Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
C1orf187	374946	broad.mit.edu	37	1	11766403	11766403	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:11766403C>T	uc001asr.1	+	2	228	c.88C>T	c.(88-90)CCT>TCT	p.P30S		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	30					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		CGCCCTTGCACCTGGGACCCC	0.706000													6	19					0	0	0	0
AHDC1	27245	broad.mit.edu	37	1	27874932	27874932	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:27874932C>T	uc009vsy.2	-	6	4664	c.3695G>A	c.(3694-3696)GGC>GAC	p.G1232D	AHDC1_uc009vsz.1_Missense_Mutation_p.G1232D	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1232							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCGTCCACGGCCCGGCTTGGA	0.607000													8	25					0	0	0	0
FUBP1	8880	broad.mit.edu	37	1	78433858	78433858	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:78433858G>A	uc001dii.2	-	3	330	c.241C>T	c.(241-243)CAA>TAA	p.Q81*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.Q102*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	81					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CAGTCATTTTGAGGAGCAACT	0.313000													6	28					0	0	0	0
PTGS2	5743	broad.mit.edu	37	1	186648488	186648488	+	Silent	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:186648488G>A	uc001gsb.2	-	2	272	c.135C>T	c.(133-135)ACC>ACT	p.T45T	PTGS2_uc009wyo.2_5'UTR	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	45	EGF-like.				cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	ATCCTGTCCGGGTACAATCGC	0.443000													19	30					0	0	0	0
RBM34	23029	broad.mit.edu	37	1	235324259	235324259	+	Silent	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:235324259G>C	uc001hwn.2	-	2	207	c.177C>G	c.(175-177)CTC>CTG	p.L59L	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Silent_p.L59L	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	59						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GAGAACTGAAGAGGGACGCCA	0.567000													9	45					0	0	0	0
A1CF	29974	broad.mit.edu	37	10	52576013	52576013	+	Silent	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr10:52576013G>A	uc001jjj.2	-	9	1082	c.894C>T	c.(892-894)GTC>GTT	p.V298V	A1CF_uc010qhn.1_Silent_p.V306V|A1CF_uc001jji.2_Silent_p.V298V|A1CF_uc001jjh.2_Silent_p.V306V|A1CF_uc010qho.1_Silent_p.V306V|A1CF_uc009xov.2_Silent_p.V298V	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	298	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TTGCTAGGGTGACTTCAATGG	0.478000													16	40					0	0	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70960106	70960106	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr10:70960106G>A	uc001jpe.1	+	11	1424	c.1369G>A	c.(1369-1371)GAA>AAA	p.E457K	SUPV3L1_uc010qjd.1_Missense_Mutation_p.E326K	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	457	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						GAGAGAACTAGAACCAATCAC	0.413000													22	73					0	0	0	0
TEAD1	7003	broad.mit.edu	37	11	12901270	12901270	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:12901270G>T	uc001mkj.3	+	6	966	c.301G>T	c.(301-303)GAT>TAT	p.D101Y	TEAD1_uc001mkk.3_Missense_Mutation_p.D20Y|TEAD1_uc009ygl.2_5'UTR	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	116					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GACTGCAAAGGATAAGGCCCT	0.562000													5	62					2.0095e-06	2.47511e-06	1	0
AHNAK	79026	broad.mit.edu	37	11	62293150	62293150	+	Silent	SNP	T	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:62293150T>C	uc001ntl.2	-	5	9039	c.8739A>G	c.(8737-8739)GAA>GAG	p.E2913E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2913					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCACATCCACTTCAGGGCCCT	0.517000													76	294					0	0	0	0
