Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	53					0	0	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:16946434C>T	uc010ocf.1	-	3		c.464G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						CTCAGCCTTCCGCCGGGCCAG	0.672000													3	18					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19478948	19478948	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:19478948C>T	uc001bbi.2	-	47	6859	c.6855G>A	c.(6853-6855)GTG>GTA	p.V2285V	UBR4_uc001bbk.1_5'Flank|UBR4_uc001bbl.1_Silent_p.V222V|UBR4_uc001bbm.1_Silent_p.V1497V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2285					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGGAAAGTCACCTGGCTAG	0.507000													8	153					0	0	0	0
C1orf38	9473	broad.mit.edu	37	1	28208651	28208651	+	Silent	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:28208651C>G	uc001bpc.3	+	4	844	c.816C>G	c.(814-816)CGC>CGG	p.R272R	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Intron	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	272	CABIT 2.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CTGAGGGCCGCCCCATCTTCC	0.632000													14	35					0	0	0	0
COL9A2	1298	broad.mit.edu	37	1	40775985	40775985	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:40775985G>A	uc001cfh.1	-	14	759	c.689C>T	c.(688-690)CCC>CTC	p.P230L	COL9A2_uc001cfi.1_Missense_Mutation_p.P49L	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	230	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GATGCCCTGGGGACCCTGTTG	0.378000													6	71					0	0	0	0
PTGFR	5737	broad.mit.edu	37	1	78958948	78958948	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:78958948C>T	uc001din.2	+	2	786	c.520C>T	c.(520-522)CAT>TAT	p.H174Y	PTGFR_uc001dim.2_Missense_Mutation_p.H174Y	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	174	Helical; Name=4; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CATCCTTGGACATCGAGACTA	0.368000													11	131					0	0	0	0
WDR63	126820	broad.mit.edu	37	1	85560225	85560225	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:85560225C>T	uc001dkt.2	+	10	1351	c.1160C>T	c.(1159-1161)CCT>CTT	p.P387L	WDR63_uc009wcl.2_Missense_Mutation_p.P348L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	387										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TTCTCTGATCCTATACATCCT	0.383000													6	183					0	0	0	0
CLCA4	22802	broad.mit.edu	37	1	87031654	87031654	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:87031654T>C	uc009wcs.2	+	6	949	c.905T>C	c.(904-906)ATC>ACC	p.I302T	CLCA4_uc009wct.2_Missense_Mutation_p.I65T|CLCA4_uc009wcu.2_Missense_Mutation_p.I122T	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	302						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTGCTGAAGATCAGTCAAAGA	0.413000													25	84					0	0	0	0
SLC6A17	388662	broad.mit.edu	37	1	110709557	110709557	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:110709557G>A	uc009wfq.2	+	2	467	c.6G>A	c.(4-6)CCG>CCA	p.P2P		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	2	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CATCAATGCCGAAGAACAGCA	0.572000													12	11					0	0	0	0
NBPF15	284565	broad.mit.edu	37	1	148594513	148594513	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:148594513G>A	uc001esc.2	+	19	2375	c.1886G>A	c.(1885-1887)AGA>AAA	p.R629K		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	629	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					CAGCACTACAGAAGTGTGTTT	0.438000													18	421					0	0	0	0
FCRL4	83417	broad.mit.edu	37	1	157557115	157557115	+	Silent	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:157557115C>G	uc001fqw.2	-	5	934	c.798G>C	c.(796-798)GTG>GTC	p.V266V	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	266	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TGTTACCCCTCACTGTTTCAG	0.572000													108	218					0	0	0	0
CFHR4	10877	broad.mit.edu	37	1	196871631	196871631	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:196871631G>T	uc001gto.2	+	2	211	c.142G>T	c.(142-144)GCA>TCA	p.A48S	CFHR4_uc009wyy.2_Missense_Mutation_p.A47S|CFHR4_uc001gtp.2_Missense_Mutation_p.A48S	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	48	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TCCAGCAGCTGCAGGACAATC	0.363000													20	117					4.35082e-09	4.82033e-09	1	0
USH2A	7399	broad.mit.edu	37	1	215955425	215955425	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:215955425G>T	uc001hku.1	-	54	11086	c.10699C>A	c.(10699-10701)CTG>ATG	p.L3567M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3567	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAGCTTTCAGCTGATATGAA	0.438000										HNSCC(13;0.011)			26	64					2.41591e-17	2.75593e-17	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72511852	72511852	+	Silent	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:72511852G>T	uc001jrh.2	+	18	2598	c.2598G>T	c.(2596-2598)GGG>GGT	p.G866G	ADAMTS14_uc001jrg.2_Silent_p.G869G	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	866	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCCCATAGGGATCCAGTTCA	0.662000													8	20					0.00307968	0.00318302	1	0
BLNK	29760	broad.mit.edu	37	10	97956812	97956812	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:97956812G>C	uc001kls.3	-	16	1281	c.1103C>G	c.(1102-1104)TCA>TGA	p.S368*	BLNK_uc001kme.3_Nonsense_Mutation_p.S263*|BLNK_uc001klt.3_Nonsense_Mutation_p.S259*|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Intron|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Nonsense_Mutation_p.S345*|BLNK_uc001kly.3_Intron|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Intron|BLNK_uc001kmb.3_Nonsense_Mutation_p.S164*|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Nonsense_Mutation_p.S286*|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	368	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		AATAAGAAATGATCCATCCTG	0.269000													5	36					0	0	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133962932	133962932	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:133962932C>T	uc001lkx.3	+	14	1865	c.1865C>T	c.(1864-1866)TCA>TTA	p.S622L	JAKMIP3_uc009yba.1_Missense_Mutation_p.S59L	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAGAGGAAGTCACCCGCCATC	0.647000													6	12					0	0	0	0
ART1	417	broad.mit.edu	37	11	3680852	3680852	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:3680852C>G	uc001lye.1	+	3	204	c.103C>G	c.(103-105)CAA>GAA	p.Q35E	ART1_uc009yeb.1_Missense_Mutation_p.Q35E	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	35					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CCTCTTCTCTCAAGAGATTCA	0.602000													12	38					0	0	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537578	5537578	+	Missense_Mutation	SNP	G	C	C	rs140401116		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:5537578G>C	uc001maz.3	-	1	379	c.94C>G	c.(94-96)CGA>GGA	p.R32G	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	32	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		ACTATCACTCGAGTGGCACTT	0.483000													4	91					0	0	0	0
KIF18A	81930	broad.mit.edu	37	11	28084055	28084055	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:28084055C>A	uc001msc.2	-	12	1781	c.1599G>T	c.(1597-1599)AAG>AAT	p.K533N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	533					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						GAAGATCTTTCTTGAGTTCCT	0.323000													22	49					4.4004e-07	4.77227e-07	1	0
Unknown	0	broad.mit.edu	37	11	56144000	56144000	+	IGR	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:56144000C>G								OR8J1 (15329 upstream) : OR5R1 (40736 downstream)																							GAAAGAAGCTCTGAAGAAAAT	0.348000													20	110					0	0	0	0
SCYL1	57410	broad.mit.edu	37	11	65304114	65304114	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:65304114C>T	uc001oea.1	+	13	1786	c.1709C>T	c.(1708-1710)GCA>GTA	p.A570V	SCYL1_uc009yqk.2_Missense_Mutation_p.A570V|SCYL1_uc001oeb.1_Missense_Mutation_p.A570V|SCYL1_uc001oec.1_Missense_Mutation_p.A570V|SCYL1_uc001oed.1_Missense_Mutation_p.A427V|SCYL1_uc001oee.1_Missense_Mutation_p.A214V	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	570					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						GCTAGCTGGGCAGGCTGGGCC	0.627000													12	67					0	0	0	0
SYT12	91683	broad.mit.edu	37	11	66811318	66811318	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:66811318G>A	uc009yrl.2	+	5	1061	c.831G>A	c.(829-831)CAG>CAA	p.Q277Q	SYT12_uc001oju.2_Silent_p.Q277Q	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	277	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						TACAGGACCAGAACAAGGTAA	0.552000													14	49					0	0	0	0
ANO1	55107	broad.mit.edu	37	11	70007358	70007358	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:70007358G>A	uc001opj.2	+	17	1975	c.1670G>A	c.(1669-1671)CGG>CAG	p.R557Q	ANO1_uc001opk.1_Missense_Mutation_p.R499Q|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.R266Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	557	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCCTCCGTGCGGTCCAACATC	0.592000													23	69					0	0	0	0
FZD4	8322	broad.mit.edu	37	11	86662820	86662820	+	Silent	SNP	A	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:86662820A>G	uc001pce.2	-	2	1284	c.978T>C	c.(976-978)ACT>ACC	p.T326T	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	326	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCAAAAACCAAGTGAGTGTCA	0.453000													4	22					0	0	0	0
WNK1	65125	broad.mit.edu	37	12	989016	989016	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:989016C>T	uc001qio.3	+	11	3158	c.2651C>T	c.(2650-2652)GCG>GTG	p.A884V	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	884					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAACAGCTGCGATCCCGGGG	0.547000													25	95					0	0	0	0
FKBP4	2288	broad.mit.edu	37	12	2909727	2909727	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:2909727T>C	uc001qkz.2	+	8	1214	c.1016T>C	c.(1015-1017)ATT>ACT	p.I339T		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	339	TPR 2.|Interaction with tubulin (By similarity).				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	TCTGCTGCCATTGAAAGCTGT	0.532000													9	39					0	0	0	0
