Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
NECAP2	55707	broad.mit.edu	37	1	16775693	16775693	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:16775693C>T	uc001ayo.2	+	5	576	c.486C>T	c.(484-486)ATC>ATT	p.I162I	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Silent_p.I136I|NECAP2_uc001ayq.2_Silent_p.I162I	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	162					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTCAACATCGCAGTGAGTT	0.502													6	12	---	---	---	---	PASS
EPHA8	2046	broad.mit.edu	37	1	22913107	22913107	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:22913107C>T	uc001bfx.1	+	4	1083	c.958C>T	c.(958-960)CCG>TCG	p.P320S	EPHA8_uc001bfw.2_Missense_Mutation_p.P320S	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	320	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGCCCTGGACCCGCCGTCCTC	0.677													17	24	---	---	---	---	PASS
PTPRU	10076	broad.mit.edu	37	1	29609186	29609186	+	Splice_Site	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:29609186A>T	uc001bru.2	+	12	1979	c.1869_splice	c.e12-2	p.S623_splice	PTPRU_uc001brv.2_Splice_Site_p.S623_splice|PTPRU_uc001brw.2_Splice_Site_p.S623_splice|PTPRU_uc009vtq.2_Splice_Site_p.S623_splice|PTPRU_uc009vtr.2_Splice_Site_p.S623_splice	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U						canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTCCCTGTCCAGTGTGTACCA	0.493													8	37	---	---	---	---	PASS
WDR63	126820	broad.mit.edu	37	1	85564330	85564330	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:85564330G>A	uc001dkt.2	+	13	1659	c.1468G>A	c.(1468-1470)GAC>AAC	p.D490N	WDR63_uc009wcl.2_Missense_Mutation_p.D451N	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	490	WD 2.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CTGGTTGTCTGACACATTTGA	0.348													49	61	---	---	---	---	PASS
PALMD	54873	broad.mit.edu	37	1	100154844	100154844	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:100154844C>T	uc001dsg.2	+	7	1471	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L	PALMD_uc001dsf.2_Missense_Mutation_p.P343L	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	343					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTTCACACCCCGCAAAAAAGG	0.488													25	37	---	---	---	---	PASS
RSBN1	54665	broad.mit.edu	37	1	114319901	114319901	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:114319901A>G	uc001edq.2	-	4	1625	c.1589T>C	c.(1588-1590)ATG>ACG	p.M530T	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	530						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTTACCCACATTATAGGCCC	0.443													47	110	---	---	---	---	PASS
IGSF3	3321	broad.mit.edu	37	1	117131648	117131648	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:117131648A>T	uc001egr.1	-	8	2813	c.2108T>A	c.(2107-2109)GTC>GAC	p.V703D	IGSF3_uc001egq.1_Missense_Mutation_p.V723D|IGSF3_uc001egs.1_Missense_Mutation_p.V376D	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	703	Ig-like C2-type 6.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CTGAGACTTGACTGAGCAGTT	0.527													46	101	---	---	---	---	PASS
ANKRD35	148741	broad.mit.edu	37	1	145562900	145562900	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:145562900C>T	uc001eob.1	+	10	2696	c.2588C>T	c.(2587-2589)GCC>GTC	p.A863V	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.A706V	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	863	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TATAATACGGCCTGCCGGGAA	0.677													7	19	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152283513	152283513	+	Silent	SNP	G	A	A	rs150992326	byFrequency	TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:152283513G>A	uc001ezu.1	-	3	3885	c.3849C>T	c.(3847-3849)TCC>TCT	p.S1283S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1283	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACAACCTCTCGGAGTCGTCTG	0.383									Ichthyosis				111	238	---	---	---	---	PASS
INTS3	65123	broad.mit.edu	37	1	153735804	153735804	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:153735804C>T	uc009wom.2	+	17	1953	c.1732C>T	c.(1732-1734)CTG>TTG	p.L578L	INTS3_uc001fct.2_Silent_p.L578L|INTS3_uc001fcu.2_Silent_p.L270L|INTS3_uc001fcv.2_Silent_p.L372L|INTS3_uc010peb.1_Silent_p.L372L|INTS3_uc001fcw.2_Silent_p.L91L|INTS3_uc010pec.1_Silent_p.L91L	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	579					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGATGAGTCCCTGAGGGACAA	0.512													4	176	---	---	---	---	PASS
TDRD10	126668	broad.mit.edu	37	1	154492811	154492811	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:154492811A>G	uc009wow.2	+	5	1011	c.173A>G	c.(172-174)AAC>AGC	p.N58S	TDRD10_uc001ffd.2_Missense_Mutation_p.N58S|TDRD10_uc001ffe.2_5'Flank	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	58	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGGACTTCAACCCTCTTGAT	0.418													28	62	---	---	---	---	PASS
CHRNB2	1141	broad.mit.edu	37	1	154544002	154544002	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:154544002C>T	uc001ffg.2	+	5	967	c.703C>T	c.(703-705)CTC>TTC	p.L235F		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	235	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	CCGCAAGCCGCTCTTCTACAC	0.572													50	134	---	---	---	---	PASS
CRABP2	1382	broad.mit.edu	37	1	156675204	156675204	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:156675204C>T	uc001fpr.2	-	1	172	c.35G>A	c.(34-36)CGA>CAA	p.R12Q		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	12					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	GTTTTCCGATCGGATGATTTT	0.577													34	86	---	---	---	---	PASS
PYHIN1	149628	broad.mit.edu	37	1	158943530	158943530	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:158943530A>T	uc001ftb.2	+	8	1698	c.1453A>T	c.(1453-1455)ACC>TCC	p.T485S	PYHIN1_uc001ftc.2_Missense_Mutation_p.T476S|PYHIN1_uc001ftd.2_Intron|PYHIN1_uc001fte.2_Intron	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	485					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					TGACACTTCCACCAACCGCCA	0.458													35	79	---	---	---	---	PASS
PAPPA2	60676	broad.mit.edu	37	1	176760601	176760601	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:176760601A>T	uc001gkz.2	+	19	6167	c.5003A>T	c.(5002-5004)GAA>GTA	p.E1668V	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1668	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TACAAATGTGAACAAGGATAT	0.388													17	60	---	---	---	---	PASS
ZNF648	127665	broad.mit.edu	37	1	182025847	182025847	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:182025847G>A	uc001goz.2	-	2	1507	c.1299C>T	c.(1297-1299)TCC>TCT	p.S433S		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	433	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGGACAGATTGGAGGACTTGG	0.692													3	4	---	---	---	---	PASS
PRG4	10216	broad.mit.edu	37	1	186278006	186278006	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:186278006C>G	uc001gru.3	+	7	3206	c.3155C>G	c.(3154-3156)CCC>CGC	p.P1052R	PRG4_uc001grt.3_Missense_Mutation_p.P1011R|PRG4_uc009wyl.2_Missense_Mutation_p.P959R|PRG4_uc009wym.2_Missense_Mutation_p.P918R|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1052					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACACCAACTCCCCGCAAGATG	0.458													5	107	---	---	---	---	PASS
CRB1	23418	broad.mit.edu	37	1	197403847	197403847	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:197403847G>T	uc001gtz.2	+	9	2989	c.2854G>T	c.(2854-2856)GCT>TCT	p.A952S	CRB1_uc010poz.1_Missense_Mutation_p.A928S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.A840S|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.A433S|CRB1_uc001gub.1_Missense_Mutation_p.A601S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	952	Extracellular (Potential).|EGF-like 14.|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TATTGCAAATGCTGTTTTTAA	0.308													22	54	---	---	---	---	PASS
IGFN1	91156	broad.mit.edu	37	1	201196154	201196154	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:201196154A>G	uc001gwc.2	+	12	3183	c.2411A>G	c.(2410-2412)CAC>CGC	p.H804R	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCCCGGCCCCACGTCACCTGG	0.677													26	64	---	---	---	---	PASS
USH2A	7399	broad.mit.edu	37	1	216420069	216420069	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:216420069C>G	uc001hku.1	-	13	3054	c.2667G>C	c.(2665-2667)TTG>TTC	p.L889F	USH2A_uc001hkv.2_Missense_Mutation_p.L889F	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	889	Laminin EGF-like 7.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTCAATGGTCAAATTGTACC	0.468										HNSCC(13;0.011)			97	142	---	---	---	---	PASS
SNAP47	116841	broad.mit.edu	37	1	227935399	227935399	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr1:227935399A>G	uc001hrf.2	+	2	511	c.97A>G	c.(97-99)AAG>GAG	p.K33E	SNAP47_uc001hqz.2_5'UTR|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Missense_Mutation_p.K33E|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_5'UTR	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	33						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						TCAGAGGCAGAAGAGGCCTGG	0.607													24	47	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	905474	905474	+	RNA	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:905474G>A	uc010ewg.2	-	1		c.109C>T			uc010ewh.1_Nonsense_Mutation_p.Q158*					Homo sapiens cDNA FLJ46162 fis, clone TESTI4002520.																		CACTGGGTCTGGTGTTTCATT	0.612													72	141	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	905558	905558	+	RNA	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:905558G>A	uc010ewg.2	-	1		c.25C>T			uc010ewh.1_Nonsense_Mutation_p.Q130*					Homo sapiens cDNA FLJ46162 fis, clone TESTI4002520.																		CACTGGGTCTGGTGTTTCATT	0.597													6	209	---	---	---	---	PASS
KCNF1	3754	broad.mit.edu	37	2	11053295	11053295	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:11053295T>A	uc002rax.2	+	1	1233	c.743T>A	c.(742-744)CTG>CAG	p.L248Q		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	248	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CCCAACAAGCTGCACTTCGCG	0.617													24	59	---	---	---	---	PASS
APOB	338	broad.mit.edu	37	2	21252821	21252821	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:21252821C>T	uc002red.2	-	11	1547	c.1419G>A	c.(1417-1419)CAG>CAA	p.Q473Q		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	473	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATCTTGAATCTGTTCCATCA	0.418													25	124	---	---	---	---	PASS
ATAD2B	54454	broad.mit.edu	37	2	24118806	24118806	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:24118806T>A	uc002rek.3	-	2	545	c.251A>T	c.(250-252)CAC>CTC	p.H84L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc010exx.1_Missense_Mutation_p.H84L	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	84							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGATACGTGGCTATCACT	0.343													29	39	---	---	---	---	PASS
ZNF513	130557	broad.mit.edu	37	2	27600640	27600640	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:27600640G>T	uc002rkk.2	-	4	1598	c.1398C>A	c.(1396-1398)CAC>CAA	p.H466Q	ZNF513_uc002rkj.2_Missense_Mutation_p.H404Q	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	466	C2H2-type 7.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCGCCTGTGTGCCGCAGCA	0.587													68	194	---	---	---	---	PASS
PLB1	151056	broad.mit.edu	37	2	28766132	28766132	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:28766132G>T	uc002rmb.1	+	14	933	c.933G>T	c.(931-933)AGG>AGT	p.R311S	PLB1_uc010ezj.1_Missense_Mutation_p.R322S	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	311	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					TCTGGAATAGGATGGTGAGTA	0.627													6	16	---	---	---	---	PASS
BIRC6	57448	broad.mit.edu	37	2	32703790	32703790	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:32703790C>G	uc010ezu.2	+	36	7290	c.7156C>G	c.(7156-7158)CTT>GTT	p.L2386V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2386					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ACTGCTGTTACTTTTGGTTGG	0.433													29	132	---	---	---	---	PASS
RPIA	22934	broad.mit.edu	37	2	88991249	88991249	+	Nonsense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:88991249C>G	uc002ste.2	+	1	74	c.33C>G	c.(31-33)TAC>TAG	p.Y11*		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	11					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				GCACCCTCTACGGGCGGGTCT	0.572													17	33	---	---	---	---	PASS