C11orf82	220042	broad.mit.edu	37	11	82644784	82644784	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:82644784G>C	uc001ozt.2	+	6	2648	c.2404G>C	c.(2404-2406)GAT>CAT	p.D802H	C11orf82_uc010rsr.1_Missense_Mutation_p.D501H|C11orf82_uc010rss.1_Missense_Mutation_p.D501H|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	802					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TTCAGATCTTGATGGTAACTA	0.363000													3	23					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49434776	49434776	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr12:49434776C>G	uc001rta.3	-	31	6777	c.6777G>C	c.(6775-6777)GAG>GAC	p.E2259D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2259	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCCAGGGCTCTCAGGCACAG	0.637000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	77					0	0	0	0
ACAD10	80724	broad.mit.edu	37	12	112150388	112150388	+	Silent	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr12:112150388G>A	uc001tsq.2	+	6	977	c.777G>A	c.(775-777)GTG>GTA	p.V259V	ACAD10_uc001tso.3_Silent_p.V259V|ACAD10_uc001tsp.2_Silent_p.V259V|ACAD10_uc009zvx.2_Silent_p.V290V|ACAD10_uc001tsr.2_5'UTR|ACAD10_uc001tss.1_5'Flank	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	259							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CTCGGCCTGTGAAAAAGACGA	0.438000													26	206					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58299273	58299273	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:58299273C>T	uc001vhq.1	+	4	4217	c.3325C>T	c.(3325-3327)CGG>TGG	p.R1109W	PCDH17_uc010aec.1_Missense_Mutation_p.R1108W|PCDH17_uc001vhr.1_Missense_Mutation_p.R198W	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1109	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGAGCCAGCCGGGATTCCAG	0.522000													6	203					0	0	0	0
DIAPH3	81624	broad.mit.edu	37	13	60545216	60545216	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:60545216G>A	uc001vht.2	-	16	1948	c.1729C>T	c.(1729-1731)CCT>TCT	p.P577S	DIAPH3_uc001vhu.2_Missense_Mutation_p.P314S|DIAPH3_uc001vhv.2_Missense_Mutation_p.P155S	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	577	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAGGCGGAGGAGGAAGTGCT	0.552000													5	31					0	0	0	0
LMO7	4008	broad.mit.edu	37	13	76419476	76419476	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:76419476T>C	uc001vjv.2	+	23	4172	c.3412T>C	c.(3412-3414)TCT>CCT	p.S1138P	LMO7_uc010thv.1_Missense_Mutation_p.S1089P|LMO7_uc001vjt.1_Missense_Mutation_p.S1037P|LMO7_uc010thw.1_Missense_Mutation_p.S1015P|LMO7_uc001vjw.1_Missense_Mutation_p.S1044P	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1423						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TAAATCCAGATCTACTACTGA	0.313000													6	16					0	0	0	0
SLC7A7	9056	broad.mit.edu	37	14	23243214	23243214	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr14:23243214C>T	uc001wgr.3	-	9	1495	c.1357G>A	c.(1357-1359)GGC>AGC	p.G453S	SLC7A7_uc001wgs.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgt.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgu.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgv.3_Missense_Mutation_p.G453S	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	453	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		AAGGGCAGGCCTGAGAGGGCA	0.522000													15	45					0	0	0	0
C14orf37	145407	broad.mit.edu	37	14	58605875	58605875	+	Silent	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr14:58605875G>A	uc001xdc.2	-	2	313	c.202C>T	c.(202-204)CTG>TTG	p.L68L	C14orf37_uc010tro.1_Silent_p.L106L|C14orf37_uc001xdd.2_Silent_p.L68L|C14orf37_uc001xde.2_Silent_p.L68L	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	68	Extracellular (Potential).					integral to membrane	binding				0						GAGACCACCAGTTGGGGAGTC	0.453000													40	136					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	107170012	107170012	+	RNA	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr14:107170012G>A	uc010tyt.1	-	39		c.2775C>T								Parts of antibodies, mostly variable regions.												0						ATTTGTCCGCGGTAATCGTGA	0.547000													47	327					0	0	0	0
CLN6	54982	broad.mit.edu	37	15	68503628	68503628	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr15:68503628T>A	uc002arf.2	-	5	673	c.515A>T	c.(514-516)TAT>TTT	p.Y172F	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Missense_Mutation_p.Y204F	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	172					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						GTACTCATCATAATAGTAGAG	0.602000													24	65					0	0	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709052	74709052	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr15:74709052G>C	uc002axv.2	-	7	705	c.665C>G	c.(664-666)CCA>CGA	p.P222R	SEMA7A_uc010ulk.1_Missense_Mutation_p.P57R|SEMA7A_uc010ull.1_Missense_Mutation_p.P208R	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	222	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GATGAACTGTGGGTCTGCCAG	0.567000													22	84					0	0	0	0