AICDA	57379	broad.mit.edu	37	12	8757515	8757515	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:8757515T>A	uc001qur.2	-	4	510	c.431A>T	c.(430-432)TAT>TTT	p.Y144F	AICDA_uc001qup.1_Intron|AICDA_uc001quq.1_Intron|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	144					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					GCAGTAAAAATAATCTTCAAA	0.428000									Immune_Deficiency_with_Hyper-IgM				10	29					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20801805	20801805	+	Missense_Mutation	SNP	G	A	A	rs148455779		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:20801805G>A	uc001reh.1	+	13	2771	c.2749G>A	c.(2749-2751)GTA>ATA	p.V917I		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	917	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTTTGACTTCGTAGCCAAATT	0.269000													18	60					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53680134	53680134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:53680134C>T	uc001sck.2	+	18	3705	c.3614C>T	c.(3613-3615)TCC>TTC	p.S1205F	ESPL1_uc001scj.2_Missense_Mutation_p.S880F|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1205					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTCCAAGCTTCCCTGAATCAT	0.587000													28	99					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57571375	57571375	+	Splice_Site	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:57571375G>T	uc001snd.2	+	26	4827	c.4361_splice	c.e26+1	p.R1454_splice		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGACGCCAGGTCAGCACCCT	0.652000													9	19					2.74318e-10	3.08357e-10	1	0
LRIG3	121227	broad.mit.edu	37	12	59272720	59272720	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:59272720C>A	uc001sqr.2	-	14	2215	c.1969G>T	c.(1969-1971)GAG>TAG	p.E657*	LRIG3_uc009zqh.2_Nonsense_Mutation_p.E597*|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	657	Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			ACGTCATCCTCGGGCATCACA	0.552000													9	95					0.000274275	0.000287336	1	0
PPFIA2	8499	broad.mit.edu	37	12	81762943	81762943	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:81762943G>A	uc001szo.1	-	12	1458	c.1297C>T	c.(1297-1299)CGT>TGT	p.R433C	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	359										ovary(3)|lung(2)|pancreas(1)	6						TGTCTCATACGTTCTTCAATA	0.318000													6	17					0	0	0	0
XPO4	64328	broad.mit.edu	37	13	21375044	21375044	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr13:21375044C>A	uc001unq.3	-	14	1939	c.1903G>T	c.(1903-1905)GGC>TGC	p.G635C		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	635					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		ATATCTTTGCCCATCTGGGGA	0.393000													35	142					4.3181e-19	4.96259e-19	1	0
RXFP2	122042	broad.mit.edu	37	13	32339254	32339254	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr13:32339254A>C	uc001utt.2	+	4	471	c.400A>C	c.(400-402)ATG>CTG	p.M134L	RXFP2_uc010aba.2_Missense_Mutation_p.M117L	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	134	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GTCTGTGCCGATGATTTCTAA	0.348000													6	73					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47530570	47530570	+	Silent	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:47530570T>C	uc001wwj.3	-	7	1396	c.1200A>G	c.(1198-1200)ACA>ACG	p.T400T	MDGA2_uc001wwi.3_Silent_p.T171T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	400	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGTCCAAGTTTGTTGTTCCCG	0.403000													8	182					0	0	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68050595	68050596	+	Silent	DNP	GC	AT	AT			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:68050595_68050596GC>AT	uc001xjl.1	+	25	3706_3707	c.3564_3565GC>AT	c.(3562-3567)CAGCTG>CAATTG	p.1188_1189QL>QL	PLEKHH1_uc010tsw.1_Silent_p.756_757QL>QL|PLEKHH1_uc001xjn.1_Silent_p.703_704QL>QL|PLEKHH1_uc010tsx.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjo.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjp.1_Silent_p.53_54QL>QL	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	1188_1189	FERM.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCGCTGAACAGCTGAGGTAGGT	0.584000											OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257020	69257020	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:69257020C>G	uc001xkh.1	-	2	377	c.247G>C	c.(247-249)GAC>CAC	p.D83H	ZFP36L1_uc001xki.1_Missense_Mutation_p.D83H	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	83					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AAGCGGCTGTCTCGCGAGCTC	0.682000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	31					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88934592	88934592	+	Missense_Mutation	SNP	T	G	G	rs151002751	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:88934592T>G	uc001xwv.3	-	19	3745	c.3414A>C	c.(3412-3414)AGA>AGC	p.R1138S	PTPN21_uc010twc.1_Missense_Mutation_p.R934S	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1138	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TGTCCAGCACTCTCGGGATGT	0.512000													5	133					0	0	0	0
ADSSL1	122622	broad.mit.edu	37	14	105201381	105201381	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:105201381G>T	uc001ypd.2	+	2	291	c.217G>T	c.(217-219)GTG>TTG	p.V73L	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.V116L|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	73					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CGGCCACACGGTGGTGGTGGA	0.627000													4	21					0.00909568	0.00933823	1	0
DUOX1	53905	broad.mit.edu	37	15	45428812	45428812	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:45428812C>T	uc001zus.1	+	10	1357	c.1011C>T	c.(1009-1011)GGC>GGT	p.G337G	DUOX1_uc001zut.1_Silent_p.G337G|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	337	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TGCCCCCTGGCGTCTACATGA	0.592000													11	52					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50867173	50867173	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:50867173G>A	uc001zyt.3	-	34	5159	c.4895C>T	c.(4894-4896)ACC>ATC	p.T1632I	TRPM7_uc001zyr.2_Missense_Mutation_p.T69I	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1632	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTCTGACCAGGTACACTGTAC	0.388000													33	115					0	0	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042710	75042710	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:75042710G>A	uc002ayr.1	+	2	695	c.631G>A	c.(631-633)GAG>AAG	p.E211K		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	211					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GCACTTCCCTGAGAGTAGCGA	0.577000													26	173					0	0	0	0
PDXDC1	23042	broad.mit.edu	37	16	15110041	15110041	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:15110041G>C	uc002dda.3	+	9	1007	c.783G>C	c.(781-783)GAG>GAC	p.E261D	PDXDC1_uc010uzl.1_Missense_Mutation_p.E246D|PDXDC1_uc010uzm.1_Missense_Mutation_p.E170D|PDXDC1_uc002dcz.2_Missense_Mutation_p.E238D|PDXDC1_uc002ddb.3_Missense_Mutation_p.E234D|PDXDC1_uc010uzn.1_Missense_Mutation_p.E233D|PDXDC1_uc002ddc.2_Missense_Mutation_p.E261D	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	261					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	AACTCTGTGAGCAGTATGGCA	0.502000													8	55					0	0	0	0
HPR	3250	broad.mit.edu	37	16	72110502	72110502	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:72110502G>A	uc002fby.2	+	5	599	c.569G>A	c.(568-570)GGG>GAG	p.G190E	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	190	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				GTAGATATTGGGCTCATCAAA	0.448000													15	75					0	0	0	0
KCNG4	93107	broad.mit.edu	37	16	84270496	84270496	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:84270496C>T	uc010voc.1	-	2	717	c.596G>A	c.(595-597)CGC>CAC	p.R199H	KCNG4_uc002fhu.1_Missense_Mutation_p.R199H	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	199						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGGCCCCAGCGCGAGGAGTG	0.677000													15	36					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	24					0	0	0	0
MYH3	4621	broad.mit.edu	37	17	10542363	10542363	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:10542363C>G	uc002gmq.1	-	24	3323	c.3246G>C	c.(3244-3246)AAG>AAC	p.K1082N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1082	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.K1082N(1)		ovary(4)|central_nervous_system(2)|pancreas(1)	7						GGGCATACTTCTTGAGCCTTT	0.398000													22	71					0	0	0	0
KRT14	3861	broad.mit.edu	37	17	39740142	39740142	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:39740142C>G	uc002hxf.1	-	4	858	c.797G>C	c.(796-798)GGA>GCA	p.G266A	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.G266A	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	266	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				ATTGACATCTCCACCCACCTG	0.577000													9	108					0	0	0	0
SPOP	8405	broad.mit.edu	37	17	47679366	47679366	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:47679366C>A	uc010dbk.2	-	10	1473	c.841G>T	c.(841-843)GCC>TCC	p.A281S	SPOP_uc002ipb.2_Missense_Mutation_p.A281S|SPOP_uc002ipc.2_Missense_Mutation_p.A281S|SPOP_uc002ipd.2_Missense_Mutation_p.A281S|SPOP_uc002ipe.2_Missense_Mutation_p.A281S|SPOP_uc002ipf.2_Missense_Mutation_p.A281S|SPOP_uc002ipg.2_Missense_Mutation_p.A281S	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	281	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CGCTCCAGGGCATACTGTAAA	0.493000										Prostate(2;0.17)			42	45					6.48837e-15	7.34712e-15	1	0
SGCA	6442	broad.mit.edu	37	17	48245850	48245850	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:48245850C>T	uc002iqi.2	+	5	537	c.501C>T	c.(499-501)CCC>CCT	p.P167P	SGCA_uc010wmh.1_Silent_p.P65P|SGCA_uc002iqj.2_Silent_p.P167P|SGCA_uc010wmi.1_RNA|uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	167	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						TCTGGGAGCCCGGAGAGCTTC	0.642000													5	1					0	0	0	0
GNAL	2774	broad.mit.edu	37	18	11872355	11872355	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr18:11872355G>C	uc010dkz.2	+	11	1135	c.889G>C	c.(889-891)GAC>CAC	p.D297H	GNAL_uc002kqc.2_Missense_Mutation_p.D374H|GNAL_uc002kqd.2_Missense_Mutation_p.D297H|GNAL_uc010wzt.1_Missense_Mutation_p.D90H	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	297					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						AAAAATTGAAGACTATTTCCC	0.333000													24	71					0	0	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747352	7747352	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:7747352G>A	uc002mhi.1	+	2	283	c.213G>A	c.(211-213)GCG>GCA	p.A71A	TRAPPC5_uc002mhj.1_Silent_p.A71A|TRAPPC5_uc002mhk.1_Silent_p.A71A	NM_001042462	NP_001035927	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	71					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding				0						CGCTGGTGGCGCGCGAAAAGG	0.711000													10	27					0	0	0	0
LPPR2	64748	broad.mit.edu	37	19	11470246	11470246	+	Silent	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:11470246C>G	uc002mre.1	+	4	442	c.105C>G	c.(103-105)CGC>CGG	p.R35R	LPPR2_uc002mrf.1_Intron|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	35						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TTGCTTACCGCCTGGAGTTCA	0.622000													9	49					0	0	0	0
OR10H1	26539	broad.mit.edu	37	19	15918404	15918404	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:15918404G>A	uc002nbq.2	-	1	533	c.444C>T	c.(442-444)TCC>TCT	p.S148S		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCAGCCCAGGAGCAGCCCA	0.632000													4	82					0	0	0	0
