Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7724919	7724919	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:7724919A>T	uc001aoi.2	+	9	2519	c.2312A>T	c.(2311-2313)AAC>ATC	p.N771I		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	771					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCCTTCAGCAACCAGTTCTCC	0.627000													141	77					0	0	0	0
MST1P2	11209	broad.mit.edu	37	1	16976743	16976743	+	RNA	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:16976743C>T	uc010och.1	+	14		c.2464C>T			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						CCAGCCTTGACGCCATATGCT	0.393000													7	21					0	0	0	0
SERINC2	347735	broad.mit.edu	37	1	31896555	31896555	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:31896555G>A	uc010ogh.1	+	2	268	c.67G>A	c.(67-69)GGC>AGC	p.G23S	SERINC2_uc010ogg.1_Missense_Mutation_p.G20S|SERINC2_uc009vtw.1_Missense_Mutation_p.G19S|SERINC2_uc001bst.2_Missense_Mutation_p.G19S|SERINC2_uc001bsu.2_5'UTR|SERINC2_uc001bsv.2_5'UTR	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	19	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		CTGCCTCTGCGGCTCTGCCCC	0.677000													43	10					0	0	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580081	35580081	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:35580081A>G	uc001bym.2	+	11	2798	c.2650A>G	c.(2650-2652)ATA>GTA	p.I884V	ZMYM1_uc001byn.2_Missense_Mutation_p.I884V|ZMYM1_uc010ohu.1_Missense_Mutation_p.I865V|ZMYM1_uc001byo.2_Missense_Mutation_p.I524V|ZMYM1_uc009vut.2_Missense_Mutation_p.I809V	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	884						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAATAAAACCATAGACATTTT	0.313000													13	7					0	0	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149858147	149858147	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:149858147G>C	uc001etc.2	-	1	86	c.44C>G	c.(43-45)TCC>TGC	p.S15C	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCTTTCTTGGAGCCCTTTTT	0.537000													37	63					0	0	0	0
LINGO4	339398	broad.mit.edu	37	1	151774826	151774826	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:151774826G>A	uc001ezf.1	-	2	545	c.355C>T	c.(355-357)CGG>TGG	p.R119W		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	119	LRR 3.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATTCTGAGCCGATTGCCCTGC	0.577000													17	109					0	0	0	0
IGSF9	57549	broad.mit.edu	37	1	159904572	159904572	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:159904572G>A	uc001fur.2	-	7	912	c.714C>T	c.(712-714)GTC>GTT	p.V238V	IGSF9_uc001fuq.2_Silent_p.V238V|IGSF9_uc001fup.2_5'Flank	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	238	Ig-like 3.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGAGGCATTGACTGTGCTGT	0.562000													6	65					0	0	0	0
C1orf9	51430	broad.mit.edu	37	1	172555026	172555026	+	Silent	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:172555026T>G	uc001giq.3	+	17	1912	c.1596T>G	c.(1594-1596)ACT>ACG	p.T532T	C1orf9_uc010pmm.1_Silent_p.T532T|C1orf9_uc009wwd.2_Silent_p.T488T|C1orf9_uc010pmn.1_Silent_p.T495T|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	532					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		AGAATGCCACTGCCACAGCTG	0.244000													62	143					0	0	0	0
NPHS2	7827	broad.mit.edu	37	1	179544828	179544828	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:179544828G>C	uc001gmq.3	-	1	257	c.172C>G	c.(172-174)CGA>GGA	p.R58G	NPHS2_uc009wxi.2_Missense_Mutation_p.R58G	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	58	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						GCGGGCGCTCGGGGCTCCCCC	0.776000													5	11					0	0	0	0
CENPF	1063	broad.mit.edu	37	1	214825109	214825109	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:214825109C>T	uc001hkm.2	+	15	8214	c.8040C>T	c.(8038-8040)TGC>TGT	p.C2680C		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2776	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCCTAGATTGCATGCACAAAG	0.388000													18	36					0	0	0	0
KCTD3	51133	broad.mit.edu	37	1	215775490	215775490	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:215775490A>T	uc001hks.2	+	12	1379	c.1085A>T	c.(1084-1086)GAT>GTT	p.D362V	KCTD3_uc001hkt.2_Missense_Mutation_p.D362V|KCTD3_uc010pub.1_Missense_Mutation_p.D260V|KCTD3_uc009xdn.2_Missense_Mutation_p.D114V	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	362						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CTGTATCATGATCCTTCAAAT	0.303000													19	45					0	0	0	0
KCTD3	51133	broad.mit.edu	37	1	215792410	215792410	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:215792410A>G	uc001hks.2	+	16	2039	c.1745A>G	c.(1744-1746)AAG>AGG	p.K582R	KCTD3_uc001hkt.2_Missense_Mutation_p.K582R|KCTD3_uc010pub.1_Missense_Mutation_p.K480R|KCTD3_uc009xdn.2_Missense_Mutation_p.K306R	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	582						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		AGTGAAGATAAGGGTAGGTTC	0.393000													19	69					0	0	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561495	232561495	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:232561495C>G	uc001hvg.2	-	16	4628	c.4470G>C	c.(4468-4470)GAG>GAC	p.E1490D	SIPA1L2_uc001hvf.2_Missense_Mutation_p.E564D	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1490					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGCAGATGCTCTCGTCAGACA	0.552000													7	20					0	0	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394939	233394939	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:233394939G>A	uc001hvl.2	-	5	904	c.669C>T	c.(667-669)CTC>CTT	p.L223L	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	223						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TACCATTGATGAGAGTTTCTG	0.498000													12	111					0	0	0	0
EDARADD	128178	broad.mit.edu	37	1	236572548	236572548	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:236572548G>A	uc001hxu.1	+	2	159	c.94G>A	c.(94-96)GAC>AAC	p.D32N	EDARADD_uc001hxv.1_Missense_Mutation_p.D22N	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	32					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GGAAGACACAGACCCTAGCAC	0.308000													24	55					0	0	0	0
MLLT10	8028	broad.mit.edu	37	10	21823717	21823717	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:21823717C>G	uc001iqs.2	+	2	492	c.144C>G	c.(142-144)AGC>AGG	p.S48R	MLLT10_uc001iqt.2_Missense_Mutation_p.S48R|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S48R|MLLT10_uc001iqr.1_Missense_Mutation_p.S48R|MLLT10_uc001iqq.1_Missense_Mutation_p.S48R|MLLT10_uc001iqu.1_Missense_Mutation_p.S48R|MLLT10_uc009xke.1_RNA|MLLT10_uc001iqw.1_Missense_Mutation_p.S48R|MLLT10_uc001iqx.1_RNA|MLLT10_uc009xkf.1_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	48	PHD-type 1.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						ACGGCTGCAGCGTCGCGGTGC	0.408000			T	MLL|PICALM|CDK6	AL								4	37					0	0	0	0
ITGB1	3688	broad.mit.edu	37	10	33217097	33217097	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:33217097C>T	uc001iws.3	-	5	608	c.472G>A	c.(472-474)GAT>AAT	p.D158N	ITGB1_uc001iwp.3_Missense_Mutation_p.D158N|ITGB1_uc001iwq.3_Missense_Mutation_p.D158N|ITGB1_uc001iwr.3_Missense_Mutation_p.D158N|ITGB1_uc001iwt.3_Missense_Mutation_p.D158N|ITGB1_uc001iwu.1_Missense_Mutation_p.D158N	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	158	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTCTCCAAATCGTCTTTCATT	0.373000													52	87					0	0	0	0
NRAP	4892	broad.mit.edu	37	10	115393949	115393949	+	Silent	SNP	G	A	A	rs141308047		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:115393949G>A	uc001laj.2	-	15	1613	c.1449C>T	c.(1447-1449)ATC>ATT	p.I483I	NRAP_uc001lak.2_Silent_p.I448I|NRAP_uc001lal.3_Silent_p.I483I	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	483						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCAACTTGTCGATGCTCTGCC	0.458000													34	43					0	0	0	0
C10orf137	26098	broad.mit.edu	37	10	127438083	127438083	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:127438083C>T	uc001liq.1	+	22	3519	c.3226C>T	c.(3226-3228)CTG>TTG	p.L1076L	C10orf137_uc001lio.1_Silent_p.L1042L|C10orf137_uc001lip.1_Silent_p.L780L|C10orf137_uc001lis.1_Silent_p.L402L|C10orf137_uc001lit.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	1076					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TCCCTGCGAACTGCTTAGAGT	0.443000													27	22					0	0	0	0
OR52N4	390072	broad.mit.edu	37	11	5776926	5776926	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:5776926A>G	uc001mbu.2	+	1	1004	c.956A>G	c.(955-957)TAC>TGC	p.Y319C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	319	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		ACCAAATCCTACAGCATGTGA	0.413000													3	27					0	0	0	0
RAG2	5897	broad.mit.edu	37	11	36614176	36614176	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:36614176T>G	uc001mwv.3	-	2	1731	c.1543A>C	c.(1543-1545)ACT>CCT	p.T515P	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	515					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TTGGCAGGAGTCAAGATTTTT	0.373000									Familial_Hemophagocytic_Lymphohistiocytosis				17	15					0	0	0	0
OR5L2	26338	broad.mit.edu	37	11	55594934	55594934	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:55594934G>T	uc001nhy.1	+	1	240	c.240G>T	c.(238-240)AAG>AAT	p.K80N		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTGTGCCAAAGATGTTGGCTA	0.463000										HNSCC(27;0.073)			51	110					6.08268e-21	6.8937e-21	1	0