FAM123C	205147	broad.mit.edu	37	2	131520797	131520797	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:131520797C>T	uc002trw.2	+	2	1342	c.1152C>T	c.(1150-1152)GAC>GAT	p.D384D	FAM123C_uc010fmv.2_Silent_p.D384D|FAM123C_uc010fms.1_Silent_p.D384D|FAM123C_uc010fmt.1_Silent_p.D384D|FAM123C_uc010fmu.1_Silent_p.D384D	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	384										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCACAAGTGACGAGGGCTACT	0.627													33	47	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133531461	133531461	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:133531461C>G	uc002ttp.2	-	16	5430	c.5056G>C	c.(5056-5058)GAG>CAG	p.E1686Q	NCKAP5_uc002ttq.2_Missense_Mutation_p.E367Q	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1686							protein binding				0						TCATTTGCCTCTTTTACCTGC	0.328													11	181	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141274521	141274521	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:141274521A>G	uc002tvj.1	-	50	9058	c.8086T>C	c.(8086-8088)TTG>CTG	p.L2696L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2696	Extracellular (Potential).|LDL-receptor class A 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGGTATTCAAAATGCATCTT	0.333										TSP Lung(27;0.18)			3	48	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141533667	141533667	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:141533667C>A	uc002tvj.1	-	33	6472	c.5500G>T	c.(5500-5502)GGC>TGC	p.G1834C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1834	Extracellular (Potential).|EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTGATTTACCTTGCTGTGCT	0.383										TSP Lung(27;0.18)			22	49	---	---	---	---	PASS
DCAF17	80067	broad.mit.edu	37	2	172305295	172305295	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:172305295G>T	uc002ugx.2	+	4	655	c.426G>T	c.(424-426)GAG>GAT	p.E142D	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Missense_Mutation_p.E142D|DCAF17_uc010zdr.1_RNA	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	142						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						AAATCCTTGAGAAAATATATC	0.318													6	131	---	---	---	---	PASS
EVX2	344191	broad.mit.edu	37	2	176948394	176948394	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:176948394G>T	uc010zeu.1	-	1	297	c.111C>A	c.(109-111)CTC>CTA	p.L37L		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	37						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CCAGGGCCTCGAGCACAGCAT	0.597													43	74	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179593626	179593626	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:179593626A>G	uc010zfg.1	-	62	15631	c.15407T>C	c.(15406-15408)TTA>TCA	p.L5136S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L1797S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6063							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTGTACTAAAAGGAAAGC	0.393													15	36	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179611814	179611814	+	Nonsense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:179611814G>A	uc002unb.2	-	46	15537	c.15313C>T	c.(15313-15315)CGA>TGA	p.R5105*	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGAATATCGCTCTAGAGTC	0.493													37	88	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179635302	179635302	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:179635302C>G	uc010zfg.1	-	35	8441	c.8217G>C	c.(8215-8217)CAG>CAC	p.Q2739H	TTN_uc010zfh.1_Missense_Mutation_p.Q2693H|TTN_uc010zfi.1_Missense_Mutation_p.Q2693H|TTN_uc010zfj.1_Missense_Mutation_p.Q2693H|TTN_uc002unb.2_Missense_Mutation_p.Q2739H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2739							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTGATCCACTGGACACCTT	0.413													39	90	---	---	---	---	PASS
PDE1A	5136	broad.mit.edu	37	2	183066211	183066211	+	Silent	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:183066211C>G	uc002uos.2	-	11	1212	c.1128G>C	c.(1126-1128)CTG>CTC	p.L376L	PDE1A_uc010zfp.1_Silent_p.L272L|PDE1A_uc002uoq.1_Silent_p.L376L|PDE1A_uc010zfq.1_Silent_p.L376L|PDE1A_uc002uor.2_Silent_p.L360L|PDE1A_uc002uou.2_Silent_p.L342L	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	376	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACCGATAATGCAGCTTCCAGG	0.473													48	85	---	---	---	---	PASS
GLS	2744	broad.mit.edu	37	2	191792155	191792155	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:191792155A>T	uc002usf.2	+	12	1636	c.1372A>T	c.(1372-1374)AGT>TGT	p.S458C	GLS_uc002use.2_Missense_Mutation_p.S458C|GLS_uc002usg.1_Missense_Mutation_p.S119C|GLS_uc002ush.2_Missense_Mutation_p.S119C|GLS_uc010zgi.1_Missense_Mutation_p.S29C|GLS_uc010zgj.1_5'Flank	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	458					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAATACATTGAGTTTGATGCA	0.428													28	72	---	---	---	---	PASS
SMARCAL1	50485	broad.mit.edu	37	2	217293404	217293404	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:217293404G>C	uc002vgc.3	+	7	1563	c.1233G>C	c.(1231-1233)AAG>AAC	p.K411N	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.K411N|SMARCAL1_uc010fvg.2_Missense_Mutation_p.K411N	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	411					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		AGCTCAAGAAGACATCTCTCA	0.537									Schimke_Immuno-Osseous_Dysplasia				41	107	---	---	---	---	PASS
SP100	6672	broad.mit.edu	37	2	231326018	231326018	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:231326018T>C	uc002vqt.2	+	9	1003	c.862T>C	c.(862-864)TCC>CCC	p.S288P	SP100_uc002vqs.2_Missense_Mutation_p.S288P|SP100_uc002vqu.1_Missense_Mutation_p.S288P|SP100_uc010zmb.1_Missense_Mutation_p.S288P|SP100_uc002vqq.1_Missense_Mutation_p.S288P|SP100_uc002vqr.1_Missense_Mutation_p.S263P|SP100_uc010zmc.1_Missense_Mutation_p.S263P|SP100_uc002vqv.1_Missense_Mutation_p.S252P	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	288	PxVxL motif.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CCAAATTAATTCCTGTTCTGT	0.403													10	47	---	---	---	---	PASS
DGKD	8527	broad.mit.edu	37	2	234372821	234372821	+	Silent	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr2:234372821G>C	uc002vui.1	+	27	3210	c.3198G>C	c.(3196-3198)CCG>CCC	p.P1066P	DGKD_uc002vuj.1_Silent_p.P1022P|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	1066					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	AGCTGGATCCGCCTCAGAAGG	0.677													14	45	---	---	---	---	PASS
FBLN2	2199	broad.mit.edu	37	3	13671366	13671366	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:13671366G>A	uc011avb.1	+	13	2873	c.2748G>A	c.(2746-2748)ACG>ACA	p.T916T	FBLN2_uc011auz.1_Silent_p.T942T|FBLN2_uc011ava.1_Silent_p.T963T|FBLN2_uc011avc.1_Silent_p.T963T	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	916	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCCAGCACACGTGTGAGAACA	0.647													6	6	---	---	---	---	PASS
FBXW12	285231	broad.mit.edu	37	3	48423471	48423471	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:48423471C>A	uc003csr.2	+	10	1377	c.1191C>A	c.(1189-1191)TCC>TCA	p.S397S	FBXW12_uc010hjv.2_Silent_p.S378S|FBXW12_uc003css.2_Silent_p.S327S|FBXW12_uc010hjw.2_Silent_p.S296S	NM_207102	NP_996985	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12 isoform	397	WD 5.										0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCACCACATCCGAGAACTCTG	0.507													4	96	---	---	---	---	PASS
COL7A1	1294	broad.mit.edu	37	3	48612666	48612666	+	Nonsense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:48612666C>A	uc003ctz.2	-	74	6191	c.6190G>T	c.(6190-6192)GGA>TGA	p.G2064*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2064	Triple-helical region.		G -> R (in DDEB).		cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCTTTCTCTCCCCGTTCTCCC	0.632													37	54	---	---	---	---	PASS
P4HTM	54681	broad.mit.edu	37	3	49044195	49044195	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:49044195A>G	uc003cvg.2	+	9	1713	c.1364A>G	c.(1363-1365)AAC>AGC	p.N455S	P4HTM_uc003cvh.2_Missense_Mutation_p.N516S|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	455	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	TGGATTGCCAACAACTGGATT	0.632													23	32	---	---	---	---	PASS
GNAT1	2779	broad.mit.edu	37	3	50231296	50231296	+	Missense_Mutation	SNP	T	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:50231296T>G	uc003cym.2	+	5	676	c.560T>G	c.(559-561)TTC>TGC	p.F187C	GNAT1_uc003cyl.2_Missense_Mutation_p.F187C	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	187					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CAGTTCTCCTTCAAGGATCTC	0.652													28	39	---	---	---	---	PASS
KIAA2018	205717	broad.mit.edu	37	3	113377404	113377404	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:113377404C>G	uc003eam.2	-	7	3536	c.3125G>C	c.(3124-3126)AGT>ACT	p.S1042T	KIAA2018_uc003eal.2_Missense_Mutation_p.S986T	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1042					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TAAATTCACACTTGAATCAAC	0.358													3	104	---	---	---	---	PASS
ADPRH	141	broad.mit.edu	37	3	119301046	119301046	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:119301046G>T	uc003ecs.2	+	3	328	c.30G>T	c.(28-30)CTG>CTT	p.L10L	ADPRH_uc010hqv.2_Silent_p.L10L|ADPRH_uc011bjb.1_Intron|ADPRH_uc003ect.2_Silent_p.L10L	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	10					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CTATGGTGCTGAGTGCAGCTG	0.547													17	59	---	---	---	---	PASS
ADPRH	141	broad.mit.edu	37	3	119301047	119301047	+	Missense_Mutation	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:119301047A>C	uc003ecs.2	+	3	329	c.31A>C	c.(31-33)AGT>CGT	p.S11R	ADPRH_uc010hqv.2_Missense_Mutation_p.S11R|ADPRH_uc011bjb.1_Intron|ADPRH_uc003ect.2_Missense_Mutation_p.S11R	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	11					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		TATGGTGCTGAGTGCAGCTGG	0.542													16	57	---	---	---	---	PASS
UROC1	131669	broad.mit.edu	37	3	126224833	126224833	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:126224833A>G	uc003eiz.1	-	7	656	c.624T>C	c.(622-624)GGT>GGC	p.G208G	UROC1_uc010hsi.1_Silent_p.G208G	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	208					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		AGCAGTAGCTACCTGCTGTCA	0.637													3	64	---	---	---	---	PASS
PLSCR2	57047	broad.mit.edu	37	3	146173087	146173087	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:146173087A>T	uc003evv.1	-	5	593	c.260T>A	c.(259-261)GTC>GAC	p.V87D	PLSCR2_uc003evw.1_Missense_Mutation_p.V156D	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	87	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						CAGAGTTATGACTTCTCGACC	0.408													45	116	---	---	---	---	PASS
GPR149	344758	broad.mit.edu	37	3	154146767	154146767	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:154146767G>C	uc003faa.2	-	1	738	c.638C>G	c.(637-639)ACT>AGT	p.T213S		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	213	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CAATCGGTGAGTGAGTGGGAC	0.592													61	122	---	---	---	---	PASS
C3orf33	285315	broad.mit.edu	37	3	155493633	155493633	+	Nonsense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:155493633G>C	uc003fal.1	-	4	320	c.50C>G	c.(49-51)TCA>TGA	p.S17*	C3orf33_uc003fam.1_Nonsense_Mutation_p.S60*	NM_173657	NP_775928	Q96NB5	Q96NB5_HUMAN	hypothetical protein LOC285315	17							hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGTAAATTTTGATGTCTATTG	0.284													7	198	---	---	---	---	PASS
GFM1	85476	broad.mit.edu	37	3	158371155	158371155	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:158371155C>A	uc003fce.2	+	7	1004	c.897C>A	c.(895-897)AGC>AGA	p.S299R	GFM1_uc003fcd.2_Missense_Mutation_p.S299R|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.S230R	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	299					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTTTGGGAAGCGCCTTGAAGA	0.353													38	73	---	---	---	---	PASS
RTP1	132112	broad.mit.edu	37	3	186915549	186915549	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:186915549G>C	uc003frg.2	+	1	276	c.246G>C	c.(244-246)CAG>CAC	p.Q82H		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	82	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GTTGGAAGCAGTACCTGGAAT	0.572													20	234	---	---	---	---	PASS
MFI2	4241	broad.mit.edu	37	3	196754711	196754711	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr3:196754711G>T	uc003fxk.3	-	2	233	c.120C>A	c.(118-120)AGC>AGA	p.S40R	MFI2_uc003fxl.3_Missense_Mutation_p.S40R|MFI2_uc011bua.1_Missense_Mutation_p.S40R	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	40	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GGAAGGCCTCGCTCATGTTGC	0.701													3	35	---	---	---	---	PASS
NKX3-2	579	broad.mit.edu	37	4	13544131	13544131	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:13544131T>C	uc003gmx.2	-	2	564	c.488A>G	c.(487-489)GAG>GGG	p.E163G		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	163					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ACCGTCGTCCTCGGTCCTTGG	0.483													3	32	---	---	---	---	PASS