SIN3B	23309	broad.mit.edu	37	19	16974605	16974605	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:16974605G>A	uc002ney.1	+	11	1491	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	SIN3B_uc002nez.1_Missense_Mutation_p.E461K|SIN3B_uc010xpi.1_Missense_Mutation_p.E51K	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	493	Interaction with SDS3 and HDAC1 (By similarity).|Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						CGAGCGCTTCGAGGTGTGTGT	0.612000													12	41					0	0	0	0
ZNF100	163227	broad.mit.edu	37	19	21909496	21909496	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:21909496G>C	uc002nqi.2	-	5	1817	c.1618C>G	c.(1618-1620)CTA>GTA	p.L540V	ZNF100_uc002nqh.2_Missense_Mutation_p.L476V	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACATTTGTAGGGTTTCTCTC	0.363000													3	44					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22157388	22157388	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:22157388A>G	uc002nqp.2	-	4	597	c.448T>C	c.(448-450)TAT>CAT	p.Y150H	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGCATATTTGCCACGT	0.328000													21	81					0	0	0	0
MAG	4099	broad.mit.edu	37	19	35791165	35791165	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:35791165C>T	uc002nyy.1	+	6	977	c.828C>T	c.(826-828)GAC>GAT	p.D276D	MAG_uc002nyx.1_Silent_p.D276D|MAG_uc010eds.1_Silent_p.D251D|MAG_uc002nyz.1_Silent_p.D276D	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	276	Ig-like C2-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGATGCGGGACGGGACAGTCC	0.687000													4	14					0	0	0	0
HIPK4	147746	broad.mit.edu	37	19	40887043	40887043	+	Silent	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:40887043G>C	uc002onp.2	-	3	1140	c.855C>G	c.(853-855)CTC>CTG	p.L285L		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	285	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCAACGACTTGAGCATATACT	0.632000													12	34					0	0	0	0
B3GNT8	374907	broad.mit.edu	37	19	41932174	41932174	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:41932174C>T	uc002oqs.2	-	3	964	c.510G>A	c.(508-510)ACG>ACA	p.T170T	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	170	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						GACTGCCCCACGTCTCTCTCA	0.627000													22	76					0	0	0	0
VIT	5212	broad.mit.edu	37	2	37028521	37028521	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:37028521C>T	uc002rpl.2	+	13	1357	c.1136C>T	c.(1135-1137)ACT>ATT	p.T379I	VIT_uc002rpm.2_Missense_Mutation_p.T357I|VIT_uc010ezv.2_Missense_Mutation_p.T335I|VIT_uc010ezw.2_Missense_Mutation_p.T336I	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	364	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GAGAAAATTACTCAGAGAGGA	0.393000													13	167					0	0	0	0
CNGA3	1261	broad.mit.edu	37	2	99013475	99013475	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:99013475G>A	uc002syt.2	+	8	2259	c.1842G>A	c.(1840-1842)GAG>GAA	p.E614E	CNGA3_uc002syu.2_Silent_p.E596E|CNGA3_uc010fij.2_Silent_p.E618E	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	614					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGATCGATGAGGAGCTGGCCA	0.622000													9	18					0	0	0	0
CNGA3	1261	broad.mit.edu	37	2	99013493	99013493	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:99013493C>T	uc002syt.2	+	8	2277	c.1860C>T	c.(1858-1860)GGC>GGT	p.G620G	CNGA3_uc002syu.2_Silent_p.G602G|CNGA3_uc010fij.2_Silent_p.G624G	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	620					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CCAGGGCGGGCGCGGACCCCA	0.622000													3	17					0	0	0	0
EPB41L5	57669	broad.mit.edu	37	2	120925517	120925517	+	Missense_Mutation	SNP	A	C	C	rs143558813	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:120925517A>C	uc002tmg.2	+	24	2195	c.2069A>C	c.(2068-2070)CAT>CCT	p.H690P	EPB41L5_uc010fll.2_Intron|EPB41L5_uc010flm.2_Missense_Mutation_p.H493P	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	690						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AAGGAGGGACATGGTAATAAA	0.453000													5	100					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152539240	152539240	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:152539240C>G	uc010fnx.2	-	29	3070	c.2879G>C	c.(2878-2880)GGC>GCC	p.G960A		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	960	Nebulin 23.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGCACCCAGCCACAACCTTT	0.438000													3	19					0	0	0	0
HOXD3	3232	broad.mit.edu	37	2	177036312	177036312	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:177036312C>T	uc002ukt.1	+	3	785	c.609C>T	c.(607-609)AGC>AGT	p.S203S		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	203	Homeobox.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CATACACGAGCGCGCAGCTGG	0.642000													11	35					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216274717	216274717	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:216274717C>T	uc002vfa.2	-	14	2328	c.2062G>A	c.(2062-2064)GGC>AGC	p.G688S	FN1_uc002vfb.2_Missense_Mutation_p.G688S|FN1_uc002vfc.2_Missense_Mutation_p.G688S|FN1_uc002vfd.2_Missense_Mutation_p.G688S|FN1_uc002vfe.2_Missense_Mutation_p.G688S|FN1_uc002vff.2_Missense_Mutation_p.G688S|FN1_uc002vfg.2_Missense_Mutation_p.G688S|FN1_uc002vfh.2_Missense_Mutation_p.G688S|FN1_uc002vfi.2_Missense_Mutation_p.G688S|FN1_uc002vfj.2_Missense_Mutation_p.G688S	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	688	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTGGTGGCCGTACTGCTGG	0.552000													19	94					0	0	0	0
NHEJ1	79840	broad.mit.edu	37	2	220033735	220033735	+	Splice_Site	SNP	A	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:220033735A>T	uc002vjq.3	-	4		c.580_splice	c.e4+1		SLC23A3_uc010zkr.1_Intron|SLC23A3_uc010zks.1_Intron|SLC23A3_uc010fwb.2_Intron|SLC23A3_uc002vjs.1_Intron|SLC23A3_uc002vjt.1_Intron			Q9H9Q4	NHEJ1_HUMAN	Synthetic construct DNA, clone: pF1KE1061, Homo sapiens NHEJ1 gene for nonhomologous end-joining factor 1, without stop codon, in Flexi system.						B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		ATCCCTTCTCACCTCCAGATA	0.557000								Direct_reversal_of_damage|NHEJ					12	31					0	0	0	0
JAG1	182	broad.mit.edu	37	20	10630209	10630209	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:10630209C>T	uc002wnw.2	-	10	1825	c.1309G>A	c.(1309-1311)GAC>AAC	p.D437N	JAG1_uc010gcd.1_5'UTR	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	437	EGF-like 6; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GGAAGACAGTCGCAGTAGTAG	0.458000									Alagille_Syndrome				9	39					0	0	0	0
PCSK2	5126	broad.mit.edu	37	20	17434530	17434530	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:17434530C>T	uc002wpm.2	+	9	1349	c.1029C>T	c.(1027-1029)TAC>TAT	p.Y343Y	PCSK2_uc002wpl.2_Silent_p.Y324Y|PCSK2_uc010zrm.1_Silent_p.Y308Y	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	343	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity	p.Y343Y(1)		ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCCTGTACGACGAGAGCT	0.597000													24	50					0	0	0	0
CD93	22918	broad.mit.edu	37	20	23065975	23065975	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:23065975G>A	uc002wsv.2	-	1	1003	c.855C>T	c.(853-855)TGC>TGT	p.C285C		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	285	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTCGGCAGCCGCAGAGGAAGG	0.647000													18	125					0	0	0	0
MANBAL	63905	broad.mit.edu	37	20	35929759	35929759	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:35929759C>T	uc002xgu.2	+	3	305	c.93C>T	c.(91-93)ATC>ATT	p.I31I	MANBAL_uc002xgv.2_Silent_p.I31I|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	31	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(115;0.00878)				TGGGAGCCATCTTCCAGCTCA	0.602000													5	140					0	0	0	0
LPIN3	64900	broad.mit.edu	37	20	39978495	39978495	+	Silent	SNP	C	T	T	rs150401004	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:39978495C>T	uc002xjx.2	+	6	811	c.720C>T	c.(718-720)GCC>GCT	p.A240A	LPIN3_uc010ggh.2_Silent_p.A241A|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	240					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				CCCTAAGAGCCGAGTCCCACA	0.637000													12	58					0	0	0	0
WFDC8	90199	broad.mit.edu	37	20	44181876	44181876	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:44181876C>T	uc002xow.2	-	5	564	c.485G>A	c.(484-486)CGT>CAT	p.R162H	WFDC8_uc002xox.2_Missense_Mutation_p.R162H	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	162	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				ACACTCCTTACGTTCAGTGAA	0.488000													11	58					0	0	0	0
RRP1	8568	broad.mit.edu	37	21	45213246	45213246	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr21:45213246G>T	uc002zds.2	+	4	414	c.321G>T	c.(319-321)TGG>TGT	p.W107C	RRP1_uc011aez.1_Missense_Mutation_p.W107C|RRP1_uc010gpk.1_5'UTR|RRP1_uc010gpl.1_Missense_Mutation_p.W5C	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	107					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		ATCGCGAGTGGACGGGCATTG	0.612000													9	122					4.68919e-08	5.12153e-08	1	0
CABIN1	23523	broad.mit.edu	37	22	24480679	24480679	+	Missense_Mutation	SNP	G	C	C	rs35231087		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr22:24480679G>C	uc002zzi.1	+	21	3185	c.3058G>C	c.(3058-3060)GAG>CAG	p.E1020Q	CABIN1_uc002zzj.1_Missense_Mutation_p.E970Q|CABIN1_uc002zzl.1_Missense_Mutation_p.E1020Q	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1020					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCTCGCACAGAGAGGCCAGC	0.557000													21	66					0	0	0	0
CPNE9	151835	broad.mit.edu	37	3	9757188	9757188	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:9757188A>T	uc003bsd.2	+	12	971	c.800A>T	c.(799-801)AAG>ATG	p.K267M		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	267	Poly-Lys.									ovary(2)	2	Medulloblastoma(99;0.227)					TGTAAGAAGAAGAAATATGTC	0.433000													25	43					0	0	0	0
CPNE9	151835	broad.mit.edu	37	3	9757198	9757198	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:9757198C>T	uc003bsd.2	+	12	981	c.810C>T	c.(808-810)GTC>GTT	p.V270V		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	270										ovary(2)	2	Medulloblastoma(99;0.227)					AGAAATATGTCAACTCAGGAA	0.408000													21	35					0	0	0	0
TGM4	7047	broad.mit.edu	37	3	44952543	44952543	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:44952543C>T	uc003coc.3	+	12	1773	c.1700C>T	c.(1699-1701)GCG>GTG	p.A567V		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	567					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTCATCATTGCGGAAATTGTG	0.453000													14	61					0	0	0	0
SETD2	29072	broad.mit.edu	37	3	47098467	47098467	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:47098467A>C	uc003cqs.2	-	15	6860	c.6807T>G	c.(6805-6807)AAT>AAG	p.N2269K	SETD2_uc003cqv.2_Missense_Mutation_p.N2336K|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2269	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAACACTATAATTCTGTCCCT	0.512000			N|F|S|Mis		clear cell renal carcinoma								17	48					0	0	0	0