OR5AR1	219493	broad.mit.edu	37	11	56431630	56431630	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:56431630G>T	uc010rjm.1	+	1	469	c.469G>T	c.(469-471)GTA>TTA	p.V157L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGTGAGTTTAGTAGCCCACAC	0.512000													65	74					5.82089e-37	6.70882e-37	1	0
INPPL1	3636	broad.mit.edu	37	11	71942214	71942214	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:71942214C>T	uc001osf.2	+	12	1625	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	INPPL1_uc001osg.2_Missense_Mutation_p.T251M	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	493					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						AAGGAGCTTACGGATCTGGAT	0.592000													12	196					0	0	0	0
GRIK4	2900	broad.mit.edu	37	11	120776051	120776051	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:120776051A>G	uc001pxn.2	+	13	1612	c.1325A>G	c.(1324-1326)GAC>GGC	p.D442G	GRIK4_uc009zav.1_Missense_Mutation_p.D442G|GRIK4_uc009zaw.1_Missense_Mutation_p.D442G|GRIK4_uc009zax.1_Missense_Mutation_p.D442G	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	442	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GAAGGCAATGACCGCTACGAG	0.537000													62	93					0	0	0	0
TECTA	7007	broad.mit.edu	37	11	121008284	121008284	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:121008284G>A	uc010rzo.1	+	10	3096	c.3096G>A	c.(3094-3096)ACG>ACA	p.T1032T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1032	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGTGTGTCACGCGGAGTGAGT	0.577000													30	24					0	0	0	0
OR8B8	26493	broad.mit.edu	37	11	124310617	124310617	+	Missense_Mutation	SNP	C	T	T	rs144609364	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:124310617C>T	uc010sal.1	-	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGCCACATAGCGGTCATACGC	0.488000													6	24					0	0	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709340	128709340	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:128709340G>A	uc001qeo.1	-	2	907	c.856C>T	c.(856-858)CTT>TTT	p.L286F	KCNJ1_uc001qep.1_Missense_Mutation_p.L267F|KCNJ1_uc001qeq.1_Missense_Mutation_p.L267F|KCNJ1_uc001qer.1_Missense_Mutation_p.L267F|KCNJ1_uc001qes.1_Missense_Mutation_p.L267F	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	286	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TGCTGGAGAAGGGTCTCCGCT	0.478000													14	40					0	0	0	0
AKAP3	10566	broad.mit.edu	37	12	4737262	4737262	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:4737262C>T	uc001qnb.3	-	4	1035	c.806G>A	c.(805-807)CGA>CAA	p.R269Q		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	269					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TTCCTGCCCTCGAAACCTCTT	0.443000													50	43					0	0	0	0
GALNT8	26290	broad.mit.edu	37	12	4835920	4835920	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:4835920G>A	uc001qne.1	+	2	526	c.434G>A	c.(433-435)CGG>CAG	p.R145Q		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	145	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GACCTCTTCCGGAAGTTTGGT	0.562000													16	50					0	0	0	0
MANSC1	54682	broad.mit.edu	37	12	12483418	12483418	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:12483418G>A	uc001rai.1	-	4	1097	c.839C>T	c.(838-840)ACG>ATG	p.T280M	MANSC1_uc010shm.1_Missense_Mutation_p.T214M|MANSC1_uc001raj.1_Missense_Mutation_p.T246M|MANSC1_uc009zht.1_Missense_Mutation_p.T199M	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	280	Thr-rich.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AATGAGGGTCGTGGGAGGCTG	0.547000													31	31					0	0	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028240	21028240	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:21028240C>A	uc001rek.2	+	8	925	c.799C>A	c.(799-801)CTA>ATA	p.L267I	SLCO1B3_uc001rel.2_Missense_Mutation_p.L267I|SLCO1B3_uc010sil.1_Missense_Mutation_p.L267I|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.L92I	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	267	Helical; Name=6; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGTGTCTGGACTATTTTCCAT	0.378000													24	191					2.39556e-15	2.62739e-15	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30881780	30881780	+	Silent	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:30881780T>C	uc001rji.1	-	8	2335	c.1584A>G	c.(1582-1584)TCA>TCG	p.S528S	CAPRIN2_uc001rjf.1_Silent_p.S325S|CAPRIN2_uc001rjg.1_Silent_p.S195S|CAPRIN2_uc001rjh.1_Silent_p.S528S|CAPRIN2_uc001rjj.1_Silent_p.S195S|CAPRIN2_uc001rjk.3_Silent_p.S528S|CAPRIN2_uc001rjl.3_Silent_p.S528S|CAPRIN2_uc001rjm.1_Silent_p.S195S|CAPRIN2_uc001rjn.1_Silent_p.S195S	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	528					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAGTGGTCCATGACTTGGTGG	0.453000													84	236					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40681307	40681307	+	Silent	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:40681307T>C	uc001rmg.3	+	20	2776	c.2655T>C	c.(2653-2655)AGT>AGC	p.S885S	LRRK2_uc001rmh.1_Silent_p.S507S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	885					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTATGGACAGTGTGTTTGCTC	0.373000													6	36					0	0	0	0
KRT81	3887	broad.mit.edu	37	12	52685196	52685196	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:52685196G>A	uc001sab.2	-	1	104	c.54C>T	c.(52-54)TGC>TGT	p.C18C	KRT86_uc010snq.1_Intron|KRT86_uc009zmg.2_Intron|KRT81_uc001sac.2_Intron	NM_002281	NP_002272	Q14533	KRT81_HUMAN	keratin, hair, basic, 1	18	Head.					keratin filament	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCGCGGCCCGCAGGCCGAGA	0.692000													10	9					0	0	0	0
PCBP2	5094	broad.mit.edu	37	12	53849719	53849719	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:53849719C>T	uc001sdl.3	+	5	527	c.177C>T	c.(175-177)ATC>ATT	p.I59I	PCBP2_uc001sdc.3_Silent_p.I59I|PCBP2_uc001sdb.3_Silent_p.I59I|PCBP2_uc001sde.3_Silent_p.I59I|PCBP2_uc001sdi.3_Silent_p.I59I|PCBP2_uc001sdd.3_Silent_p.I59I|PCBP2_uc001sdf.3_Silent_p.I59I|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Silent_p.I59I|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	59	KH 1.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						AGAGAATTATCACTTTGGCTG	0.403000													47	137					0	0	0	0
ITGA5	3678	broad.mit.edu	37	12	54797970	54797970	+	Silent	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:54797970T>A	uc001sga.2	-	15	1592	c.1524A>T	c.(1522-1524)CCA>CCT	p.P508P		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	508	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						TCCGCTCCTCTGGGTTGAACA	0.612000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	48					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57588203	57588203	+	Missense_Mutation	SNP	G	T	T	rs146710883	by1000genomes	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:57588203G>T	uc001snd.2	+	49	8451	c.7985G>T	c.(7984-7986)CGG>CTG	p.R2662L	MIR1228_hsa-mir-1228|MI0006318_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2662	LDL-receptor class A 14.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCTGCGAGCGGACCTCACTC	0.662000													61	71					1.53716e-24	1.76168e-24	1	0
PTPRB	5787	broad.mit.edu	37	12	70954686	70954686	+	Silent	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:70954686C>A	uc001swb.3	-	15	3573	c.3543G>T	c.(3541-3543)GGG>GGT	p.G1181G	PTPRB_uc010sto.1_Silent_p.G1091G|PTPRB_uc010stp.1_Silent_p.G1091G|PTPRB_uc001swc.3_Silent_p.G1399G|PTPRB_uc001swa.3_Silent_p.G1311G|PTPRB_uc001swd.3_Silent_p.G1398G|PTPRB_uc009zrr.1_Silent_p.G1278G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1181	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCCGATTGGACCCCCTGAGAT	0.458000													23	63					2.44723e-14	2.65551e-14	1	0
TRHDE	29953	broad.mit.edu	37	12	72866930	72866930	+	Silent	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:72866930T>C	uc001sxa.2	+	5	1449	c.1419T>C	c.(1417-1419)GGT>GGC	p.G473G		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	473	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AATTTGTTGGTACAGACTACC	0.423000													37	36					0	0	0	0
PAH	5053	broad.mit.edu	37	12	103248914	103248914	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:103248914T>A	uc001tjq.1	-	7	1178	c.706A>T	c.(706-708)ACT>TCT	p.T236S	PAH_uc010swc.1_Missense_Mutation_p.S236C	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	236					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GTGGACTTACTCTGCAGGAAC	0.468000													15	22					0	0	0	0
TBX3	6926	broad.mit.edu	37	12	115109730	115109730	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:115109730C>T	uc001tvt.1	-	8	3112	c.2148G>A	c.(2146-2148)GCG>GCA	p.A716A	TBX3_uc001tvu.1_Silent_p.A696A	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	716					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGCTGGTGGCCGCCTCTTTCT	0.652000													4	5					0	0	0	0
RFC5	5985	broad.mit.edu	37	12	118456893	118456893	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:118456893C>A	uc001twq.2	+	2	207	c.82C>A	c.(82-84)CCA>ACA	p.P28T	RFC5_uc010syx.1_Missense_Mutation_p.P7T|RFC5_uc010syy.1_Missense_Mutation_p.P7T|RFC5_uc010syz.1_5'UTR|RFC5_uc009zwr.2_Missense_Mutation_p.P28T	NM_007370	NP_031396	P40937	RFC5_HUMAN	replication factor C 5 isoform 1	28					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAAATACCGGCCACAGACCCT	0.338000													25	38					1.1804e-14	1.28771e-14	1	0