PACRGL	133015	broad.mit.edu	37	4	20715163	20715163	+	Splice_Site	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:20715163G>T	uc010iek.2	+	7	1000	c.609_splice	c.e7+1	p.S203_splice	PACRGL_uc003gpu.2_Splice_Site|PACRGL_uc003gpz.2_Splice_Site_p.S203_splice|PACRGL_uc011bxm.1_Splice_Site_p.S150_splice|PACRGL_uc003gqa.2_Splice_Site_p.S105_splice|PACRGL_uc003gpx.3_Splice_Site|PACRGL_uc003gpv.2_Splice_Site_p.S203_splice|PACRGL_uc003gpw.2_Splice_Site|PACRGL_uc010iej.1_Splice_Site|PACRGL_uc011bxn.1_Splice_Site_p.S105_splice|PACRGL_uc003gpy.2_Splice_Site_p.S150_splice	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1								binding				0						GCTTACAAGCGTAAGTACTGC	0.368													18	44	---	---	---	---	PASS
TECRL	253017	broad.mit.edu	37	4	65175582	65175582	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:65175582C>G	uc003hcv.2	-	6	728	c.619G>C	c.(619-621)GTT>CTT	p.V207L	TECRL_uc003hcw.2_Missense_Mutation_p.V207L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	207					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CCTGCAGAAACTTTGTGAACA	0.318													57	127	---	---	---	---	PASS
SHROOM3	57619	broad.mit.edu	37	4	77676030	77676030	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:77676030G>T	uc011cbx.1	+	7	5347	c.4394G>T	c.(4393-4395)AGT>ATT	p.S1465I	SHROOM3_uc003hkg.2_Missense_Mutation_p.S1243I	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1465					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AGTCTTCCAAGTTTATGCAGC	0.562													6	110	---	---	---	---	PASS
GPRIN3	285513	broad.mit.edu	37	4	90169836	90169836	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:90169836A>G	uc003hsm.1	-	2	1945	c.1426T>C	c.(1426-1428)TGC>CGC	p.C476R		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	476										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GCTTGACTGCATGCACTGATA	0.453													8	115	---	---	---	---	PASS
HSPA4L	22824	broad.mit.edu	37	4	128725243	128725243	+	Splice_Site	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:128725243G>T	uc003ifm.2	+	8	1238	c.985_splice	c.e8+1	p.N329_splice	HSPA4L_uc010iny.1_Splice_Site_p.N288_splice|HSPA4L_uc011cgr.1_Splice_Site_p.N296_splice	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like						protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GAACAAGCTAGTAAGTGGAAA	0.328													18	72	---	---	---	---	PASS
KIAA0922	23240	broad.mit.edu	37	4	154523864	154523864	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:154523864C>T	uc003inm.3	+	23	2673	c.2621C>T	c.(2620-2622)ACG>ATG	p.T874M	KIAA0922_uc010ipp.2_Missense_Mutation_p.T875M|KIAA0922_uc010ipq.2_Missense_Mutation_p.T643M	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	874	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TGGAGGCTCACGGTCTTCTTT	0.512													13	207	---	---	---	---	PASS
DCHS2	54798	broad.mit.edu	37	4	155155906	155155906	+	Missense_Mutation	SNP	T	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:155155906T>G	uc003inw.2	-	25	8533	c.8533A>C	c.(8533-8535)AAC>CAC	p.N2845H		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2845					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGCCCCAGGTTTACTGCCGGC	0.502													69	131	---	---	---	---	PASS
TKTL2	84076	broad.mit.edu	37	4	164393737	164393737	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:164393737C>A	uc003iqp.3	-	1	1311	c.1150G>T	c.(1150-1152)GGT>TGT	p.G384C		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	384						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATGGTTCGACCACGTGTAGCA	0.433													19	67	---	---	---	---	PASS
TKTL2	84076	broad.mit.edu	37	4	164394531	164394531	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr4:164394531A>G	uc003iqp.3	-	1	517	c.356T>C	c.(355-357)GTT>GCT	p.V119A		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	119						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGCCACGTCAACAAACGGCAA	0.542													18	47	---	---	---	---	PASS
GHR	2690	broad.mit.edu	37	5	42695031	42695031	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:42695031A>G	uc003jmt.2	+	5	322	c.279A>G	c.(277-279)GAA>GAG	p.E93E	GHR_uc011cpq.1_5'UTR	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	93	Extracellular (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ACactcaagaatggactcaag	0.303													10	23	---	---	---	---	PASS
PARP8	79668	broad.mit.edu	37	5	50137846	50137846	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:50137846G>A	uc003jon.3	+	27	2691	c.2509G>A	c.(2509-2511)GGA>AGA	p.G837R	PARP8_uc011cpz.1_Missense_Mutation_p.G729R|PARP8_uc003joo.2_Missense_Mutation_p.G837R|PARP8_uc003jop.2_Missense_Mutation_p.G795R	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	837	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TACACAAGAAGGAGGCATTCA	0.358													19	79	---	---	---	---	PASS
PARP8	79668	broad.mit.edu	37	5	50137849	50137849	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:50137849G>C	uc003jon.3	+	27	2694	c.2512G>C	c.(2512-2514)GGC>CGC	p.G838R	PARP8_uc011cpz.1_Missense_Mutation_p.G730R|PARP8_uc003joo.2_Missense_Mutation_p.G838R|PARP8_uc003jop.2_Missense_Mutation_p.G796R	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	838	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ACAAGAAGGAGGCATTCACAA	0.363													19	74	---	---	---	---	PASS
TMEM161B	153396	broad.mit.edu	37	5	87493533	87493533	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:87493533G>A	uc003kjc.2	-	11	1264	c.1139C>T	c.(1138-1140)GCG>GTG	p.A380V	TMEM161B_uc011cty.1_Missense_Mutation_p.A369V|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_Missense_Mutation_p.A171V	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	380	Helical; (Potential).					integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		TACCAGAGGCGCCACATACTG	0.418													9	115	---	---	---	---	PASS
PAM	5066	broad.mit.edu	37	5	102295636	102295636	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:102295636G>T	uc003knw.2	+	12	1336	c.963G>T	c.(961-963)AAG>AAT	p.K321N	PAM_uc003kns.2_Missense_Mutation_p.K321N|PAM_uc003knt.2_Missense_Mutation_p.K321N|PAM_uc003knu.2_Missense_Mutation_p.K321N|PAM_uc003knv.2_Missense_Mutation_p.K321N|PAM_uc011cuz.1_Missense_Mutation_p.K224N|PAM_uc003knx.1_Missense_Mutation_p.K13N	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	321	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TGGAAGCCAAGCATGCAGTTT	0.393													22	24	---	---	---	---	PASS
PRR16	51334	broad.mit.edu	37	5	119800226	119800226	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:119800226C>A	uc003ksq.2	+	1	208	c.45C>A	c.(43-45)GCC>GCA	p.A15A	PRR16_uc003ksp.2_5'UTR	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	15										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CCTGTCCAGCCGAGGGACCGC	0.612													4	8	---	---	---	---	PASS
DPYSL3	1809	broad.mit.edu	37	5	146777324	146777324	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:146777324C>T	uc003lon.1	-	12	1476	c.1366G>A	c.(1366-1368)GAT>AAT	p.D456N	DPYSL3_uc003loo.2_Missense_Mutation_p.D570N	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	456					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTTGCCATCTTCCAGCATG	0.577													58	24	---	---	---	---	PASS
ADAM19	8728	broad.mit.edu	37	5	156936311	156936311	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:156936311G>T	uc003lwz.2	-	9	967	c.903C>A	c.(901-903)ATC>ATA	p.I301I	ADAM19_uc003lww.1_Silent_p.I34I|ADAM19_uc011ddr.1_Silent_p.I232I	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	301	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTATTTACGTGATTAATTGGG	0.493													21	18	---	---	---	---	PASS
CDHR2	54825	broad.mit.edu	37	5	176011425	176011425	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr5:176011425G>A	uc003mem.1	+	19	2209	c.2143G>A	c.(2143-2145)GTG>ATG	p.V715M	CDHR2_uc003men.1_Missense_Mutation_p.V715M	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	715	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCTAGTGGGCGTGGTGAAGGC	0.612													66	60	---	---	---	---	PASS
SERPINB6	5269	broad.mit.edu	37	6	2954829	2954829	+	Nonsense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:2954829C>A	uc003muk.2	-	3	2422	c.427G>T	c.(427-429)GAA>TAA	p.E143*	SERPINB6_uc003mui.2_Nonsense_Mutation_p.E26*|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Nonsense_Mutation_p.E143*|SERPINB6_uc003mum.2_Nonsense_Mutation_p.E143*|SERPINB6_uc003mun.2_Nonsense_Mutation_p.E143*|SERPINB6_uc003muo.2_Nonsense_Mutation_p.E143*	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	143					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	TTTTCACCTTCTGTCTTTTCA	0.373													7	72	---	---	---	---	PASS
HIST1H3E	8353	broad.mit.edu	37	6	26225532	26225532	+	Silent	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:26225532C>G	uc003nhb.2	+	2	510	c.150C>G	c.(148-150)CGC>CGG	p.R50R	HIST1H3E_uc003nhc.3_Silent_p.R50R	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	50					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				TGGCTCTGCGCGAGATCCGTC	0.632													6	82	---	---	---	---	PASS
HSP90AB1	3326	broad.mit.edu	37	6	44216403	44216403	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:44216403G>C	uc003oxa.1	+	2	121	c.37G>C	c.(37-39)GAG>CAG	p.E13Q	HSP90AB1_uc011dvr.1_Missense_Mutation_p.E13Q|HSP90AB1_uc003oxb.1_Missense_Mutation_p.E13Q|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	13					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGAGGAGGTGGAGACTTTTGC	0.408													7	149	---	---	---	---	PASS
OPN5	221391	broad.mit.edu	37	6	47763175	47763175	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:47763175C>A	uc003ozc.2	+	4	637	c.632C>A	c.(631-633)CCA>CAA	p.P211Q	OPN5_uc003ozd.2_Missense_Mutation_p.P46Q	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	211	Helical; Name=5; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						CTCTTGCTCCCAACGGCTGTG	0.542													42	108	---	---	---	---	PASS
RIMS1	22999	broad.mit.edu	37	6	72967967	72967967	+	Silent	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:72967967A>T	uc003pga.2	+	17	2987	c.2910A>T	c.(2908-2910)CCA>CCT	p.P970P	RIMS1_uc011dyb.1_Silent_p.P595P|RIMS1_uc003pgc.2_Silent_p.P596P|RIMS1_uc010kaq.2_Silent_p.P443P|RIMS1_uc011dyc.1_Silent_p.P444P|RIMS1_uc010kar.2_Silent_p.P363P|RIMS1_uc011dyd.1_Silent_p.P429P|RIMS1_uc003pgf.2_Silent_p.P186P|RIMS1_uc003pgg.2_Silent_p.P187P|RIMS1_uc003pgi.2_Silent_p.P186P|RIMS1_uc003pgh.2_Silent_p.P186P|RIMS1_uc003pgd.2_Silent_p.P187P|RIMS1_uc003pge.2_Silent_p.P187P|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Silent_p.P596P|RIMS1_uc010kas.1_Silent_p.P429P	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	970					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CACGTTTACCAAATGTGCCAT	0.433													17	47	---	---	---	---	PASS
LAMA2	3908	broad.mit.edu	37	6	129609117	129609117	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:129609117T>C	uc003qbn.2	+	19	2768	c.2663T>C	c.(2662-2664)ATA>ACA	p.I888T	LAMA2_uc003qbo.2_Missense_Mutation_p.I888T	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	888	Laminin EGF-like 8.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCCTGTCTGATATGTAAACCA	0.502													84	209	---	---	---	---	PASS
LAMA2	3908	broad.mit.edu	37	6	129833550	129833550	+	Missense_Mutation	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:129833550A>C	uc003qbn.2	+	62	9005	c.8900A>C	c.(8899-8901)GAA>GCA	p.E2967A	LAMA2_uc003qbo.2_Missense_Mutation_p.E2963A|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2967	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTAGAATTTGAATTCCGCACA	0.368													5	91	---	---	---	---	PASS
SASH1	23328	broad.mit.edu	37	6	148855979	148855979	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:148855979G>A	uc003qme.1	+	16	2512	c.2037G>A	c.(2035-2037)AGG>AGA	p.R679R	SASH1_uc011eeb.1_Silent_p.R440R|SASH1_uc003qmf.1_Silent_p.R89R	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	679	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TAAATATCAGGGACCCGGAAC	0.483													7	75	---	---	---	---	PASS
OPRM1	4988	broad.mit.edu	37	6	154360850	154360850	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:154360850C>G	uc003qpr.2	+	1	408	c.171C>G	c.(169-171)AGC>AGG	p.S57R	OPRM1_uc011efb.1_Missense_Mutation_p.S105R|OPRM1_uc011efc.1_Intron|OPRM1_uc011efd.1_Intron|OPRM1_uc011efe.1_Missense_Mutation_p.S150R|OPRM1_uc003qpn.2_Missense_Mutation_p.S57R|OPRM1_uc003qpo.1_Missense_Mutation_p.S57R|OPRM1_uc011eff.1_Missense_Mutation_p.S57R|OPRM1_uc011efg.1_Missense_Mutation_p.S57R|OPRM1_uc011efh.1_Missense_Mutation_p.S57R|OPRM1_uc003qpq.1_Missense_Mutation_p.S57R|OPRM1_uc003qpt.1_Missense_Mutation_p.S57R|OPRM1_uc011efi.1_Missense_Mutation_p.S57R|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	57	Extracellular (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GGAGAGACAGCCTGTGCCCTC	0.637													31	30	---	---	---	---	PASS
SLC22A1	6580	broad.mit.edu	37	6	160553345	160553345	+	Nonsense_Mutation	SNP	C	G	G	rs151091788	byFrequency	TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:160553345C>G	uc003qtc.2	+	3	702	c.597C>G	c.(595-597)TAC>TAG	p.Y199*	SLC22A1_uc003qtd.2_Nonsense_Mutation_p.Y199*	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	199	Extracellular (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		CGCCCAACTACATGTCCATGC	0.577													5	118	---	---	---	---	PASS