USP4	7375	broad.mit.edu	37	3	49362439	49362439	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:49362439T>G	uc003cwq.2	-	5	600	c.521A>C	c.(520-522)AAC>ACC	p.N174T	USP4_uc003cwr.2_Missense_Mutation_p.N174T	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	174					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGCAGGGATGTTGAATAGCTT	0.498000													21	109					0	0	0	0
TWF2	11344	broad.mit.edu	37	3	52263196	52263196	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:52263196C>T	uc003ddd.2	-	9	1055	c.904G>A	c.(904-906)GAG>AAG	p.E302K	TLR9_uc003ddb.2_Intron|TLR9_uc003ddc.1_Intron|TWF2_uc010hmc.2_3'UTR	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	302	ADF-H 2.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCCGTCAGCTCTGCCCCATCG	0.652000													4	60					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52941219	52941219	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:52941219C>G	uc003dgf.2	-	20	2766	c.2197G>C	c.(2197-2199)GAA>CAA	p.E733Q	SFMBT1_uc010hmr.2_Missense_Mutation_p.E680Q|SFMBT1_uc003dgg.2_Missense_Mutation_p.E733Q|SFMBT1_uc003dgh.2_Missense_Mutation_p.E733Q	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	733					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GACTTTTTTTCTGACATTTCT	0.463000													8	87					0	0	0	0
EPHA6	285220	broad.mit.edu	37	3	97202858	97202858	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:97202858G>C	uc010how.1	+	10	2198	c.2155G>C	c.(2155-2157)GAG>CAG	p.E719Q	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.E85Q|EPHA6_uc003drs.3_Missense_Mutation_p.E111Q|EPHA6_uc003drr.3_Missense_Mutation_p.E111Q|EPHA6_uc003drt.2_Missense_Mutation_p.E111Q|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	624	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.A719S(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATTTGCAAAGGAGATTGATCC	0.308000													10	25					0	0	0	0
IMPG2	50939	broad.mit.edu	37	3	100963246	100963246	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:100963246C>T	uc003duq.1	-	13	2132	c.1929G>A	c.(1927-1929)GAG>GAA	p.E643E	IMPG2_uc011bhe.1_Silent_p.E506E	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	643	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGTCTTCAATCTCAGCTGGCA	0.413000													28	90					0	0	0	0
PODXL2	50512	broad.mit.edu	37	3	127379692	127379692	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:127379692G>A	uc003ejq.2	+	3	845	c.821G>A	c.(820-822)GGG>GAG	p.G274E		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	274	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CCAGCTGCAGGGCTTGGGGTA	0.637000													7	45					0	0	0	0
EEFSEC	60678	broad.mit.edu	37	3	128127010	128127010	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:128127010G>A	uc003eki.2	+	7	1737	c.1699G>A	c.(1699-1701)GAG>AAG	p.E567K	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	567						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGAGAGCGCCGAGCGGAGCGA	0.647000													3	43					0	0	0	0
IFT122	55764	broad.mit.edu	37	3	129180117	129180117	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:129180117C>T	uc003emm.2	+	5	525	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	IFT122_uc003eml.2_Nonsense_Mutation_p.Q158*|IFT122_uc003emn.2_Nonsense_Mutation_p.Q107*|IFT122_uc003emo.2_Intron|IFT122_uc003emp.2_5'UTR|IFT122_uc010htc.2_Nonsense_Mutation_p.Q158*|IFT122_uc011bky.1_5'UTR|IFT122_uc003emq.2_Intron|IFT122_uc003emr.2_5'Flank|IFT122_uc011bla.1_5'Flank|IFT122_uc011bkx.1_Intron|IFT122_uc011bkz.1_5'Flank	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	107	WD 3.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						TATTACTCATCAACTGGCATC	0.398000													15	53					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178937422	178937422	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:178937422T>C	uc003fjk.2	+	12	1967	c.1810T>C	c.(1810-1812)TGT>CGT	p.C604R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	604	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACTTCTGGACTGTAATTACCC	0.368000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	35					0	0	0	0
DVL3	1857	broad.mit.edu	37	3	183882981	183882981	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:183882981C>T	uc003fms.2	+	6	820	c.680C>T	c.(679-681)TCT>TTT	p.S227F	DVL3_uc011bqw.1_Missense_Mutation_p.S227F|DVL3_uc003fmt.2_5'UTR|DVL3_uc003fmu.2_Missense_Mutation_p.S59F	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	227					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CAGAAGGTTTCTCGGATTGAG	0.597000													13	30					0	0	0	0
ZNF718	255403	broad.mit.edu	37	4	154749	154749	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:154749G>C	uc003fzt.3	+	8	407	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		GCAGGGCATAGAAGATTCATT	0.328000													9	39					0	0	0	0
LOC348926	348926	broad.mit.edu	37	4	3948570	3948570	+	RNA	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:3948570G>A	uc011bvu.1	-	5		c.1765C>T			LOC348926_uc003ghn.2_Intron	NR_024253				Homo sapiens hypothetical protein LOC348926, mRNA (cDNA clone IMAGE:4546485), partial cds.												0						GGAGCCCGCTGGTGCTCCCGG	0.622000													3	44					0	0	0	0
WFS1	7466	broad.mit.edu	37	4	6303197	6303197	+	Missense_Mutation	SNP	G	A	A	rs55814513	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:6303197G>A	uc003giy.2	+	8	1841	c.1675G>A	c.(1675-1677)GCC>ACC	p.A559T	WFS1_uc003gix.2_Missense_Mutation_p.A559T|WFS1_uc003giz.2_Missense_Mutation_p.A377T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	559					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GCTGCTCCGCGCCTCCATCGG	0.652000													6	100					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24488189	24488189	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:24488189G>C	uc003jgr.1	-	12	2282	c.1950C>G	c.(1948-1950)ATC>ATG	p.I650M	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	650	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGTTGTCTCTGATATCTTCTT	0.428000										HNSCC(23;0.051)			6	51					0	0	0	0
SV2C	22987	broad.mit.edu	37	5	75427937	75427937	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:75427937G>A	uc003kei.1	+	2	496	c.362G>A	c.(361-363)CGG>CAG	p.R121Q		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	121	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		AAGGACCGGCGGGAGCTGGAA	0.547000													7	49					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140180884	140180884	+	Silent	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:140180884C>A	uc003lhf.2	+	1	102	c.102C>A	c.(100-102)TCC>TCA	p.S34S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S34S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCACTACTCCGTCTCTGAGG	0.667000													26	73					1.85244e-09	2.06722e-09	1	0
PCDHB14	56122	broad.mit.edu	37	5	140605383	140605383	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:140605383C>A	uc003ljb.2	+	1	2306	c.2306C>A	c.(2305-2307)CCG>CAG	p.P769Q	PCDHB14_uc011dal.1_Missense_Mutation_p.P616Q	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	769	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCTGAAGCCGATTATCCCC	0.453000													8	90					5.4927e-09	6.04197e-09	1	0
SLIT3	6586	broad.mit.edu	37	5	168112816	168112816	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:168112816C>T	uc003mab.2	-	31	3851	c.3431G>A	c.(3430-3432)CGC>CAC	p.R1144H	SLIT3_uc010jjg.2_Missense_Mutation_p.R1151H	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1144	EGF-like 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGTGGGCAGCGGCAGGTGGG	0.647000													4	20					0	0	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179321452	179321452	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:179321452G>A	uc003mlh.2	-	4	548	c.511C>T	c.(511-513)CGG>TGG	p.R171W	TBC1D9B_uc003mli.2_Missense_Mutation_p.R171W|TBC1D9B_uc003mlj.2_Missense_Mutation_p.R171W	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	171	GRAM 1.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCCCTGCCGGGGCACGCGG	0.627000													3	41					0	0	0	0
SLC39A7	7922	broad.mit.edu	37	6	33169860	33169860	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:33169860C>G	uc003odf.2	+	4	709	c.592C>G	c.(592-594)CAC>GAC	p.H198D	RXRB_uc003odb.2_5'Flank|RXRB_uc003odc.2_5'Flank|RXRB_uc003odd.2_5'Flank|RXRB_uc011dqr.1_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.2_Missense_Mutation_p.H198D|SLC39A7_uc011dqv.1_Missense_Mutation_p.H73D|SLC39A7_uc003odh.2_5'Flank|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	198						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						ACCTCATTCTCACCACACTCT	0.527000													13	68					0	0	0	0
DAXX	1616	broad.mit.edu	37	6	33288181	33288181	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:33288181G>A	uc003oec.2	-	4	1431	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.P334P|DAXX_uc011dre.1_Silent_p.P421P|DAXX_uc003oed.2_Silent_p.P409P|DAXX_uc010juw.2_Silent_p.P334P	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	409	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						AGGAGGCTTCGGGGGTGTCTG	0.542000			Mis|F|N		Pancreatic neuroendocrine tumors								4	85					0	0	0	0
FILIP1	27145	broad.mit.edu	37	6	76024909	76024909	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:76024909C>A	uc003pia.2	-	5	1012	c.639G>T	c.(637-639)AAG>AAT	p.K213N	FILIP1_uc003phy.1_Missense_Mutation_p.K213N|FILIP1_uc003phz.2_Missense_Mutation_p.K114N|FILIP1_uc010kbe.2_Missense_Mutation_p.K216N|FILIP1_uc003pib.1_5'UTR	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	213	Potential.									skin(3)|ovary(1)	4						GTTCAAGGAGCTTTTTTAACC	0.299000													7	29					8.12818e-05	8.63269e-05	1	0
SOBP	55084	broad.mit.edu	37	6	107854757	107854757	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:107854757C>T	uc003prx.2	+	4	1020	c.516C>T	c.(514-516)AGC>AGT	p.S172S	SOBP_uc003prw.1_Silent_p.S172S	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	172	FCS-type 1.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		AGGTGAAAAGCTTCTGCAGCG	0.512000													31	115					0	0	0	0
SOBP	55084	broad.mit.edu	37	6	107854759	107854759	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:107854759T>G	uc003prx.2	+	4	1022	c.518T>G	c.(517-519)TTC>TGC	p.F173C	SOBP_uc003prw.1_Missense_Mutation_p.F173C	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	173	FCS-type 1.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GTGAAAAGCTTCTGCAGCGAG	0.517000													29	115					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112441515	112441515	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:112441515C>T	uc003pvu.2	-	33	4945	c.4636G>A	c.(4636-4638)GAG>AAG	p.E1546K	LAMA4_uc003pvv.2_Missense_Mutation_p.E1539K|LAMA4_uc003pvt.2_Missense_Mutation_p.E1539K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1546	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTGTATTTCTCCTGGCTTCTA	0.418000													21	68					0	0	0	0