SACS	26278	broad.mit.edu	37	13	23905170	23905170	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:23905170C>G	uc001uon.2	-	10	13434	c.12845G>C	c.(12844-12846)GGT>GCT	p.G4282A	SACS_uc001uoo.2_Missense_Mutation_p.G4135A|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4282					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCTCTCTCTACCAGAGAAAAG	0.478000													44	37					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23915744	23915744	+	Silent	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:23915744G>C	uc001uon.2	-	10	2860	c.2271C>G	c.(2269-2271)GGC>GGG	p.G757G	SACS_uc001uoo.2_Silent_p.G610G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Silent_p.G610G	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	757					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCAATTCTCTGCCAGGCCAGA	0.363000													14	73					0	0	0	0
KLF12	11278	broad.mit.edu	37	13	74420023	74420023	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:74420023C>G	uc001vjf.2	-	4	833	c.611G>C	c.(610-612)GGA>GCA	p.G204A	KLF12_uc010aeq.2_Missense_Mutation_p.G204A|KLF12_uc001vjg.3_Missense_Mutation_p.G204A	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	204					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		GTTCACATTTCCAGGTGACCT	0.468000													26	34					0	0	0	0
LMO7	4008	broad.mit.edu	37	13	76395471	76395471	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:76395471A>G	uc001vjv.2	+	11	2427	c.1667A>G	c.(1666-1668)GAA>GGA	p.E556G	LMO7_uc010thv.1_Missense_Mutation_p.E507G|LMO7_uc001vjt.1_Missense_Mutation_p.E455G|LMO7_uc010thw.1_Missense_Mutation_p.E406G|LMO7_uc001vjw.1_Missense_Mutation_p.E462G	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	841						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TATCCTTCAGAAATTCCCAAA	0.448000													12	37					0	0	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485361	97485361	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:97485361G>A	uc001vmw.2	+	2	1349	c.1325G>A	c.(1324-1326)CGA>CAA	p.R442Q		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	442	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					AGGCTGCAGCGAGAGCACAGG	0.612000													18	32					0	0	0	0
OR4K15	81127	broad.mit.edu	37	14	20444015	20444015	+	Missense_Mutation	SNP	G	A	A	rs139377821	by1000genomes	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:20444015G>A	uc010tkx.1	+	1	338	c.338G>A	c.(337-339)CGC>CAC	p.R113H		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	113	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGGTTGAGCGCAAGACTATT	0.453000													36	41					0	0	0	0
PCK2	5106	broad.mit.edu	37	14	24572812	24572812	+	Missense_Mutation	SNP	G	A	A	rs35618680	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:24572812G>A	uc001wlt.2	+	10	1694	c.1562G>A	c.(1561-1563)CGC>CAC	p.R521H	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Intron|PCK2_uc010tnw.1_Missense_Mutation_p.R387H|PCK2_uc010tnx.1_Missense_Mutation_p.R387H|PCK2_uc001wlu.3_Missense_Mutation_p.R355H	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	521					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity	p.R521H(1)		ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		ATGGAAGGGCGCAAGGGGGCC	0.607000													5	45					0	0	0	0
SPTB	6710	broad.mit.edu	37	14	65260353	65260353	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:65260353C>T	uc001xht.2	-	13	2082	c.2028G>A	c.(2026-2028)CAG>CAA	p.Q676Q	SPTB_uc001xhr.2_Silent_p.Q676Q|SPTB_uc001xhs.2_Silent_p.Q676Q|SPTB_uc001xhu.2_Silent_p.Q676Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	676	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTGCTTGCGCTGTAAGATGA	0.547000													19	20					0	0	0	0
COX16	51241	broad.mit.edu	37	14	70795912	70795912	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:70795912T>C	uc001xmb.2	-	3	323	c.183A>G	c.(181-183)ATA>ATG	p.I61M		NM_016468	NP_057552	Q9P0S2	COX16_HUMAN	COX16 cytochrome c oxidase assembly homolog	61						integral to membrane|mitochondrial membrane					0						ACTCTAAAGATATTTTATTCT	0.303000													8	17					0	0	0	0
BATF	10538	broad.mit.edu	37	14	76012935	76012935	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:76012935C>T	uc001xrr.2	+	3	541	c.299C>T	c.(298-300)ACG>ATG	p.T100M		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	100						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		GCCGCCAGCACGCCCTCGCCC	0.642000													8	9					0	0	0	0
TC2N	123036	broad.mit.edu	37	14	92249476	92249476	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:92249476C>T	uc001xzu.3	-	12	1632	c.1441G>A	c.(1441-1443)GTT>ATT	p.V481I	TC2N_uc001xzt.3_Missense_Mutation_p.V481I|TC2N_uc010auc.2_Missense_Mutation_p.V417I|TC2N_uc001xzv.3_Missense_Mutation_p.V481I	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	481						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CACCTGATAACAACCTTTTCT	0.328000													32	113					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088956	94088956	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:94088956G>C	uc001ybv.1	+	28	4995	c.4912G>C	c.(4912-4914)GAT>CAT	p.D1638H	KIAA1409_uc001ybs.1_Missense_Mutation_p.D1616H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1793						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AGTTCCCGAAGATGCAGAGAA	0.542000													25	41					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	107160069	107160069	+	Splice_Site	SNP	A	G	G	rs6576212	by1000genomes	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:107160069A>G	uc010tyt.1	-	40		c.2938_splice	c.e40+1							Parts of antibodies, mostly variable regions.												0						AGGAGCAGCAAGTGAAGGTGT	0.537000													5	66					0	0	0	0
GOLGA8C	729786	broad.mit.edu	37	15	20778004	20778004	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:20778004G>T	uc010tzc.1	+	18	2260	c.1245G>T	c.(1243-1245)TTG>TTT	p.L415F	uc001ytq.2_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E											skin(1)	1						ACCCAGGCTTGGGCAGCAACT	0.547000													24	24					4.22769e-11	4.53921e-11	1	0
HERC2	8924	broad.mit.edu	37	15	28419625	28419625	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:28419625T>G	uc001zbj.2	-	65	10079	c.9973A>C	c.(9973-9975)ACA>CCA	p.T3325P		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3325	RCC1 12.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCCACAGTTGTCCACGCCACA	0.557000													14	29					0	0	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439887	42439887	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:42439887C>T	uc001zoz.2	-	12	1196	c.1133G>A	c.(1132-1134)GGG>GAG	p.G378E	PLA2G4F_uc010bcq.2_5'Flank|PLA2G4F_uc001zoy.2_Missense_Mutation_p.G10E|PLA2G4F_uc010bcr.2_Missense_Mutation_p.G129E|PLA2G4F_uc001zpa.2_Missense_Mutation_p.G129E|PLA2G4F_uc010bcs.2_Missense_Mutation_p.G165E	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	378	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTCCTGCAACCCTGCCAGGCT	0.577000													27	76					0	0	0	0
ATP8B4	79895	broad.mit.edu	37	15	50211036	50211036	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:50211036C>A	uc001zxu.2	-	19	2177	c.2035G>T	c.(2035-2037)GAA>TAA	p.E679*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.E552*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.E489*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	679	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCAAGTTACCTTGTTTGTCT	0.318000													15	56					1.15088e-07	1.20399e-07	1	0
IL16	3603	broad.mit.edu	37	15	81591957	81591957	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:81591957G>A	uc002bgh.3	+	14	2666	c.2290G>A	c.(2290-2292)GCC>ACC	p.A764T	IL16_uc010blq.1_Missense_Mutation_p.A718T|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.A806T|IL16_uc002bgg.2_Missense_Mutation_p.A764T|IL16_uc002bgi.1_Missense_Mutation_p.A154T|IL16_uc002bgj.2_Missense_Mutation_p.A258T|IL16_uc002bgk.2_Missense_Mutation_p.A63T|IL16_uc002bgl.1_Missense_Mutation_p.A63T|IL16_uc010unq.1_Missense_Mutation_p.A63T	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	764					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GCTGGACACCGCCAATGGCAC	0.557000													30	22					0	0	0	0
TMEM8A	58986	broad.mit.edu	37	16	424221	424221	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:424221C>T	uc002cgu.3	-	10	1884	c.1755G>A	c.(1753-1755)ACG>ACA	p.T585T	TMEM8A_uc002cgv.3_Silent_p.T392T	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	585	Helical; (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						GCCAGCCTACCGTGGAGAAGA	0.662000											OREG0003702	type=REGULATORY REGION|Gene=TMEM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	34					0	0	0	0
NOXO1	124056	broad.mit.edu	37	16	2031220	2031220	+	5'Flank	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:2031220G>T	uc002cnx.2	-						NOXO1_uc002cnz.2_5'UTR|NOXO1_uc002coa.2_5'UTR|NOXO1_uc002cny.2_5'Flank|GFER_uc002cob.2_5'Flank	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c						cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						AAATGGGCGAGGACCCTTCTG	0.617000													13	21					1.3612e-06	1.40957e-06	1	0