PACRG	135138	broad.mit.edu	37	6	163483206	163483206	+	Missense_Mutation	SNP	C	T	T	rs143858923		TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:163483206C>T	uc003qua.2	+	4	540	c.316C>T	c.(316-318)CAT>TAT	p.H106Y	PACRG_uc003qub.2_Missense_Mutation_p.H106Y|PACRG_uc003quc.2_Missense_Mutation_p.H106Y	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	106											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		GCTGGATTACCATCATTATCT	0.453													26	64	---	---	---	---	PASS
WDR27	253769	broad.mit.edu	37	6	170068228	170068228	+	Missense_Mutation	SNP	T	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr6:170068228T>G	uc003qwx.2	-	5	1030	c.510A>C	c.(508-510)AAA>AAC	p.K170N	WDR27_uc010kkw.1_Missense_Mutation_p.K170N|WDR27_uc003qwy.2_Intron|WDR27_uc011egw.1_Intron			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GTGGTGGGACTTTGTGGCGGT	0.507													32	43	---	---	---	---	PASS
SDK1	221935	broad.mit.edu	37	7	3991545	3991545	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:3991545C>G	uc003smx.2	+	7	1282	c.1143C>G	c.(1141-1143)TTC>TTG	p.F381L		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	381					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCTTTCTTTTCATCATAGGTA	0.577													27	42	---	---	---	---	PASS
ZNF479	90827	broad.mit.edu	37	7	57200012	57200012	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:57200012G>T	uc010kzo.2	-	2	291	c.20C>A	c.(19-21)CCC>CAC	p.P7H		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GCTTCCAGGGGGTCCTGGTCT	0.557													21	59	---	---	---	---	PASS
PEX1	5189	broad.mit.edu	37	7	92146842	92146842	+	Silent	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:92146842A>C	uc003uly.2	-	5	1083	c.987T>G	c.(985-987)ACT>ACG	p.T329T	PEX1_uc011khr.1_Silent_p.T121T|PEX1_uc010ley.2_Silent_p.T329T|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	329					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CATATGTCACAGTAAAGCTGG	0.378													10	59	---	---	---	---	PASS
GAL3ST4	79690	broad.mit.edu	37	7	99757893	99757893	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:99757893G>A	uc003utt.2	-	3	2136	c.1119C>T	c.(1117-1119)TTC>TTT	p.F373F	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Silent_p.F373F|GAL3ST4_uc010lgq.2_Silent_p.F311F	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	373	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GACTGCGGTTGAAGTGGACAT	0.627													5	131	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100696357	100696357	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:100696357G>T	uc003uxp.1	+	10	13247	c.13194G>T	c.(13192-13194)GGG>GGT	p.G4398G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4398	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGGGGGCAGGGGTCGTGCTGA	0.597													10	55	---	---	---	---	PASS
ORC5L	5001	broad.mit.edu	37	7	103824482	103824482	+	Splice_Site	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:103824482C>A	uc003vcb.2	-	8	845	c.734_splice	c.e8-1	p.A245_splice	ORC5L_uc011klp.1_Splice_Site_p.A113_splice|ORC5L_uc003vcc.2_Splice_Site_p.A245_splice	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1						cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						CGTTCACTTGCTACCCCAAAG	0.318													5	108	---	---	---	---	PASS
SSPO	23145	broad.mit.edu	37	7	149515170	149515170	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:149515170C>T	uc010lpk.2	+	81	11560	c.11560C>T	c.(11560-11562)CCC>TCC	p.P3854S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3854	TSP type-1 16.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGCCGTGGGCCCCGCCAGGA	0.642													9	12	---	---	---	---	PASS
ATG9B	285973	broad.mit.edu	37	7	150720201	150720201	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:150720201C>G	uc011kvc.1	-	4	828	c.752G>C	c.(751-753)AGA>ACA	p.R251T	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	251	Lumenal (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGCCCAGGTCTGGTATGGTT	0.527													46	287	---	---	---	---	PASS
CNPY1	285888	broad.mit.edu	37	7	155301727	155301727	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr7:155301727G>A	uc003wmc.1	-	2	151	c.6C>T	c.(4-6)AAC>AAT	p.N2N		NM_001103176	NP_001096646	Q3B7I2	CNPY1_HUMAN	canopy 1 homolog	2											0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GCTTGTAGTCGTTCATTCGCT	0.438													50	66	---	---	---	---	PASS
SGK223	157285	broad.mit.edu	37	8	8234654	8234654	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:8234654G>A	uc003wsh.3	-	2	1265	c.1265C>T	c.(1264-1266)CCG>CTG	p.P422L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	422							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGAAGGCACCGGAGCTGCCTT	0.627													3	61	---	---	---	---	PASS
PXDNL	137902	broad.mit.edu	37	8	52321350	52321350	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:52321350G>A	uc003xqu.3	-	17	2935	c.2834C>T	c.(2833-2835)GCG>GTG	p.A945V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	945					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTCCTGTCGCGCGCACTCGGT	0.652													5	22	---	---	---	---	PASS
NSMAF	8439	broad.mit.edu	37	8	59502566	59502566	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:59502566A>G	uc003xtt.2	-	25	2301	c.2087T>C	c.(2086-2088)GTC>GCC	p.V696A	NSMAF_uc011lee.1_Missense_Mutation_p.V727A	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	696	WD 2.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				AGATACATACACATTATTATC	0.428													15	31	---	---	---	---	PASS
PREX2	80243	broad.mit.edu	37	8	69069635	69069635	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:69069635C>T	uc003xxv.1	+	35	4337	c.4310C>T	c.(4309-4311)TCA>TTA	p.S1437L		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1437					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AATGCAGCCTCACTGGAAAAG	0.343													11	38	---	---	---	---	PASS
EYA1	2138	broad.mit.edu	37	8	72184094	72184094	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:72184094C>G	uc003xys.3	-	9	1152	c.865G>C	c.(865-867)GAT>CAT	p.D289H	EYA1_uc003xyr.3_Missense_Mutation_p.D284H|EYA1_uc003xyt.3_Missense_Mutation_p.D256H|EYA1_uc010lzf.2_Missense_Mutation_p.D216H|EYA1_uc003xyu.2_Missense_Mutation_p.D289H|EYA1_uc011lfe.1_Missense_Mutation_p.D283H|EYA1_uc003xyv.2_Missense_Mutation_p.D167H	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	289					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GAATCTGAATCTTTAATGGGT	0.458													14	331	---	---	---	---	PASS
TRPA1	8989	broad.mit.edu	37	8	72938268	72938268	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:72938268C>G	uc003xza.2	-	25	3153	c.2978G>C	c.(2977-2979)TGG>TCG	p.W993S	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	993	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GCGTAGAAACCAAAGTGGCAG	0.363													51	103	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77764838	77764838	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:77764838C>A	uc003yav.2	+	10	5933	c.5546C>A	c.(5545-5547)TCC>TAC	p.S1849Y	ZFHX4_uc003yau.1_Missense_Mutation_p.S1894Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.S1849Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1849						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGGAACCATCCATCCCACCA	0.418										HNSCC(33;0.089)			18	11	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77765435	77765435	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:77765435C>A	uc003yav.2	+	10	6530	c.6143C>A	c.(6142-6144)CCC>CAC	p.P2048H	ZFHX4_uc003yau.1_Missense_Mutation_p.P2093H|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2048H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2048	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCGCTTCCTCCCCAGCTTGCC	0.507										HNSCC(33;0.089)			4	1	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77765936	77765936	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:77765936C>A	uc003yav.2	+	10	7031	c.6644C>A	c.(6643-6645)TCC>TAC	p.S2215Y	ZFHX4_uc003yau.1_Missense_Mutation_p.S2260Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.S2215Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2215	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAACAACTCTCCACTGTTCTC	0.408										HNSCC(33;0.089)			11	13	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77765937	77765937	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:77765937C>A	uc003yav.2	+	10	7032	c.6645C>A	c.(6643-6645)TCC>TCA	p.S2215S	ZFHX4_uc003yau.1_Silent_p.S2260S|ZFHX4_uc003yaw.1_Silent_p.S2215S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2215	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACAACTCTCCACTGTTCTCA	0.408										HNSCC(33;0.089)			11	13	---	---	---	---	PASS
PKHD1L1	93035	broad.mit.edu	37	8	110437406	110437406	+	Silent	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:110437406A>T	uc003yne.2	+	24	2894	c.2790A>T	c.(2788-2790)GCA>GCT	p.A930A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	930	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCAAGCTGCATCTCCACCTC	0.348										HNSCC(38;0.096)			3	39	---	---	---	---	PASS
SCRIB	23513	broad.mit.edu	37	8	144891120	144891120	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:144891120G>A	uc003yzp.1	-	15	1781	c.1774C>T	c.(1774-1776)CCC>TCC	p.P592S	SCRIB_uc003yzo.1_Missense_Mutation_p.P592S	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	592	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGGGTCCAGGGGGCCTCAGGC	0.647													59	85	---	---	---	---	PASS
EXOSC4	54512	broad.mit.edu	37	8	145135352	145135352	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:145135352A>G	uc003zau.2	+	3	696	c.586A>G	c.(586-588)ATT>GTT	p.I196V	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	196					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCAGGACAGATTGCGCTGCT	0.667													27	123	---	---	---	---	PASS
AGTPBP1	23287	broad.mit.edu	37	9	88292479	88292479	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:88292479C>T	uc011ltd.1	-	5	341	c.308G>A	c.(307-309)AGT>AAT	p.S103N	AGTPBP1_uc011ltc.1_Missense_Mutation_p.S45N|AGTPBP1_uc010mqc.2_Missense_Mutation_p.S103N|AGTPBP1_uc011lte.1_Missense_Mutation_p.S155N	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	103					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GACTAAGAAACTCACTCTTCG	0.279													31	68	---	---	---	---	PASS
FAM120A	23196	broad.mit.edu	37	9	96326821	96326821	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:96326821A>G	uc004atw.2	+	18	3381	c.3356A>G	c.(3355-3357)TAA>TGA	p.*1119*	FAM120A_uc004aty.2_Silent_p.*900*|FAM120A_uc004atz.2_Silent_p.*767*|FAM120A_uc010mrg.2_Silent_p.*386*|FAM120A_uc004aua.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	1119						cytoplasm|plasma membrane	RNA binding				0						AAAGAAGAGTAAACTTATTTT	0.408													41	60	---	---	---	---	PASS
FANCC	2176	broad.mit.edu	37	9	97912344	97912344	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:97912344G>C	uc004avh.2	-	7	809	c.547C>G	c.(547-549)CTG>GTG	p.L183V	FANCC_uc004avi.3_Missense_Mutation_p.L183V|FANCC_uc010mrm.1_RNA|FANCC_uc011lul.1_RNA	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	183					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				ACTCGTGACAGGGACGCCACT	0.463			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				17	65	---	---	---	---	PASS
ZNF782	158431	broad.mit.edu	37	9	99581208	99581208	+	Missense_Mutation	SNP	T	C	C	rs145150698	byFrequency	TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:99581208T>C	uc004awp.1	-	6	1378	c.1097A>G	c.(1096-1098)TAT>TGT	p.Y366C	ZNF782_uc011lup.1_Missense_Mutation_p.Y234C	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	366	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				ATTATACTCATAGGGTTTTGC	0.418													11	214	---	---	---	---	PASS
GRIN3A	116443	broad.mit.edu	37	9	104433328	104433328	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:104433328T>C	uc004bbp.1	-	3	1967	c.1366A>G	c.(1366-1368)ATC>GTC	p.I456V	GRIN3A_uc004bbq.1_Missense_Mutation_p.I456V	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	456	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GAGCTGACGATGGTGGAACCT	0.483													65	170	---	---	---	---	PASS
SUSD1	64420	broad.mit.edu	37	9	114886687	114886687	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:114886687G>A	uc004bfu.2	-	6	777	c.736C>T	c.(736-738)CGG>TGG	p.R246W	SUSD1_uc010mui.2_Missense_Mutation_p.R246W|SUSD1_uc010muj.2_Missense_Mutation_p.R246W	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	246	Sushi 2.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						ATGGCGTGCCGCATTTCTGGA	0.507													45	71	---	---	---	---	PASS
PHF19	26147	broad.mit.edu	37	9	123632136	123632136	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:123632136G>A	uc004bks.1	-	5	705	c.452C>T	c.(451-453)GCA>GTA	p.A151V	PHF19_uc011lyf.1_5'Flank|PHF19_uc004bkr.2_5'Flank|PHF19_uc004bkt.2_Missense_Mutation_p.A151V|PHF19_uc010mvk.2_3'UTR	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	151	PHD-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						CACAGCCAGTGCGAAGATGCA	0.632													4	31	---	---	---	---	PASS