IGF2R	3482	broad.mit.edu	37	6	160453983	160453983	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:160453983A>G	uc003qta.2	+	9	1203	c.1055A>G	c.(1054-1056)TAT>TGT	p.Y352C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	352	Lumenal (Potential).|3.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GGTTCATCCTATATTTCAGAT	0.308000													21	74					0	0	0	0
UNC93A	54346	broad.mit.edu	37	6	167728857	167728857	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:167728857G>A	uc003qvq.2	+	8	1466	c.1291G>A	c.(1291-1293)GTG>ATG	p.V431M	UNC93A_uc003qvr.2_Missense_Mutation_p.V389M	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	431						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGTGGAGTGCGTGGAGTCCAA	0.547000													21	306					0	0	0	0
DLL1	28514	broad.mit.edu	37	6	170594698	170594698	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:170594698C>T	uc003qxm.2	-	6	1291	c.821G>A	c.(820-822)TGC>TAC	p.C274Y		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	274	Extracellular (Potential).|EGF-like 2.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CTGGCAGTTGCACTGCCAGGG	0.627000													23	45					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4116798	4116798	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:4116798C>T	uc003smx.2	+	21	3318	c.3179C>T	c.(3178-3180)ACC>ATC	p.T1060I	SDK1_uc010kso.2_Missense_Mutation_p.T336I	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1060	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACTTCATCCACCATTTCTTCT	0.562000													6	27					0	0	0	0
EPO	2056	broad.mit.edu	37	7	100320671	100320671	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:100320671G>A	uc003uwi.2	+	5	678	c.497G>A	c.(496-498)CGC>CAC	p.R166H	EPO_uc011kkc.1_Missense_Mutation_p.R165H	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	166					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GACACTTTCCGCAAACTCTTC	0.572000													28	134					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103132413	103132413	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:103132413T>C	uc003vca.2	-	58	9590	c.9430A>G	c.(9430-9432)ACT>GCT	p.T3144A	RELN_uc010liz.2_Missense_Mutation_p.T3144A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3144	BNR 15.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCATCCTTAGTGTATTCCAGC	0.303000													7	16					0	0	0	0
NUP205	23165	broad.mit.edu	37	7	135323426	135323426	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:135323426G>A	uc003vsw.2	+	38	5418	c.5387G>A	c.(5386-5388)CGG>CAG	p.R1796Q	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1796					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GATGGACCGCGGCAAGGTGAG	0.438000													43	108					0	0	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919983	142919983	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:142919983T>C	uc011ksx.1	+	1	812	c.812T>C	c.(811-813)TTT>TCT	p.F271S		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	271	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TCCAACATCTTTGACACTTAC	0.473000													33	86					0	0	0	0
TPD52	7163	broad.mit.edu	37	8	80954859	80954859	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr8:80954859A>T	uc003ybr.1	-	5	873	c.551T>A	c.(550-552)TTA>TAA	p.L184*	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Nonsense_Mutation_p.L167*|TPD52_uc003ybt.1_Nonsense_Mutation_p.L144*|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	184					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			ACTTGCCTTTAAGTTTTCGAC	0.308000													22	67					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103359220	103359220	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr8:103359220T>A	uc003ykr.1	-	6	520	c.487A>T	c.(487-489)ACA>TCA	p.T163S	UBR5_uc003yks.1_Missense_Mutation_p.T163S	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	163					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCCCGTCCTGTCCGAATAACT	0.567000													24	197					0	0	0	0
INSL4	3641	broad.mit.edu	37	9	5233770	5233770	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:5233770A>C	uc003ziy.2	+	2	418	c.313A>C	c.(313-315)AAG>CAG	p.K105Q		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	105					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GCCATCATTGAAGAAAATAAT	0.393000													4	66					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625382	43625382	+	Missense_Mutation	SNP	G	A	A	rs143826416	by1000genomes	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:43625382G>A	uc011lrb.1	-	4	3334	c.3305C>T	c.(3304-3306)CCT>CTT	p.P1102L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1102						integral to membrane					0						CTTGTGAATAGGGGGAAACAT	0.483000													7	227					0	0	0	0
ZNF322B	387328	broad.mit.edu	37	9	99961655	99961655	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:99961655C>T	uc004axd.1	-	1	256	c.139G>A	c.(139-141)GAA>AAA	p.E47K	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				TGCTTGCATTCAAGGCACTGG	0.338000													11	303					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	119093591	119093591	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:119093591C>T	uc004bjn.2	+	11	3597	c.3216C>T	c.(3214-3216)ATC>ATT	p.I1072I	PAPPA_uc011lxp.1_Silent_p.I767I|PAPPA_uc011lxq.1_Silent_p.I447I	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1072					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CTTGCACCATCAGCTACCCAT	0.473000													26	65					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32380945	32380945	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:32380945T>C	uc004dda.1	-	37	5529	c.5285A>G	c.(5284-5286)CAT>CGT	p.H1762R	DMD_uc004dcw.2_Missense_Mutation_p.H418R|DMD_uc004dcx.2_Missense_Mutation_p.H421R|DMD_uc004dcz.2_Missense_Mutation_p.H1639R|DMD_uc004dcy.1_Missense_Mutation_p.H1758R|DMD_uc004ddb.1_Missense_Mutation_p.H1754R|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1762	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCAAATCGATGGTTGAGCTC	0.483000													30	103					0	0	0	0
ZXDA	7789	broad.mit.edu	37	X	57935933	57935933	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:57935933C>T	uc004dve.2	-	1	1135	c.922G>A	c.(922-924)GGC>AGC	p.G308S		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	308	Required for interaction with ZXDC.|C2H2-type 2.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AAGGTCCAGCCGCAGCCACCC	0.627000													7	24					0	0	0	0
COL4A6	1288	broad.mit.edu	37	X	107417817	107417817	+	Silent	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:107417817T>C	uc004enw.3	-	31	3097	c.2994A>G	c.(2992-2994)CCA>CCG	p.P998P	COL4A6_uc004env.3_Silent_p.P997P|COL4A6_uc011msn.1_Silent_p.P997P|COL4A6_uc010npk.2_Silent_p.P997P	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	998	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CAGGTAGGCCTGGTGGTCCAG	0.537000									Alport_syndrome_with_Diffuse_Leiomyomatosis				17	45					0	0	0	0
ZNF449	203523	broad.mit.edu	37	X	134483215	134483215	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:134483215G>T	uc004eys.2	+	3	700	c.535G>T	c.(535-537)GAA>TAA	p.E179*	ZNF449_uc004eyq.1_3'UTR|ZNF449_uc004eyt.2_Nonsense_Mutation_p.E59*	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	179					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTACTGGAGAATGTCAGAA	0.537000													10	99					7.48243e-07	8.058e-07	1	0
SLC9A6	10479	broad.mit.edu	37	X	135106627	135106627	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:135106627C>T	uc004ezj.2	+	12	1581	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	SLC9A6_uc004ezk.2_Missense_Mutation_p.S534L	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	502	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCAATGCTGTCATGCTTGCAT	0.378000													19	119					0	0	0	0
TREX2	11219	broad.mit.edu	37	X	152710829	152710829	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:152710829G>A	uc010nue.1	-	3	302	c.186C>T	c.(184-186)CTC>CTT	p.L62L	TREX2_uc010nud.1_Silent_p.L20L|TREX2_uc011myp.1_Silent_p.L20L|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	63					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACACTGGGGAGCCCAGTGG	0.622000								Editing_and_processing_nucleases					5	6					0	0	0	0
FAM3A	60343	broad.mit.edu	37	X	153740200	153740200	+	Silent	SNP	T	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:153740200T>A	uc004fls.1	-	3	409	c.132A>T	c.(130-132)CCA>CCT	p.P44P	FAM3A_uc004flt.1_Silent_p.P58P|FAM3A_uc011mzp.1_Silent_p.P44P|FAM3A_uc004flu.1_Silent_p.P58P|FAM3A_uc011mzq.1_Silent_p.P44P|FAM3A_uc004flw.1_Silent_p.P44P	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	44						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGAGCTCTCTGGACCTGTGG	0.632000											OREG0003614	type=REGULATORY REGION|Gene=FAM3A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	36					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19478948	19478948	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr1:19478948C>T	uc001bbi.2	-	47	6859	c.6855G>A	c.(6853-6855)GTG>GTA	p.V2285V	UBR4_uc001bbk.1_5'Flank|UBR4_uc001bbl.1_Silent_p.V222V|UBR4_uc001bbm.1_Silent_p.V1497V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2285					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGGAAAGTCACCTGGCTAG	0.507000													8	153					0	0	0	0
PTGFR	5737	broad.mit.edu	37	1	78958948	78958948	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr1:78958948C>T	uc001din.2	+	2	786	c.520C>T	c.(520-522)CAT>TAT	p.H174Y	PTGFR_uc001dim.2_Missense_Mutation_p.H174Y	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	174	Helical; Name=4; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CATCCTTGGACATCGAGACTA	0.368000													11	131					0	0	0	0
WDR63	126820	broad.mit.edu	37	1	85560225	85560225	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr1:85560225C>T	uc001dkt.2	+	10	1351	c.1160C>T	c.(1159-1161)CCT>CTT	p.P387L	WDR63_uc009wcl.2_Missense_Mutation_p.P348L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	387										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TTCTCTGATCCTATACATCCT	0.383000													6	183					0	0	0	0
CLCA4	22802	broad.mit.edu	37	1	87031654	87031654	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr1:87031654T>C	uc009wcs.2	+	6	949	c.905T>C	c.(904-906)ATC>ACC	p.I302T	CLCA4_uc009wct.2_Missense_Mutation_p.I65T|CLCA4_uc009wcu.2_Missense_Mutation_p.I122T	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	302						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTGCTGAAGATCAGTCAAAGA	0.413000													25	84					0	0	0	0