CARHSP1	23589	broad.mit.edu	37	16	8952230	8952230	+	Silent	SNP	G	A	A	rs141833541	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:8952230G>A	uc002czh.1	-	3	608	c.258C>T	c.(256-258)CCC>CCT	p.P86P	PMM2_uc002czg.1_Intron|CARHSP1_uc002czi.1_Silent_p.P86P	NM_001042476	NP_001035941	Q9Y2V2	CHSP1_HUMAN	calcium-regulated heat-stable protein 1	86	CSD.				intracellular signal transduction|regulation of mRNA stability|regulation of transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|P granule	DNA binding|mRNA 3'-UTR binding|phosphatase binding				0						GGAAGATGTCGGGGCCGCCAT	0.632000													10	21					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570634	20570634	+	Missense_Mutation	SNP	G	A	A	rs141121285		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:20570634G>A	uc002dhj.3	-	4	523	c.313C>T	c.(313-315)CGT>TGT	p.R105C	ACSM2B_uc002dhk.3_Missense_Mutation_p.R105C|ACSM2B_uc010bwf.1_Missense_Mutation_p.R105C	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	105					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CGATCCCCACGCTGCAGGCCA	0.567000													16	18					0	0	0	0
IL21R	50615	broad.mit.edu	37	16	27460487	27460487	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:27460487C>A	uc002doq.1	+	9	1733	c.1500C>A	c.(1498-1500)AGC>AGA	p.S500R	IL21R_uc002dor.1_Missense_Mutation_p.S500R|IL21R_uc002dos.1_Missense_Mutation_p.S500R|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	500	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CTGACTGCAGCAGCCCTGTGG	0.657000			T	BCL6	NHL								16	59					4.7546e-09	5.05177e-09	1	0
CNOT1	23019	broad.mit.edu	37	16	58571071	58571071	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:58571071C>T	uc002env.2	-	39	5761	c.5468G>A	c.(5467-5469)CGT>CAT	p.R1823H	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.R1818H|CNOT1_uc010vik.1_Missense_Mutation_p.R780H	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1823					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TCCATGAGCACGATCAATCAT	0.468000													9	95					0	0	0	0
LRRC36	55282	broad.mit.edu	37	16	67409205	67409205	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:67409205C>A	uc002esv.2	+	10	1569	c.1550C>A	c.(1549-1551)CCC>CAC	p.P517H	LRRC36_uc002esw.2_Intron|LRRC36_uc002esx.2_Missense_Mutation_p.P396H|LRRC36_uc010vjk.1_Intron|LRRC36_uc010vjl.1_Missense_Mutation_p.P38T|LRRC36_uc002esy.2_Missense_Mutation_p.P27H	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	517											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CACAGTCCCCCCATCTCTGCC	0.512000													111	194					9.1649e-64	1.06837e-63	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77327019	77327019	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:77327019C>A	uc002ffc.3	-	20	3562	c.3143G>T	c.(3142-3144)TGC>TTC	p.C1048F	ADAMTS18_uc010chc.1_Missense_Mutation_p.C636F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1048	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GTTCTTGGGGCATCGTCCAAG	0.507000													30	78					5.09552e-08	5.35818e-08	1	0
DLG4	1742	broad.mit.edu	37	17	7122262	7122262	+	Translation_Start_Site	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:7122262G>A	uc002get.3	-	1	1108	c.-93C>T	c.(-95--91)GACGG>GATGG		DLG4_uc010cly.2_5'Flank|DLG4_uc010vto.1_Translation_Start_Site|DLG4_uc002geu.2_5'Flank|ACADVL_uc010vtp.1_Intron|ACADVL_uc010vtq.1_5'Flank|ACADVL_uc002gev.2_5'Flank|ACADVL_uc002gew.2_5'Flank|ACADVL_uc002gex.2_5'Flank	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1						axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						AAAGTAGGCCGTCTCTGAGCC	0.567000													5	10					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578479	7578479	+	Missense_Mutation	SNP	G	A	A	rs28934874		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:7578479G>A	uc002gim.2	-	5	645	c.451C>T	c.(451-453)CCC>TCC	p.P151S	TP53_uc002gig.1_Missense_Mutation_p.P151S|TP53_uc002gih.2_Missense_Mutation_p.P151S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19S|TP53_uc010cng.1_Missense_Mutation_p.P19S|TP53_uc002gii.1_Missense_Mutation_p.P19S|TP53_uc010cnh.1_Missense_Mutation_p.P151S|TP53_uc010cni.1_Missense_Mutation_p.P151S|TP53_uc002gij.2_Missense_Mutation_p.P151S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58S|TP53_uc002gio.2_Missense_Mutation_p.P19S|TP53_uc010vug.1_Missense_Mutation_p.P112S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(10)|p.P152fs*18(9)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P58A(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P19A(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	21					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10368799	10368799	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:10368799G>A	uc002gmn.2	-	5	576	c.465C>T	c.(463-465)ATC>ATT	p.I155I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	155	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGATGGAGAAGATATGGGGTG	0.478000													54	107					0	0	0	0
ADAP2	55803	broad.mit.edu	37	17	29253865	29253865	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:29253865C>T	uc002hfx.2	+	3	525	c.246C>T	c.(244-246)AAC>AAT	p.N82N	ADAP2_uc010csk.2_Silent_p.N88N|ADAP2_uc002hfy.2_Silent_p.N82N|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	82	Arf-GAP.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						ACAATGGAAACCTCCGTGTGA	0.478000													21	41					0	0	0	0
SAMD14	201191	broad.mit.edu	37	17	48192980	48192980	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:48192980G>T	uc002iqg.2	-	7	1069	c.770C>A	c.(769-771)CCC>CAC	p.P257H	SAMD14_uc002iqd.2_Missense_Mutation_p.P40H|SAMD14_uc002iqe.2_Missense_Mutation_p.P40H|SAMD14_uc002iqf.2_Missense_Mutation_p.P257H	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	257											0						GGAGCAGGTGGGGGAGGTGGT	0.622000													52	118					9.55421e-19	1.07683e-18	1	0
RNF213	57674	broad.mit.edu	37	17	78355470	78355470	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:78355470G>A	uc002jyh.1	+	32	8363	c.8140G>A	c.(8140-8142)GTG>ATG	p.V2714M	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.V1096M	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GACCATCGGCGTGGTCCACCT	0.597000													7	32					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7050890	7050890	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:7050890G>A	uc002knm.2	-	4	485	c.391C>T	c.(391-393)CGA>TGA	p.R131*	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	131	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTCCAGGTCGAGGGGCATTG	0.423000													21	45					0	0	0	0
SETBP1	26040	broad.mit.edu	37	18	42532422	42532422	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:42532422C>G	uc010dni.2	+	4	3413	c.3117C>G	c.(3115-3117)AGC>AGG	p.S1039R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1039						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGGGTTCAGCTACCCTATTC	0.448000									Schinzel-Giedion_syndrome				12	34					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63481745	63481745	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:63481745C>T	uc002ljz.2	+	4	855	c.530C>T	c.(529-531)GCG>GTG	p.A177V	CDH7_uc002lka.2_Missense_Mutation_p.A177V|CDH7_uc002lkb.2_Missense_Mutation_p.A177V	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	177	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CAAGTGACAGCGACGGATGCT	0.438000													28	89					0	0	0	0
SLC39A3	29985	broad.mit.edu	37	19	2733161	2733161	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:2733161G>A	uc002lwg.2	-	3	787	c.533C>T	c.(532-534)TCG>TTG	p.S178L	SLC39A3_uc010xgy.1_Missense_Mutation_p.S178L	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	178	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAGTGGGCCGACAGCGCGAA	0.721000													18	47					0	0	0	0
MAP2K2	5605	broad.mit.edu	37	19	4117549	4117549	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:4117549A>C	uc002lzk.2	-	2	425	c.171T>G	c.(169-171)TTT>TTG	p.F57L		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	57			F -> C (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGGTGAGAAAGGCTTCCA	0.597000									Cardiofaciocutaneous_syndrome				28	46					0	0	0	0
DENND1C	79958	broad.mit.edu	37	19	6468392	6468392	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:6468392G>T	uc002mfe.2	-	22	1736	c.1644C>A	c.(1642-1644)AGC>AGA	p.S548R	DENND1C_uc002mfb.2_Missense_Mutation_p.S98R|DENND1C_uc002mfc.2_Missense_Mutation_p.S98R|DENND1C_uc002mfd.2_Missense_Mutation_p.S98R|DENND1C_uc010xje.1_Missense_Mutation_p.S504R	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	548						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CCAAGAAGCTGCTGTCCAGAG	0.587000													11	15					2.27111e-07	2.36381e-07	1	0
MUC16	94025	broad.mit.edu	37	19	9011414	9011414	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:9011414C>G	uc002mkp.2	-	36	39023	c.38819G>C	c.(38818-38820)AGA>ACA	p.R12940T	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12942	SEA 6.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGCTGCTCTCTGTTGAGTCC	0.577000													10	204					0	0	0	0
CPAMD8	27151	broad.mit.edu	37	19	17088276	17088276	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:17088276C>G	uc002nfb.2	-	15	1833	c.1801G>C	c.(1801-1803)GTC>CTC	p.V601L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	554						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCAAGGGGGACCATGCTGGGG	0.587000													13	34					0	0	0	0
ZNF569	148266	broad.mit.edu	37	19	37904369	37904369	+	Silent	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:37904369A>T	uc002ogi.2	-	6	1749	c.1191T>A	c.(1189-1191)CTT>CTA	p.L397L	ZNF569_uc002ogh.2_Silent_p.L238L|ZNF569_uc002ogj.2_Silent_p.L421L	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	397	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTACAGTAAGGGCTGAGC	0.383000													9	77					0	0	0	0
