAGT	0.403													3	178					0	0	0	0
CNTN1	1272	broad.mit.edu	37	12	41312540	41312540	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:41312540G>T	uc001rmm.1	+	4	307	c.194G>T	c.(193-195)TGT>TTT	p.C65F	CNTN1_uc009zjy.1_Missense_Mutation_p.C65F|CNTN1_uc001rmn.1_Missense_Mutation_p.C54F|CNTN1_uc001rmo.2_Missense_Mutation_p.C65F	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	65	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TCACTCAACTGTAGGGCACGA	0.438													8	60					3.09899e-07	3.60777e-07	1	0
IRAK4	51135	broad.mit.edu	37	12	44180289	44180289	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:44180289G>A	uc001rnu.3	+	12	1406	c.1276G>A	c.(1276-1278)GTT>ATT	p.V426I	IRAK4_uc001rnt.3_Missense_Mutation_p.V426I|IRAK4_uc001rnx.3_Missense_Mutation_p.V302I|IRAK4_uc001rny.3_Missense_Mutation_p.V302I|IRAK4_uc010sky.1_Missense_Mutation_p.V302I|IRAK4_uc001rnv.3_Missense_Mutation_p.V302I|IRAK4_uc001rnw.3_Missense_Mutation_p.V302I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	426	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TTCCACTTCAGTTGAAGCTAT	0.284													16	87					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52056869	52056869	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:52056869A>T	uc001ryw.2	+	2	446	c.268A>T	c.(268-270)ACG>TCG	p.T90S		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	90					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATACTATTTGACGCAGAAAGT	0.527													51	92					0	0	0	0
MBD6	114785	broad.mit.edu	37	12	57918502	57918502	+	Splice_Site	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:57918502G>A	uc001soj.1	+	4	338	c.114_splice	c.e4-1	p.S38_splice	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6							chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						TCCTCTCGCAGTCCAAGTGGC	0.542													39	47					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72956711	72956711	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:72956711A>G	uc001sxa.2	+	9	1828	c.1798A>G	c.(1798-1800)ATC>GTC	p.I600V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	600	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTATCCTGTTATCACCATCTT	0.328													9	70					0	0	0	0
KCNC2	3747	broad.mit.edu	37	12	75601187	75601187	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:75601187C>G	uc001sxg.1	-	2	1121	c.577G>C	c.(577-579)GAG>CAG	p.E193Q	KCNC2_uc009zry.2_Missense_Mutation_p.E193Q|KCNC2_uc001sxe.2_Missense_Mutation_p.E193Q|KCNC2_uc001sxf.2_Missense_Mutation_p.E193Q|KCNC2_uc010stw.1_Missense_Mutation_p.E193Q	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	193	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.E193D(1)		breast(2)|pancreas(2)|skin(1)|lung(1)	6						GCCGCGTCCTCGATGCCCAGC	0.721													4	22					0	0	0	0
GLIPR1	11010	broad.mit.edu	37	12	75892486	75892486	+	Missense_Mutation	SNP	G	A	A	rs3736392	by1000genomes	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:75892486G>A	uc001sxs.2	+	5	780	c.632G>A	c.(631-633)CGA>CAA	p.R211Q	GLIPR1_uc009zsb.1_Missense_Mutation_p.E235K|KRR1_uc001sxt.2_3'UTR|KRR1_uc009zsc.2_3'UTR	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	211					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						AACCGACAGCGAGACCAAGTC	0.323													11	34					0	0	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80226236	80226236	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:80226236G>A	uc001syz.2	-	4	790	c.523C>T	c.(523-525)CGG>TGG	p.R175W	PPP1R12A_uc010suc.1_Missense_Mutation_p.R88W|PPP1R12A_uc001sza.2_Missense_Mutation_p.R175W|PPP1R12A_uc010sud.1_Missense_Mutation_p.R175W|PPP1R12A_uc001szb.2_Missense_Mutation_p.R175W|PPP1R12A_uc001szc.2_Missense_Mutation_p.R175W	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	175						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						AGCATGATCCGTTCTTCTTCC	0.388													21	114					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81472018	81472018	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:81472018C>T	uc001szl.1	+	1	210	c.119C>T	c.(118-120)CCG>CTG	p.P40L	ACSS3_uc001szm.1_Missense_Mutation_p.P40L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	40						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTAGTGGTCCCGGGCCCGCGG	0.731													3	19					0	0	0	0
TMTC2	160335	broad.mit.edu	37	12	83250841	83250841	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:83250841A>G	uc001szt.2	+	2	568	c.136A>G	c.(136-138)ATT>GTT	p.I46V	TMTC2_uc001szr.1_Missense_Mutation_p.I46V|TMTC2_uc001szs.1_Missense_Mutation_p.I46V|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	46						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						ATGGACGCACATTTTCTACAA	0.428													61	117					0	0	0	0
APAF1	317	broad.mit.edu	37	12	99056319	99056319	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:99056319G>T	uc001tfz.2	+	6	1373	c.796G>T	c.(796-798)GAC>TAC	p.D266Y	APAF1_uc001tfy.2_Missense_Mutation_p.D255Y|APAF1_uc001tga.2_Missense_Mutation_p.D255Y|APAF1_uc001tgb.2_Missense_Mutation_p.D266Y|APAF1_uc001tgc.2_Missense_Mutation_p.D266Y	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	266	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TACAACCAGAGACAAGAGTGT	0.308													17	25					2.48551e-13	3.16521e-13	1	0
ANO4	121601	broad.mit.edu	37	12	101381432	101381432	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:101381432C>A	uc010svm.1	+	8	1290	c.718C>A	c.(718-720)CAG>AAG	p.Q240K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.Q205K|ANO4_uc001thx.2_Missense_Mutation_p.Q240K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	240	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CCCTTTCAGCCAGCAAAGGAT	0.527										HNSCC(74;0.22)	OREG0022059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	142					8.16721e-17	1.08433e-16	1	0
CCDC92	80212	broad.mit.edu	37	12	124421993	124421993	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:124421993C>T	uc001ufw.1	-	5	755	c.608G>A	c.(607-609)CGC>CAC	p.R203H	CCDC92_uc001ufv.1_Missense_Mutation_p.R186H|CCDC92_uc001ufx.1_Missense_Mutation_p.R203H|CCDC92_uc001ufy.1_Missense_Mutation_p.R186H	NM_025140	NP_079416	Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	203											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		CATGCGGCGGCGAGGCGTTTC	0.612													33	51					0	0	0	0
N6AMT2	221143	broad.mit.edu	37	13	21311925	21311925	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:21311925T>C	uc001uno.1	-	3	245	c.164A>G	c.(163-165)TAT>TGT	p.Y55C	N6AMT2_uc009zzr.1_Missense_Mutation_p.Y55C|N6AMT2_uc001unp.2_Intron	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	55							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTCCTGACTATACCAAAACTG	0.393													13	16					0	0	0	0
FLT1	2321	broad.mit.edu	37	13	28931821	28931821	+	Silent	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:28931821T>A	uc001usb.3	-	15	2403	c.2118A>T	c.(2116-2118)GGA>GGT	p.G706G		NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	706	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTAAAATAATTCCTGAGGGGT	0.443													64	50					0	0	0	0
SIAH3	283514	broad.mit.edu	37	13	46357673	46357673	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:46357673G>A	uc001vap.2	-	2	737	c.655C>T	c.(655-657)CGG>TGG	p.R219W		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	219					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						AGAACAGACCGGGGCGTGGCC	0.617													22	26					0	0	0	0
THSD1P1	374500	broad.mit.edu	37	13	52742144	52742144	+	RNA	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:52742144G>A	uc001vgk.2	-	9		c.2454C>T			THSD1P1_uc001vgm.1_RNA|THSD1P1_uc010adx.1_RNA|THSD1P1_uc010ady.1_RNA|THSD1P1_uc001vgl.1_RNA					Homo sapiens cDNA FLJ14630 fis, clone NT2RP2000459.												0						CTCTTCATTTGACCCAAAATA	0.507													8	11					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329467	88329467	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:88329467G>A	uc001vln.2	+	2	2043	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	SLITRK5_uc010tic.1_Silent_p.S367S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	608	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCATTAAGTCGGAGCTGCTGT	0.582													23	154					0	0	0	0
NALCN	259232	broad.mit.edu	37	13	101997697	101997697	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:101997697G>T	uc001vox.1	-	7	908	c.719C>A	c.(718-720)CCA>CAA	p.P240Q	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.P240Q|NALCN_uc001vpa.2_Missense_Mutation_p.P240Q	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	240	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAATCCAGGTGGGCACTGGTA	0.448													51	42					5.13769e-22	7.03052e-22	1	0
IRS2	8660	broad.mit.edu	37	13	110436062	110436062	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:110436062G>A	uc001vqv.2	-	1	2853	c.2339C>T	c.(2338-2340)CCG>CTG	p.P780L		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	780					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GAAGTCGGGCGGGGTGCCCGT	0.692													7	3					0	0	0	0
METT11D1	64745	broad.mit.edu	37	14	21464756	21464757	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:21464756_21464757GC>AT	uc001vyn.2	+	13	1348_1349	c.1151_1152GC>AT	c.(1150-1152)CGC>CAT	p.R384H	METT11D1_uc001vym.2_Missense_Mutation_p.R384H|METT11D1_uc001vyo.2_Missense_Mutation_p.R384H|METT11D1_uc001vyp.2_Missense_Mutation_p.R226H|METT11D1_uc001vyq.2_Missense_Mutation_p.R226H|SLC39A2_uc001vyr.2_5'Flank|SLC39A2_uc001vys.2_5'Flank	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	384					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GAGGCTCATCGCTGGCCCCGTA	0.515													16	28					0	0	0	0
JPH4	84502	broad.mit.edu	37	14	24045142	24045142	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:24045142G>A	uc001wkq.2	-	4	1821	c.903C>T	c.(901-903)AAC>AAT	p.N301N	JPH4_uc010tnr.1_5'Flank|JPH4_uc001wkr.2_Silent_p.N301N|JPH4_uc001wks.2_Silent_p.N301N	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	301	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGCGCAGCCCGTTGGAGCGCT	0.677													5	25					0	0	0	0
C14orf21	161424	broad.mit.edu	37	14	24769788	24769788	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:24769788G>C	uc001wol.1	+	2	485	c.422G>C	c.(421-423)TGC>TCC	p.C141S	C14orf21_uc001wom.1_5'Flank|DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	141							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		TGTCACCGATGCGGGGTCCAT	0.483													48	128					0	0	0	0
NPAS3	64067	broad.mit.edu	37	14	33684540	33684540	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:33684540T>A	uc001wru.2	+	3	357	c.293T>A	c.(292-294)ATT>AAT	p.I98N	NPAS3_uc001wrs.2_Missense_Mutation_p.I68N|NPAS3_uc001wrt.2_Missense_Mutation_p.I68N|NPAS3_uc001wrv.2_Missense_Mutation_p.I68N|NPAS3_uc001wrw.2_5'UTR	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	98	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGACTTACAATTAGCTATCTG	0.463													34	66					0	0	0	0
LRFN5	145581	broad.mit.edu	37	14	42360587	42360587	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:42360587A>G	uc001wvm.2	+	4	2718	c.1520A>G	c.(1519-1521)CAG>CGG	p.Q507R	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	507	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GGTTGCATCCAGTTTACTACG	0.433										HNSCC(30;0.082)			25	95					0	0	0	0
GPR137C	283554	broad.mit.edu	37	14	53020234	53020234	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:53020234C>A	uc001wzu.3	+	1	369	c.369C>A	c.(367-369)CCC>CCA	p.P123P	TXNDC16_uc010tqu.1_5'Flank|TXNDC16_uc001wzs.2_5'Flank|TXNDC16_uc010aoe.2_5'Flank|GPR137C_uc001wzt.3_Silent_p.P123P	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	123	Helical; (Potential).					integral to membrane					0	Breast(41;0.0716)					ACTTCTTCCCCCACTGGCTGC	0.652													12	56					7.03913e-09	8.51243e-09	1	0
PSMC6	5706	broad.mit.edu	37	14	53173987	53173987	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:53173987T>C	uc010tqx.1	+	1	92	c.92T>C	c.(91-93)CTT>CCT	p.L31P	PSMC6_uc010tqv.1_Missense_Mutation_p.L31P|PSMC6_uc010tqw.1_Silent_p.L24L	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	17					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					AAGAAGTTGCTTGAACACAAG	0.537													7	30					0	0	0	0