NBPF15	284565	broad.mit.edu	37	1	148594513	148594513	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr1:148594513G>A	uc001esc.2	+	19	2375	c.1886G>A	c.(1885-1887)AGA>AAA	p.R629K		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	629	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					CAGCACTACAGAAGTGTGTTT	0.438000													18	421					0	0	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511852	72511852	+	Silent	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr10:72511852G>T	uc001jrh.2	+	18	2598	c.2598G>T	c.(2596-2598)GGG>GGT	p.G866G	ADAMTS14_uc001jrg.2_Silent_p.G869G	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	866	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCCCATAGGGATCCAGTTCA	0.662000													8	20					0.00307968	0.0032652	1	0
JAKMIP3	282973	broad.mit.edu	37	10	133962932	133962932	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr10:133962932C>T	uc001lkx.3	+	14	1865	c.1865C>T	c.(1864-1866)TCA>TTA	p.S622L	JAKMIP3_uc009yba.1_Missense_Mutation_p.S59L	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAGAGGAAGTCACCCGCCATC	0.647000													6	12					0	0	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537578	5537578	+	Missense_Mutation	SNP	G	C	C	rs140401116		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr11:5537578G>C	uc001maz.3	-	1	379	c.94C>G	c.(94-96)CGA>GGA	p.R32G	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	32	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		ACTATCACTCGAGTGGCACTT	0.483000													4	91					0	0	0	0
KIF18A	81930	broad.mit.edu	37	11	28084055	28084055	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr11:28084055C>A	uc001msc.2	-	12	1781	c.1599G>T	c.(1597-1599)AAG>AAT	p.K533N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	533					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						GAAGATCTTTCTTGAGTTCCT	0.323000													22	49					4.4004e-07	4.96456e-07	1	0
ANO1	55107	broad.mit.edu	37	11	70007358	70007358	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr11:70007358G>A	uc001opj.2	+	17	1975	c.1670G>A	c.(1669-1671)CGG>CAG	p.R557Q	ANO1_uc001opk.1_Missense_Mutation_p.R499Q|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.R266Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	557	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCCTCCGTGCGGTCCAACATC	0.592000													23	69					0	0	0	0
FZD4	8322	broad.mit.edu	37	11	86662820	86662820	+	Silent	SNP	A	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr11:86662820A>G	uc001pce.2	-	2	1284	c.978T>C	c.(976-978)ACT>ACC	p.T326T	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	326	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCAAAAACCAAGTGAGTGTCA	0.453000													4	22					0	0	0	0
FKBP4	2288	broad.mit.edu	37	12	2909727	2909727	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr12:2909727T>C	uc001qkz.2	+	8	1214	c.1016T>C	c.(1015-1017)ATT>ACT	p.I339T		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	339	TPR 2.|Interaction with tubulin (By similarity).				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	TCTGCTGCCATTGAAAGCTGT	0.532000													9	39					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53680134	53680134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr12:53680134C>T	uc001sck.2	+	18	3705	c.3614C>T	c.(3613-3615)TCC>TTC	p.S1205F	ESPL1_uc001scj.2_Missense_Mutation_p.S880F|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1205					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTCCAAGCTTCCCTGAATCAT	0.587000													28	99					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57571375	57571375	+	Splice_Site	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr12:57571375G>T	uc001snd.2	+	26	4827	c.4361_splice	c.e26+1	p.R1454_splice		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGACGCCAGGTCAGCACCCT	0.652000													9	19					2.74318e-10	3.26216e-10	1	0
LRIG3	121227	broad.mit.edu	37	12	59272720	59272720	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr12:59272720C>A	uc001sqr.2	-	14	2215	c.1969G>T	c.(1969-1971)GAG>TAG	p.E657*	LRIG3_uc009zqh.2_Nonsense_Mutation_p.E597*|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	657	Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			ACGTCATCCTCGGGCATCACA	0.552000													9	95					0.000274275	0.000294344	1	0
MDGA2	161357	broad.mit.edu	37	14	47530570	47530570	+	Silent	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr14:47530570T>C	uc001wwj.3	-	7	1396	c.1200A>G	c.(1198-1200)ACA>ACG	p.T400T	MDGA2_uc001wwi.3_Silent_p.T171T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	400	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGTCCAAGTTTGTTGTTCCCG	0.403000													8	182					0	0	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68050595	68050596	+	Silent	DNP	GC	AT	AT			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr14:68050595_68050596GC>AT	uc001xjl.1	+	25	3706_3707	c.3564_3565GC>AT	c.(3562-3567)CAGCTG>CAATTG	p.1188_1189QL>QL	PLEKHH1_uc010tsw.1_Silent_p.756_757QL>QL|PLEKHH1_uc001xjn.1_Silent_p.703_704QL>QL|PLEKHH1_uc010tsx.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjo.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjp.1_Silent_p.53_54QL>QL	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	1188_1189	FERM.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCGCTGAACAGCTGAGGTAGGT	0.584000											OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257020	69257020	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr14:69257020C>G	uc001xkh.1	-	2	377	c.247G>C	c.(247-249)GAC>CAC	p.D83H	ZFP36L1_uc001xki.1_Missense_Mutation_p.D83H	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	83					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AAGCGGCTGTCTCGCGAGCTC	0.682000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	31					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88934592	88934592	+	Missense_Mutation	SNP	T	G	G	rs151002751	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr14:88934592T>G	uc001xwv.3	-	19	3745	c.3414A>C	c.(3412-3414)AGA>AGC	p.R1138S	PTPN21_uc010twc.1_Missense_Mutation_p.R934S	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1138	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TGTCCAGCACTCTCGGGATGT	0.512000													5	133					0	0	0	0
ADSSL1	122622	broad.mit.edu	37	14	105201381	105201381	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr14:105201381G>T	uc001ypd.2	+	2	291	c.217G>T	c.(217-219)GTG>TTG	p.V73L	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.V116L|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	73					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CGGCCACACGGTGGTGGTGGA	0.627000													4	21					0.00909568	0.00952881	1	0
DUOX1	53905	broad.mit.edu	37	15	45428812	45428812	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr15:45428812C>T	uc001zus.1	+	10	1357	c.1011C>T	c.(1009-1011)GGC>GGT	p.G337G	DUOX1_uc001zut.1_Silent_p.G337G|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	337	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TGCCCCCTGGCGTCTACATGA	0.592000													11	52					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50867173	50867173	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr15:50867173G>A	uc001zyt.3	-	34	5159	c.4895C>T	c.(4894-4896)ACC>ATC	p.T1632I	TRPM7_uc001zyr.2_Missense_Mutation_p.T69I	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1632	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTCTGACCAGGTACACTGTAC	0.388000													33	115					0	0	0	0
PDXDC1	23042	broad.mit.edu	37	16	15110041	15110041	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr16:15110041G>C	uc002dda.3	+	9	1007	c.783G>C	c.(781-783)GAG>GAC	p.E261D	PDXDC1_uc010uzl.1_Missense_Mutation_p.E246D|PDXDC1_uc010uzm.1_Missense_Mutation_p.E170D|PDXDC1_uc002dcz.2_Missense_Mutation_p.E238D|PDXDC1_uc002ddb.3_Missense_Mutation_p.E234D|PDXDC1_uc010uzn.1_Missense_Mutation_p.E233D|PDXDC1_uc002ddc.2_Missense_Mutation_p.E261D	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	261					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	AACTCTGTGAGCAGTATGGCA	0.502000													8	55					0	0	0	0
KCNG4	93107	broad.mit.edu	37	16	84270496	84270496	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr16:84270496C>T	uc010voc.1	-	2	717	c.596G>A	c.(595-597)CGC>CAC	p.R199H	KCNG4_uc002fhu.1_Missense_Mutation_p.R199H	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	199						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGGCCCCAGCGCGAGGAGTG	0.677000													15	36					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	24					0	0	0	0
KRT14	3861	broad.mit.edu	37	17	39740142	39740142	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr17:39740142C>G	uc002hxf.1	-	4	858	c.797G>C	c.(796-798)GGA>GCA	p.G266A	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.G266A	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	266	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				ATTGACATCTCCACCCACCTG	0.577000													9	108					0	0	0	0
SGCA	6442	broad.mit.edu	37	17	48245850	48245850	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr17:48245850C>T	uc002iqi.2	+	5	537	c.501C>T	c.(499-501)CCC>CCT	p.P167P	SGCA_uc010wmh.1_Silent_p.P65P|SGCA_uc002iqj.2_Silent_p.P167P|SGCA_uc010wmi.1_RNA|uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	167	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						TCTGGGAGCCCGGAGAGCTTC	0.642000													5	1					0	0	0	0
GNAL	2774	broad.mit.edu	37	18	11872355	11872355	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr18:11872355G>C	uc010dkz.2	+	11	1135	c.889G>C	c.(889-891)GAC>CAC	p.D297H	GNAL_uc002kqc.2_Missense_Mutation_p.D374H|GNAL_uc002kqd.2_Missense_Mutation_p.D297H|GNAL_uc010wzt.1_Missense_Mutation_p.D90H	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	297					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						AAAAATTGAAGACTATTTCCC	0.333000													24	71					0	0	0	0
OR10H1	26539	broad.mit.edu	37	19	15918404	15918404	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr19:15918404G>A	uc002nbq.2	-	1	533	c.444C>T	c.(442-444)TCC>TCT	p.S148S		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCAGCCCAGGAGCAGCCCA	0.632000													4	82					0	0	0	0
ZNF100	163227	broad.mit.edu	37	19	21909496	21909496	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr19:21909496G>C	uc002nqi.2	-	5	1817	c.1618C>G	c.(1618-1620)CTA>GTA	p.L540V	ZNF100_uc002nqh.2_Missense_Mutation_p.L476V	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACATTTGTAGGGTTTCTCTC	0.363000													3	44					0	0	0	0
HIPK4	147746	broad.mit.edu	37	19	40887043	40887043	+	Silent	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr19:40887043G>C	uc002onp.2	-	3	1140	c.855C>G	c.(853-855)CTC>CTG	p.L285L		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	285	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCAACGACTTGAGCATATACT	0.632000													12	34					0	0	0	0
VIT	5212	broad.mit.edu	37	2	37028521	37028521	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr2:37028521C>T	uc002rpl.2	+	13	1357	c.1136C>T	c.(1135-1137)ACT>ATT	p.T379I	VIT_uc002rpm.2_Missense_Mutation_p.T357I|VIT_uc010ezv.2_Missense_Mutation_p.T335I|VIT_uc010ezw.2_Missense_Mutation_p.T336I	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	364	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GAGAAAATTACTCAGAGAGGA	0.393000													13	167					0	0	0	0