ZNF569	148266	broad.mit.edu	37	19	37917207	37917207	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:37917207C>T	uc002ogi.2	-	4	647	c.89G>A	c.(88-90)AGA>AAA	p.R30K	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Missense_Mutation_p.R54K	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTACAGTTTTCTCTGAGCAGG	0.388000													27	36					0	0	0	0
CYP2B6	1555	broad.mit.edu	37	19	41510326	41510326	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:41510326G>A	uc002opr.1	+	3	466	c.459G>A	c.(457-459)CTG>CTA	p.L153L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.L113L	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	153					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CTCAGTGTCTGATAGAGGAGC	0.517000													13	13					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43433689	43433689	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:43433689A>T	uc002ovl.3	-	4	716	c.614T>A	c.(613-615)TTT>TAT	p.F205Y	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.F24Y|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.F83Y	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	205	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TGTGACACCAAATAGGTAGAG	0.522000													151	242					0	0	0	0
ZNF549	256051	broad.mit.edu	37	19	58049113	58049114	+	Nonsense_Mutation	DNP	TA	AG	AG			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:58049113_58049114TA>AG	uc002qpb.1	+	4	990_991	c.741_742TA>AG	c.(739-744)TATAAG>TAAGAG	p.247_248YK>*E	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Nonsense_Mutation_p.234_235YK>*E	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	247_248	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAAAGCTTATAAGCGTAGGGA	0.386000													26	58					0	0	0	0
NLRC4	58484	broad.mit.edu	37	2	32476104	32476104	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:32476104C>T	uc002roi.2	-	4	1075	c.829G>A	c.(829-831)GTC>ATC	p.V277I	NLRC4_uc002roj.1_Missense_Mutation_p.V277I|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	277	LRR 2.|NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GTAGTGGTGACGATGACCATG	0.522000													54	88					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33500893	33500893	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:33500893C>G	uc002ros.2	+	18	2898	c.2898C>G	c.(2896-2898)GAC>GAG	p.D966E	LTBP1_uc002rot.2_Missense_Mutation_p.D640E|LTBP1_uc002rou.2_Missense_Mutation_p.D639E|LTBP1_uc002rov.2_Missense_Mutation_p.D586E|LTBP1_uc010ymz.1_Missense_Mutation_p.D639E|LTBP1_uc010yna.1_Missense_Mutation_p.D586E	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	965	EGF-like 6; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGAGGCCGGACGTCTGTGGGG	0.532000													32	134					0	0	0	0
MTA3	57504	broad.mit.edu	37	2	42836652	42836652	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:42836652A>G	uc002rso.1	+	5	747	c.77A>G	c.(76-78)CAG>CGG	p.Q26R	MTA3_uc002rsp.1_Missense_Mutation_p.Q26R|MTA3_uc002rsq.2_Missense_Mutation_p.Q82R|MTA3_uc002rsr.2_Missense_Mutation_p.Q82R	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	82	BAH.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACCGATAAGCAGAAACATCAG	0.358000													8	95					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	50318532	50318532	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:50318532C>T	uc010fbp.2	-	3	1349	c.542G>A	c.(541-543)CGT>CAT	p.R181H	NRXN1_uc002rxb.3_Missense_Mutation_p.R888H|NRXN1_uc010fbq.2_Missense_Mutation_p.R1256H|NRXN1_uc002rxe.3_Missense_Mutation_p.R1216H	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	181	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCTCGTGAAACGAACTACATG	0.473000													69	193					0	0	0	0
XPO1	7514	broad.mit.edu	37	2	61719576	61719576	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:61719576T>G	uc002sbj.2	-	15	2335	c.1607A>C	c.(1606-1608)AAT>ACT	p.N536T	XPO1_uc010fcl.2_Missense_Mutation_p.N532T|XPO1_uc010ypn.1_Missense_Mutation_p.N532T|XPO1_uc002sbk.2_Missense_Mutation_p.N97T|XPO1_uc002sbh.2_Missense_Mutation_p.N183T	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	536	Necessary for HTLV-1 Rex-mediated mRNA export.|HEAT 4.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AATAGCTTTATTATCTTTGCC	0.299000													7	40					0	0	0	0
SNRNP200	23020	broad.mit.edu	37	2	96970578	96970578	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:96970578C>T	uc002svu.2	-	2	160	c.74G>A	c.(73-75)CGT>CAT	p.R25H		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	25						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						AATGAGAGAACGGTCAGCTTG	0.522000													11	31					0	0	0	0
C2orf40	84417	broad.mit.edu	37	2	106690370	106690370	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:106690370C>T	uc010fjf.2	+	3	264	c.156C>T	c.(154-156)GCC>GCT	p.A52A		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	52						extracellular region|transport vesicle					0						CTAAAGTGGCCGTTGATGAGA	0.527000													66	116					0	0	0	0
UBXN4	23190	broad.mit.edu	37	2	136528287	136528287	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:136528287A>G	uc002tur.2	+	8	1115	c.804A>G	c.(802-804)ATA>ATG	p.I268M	UBXN4_uc002tus.2_Missense_Mutation_p.I34M	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	268	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						GAGAACGTATAAAACAGCAGA	0.373000													13	14					0	0	0	0
C2orf77	129881	broad.mit.edu	37	2	170510628	170510628	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:170510628G>A	uc002ufe.2	-	6	1010	c.916C>T	c.(916-918)CGT>TGT	p.R306C		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	306	Potential.										0						TGTATAAGACGCTTTTTTGCT	0.323000													6	12					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179616133	179616133	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:179616133G>A	uc002unb.2	-	46	11218	c.10994C>T	c.(10993-10995)GCC>GTC	p.A3665V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTTCTTGGCAGAACTCAT	0.363000													176	45					0	0	0	0
INO80D	54891	broad.mit.edu	37	2	206869901	206869901	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:206869901G>A	uc002vaz.3	-	11	2680	c.2275C>T	c.(2275-2277)CCA>TCA	p.P759S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	759					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ACGTTGGCTGGGGCAGAGAAC	0.557000													25	39					0	0	0	0
SLC4A3	6508	broad.mit.edu	37	2	220501041	220501041	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:220501041C>A	uc002vmp.3	+	15	2478	c.2209C>A	c.(2209-2211)CTG>ATG	p.L737M	SLC4A3_uc002vmo.3_Missense_Mutation_p.L764M|SLC4A3_uc010fwm.2_Missense_Mutation_p.L287M|SLC4A3_uc010fwn.1_Missense_Mutation_p.L246M	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	737	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACCGAGGGGCTGATGGGCGT	0.617000													46	31					1.35964e-18	1.52236e-18	1	0
NKX2-2	4821	broad.mit.edu	37	20	21492699	21492699	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:21492699G>T	uc002wsi.2	-	2	1041	c.684C>A	c.(682-684)TTC>TTA	p.F228L		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	228					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						TGCCCGCCTGGAAGGTGGCGG	0.682000													27	42					1.16021e-09	1.23918e-09	1	0
NDRG3	57446	broad.mit.edu	37	20	35317165	35317165	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:35317165T>C	uc002xfw.2	-	4	198	c.116A>G	c.(115-117)CAT>CGT	p.H39R	NDRG3_uc002xfx.2_Missense_Mutation_p.H27R|NDRG3_uc010zvq.1_Intron|NDRG3_uc010zvr.1_Intron	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	39					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				GACCACACCATGAGTTGTTTC	0.378000													8	118					0	0	0	0
SRC	6714	broad.mit.edu	37	20	36024685	36024685	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:36024685G>T	uc002xgx.2	+	8	1123	c.674G>T	c.(673-675)AGC>ATC	p.S225I	SRC_uc002xgy.2_Missense_Mutation_p.S225I	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	225	SH2.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CAGTTCAACAGCCTGCAGCAG	0.637000													9	68					1.76689e-08	1.8676e-08	1	0
TP53RK	112858	broad.mit.edu	37	20	45315483	45315483	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:45315483C>G	uc002xsk.2	-	2	894	c.671G>C	c.(670-672)AGC>ACC	p.S224T	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_3'UTR	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	224	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				GGTGGAGTAGCTCTTCAGAAA	0.488000													44	80					0	0	0	0
PREX1	57580	broad.mit.edu	37	20	47266017	47266017	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:47266017G>A	uc002xtw.1	-	25	3149	c.3126C>T	c.(3124-3126)GGC>GGT	p.G1042G	PREX1_uc002xtv.1_Silent_p.G339G	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1042					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGAGACCCTGGCCTTGGGGAT	0.627000													20	31					0	0	0	0
CDH4	1002	broad.mit.edu	37	20	60485513	60485513	+	Silent	SNP	C	T	T	rs148334531		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:60485513C>T	uc002ybn.1	+	9	1238	c.1224C>T	c.(1222-1224)ACC>ACT	p.T408T	CDH4_uc002ybp.1_Silent_p.T334T	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	408	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCGTGGAGACCGTGGTCGCAA	0.478000													18	15					0	0	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737451	62737451	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:62737451C>T	uc011abt.1	-	1	734	c.734G>A	c.(733-735)CGC>CAC	p.R245H		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	245	Cytoplasmic (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					GGCTCCAGAGCGGAGCCGCAC	0.667000													9	13					0	0	0	0