RIN3	79890	broad.mit.edu	37	14	93118018	93118018	+	Silent	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:93118018C>G	uc001yap.2	+	6	776	c.624C>G	c.(622-624)TCC>TCG	p.S208S	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Silent_p.S133S|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	208					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCCTAGTCTCCAGCCTCAGGC	0.572													17	65					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	107083284	107083284	+	RNA	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:107083284G>C	uc010tyt.1	-	113		c.5509C>G								Parts of antibodies, mostly variable regions.												0						GGCCGTGTCCGCAGCGGTCAC	0.592													57	109					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24923749	24923749	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:24923749G>T	uc001ywo.2	+	1	3209	c.2735G>T	c.(2734-2736)AGT>ATT	p.S912I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	912					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AAGTCTGACAGTTCTTTTATT	0.488													42	114					1.07121e-22	1.47232e-22	1	0
Unknown	0	broad.mit.edu	37	15	25479262	25479262	+	5'Flank	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:25479262C>T	uc001zae.2	+						SNORD115-26_uc001yzw.1_RNA|SNORD115-35_uc001zac.1_5'Flank|SNORD115-11_uc001zad.1_5'Flank					Homo sapiens clone Rt-16 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																		CAGTGTACGTCAGCCAGGTGC	0.592													15	27					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	25940059	25940059	+	Missense_Mutation	SNP	G	A	A	rs147432497		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:25940059G>A	uc010ayu.2	-	14	3101	c.2995C>T	c.(2995-2997)CGC>TGC	p.R999C		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	999	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGGACGGAGCGGCACTGCTTG	0.597													12	42					0	0	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32921915	32921915	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:32921915G>T	uc001zgy.1	+	8	1779	c.1057G>T	c.(1057-1059)GAG>TAG	p.E353*	ARHGAP11A_uc010ubw.1_Nonsense_Mutation_p.E164*|ARHGAP11A_uc001zgw.2_Nonsense_Mutation_p.E353*|ARHGAP11A_uc001zgx.2_Nonsense_Mutation_p.E353*|ARHGAP11A_uc010ubx.1_Nonsense_Mutation_p.E164*	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	353					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTTTAACTTTGAGCTGTTGCC	0.353													11	33					1.08611e-07	1.27874e-07	1	0
THBS1	7057	broad.mit.edu	37	15	39886511	39886511	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:39886511G>T	uc001zkh.2	+	21	3554	c.3375G>T	c.(3373-3375)ATG>ATT	p.M1125I	THBS1_uc010bbi.2_Missense_Mutation_p.M597I	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	1125	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GAGTGGTGATGTATGAAGGGA	0.388													23	40					1.87028e-06	2.1066e-06	1	0
DLL4	54567	broad.mit.edu	37	15	41228746	41228746	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:41228746G>A	uc001zng.1	+	9	1881	c.1561G>A	c.(1561-1563)GTG>ATG	p.V521M		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	521	Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CGAGTTCCCCGTGGGCTTGCC	0.652													7	13					0	0	0	0
LTK	4058	broad.mit.edu	37	15	41804997	41804997	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:41804997C>T	uc001zoa.3	-	3	445	c.267G>A	c.(265-267)GCG>GCA	p.A89A	LTK_uc001zob.3_Silent_p.A89A|LTK_uc010ucx.1_Silent_p.A89A|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	89	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TCCCCGCGTACGCCCCGTCAC	0.692										TSP Lung(18;0.14)			5	26					0	0	0	0
ADAL	161823	broad.mit.edu	37	15	43638089	43638089	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:43638089G>A	uc010udo.1	+	9	1037	c.463G>A	c.(463-465)GTA>ATA	p.V155I	ADAL_uc001zrh.2_Missense_Mutation_p.V155I|ADAL_uc001zri.1_Missense_Mutation_p.V40I	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	155					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		TGGCCCTTTAGTAGCCAAGGA	0.408													28	49					0	0	0	0
SPG11	80208	broad.mit.edu	37	15	44890998	44890998	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:44890998C>A	uc001ztx.2	-	22	3754	c.3723G>T	c.(3721-3723)GGG>GGT	p.G1241G	SPG11_uc010ueh.1_Silent_p.G1241G|SPG11_uc010uei.1_Silent_p.G1241G|SPG11_uc001zty.1_5'UTR	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1241	Helical; (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGGAGGAGAGCCCTATAACAT	0.418													18	37					3.41278e-10	4.24218e-10	1	0
HERC1	8925	broad.mit.edu	37	15	63986610	63986610	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:63986610T>A	uc002amp.2	-	29	5529	c.5381A>T	c.(5380-5382)CAG>CTG	p.Q1794L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1794					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTGCAGGGGCTGTCCTAGCAT	0.473													18	40					0	0	0	0
IGDCC3	9543	broad.mit.edu	37	15	65667661	65667661	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:65667661C>A	uc002aos.2	-	2	435	c.183G>T	c.(181-183)CTG>CTT	p.L61L		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	61	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						CCCTGCAGTCCAGCACTATAG	0.592													9	28					3.07112e-06	3.44672e-06	1	0
MAP2K5	5607	broad.mit.edu	37	15	67873104	67873104	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:67873104G>T	uc002aqu.2	+	4	918	c.265G>T	c.(265-267)GTA>TTA	p.V89L	MAP2K5_uc002aqt.1_Missense_Mutation_p.V89L|MAP2K5_uc002aqv.2_Missense_Mutation_p.V89L|MAP2K5_uc010ujw.1_Missense_Mutation_p.V53L	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	89	OPR.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						TTATTCCACAGTAATGGAACA	0.333													22	54					4.47668e-21	6.07271e-21	1	0
ARNT2	9915	broad.mit.edu	37	15	80867386	80867386	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:80867386C>T	uc002bfr.2	+	14	1614	c.1448C>T	c.(1447-1449)GCG>GTG	p.A483V	ARNT2_uc010unm.1_Missense_Mutation_p.A472V|ARNT2_uc002bfs.2_Missense_Mutation_p.A472V	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	483					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GTGGAAAAGGCGGATGCAATC	0.473													5	131					0	0	0	0
SH3GL3	6457	broad.mit.edu	37	15	84255793	84255793	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:84255793A>T	uc002bjw.2	+	7	878	c.683A>T	c.(682-684)CAG>CTG	p.Q228L	SH3GL3_uc010uot.1_Missense_Mutation_p.Q228L|SH3GL3_uc002bjx.2_Missense_Mutation_p.Q159L|SH3GL3_uc002bju.2_Missense_Mutation_p.Q236L|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	228	BAR.|Interaction with ARC (By similarity).				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						TATCACAGACAGTCCACAGAG	0.502													5	17					0	0	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84506852	84506852	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:84506852C>A	uc002bjz.3	+	7	836	c.612C>A	c.(610-612)TGC>TGA	p.C204*	ADAMTSL3_uc002bjy.1_Nonsense_Mutation_p.C204*|ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.C204*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.C204*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	204						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGTGGGCTGCGATCGGCAAC	0.567													15	62					3.27435e-08	3.91417e-08	1	0
Unknown	0	broad.mit.edu	37	15	85787980	85787980	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:85787980T>G	uc010upj.1	+	6	788	c.723T>G	c.(721-723)CAT>CAG	p.H241Q	uc010upk.1_5'Flank	NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like																		TACGTGAACATGAGGAGAGGC	0.562													2	8					0	0	0	0
AXIN1	8312	broad.mit.edu	37	16	339603	339603	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:339603T>C	uc002cgp.1	-	10	2476	c.2299A>G	c.(2299-2301)AGA>GGA	p.R767G	AXIN1_uc002cgq.1_Missense_Mutation_p.R731G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	767	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CTCTGCGATCTTGTCCTGGGG	0.637													8	28					0	0	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1818367	1818367	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:1818367G>T	uc002cmk.2	+	30	3847	c.3727G>T	c.(3727-3729)GTC>TTC	p.V1243F	MAPK8IP3_uc002cml.2_Missense_Mutation_p.V1237F|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.V1244F	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1243					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GAAGTTCTTTGTCTCGGTGCC	0.652													27	60					1.5548e-18	2.08196e-18	1	0
E4F1	1877	broad.mit.edu	37	16	2273689	2273689	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:2273689G>A	uc002cpm.2	+	1	123	c.75G>A	c.(73-75)GCG>GCA	p.A25A	E4F1_uc010bsi.2_Silent_p.A25A|E4F1_uc010bsj.2_Silent_p.A25A	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	25					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GGCGGGAAGCGGGCGAGGGTG	0.741													4	18					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2333222	2333222	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:2333222C>A	uc002cpy.1	-	26	4712	c.4000G>T	c.(4000-4002)GGC>TGC	p.G1334C	ABCA3_uc010bsk.1_Missense_Mutation_p.G1276C	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1334					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CAGAGGATGCCCCTGAGTCTC	0.672													23	39					3.8784e-16	5.10575e-16	1	0
SRL	6345	broad.mit.edu	37	16	4242554	4242554	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:4242554C>G	uc002cvz.3	-	6	1035	c.1022G>C	c.(1021-1023)CGC>CCC	p.R341P	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	800						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						GGCGTGGATGCGGACCCGGAT	0.512													45	138					0	0	0	0
FAM86A	196483	broad.mit.edu	37	16	5143491	5143491	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:5143491G>T	uc002cyo.2	-	3	283	c.234C>A	c.(232-234)ATC>ATA	p.I78I	FAM86A_uc002cyp.2_Silent_p.I78I	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	78											0						TGACCTTTTTGATGAGTTCTG	0.458													9	43					2.74318e-10	3.42349e-10	1	0
RBBP6	5930	broad.mit.edu	37	16	24567192	24567192	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:24567192G>A	uc002dmh.2	+	6	1528	c.488G>A	c.(487-489)CGT>CAT	p.R163H	RBBP6_uc010vcb.1_Missense_Mutation_p.R30H|RBBP6_uc002dmi.2_Missense_Mutation_p.R163H|RBBP6_uc010bxr.2_Missense_Mutation_p.R163H|RBBP6_uc002dmk.2_Missense_Mutation_p.R30H	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	163	CCHC-type.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		ACGTGTTTCCGTTGTGGTAAA	0.358													10	19					0	0	0	0
CDIPT	10423	broad.mit.edu	37	16	29872572	29872572	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:29872572A>T	uc002dum.2	-	3	587	c.187T>A	c.(187-189)TTT>ATT	p.F63I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CDIPT_uc002duk.2_Missense_Mutation_p.F87I|CDIPT_uc002dul.2_Missense_Mutation_p.F35I|CDIPT_uc002dun.2_Missense_Mutation_p.F18I|LOC440356_uc010veb.1_5'Flank|LOC440356_uc002duo.2_5'Flank	NM_006319	NP_006310	O14735	CDIPT_HUMAN	CDP-diacylglycerol-inositol	63						endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|phosphatidylinositol transporter activity				0						ATGGCCCCAAACCGGGTTCCT	0.562													10	25					0	0	0	0
ITGAL	3683	broad.mit.edu	37	16	30490651	30490651	+	Splice_Site	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:30490651G>A	uc002dyi.3	+	6	622	c.446_splice	c.e6-1	p.E149_splice	ITGAL_uc010veu.1_Intron|ITGAL_uc002dyj.3_Intron|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor						blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GGCTTCTGCAGAATGTATCAA	0.473													23	40					0	0	0	0
NLRC5	84166	broad.mit.edu	37	16	57067576	57067576	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:57067576G>A	uc002ekk.1	+	12	2763	c.2538G>A	c.(2536-2538)ACG>ACA	p.T846T	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Silent_p.T595T|NLRC5_uc002ekl.2_Silent_p.T651T|NLRC5_uc002ekm.2_Silent_p.T651T|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	846					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GAAGCTTGACGCTCAGGTACC	0.547													21	54					0	0	0	0