CNGA3	1261	broad.mit.edu	37	2	99013475	99013475	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr2:99013475G>A	uc002syt.2	+	8	2259	c.1842G>A	c.(1840-1842)GAG>GAA	p.E614E	CNGA3_uc002syu.2_Silent_p.E596E|CNGA3_uc010fij.2_Silent_p.E618E	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	614					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGATCGATGAGGAGCTGGCCA	0.622000													9	18					0	0	0	0
EPB41L5	57669	broad.mit.edu	37	2	120925517	120925517	+	Missense_Mutation	SNP	A	C	C	rs143558813	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr2:120925517A>C	uc002tmg.2	+	24	2195	c.2069A>C	c.(2068-2070)CAT>CCT	p.H690P	EPB41L5_uc010fll.2_Intron|EPB41L5_uc010flm.2_Missense_Mutation_p.H493P	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	690						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AAGGAGGGACATGGTAATAAA	0.453000													5	100					0	0	0	0
HOXD3	3232	broad.mit.edu	37	2	177036312	177036312	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr2:177036312C>T	uc002ukt.1	+	3	785	c.609C>T	c.(607-609)AGC>AGT	p.S203S		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	203	Homeobox.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CATACACGAGCGCGCAGCTGG	0.642000													11	35					0	0	0	0
JAG1	182	broad.mit.edu	37	20	10630209	10630209	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr20:10630209C>T	uc002wnw.2	-	10	1825	c.1309G>A	c.(1309-1311)GAC>AAC	p.D437N	JAG1_uc010gcd.1_5'UTR	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	437	EGF-like 6; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GGAAGACAGTCGCAGTAGTAG	0.458000									Alagille_Syndrome				9	39					0	0	0	0
PCSK2	5126	broad.mit.edu	37	20	17434530	17434530	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr20:17434530C>T	uc002wpm.2	+	9	1349	c.1029C>T	c.(1027-1029)TAC>TAT	p.Y343Y	PCSK2_uc002wpl.2_Silent_p.Y324Y|PCSK2_uc010zrm.1_Silent_p.Y308Y	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	343	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity	p.Y343Y(1)		ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCCTGTACGACGAGAGCT	0.597000													24	50					0	0	0	0
MANBAL	63905	broad.mit.edu	37	20	35929759	35929759	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr20:35929759C>T	uc002xgu.2	+	3	305	c.93C>T	c.(91-93)ATC>ATT	p.I31I	MANBAL_uc002xgv.2_Silent_p.I31I|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	31	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(115;0.00878)				TGGGAGCCATCTTCCAGCTCA	0.602000													5	140					0	0	0	0
WFDC8	90199	broad.mit.edu	37	20	44181876	44181876	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr20:44181876C>T	uc002xow.2	-	5	564	c.485G>A	c.(484-486)CGT>CAT	p.R162H	WFDC8_uc002xox.2_Missense_Mutation_p.R162H	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	162	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				ACACTCCTTACGTTCAGTGAA	0.488000													11	58					0	0	0	0
RRP1	8568	broad.mit.edu	37	21	45213246	45213246	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr21:45213246G>T	uc002zds.2	+	4	414	c.321G>T	c.(319-321)TGG>TGT	p.W107C	RRP1_uc011aez.1_Missense_Mutation_p.W107C|RRP1_uc010gpk.1_5'UTR|RRP1_uc010gpl.1_Missense_Mutation_p.W5C	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	107					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		ATCGCGAGTGGACGGGCATTG	0.612000													9	122					4.68919e-08	5.35907e-08	1	0
CPNE9	151835	broad.mit.edu	37	3	9757188	9757188	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:9757188A>T	uc003bsd.2	+	12	971	c.800A>T	c.(799-801)AAG>ATG	p.K267M		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	267	Poly-Lys.									ovary(2)	2	Medulloblastoma(99;0.227)					TGTAAGAAGAAGAAATATGTC	0.433000													25	43					0	0	0	0
CPNE9	151835	broad.mit.edu	37	3	9757198	9757198	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:9757198C>T	uc003bsd.2	+	12	981	c.810C>T	c.(808-810)GTC>GTT	p.V270V		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	270										ovary(2)	2	Medulloblastoma(99;0.227)					AGAAATATGTCAACTCAGGAA	0.408000													21	35					0	0	0	0
TWF2	11344	broad.mit.edu	37	3	52263196	52263196	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:52263196C>T	uc003ddd.2	-	9	1055	c.904G>A	c.(904-906)GAG>AAG	p.E302K	TLR9_uc003ddb.2_Intron|TLR9_uc003ddc.1_Intron|TWF2_uc010hmc.2_3'UTR	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	302	ADF-H 2.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCCGTCAGCTCTGCCCCATCG	0.652000													4	60					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52941219	52941219	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:52941219C>G	uc003dgf.2	-	20	2766	c.2197G>C	c.(2197-2199)GAA>CAA	p.E733Q	SFMBT1_uc010hmr.2_Missense_Mutation_p.E680Q|SFMBT1_uc003dgg.2_Missense_Mutation_p.E733Q|SFMBT1_uc003dgh.2_Missense_Mutation_p.E733Q	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	733					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GACTTTTTTTCTGACATTTCT	0.463000													8	87					0	0	0	0
EPHA6	285220	broad.mit.edu	37	3	97202858	97202858	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:97202858G>C	uc010how.1	+	10	2198	c.2155G>C	c.(2155-2157)GAG>CAG	p.E719Q	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.E85Q|EPHA6_uc003drs.3_Missense_Mutation_p.E111Q|EPHA6_uc003drr.3_Missense_Mutation_p.E111Q|EPHA6_uc003drt.2_Missense_Mutation_p.E111Q|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	624	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.A719S(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATTTGCAAAGGAGATTGATCC	0.308000													10	25					0	0	0	0
IMPG2	50939	broad.mit.edu	37	3	100963246	100963246	+	Silent	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:100963246C>T	uc003duq.1	-	13	2132	c.1929G>A	c.(1927-1929)GAG>GAA	p.E643E	IMPG2_uc011bhe.1_Silent_p.E506E	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	643	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGTCTTCAATCTCAGCTGGCA	0.413000													28	90					0	0	0	0
PODXL2	50512	broad.mit.edu	37	3	127379692	127379692	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:127379692G>A	uc003ejq.2	+	3	845	c.821G>A	c.(820-822)GGG>GAG	p.G274E		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	274	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CCAGCTGCAGGGCTTGGGGTA	0.637000													7	45					0	0	0	0
EEFSEC	60678	broad.mit.edu	37	3	128127010	128127010	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:128127010G>A	uc003eki.2	+	7	1737	c.1699G>A	c.(1699-1701)GAG>AAG	p.E567K	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	567						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGAGAGCGCCGAGCGGAGCGA	0.647000													3	43					0	0	0	0
DVL3	1857	broad.mit.edu	37	3	183882981	183882981	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:183882981C>T	uc003fms.2	+	6	820	c.680C>T	c.(679-681)TCT>TTT	p.S227F	DVL3_uc011bqw.1_Missense_Mutation_p.S227F|DVL3_uc003fmt.2_5'UTR|DVL3_uc003fmu.2_Missense_Mutation_p.S59F	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	227					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CAGAAGGTTTCTCGGATTGAG	0.597000													13	30					0	0	0	0
SDHAP1	255812	broad.mit.edu	37	3	195690286	195690286	+	Missense_Mutation	SNP	C	G	G	rs138082028	by1000genomes	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr3:195690286C>G	uc003fvy.2	-	4	364	c.250G>C	c.(250-252)GTG>CTG	p.V84L	SDHAP1_uc003fvx.3_RNA					Homo sapiens full length insert cDNA clone ZC24D06.												0						CTATATTCCACAGTGACCTTG	0.393000													3	50					0	0	0	0
ZNF718	255403	broad.mit.edu	37	4	154749	154749	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr4:154749G>C	uc003fzt.3	+	8	407	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		GCAGGGCATAGAAGATTCATT	0.328000													9	39					0	0	0	0
LOC348926	348926	broad.mit.edu	37	4	3948570	3948570	+	RNA	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr4:3948570G>A	uc011bvu.1	-	5		c.1765C>T			LOC348926_uc003ghn.2_Intron	NR_024253				Homo sapiens hypothetical protein LOC348926, mRNA (cDNA clone IMAGE:4546485), partial cds.												0						GGAGCCCGCTGGTGCTCCCGG	0.622000													3	44					0	0	0	0
WFS1	7466	broad.mit.edu	37	4	6303197	6303197	+	Missense_Mutation	SNP	G	A	A	rs55814513	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr4:6303197G>A	uc003giy.2	+	8	1841	c.1675G>A	c.(1675-1677)GCC>ACC	p.A559T	WFS1_uc003gix.2_Missense_Mutation_p.A559T|WFS1_uc003giz.2_Missense_Mutation_p.A377T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	559					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GCTGCTCCGCGCCTCCATCGG	0.652000													6	100					0	0	0	0
SV2C	22987	broad.mit.edu	37	5	75427937	75427937	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr5:75427937G>A	uc003kei.1	+	2	496	c.362G>A	c.(361-363)CGG>CAG	p.R121Q		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	121	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		AAGGACCGGCGGGAGCTGGAA	0.547000													7	49					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140180884	140180884	+	Silent	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr5:140180884C>A	uc003lhf.2	+	1	102	c.102C>A	c.(100-102)TCC>TCA	p.S34S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S34S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCACTACTCCGTCTCTGAGG	0.667000													26	73					1.85244e-09	2.17353e-09	1	0
PCDHB14	56122	broad.mit.edu	37	5	140605383	140605383	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr5:140605383C>A	uc003ljb.2	+	1	2306	c.2306C>A	c.(2305-2307)CCG>CAG	p.P769Q	PCDHB14_uc011dal.1_Missense_Mutation_p.P616Q	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	769	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCTGAAGCCGATTATCCCC	0.453000													8	90					5.4927e-09	6.35997e-09	1	0
TBC1D9B	23061	broad.mit.edu	37	5	179321452	179321452	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr5:179321452G>A	uc003mlh.2	-	4	548	c.511C>T	c.(511-513)CGG>TGG	p.R171W	TBC1D9B_uc003mli.2_Missense_Mutation_p.R171W|TBC1D9B_uc003mlj.2_Missense_Mutation_p.R171W	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	171	GRAM 1.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCCCTGCCGGGGCACGCGG	0.627000													3	41					0	0	0	0
DAXX	1616	broad.mit.edu	37	6	33288181	33288181	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr6:33288181G>A	uc003oec.2	-	4	1431	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.P334P|DAXX_uc011dre.1_Silent_p.P421P|DAXX_uc003oed.2_Silent_p.P409P|DAXX_uc010juw.2_Silent_p.P334P	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	409	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						AGGAGGCTTCGGGGGTGTCTG	0.542000			Mis|F|N		Pancreatic neuroendocrine tumors								4	85					0	0	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333446	33333446	+	Missense_Mutation	SNP	C	T	T	rs115420448	by1000genomes	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr6:33333446C>T	uc003shx.2	-	1	694	c.560G>A	c.(559-561)CGG>CAG	p.R187Q		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GACAACAGACCGGAGCTTCTC	0.592000													3	18					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4116798	4116798	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr7:4116798C>T	uc003smx.2	+	21	3318	c.3179C>T	c.(3178-3180)ACC>ATC	p.T1060I	SDK1_uc010kso.2_Missense_Mutation_p.T336I	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1060	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACTTCATCCACCATTTCTTCT	0.562000													6	27					0	0	0	0