DIP2A	23181	broad.mit.edu	37	21	47971553	47971553	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr21:47971553G>T	uc002zjo.2	+	24	3029	c.2846G>T	c.(2845-2847)GGA>GTA	p.G949V	DIP2A_uc011afy.1_Missense_Mutation_p.G885V|DIP2A_uc011afz.1_Missense_Mutation_p.G945V	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	949					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTAGAGGTTGGACCAGCCTCA	0.478000													13	7					9.05144e-12	9.76981e-12	1	0
Unknown	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr22:18844763T>C	uc002zoe.2	+	4		c.2017T>C			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		TCACAGCCTCTGAGGGCAGCA	0.562000													3	21					0	0	0	0
LOC96610	96610	broad.mit.edu	37	22	23101561	23101561	+	RNA	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr22:23101561T>G	uc011aim.1	+	210		c.10990T>G								Parts of antibodies, mostly variable regions.												0						ATTTATGAGGTCAGTAATCGG	0.547000													67	236					0	0	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr22:24659734T>C	uc002zzs.3	+	7		c.3466T>C			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						CTCTCTCCTGTGGGAGGGGGG	0.632000													5	25					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50728272	50728272	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr22:50728272G>A	uc003bkv.3	-	3	848	c.742C>T	c.(742-744)CGC>TGC	p.R248C		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	248	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTGCACATGCGTGCCAGCAGC	0.637000													39	42					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53700400	53700400	+	Silent	SNP	G	A	A	rs147336902	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:53700400G>A	uc003dgv.3	+	7	1117	c.954G>A	c.(952-954)GCG>GCA	p.A318A	CACNA1D_uc003dgu.3_Silent_p.A318A|CACNA1D_uc003dgy.3_Silent_p.A318A|CACNA1D_uc003dgw.3_5'UTR	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	318	Extracellular (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CTCCATGTGCGTTCTCAGGGA	0.532000													8	126					0	0	0	0
KLF15	28999	broad.mit.edu	37	3	126062647	126062647	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:126062647G>A	uc011bkk.1	-	3	1356	c.1174C>T	c.(1174-1176)CGG>TGG	p.R392W		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	392	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		TGGTCGCTCCGCGCGAACTTC	0.652000													10	22					0	0	0	0
ZIC4	84107	broad.mit.edu	37	3	147114186	147114186	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:147114186G>A	uc003ewd.1	-	3	414	c.141C>T	c.(139-141)CAC>CAT	p.H47H	ZIC4_uc003ewc.1_Translation_Start_Site|ZIC4_uc011bno.1_Silent_p.H97H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	47						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GAGGCTCCTCGTGGAGGCCCG	0.672000													14	25					0	0	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716163	170716163	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:170716163T>A	uc003fhe.1	-	10	1502	c.1193A>T	c.(1192-1194)TAT>TTT	p.Y398F	SLC2A2_uc003fhf.1_Missense_Mutation_p.Y225F|SLC2A2_uc011bpu.1_Missense_Mutation_p.Y271F	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	398	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CATGCTCACATAACTCATCCA	0.433000													15	23					0	0	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716165	170716165	+	Silent	SNP	A	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:170716165A>G	uc003fhe.1	-	10	1500	c.1191T>C	c.(1189-1191)AGT>AGC	p.S397S	SLC2A2_uc003fhf.1_Silent_p.S224S|SLC2A2_uc011bpu.1_Silent_p.S270S	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	397	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TGCTCACATAACTCATCCAAG	0.433000													13	21					0	0	0	0
STK32B	55351	broad.mit.edu	37	4	5170173	5170173	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:5170173C>A	uc003gih.1	+	3	320	c.256C>A	c.(256-258)CTG>ATG	p.L86M	STK32B_uc010ida.1_Missense_Mutation_p.L39M	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	86	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CCTGGTCAATCTGTGGTGAGT	0.552000													6	13					3.59834e-05	3.70738e-05	1	0
KIAA1211	57482	broad.mit.edu	37	4	57182512	57182512	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:57182512C>T	uc003hbk.2	+	8	3235	c.2844C>T	c.(2842-2844)CAC>CAT	p.H948H	KIAA1211_uc010iha.2_Silent_p.H941H|KIAA1211_uc011bzz.1_Silent_p.H858H|KIAA1211_uc003hbm.1_Silent_p.H834H	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	948	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTCCGGAGCACGACAAGGCAG	0.642000													9	23					0	0	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82369372	82369372	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:82369372G>A	uc003hmi.1	-	5	649	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	RASGEF1B_uc003hmj.1_Nonsense_Mutation_p.Q168*|RASGEF1B_uc010ijq.1_Nonsense_Mutation_p.Q127*	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	169					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						TCTTCGTACTGGCTGAGCGCA	0.463000													76	105					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115891710	115891710	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:115891710A>T	uc003ibu.2	-	4	1776	c.1097T>A	c.(1096-1098)CTT>CAT	p.L366H	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	366	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCGAAGTAAAAGGTCATCTCC	0.393000													17	17					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247244	153247244	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:153247244C>G	uc003ims.2	-	10	1707	c.1558G>C	c.(1558-1560)GAT>CAT	p.D520H	FBXW7_uc011cii.1_Missense_Mutation_p.D520H|FBXW7_uc003imt.2_Missense_Mutation_p.D520H|FBXW7_uc011cih.1_Missense_Mutation_p.D344H|FBXW7_uc003imq.2_Missense_Mutation_p.D440H|FBXW7_uc003imr.2_Missense_Mutation_p.D402H	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	520	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.D520N(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACCATAAAATCATATGCTCCA	0.433000			Mis|N|D|F		colorectal|endometrial|T-ALL								102	35					0	0	0	0
PLRG1	5356	broad.mit.edu	37	4	155459166	155459166	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:155459166T>C	uc003iny.2	-	13	1309	c.1246A>G	c.(1246-1248)ATT>GTT	p.I416V	PLRG1_uc003inz.2_Missense_Mutation_p.I407V	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	416	WD 6.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				AATGTGTTAATAATAGCATTA	0.308000													50	17					0	0	0	0
GRIA2	2891	broad.mit.edu	37	4	158254041	158254041	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:158254041G>T	uc003ipm.3	+	7	1412	c.953G>T	c.(952-954)AGA>ATA	p.R318I	GRIA2_uc011cit.1_Missense_Mutation_p.R271I|GRIA2_uc003ipl.3_Missense_Mutation_p.R318I|GRIA2_uc003ipk.3_Missense_Mutation_p.R271I|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	318	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGGAAGCAAAGAATTGAAATC	0.483000													26	39					9.78306e-22	1.11494e-21	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5319209	5319209	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:5319209C>T	uc003jdl.2	+	23	3771	c.3633C>T	c.(3631-3633)TAC>TAT	p.Y1211Y		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1211	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ACAAGTTCTACGGCAAGCAGT	0.522000													7	7					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9050539	9050539	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:9050539T>C	uc003jek.2	-	21	3588	c.2876A>G	c.(2875-2877)GAA>GGA	p.E959G		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	959	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCTTTTCTCTTCTACGCTACT	0.363000													14	31					0	0	0	0
PDE4D	5144	broad.mit.edu	37	5	59284494	59284494	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:59284494G>A	uc003jsb.2	-	3	306	c.93C>T	c.(91-93)CGC>CGT	p.R31R	PDE4D_uc010iwj.1_Silent_p.R31R|PDE4D_uc003jse.1_Silent_p.R43R	NM_006203	NP_006194	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 2	Error:Variant_position_missing_in_Q08499_after_alignment					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GTTCCATTCCGCGGAAAGGGT	0.428000													38	30					0	0	0	0
C5orf44	80006	broad.mit.edu	37	5	64946652	64946652	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:64946652G>A	uc003jtz.3	+	6	774	c.444G>A	c.(442-444)GTG>GTA	p.V148V	C5orf44_uc003jua.3_Silent_p.V148V|C5orf44_uc003juc.3_Silent_p.V148V|C5orf44_uc010iwv.2_Silent_p.V148V	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	148										ovary(1)	1						TATGTGCTGTGAGTTATACAA	0.289000													15	7					0	0	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176805	140176805	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:140176805G>T	uc003lhd.2	+	1	2362	c.2256G>T	c.(2254-2256)CAG>CAT	p.Q752H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.Q752H|PCDHA2_uc011czy.1_Missense_Mutation_p.Q752H	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	752	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTACTCGCAGCAGAGGCGGC	0.672000													38	30					1.30998e-17	1.45237e-17	1	0