ALG1	56052	broad.mit.edu	37	16	5129756	5129756	+	Silent	SNP	A	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr16:5129756A>G	uc002cym.2	+	9	950	c.909A>G	c.(907-909)GAA>GAG	p.E303E	ALG1_uc002cyj.2_Silent_p.E192E|ALG1_uc002cyn.2_Silent_p.E303E|ALG1_uc010bue.2_Silent_p.E192E|ALG1_uc010uxy.1_Silent_p.E192E	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	303	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				CAGAGTTTGAACAACTGACTC	0.348000													3	126					0	0	0	0
NUBP1	4682	broad.mit.edu	37	16	10846524	10846524	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr16:10846524G>A	uc002daa.1	+	4	339	c.316G>A	c.(316-318)GAA>AAA	p.E106K	NUBP1_uc010bum.1_Missense_Mutation_p.G12E|NUBP1_uc002dab.1_Missense_Mutation_p.E106K	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	106					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						AATGGGATTGGAAGGAGAGCA	0.438000													22	118					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27561047	27561047	+	Silent	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr16:27561047C>T	uc002dov.1	-	1	205	c.165G>A	c.(163-165)CCG>CCA	p.P55P	GTF3C1_uc002dou.2_Silent_p.P55P|KIAA0556_uc002dow.2_5'Flank	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	55						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGCTGATGCCCGGGTGCGTGG	0.632000													4	28					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577568	7577568	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	48					5.60225e-13	7.16237e-13	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	C	C	rs141357429	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr17:39274087G>C	uc002hvz.2	-	1	520	c.481C>G	c.(481-483)CTG>GTG	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.323000													3	12					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522000													3	76					0	0	0	0
GIPC1	10755	broad.mit.edu	37	19	14591280	14591280	+	Silent	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:14591280G>A	uc002myt.2	-	6	762	c.492C>T	c.(490-492)AGC>AGT	p.S164S	GIPC1_uc002myu.2_Silent_p.S164S|GIPC1_uc002myv.2_Silent_p.S67S|GIPC1_uc002myw.2_Silent_p.S67S|GIPC1_uc002myx.2_Silent_p.S164S|GIPC1_uc002myy.2_Silent_p.S67S	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	164	PDZ.				endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GGTCGATCACGCTGCCCTCCT	0.682000											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	67					0	0	0	0
ZNF671	79891	broad.mit.edu	37	19	58232120	58232120	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:58232120C>T	uc002qpz.3	-	4	1433	c.1334G>A	c.(1333-1335)AGA>AAA	p.R445K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.R368K|ZNF671_uc010yhf.1_Missense_Mutation_p.R347K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	445	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCTGTGAATTCTCCAGTGTAC	0.463000													17	57					0	0	0	0
KCNF1	3754	broad.mit.edu	37	2	11053827	11053827	+	Silent	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:11053827C>T	uc002rax.2	+	1	1765	c.1275C>T	c.(1273-1275)CAC>CAT	p.H425H		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	425	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGGCCAAGCACGAGCTGGAGC	0.632000													6	28					0	0	0	0
FNDC4	64838	broad.mit.edu	37	2	27715571	27715571	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:27715571C>A	uc002rkx.2	-	6	1037	c.631G>T	c.(631-633)GAA>TAA	p.E211*	IFT172_uc002rku.2_5'Flank|IFT172_uc002rkw.2_5'Flank|IFT172_uc010yls.1_5'Flank|IFT172_uc010ezc.2_5'Flank|IFT172_uc002rkv.2_5'Flank|IFT172_uc010ylt.1_5'Flank	NM_022823	NP_073734	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	211	Cytoplasmic (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					GGACTCTGTTCCGGCCCCTTT	0.552000													21	61					1.55795e-14	2.01734e-14	1	0