HTA	283902	broad.mit.edu	37	16	73127500	73127500	+	RNA	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:73127500G>C	uc010vmq.1	+	3		c.906G>C				NR_027756				Homo sapiens cDNA clone IMAGE:4544545, partial cds.												0						GTCGTCTCCTGCAAACAGACA	0.537													4	8					0	0	0	0
CHST6	4166	broad.mit.edu	37	16	75512874	75512874	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:75512874G>A	uc002fef.2	-	3	1033	c.853C>T	c.(853-855)CGT>TGT	p.R285C	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R285C	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	285	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TAGAGCGCACGGATTTCTGCC	0.677													6	85					0	0	0	0
HSDL1	83693	broad.mit.edu	37	16	84163848	84163848	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:84163848G>A	uc002fhk.2	-	4	593	c.409C>T	c.(409-411)CGA>TGA	p.R137*	HSDL1_uc010vnv.1_Intron	NM_031463	NP_113651	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1 isoform a	137						mitochondrion	oxidoreductase activity|protein binding				0						AGGGCTTCTCGAATTGGAAGG	0.473													8	151					0	0	0	0
VPS53	55275	broad.mit.edu	37	17	465756	465756	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:465756C>A	uc002frn.2	-	14	1690	c.1543G>T	c.(1543-1545)GGC>TGC	p.G515C	VPS53_uc002frk.2_Missense_Mutation_p.G34C|VPS53_uc010cjo.1_Missense_Mutation_p.G515C|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.G486C|VPS53_uc002fro.2_Missense_Mutation_p.G317C|VPS53_uc010cjp.1_Missense_Mutation_p.G238C	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	515					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGCAGGTTGCCAGAGAGGATT	0.478													22	59					1.85244e-09	2.25766e-09	1	0
ZZEF1	23140	broad.mit.edu	37	17	3926063	3926063	+	Silent	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:3926063C>G	uc002fxe.2	-	44	7216	c.7152G>C	c.(7150-7152)CTG>CTC	p.L2384L	ZZEF1_uc002fxh.2_Silent_p.L698L|ZZEF1_uc002fxi.2_Silent_p.L619L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2384							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTTTTTCACCAGCAACTTCA	0.498													15	44					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	54					3.65163e-15	4.78701e-15	1	0
MYH13	8735	broad.mit.edu	37	17	10263357	10263357	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:10263357T>C	uc002gmk.1	-	7	655	c.565A>G	c.(565-567)ACC>GCC	p.T189A		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	189	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACACGCTTGGTGTTCACAGTC	0.512													15	57					0	0	0	0
MYH3	4621	broad.mit.edu	37	17	10535187	10535187	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:10535187T>A	uc002gmq.1	-	34	5180	c.5103A>T	c.(5101-5103)AAA>AAT	p.K1701N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1701	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GTTCCGCCAGTTTCCGGGCCC	0.637													10	61					0	0	0	0
ELAC2	60528	broad.mit.edu	37	17	12905653	12905653	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:12905653C>A	uc002gnz.3	-	14	1337	c.1242G>T	c.(1240-1242)GTG>GTT	p.V414V	ELAC2_uc002gnu.3_5'Flank|ELAC2_uc002gnv.3_Silent_p.V42V|ELAC2_uc002gnw.3_Silent_p.V72V|ELAC2_uc002gnx.3_Silent_p.V174V|ELAC2_uc010vvo.1_Silent_p.V212V|ELAC2_uc010vvp.1_Silent_p.V395V|ELAC2_uc010vvq.1_Silent_p.V413V|ELAC2_uc010vvr.1_Silent_p.V374V	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	414					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						GAACCATGGGCACACTGAGGG	0.562									Hereditary_Prostate_Cancer				21	54					1.28384e-07	1.50586e-07	1	0
MYO18A	399687	broad.mit.edu	37	17	27447762	27447762	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:27447762C>T	uc002hdt.1	-	7	1758	c.1600G>A	c.(1600-1602)GCT>ACT	p.A534T	MYO18A_uc010wbc.1_Missense_Mutation_p.A76T|MYO18A_uc002hds.2_Missense_Mutation_p.A76T|MYO18A_uc010csa.1_Missense_Mutation_p.A534T|MYO18A_uc002hdu.1_Missense_Mutation_p.A534T|MYO18A_uc010wbd.1_Missense_Mutation_p.A203T	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	534	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GTGTACAGAGCCTGCCACTTC	0.567													25	49					0	0	0	0
KRT28	162605	broad.mit.edu	37	17	38948796	38948796	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:38948796C>A	uc002hvh.1	-	8	1344	c.1278G>T	c.(1276-1278)AAG>AAT	p.K426N		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	426	Tail.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CAACCACTGTCTTTACCAGTG	0.348													10	25					3.86212e-05	4.21322e-05	1	0
LRRC37A4	55073	broad.mit.edu	37	17	43596429	43596429	+	5'Flank	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:43596429C>T	uc010wjq.1	-						uc010wjr.1_5'Flank|uc010wjs.1_5'Flank|uc010wjt.1_3'UTR					Homo sapiens cDNA FLJ10120 fis, clone HEMBA1002863.												0						TCACTTTTTGCCGGTTTTGGC	0.488													9	918					0	0	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46051295	46051295	+	Splice_Site	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:46051295A>G	uc002imr.2	+	4	269	c.185_splice	c.e4-2	p.Y62_splice	CDK5RAP3_uc010wlc.1_Splice_Site_p.Y82_splice|CDK5RAP3_uc002imq.1_Splice_Site|CDK5RAP3_uc002imu.2_Splice_Site|CDK5RAP3_uc002ims.2_Splice_Site|CDK5RAP3_uc002imv.2_Splice_Site|CDK5RAP3_uc002imw.2_Splice_Site|CDK5RAP3_uc002imx.2_Splice_Site	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3						brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						CTTGCTTTCTAGACATTCACT	0.443													35	115					0	0	0	0
SDK2	54549	broad.mit.edu	37	17	71390387	71390387	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:71390387G>A	uc010dfm.2	-	26	3669	c.3669C>T	c.(3667-3669)GTC>GTT	p.V1223V	SDK2_uc002jjt.3_Silent_p.V382V|SDK2_uc010dfn.2_Silent_p.V902V	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1223	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CAGCCTCGGGGACCTCGCTCC	0.652													5	19					0	0	0	0
MGAT5B	146664	broad.mit.edu	37	17	74901400	74901400	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:74901400G>T	uc002jti.2	+	6	976	c.873G>T	c.(871-873)CAG>CAT	p.Q291H	MGAT5B_uc002jth.2_Missense_Mutation_p.Q280H	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	280	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GGGCCACCCAGAGGGACCAGA	0.627													12	35					5.16669e-11	6.52634e-11	1	0
CIDEA	1149	broad.mit.edu	37	18	12262964	12262964	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:12262964G>T	uc002kqt.3	+	2	244	c.179G>T	c.(178-180)AGC>ATC	p.S60I	CIDEA_uc002kqu.3_Missense_Mutation_p.S94I|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	60	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						GAGCTCATCAGCAAGGTGCCC	0.642													8	26					0.00307968	0.00329062	1	0
MC2R	4158	broad.mit.edu	37	18	13884633	13884633	+	Missense_Mutation	SNP	C	G	G	rs147683219		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:13884633C>G	uc002ksp.1	-	2	1062	c.885G>C	c.(883-885)AGG>AGC	p.R295S		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	295	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TCTACCAGTACCTGCTGCAGA	0.478													18	57					0	0	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559713	44559713	+	Missense_Mutation	SNP	C	T	T	rs143582553		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:44559713C>T	uc002lcr.1	-	1	2276	c.1923G>A	c.(1921-1923)ATG>ATA	p.M641I	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	641	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGAAACAGATCATCTTTGCCT	0.537													68	80					0	0	0	0
DCC	1630	broad.mit.edu	37	18	50450075	50450075	+	Splice_Site	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:50450075A>G	uc002lfe.1	+	4	1285	c.698_splice	c.e4-2	p.D233_splice	DCC_uc010xdr.1_Splice_Site_p.D81_splice	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTCCCCTCATAGATCCAGGAC	0.343													14	18					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9062563	9062563	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9062563G>A	uc002mkp.2	-	3	25087	c.24883C>T	c.(24883-24885)CCT>TCT	p.P8295S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8297	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTCACAGGAAGAGAAGCG	0.512													22	50					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9086084	9086084	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9086084G>A	uc002mkp.2	-	1	5935	c.5731C>T	c.(5731-5733)CGA>TGA	p.R1911*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1911	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCAGGTCGGGGATGGATT	0.488													11	27					0	0	0	0
OR7G2	390882	broad.mit.edu	37	19	9213532	9213532	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9213532G>T	uc010xkk.1	-	1	451	c.451C>A	c.(451-453)CTT>ATT	p.L151I		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTGTATCTAAGGGGGTGACAA	0.498													15	28					1.05317e-09	1.28858e-09	1	0
ZNF563	147837	broad.mit.edu	37	19	12433432	12433432	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:12433432T>C	uc002mtp.2	-	2	335	c.97A>G	c.(97-99)ATG>GTG	p.M33V	ZNF563_uc002mtq.2_Missense_Mutation_p.M33V	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTTCTTGCATCACATATCTG	0.433													24	49					0	0	0	0
MEF2B	100271849	broad.mit.edu	37	19	19258514	19258514	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:19258514C>A	uc002nlm.2	-	4	500	c.386G>T	c.(385-387)CGG>CTG	p.R129L	MEF2B_uc002nln.2_Missense_Mutation_p.R176L|MEF2B_uc002nll.2_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R129L|MEF2B_uc002nlk.2_Missense_Mutation_p.R132L	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			TACATACAGCCGGGGTCGGGG	0.577													19	45					8.34094e-07	9.5325e-07	1	0
RYR1	6261	broad.mit.edu	37	19	38976617	38976617	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:38976617G>A	uc002oit.2	+	34	5452	c.5322G>A	c.(5320-5322)CCG>CCA	p.P1774P	RYR1_uc002oiu.2_Silent_p.P1774P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1774	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGAGGCCCCCGCATCATTTCT	0.692													8	81					0	0	0	0
MAP4K1	11184	broad.mit.edu	37	19	39100273	39100273	+	Silent	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:39100273G>C	uc002oix.1	-	13	1077	c.969C>G	c.(967-969)CGC>CGG	p.R323R	MAP4K1_uc002oiw.1_5'Flank|MAP4K1_uc002oiy.1_Silent_p.R323R|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	323					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAGAGCTGGAGCGGTGGGTGG	0.592													8	29					0	0	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062929	41062929	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:41062929G>T	uc002ony.2	+	26	5376	c.5290G>T	c.(5290-5292)GTG>TTG	p.V1764L	SPTBN4_uc002onx.2_Missense_Mutation_p.V1764L|SPTBN4_uc002onz.2_Missense_Mutation_p.V1764L|SPTBN4_uc010egx.2_Missense_Mutation_p.V507L|SPTBN4_uc002ooa.2_Missense_Mutation_p.V440L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1764	Spectrin 15.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGATGGCAGGTGCTGCAGGA	0.532													8	31					1.12685e-05	1.25117e-05	1	0
ZNF230	7773	broad.mit.edu	37	19	44515025	44515025	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:44515025G>A	uc002oyb.1	+	5	1085	c.834G>A	c.(832-834)AAG>AAA	p.K278K		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTGGGGAGAAGCCGTTCAAAT	0.423													21	94					0	0	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973549	46973549	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:46973549C>T	uc002peq.3	-	2	1050	c.744G>A	c.(742-744)AAG>AAA	p.K248K	PNMAL1_uc002per.3_Silent_p.K248K	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	248											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GCCTGGAGTTCTTCTTCTGCT	0.522													20	142					0	0	0	0