NUP205	23165	broad.mit.edu	37	7	135323426	135323426	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr7:135323426G>A	uc003vsw.2	+	38	5418	c.5387G>A	c.(5386-5388)CGG>CAG	p.R1796Q	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1796					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GATGGACCGCGGCAAGGTGAG	0.438000													43	108					0	0	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919983	142919983	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr7:142919983T>C	uc011ksx.1	+	1	812	c.812T>C	c.(811-813)TTT>TCT	p.F271S		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	271	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TCCAACATCTTTGACACTTAC	0.473000													33	86					0	0	0	0
ZNF322B	387328	broad.mit.edu	37	9	99961655	99961655	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr9:99961655C>T	uc004axd.1	-	1	256	c.139G>A	c.(139-141)GAA>AAA	p.E47K	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				TGCTTGCATTCAAGGCACTGG	0.338000													11	303					0	0	0	0
ZNF449	203523	broad.mit.edu	37	X	134483215	134483215	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chrX:134483215G>T	uc004eys.2	+	3	700	c.535G>T	c.(535-537)GAA>TAA	p.E179*	ZNF449_uc004eyq.1_3'UTR|ZNF449_uc004eyt.2_Nonsense_Mutation_p.E59*	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	179					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTACTGGAGAATGTCAGAA	0.537000													10	99					7.48243e-07	8.33486e-07	1	0
TREX2	11219	broad.mit.edu	37	X	152710829	152710829	+	Silent	SNP	G	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chrX:152710829G>A	uc010nue.1	-	3	302	c.186C>T	c.(184-186)CTC>CTT	p.L62L	TREX2_uc010nud.1_Silent_p.L20L|TREX2_uc011myp.1_Silent_p.L20L|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	63					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACACTGGGGAGCCCAGTGG	0.622000								Editing_and_processing_nucleases					5	6					0	0	0	0
FAM3A	60343	broad.mit.edu	37	X	153740200	153740200	+	Silent	SNP	T	A	A			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chrX:153740200T>A	uc004fls.1	-	3	409	c.132A>T	c.(130-132)CCA>CCT	p.P44P	FAM3A_uc004flt.1_Silent_p.P58P|FAM3A_uc011mzp.1_Silent_p.P44P|FAM3A_uc004flu.1_Silent_p.P58P|FAM3A_uc011mzq.1_Silent_p.P44P|FAM3A_uc004flw.1_Silent_p.P44P	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	44						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGAGCTCTCTGGACCTGTGG	0.632000											OREG0003614	type=REGULATORY REGION|Gene=FAM3A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	36					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16475205	16475210	+	In_Frame_Del	DEL	TTCAGC	-	-	rs146626026	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:16475205_16475210delTTCAGC	uc001aya.1	-	3	623_628	c.486_491delGCTGAA	c.(484-492)AAGCTGAAC>AAC	p.KL162del	EPHA2_uc010oca.1_In_Frame_Del_p.KL162del	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	162_163	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTCCTCCACGTTCAGCTTCACGTGGC	0.612													---	---	---							
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	Frame_Shift_Ins	INS	-	AGCT	AGCT	rs141324796	by1000genomes	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:17034125_17034126insAGCT	uc001azn.1	-	3	478_479	c.364_365insAGCT	c.(364-366)TGGfs	p.W122fs	ESPNP_uc010ocj.1_Frame_Shift_Ins_p.W52fs	NR_026567				RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; AltName: Full=Autosomal recessive deafness type 36 protein;												0						CAGCAGCAGCCAGCTGAGCACC	0.663													---	---	---							
KHDRBS1	10657	broad.mit.edu	37	1	32498892	32498892	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:32498892delT	uc001bub.2	+	4	834	c.728delT	c.(727-729)CTTfs	p.L243fs	KHDRBS1_uc001bua.1_Frame_Shift_Del_p.L204fs|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	243					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCTTATGCTCTTATGGCCCAT	0.458													---	---	---							
Unknown	0	broad.mit.edu	37	1	189223022	189223023	+	IGR	INS	-	T	T	rs113290842		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:189223022_189223023insT								None (None upstream) : FAM5C (843774 downstream)																							TCCGCTTGCACTTTTTTTTTTT	0.431													---	---	---							
UBQLN3	50613	broad.mit.edu	37	11	5529918	5529920	+	In_Frame_Del	DEL	TGG	-	-	rs2234451	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:5529918_5529920delTGG	uc001may.1	-	2	955_957	c.869_871delCCA	c.(868-873)ACCAGC>AGC	p.T290del	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	290										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGGTTGGCTGGTGGTGGTGGT	0.537													---	---	---							
RIC3	79608	broad.mit.edu	37	11	8158952	8158953	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:8158952_8158953insT	uc001mgd.2	-	4	547_548	c.493_494insA	c.(493-495)ATCfs	p.I165fs	RIC3_uc001mgb.2_5'UTR|RIC3_uc001mgc.2_Frame_Shift_Ins_p.I165fs|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Frame_Shift_Ins_p.I115fs|RIC3_uc010rbm.1_Frame_Shift_Ins_p.I165fs|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	165	Potential.|Cytoplasmic (Potential).			I -> F (in Ref. 6; AAH22455).		endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CACTCTGTTGATTAATTTTTCC	0.342													---	---	---							
SPSB2	84727	broad.mit.edu	37	12	6981568	6981569	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:6981568_6981569delTC	uc001qrl.2	-	2	653_654	c.497_498delGA	c.(496-498)AGAfs	p.R166fs	SPSB2_uc001qrm.2_Frame_Shift_Del_p.R166fs|SPSB2_uc010sfp.1_Frame_Shift_Del_p.R166fs|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	166	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						CCACCAGCAGTCTCTCTGGCAC	0.644											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
Unknown	0	broad.mit.edu	37	12	77115366	77115366	+	IGR	DEL	A	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:77115366delA								OSBPL8 (161777 upstream) : ZDHHC17 (42488 downstream)																							GAATCCCCTCAAAAAAAAGTG	0.358													---	---	---							
YLPM1	56252	broad.mit.edu	37	14	75230471	75230471	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:75230471delG	uc001xqj.3	+	1	403	c.279delG	c.(277-279)CCGfs	p.P93fs		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	93	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CAGTGATGCCGGGGGGCGGCT	0.682													---	---	---							
Unknown	0	broad.mit.edu	37	17	21518930	21518930	+	IGR	DEL	A	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:21518930delA								C17orf51 (41199 upstream) : FAM27L (306440 downstream)																							GAGGAAAAAGAAGAGGGGAGA	0.388													---	---	---							
Unknown	0	broad.mit.edu	37	17	25308941	25308943	+	IGR	DEL	TGA	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:25308941_25308943delTGA								None (None upstream) : WSB1 (312163 downstream)																							CCGTGCTCTTTGAGGAGAAGAAC	0.586													---	---	---							
GGCX	2677	broad.mit.edu	37	2	85779683	85779683	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:85779683delG	uc002sps.2	-	10	1401	c.1295delC	c.(1294-1296)ACAfs	p.T432fs	GGCX_uc010yss.1_Frame_Shift_Del_p.T271fs|GGCX_uc010yst.1_Frame_Shift_Del_p.T375fs	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	432	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CCGACTCTGTGTAAATACCTG	0.512											OREG0014747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
NCL	4691	broad.mit.edu	37	2	232326268	232326285	+	In_Frame_Del	DEL	TCGTCATCCTCATCATCT	-	-	rs80005798	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:232326268_232326285delTCGTCATCCTCATCATCT	uc002vru.2	-	3	720_737	c.579_596delAGATGATGAGGATGACGA	c.(577-597)GAAGATGATGAGGATGACGAT>GAT	p.EDDEDD193del	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	193_198	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ctcatcgtcatcgtcatcctcatcatcttcgtcatcct	0.289													---	---	---							
Unknown	0	broad.mit.edu	37	4	55811699	55811702	+	IGR	DEL	GGAG	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:55811699_55811702delGGAG								KIT (204820 upstream) : KDR (132725 downstream)																							tggcagaggaggagggagggaggg	0.118													---	---	---							
HIST1H2AA	221613	broad.mit.edu	37	6	25727627	25727628	+	5'Flank	INS	-	T	T	rs61603783		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:25727627_25727628insT	uc003nfc.2	-							NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AACCGTAAGGGttttttttttt	0.203													---	---	---							
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:92146721delT	uc003uly.2	-	5	1204	c.1108delA	c.(1108-1110)ATTfs	p.I370fs	PEX1_uc011khr.1_Frame_Shift_Del_p.I162fs|PEX1_uc010ley.2_Frame_Shift_Del_p.I370fs|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													---	---	---							
RIC3	79608	broad.mit.edu	37	11	8158952	8158953	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr11:8158952_8158953insT	uc001mgd.2	-	4	547_548	c.493_494insA	c.(493-495)ATCfs	p.I165fs	RIC3_uc001mgb.2_5'UTR|RIC3_uc001mgc.2_Frame_Shift_Ins_p.I165fs|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Frame_Shift_Ins_p.I115fs|RIC3_uc010rbm.1_Frame_Shift_Ins_p.I165fs|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	165	Potential.|Cytoplasmic (Potential).			I -> F (in Ref. 6; AAH22455).		endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CACTCTGTTGATTAATTTTTCC	0.342													---	---	---							
Unknown	0	broad.mit.edu	37	12	77115366	77115366	+	IGR	DEL	A	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr12:77115366delA								OSBPL8 (161777 upstream) : ZDHHC17 (42488 downstream)																							GAATCCCCTCAAAAAAAAGTG	0.358													---	---	---							
Unknown	0	broad.mit.edu	37	17	16748911	16748913	+	IGR	DEL	GCT	-	-			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr17:16748911_16748913delGCT								LOC162632 (41092 upstream) : TNFRSF13B (83936 downstream)																							CGCCCTCAAAGCTGCTGCTGCCA	0.650													---	---	---							
HIST1H2AA	221613	broad.mit.edu	37	6	25727627	25727628	+	5'Flank	INS	-	T	T	rs61603783		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	831170c2-4ee6-4524-a570-5023a9e3d1f3	g.chr6:25727627_25727628insT	uc003nfc.2	-							NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AACCGTAAGGGttttttttttt	0.203													---	---	---							