RTKN	6242	broad.mit.edu	37	2	74653510	74653510	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:74653510T>C	uc002sle.2	-	12	1669	c.1552A>G	c.(1552-1554)ACC>GCC	p.T518A	RTKN_uc002slc.2_Missense_Mutation_p.T505A|RTKN_uc002sld.2_Missense_Mutation_p.T468A	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	518	Pro-rich.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						AGGGAAAAGGTTCGGGGTCTC	0.677000													23	80					0	0	0	0
RTKN	6242	broad.mit.edu	37	2	74654585	74654585	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:74654585C>T	uc002sle.2	-	10	1338	c.1221G>A	c.(1219-1221)TGG>TGA	p.W407*	RTKN_uc002slc.2_Nonsense_Mutation_p.W394*|RTKN_uc002sld.2_Nonsense_Mutation_p.W357*	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	407	PH.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						GAGCCTCCATCCAGCTCTGCA	0.502000													60	198					0	0	0	0
TMEM87B	84910	broad.mit.edu	37	2	112821764	112821764	+	Silent	SNP	T	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:112821764T>C	uc002thm.2	+	3	621	c.252T>C	c.(250-252)CCT>CCC	p.P84P	TMEM87B_uc010fkg.2_Silent_p.P84P|TMEM87B_uc010fkh.2_Silent_p.P84P	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	84						integral to membrane					0						GTTCTGGGCCTGTGAAGTTTA	0.308000													3	144					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141474362	141474362	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:141474362C>G	uc002tvj.1	-	36	6754	c.5782G>C	c.(5782-5784)GAC>CAC	p.D1928H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1928	Extracellular (Potential).|LDL-receptor class B 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGCCCATGTCTGTCCAGTAG	0.363000										TSP Lung(27;0.18)			3	77					0	0	0	0
GALNT5	11227	broad.mit.edu	37	2	158140861	158140861	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:158140861G>C	uc002tzg.2	+	2	1777	c.1522G>C	c.(1522-1524)GTG>CTG	p.V508L	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	508	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TGTGGATGAAGTGTGGTCCAC	0.488000													21	59					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165987855	165987855	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:165987855C>G	uc002ucx.2	-	16	2956	c.2464G>C	c.(2464-2466)GAA>CAA	p.E822Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E773Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E773Q|SCN3A_uc002uda.1_Missense_Mutation_p.E642Q|SCN3A_uc002udb.1_Missense_Mutation_p.E642Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	822						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCCAGCCTTCTTGGAAATAG	0.393000													13	76					0	0	0	0
BMPR2	659	broad.mit.edu	37	2	203332371	203332371	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:203332371A>G	uc002uzf.3	+	3	1525	c.377A>G	c.(376-378)AAC>AGC	p.N126S	BMPR2_uc010ftr.2_Missense_Mutation_p.N126S|BMPR2_uc002uze.2_Missense_Mutation_p.N126S	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	126	Extracellular (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						TGTAATGTCAACTTTACTGAG	0.368000													14	32					0	0	0	0
EPHA4	2043	broad.mit.edu	37	2	222321461	222321461	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:222321461C>T	uc002vmq.2	-	7	1517	c.1475G>A	c.(1474-1476)CGG>CAG	p.R492Q	EPHA4_uc002vmr.2_Missense_Mutation_p.R492Q|EPHA4_uc010zlm.1_Missense_Mutation_p.R433Q|EPHA4_uc010zln.1_Missense_Mutation_p.R492Q	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	492	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GGCAGCTGTCCGAACTATACG	0.468000													14	65					0	0	0	0
FAM113A	64773	broad.mit.edu	37	20	2816812	2816812	+	Silent	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr20:2816812C>T	uc002wgz.1	-	7	1487	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q	FAM113A_uc002whb.1_Silent_p.Q181Q|FAM113A_uc002wha.1_Silent_p.Q181Q|FAM113A_uc010zqa.1_Silent_p.Q177Q|FAM113A_uc002whc.1_Silent_p.Q279Q	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	330							hydrolase activity|protein binding			ovary(2)	2						gtggcgagggctgaggaagcg	0.284000													12	40					0	0	0	0