GLTSCR1	29998	broad.mit.edu	37	19	48202269	48202269	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:48202269C>T	uc002phh.3	+	13	3639	c.3445C>T	c.(3445-3447)CAG>TAG	p.Q1149*	GLTSCR1_uc002phi.3_Nonsense_Mutation_p.Q907*	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1149							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GAAACGCACCCAGGCCATGCT	0.632											OREG0025594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					0	0	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48601480	48601480	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:48601480C>A	uc002phx.2	-	6	882	c.484G>T	c.(484-486)GTG>TTG	p.V162L	PLA2G4C_uc002phw.2_Missense_Mutation_p.V97L|PLA2G4C_uc010elr.2_Missense_Mutation_p.V162L|PLA2G4C_uc010xzd.1_Missense_Mutation_p.V172L|PLA2G4C_uc002phy.3_Missense_Mutation_p.V162L	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	162	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CCTTCTTCCACGGGCTTCTTC	0.527													27	82					1.75199e-13	2.25876e-13	1	0
PRR12	57479	broad.mit.edu	37	19	50098459	50098459	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:50098459C>T	uc002poo.3	+	4	867	c.867C>T	c.(865-867)ATC>ATT	p.I289I		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACACGGTCATCAAGCACTACC	0.697													5	12					0	0	0	0
ZNF665	79788	broad.mit.edu	37	19	53668172	53668172	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:53668172C>A	uc010eqm.1	-	4	1671	c.1571G>T	c.(1570-1572)AGT>ATT	p.S524I		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	459	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGAATGAACACTAAAGGCTTT	0.393													47	121					1.6237e-14	2.11964e-14	1	0
MBOAT7	79143	broad.mit.edu	37	19	54677883	54677883	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:54677883T>G	uc002qdq.2	-	9	1540	c.1274A>C	c.(1273-1275)TAC>TCC	p.Y425S	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.Y109S|MBOAT7_uc010yem.1_Missense_Mutation_p.Y407S|MBOAT7_uc002qdr.2_Missense_Mutation_p.Y425S|MBOAT7_uc002qds.2_Missense_Mutation_p.Y352S|MBOAT7_uc010yen.1_Missense_Mutation_p.Y352S	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	425					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGAGGCCCAGTACCGAAGGGT	0.637													18	103					0	0	0	0
U2AF2	11338	broad.mit.edu	37	19	56171880	56171880	+	Splice_Site	SNP	A	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:56171880A>C	uc002qlu.2	+	4	1286	c.231_splice	c.e4-2	p.I77_splice	U2AF2_uc002qlt.2_Splice_Site_p.I77_splice	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CACCTCCCCCAGTCGTTCCCC	0.637													5	11					0	0	0	0
VSNL1	7447	broad.mit.edu	37	2	17836566	17836566	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:17836566A>T	uc002rcm.2	+	4	865	c.481A>T	c.(481-483)AAC>TAC	p.N161Y		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	161	3 (Potential).|EF-hand 4.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GATGGATAAGAACAAAGATGA	0.428													26	26					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27550056	27550056	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:27550056C>G	uc002rjv.1	-	19	2868	c.2505G>C	c.(2503-2505)GAG>GAC	p.E835D	MPV17_uc002rjt.2_5'Flank|GTF3C2_uc010eyy.1_Missense_Mutation_p.E290D|GTF3C2_uc002rju.1_Missense_Mutation_p.E846D|GTF3C2_uc002rjw.1_Missense_Mutation_p.E835D	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	835	WD 4.					transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATGAATAGCCTCCAGCTGCA	0.542													6	42					0	0	0	0
LHCGR	3973	broad.mit.edu	37	2	48936097	48936097	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:48936097G>T	uc002rwu.3	-	8	740	c.670C>A	c.(670-672)CCG>ACG	p.P224T	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	224	Extracellular (Potential).|LRR 6.				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AAGGTTTTCGGCCCTGTGGCC	0.542									Familial_Male-Limited_Precocious_Puberty				32	149					6.02846e-25	8.43443e-25	1	0
NRXN1	9378	broad.mit.edu	37	2	51255050	51255050	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:51255050C>A	uc010fbq.2	-	2	1839	c.362G>T	c.(361-363)CGC>CTC	p.R121L	NRXN1_uc002rxe.3_Missense_Mutation_p.R121L|NRXN1_uc002rxd.1_Missense_Mutation_p.R121L	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	184	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGGAACTGGCGGCGGATGCG	0.647													22	33					2.37509e-13	3.037e-13	1	0
DYSF	8291	broad.mit.edu	37	2	71778282	71778282	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:71778282G>A	uc002sie.2	+	18	2010	c.1634G>A	c.(1633-1635)GGC>GAC	p.G545D	DYSF_uc010feg.2_Missense_Mutation_p.G576D|DYSF_uc010feh.2_Missense_Mutation_p.G531D|DYSF_uc002sig.3_Missense_Mutation_p.G531D|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.G545D|DYSF_uc010fef.2_Missense_Mutation_p.G562D|DYSF_uc010fei.2_Missense_Mutation_p.G562D|DYSF_uc010fek.2_Missense_Mutation_p.G563D|DYSF_uc010fej.2_Missense_Mutation_p.G532D|DYSF_uc010fel.2_Missense_Mutation_p.G532D|DYSF_uc010feo.2_Missense_Mutation_p.G577D|DYSF_uc010fem.2_Missense_Mutation_p.G546D|DYSF_uc010fen.2_Missense_Mutation_p.G563D|DYSF_uc002sif.2_Missense_Mutation_p.G546D	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	545	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTCAACACAGGCAAGGTAAGC	0.627													38	53					0	0	0	0
PTCD3	55037	broad.mit.edu	37	2	86352147	86352147	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:86352147C>T	uc002sqw.2	+	10	812	c.746C>T	c.(745-747)TCT>TTT	p.S249F	PTCD3_uc010ytc.1_RNA|PTCD3_uc002sqx.1_5'UTR	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	249						mitochondrion	protein binding			ovary(1)	1						AGAATCTTTTCTCTAATGCCA	0.318													5	35					0	0	0	0
SMYD1	150572	broad.mit.edu	37	2	88407935	88407935	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:88407935G>A	uc002ssr.2	+	9	1193	c.1191G>A	c.(1189-1191)ATG>ATA	p.M397I	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.M93I	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TGGCCGTGATGCGGGCAGGGC	0.542													29	36					0	0	0	0
BUB1	699	broad.mit.edu	37	2	111416240	111416240	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:111416240C>T	uc002tgc.2	-	12	1468	c.1356G>A	c.(1354-1356)ACG>ACA	p.T452T	BUB1_uc010yxh.1_Silent_p.T432T|BUB1_uc010fkb.2_Silent_p.T452T	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	452					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		CTTTGGATGGCGTTGCCTGAA	0.433													17	34					0	0	0	0
YSK4	80122	broad.mit.edu	37	2	135743820	135743820	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:135743820A>T	uc002tue.1	-	7	2653	c.2622T>A	c.(2620-2622)AAT>AAA	p.N874K	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.N761K|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.N602K|YSK4_uc002tui.3_Missense_Mutation_p.N891K	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	874							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAGATGCTGTATTCTGCTTTT	0.378													22	42					0	0	0	0
CACNB4	785	broad.mit.edu	37	2	152698521	152698521	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:152698521G>A	uc002tya.2	-	13	1266	c.1198C>T	c.(1198-1200)CGT>TGT	p.R400C	CACNB4_uc002txy.2_Missense_Mutation_p.R366C|CACNB4_uc002txz.2_Missense_Mutation_p.R382C|CACNB4_uc010fnz.2_Intron	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	400					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	TGGGTGGCACGCCAGTACGCC	0.493													25	63					0	0	0	0
SCN2A	6326	broad.mit.edu	37	2	166172118	166172118	+	Silent	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:166172118A>G	uc002udc.2	+	11	1811	c.1521A>G	c.(1519-1521)AAA>AAG	p.K507K	SCN2A_uc002udd.2_Silent_p.K507K|SCN2A_uc002ude.2_Silent_p.K507K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	507					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	gaagaaagaaaaagaaacaga	0.303													14	29					0	0	0	0
ABCB11	8647	broad.mit.edu	37	2	169787239	169787239	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:169787239C>T	uc002ueo.1	-	25	3473	c.3347G>A	c.(3346-3348)GGA>GAA	p.G1116E	ABCB11_uc010zda.1_Missense_Mutation_p.G558E|ABCB11_uc010zdb.1_Missense_Mutation_p.G592E	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1116	Cytoplasmic (Potential).|ATP 2 (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TTTGCCACATCCACTGCTCCC	0.463													6	19					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179650467	179650467	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:179650467G>A	uc010zfg.1	-	15	2597	c.2373C>T	c.(2371-2373)ATC>ATT	p.I791I	TTN_uc010zfh.1_Silent_p.I745I|TTN_uc010zfi.1_Silent_p.I745I|TTN_uc010zfj.1_Silent_p.I745I|TTN_uc002unb.2_Silent_p.I791I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	791							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGTTTTCTTGATCTGCATTG	0.413													12	66					0	0	0	0
PGAP1	80055	broad.mit.edu	37	2	197737751	197737751	+	Splice_Site	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:197737751C>A	uc002utw.2	-	17	1667	c.1553_splice	c.e17-1	p.E518_splice	PGAP1_uc002utx.2_Splice_Site_p.E344_splice|PGAP1_uc002uty.1_Splice_Site_p.E518_splice	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						GTTATTTCTTCTGTTAAAACA	0.249													3	11					0.004672	0.00497496	1	0
XRCC5	7520	broad.mit.edu	37	2	216986930	216986930	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:216986930A>G	uc002vfy.2	+	6	777	c.637A>G	c.(637-639)ATA>GTA	p.I213V	XRCC5_uc002vfz.2_Missense_Mutation_p.I99V	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	213					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AATGGTGATGATATCTTTAGA	0.383								Direct_reversal_of_damage|NHEJ					14	49					0	0	0	0
SLC4A3	6508	broad.mit.edu	37	2	220493179	220493179	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:220493179A>G	uc002vmp.3	+	3	373	c.104A>G	c.(103-105)GAC>GGC	p.D35G	SLC4A3_uc002vmn.2_Missense_Mutation_p.D35G|SLC4A3_uc002vmo.3_Missense_Mutation_p.D35G|SLC4A3_uc010fwm.2_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	35	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGGAGGAGGACGATGACTTG	0.657													5	19					0	0	0	0
UGT1A5	54579	broad.mit.edu	37	2	234680964	234680964	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:234680964C>T	uc002vuw.2	+	5	1364	c.1364C>T	c.(1363-1365)CCG>CTG	p.P455L	UGT1A8_uc002vup.2_Missense_Mutation_p.P451L|UGT1A10_uc002vur.2_Missense_Mutation_p.P451L|UGT1A9_uc002vus.2_Missense_Mutation_p.P451L|UGT1A7_uc002vut.2_Missense_Mutation_p.P451L|UGT1A6_uc002vuu.2_Missense_Mutation_p.P186L|UGT1A6_uc002vuv.3_Missense_Mutation_p.P453L|UGT1A4_uc002vux.2_Missense_Mutation_p.P455L|UGT1A3_uc002vuy.2_Missense_Mutation_p.P455L|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Missense_Mutation_p.P454L	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	455					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCGGTGGAGCCGCTGGACCTG	0.587													15	84					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8741079	8741079	+	Silent	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:8741079A>G	uc002wnb.2	+	25	2685	c.2682A>G	c.(2680-2682)ACA>ACG	p.T894T	PLCB1_uc010zrb.1_Silent_p.T793T|PLCB1_uc002wna.2_Silent_p.T894T|PLCB1_uc002wnc.1_Silent_p.T793T|PLCB1_uc002wnd.1_Silent_p.T471T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	894					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGCCAAAACAGAAGATCTTA	0.358													5	14					0	0	0	0
CHD6	84181	broad.mit.edu	37	20	40033381	40033381	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:40033381G>A	uc002xka.1	-	37	8178	c.8000C>T	c.(7999-8001)TCC>TTC	p.S2667F	CHD6_uc002xjz.1_Missense_Mutation_p.S204F	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2667					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CTCTGGGTGGGAGTTGGGGTT	0.587													35	101					0	0	0	0
PTPN1	5770	broad.mit.edu	37	20	49195149	49195149	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:49195149G>A	uc002xvl.2	+	6	859	c.685G>A	c.(685-687)GAT>AAT	p.D229N	PTPN1_uc010zys.1_Missense_Mutation_p.D156N	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	229	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CTGTCTGGCTGATACCTGCCT	0.587													7	44					0	0	0	0