KCNT1	57582	broad.mit.edu	37	9	138683697	138683697	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr9:138683697C>A	uc011mdq.1	+	30	3631	c.3557C>A	c.(3556-3558)CCC>CAC	p.P1186H	KCNT1_uc011mdr.1_Missense_Mutation_p.P1034H|KCNT1_uc010nbf.2_Missense_Mutation_p.P1162H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	1186						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AACCCTCCGCCCGACACGAGG	0.642													19	68	---	---	---	---	PASS
FBXO18	84893	broad.mit.edu	37	10	5948139	5948139	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:5948139C>T	uc001iis.2	+	3	392	c.297C>T	c.(295-297)AGC>AGT	p.S99S	FBXO18_uc001iir.2_Silent_p.S25S|FBXO18_uc009xig.2_Silent_p.S25S|FBXO18_uc001iit.2_Silent_p.S150S	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	99					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CTGCAGAGAGCAGCTGTGCAC	0.597													9	64	---	---	---	---	PASS
C10orf140	387640	broad.mit.edu	37	10	21805147	21805147	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:21805147C>T	uc009xkd.2	-	4	3858	c.1605G>A	c.(1603-1605)CCG>CCA	p.P535P	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	454						nucleus	nucleotide binding			ovary(1)	1						CCAGGCTGGCCGGGCAGTACA	0.547													21	48	---	---	---	---	PASS
PTCHD3	374308	broad.mit.edu	37	10	27702399	27702399	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:27702399G>T	uc001itu.2	-	1	899	c.781C>A	c.(781-783)CTC>ATC	p.L261I		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	261					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GGCACGCAGAGCGCCCTGTAC	0.632													17	24	---	---	---	---	PASS
KIAA1462	57608	broad.mit.edu	37	10	30315900	30315900	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:30315900C>T	uc001iux.2	-	2	3236	c.3177G>A	c.(3175-3177)CAG>CAA	p.Q1059Q	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.Q921Q|KIAA1462_uc009xle.1_Silent_p.Q1059Q	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1059										ovary(4)	4						CACTGGCACCCTGTTCTTGCC	0.597													12	205	---	---	---	---	PASS
ANKRD30A	91074	broad.mit.edu	37	10	37508513	37508513	+	Silent	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:37508513A>C	uc001iza.1	+	34	3804	c.3705A>C	c.(3703-3705)ACA>ACC	p.T1235T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1291	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AACGTGAAACACAGTGTCAAA	0.363													5	30	---	---	---	---	PASS
LZTS2	84445	broad.mit.edu	37	10	102766372	102766372	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:102766372G>C	uc001ksj.2	+	5	1526	c.1457G>C	c.(1456-1458)CGG>CCG	p.R486P	LZTS2_uc010qpw.1_Missense_Mutation_p.R486P|LZTS2_uc001ksk.2_Missense_Mutation_p.R486P|LZTS2_uc001ksl.2_Missense_Mutation_p.R486P|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	486	Potential.|Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing (By similarity).|Sufficient for interaction with CTNNB1.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GCTACGCTGCGGGTCAGTGAG	0.687													5	5	---	---	---	---	PASS
PNLIPRP2	5408	broad.mit.edu	37	10	118396302	118396302	+	Missense_Mutation	SNP	T	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:118396302T>G	uc001lcq.2	+	12	969	c.946T>G	c.(946-948)TGT>GGT	p.C316G	PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	315					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		CTAGAGTAAGTGTTTCCCTTG	0.383													3	10	---	---	---	---	PASS
INPP5A	3632	broad.mit.edu	37	10	134579331	134579331	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr10:134579331G>C	uc001llp.2	+	12	1206	c.958G>C	c.(958-960)GAC>CAC	p.D320H	INPP5A_uc001llo.1_Missense_Mutation_p.D320H|INPP5A_uc001llq.2_Missense_Mutation_p.D215H	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	320					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		GTATGAACTGGACATCTCGTT	0.493													4	89	---	---	---	---	PASS
PHRF1	57661	broad.mit.edu	37	11	608509	608509	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:608509G>T	uc001lqe.2	+	14	3184	c.3053G>T	c.(3052-3054)CGC>CTC	p.R1018L	PHRF1_uc010qwc.1_Missense_Mutation_p.R1017L|PHRF1_uc010qwd.1_Missense_Mutation_p.R1016L|PHRF1_uc010qwe.1_Missense_Mutation_p.R1014L|PHRF1_uc009ybz.1_Missense_Mutation_p.R808L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1018	Arg-rich.						RNA polymerase binding|zinc ion binding				0						GGACGGACGCGCTCTGGGACG	0.672													14	43	---	---	---	---	PASS
KCNQ1	3784	broad.mit.edu	37	11	2608873	2608873	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:2608873G>T	uc001lwn.2	+	9	1310	c.1202G>T	c.(1201-1203)CGG>CTG	p.R401L	KCNQ1_uc009ydp.1_Missense_Mutation_p.R185L|KCNQ1_uc001lwo.2_Missense_Mutation_p.R274L	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	401	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	AAGGCCCCCCGGAGCCACACT	0.642													31	76	---	---	---	---	PASS
OR51B5	282763	broad.mit.edu	37	11	5364468	5364468	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:5364468A>G	uc001map.1	-	1	287	c.287T>C	c.(286-288)TTT>TCT	p.F96S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Missense_Mutation_p.F96S	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCTGGGAAAAGCAGGCCGC	0.552													4	53	---	---	---	---	PASS
OR51I1	390063	broad.mit.edu	37	11	5462308	5462308	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:5462308A>G	uc010qze.1	-	1	437	c.437T>C	c.(436-438)ATG>ACG	p.M146T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCCAGACCCATAGCCAATAT	0.483													35	54	---	---	---	---	PASS
OR56B1	387748	broad.mit.edu	37	11	5758258	5758258	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:5758258T>A	uc001mbt.1	+	1	512	c.512T>A	c.(511-513)CTT>CAT	p.L171H	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Missense_Mutation_p.L171H|OR56B1_uc009yev.1_Missense_Mutation_p.L171H	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GTGCCTGTGCTTGCAGCACAG	0.473													42	84	---	---	---	---	PASS
OR52N4	390072	broad.mit.edu	37	11	5776678	5776678	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:5776678G>A	uc001mbu.2	+	1	756	c.708G>A	c.(706-708)CGG>CGA	p.R236R	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CAGATGCTCGGCAGAAGGCCT	0.502													66	113	---	---	---	---	PASS
NLRP14	338323	broad.mit.edu	37	11	7079556	7079556	+	Silent	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:7079556T>C	uc001mfb.1	+	8	2831	c.2508T>C	c.(2506-2508)TCT>TCC	p.S836S		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	836	LRR 4.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGTATCTTTCTTTGGCTCTCA	0.453													49	84	---	---	---	---	PASS
SBF2	81846	broad.mit.edu	37	11	9861056	9861056	+	Silent	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:9861056T>C	uc001mib.2	-	26	3582	c.3444A>G	c.(3442-3444)TCA>TCG	p.S1148S	SBF2_uc001mif.3_Silent_p.S904S|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1148	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCCGGCAGAGTGAATACATCC	0.443													67	130	---	---	---	---	PASS
PIK3C2A	5286	broad.mit.edu	37	11	17113137	17113137	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:17113137C>A	uc001mmq.3	-	30	4775	c.4709G>T	c.(4708-4710)CGA>CTA	p.R1570L	PIK3C2A_uc009ygu.1_Missense_Mutation_p.R173L|PIK3C2A_uc010rcw.1_Missense_Mutation_p.R1190L|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1570	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	AGTACCATTTCGGTAAGAGAT	0.383													3	74	---	---	---	---	PASS
PIK3C2A	5286	broad.mit.edu	37	11	17153551	17153551	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:17153551G>C	uc001mmq.3	-	11	2209	c.2143C>G	c.(2143-2145)CAC>GAC	p.H715D	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.H335D|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	715					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTTCCATTGTGAGACAGTGAA	0.274													22	142	---	---	---	---	PASS
LRRC4C	57689	broad.mit.edu	37	11	40136309	40136309	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:40136309T>C	uc001mxa.1	-	2	3498	c.1534A>G	c.(1534-1536)ATA>GTA	p.I512V	LRRC4C_uc001mxc.1_Missense_Mutation_p.I508V|LRRC4C_uc001mxd.1_Missense_Mutation_p.I508V|LRRC4C_uc001mxb.1_Missense_Mutation_p.I508V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	512					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CCACTGTTTATATCAGTCACT	0.498													29	67	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55432843	55432843	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:55432843G>A	uc001nht.3	+	3	466	c.201G>A	c.(199-201)TTG>TTA	p.L67L	OR4C6_uc010rik.1_Silent_p.L67L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGTCCCTTTTGGATGTCATGT	0.448													25	115	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55433068	55433068	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:55433068G>A	uc001nht.3	+	3	691	c.426G>A	c.(424-426)ATG>ATA	p.M142I	OR4C6_uc010rik.1_Missense_Mutation_p.M142I	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTGCCTAATGGTAGGAGGGG	0.493													43	75	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55433069	55433069	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:55433069G>T	uc001nht.3	+	3	692	c.427G>T	c.(427-429)GTA>TTA	p.V143L	OR4C6_uc010rik.1_Missense_Mutation_p.V143L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTGCCTAATGGTAGGAGGGGC	0.488													42	75	---	---	---	---	PASS
OR10W1	81341	broad.mit.edu	37	11	58034971	58034971	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:58034971C>T	uc001nmq.1	-	1	762	c.360G>A	c.(358-360)CCG>CCA	p.P120P		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GGTACTGCAACGGGTGGCAAA	0.532													9	41	---	---	---	---	PASS
TIGD3	220359	broad.mit.edu	37	11	65123817	65123817	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:65123817T>A	uc001odo.3	+	2	701	c.538T>A	c.(538-540)TTG>ATG	p.L180M		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	180	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TGAATTGCCCTTGCTGTATCG	0.602													34	180	---	---	---	---	PASS
CNIH2	254263	broad.mit.edu	37	11	66050605	66050605	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:66050605T>C	uc001ohi.1	+	4	530	c.298T>C	c.(298-300)TAC>CAC	p.Y100H	CNIH2_uc001ohh.2_Missense_Mutation_p.Y100H|CNIH2_uc009yrb.1_RNA	NM_182553	NP_872359	Q6PI25	CNIH2_HUMAN	cornichon homolog 2	100	Cytoplasmic (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|dendritic spine|endoplasmic reticulum membrane|postsynaptic density|postsynaptic membrane	protein binding				0						CCTCCTCTTCTACCACCTCTG	0.612											OREG0021100	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	97	---	---	---	---	PASS
NUDT8	254552	broad.mit.edu	37	11	67396482	67396482	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:67396482C>G	uc001omo.1	-	2	254	c.235G>C	c.(235-237)GTG>CTG	p.V79L	NUDT8_uc001omn.2_Missense_Mutation_p.V79L	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	79	Nudix box.|Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding				0						GCCGTGTGCACCACATCTTGG	0.642											OREG0021134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	100	---	---	---	---	PASS
CLPB	81570	broad.mit.edu	37	11	72091393	72091393	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:72091393G>C	uc001osj.2	-	4	628	c.578C>G	c.(577-579)CCA>CGA	p.P193R	CLPB_uc010rqx.1_Missense_Mutation_p.P148R|CLPB_uc010rqy.1_Missense_Mutation_p.P164R|CLPB_uc001osk.2_Missense_Mutation_p.P193R|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.P22R	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	193	ANK 2.				cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TCCAAGGTTTGGATCAGCCCC	0.488													5	57	---	---	---	---	PASS
MYO7A	4647	broad.mit.edu	37	11	76893063	76893063	+	Nonsense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:76893063G>T	uc001oyb.2	+	24	3243	c.2971G>T	c.(2971-2973)GAG>TAG	p.E991*	MYO7A_uc010rsl.1_Nonsense_Mutation_p.E991*|MYO7A_uc010rsm.1_Nonsense_Mutation_p.E980*|MYO7A_uc001oyc.2_Nonsense_Mutation_p.E991*|MYO7A_uc001oyd.2_Nonsense_Mutation_p.E331*|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Nonsense_Mutation_p.E202*	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	991					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCTGCCTGACGAGGATGAGGA	0.567													19	116	---	---	---	---	PASS
DLG2	1740	broad.mit.edu	37	11	83497769	83497769	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:83497769G>C	uc001paj.2	-	13	1777	c.1474C>G	c.(1474-1476)CAG>GAG	p.Q492E	DLG2_uc001pai.2_Missense_Mutation_p.Q389E|DLG2_uc010rsy.1_Missense_Mutation_p.Q459E|DLG2_uc010rsz.1_Missense_Mutation_p.Q492E|DLG2_uc010rta.1_Missense_Mutation_p.Q492E|DLG2_uc001pak.2_Missense_Mutation_p.Q597E|DLG2_uc010rtb.1_Missense_Mutation_p.Q459E|DLG2_uc001pal.1_Missense_Mutation_p.Q492E|DLG2_uc001pam.1_Missense_Mutation_p.Q531E	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	492	PDZ 3.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GTCACTGTCTGTCCAGCCCCC	0.468													10	87	---	---	---	---	PASS