KCNMB1	3779	broad.mit.edu	37	5	169805970	169805970	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:169805970T>A	uc003maq.1	-	4	714	c.314A>T	c.(313-315)TAC>TTC	p.Y105F	KCNIP1_uc003map.2_Intron	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	105	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		GCCTGGGATGTAGGAGCACTG	0.478000													18	17					0	0	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139206	178139206	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:178139206G>C	uc003mjj.2	-	5	1871	c.1673C>G	c.(1672-1674)ACT>AGT	p.T558S		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	558	C2H2-type 12.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TTGTCTAAAAGTTTTTCCACA	0.373000													30	25					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38862507	38862507	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:38862507C>T	uc003ooe.1	+	57	8563	c.7963C>T	c.(7963-7965)CAT>TAT	p.H2655Y		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCTAAATTTCATTACATCTT	0.363000													19	10					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38890944	38890944	+	Missense_Mutation	SNP	C	G	G	rs147574550	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:38890944C>G	uc003ooe.1	+	70	10722	c.10122C>G	c.(10120-10122)TTC>TTG	p.F3374L	uc003oof.1_RNA	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTAAAGAATTCAAAGCTCAGA	0.443000													3	29					0	0	0	0
KLHL31	401265	broad.mit.edu	37	6	53519694	53519694	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:53519694G>A	uc003pcb.3	-	2	518	c.377C>T	c.(376-378)GCA>GTA	p.A126V		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	126	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					GTAGGCATATGCAATGACAGT	0.413000													56	229					0	0	0	0
SLC35F1	222553	broad.mit.edu	37	6	118596680	118596680	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:118596680T>G	uc003pxx.3	+	5	897	c.696T>G	c.(694-696)ATT>ATG	p.I232M	SLC35F1_uc003pxy.1_Missense_Mutation_p.I37M	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	232	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TCTATGGTATTTCTAACGTCT	0.443000													25	44					0	0	0	0
RADIL	55698	broad.mit.edu	37	7	4917507	4917507	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:4917507G>A	uc003snj.1	-	2	437	c.264C>T	c.(262-264)AGC>AGT	p.S88S	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	88	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCTCACGGGCGCTGGAGGTGC	0.672000													7	53					0	0	0	0
EPDR1	54749	broad.mit.edu	37	7	37988563	37988563	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:37988563T>A	uc003tfp.2	+	2	770	c.751T>A	c.(751-753)TCC>ACC	p.S251T	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.S70T	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	131					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						TCCTCAAAACTCCACCTTTGA	0.512000													7	82					0	0	0	0
TNS3	64759	broad.mit.edu	37	7	47342762	47342762	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:47342762G>A	uc003tnv.2	-	22	3610	c.3243C>T	c.(3241-3243)CAC>CAT	p.H1081H	TNS3_uc003tnw.2_Silent_p.H1081H	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1081						focal adhesion	protein binding			ovary(4)	4						GGCCTGGACTGTGGTGGCTGC	0.667000													7	32					0	0	0	0
ABHD11	83451	broad.mit.edu	37	7	73152999	73152999	+	Silent	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:73152999G>A	uc003tzb.2	-	1	186	c.129C>T	c.(127-129)GGC>GGT	p.G43G	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Silent_p.G43G|ABHD11_uc003tzc.2_Silent_p.G43G|ABHD11_uc003tza.2_5'UTR|ABHD11_uc003tzf.2_Silent_p.G43G|ABHD11_uc011kfc.1_Silent_p.G43G	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	43							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CCCCTCGGCCGCCGCTGCTGC	0.741000													4	4					0	0	0	0
PION	54103	broad.mit.edu	37	7	76984631	76984631	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:76984631A>T	uc003ugf.2	-	16	1316	c.1237T>A	c.(1237-1239)TTA>ATA	p.L413I	PION_uc003ugg.1_Missense_Mutation_p.L198I	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	413					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						AGCTGTAATAAAGACGACTGG	0.502000													34	74					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82581457	82581457	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:82581457C>G	uc003uhx.2	-	5	9101	c.8812G>C	c.(8812-8814)GCT>CCT	p.A2938P	PCLO_uc003uhv.2_Missense_Mutation_p.A2938P|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2869					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGCACACAGCTCTTCTCCCT	0.433000													8	91					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963672	88963672	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:88963672C>T	uc011khi.1	+	4	1914	c.1376C>T	c.(1375-1377)ACG>ATG	p.T459M		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	459						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAATGGCCTACGGAACTTCTG	0.428000										HNSCC(36;0.09)			23	52					0	0	0	0
CUX1	1523	broad.mit.edu	37	7	101740740	101740740	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:101740740T>G	uc003uyx.3	+	5	403	c.365T>G	c.(364-366)CTG>CGG	p.L122R	CUX1_uc003uys.3_Missense_Mutation_p.L133R|CUX1_uc003uyt.2_Missense_Mutation_p.L133R|CUX1_uc011kkn.1_Missense_Mutation_p.L96R|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Missense_Mutation_p.L117R|CUX1_uc003uyu.2_Missense_Mutation_p.L133R	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	122	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						AGGGAAACTCTGGAAGAATAC	0.378000													6	64					0	0	0	0
C7orf58	79974	broad.mit.edu	37	7	120737809	120737809	+	Missense_Mutation	SNP	C	T	T	rs144805034	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:120737809C>T	uc003vjq.3	+	6	1120	c.673C>T	c.(673-675)CCG>TCG	p.P225S	C7orf58_uc003vjr.1_Missense_Mutation_p.P225S|C7orf58_uc003vjs.3_Missense_Mutation_p.P225S|C7orf58_uc003vjt.3_Missense_Mutation_p.P5S|C7orf58_uc010lkk.1_Missense_Mutation_p.P5S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	225						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GCAATTAAAGCCGAGTACTTC	0.428000													6	109					0	0	0	0
LMOD2	442721	broad.mit.edu	37	7	123302785	123302785	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:123302785G>C	uc003vky.2	+	2	1302	c.1145G>C	c.(1144-1146)AGA>ACA	p.R382T		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	382						cytoskeleton	actin binding|tropomyosin binding				0						GTCTGGCAAAGAGGAACACCT	0.488000													32	47					0	0	0	0
PARP12	64761	broad.mit.edu	37	7	139741483	139741483	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:139741483C>A	uc003vvl.1	-	6	2017	c.1143G>T	c.(1141-1143)TGG>TGT	p.W381C	PARP12_uc003vvk.1_Missense_Mutation_p.W167C|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	381	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					ACTCATCACTCCAGTACCAAA	0.512000													74	125					1.36236e-49	1.5791e-49	1	0
WEE2	494551	broad.mit.edu	37	7	141408764	141408764	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:141408764C>T	uc003vwn.2	+	1	612	c.206C>T	c.(205-207)TCT>TTT	p.S69F	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	69					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					CTCGACACATCTTCGGAAAAA	0.522000													15	191					0	0	0	0
PRSS37	136242	broad.mit.edu	37	7	141537030	141537030	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:141537030C>T	uc003vws.1	-	4	821	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	PRSS37_uc011krk.1_Missense_Mutation_p.R137Q|PRSS37_uc011krl.1_Missense_Mutation_p.R149Q|PRSS37_uc003vwt.1_Missense_Mutation_p.R137Q	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	150	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						CAGGTTCTGCCGCAAGTCAGG	0.458000													24	60					0	0	0	0
IMPA1	3612	broad.mit.edu	37	8	82572902	82572902	+	Silent	SNP	C	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:82572902C>G	uc003ych.2	-	8	694	c.567G>C	c.(565-567)GGG>GGC	p.G189G	IMPA1_uc011lfq.1_Silent_p.G248G|IMPA1_uc011lfr.1_Missense_Mutation_p.G153A	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	189					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	CACTCCGGATCCTAACAAATA	0.378000													10	35					0	0	0	0
CNBD1	168975	broad.mit.edu	37	8	87951834	87951834	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:87951834G>A	uc003ydy.2	+	4	331	c.283G>A	c.(283-285)GAA>AAA	p.E95K		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	95										ovary(3)	3						GGAACTCAATGAAGGCAAAGA	0.338000													12	62					0	0	0	0
FAM49B	51571	broad.mit.edu	37	8	130854420	130854420	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:130854420T>C	uc003yss.2	-	15	1492	c.943A>G	c.(943-945)ACC>GCC	p.T315A	FAM49B_uc003yst.2_Missense_Mutation_p.T315A|FAM49B_uc003ysu.2_Missense_Mutation_p.T315A|FAM49B_uc003ysv.2_Missense_Mutation_p.T169A|FAM49B_uc003ysw.2_Missense_Mutation_p.T315A|FAM49B_uc003ysx.2_Missense_Mutation_p.T315A	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	315											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TGCTTGGAGGTAGTCTCATCA	0.328000													5	47					0	0	0	0