CASS4	57091	broad.mit.edu	37	20	55026880	55026880	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:55026880G>T	uc002xxp.2	+	6	873	c.648G>T	c.(646-648)CAG>CAT	p.Q216H	CASS4_uc002xxq.3_Missense_Mutation_p.Q216H|CASS4_uc002xxr.2_Missense_Mutation_p.Q216H|CASS4_uc010zze.1_Missense_Mutation_p.Q162H|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	216					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CACAGGGGCAGGGTGTTCCCC	0.502													18	48					1.00905e-13	1.30632e-13	1	0
SAMSN1	64092	broad.mit.edu	37	21	15870786	15870786	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:15870786G>A	uc002yju.1	-	7	978	c.896C>T	c.(895-897)GCT>GTT	p.A299V	SAMSN1_uc010gky.1_Missense_Mutation_p.A131V|SAMSN1_uc002yjv.1_Missense_Mutation_p.A367V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	299	SAM.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		GAAGTTTTCAGCAGCTGATAG	0.338													12	33					0	0	0	0
TIAM1	7074	broad.mit.edu	37	21	32582412	32582412	+	Silent	SNP	C	G	G	rs28520154		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:32582412C>G	uc002yow.1	-	12	2809	c.2337G>C	c.(2335-2337)ACG>ACC	p.T779T	TIAM1_uc011adk.1_Silent_p.T779T|TIAM1_uc011adl.1_Silent_p.T754T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	779	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCGGACGACCGTCAGGGCAG	0.547													12	40					0	0	0	0
TIAM1	7074	broad.mit.edu	37	21	32638554	32638554	+	Silent	SNP	T	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:32638554T>G	uc002yow.1	-	5	1207	c.735A>C	c.(733-735)GCA>GCC	p.A245A	TIAM1_uc011adk.1_Silent_p.A245A|TIAM1_uc011adl.1_Silent_p.A245A|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	245					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCCCCCGTTTGCTGTCACTC	0.547													25	80					0	0	0	0
TRPM2	7226	broad.mit.edu	37	21	45815335	45815335	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:45815335C>A	uc002zet.1	+	13	2046	c.1833C>A	c.(1831-1833)TCC>TCA	p.S611S	TRPM2_uc002zeu.1_Silent_p.S611S|TRPM2_uc002zew.1_Silent_p.S611S|TRPM2_uc010gpt.1_Silent_p.S611S|TRPM2_uc002zex.1_Silent_p.S397S|TRPM2_uc002zey.1_Silent_p.S124S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	611	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACAAGCGTTCCTCAGGCCATG	0.502													11	139					4.3838e-07	5.08456e-07	1	0
GNAZ	2781	broad.mit.edu	37	22	23438557	23438557	+	Silent	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr22:23438557T>C	uc002zwu.1	+	2	1212	c.675T>C	c.(673-675)TGT>TGC	p.C225C	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	225						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TCATCTTCTGTGTGGAGCTCA	0.567													44	205					0	0	0	0
SEC14L4	284904	broad.mit.edu	37	22	30887558	30887558	+	Splice_Site	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr22:30887558A>G	uc003aid.2	-	11	1181	c.1081_splice	c.e11+1	p.Y361_splice	SEC14L4_uc011akz.1_Splice_Site_p.*361_splice|SEC14L4_uc003aie.2_Splice_Site_p.Y346_splice|SEC14L4_uc003aif.2_Splice_Site_p.Y307_splice	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a							integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	CGCAGCTCTTACAGACGCCAG	0.602													11	62					0	0	0	0
IL5RA	3568	broad.mit.edu	37	3	3146617	3146617	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:3146617G>T	uc011ask.1	-	4	696	c.52C>A	c.(52-54)CTG>ATG	p.L18M	IL5RA_uc010hbq.2_Missense_Mutation_p.L18M|IL5RA_uc010hbr.2_Missense_Mutation_p.L18M|IL5RA_uc010hbs.2_Missense_Mutation_p.L18M|IL5RA_uc011asl.1_Missense_Mutation_p.L18M|IL5RA_uc011asm.1_Missense_Mutation_p.L18M|IL5RA_uc010hbt.2_Missense_Mutation_p.L18M|IL5RA_uc011asn.1_Missense_Mutation_p.L18M|IL5RA_uc010hbu.2_Missense_Mutation_p.L18M	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	18					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		TCAGCTTGCAGTATCTCAGTG	0.333													7	12					5.68852e-11	7.15653e-11	1	0
FLNB	2317	broad.mit.edu	37	3	58109357	58109357	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:58109357G>A	uc003djj.2	+	21	3829	c.3664G>A	c.(3664-3666)GTG>ATG	p.V1222M	FLNB_uc010hne.2_Missense_Mutation_p.V1222M|FLNB_uc003djk.2_Missense_Mutation_p.V1222M|FLNB_uc010hnf.2_Missense_Mutation_p.V1222M|FLNB_uc003djl.2_Missense_Mutation_p.V1053M|FLNB_uc003djm.2_Missense_Mutation_p.V1053M	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1222	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCGGGTCAAGGTGGAGCCCGC	0.517													16	33					0	0	0	0
FOXP1	27086	broad.mit.edu	37	3	71019957	71019957	+	Splice_Site	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:71019957C>T	uc003dol.2	-	15	1976	c.1653_splice	c.e15-1	p.G551_splice	FOXP1_uc003dom.2_Splice_Site_p.G475_splice|FOXP1_uc003don.2_Splice_Site|FOXP1_uc003doo.2_Splice_Site_p.G550_splice|FOXP1_uc003dop.2_Splice_Site_p.G551_splice|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Splice_Site_p.G451_splice|FOXP1_uc003doj.2_Splice_Site_p.G451_splice|FOXP1_uc003dok.2_Splice_Site_p.G364_splice|FOXP1_uc003dor.1_3'UTR	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1						cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GGAAGGGTTACTGTGTAAGAA	0.433			T	PAX5	ALL								24	40					0	0	0	0
MYH15	22989	broad.mit.edu	37	3	108163738	108163738	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:108163738C>A	uc003dxa.1	-	23	2521	c.2464G>T	c.(2464-2466)GCA>TCA	p.A822S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	822	IQ.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AAAATAAGTGCATCCCTAAAT	0.373													18	28					1.2644e-06	1.43976e-06	1	0
DPPA2	151871	broad.mit.edu	37	3	109031513	109031513	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:109031513A>T	uc003dxo.2	-	3	307	c.60T>A	c.(58-60)GAT>GAA	p.D20E		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	20						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CACTTTCCTCATCATCTACTT	0.408													8	82					0	0	0	0
KTELC1	56983	broad.mit.edu	37	3	119199009	119199009	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:119199009G>C	uc003ecm.2	+	5	652	c.568G>C	c.(568-570)GAT>CAT	p.D190H	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Missense_Mutation_p.D31H	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	190						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		CTTCAGAGAAGATCTGGTAAG	0.383													10	34					0	0	0	0
KTELC1	56983	broad.mit.edu	37	3	119210421	119210421	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:119210421G>C	uc003ecm.2	+	10	1106	c.1022G>C	c.(1021-1023)AGG>ACG	p.R341T	KTELC1_uc011bja.1_Missense_Mutation_p.R182T	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	341						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		ATTGCTGAAAGGTGAGTTCTG	0.343													3	15					0	0	0	0
NPHP3	27031	broad.mit.edu	37	3	132435712	132435712	+	Missense_Mutation	SNP	C	T	T	rs147399998		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:132435712C>T	uc003epe.1	-	4	789	c.712G>A	c.(712-714)GGA>AGA	p.G238R	NPHP3_uc003epf.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	238					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GGTTCACTTCCCAAGGCTCCG	0.448													6	38					0	0	0	0
ATR	545	broad.mit.edu	37	3	142242944	142242944	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:142242944G>A	uc003eux.3	-	22	4165	c.4043C>T	c.(4042-4044)TCT>TTT	p.S1348F		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1348	HEAT 2.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CCGAGCTTGAGAGTTTGCATC	0.413								Other_conserved_DNA_damage_response_genes					7	63					0	0	0	0
SGEF	26084	broad.mit.edu	37	3	153840415	153840415	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:153840415G>A	uc011bog.1	+	2	845	c.634G>A	c.(634-636)GAA>AAA	p.E212K	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.E212K	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	212					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAGTTCTTCGGAACAAAAACT	0.587													59	50					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168838941	168838941	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:168838941G>T	uc003ffi.3	-	6	740	c.471C>A	c.(469-471)GCC>GCA	p.A157A	MECOM_uc010hwk.1_Silent_p.A180A|MECOM_uc003ffj.3_Silent_p.A222A|MECOM_uc011bpi.1_Silent_p.A158A|MECOM_uc003ffn.3_Silent_p.A157A|MECOM_uc003ffk.2_Silent_p.A157A|MECOM_uc003ffl.2_Silent_p.A317A|MECOM_uc011bpj.1_Silent_p.A345A|MECOM_uc011bpk.1_Silent_p.A147A|MECOM_uc010hwn.2_Silent_p.A345A	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	157	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGGGCCCGGGCACCGACAT	0.512													49	47					3.21987e-24	4.48482e-24	1	0
OPA1	4976	broad.mit.edu	37	3	193332569	193332569	+	Silent	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:193332569A>T	uc003ftm.2	+	2	324	c.90A>T	c.(88-90)CTA>CTT	p.L30L	OPA1_uc003ftg.2_Silent_p.L30L|OPA1_uc003fth.2_Silent_p.L30L|OPA1_uc003fti.2_Silent_p.L30L|OPA1_uc003ftj.2_Silent_p.L30L|OPA1_uc003ftk.2_Silent_p.L30L|OPA1_uc003ftl.2_Silent_p.L30L|OPA1_uc003ftn.2_Silent_p.L30L	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	30					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		GTTTACCACTACAAAAACTAC	0.318													47	46					0	0	0	0
ATP8A1	10396	broad.mit.edu	37	4	42576696	42576696	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:42576696C>G	uc003gwr.2	-	14	1467	c.1235G>C	c.(1234-1236)GGT>GCT	p.G412A	ATP8A1_uc003gws.2_Missense_Mutation_p.G412A|ATP8A1_uc011byz.1_Missense_Mutation_p.G412A	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	412	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TGTCAGAGTACCAGTTTTGTC	0.323													4	24					0	0	0	0
UBA6	55236	broad.mit.edu	37	4	68490770	68490770	+	Missense_Mutation	SNP	C	T	T	rs140996878		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:68490770C>T	uc003hdg.3	-	29	2706	c.2654G>A	c.(2653-2655)CGC>CAC	p.R885H		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	885					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						ACCAGCTATGCGCTTTGTTTT	0.373													8	45					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72420881	72420881	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:72420881G>C	uc003hfy.2	+	21	2836	c.2719G>C	c.(2719-2721)GGT>CGT	p.G907R	SLC4A4_uc010iic.2_Missense_Mutation_p.G907R|SLC4A4_uc010iib.2_Missense_Mutation_p.G823R|SLC4A4_uc003hfz.2_Missense_Mutation_p.G907R|SLC4A4_uc003hgc.3_Missense_Mutation_p.G863R|SLC4A4_uc010iid.2_Missense_Mutation_p.G111R	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	907	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGTACTCTATGGTGTGTTCCT	0.328													28	210					0	0	0	0
CXCL1	2919	broad.mit.edu	37	4	74735491	74735491	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:74735491G>A	uc003hhh.1	+	2	285	c.206G>A	c.(205-207)TGC>TAC	p.C69Y		NM_001511	NP_001502	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1	69					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GGACCCCACTGCGCCCAAACC	0.652													65	101					0	0	0	0
FGF5	2250	broad.mit.edu	37	4	81196135	81196135	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:81196135C>G	uc003hmd.2	+	2	665	c.428C>G	c.(427-429)GCG>GGG	p.A143G	FGF5_uc003hme.2_Intron	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	143					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						AAATTTTTAGCGATGTCAAAA	0.318													6	14					0	0	0	0
HERC6	55008	broad.mit.edu	37	4	89326088	89326088	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:89326088T>A	uc011cdi.1	+	9	1336	c.1153T>A	c.(1153-1155)TCC>ACC	p.S385T	HERC6_uc011cdj.1_Missense_Mutation_p.S385T|HERC6_uc011cdk.1_Intron|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	385					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		AATTAGCCAGTCCATGGCAGA	0.428													21	45					0	0	0	0
SDHAP3	728609	broad.mit.edu	37	5	1593386	1593386	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:1593386A>C	uc010itg.1	-	2	151	c.74T>G	c.(73-75)GTG>GGG	p.V25G	SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA clone IMAGE:40127561.												0						CTGGCCATTCACGTGCCTCAG	0.597													3	33					0	0	0	0