PREX1	57580	broad.mit.edu	37	20	47266745	47266745	+	Splice_Site	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr20:47266745C>T	uc002xtw.1	-	24	2841	c.2818_splice	c.e24-1	p.F940_splice	PREX1_uc002xtv.1_Splice_Site_p.F237_splice	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,						actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGGCTGCAAACTGAGAAAGTG	0.592000													21	63					0	0	0	0
GTSE1	51512	broad.mit.edu	37	22	46725347	46725347	+	Silent	SNP	C	T	T	rs61737807	byFrequency	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr22:46725347C>T	uc011aqy.1	+	11	2231	c.2019C>T	c.(2017-2019)TGC>TGT	p.C673C	GTSE1_uc011aqz.1_Silent_p.C520C|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	654					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TCGACTTCTGCGATACCCCAG	0.507000													40	133					0	0	0	0
HGD	3081	broad.mit.edu	37	3	120394679	120394679	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:120394679G>A	uc003edw.2	-	2	417	c.47C>T	c.(46-48)TCA>TTA	p.S16L		NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	16					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		AGGATCCTCTGAAGAACACTC	0.438000													23	76					0	0	0	0
PIK3CB	5291	broad.mit.edu	37	3	138383967	138383967	+	Silent	SNP	A	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:138383967A>C	uc011bmq.1	-	18	2583	c.2583T>G	c.(2581-2583)GCT>GCG	p.A861A	PIK3CB_uc011bmn.1_Silent_p.A373A|PIK3CB_uc011bmo.1_Silent_p.A312A|PIK3CB_uc011bmp.1_Silent_p.A448A	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	861	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCTGAATGTCAGCAATTGTTT	0.448000													10	35					0	0	0	0
FXR1	8087	broad.mit.edu	37	3	180693130	180693130	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:180693130G>A	uc003fkq.2	+	16	1655	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K	FXR1_uc003fkp.2_Missense_Mutation_p.E460K|FXR1_uc003fkr.2_Intron|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_Missense_Mutation_p.E488K|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Missense_Mutation_p.E532K	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	545					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TTCTAGAGCTGAGTCTCAGAG	0.308000													3	10					0	0	0	0
AFAP1	60312	broad.mit.edu	37	4	7774605	7774605	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:7774605G>A	uc003gkg.1	-	15	2216	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	AFAP1_uc011bwk.1_Missense_Mutation_p.A732V|LOC84740_uc003gkd.3_RNA	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	648	Potential.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						GACTCCGCCCGCCAGCGCTTT	0.657000													4	35					0	0	0	0
KDR	3791	broad.mit.edu	37	4	55964338	55964338	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:55964338G>T	uc003has.2	-	17	2777	c.2475C>A	c.(2473-2475)AGC>AGA	p.S825R	KDR_uc003hat.1_Missense_Mutation_p.S825R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	825	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ATTCCCATTTGCTGGCATCAT	0.453000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			14	60					6.31663e-08	7.87629e-08	1	0
LIN54	132660	broad.mit.edu	37	4	83849335	83849335	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:83849335C>G	uc003hnx.3	-	13	2548	c.2170G>C	c.(2170-2172)GAG>CAG	p.E724Q	LIN54_uc003hnz.3_Missense_Mutation_p.E503Q|LIN54_uc003hny.3_Missense_Mutation_p.E323Q|LIN54_uc010ijt.2_Missense_Mutation_p.E635Q|LIN54_uc010iju.2_Missense_Mutation_p.E323Q|LIN54_uc010ijv.2_Missense_Mutation_p.E503Q	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	724					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				CCGAATTCCTCAAGTATCATC	0.468000													4	76					0	0	0	0
EGF	1950	broad.mit.edu	37	4	110866357	110866357	+	Missense_Mutation	SNP	T	A	A	rs139711858		TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:110866357T>A	uc003hzy.3	+	5	1318	c.866T>A	c.(865-867)TTT>TAT	p.F289Y	EGF_uc011cfu.1_Missense_Mutation_p.F289Y|EGF_uc011cfv.1_Missense_Mutation_p.F289Y	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	289	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CATTCATCATTTGTACCACTT	0.448000													9	28					0	0	0	0