FAT3	120114	broad.mit.edu	37	11	92616485	92616485	+	Missense_Mutation	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:92616485A>C	uc001pdj.3	+	23	12880	c.12863A>C	c.(12862-12864)AAC>ACC	p.N4288T	FAT3_uc001pdi.3_Missense_Mutation_p.N728T	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4288	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGCCCCCAACCTCCCCGCC	0.657										TCGA Ovarian(4;0.039)			6	44	---	---	---	---	PASS
NPAT	4863	broad.mit.edu	37	11	108042941	108042941	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:108042941G>A	uc001pjz.3	-	13	2872	c.2770C>T	c.(2770-2772)CCA>TCA	p.P924S	NPAT_uc010rvv.1_5'Flank|NPAT_uc001pka.2_Missense_Mutation_p.P719S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	924					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GAAAAGTTTGGTGACACAGCT	0.393													14	151	---	---	---	---	PASS
VWF	7450	broad.mit.edu	37	12	6172175	6172175	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:6172175C>G	uc001qnn.1	-	13	1728	c.1478G>C	c.(1477-1479)AGC>ACC	p.S493T	VWF_uc010set.1_Missense_Mutation_p.S493T	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	493	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTCCCCGTAGCTGAGGCGCAC	0.667											OREG0021618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	67	---	---	---	---	PASS
ACRBP	84519	broad.mit.edu	37	12	6756072	6756072	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:6756072C>T	uc001qpu.1	-	2	198	c.150G>A	c.(148-150)CTG>CTA	p.L50L	ACRBP_uc010sfg.1_Silent_p.L50L	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	50						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						AGGTTGGAGTCAGCAGTGCGA	0.607													55	88	---	---	---	---	PASS
CD163	9332	broad.mit.edu	37	12	7639173	7639173	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:7639173G>T	uc001qsz.3	-	10	2508	c.2380C>A	c.(2380-2382)CGC>AGC	p.R794S	CD163_uc001qta.3_Missense_Mutation_p.R794S|CD163_uc009zfw.2_Missense_Mutation_p.R827S	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	794	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGCCAAATGCGGGATTCTTTT	0.507													11	360	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13716959	13716959	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:13716959C>T	uc001rbt.2	-	13	3392	c.3213G>A	c.(3211-3213)GGG>GGA	p.G1071G		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1071	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTCGATGTTCCCATAGGTGA	0.567													28	52	---	---	---	---	PASS
ARHGDIB	397	broad.mit.edu	37	12	15095561	15095561	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:15095561C>A	uc001rcq.1	-	6	605	c.501G>T	c.(499-501)CTG>CTT	p.L167L	ARHGDIB_uc001rcp.1_RNA	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	167					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						TGCCTCGCGCCAGCATGCCCT	0.532													50	188	---	---	---	---	PASS
ARHGDIB	397	broad.mit.edu	37	12	15095562	15095562	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:15095562A>G	uc001rcq.1	-	6	604	c.500T>C	c.(499-501)CTG>CCG	p.L167P	ARHGDIB_uc001rcp.1_RNA	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	167					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						GCCTCGCGCCAGCATGCCCTT	0.527													50	187	---	---	---	---	PASS
METTL7B	196410	broad.mit.edu	37	12	56075807	56075807	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:56075807C>A	uc010spr.1	+	1	478	c.269C>A	c.(268-270)CCG>CAG	p.P90Q		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	90							methyltransferase activity				0						TTCTACCCACCGGGCTGCAGG	0.567													17	50	---	---	---	---	PASS
ITGA7	3679	broad.mit.edu	37	12	56094858	56094858	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:56094858C>T	uc001shh.2	-	4	715	c.495G>A	c.(493-495)GTG>GTA	p.V165V	ITGA7_uc001shg.2_Silent_p.V165V|ITGA7_uc010sps.1_Silent_p.V68V|ITGA7_uc009znx.2_Silent_p.V52V	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	165	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CCTGGCTGAGCACAAAGCAGC	0.592													24	66	---	---	---	---	PASS
CCDC38	120935	broad.mit.edu	37	12	96300166	96300166	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:96300166T>C	uc001tek.1	-	5	602	c.368A>G	c.(367-369)GAG>GGG	p.E123G		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	123										skin(1)	1						TTTTACTACCTCGAGCAGAAA	0.363													11	48	---	---	---	---	PASS
IGF1	3479	broad.mit.edu	37	12	102813396	102813396	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:102813396C>T	uc001tjp.3	-	3	512	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	IGF1_uc001tjn.2_Missense_Mutation_p.R82Q|IGF1_uc001tjm.2_Missense_Mutation_p.R98Q|IGF1_uc001tjo.2_Missense_Mutation_p.R98Q	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	98	A.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						ATCACAGCTCCGGAAGCAGCA	0.597													3	53	---	---	---	---	PASS
TMEM132D	121256	broad.mit.edu	37	12	129559245	129559245	+	Silent	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr12:129559245T>C	uc009zyl.1	-	9	2803	c.2475A>G	c.(2473-2475)AGA>AGG	p.R825R	TMEM132D_uc001uia.2_Silent_p.R363R	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	825	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTTTGGGCCTTCTGTCACTGA	0.512													4	95	---	---	---	---	PASS
UGGT2	55757	broad.mit.edu	37	13	96513097	96513097	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr13:96513097C>A	uc001vmt.2	-	32	3855	c.3685G>T	c.(3685-3687)GAT>TAT	p.D1229Y		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1229	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTTAGGACATCTTTTTCCTTT	0.259													19	22	---	---	---	---	PASS
TM9SF2	9375	broad.mit.edu	37	13	100181844	100181844	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr13:100181844C>T	uc001voj.1	+	4	590	c.457C>T	c.(457-459)CAC>TAC	p.H153Y	TM9SF2_uc010afz.1_Intron	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	153	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TTATCAACATCACTGGTAAGG	0.294													23	72	---	---	---	---	PASS
NALCN	259232	broad.mit.edu	37	13	101763490	101763490	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr13:101763490G>A	uc001vox.1	-	19	2469	c.2280C>T	c.(2278-2280)ATC>ATT	p.I760I		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	760	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCTCTTGGCGGATATGATGCT	0.522													12	217	---	---	---	---	PASS
TMCO3	55002	broad.mit.edu	37	13	114203835	114203835	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr13:114203835G>A	uc001vtu.3	+	13	2377	c.2016G>A	c.(2014-2016)GAG>GAA	p.E672E		NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	672						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CCAGACCGGAGAGACGGTCCA	0.607													8	34	---	---	---	---	PASS
OR4N5	390437	broad.mit.edu	37	14	20612092	20612092	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr14:20612092G>T	uc010tla.1	+	1	198	c.198G>T	c.(196-198)TTG>TTT	p.L66F		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCAACTTGGCCTTACTGG	0.468													14	209	---	---	---	---	PASS
PARP2	10038	broad.mit.edu	37	14	20824553	20824553	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr14:20824553G>C	uc001vxc.2	+	12	1256	c.1228G>C	c.(1228-1230)GAT>CAT	p.D410H	PARP2_uc001vxd.2_Missense_Mutation_p.D397H|PARP2_uc001vxb.1_Missense_Mutation_p.D410H|PARP2_uc010tle.1_Missense_Mutation_p.D160H	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	410	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		AGTGGAGAAGGATGGTGAGAA	0.458								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					18	166	---	---	---	---	PASS
TPPP2	122664	broad.mit.edu	37	14	21500193	21500193	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr14:21500193G>C	uc001vzh.2	+	4	658	c.470G>C	c.(469-471)AGT>ACT	p.S157T	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	157						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGCTATGTGAGTGGTTACAAG	0.542													9	63	---	---	---	---	PASS
LRFN5	145581	broad.mit.edu	37	14	42361139	42361139	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr14:42361139C>A	uc001wvm.2	+	4	3270	c.2072C>A	c.(2071-2073)ACG>AAG	p.T691K	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	691	Cytoplasmic (Potential).					integral to membrane		p.T691M(1)		ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GAGGGGCCCACGTCTAAAAGA	0.468										HNSCC(30;0.082)			20	28	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	106235847	106235847	+	RNA	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr14:106235847C>G	uc010tyt.1	-	3617		c.58000G>C			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysh.1_RNA|uc001ysi.1_RNA					Parts of antibodies, mostly variable regions.												0						TCTTGGTCATCTCCTCCCGGG	0.637													61	207	---	---	---	---	PASS
C15orf55	256646	broad.mit.edu	37	15	34649392	34649392	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:34649392G>C	uc001zif.2	+	7	3254	c.3099G>C	c.(3097-3099)AGG>AGC	p.R1033S	C15orf55_uc010ucc.1_Missense_Mutation_p.R1061S|C15orf55_uc010ucd.1_Missense_Mutation_p.R1051S	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	1033						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TCTCACCAAGGGAGCATCCCC	0.532			T	BRD3|BRD4	lethal midline carcinoma								25	51	---	---	---	---	PASS
TUBGCP4	27229	broad.mit.edu	37	15	43692396	43692396	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:43692396G>C	uc001zro.2	+	14	1816	c.1576G>C	c.(1576-1578)GAT>CAT	p.D526H	TUBGCP4_uc001zrn.2_Missense_Mutation_p.D525H|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	526					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		ATTTTTGGTGGATAATCTTCA	0.488													29	112	---	---	---	---	PASS
DUOX1	53905	broad.mit.edu	37	15	45426062	45426062	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:45426062G>T	uc001zus.1	+	4	405	c.59G>T	c.(58-60)GGA>GTA	p.G20V	DUOX1_uc001zut.1_Missense_Mutation_p.G20V|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	20					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TCTCACACAGGAGCTCAGAAC	0.577													35	93	---	---	---	---	PASS
SLC24A5	283652	broad.mit.edu	37	15	48413351	48413351	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:48413351C>A	uc001zwe.2	+	1	183	c.110C>A	c.(109-111)CCA>CAA	p.P37Q	SLC24A5_uc001zwd.2_Missense_Mutation_p.P37Q|SLC24A5_uc010bel.2_Missense_Mutation_p.P37Q	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	37	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CAACGTCTCCCAAGGGCCACA	0.572													15	38	---	---	---	---	PASS
FBN1	2200	broad.mit.edu	37	15	48717600	48717600	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:48717600G>T	uc001zwx.1	-	60	7747	c.7419C>A	c.(7417-7419)GGC>GGA	p.G2473G	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2473	EGF-like 42; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCAGAATGTAGCCTTTCGGGC	0.473													6	115	---	---	---	---	PASS
UNC13C	440279	broad.mit.edu	37	15	54630593	54630593	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:54630593T>C	uc002ack.2	+	15	4619	c.4619T>C	c.(4618-4620)ATG>ACG	p.M1540T	UNC13C_uc002acl.2_Missense_Mutation_p.M370T	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1540					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AAAGCGAGCATGGTGGTGAAG	0.433													67	177	---	---	---	---	PASS
TLN2	83660	broad.mit.edu	37	15	63084986	63084986	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:63084986G>T	uc002alb.3	+	43	5883	c.5883G>T	c.(5881-5883)AAG>AAT	p.K1961N	TLN2_uc002alc.3_Missense_Mutation_p.K354N	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1961					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCACGGAAAAGGTAAGGAGCA	0.552													5	32	---	---	---	---	PASS
PLEKHO2	80301	broad.mit.edu	37	15	65158077	65158077	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:65158077G>T	uc002anv.2	+	6	1597	c.1463G>T	c.(1462-1464)AGT>ATT	p.S488I	PLEKHO2_uc010bgz.2_Missense_Mutation_p.S164I|PLEKHO2_uc002anw.2_Missense_Mutation_p.S438I	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	488										ovary(1)|lung(1)	2						TACAGGAGAAGTGCACCCTAG	0.577													15	49	---	---	---	---	PASS
MAN2C1	4123	broad.mit.edu	37	15	75656349	75656349	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:75656349T>C	uc002baf.2	-	6	798	c.781A>G	c.(781-783)ATT>GTT	p.I261V	MAN2C1_uc002bag.2_Missense_Mutation_p.I261V|MAN2C1_uc002bah.2_Missense_Mutation_p.I261V|MAN2C1_uc010bkk.2_Intron|MAN2C1_uc010umi.1_Missense_Mutation_p.I43V|MAN2C1_uc010umj.1_Intron|MAN2C1_uc010umk.1_RNA	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	261					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CCTGTATCAATGTGGCAGTGC	0.418													19	54	---	---	---	---	PASS
HMG20A	10363	broad.mit.edu	37	15	77771649	77771649	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:77771649G>T	uc002bcr.2	+	10	1237	c.1036G>T	c.(1036-1038)GAT>TAT	p.D346Y	HMG20A_uc002bcs.2_Missense_Mutation_p.D346Y	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	346					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.D346N(1)		upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GAACAGACTCGATCGTTAGGG	0.358													22	27	---	---	---	---	PASS