MTRR	4552	broad.mit.edu	37	5	7873625	7873625	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:7873625G>T	uc003jed.2	+	3	380	c.350G>T	c.(349-351)CGG>CTG	p.R117L	MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Missense_Mutation_p.R90L|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	117	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GCTCACCTGCGGTATGGGTTA	0.443													11	42					2.27111e-07	2.65388e-07	1	0
ANKRD34B	340120	broad.mit.edu	37	5	79855683	79855683	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:79855683C>T	uc010jam.2	-	4	506	c.156G>A	c.(154-156)AAG>AAA	p.K52K	ANKRD34B_uc003kgw.2_Silent_p.K52K|ANKRD34B_uc010jan.2_Silent_p.K52K	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	52	ANK 2.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		CATGTTTGGTCTTACAAGCGA	0.463													23	143					0	0	0	0
MEF2C	4208	broad.mit.edu	37	5	88047801	88047801	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:88047801A>C	uc003kjj.2	-	5	1135	c.462T>G	c.(460-462)AGT>AGG	p.S154R	MEF2C_uc003kji.2_Missense_Mutation_p.S154R|MEF2C_uc003kjk.2_Missense_Mutation_p.S154R|MEF2C_uc003kjm.2_Missense_Mutation_p.S152R|MEF2C_uc003kjl.2_Missense_Mutation_p.S172R	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	154	Ser-rich.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TGTACACCAAACTGTTGTGGC	0.493										HNSCC(66;0.2)			13	89					0	0	0	0
MCTP1	79772	broad.mit.edu	37	5	94288963	94288963	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:94288963C>G	uc003kkx.2	-	3	941	c.941G>C	c.(940-942)TGT>TCT	p.C314S	MCTP1_uc003kkv.2_Missense_Mutation_p.C93S|MCTP1_uc003kkw.2_Missense_Mutation_p.C93S|MCTP1_uc003kkz.2_5'UTR	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	314	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AACCAGAATACAAGCTTTTTC	0.368													6	21					0	0	0	0
RFESD	317671	broad.mit.edu	37	5	94989858	94989858	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:94989858A>T	uc003klf.2	+	3	1485	c.93A>T	c.(91-93)AGA>AGT	p.R31S	RFESD_uc003klg.2_Missense_Mutation_p.R84S|RFESD_uc011cun.1_Missense_Mutation_p.R84S|SPATA9_uc010jbh.1_Intron|SPATA9_uc003klh.1_Intron|SPATA9_uc003kli.1_Intron	NM_173362	NP_775498	Q8TAC1	RFESD_HUMAN	Rieske (Fe-S) domain containing isoform 2	31	Rieske 2.|Rieske 1.						2 iron, 2 sulfur cluster binding|metal ion binding|oxidoreductase activity				0		all_cancers(142;0.000215)|all_epithelial(76;7.43e-07)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)|Colorectal(57;0.162)		all cancers(79;5.94e-17)		AATCTGAAAGAATGACAGCTG	0.383													8	34					0	0	0	0
PCDHB9	56127	broad.mit.edu	37	5	140567435	140567435	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140567435A>C	uc003liw.1	+	1	543	c.543A>C	c.(541-543)AAA>AAC	p.K181N		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	181	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCATATTAAAATTAGTGGCA	0.448													6	143					0	0	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741362	140741362	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140741362G>C	uc003ljs.1	+	1	1660	c.1660G>C	c.(1660-1662)GAC>CAC	p.D554H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.D554H|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	554	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTAGTGGGCGACCTCAATGA	0.687													41	58					0	0	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140866933	140866933	+	Silent	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140866933T>C	uc003lky.1	+	1	2193	c.2193T>C	c.(2191-2193)TGT>TGC	p.C731C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Silent_p.C731C|PCDHGC5_uc011dbc.1_5'Flank|PCDHGC5_uc003lla.1_5'Flank	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	731	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCACCTGTGCCTGTCTCA	0.537													8	61					0	0	0	0
ARAP3	64411	broad.mit.edu	37	5	141033932	141033932	+	Missense_Mutation	SNP	A	G	G	rs142227089		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:141033932A>G	uc003llm.2	-	33	4298	c.4220T>C	c.(4219-4221)GTG>GCG	p.V1407A	ARAP3_uc003lll.2_Missense_Mutation_p.V358A|ARAP3_uc011dbe.1_Missense_Mutation_p.V1056A|ARAP3_uc003lln.2_Missense_Mutation_p.V1238A	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1407					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TTCCTCATACACTGGCTCCTC	0.582													10	91					0	0	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948568	2948568	+	Missense_Mutation	SNP	G	T	T	rs145397970	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:2948568G>T	uc003muk.2	-	6	3090	c.1095C>A	c.(1093-1095)AAC>AAA	p.N365K	SERPINB6_uc003mui.2_Missense_Mutation_p.N248K|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.N365K|SERPINB6_uc003mum.2_Missense_Mutation_p.N365K|SERPINB6_uc003mun.2_Missense_Mutation_p.N365K|SERPINB6_uc003muo.2_Missense_Mutation_p.N365K	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	365					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGAGAATCCCGTTGGTCTTGC	0.602													34	36					5.97227e-30	8.46976e-30	1	0
HIST1H3D	8351	broad.mit.edu	37	6	26197234	26197234	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:26197234T>A	uc003ngv.2	-	2	642	c.245A>T	c.(244-246)GAT>GTT	p.D82V	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	82					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				AAAACGCAGATCAGTCTTGAA	0.607													18	88					0	0	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271403	26271403	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:26271403G>A	uc003nhi.2	-	1	210	c.210C>T	c.(208-210)CGC>CGT	p.R70R	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	70				R -> C (in Ref. 13; AAH67493).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						CTCGCACCAGGCGTTGGAAAG	0.602													12	138					0	0	0	0
OR10C1	442194	broad.mit.edu	37	6	29407954	29407954	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:29407954C>A	uc011dlp.1	+	1	162	c.162C>A	c.(160-162)CTC>CTA	p.L54L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGCTGCCCTCCAGTCCCCTA	0.562													54	92					5.57489e-27	7.83498e-27	1	0
VARS	7407	broad.mit.edu	37	6	31752467	31752467	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:31752467C>A	uc003nxe.2	-	11	1795	c.1372G>T	c.(1372-1374)GCC>TCC	p.A458S	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	458					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CGGACAAAGGCCTCTGTCACA	0.592													24	53					4.47668e-21	6.07271e-21	1	0
DOM3Z	1797	broad.mit.edu	37	6	31938542	31938542	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:31938542G>A	uc003nyo.1	-	3	1187	c.653C>T	c.(652-654)TCT>TTT	p.S218F	DOM3Z_uc003nyp.1_Missense_Mutation_p.S218F|DOM3Z_uc003nyq.1_Intron|DOM3Z_uc003nyr.1_Missense_Mutation_p.S218F|DOM3Z_uc003nys.1_3'UTR|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	218							identical protein binding|metal ion binding|nucleotide binding				0						GCGTAGCACAGAGCAGAAGGC	0.622													6	42					0	0	0	0
PM20D2	135293	broad.mit.edu	37	6	89862895	89862895	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:89862895A>T	uc003pmz.2	+	3	843	c.748A>T	c.(748-750)AGA>TGA	p.R250*		NM_001010853	NP_001010853	Q8IYS1	P20D2_HUMAN	aminoacylase 1-like 2	250							hydrolase activity				0		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)		ACCAACCTGGAGAGTTCATGG	0.348													18	29					0	0	0	0
EPHA7	2045	broad.mit.edu	37	6	94068039	94068039	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:94068039G>T	uc003poe.2	-	4	1164	c.923C>A	c.(922-924)TCC>TAC	p.S308Y	EPHA7_uc003pof.2_Missense_Mutation_p.S308Y|EPHA7_uc011eac.1_Missense_Mutation_p.S308Y	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	308	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TTCACATCTGGAGGAGCCTTC	0.463													43	41					3.7052e-28	5.23087e-28	1	0
WASF1	8936	broad.mit.edu	37	6	110421760	110421760	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:110421760C>T	uc003ptv.1	-	11	2482	c.1645G>A	c.(1645-1647)GAT>AAT	p.D549N	WASF1_uc003ptw.1_Missense_Mutation_p.D549N|WASF1_uc003ptx.1_Missense_Mutation_p.D549N|WASF1_uc003pty.1_Missense_Mutation_p.D549N	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	549					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		AATTCTGAATCATCTTCCGAA	0.393													11	22					0	0	0	0
PTPRK	5796	broad.mit.edu	37	6	128304088	128304088	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:128304088G>A	uc003qbk.2	-	24	3789	c.3422C>T	c.(3421-3423)GCC>GTC	p.A1141V	PTPRK_uc003qbj.2_Missense_Mutation_p.A1142V|PTPRK_uc010kfc.2_Missense_Mutation_p.A1148V|PTPRK_uc011ebu.1_Missense_Mutation_p.A1164V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1141	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACATAAGCAGGCTTCTAAAAT	0.333													8	68					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146720389	146720389	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:146720389T>A	uc010khw.1	+	8	2684	c.2214T>A	c.(2212-2214)AGT>AGA	p.S738R	GRM1_uc010khv.1_Missense_Mutation_p.S738R|GRM1_uc003qll.2_Missense_Mutation_p.S738R|GRM1_uc011edz.1_Missense_Mutation_p.S738R|GRM1_uc011eea.1_Missense_Mutation_p.S738R	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	738	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCTACCCAAGTATCAAGGAAG	0.493													46	70					0	0	0	0
LRP11	84918	broad.mit.edu	37	6	150184555	150184555	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:150184555G>A	uc003qng.2	-	1	926	c.602C>T	c.(601-603)TCG>TTG	p.S201L	uc003qni.1_5'Flank|LRP11_uc003qnh.1_Missense_Mutation_p.S201L	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	201	Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CTgccggggcgaggcgcgcgc	0.502													8	15					0	0	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151239718	151239718	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:151239718G>A	uc003qob.2	+	9	1166	c.898G>A	c.(898-900)GTT>ATT	p.V300I	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.V301I|MTHFD1L_uc003qoc.2_Missense_Mutation_p.V248I	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	300	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TACAGGGAAGGTTGGGTGTGG	0.413													28	42					0	0	0	0
C6orf118	168090	broad.mit.edu	37	6	165715503	165715503	+	Missense_Mutation	SNP	G	T	T	rs149637046	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:165715503G>T	uc003qum.3	-	2	344	c.308C>A	c.(307-309)GCG>GAG	p.A103E	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	103											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CTTCATCCTCGCCACCTTCCC	0.682													43	49					6.2361e-21	8.42279e-21	1	0
PDE10A	10846	broad.mit.edu	37	6	165848755	165848755	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:165848755C>A	uc003qun.2	-	7	718	c.477G>T	c.(475-477)AGG>AGT	p.R159S	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R89S|PDE10A_uc003quo.2_Missense_Mutation_p.R169S	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	159	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GCAGTGTTTTCCTGGACTTGG	0.458													11	60					0.000151284	0.000163892	1	0
TCP10L2	401285	broad.mit.edu	37	6	167595389	167595389	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:167595389G>A	uc010kkp.2	+	8	1178	c.1047G>A	c.(1045-1047)CAG>CAA	p.Q349Q		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	349											0						CCTCCAGACAGGACATGGGGC	0.517													18	8					0	0	0	0
NXPH1	30010	broad.mit.edu	37	7	8791022	8791022	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:8791022G>T	uc003srv.2	+	3	1350	c.439G>T	c.(439-441)GGG>TGG	p.G147W	NXPH1_uc011jxh.1_Missense_Mutation_p.G30W	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	147	III.					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TCATGGCAATGGGACATTTAG	0.393													15	50					2.32078e-09	2.81745e-09	1	0
SP4	6671	broad.mit.edu	37	7	21469118	21469118	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:21469118C>T	uc003sva.2	+	3	516	c.335C>T	c.(334-336)TCA>TTA	p.S112L	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	112					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						CCTCCTGCTTCAAAAGAGAAT	0.438													17	56					0	0	0	0