C4orf21	55345	broad.mit.edu	37	4	113533743	113533743	+	Silent	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:113533743C>G	uc003iau.2	-	7	2815	c.2604G>C	c.(2602-2604)GTG>GTC	p.V868V	C4orf21_uc003iaw.2_Silent_p.V868V	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATGGTTTCCTCACTGTAATGG	0.284000													5	27					0	0	0	0
RGMB	285704	broad.mit.edu	37	5	98115428	98115428	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:98115428G>A	uc003knc.2	+	4	806	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	RGMB_uc003knb.2_Missense_Mutation_p.R135Q	NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	94					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TGCACCCAGCGAACTTCAAAA	0.542000													11	89					0	0	0	0
HSD17B4	3295	broad.mit.edu	37	5	118872146	118872146	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:118872146A>C	uc003ksj.2	+	23	2145	c.2022A>C	c.(2020-2022)AAA>AAC	p.K674N	HSD17B4_uc011cwg.1_Missense_Mutation_p.K650N|HSD17B4_uc011cwh.1_Missense_Mutation_p.K656N|HSD17B4_uc011cwi.1_Missense_Mutation_p.K699N|HSD17B4_uc003ksk.3_Missense_Mutation_p.K527N|HSD17B4_uc011cwj.1_Missense_Mutation_p.K527N|HSD17B4_uc010jcn.1_Missense_Mutation_p.K412N|HSD17B4_uc010jco.1_Intron	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	674	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GTTCTGGAAAAGTGTACCAAG	0.418000													11	43					0	0	0	0
PCDHB17	54661	broad.mit.edu	37	5	140536957	140536957	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:140536957G>T	uc003lis.2	+	1	1378	c.1378G>T	c.(1378-1380)GTC>TTC	p.V460F		NR_001280				SubName: Full=Protocadherin-psi1;												0						CACCCTGTTCGTCCGCGAGAA	0.622000													23	137					2.21704e-12	2.79901e-12	1	0
ZNF300	91975	broad.mit.edu	37	5	150275429	150275429	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:150275429C>A	uc003lsy.1	-	6	1639	c.1372G>T	c.(1372-1374)GTT>TTT	p.V458F	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	458	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGTATGAACTAACTGATGT	0.398000													9	44					0.000274275	0.000333756	1	0
CD2AP	23607	broad.mit.edu	37	6	47501441	47501441	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr6:47501441T>G	uc003oyw.2	+	3	725	c.269T>G	c.(268-270)CTT>CGT	p.L90R		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	90	Interaction with ANLN and localization to the midbody.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACCTATGGACTTCCAGCTGGA	0.383000													7	20					0	0	0	0
BMPER	168667	broad.mit.edu	37	7	34118794	34118794	+	Silent	SNP	A	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:34118794A>G	uc011kap.1	+	12	1518	c.1404A>G	c.(1402-1404)AAA>AAG	p.K468K		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	468	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGACCACCAAAGCAGGTGGGG	0.622000													12	59					0	0	0	0
LIMK1	3984	broad.mit.edu	37	7	73523259	73523259	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:73523259C>T	uc003uaa.1	+	10	1342	c.1177C>T	c.(1177-1179)CAC>TAC	p.H393Y	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.H359Y|LIMK1_uc003uac.1_Missense_Mutation_p.H185Y	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	393	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				ATGCCTGGAACACCCCAACGT	0.562000													18	36					0	0	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117351760	117351760	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:117351760C>G	uc003vjf.2	-	23	4915	c.4823G>C	c.(4822-4824)AGA>ACA	p.R1608T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1608										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AGATTTAACTCTTGAAACACC	0.423000													3	71					0	0	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163187	163187	+	RNA	SNP	T	C	C	rs143599805	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:163187T>C	uc010lra.2	-	4		c.946A>G			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						TGAAAAACATTATTCTTTTAT	0.209000													4	23					0	0	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163191	163191	+	RNA	SNP	C	T	T	rs147223236	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:163191C>T	uc010lra.2	-	4		c.942G>A			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						AAACATTATTCTTTTATGGTG	0.219000													4	24					0	0	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163215	163215	+	RNA	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:163215G>A	uc010lra.2	-	4		c.918C>T			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						AGATACACATGTATTTAGAGT	0.274000													5	34					0	0	0	0