AP3B2	8120	broad.mit.edu	37	15	83331597	83331597	+	Nonsense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:83331597G>T	uc010uoh.1	-	22	2802	c.2625C>A	c.(2623-2625)TAC>TAA	p.Y875*	AP3B2_uc010uoi.1_Nonsense_Mutation_p.Y894*|AP3B2_uc010uoj.1_Nonsense_Mutation_p.Y843*|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Nonsense_Mutation_p.Y511*	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	875					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGCTGAAGGTGTAGTCCACAG	0.617													4	38	---	---	---	---	PASS
AKAP13	11214	broad.mit.edu	37	15	86124590	86124590	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:86124590A>G	uc002blv.1	+	7	3461	c.3291A>G	c.(3289-3291)CTA>CTG	p.L1097L	AKAP13_uc002blt.1_Silent_p.L1097L|AKAP13_uc002blu.1_Silent_p.L1097L|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1097					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TTAATGCTCTACAAGGTATGG	0.473													16	110	---	---	---	---	PASS
ISG20	3669	broad.mit.edu	37	15	89198686	89198686	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:89198686C>T	uc002bmv.1	+	4	763	c.470C>T	c.(469-471)GCA>GTA	p.A157V	ISG20_uc002bmu.1_RNA|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	157					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			GATGCGAGGGCAACGATGGAG	0.602													18	100	---	---	---	---	PASS
PRC1	9055	broad.mit.edu	37	15	91524812	91524812	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr15:91524812C>G	uc002bqm.2	-	5	746	c.589G>C	c.(589-591)GAA>CAA	p.E197Q	PRC1_uc002bqn.2_Missense_Mutation_p.E197Q|PRC1_uc002bqo.2_Missense_Mutation_p.E197Q|PRC1_uc010uqs.1_Missense_Mutation_p.E156Q|PRC1_uc010uqt.1_Missense_Mutation_p.E145Q	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	197	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					ACATCTCTTTCAAAGCTTGTG	0.413													13	66	---	---	---	---	PASS
FLYWCH1	84256	broad.mit.edu	37	16	2987296	2987296	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr16:2987296G>T	uc002csd.2	+	7	2051	c.1688G>T	c.(1687-1689)CGC>CTC	p.R563L	FLYWCH1_uc002csb.2_Missense_Mutation_p.R562L|FLYWCH1_uc002csc.2_Missense_Mutation_p.R562L|FLYWCH1_uc010bsv.2_Missense_Mutation_p.R287L|FLYWCH1_uc002cse.2_Missense_Mutation_p.R18L	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	563	FLYWCH-type 4.					nucleus	DNA binding|metal ion binding				0						ATGGTCATGCGCAGGCACTGC	0.726													11	13	---	---	---	---	PASS
RRN3	54700	broad.mit.edu	37	16	15188060	15188060	+	Missense_Mutation	SNP	G	A	A	rs139679899	by1000genomes	TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr16:15188060G>A	uc002dde.2	-	1	99	c.31C>T	c.(31-33)CCG>TCG	p.P11S	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzq.1_Missense_Mutation_p.P11S|RRN3_uc002ddf.1_Missense_Mutation_p.P11S|uc010bve.1_5'Flank	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	11					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						GCATCTCCCGGCAAACGCGTG	0.637													3	28	---	---	---	---	PASS
RRN3	54700	broad.mit.edu	37	16	15188066	15188066	+	Missense_Mutation	SNP	G	A	A	rs142601938	by1000genomes	TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr16:15188066G>A	uc002dde.2	-	1	93	c.25C>T	c.(25-27)CGT>TGT	p.R9C	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzq.1_Missense_Mutation_p.R9C|RRN3_uc002ddf.1_Missense_Mutation_p.R9C|uc010bve.1_5'Flank	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	9					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						CCCGGCAAACGCGTGTGAAGC	0.642													3	28	---	---	---	---	PASS
ABCC11	85320	broad.mit.edu	37	16	48256530	48256530	+	Silent	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr16:48256530T>A	uc002eff.1	-	5	1106	c.756A>T	c.(754-756)GTA>GTT	p.V252V	ABCC11_uc002efg.1_Silent_p.V252V|ABCC11_uc002efh.1_Silent_p.V252V|ABCC11_uc010vgl.1_Silent_p.V252V	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	252	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGATGTGTATTACAGACTTAA	0.512									Cerumen_Type				23	62	---	---	---	---	PASS
PKD1L2	114780	broad.mit.edu	37	16	81209275	81209275	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr16:81209275G>C	uc002fgh.1	-	15	2518	c.2518C>G	c.(2518-2520)CTG>GTG	p.L840V	PKD1L2_uc002fgg.1_RNA|PKD1L2_uc002fgi.2_Missense_Mutation_p.L155V|PKD1L2_uc002fgj.2_Missense_Mutation_p.L840V|PKD1L2_uc002fgk.1_5'UTR|PKD1L2_uc002fgl.1_Missense_Mutation_p.L96V	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	840	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACTACTGTCAGCACAAAGTCA	0.522													17	100	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:7578235T>C	uc002gim.2	-	6	808	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	TP53_uc002gig.1_Missense_Mutation_p.Y205C|TP53_uc002gih.2_Missense_Mutation_p.Y205C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73C|TP53_uc010cng.1_Missense_Mutation_p.Y73C|TP53_uc002gii.1_Missense_Mutation_p.Y73C|TP53_uc010cnh.1_Missense_Mutation_p.Y205C|TP53_uc010cni.1_Missense_Mutation_p.Y205C|TP53_uc002gij.2_Missense_Mutation_p.Y205C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112C|TP53_uc002gio.2_Missense_Mutation_p.Y73C|TP53_uc010vug.1_Missense_Mutation_p.Y166C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	22	---	---	---	---	PASS
MYH3	4621	broad.mit.edu	37	17	10543520	10543520	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:10543520G>A	uc002gmq.1	-	21	2552	c.2475C>T	c.(2473-2475)GTC>GTT	p.V825V		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	825			V -> D (in DA2A).		muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GCCAGTGCTTGACGTTCATGA	0.468													43	96	---	---	---	---	PASS
TRIM16L	147166	broad.mit.edu	37	17	18638695	18638695	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:18638695G>C	uc002gug.1	+	10	1656	c.969G>C	c.(967-969)AAG>AAC	p.K323N	TRIM16L_uc010vyf.1_Missense_Mutation_p.K377N|TRIM16L_uc002guh.1_Missense_Mutation_p.K323N|TRIM16L_uc010cqg.1_Missense_Mutation_p.K425N|TRIM16L_uc002gui.1_Missense_Mutation_p.K323N|TRIM16L_uc010vyg.1_Missense_Mutation_p.K323N|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	323	B30.2/SPRY.					cytoplasm					0						TTTCCAAGAAGGAAAACGCCA	0.512													30	45	---	---	---	---	PASS
SLFN13	146857	broad.mit.edu	37	17	33767706	33767706	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:33767706T>A	uc002hjk.1	-	4	2932	c.2602A>T	c.(2602-2604)ATC>TTC	p.I868F	SLFN13_uc010wch.1_Missense_Mutation_p.I868F|SLFN13_uc002hjl.2_Missense_Mutation_p.I868F|SLFN13_uc010ctt.2_Missense_Mutation_p.I550F|SLFN13_uc002hjm.2_Missense_Mutation_p.I537F	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	868						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTTGGATGGATCCCAAACACT	0.483													57	104	---	---	---	---	PASS
ACACA	31	broad.mit.edu	37	17	35487070	35487070	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:35487070G>T	uc002hnm.2	-	46	5834	c.5643C>A	c.(5641-5643)ACC>ACA	p.T1881T	ACACA_uc002hnk.2_Silent_p.T1803T|ACACA_uc002hnl.2_Silent_p.T1823T|ACACA_uc002hnn.2_Silent_p.T1881T|ACACA_uc002hno.2_Silent_p.T1918T|ACACA_uc010cuy.2_Silent_p.T526T|ACACA_uc010wdc.1_Silent_p.T7T	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1881	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CAGTGCAGTGGGTCACCCCAT	0.532													54	83	---	---	---	---	PASS
OR4D2	124538	broad.mit.edu	37	17	56247203	56247203	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:56247203C>T	uc010wnp.1	+	1	187	c.187C>T	c.(187-189)CTC>TTC	p.L63F		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GTACTTTCTGCTCCGAAACCT	0.473													100	130	---	---	---	---	PASS
MRC2	9902	broad.mit.edu	37	17	60753804	60753804	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:60753804G>T	uc002jad.2	+	11	2148	c.1746G>T	c.(1744-1746)ACG>ACT	p.T582T	MRC2_uc002jac.2_Silent_p.T582T|MRC2_uc010ddq.1_RNA	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	582	Extracellular (Potential).|C-type lectin 3.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACTTCTGGACGGCCCTGCAGG	0.612													45	63	---	---	---	---	PASS
MRC2	9902	broad.mit.edu	37	17	60753805	60753805	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:60753805G>T	uc002jad.2	+	11	2149	c.1747G>T	c.(1747-1749)GCC>TCC	p.A583S	MRC2_uc002jac.2_Missense_Mutation_p.A583S|MRC2_uc010ddq.1_RNA	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	583	Extracellular (Potential).|C-type lectin 3.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTTCTGGACGGCCCTGCAGGA	0.612													45	63	---	---	---	---	PASS
HELZ	9931	broad.mit.edu	37	17	65134182	65134182	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:65134182C>A	uc010wqk.1	-	22	3008	c.2821G>T	c.(2821-2823)GTA>TTA	p.V941L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.V940L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CCCCACGCTACTGGCCACTTC	0.398													48	80	---	---	---	---	PASS
GRIN2C	2905	broad.mit.edu	37	17	72842296	72842296	+	Silent	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:72842296G>C	uc002jlt.1	-	11	2415	c.2259C>G	c.(2257-2259)GTC>GTG	p.V753V	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.V753V	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	753	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGGTAGCAAAGACCTTGCCAG	0.587													7	146	---	---	---	---	PASS
GRIN2C	2905	broad.mit.edu	37	17	72846477	72846477	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:72846477G>A	uc002jlt.1	-	6	1515	c.1359C>T	c.(1357-1359)TGC>TGT	p.C453C	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.C453C	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	453	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ATCCCTTACAGCAGAGCTTGG	0.617													100	118	---	---	---	---	PASS
C17orf28	283987	broad.mit.edu	37	17	72955976	72955976	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:72955976C>T	uc002jmj.3	-	8	1157	c.1008G>A	c.(1006-1008)GAG>GAA	p.E336E	C17orf28_uc010wrs.1_Silent_p.E135E|C17orf28_uc002jmk.2_Silent_p.E335E	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	336						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					CTGGACTTGCCTCCTCACGAT	0.602													98	104	---	---	---	---	PASS
CCDC40	55036	broad.mit.edu	37	17	78073416	78073416	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:78073416C>A	uc010dht.2	+	20	3298	c.3271C>A	c.(3271-3273)CAG>AAG	p.Q1091K	CCDC40_uc002jxm.3_Missense_Mutation_p.Q874K|CCDC40_uc002jxn.3_Missense_Mutation_p.Q487K|GAA_uc002jxo.2_5'Flank|GAA_uc002jxp.2_5'Flank|GAA_uc002jxq.2_5'Flank	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1091					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCGCTCCAAGCAGTCCCTAGT	0.632													4	68	---	---	---	---	PASS
AZI1	22994	broad.mit.edu	37	17	79164546	79164546	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr17:79164546C>A	uc002jzp.1	-	24	3209	c.3009G>T	c.(3007-3009)GAG>GAT	p.E1003D	AZI1_uc002jzm.1_Missense_Mutation_p.E435D|AZI1_uc002jzn.1_Missense_Mutation_p.E1000D|AZI1_uc002jzo.1_Missense_Mutation_p.E964D|AZI1_uc010wum.1_Missense_Mutation_p.E967D|AZI1_uc002jzq.2_Missense_Mutation_p.E151D	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	1003					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GGTCCTCGAACTCCTGGCGGA	0.692													6	37	---	---	---	---	PASS
MYOM1	8736	broad.mit.edu	37	18	3215167	3215167	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:3215167T>C	uc002klp.2	-	2	389	c.55A>G	c.(55-57)AAC>GAC	p.N19D	MYOM1_uc002klq.2_Missense_Mutation_p.N19D	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	19						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ACGTCCTTGTTGCGGTAGCTG	0.587													17	38	---	---	---	---	PASS
LAMA1	284217	broad.mit.edu	37	18	6943182	6943182	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:6943182G>C	uc002knm.2	-	62	9158	c.9064C>G	c.(9064-9066)CCT>GCT	p.P3022A	LAMA1_uc002knk.2_Missense_Mutation_p.P352A|LAMA1_uc002knl.2_Missense_Mutation_p.P475A|LAMA1_uc010wzj.1_Missense_Mutation_p.P2498A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	3022	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACATACCAGGATAGCCACCA	0.498													31	69	---	---	---	---	PASS
KIAA0802	23255	broad.mit.edu	37	18	8784453	8784453	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:8784453G>T	uc002knr.2	+	6	1485	c.1343G>T	c.(1342-1344)CGG>CTG	p.R448L	KIAA0802_uc002knq.2_Missense_Mutation_p.R448L|KIAA0802_uc010dkw.1_Missense_Mutation_p.R286L	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	799											0						CTGAAGGCCCGGGAGGACTCT	0.622													63	119	---	---	---	---	PASS
TAF4B	6875	broad.mit.edu	37	18	23866131	23866131	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:23866131G>A	uc002kvu.3	+	7	1747	c.1258G>A	c.(1258-1260)GCA>ACA	p.A420T	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.A420T	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	420					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			CCCAACTGCTGCAACAGGAGG	0.507													33	83	---	---	---	---	PASS