GPR141	353345	broad.mit.edu	37	7	37780667	37780667	+	Missense_Mutation	SNP	G	T	T	rs145445554	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:37780667G>T	uc003tfm.1	+	1	672	c.672G>T	c.(670-672)CAG>CAT	p.Q224H	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	224	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TCTGGGCTCAGCTGAAAAACC	0.438													43	110					2.35958e-20	3.17323e-20	1	0
COBL	23242	broad.mit.edu	37	7	51097136	51097136	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:51097136C>G	uc003tpr.3	-	10	1842	c.1657G>C	c.(1657-1659)GAT>CAT	p.D553H	COBL_uc003tps.2_Missense_Mutation_p.D610H|COBL_uc011kcl.1_Missense_Mutation_p.D553H|COBL_uc003tpp.3_Missense_Mutation_p.D339H|COBL_uc003tpq.3_Missense_Mutation_p.D494H|COBL_uc003tpo.3_Missense_Mutation_p.D95H	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	553										skin(3)|ovary(2)	5	Glioma(55;0.08)					AACCCCGAATCCACAGGATCA	0.527													22	55					0	0	0	0
ZNF679	168417	broad.mit.edu	37	7	63721218	63721218	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:63721218C>T	uc003tsx.2	+	4	442	c.173C>T	c.(172-174)GCT>GTT	p.A58V		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACAGGTATTGCTGTCTCTAAG	0.333													14	49					0	0	0	0
CLDN3	1365	broad.mit.edu	37	7	73183873	73183873	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:73183873G>T	uc003tzg.3	-	1	728	c.507C>A	c.(505-507)GCC>GCA	p.A169A	RFC2_uc011kfa.1_Intron	NM_001306	NP_001297	O15551	CLD3_HUMAN	claudin 3	169	Helical; (Potential).				response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				GCAGCGCCGCGGCCGCCCAGC	0.701													21	26					8.34094e-07	9.5325e-07	1	0
YWHAG	7532	broad.mit.edu	37	7	75988084	75988084	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:75988084G>T	uc011kgj.1	-	1	259	c.42C>A	c.(40-42)GCC>GCA	p.A14A		NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan	14					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						CCGCCTGCTCGGCCAGCCGGG	0.697													17	40					6.94344e-10	8.56267e-10	1	0
UPK3B	80761	broad.mit.edu	37	7	76140092	76140092	+	Silent	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:76140092C>A	uc003ufq.2	+	1	348	c.123C>A	c.(121-123)ACC>ACA	p.T41T	UPK3B_uc003ufo.2_Intron|UPK3B_uc010ldk.1_Intron	NM_030570	NP_085047	Q9BT76	UPK3B_HUMAN	uroplakin 3B isoform a	41	Lumenal (Potential).				negative regulation of gene expression	integral to membrane|plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(862;0.204)				CCAGCCAGACCCAAGGGGCTG	0.706													7	22					1.58986e-06	1.79724e-06	1	0
PCLO	27445	broad.mit.edu	37	7	82390032	82390032	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82390032C>A	uc003uhx.2	-	24	15500	c.15211G>T	c.(15211-15213)GTA>TTA	p.V5071L		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4994	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTCTGCATACTCTTGTTTTT	0.333													9	36					1.12685e-05	1.25117e-05	1	0
PCLO	27445	broad.mit.edu	37	7	82586052	82586052	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82586052G>T	uc003uhx.2	-	5	4506	c.4217C>A	c.(4216-4218)CCC>CAC	p.P1406H	PCLO_uc003uhv.2_Missense_Mutation_p.P1406H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1337					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAAATCTGAGGGGCTGGAAGG	0.398													16	59					1.02788e-11	1.30366e-11	1	0
SEMA3E	9723	broad.mit.edu	37	7	82996904	82996904	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82996904A>G	uc003uhy.1	-	17	2792	c.2326T>C	c.(2326-2328)TGA>CGA	p.*776R		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	776					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TCACCCCATCAGGAGTCCAGC	0.408													5	244					0	0	0	0
PON3	5446	broad.mit.edu	37	7	94996731	94996731	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:94996731T>C	uc003unt.2	-	5	462	c.437A>G	c.(436-438)GAG>GGG	p.E146G	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Missense_Mutation_p.E194G	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	146					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TTGTTGTTCCTCAAATTTAAA	0.348													3	132					0	0	0	0
RNF133	168433	broad.mit.edu	37	7	122338423	122338423	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:122338423T>C	uc003vkj.1	-	1	786	c.550A>G	c.(550-552)ATC>GTC	p.I184V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	184						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						ATCCAGATGATGTGCTTTCTC	0.378													28	73					0	0	0	0
NUP205	23165	broad.mit.edu	37	7	135304382	135304382	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:135304382G>T	uc003vsw.2	+	29	4206	c.4175G>T	c.(4174-4176)GGA>GTA	p.G1392V	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1392					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GCTTCTATTGGAGATTCTTCA	0.363													7	27					8.12818e-05	8.83621e-05	1	0
DGKI	9162	broad.mit.edu	37	7	137148266	137148266	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:137148266G>T	uc003vtt.2	-	28	2729	c.2728C>A	c.(2728-2730)CTG>ATG	p.L910M	DGKI_uc003vtu.2_Intron	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	910					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						AGATCTTTCAGATCTGAGTCC	0.522													21	42					1.01871e-10	1.27646e-10	1	0
ZNF425	155054	broad.mit.edu	37	7	148801945	148801945	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:148801945G>A	uc003wfj.2	-	4	1091	c.1018C>T	c.(1018-1020)CGC>TGC	p.R340C		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	340	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTCTTCAGGCGGAAGCACCGG	0.662													10	45					0	0	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939293	150939293	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:150939293G>A	uc003wjs.2	-	6	706	c.605C>T	c.(604-606)TCT>TTT	p.S202F	SMARCD3_uc003wjt.2_Missense_Mutation_p.S189F|SMARCD3_uc003wju.2_Missense_Mutation_p.S189F|SMARCD3_uc011kvh.1_Missense_Mutation_p.S202F|SMARCD3_uc010lqa.1_Missense_Mutation_p.S202F	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	202					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGAAAGAAGAGAACTTCCG	0.547													24	130					0	0	0	0
SCARA5	286133	broad.mit.edu	37	8	27779353	27779353	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:27779353G>A	uc003xgj.2	-	4	1091	c.651C>T	c.(649-651)GGC>GGT	p.G217G	SCARA5_uc010luz.2_Intron|SCARA5_uc003xgk.2_Silent_p.G174G|SCARA5_uc003xgl.2_Silent_p.G217G	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	217	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CCAGCTCCTCGCCCAGGATGC	0.721													4	3					0	0	0	0
GSR	2936	broad.mit.edu	37	8	30546804	30546804	+	Silent	SNP	C	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:30546804C>T	uc003xih.1	-	9	1006	c.915G>A	c.(913-915)TTG>TTA	p.L305L		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	305					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TGCTGACTTCCAAGCCCGACA	0.502													27	27					0	0	0	0
PRDM14	63978	broad.mit.edu	37	8	70970925	70970925	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:70970925G>C	uc003xym.2	-	6	1538	c.1336C>G	c.(1336-1338)CGG>GGG	p.R446G		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	446	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			ATCCGAAGCCGGTCCCGCTTC	0.502													28	64					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73849954	73849954	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:73849954T>A	uc003xzb.2	+	3	2952	c.2364T>A	c.(2362-2364)TTT>TTA	p.F788L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	788	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CCCCCAGGTTTCCCAAGCAGA	0.537													21	78					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139164289	139164289	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:139164289C>A	uc003yuy.2	-	13	2600	c.2429G>T	c.(2428-2430)GGA>GTA	p.G810V	FAM135B_uc003yux.2_Missense_Mutation_p.G711V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G372V|FAM135B_uc003yvb.2_Missense_Mutation_p.G372V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	810										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGAGCAAGATCCTGGGGAACC	0.537										HNSCC(54;0.14)			15	99					0.000219431	0.000236895	1	0
EIF2C2	27161	broad.mit.edu	37	8	141568597	141568597	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:141568597C>A	uc003yvn.2	-	7	905	c.865G>T	c.(865-867)GCC>TCC	p.A289S	EIF2C2_uc010men.2_Missense_Mutation_p.A212S|EIF2C2_uc010meo.2_Missense_Mutation_p.A289S	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	289	PAZ.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TGGTGACTGGCGGGCCGCCGG	0.597													65	84					9.65139e-37	1.3813e-36	1	0
KIAA2026	158358	broad.mit.edu	37	9	6007399	6007399	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:6007399G>A	uc003zjq.3	-	1	605	c.389C>T	c.(388-390)CCG>CTG	p.P130L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	130										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		GGGCTGCTGCGGGAAGGCGCG	0.706													24	19					0	0	0	0
SIGMAR1	10280	broad.mit.edu	37	9	34635731	34635731	+	Silent	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:34635731G>C	uc003zvb.2	-	4	644	c.570C>G	c.(568-570)GTC>GTG	p.V190V	SIGMAR1_uc003zva.3_Silent_p.V170V|SIGMAR1_uc003zuz.2_Silent_p.V101V|SIGMAR1_uc003zvc.2_Silent_p.V159V|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	190	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	GGGTGCTGAAGACAGTGTCGG	0.617													43	35					0	0	0	0
ZNF658	26149	broad.mit.edu	37	9	40772546	40772546	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:40772546T>C	uc004abs.2	-	5	2881	c.2729A>G	c.(2728-2730)TAT>TGT	p.Y910C	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.Y910C	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	910	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACTGCATTCATAGGGTTTCTC	0.443													139	120					0	0	0	0
RASEF	158158	broad.mit.edu	37	9	85616027	85616027	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:85616027A>T	uc004amo.1	-	10	1482	c.1221T>A	c.(1219-1221)TAT>TAA	p.Y407*		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	407					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CCTCATCCACATAGGAAGAGC	0.502													9	34					0	0	0	0
IARS	3376	broad.mit.edu	37	9	95027219	95027219	+	Silent	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:95027219G>C	uc004art.1	-	16	1949	c.1692C>G	c.(1690-1692)ACC>ACG	p.T564T	IARS_uc004ars.1_Silent_p.T409T|IARS_uc004aru.3_Silent_p.T564T|IARS_uc010mqr.2_Silent_p.T454T|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	564					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ACCATCCTCTGGTTTGGTCGA	0.398													9	35					0	0	0	0
ECM2	1842	broad.mit.edu	37	9	95274325	95274325	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:95274325T>A	uc004ash.2	-	5	1203	c.1138A>T	c.(1138-1140)ACT>TCT	p.T380S	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.T358S|ECM2_uc011lty.1_Missense_Mutation_p.T380S|ECM2_uc004asg.2_Missense_Mutation_p.T358S	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	380	LRR 1.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CCTGAAGAAGTGATATTATTT	0.403													11	50					0	0	0	0
CERCAM	51148	broad.mit.edu	37	9	131193524	131193524	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:131193524G>A	uc004buz.3	+	9	1543	c.1145G>A	c.(1144-1146)CGC>CAC	p.R382H	CERCAM_uc004buy.1_Missense_Mutation_p.R304H|CERCAM_uc010mxz.2_Missense_Mutation_p.R304H|CERCAM_uc010mya.1_Missense_Mutation_p.R223H	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	382					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TACTCGGGCCGCACTCTGACC	0.627													4	123					0	0	0	0
GLRA2	2742	broad.mit.edu	37	X	14708939	14708939	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:14708939G>A	uc010nep.2	+	9	1370	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K	GLRA2_uc010neq.2_Silent_p.K346K|GLRA2_uc004cwe.3_Silent_p.K346K|GLRA2_uc011mio.1_Silent_p.K257K|GLRA2_uc011mip.1_Silent_p.K324K	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	346	Cytoplasmic (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GGCAACACAAGGAGTTCCTGC	0.488													21	19					0	0	0	0