KIAA0146	23514	broad.mit.edu	37	8	48353089	48353089	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:48353089G>A	uc003xqd.2	+	8	1091	c.1082G>A	c.(1081-1083)CGG>CAG	p.R361Q	KIAA0146_uc011lcz.1_RNA|KIAA0146_uc011lda.1_Missense_Mutation_p.R50Q|KIAA0146_uc011ldb.1_Missense_Mutation_p.R361Q|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.R291Q|KIAA0146_uc011ldd.1_Missense_Mutation_p.R301Q|KIAA0146_uc003xqe.2_5'UTR|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.R50Q|KIAA0146_uc010lxt.2_Missense_Mutation_p.R50Q	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	361											0		Lung NSC(58;0.175)				GACACTGTCCGGATCTTCCCT	0.532000													16	72					0	0	0	0
EYA1	2138	broad.mit.edu	37	8	72267106	72267106	+	Missense_Mutation	SNP	C	T	T	rs74720958	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:72267106C>T	uc003xys.3	-	2	322	c.35G>A	c.(34-36)CGT>CAT	p.R12H	EYA1_uc003xyr.3_Missense_Mutation_p.R12H|EYA1_uc003xyt.3_Intron|EYA1_uc010lzf.2_5'UTR|EYA1_uc003xyu.2_Missense_Mutation_p.R12H|EYA1_uc011lfe.1_Missense_Mutation_p.R12H|EYA1_uc003xyv.2_5'UTR	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	12					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCACTCAGACGGCTATGCGG	0.458000													51	125					0	0	0	0
RNF19A	25897	broad.mit.edu	37	8	101299799	101299799	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:101299799C>T	uc003yjj.1	-	3	921	c.604G>A	c.(604-606)GAA>AAA	p.E202K	RNF19A_uc003yjk.1_Missense_Mutation_p.E202K|RNF19A_uc003yjl.1_Missense_Mutation_p.E202K	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	202	IBR-type.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ATAAATTCTTCGTATTTTTCC	0.388000													7	96					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971208	21971208	+	Splice_Site	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:21971208C>T	uc003zpk.2	-	2	363	c.151_splice	c.e2-1	p.V51_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site_p.G106_splice	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(28)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCATCATGACCTGCCAGAGAG	0.667000		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507309	130507309	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:130507309C>T	uc004bsc.2	-	7	1476	c.1334G>A	c.(1333-1335)CGT>CAT	p.R445H	SH2D3C_uc010mxo.2_Missense_Mutation_p.R285H|SH2D3C_uc004bry.2_Missense_Mutation_p.R287H|SH2D3C_uc004brz.3_Missense_Mutation_p.R91H|SH2D3C_uc011mak.1_Missense_Mutation_p.R91H|SH2D3C_uc004bsa.2_Missense_Mutation_p.R288H|SH2D3C_uc004bsb.2_Missense_Mutation_p.R377H	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	445				R -> C (in Ref. 1; AAD28246 and 2; AAQ89948).	JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CTCACTGGAACGGCGGGCGAC	0.657000													65	49					0	0	0	0
SETX	23064	broad.mit.edu	37	9	135203150	135203150	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:135203150C>G	uc004cbk.2	-	10	4018	c.3835G>C	c.(3835-3837)GAG>CAG	p.E1279Q	SETX_uc004cbj.2_Missense_Mutation_p.E898Q|SETX_uc010mzt.2_Missense_Mutation_p.E898Q	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1279					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GAAGTTGGCTCAGGACACTGA	0.428000													26	177					0	0	0	0
NHS	4810	broad.mit.edu	37	X	17710476	17710476	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:17710476G>A	uc004cxx.2	+	3	1078	c.740G>A	c.(739-741)CGC>CAC	p.R247H	NHS_uc011mix.1_Missense_Mutation_p.R247H|NHS_uc004cxy.2_Missense_Mutation_p.R70H|NHS_uc004cxz.2_Missense_Mutation_p.R70H|NHS_uc004cya.2_5'UTR	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	247						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CGGAGCGATCGCCGAGAGCAA	0.527000													28	65					0	0	0	0