ADCY8	114	broad.mit.edu	37	8	131964216	131964216	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:131964216C>T	uc003ytd.3	-	3	1395	c.1139G>A	c.(1138-1140)CGG>CAG	p.R380Q	ADCY8_uc010mds.2_Missense_Mutation_p.R380Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	380	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GACAACAAACCGGGGGAGCAC	0.547000										HNSCC(32;0.087)			21	21					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139706770	139706770	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:139706770T>A	uc003yvd.2	-	34	3128	c.2681A>T	c.(2680-2682)CAG>CTG	p.Q894L	COL22A1_uc011ljo.1_Missense_Mutation_p.Q194L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	894	Pro-rich.|Gly-rich.|Collagen-like 7.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGTGGGTCCCTGAGGCCCCAA	0.612000										HNSCC(7;0.00092)			58	59					0	0	0	0
UHRF2	115426	broad.mit.edu	37	9	6460622	6460622	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:6460622C>T	uc003zjy.2	+	4	1034	c.694C>T	c.(694-696)CGA>TGA	p.R232*	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zka.1_Nonsense_Mutation_p.R9*	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	232	Interaction with PCNP.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		TCTTAGACCACGAGCTAGAAC	0.373000													30	34					0	0	0	0
PRKACG	5568	broad.mit.edu	37	9	71628058	71628058	+	Silent	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:71628058C>T	uc004agy.2	-	1	982	c.951G>A	c.(949-951)CCG>CCA	p.P317P		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	317	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CTGTGTACTTCGGGATGAAGG	0.532000													40	11					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	118973944	118973944	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:118973944T>C	uc004bjn.2	+	4	2032	c.1651T>C	c.(1651-1653)TAT>CAT	p.Y551H	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	551	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CCCATCTTTCTATGGCATGCC	0.517000													26	49					0	0	0	0
FPGS	2356	broad.mit.edu	37	9	130566689	130566689	+	Silent	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:130566689G>T	uc004bsg.1	+	2	314	c.264G>T	c.(262-264)CTG>CTT	p.L88L	FPGS_uc004bsf.1_RNA|FPGS_uc004bsh.1_5'UTR|FPGS_uc011mal.1_Silent_p.L88L|FPGS_uc004bsi.1_Silent_p.L38L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	88					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	GGAGTGGGCTGCAGGTAAGGT	0.607000													22	32					1.36565e-18	1.52236e-18	1	0
WDR34	89891	broad.mit.edu	37	9	131396039	131396039	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:131396039G>T	uc004bvq.1	-	9	1719	c.1595C>A	c.(1594-1596)GCA>GAA	p.A532E	WDR34_uc004bvs.1_Missense_Mutation_p.A523E|WDR34_uc004bvr.1_Missense_Mutation_p.A504E	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	532						cytoplasm				central_nervous_system(2)|skin(1)	3						CGCCACCTCTGCTGCCAGGCA	0.627000													122	166					1.61494e-73	1.89337e-73	1	0
FAM47C	442444	broad.mit.edu	37	X	37028771	37028771	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:37028771G>A	uc004ddl.1	+	1	2302	c.2288G>A	c.(2287-2289)CGC>CAC	p.R763H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	763										ovary(3)	3						TCTCATCTCCGCCCGGAGCCT	0.627000													15	8					0	0	0	0
CCNB3	85417	broad.mit.edu	37	X	50053854	50053854	+	Silent	SNP	T	G	G			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:50053854T>G	uc004dox.3	+	6	2983	c.2685T>G	c.(2683-2685)TCT>TCG	p.S895S	CCNB3_uc004doy.2_Silent_p.S895S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	895					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TCAAGGAGTCTTTGGACTTGC	0.502000													7	8					0	0	0	0
DGKK	139189	broad.mit.edu	37	X	50121103	50121103	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:50121103T>A	uc010njr.1	-	23	3165	c.3105A>T	c.(3103-3105)AGA>AGT	p.R1035S		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1035					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTACCCGATCTCTTGTCAGCA	0.453000													20	16					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53622348	53622348	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:53622348C>T	uc004dsp.2	-	30	3581	c.3179G>A	c.(3178-3180)GGC>GAC	p.G1060D	HUWE1_uc004dsn.2_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1060					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AAGTGCTCGGCCTAATCTGGA	0.423000													12	2					0	0	0	0
MAGED2	10916	broad.mit.edu	37	X	54836452	54836452	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:54836452G>C	uc004dtk.1	+	3	437	c.343G>C	c.(343-345)GCT>CCT	p.A115P	MAGED2_uc004dtl.1_Missense_Mutation_p.A115P|MAGED2_uc004dtm.1_Missense_Mutation_p.A77P|MAGED2_uc010nkc.1_Missense_Mutation_p.A115P|MAGED2_uc004dtn.1_Missense_Mutation_p.A115P|MAGED2_uc004dto.1_Missense_Mutation_p.A89P	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	115										ovary(2)|breast(1)	3						TGACCCGCAGGCTGTGACAAT	0.527000													3	13					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962753	73962753	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:73962753G>A	uc004eby.2	-	3	2256	c.1639C>T	c.(1639-1641)CGC>TGC	p.R547C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	547					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CCTTTAAAGCGATTAATGATG	0.403000													29	22					0	0	0	0
CXorf57	55086	broad.mit.edu	37	X	105881011	105881011	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:105881011C>T	uc004emi.3	+	8	1581	c.1430C>T	c.(1429-1431)ACG>ATG	p.T477M	CXorf57_uc004emj.3_Missense_Mutation_p.T477M|CXorf57_uc004emh.2_Missense_Mutation_p.T477M	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	477								p.T477M(1)		ovary(1)|lung(1)|breast(1)	3						CAGCCGTATACGTATGATGCC	0.373000													4	47					0	0	0	0
RGAG1	57529	broad.mit.edu	37	X	109694160	109694160	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:109694160G>A	uc004eor.1	+	3	561	c.315G>A	c.(313-315)ATG>ATA	p.M105I	RGAG1_uc011msr.1_Missense_Mutation_p.M105I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	105										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CATTGCTAATGCCAGCCTCAG	0.527000													89	44					0	0	0	0
DDX26B	203522	broad.mit.edu	37	X	134714085	134714085	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:134714085G>A	uc004eyw.3	+	15	2744	c.2381G>A	c.(2380-2382)CGA>CAA	p.R794Q	DDX26B_uc004eyx.3_Missense_Mutation_p.R395Q	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	794											0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTTTGGTCGAAGTAAGTAG	0.388000													6	37					0	0	0	0
Unknown	0	broad.mit.edu	37	1	143391935	143391936	+	IGR	INS	-	TG	TG			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:143391935_143391936insTG								None (None upstream) : LOC100286793 (255703 downstream)																							ATATATATATATAAAGAGATTG	0.252													---	---	---							
NOC3L	64318	broad.mit.edu	37	10	96097619	96097620	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:96097619_96097620insA	uc001kjq.1	-	19	2191_2192	c.2103_2104insT	c.(2101-2106)CATCCCfs	p.H701fs		NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	701_702						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TGCACTATGGGATGATAATGCC	0.431													---	---	---							
UHRF1BP1L	23074	broad.mit.edu	37	12	100441863	100441865	+	In_Frame_Del	DEL	AAT	-	-			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:100441863_100441865delAAT	uc001tgq.2	-	18	4057_4059	c.3828_3830delATT	c.(3826-3831)GGATTT>GGT	p.F1277del	UHRF1BP1L_uc001tgp.2_In_Frame_Del_p.F927del	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1277										ovary(2)	2						GCACTGCAGAAATCCATTTTTTT	0.365													---	---	---							
KIAA0753	9851	broad.mit.edu	37	17	6493123	6493139	+	Frame_Shift_Del	DEL	AAGGAGCCTACAGCCTC	-	-			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:6493123_6493139delAAGGAGCCTACAGCCTC	uc002gde.3	-	18	3105_3121	c.2746_2762delGAGGCTGTAGGCTCCTT	c.(2746-2763)GAGGCTGTAGGCTCCTTCfs	p.E916fs	KIAA0753_uc010vtd.1_Frame_Shift_Del_p.E372fs|KIAA0753_uc010clo.2_Frame_Shift_Del_p.E617fs|KIAA0753_uc010vte.1_Frame_Shift_Del_p.E617fs	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	916_921						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		CCACGGGTTGAAGGAGCCTACAGCCTCATGAGATATG	0.470													---	---	---							
MIR527	574497	broad.mit.edu	37	19	54255879	54255881	+	5'Flank	DEL	TTT	-	-	rs72385066		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:54255879_54255881delTTT	hsa-mir-527|MI0003179	+																							0						ttgttttttgttttttttttttt	0.103													---	---	---							
GRB14	2888	broad.mit.edu	37	2	165365288	165365288	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:165365288delT	uc002ucl.2	-	7	1432	c.891delA	c.(889-891)AAAfs	p.K297fs	GRB14_uc010zcv.1_Frame_Shift_Del_p.K210fs|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	297	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GTGCTCCATGTTTTTTTTTGC	0.373													---	---	---							
Unknown	0	broad.mit.edu	37	20	5272907	5272907	+	IGR	DEL	A	-	-			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:5272907delA								CDS2 (100920 upstream) : PROKR2 (9780 downstream)																							GGAGGGAGGtaaaaaaaaata	0.328													---	---	---							
TLE1	7088	broad.mit.edu	37	9	84202720	84202720	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:84202720delC	uc004aly.2	-	17	2294	c.1853delG	c.(1852-1854)GGAfs	p.G618fs	TLE1_uc004alz.2_Frame_Shift_Del_p.G628fs|TLE1_uc011lsr.1_Frame_Shift_Del_p.G603fs	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	618	WD 4.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ACAGCTGGCTCCGTCTGTGTG	0.502													---	---	---							