ZXDA	7789	broad.mit.edu	37	X	57934507	57934507	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:57934507G>C	uc004dve.2	-	1	2561	c.2348C>G	c.(2347-2349)TCT>TGT	p.S783C		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	783					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TTCTTTCTGAGAACCATGGTT	0.448													25	16					0	0	0	0
TAF1	6872	broad.mit.edu	37	X	70612767	70612767	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:70612767A>G	uc004dzu.3	+	20	3022	c.2971A>G	c.(2971-2973)ACA>GCA	p.T991A	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.T1012A|TAF1_uc004dzv.3_Missense_Mutation_p.T165A	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	991					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AGTGACAGGAACAGATGCAGA	0.428													52	31					0	0	0	0
XIST	7503	broad.mit.edu	37	X	73064128	73064128	+	RNA	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:73064128G>C	uc004ebm.1	-	1		c.8461C>G				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						AAGGGACATTGTTGTGGTCAA	0.388													51	43					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962848	73962848	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:73962848G>T	uc004eby.2	-	3	2161	c.1544C>A	c.(1543-1545)TCC>TAC	p.S515Y		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	515					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTCCTCTTTGGAACCAACTGG	0.388													5	7					3.59834e-05	3.93923e-05	1	0
Unknown	0	broad.mit.edu	37	X	80185525	80185525	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:80185525G>A	uc004eec.1	+	1	598	c.424G>A	c.(424-426)GAA>AAA	p.E142K						SubName: Full=cDNA FLJ16670 fis, clone THYMU3001133, highly similar to Voltage-dependent anion-selective channel protein 1; SubName: Full=Voltage-dependent anion channel 1, isoform CRA_a;																		CAAGACTGATGAATTCCAGCT	0.488													26	17					0	0	0	0
DACH2	117154	broad.mit.edu	37	X	85969652	85969652	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:85969652A>G	uc004eew.2	+	6	1203	c.1033A>G	c.(1033-1035)ACT>GCT	p.T345A	DACH2_uc004eex.2_Missense_Mutation_p.T332A|DACH2_uc010nmq.2_Missense_Mutation_p.T211A|DACH2_uc011mra.1_Missense_Mutation_p.T178A|DACH2_uc010nmr.2_Missense_Mutation_p.T126A|DACH2_uc004eey.2_Missense_Mutation_p.T28A|DACH2_uc004eez.2_Missense_Mutation_p.T28A	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCATCTCAATACTATTGCCAA	0.448													18	21					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105178437	105178437	+	Splice_Site	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:105178437G>T	uc004emd.2	+	20	3802	c.3499_splice	c.e20+1	p.L1167_splice	NRK_uc010npc.1_Splice_Site_p.L835_splice	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase								ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AGTGCCATCTGTGAGTGTGTT	0.368										HNSCC(51;0.14)			29	20					2.85442e-18	3.80589e-18	1	0
GLUD2	2747	broad.mit.edu	37	X	120181945	120181945	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:120181945G>A	uc004eto.2	+	1	484	c.407G>A	c.(406-408)CGG>CAG	p.R136Q		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	136					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	GAAGGCTACCGGGCCCAGCAC	0.592													26	10					0	0	0	0
IDS	3423	broad.mit.edu	37	X	148585743	148585743	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:148585743G>C	uc011mxe.1	-	2	382	c.184C>G	c.(184-186)CCA>GCA	p.P62A	IDS_uc011mxf.1_5'UTR|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Intron|IDS_uc011mxh.1_Missense_Mutation_p.P62A|IDS_uc011mxi.1_RNA|IDS_uc011mxj.1_Missense_Mutation_p.P62A	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	62						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TCAATATTTGGGGACCTCACC	0.562													4	9					0	0	0	0
GABRQ	55879	broad.mit.edu	37	X	151806746	151806746	+	Silent	SNP	G	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:151806746G>A	uc004ffp.1	+	1	110	c.90G>A	c.(88-90)CCG>CCA	p.P30P		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	30	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTCCCATCCCGAAATTCCACT	0.642													14	18					0	0	0	0
PNMA3	29944	broad.mit.edu	37	X	152226119	152226119	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:152226119T>A	uc004fhc.2	+	2	1043	c.707T>A	c.(706-708)TTG>TAG	p.L236*	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	236					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ctggctgccttgcagcaggtg	0													52	48					0	0	0	0
IL9R	3581	broad.mit.edu	37	X	155233507	155233507	+	Silent	SNP	G	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:155233507G>T	uc004fnv.1	+	4	599	c.420G>T	c.(418-420)CTG>CTT	p.L140L	IL9R_uc010nvn.2_Silent_p.L119L|IL9R_uc004fnu.1_Missense_Mutation_p.C185F	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	140	Extracellular (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGAGTACCTGCCCCGGAGAC	0.622													13	24					1.05317e-09	1.28858e-09	1	0
Unknown	0	broad.mit.edu	37	10	94969501	94969501	+	IGR	DEL	A	-	-	rs55900322	by1000genomes	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:94969501delA								CYP26A1 (131860 upstream) : MYOF (96686 downstream)																							CCCCCCCcccaaaaaaaaaac	0.219													---	---	---							
INSC	387755	broad.mit.edu	37	11	15197593	15197601	+	In_Frame_Del	DEL	CAGTGCTGT	-	-	rs61745109		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:15197593_15197601delCAGTGCTGT	uc001mly.2	+	3	550_558	c.504_512delCAGTGCTGT	c.(502-513)TACAGTGCTGTC>TAC	p.SAV169del	INSC_uc001mlz.2_In_Frame_Del_p.SAV122del|INSC_uc001mma.2_In_Frame_Del_p.SAV122del|INSC_uc010rcs.1_In_Frame_Del_p.SAV122del|INSC_uc001mmb.2_In_Frame_Del_p.SAV122del|INSC_uc001mmc.2_In_Frame_Del_p.SAV122del	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	169_171					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TCAGCGAGTACAGTGCTGTCAGCAGGAAC	0.612													---	---	---							
Unknown	0	broad.mit.edu	37	11	71532575	71532576	+	IGR	INS	-	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:71532575_71532576insT								FAM86C (20299 upstream) : DEFB108B (11670 downstream)																							CTTGCAGACACTTTAGGCACTA	0.426													---	---	---							
TP53	7157	broad.mit.edu	37	17	7576858	7576858	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:7576858delG	uc002gim.2	-	9	1182	c.988delC	c.(988-990)CTTfs	p.L330fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.L330fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Del_p.L198fs|TP53_uc010cng.1_Frame_Shift_Del_p.L198fs|TP53_uc002gii.1_Frame_Shift_Del_p.L198fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L330fs|TP53_uc010cni.1_Frame_Shift_Del_p.L330fs|TP53_uc002gij.2_Frame_Shift_Del_p.L330fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	330	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L330H(3)|p.?(1)|p.L330P(1)|p.L330R(1)|p.L330fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGTACCTGAAGGGTGAAATAT	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---							
Unknown	0	broad.mit.edu	37	17	20680269	20680270	+	IGR	INS	-	AAC	AAC	rs111615294		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:20680269_20680270insAAC								LGALS9B (309421 upstream) : CCDC144NL (86440 downstream)																							ACATCTGGAAAaacaacaacaa	0.173													---	---	---							
CARM1	10498	broad.mit.edu	37	19	11018818	11018818	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:11018818delC	uc002mpz.2	+	3	576	c.450delC	c.(448-450)TTCfs	p.F150fs	CARM1_uc010dxn.2_RNA	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	150					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						TGCAGTACTTCCAGGTGGGTT	0.612													---	---	---							
Unknown	0	broad.mit.edu	37	19	15694555	15694556	+	IGR	INS	-	T	T			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:15694555_15694556insT								CYP4F22 (31428 upstream) : CYP4F8 (31473 downstream)																							CACATGTGTACtttttttttgt	0.307													---	---	---							
Unknown	0	broad.mit.edu	37	19	21817605	21817605	+	IGR	DEL	G	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:21817605delG								ZNF429 (78537 upstream) : ZNF100 (89239 downstream)																							aaaaaaaaaagaaaaaaacaa	0.104													---	---	---							
Unknown	0	broad.mit.edu	37	2	92075769	92075770	+	IGR	INS	-	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:92075769_92075770insA								GGT8P (105616 upstream) : FKSG73 (53389 downstream)																							ACAATGATAATAAAAATGAATA	0.297													---	---	---							
Unknown	0	broad.mit.edu	37	2	133020192	133020193	+	IGR	INS	-	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:133020192_133020193insA								NCRNA00164 (4650 upstream) : GPR39 (153954 downstream)																							TGTGTTCATACCACTGCAAAGA	0.401													---	---	---							
Unknown	0	broad.mit.edu	37	21	9865569	9865570	+	IGR	INS	-	A	A	rs77497487	by1000genomes	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:9865569_9865570insA								None (None upstream) : None (None downstream)																							CTGCTGAGTTTAAATCTTCCTT	0.490													---	---	---							
C21orf91	54149	broad.mit.edu	37	21	19165780	19165781	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:19165780_19165781insA	uc002yko.3	-	5	936_937	c.845_846insT	c.(844-846)CTGfs	p.L282fs	C21orf91_uc002ykm.2_5'Flank|C21orf91_uc002ykn.2_5'Flank|C21orf91_uc002ykq.3_Frame_Shift_Ins_p.L281fs|C21orf91_uc002ykp.3_3'UTR	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	282										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		GCCCTACTTGCAGACATGGTAA	0.475													---	---	---							
Unknown	0	broad.mit.edu	37	3	155831980	155831980	+	IGR	DEL	G	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:155831980delG								GMPS (176462 upstream) : KCNAB1 (6357 downstream)																							TGCTTCTGCAGGACTCATTTT	0.388													---	---	---							
SI	6476	broad.mit.edu	37	3	164735374	164735374	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:164735374delC	uc003fei.2	-	31	3783	c.3721delG	c.(3721-3723)GAAfs	p.E1241fs		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1241	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCATATAATTCCCGAACCTCT	0.338										HNSCC(35;0.089)			---	---	---							
HIST1H3H	8357	broad.mit.edu	37	6	27775211	27775211	+	5'Flank	DEL	C	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:27775211delC	uc003njm.2	+							NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h						blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TGACCCCTCGCCCCCCAGTGA	0.418													---	---	---							
LAMA4	3910	broad.mit.edu	37	6	112537599	112537601	+	In_Frame_Del	DEL	GTT	-	-			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:112537599_112537601delGTT	uc003pvu.2	-	3	574_576	c.265_267delAAC	c.(265-267)AACdel	p.N89del	LAMA4_uc003pvv.2_In_Frame_Del_p.N89del|LAMA4_uc003pvt.2_In_Frame_Del_p.N89del|LAMA4_uc003pvw.2_In_Frame_Del_p.N89del	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	89	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CCAAACACTCGTTGGAATTGCCA	0.453													---	---	---							
FAM9A	171482	broad.mit.edu	37	X	8764319	8764320	+	Frame_Shift_Ins	INS	-	T	T	rs1985393		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:8764319_8764320insT	uc004csg.2	-	6	588_589	c.477_478insA	c.(475-480)AAACAAfs	p.K159fs		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	159_160						nucleolus					0		Hepatocellular(5;0.219)				CTTTTTAGTTGTTTTTTTTTCA	0.292													---	---	---							
APOO	79135	broad.mit.edu	37	X	23897090	23897091	+	Frame_Shift_Ins	INS	-	GCTGGCTC	GCTGGCTC			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:23897090_23897091insGCTGGCTC	uc004dax.2	-	3	409_410	c.178_179insGAGCCAGC	c.(178-180)CTTfs	p.L60fs	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	60					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						GCTTTCTTCAAGCTGGCTCCTT	0.441													---	---	---							