PDHA1	5160	broad.mit.edu	37	X	19373621	19373621	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:19373621G>C	uc004czg.3	+	7	903	c.758G>C	c.(757-759)AGA>ACA	p.R253T	PDHA1_uc004czh.3_Missense_Mutation_p.R288T|PDHA1_uc011mjc.1_Missense_Mutation_p.R257T|PDHA1_uc011mjd.1_Missense_Mutation_p.R219T|PDHA1_uc010nfk.2_Missense_Mutation_p.R250T|PDHA1_uc010nfl.2_Missense_Mutation_p.R44T	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	253					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	CCTGGGCTGAGAGTAAGGACA	0.512000													8	126					0	0	0	0
ZNF157	7712	broad.mit.edu	37	X	47272940	47272940	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:47272940A>G	uc004dhr.1	+	4	1537	c.1468A>G	c.(1468-1470)AGA>GGA	p.R490G		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	490	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGAACATCAGAGAACTCACAT	0.488000													14	46					0	0	0	0
TEX11	56159	broad.mit.edu	37	X	69826836	69826836	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:69826836C>T	uc004dyl.2	-	24	2130	c.1968G>A	c.(1966-1968)ATG>ATA	p.M656I	TEX11_uc004dyk.2_Missense_Mutation_p.M331I|TEX11_uc004dym.2_Missense_Mutation_p.M641I	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	656							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AAAACTCTCTCATCATCACTG	0.318000													3	30					0	0	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388597	119388597	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:119388597G>C	uc004esn.1	+	2	1555	c.1327G>C	c.(1327-1329)GAT>CAT	p.D443H	ZBTB33_uc010nqm.1_Missense_Mutation_p.D443H	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	443					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGATACTTATGATATAGTGAT	0.413000													13	85					0	0	0	0
Unknown	0	broad.mit.edu	37	10	82057637	82057637	+	IGR	DEL	T	-	-			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr10:82057637delT								MAT1A (8203 upstream) : DYDC1 (38227 downstream)																							CTATGTAttcttttttttttt	0.219													---	---	---							
Unknown	0	broad.mit.edu	37	11	9681924	9681924	+	IGR	DEL	A	-	-			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:9681924delA								WEE1 (70613 upstream) : SWAP70 (3704 downstream)																							acttcgtctcaaaaaaaaaaa	0.209													---	---	---							
Unknown	0	broad.mit.edu	37	12	27288144	27288144	+	IGR	DEL	A	-	-	rs11301501		TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr12:27288144delA								C12orf71 (52689 upstream) : STK38L (108934 downstream)																							CAGCACATTTAAAAAAAAAAA	0.348													---	---	---							
FLJ40330	645784	broad.mit.edu	37	2	89100762	89100766	+	RNA	DEL	TGAAT	-	-	rs74666751	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:89100762_89100766delTGAAT	uc010fhg.2	+	13		c.1202_1206delTGAAT			FLJ40330_uc010fhh.2_RNA|FLJ40330_uc010fhi.1_RNA	NR_015424				Homo sapiens mRNA; cDNA DKFZp434J1630 (from clone DKFZp434J1630).												0						GGTTGGTAAATGAATTGAATCATTT	0.332													---	---	---							
C6orf204	387119	broad.mit.edu	37	6	118887049	118887049	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr6:118887049delT	uc003pxz.1	-	3	1251	c.663delA	c.(661-663)AAAfs	p.K221fs	C6orf204_uc003pya.1_Frame_Shift_Del_p.K224fs|C6orf204_uc003pyb.2_Frame_Shift_Del_p.K221fs|C6orf204_uc011ebj.1_Frame_Shift_Del_p.K119fs|C6orf204_uc003pyc.2_Frame_Shift_Del_p.K224fs|C6orf204_uc011ebl.1_Frame_Shift_Del_p.K119fs	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	221						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTGATGACCGTTTTTTATTTA	0.418													---	---	---							
RELN	5649	broad.mit.edu	37	7	103629803	103629804	+	Translation_Start_Site	INS	-	GCCGCC	GCCGCC			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:103629803_103629804insGCCGCC	uc003vca.2	-	1					RELN_uc010liz.2_Translation_Start_Site	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCGCTCCATgccgccgccgc	0.569													---	---	---							
Unknown	0	broad.mit.edu	37	9	38643837	38643838	+	IGR	INS	-	A	A			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:38643837_38643838insA								C9orf122 (20562 upstream) : CNTNAP3 (428928 downstream)																							TTTGTGTGATTAAAAAAAAAAA	0.441													---	---	---							