RIT2	6014	broad.mit.edu	37	18	40503645	40503645	+	Silent	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:40503645T>A	uc002lav.2	-	4	491	c.318A>T	c.(316-318)TCA>TCT	p.S106S	RIT2_uc010dnf.2_Silent_p.S106S	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	106					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						CCTCCTGAAATGATTGACGGT	0.483													117	261	---	---	---	---	PASS
SLC14A1	6563	broad.mit.edu	37	18	43314309	43314309	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:43314309G>T	uc010xcn.1	+	6	731	c.412G>T	c.(412-414)GAC>TAC	p.D138Y	SLC14A1_uc010dnk.2_Missense_Mutation_p.D194Y|SLC14A1_uc002lbf.3_Missense_Mutation_p.D138Y|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.D33Y|SLC14A1_uc002lbh.3_Missense_Mutation_p.D30Y|SLC14A1_uc002lbi.3_Missense_Mutation_p.D6Y|SLC14A1_uc002lbj.3_Missense_Mutation_p.D194Y|SLC14A1_uc002lbk.3_Missense_Mutation_p.D138Y	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	138						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						TGTCTTTTCGGACAAGGGAGA	0.448													55	132	---	---	---	---	PASS
KIAA0427	9811	broad.mit.edu	37	18	46284498	46284498	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:46284498G>A	uc002ldc.2	+	8	1078	c.793G>A	c.(793-795)GCA>ACA	p.A265T	KIAA0427_uc002ldd.2_Missense_Mutation_p.A265T|KIAA0427_uc002lde.3_5'Flank	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	265	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						CAAGGGGGAGGCAGGCGCACA	0.647													20	56	---	---	---	---	PASS
ALPK2	115701	broad.mit.edu	37	18	56246255	56246255	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr18:56246255G>A	uc002lhj.3	-	4	1967	c.1753C>T	c.(1753-1755)CAC>TAC	p.H585Y		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	585							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GCTGTGGTGTGAGAAGTCTCT	0.488											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	84	---	---	---	---	PASS
CELF5	60680	broad.mit.edu	37	19	3278102	3278102	+	Silent	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:3278102C>T	uc002lxm.2	+	5	634	c.597C>T	c.(595-597)ACC>ACT	p.T199T	CELF5_uc002lxl.1_Silent_p.T199T|CELF5_uc010dtj.1_Silent_p.T199T|CELF5_uc010xhg.1_Silent_p.T85T|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	199	RRM 2.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						GGAGCCAGACCATGCCGGTGA	0.617													9	21	---	---	---	---	PASS
FSD1	79187	broad.mit.edu	37	19	4323157	4323157	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:4323157C>A	uc002lzy.2	+	11	1367	c.1214C>A	c.(1213-1215)GCC>GAC	p.A405D	FSD1_uc002lzz.2_Intron|FSD1_uc002maa.2_Missense_Mutation_p.A218D	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	405	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTTCACGGCCAAGCACGCC	0.667													27	49	---	---	---	---	PASS
ACTL9	284382	broad.mit.edu	37	19	8808441	8808441	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:8808441T>C	uc002mkl.2	-	1	732	c.611A>G	c.(610-612)TAC>TGC	p.Y204C		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	204						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						GGGCACTGTGTAGGTGACCCC	0.667													34	53	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9064008	9064008	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:9064008G>A	uc002mkp.2	-	3	23642	c.23438C>T	c.(23437-23439)CCT>CTT	p.P7813L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7815	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGGAAGGCAGGAGTTGATGT	0.537													49	136	---	---	---	---	PASS
C3P1	388503	broad.mit.edu	37	19	10158116	10158116	+	RNA	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:10158116C>T	uc010dwx.1	+	11		c.1559C>T				NR_027300				Synthetic construct DNA, clone: pF1KB7402, Homo sapiens LOC388503 gene, without stop codon, in Flexi system.												0						TGTACAATTTCAGGGATCGCC	0.438													39	122	---	---	---	---	PASS
ATG4D	84971	broad.mit.edu	37	19	10662585	10662585	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:10662585T>C	uc002mov.2	+	7	1099	c.979T>C	c.(979-981)TGC>CGC	p.C327R	ATG4D_uc010xlh.1_Missense_Mutation_p.C264R|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_5'UTR|MIR1238_hsa-mir-1238|MI0006328_5'Flank	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	327					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			ACTCCTGCGTTGCGAGCTGTG	0.348													14	24	---	---	---	---	PASS
CHERP	10523	broad.mit.edu	37	19	16632349	16632349	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:16632349G>C	uc002nei.1	-	12	2171	c.2097C>G	c.(2095-2097)CAC>CAG	p.H699Q	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.H238Q	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	699					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						TGGGCCTGTCGTGGGACGGGG	0.672													8	21	---	---	---	---	PASS
ANO8	57719	broad.mit.edu	37	19	17438618	17438618	+	Silent	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:17438618G>T	uc002ngf.2	-	14	2457	c.2298C>A	c.(2296-2298)CCC>CCA	p.P766P	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	766	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(3)	3						GCGCCGCCAGGGGGAAGGCGG	0.652													50	112	---	---	---	---	PASS
ZNF714	148206	broad.mit.edu	37	19	21300974	21300974	+	Nonsense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:21300974C>T	uc002npo.3	+	6	1867	c.1507C>T	c.(1507-1509)CAG>TAG	p.Q503*	ZNF714_uc002npl.2_Nonsense_Mutation_p.Q348*|ZNF714_uc010ecp.1_Nonsense_Mutation_p.Q454*|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	503	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGAAAATTCAgcagggcat	0.154													9	15	---	---	---	---	PASS
ZNF714	148206	broad.mit.edu	37	19	21300975	21300975	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:21300975A>G	uc002npo.3	+	6	1868	c.1508A>G	c.(1507-1509)CAG>CGG	p.Q503R	ZNF714_uc002npl.2_Missense_Mutation_p.Q348R|ZNF714_uc010ecp.1_Missense_Mutation_p.Q454R|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	503	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGAAAATTCAgcagggcatg	0.154													9	15	---	---	---	---	PASS
ZNF431	170959	broad.mit.edu	37	19	21366002	21366002	+	Missense_Mutation	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:21366002G>C	uc002npp.2	+	5	1043	c.896G>C	c.(895-897)CGG>CCG	p.R299P	ZNF431_uc010ecq.2_Missense_Mutation_p.R208P|ZNF431_uc010ecr.2_Missense_Mutation_p.R300P	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	299	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCTTCAACCGGTCCTCACAC	0.408													18	50	---	---	---	---	PASS
ZNF429	353088	broad.mit.edu	37	19	21720399	21720399	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:21720399G>A	uc002nqd.1	+	4	1681	c.1544G>A	c.(1543-1545)GGC>GAC	p.G515D	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	515	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GAAGAATGTGGCAAAGCTTTT	0.368													12	32	---	---	---	---	PASS
PPFIA3	8541	broad.mit.edu	37	19	49631295	49631295	+	Silent	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:49631295A>G	uc002pmr.2	+	2	497	c.165A>G	c.(163-165)ACA>ACG	p.T55T	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_5'Flank|PPFIA3_uc010yaj.1_5'Flank|PPFIA3_uc002pms.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	55	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GGTTGGCTACAGCGCAGCTGC	0.726													12	11	---	---	---	---	PASS
NLRP4	147945	broad.mit.edu	37	19	56369695	56369695	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr19:56369695C>G	uc002qmd.3	+	3	1358	c.936C>G	c.(934-936)TGC>TGG	p.C312W	NLRP4_uc002qmf.2_Missense_Mutation_p.C237W|NLRP4_uc010etf.2_Missense_Mutation_p.C143W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	312	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGTATTTCTGCTGTTTCTTCA	0.493													4	80	---	---	---	---	PASS
SPATA2	9825	broad.mit.edu	37	20	48524716	48524716	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr20:48524716C>A	uc010gie.2	-	2	662	c.312G>T	c.(310-312)TGG>TGT	p.W104C	SPATA2_uc002xuw.2_Missense_Mutation_p.W104C|SPATA2_uc010zyn.1_Intron	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	104					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			ATTCCTTCTTCCACGGGTAGA	0.602													37	138	---	---	---	---	PASS
TMEM189-UBE2V1	387522	broad.mit.edu	37	20	48746194	48746194	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr20:48746194C>G	uc002xvf.2	-	4	528	c.367G>C	c.(367-369)GAC>CAC	p.D123H	TMEM189_uc010zyq.1_RNA|TMEM189_uc002xvg.2_Missense_Mutation_p.D123H|TMEM189_uc010gif.2_Missense_Mutation_p.D120H|TMEM189_uc010zyp.1_Missense_Mutation_p.D48H	NM_199203	NP_954673	Q13404	UB2V1_HUMAN	TMEM189-UBE2V1 readthrough transcript	Error:Variant_position_missing_in_Q13404_after_alignment					cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)			GCTGTCGGGTCAATGTGGTGC	0.602													6	119	---	---	---	---	PASS
CDH26	60437	broad.mit.edu	37	20	58559798	58559798	+	Missense_Mutation	SNP	A	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr20:58559798A>C	uc002ybe.2	+	6	946	c.646A>C	c.(646-648)AGT>CGT	p.S216R	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	216	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			ACTGAAAGAAAGTGGTTTCCG	0.358													82	85	---	---	---	---	PASS
RBM11	54033	broad.mit.edu	37	21	15591904	15591904	+	Silent	SNP	G	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr21:15591904G>C	uc002yjo.3	+	2	159	c.117G>C	c.(115-117)GTG>GTC	p.V39V	RBM11_uc002yjn.3_5'UTR|RBM11_uc002yjp.3_Intron	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	39	RRM.						nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		TAACCAAAGTGACTATATGCA	0.338													4	13	---	---	---	---	PASS
KRTAP13-3	337960	broad.mit.edu	37	21	31798087	31798087	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr21:31798087C>A	uc002yob.1	-	1	144	c.144G>T	c.(142-144)CTG>CTT	p.L48L		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	48	1.|5 X 10 AA approximate repeats.					intermediate filament				ovary(1)|lung(1)	2						GAGAGGAACCCAGCTGGCAGG	0.597													30	78	---	---	---	---	PASS
DSCAM	1826	broad.mit.edu	37	21	41414584	41414584	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr21:41414584G>T	uc002yyq.1	-	32	5852	c.5400C>A	c.(5398-5400)AGC>AGA	p.S1800R	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1800	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAGACCATGCTGCTTCTTG	0.542													16	52	---	---	---	---	PASS
KRTAP10-9	386676	broad.mit.edu	37	21	46047883	46047883	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr21:46047883C>A	uc002zfp.3	+	1	844	c.795C>A	c.(793-795)GCC>GCA	p.A265A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	265						keratin filament					0						GCCGCCAGGCCTCCTGTGTGT	0.697													51	106	---	---	---	---	PASS
TSSK2	23617	broad.mit.edu	37	22	19119491	19119491	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr22:19119491G>T	uc002zow.2	+	1	1171	c.579G>T	c.(577-579)CAG>CAT	p.Q193H	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	193	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					TCCCCTACCAGCCCAAGGTGT	0.602													14	150	---	---	---	---	PASS
TXNRD2	10587	broad.mit.edu	37	22	19864720	19864720	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr22:19864720C>A	uc011ahc.1	-	17	1516	c.1483G>T	c.(1483-1485)GGT>TGT	p.G495C	TXNRD2_uc002zql.1_Missense_Mutation_p.G249C|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Missense_Mutation_p.G494C|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Missense_Mutation_p.G145C	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	495					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GGATGGATACCCACGGTCCGC	0.652													13	39	---	---	---	---	PASS
RFPL1	5988	broad.mit.edu	37	22	29837976	29837976	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr22:29837976C>A	uc003afn.2	+	2	1028	c.819C>A	c.(817-819)GTC>GTA	p.V273V	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	273	B30.2/SPRY.						zinc ion binding				0						TCAGGAGTGTCTCTGCTGAGG	0.468													5	173	---	---	---	---	PASS
CCDC157	550631	broad.mit.edu	37	22	30766590	30766590	+	Silent	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr22:30766590G>A	uc011aku.1	+	5	1356	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	CCDC157_uc011akv.1_Silent_p.Q232Q	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	232										central_nervous_system(1)	1						GAAGCCTGCAGAAGGTGGGCA	0.622													7	107	---	---	---	---	PASS
MOSPD2	158747	broad.mit.edu	37	X	14936842	14936842	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:14936842C>G	uc004cwi.2	+	14	1445	c.1357C>G	c.(1357-1359)CTT>GTT	p.L453V	MOSPD2_uc004cwj.2_Missense_Mutation_p.L390V	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	453						integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					ACCAAACACTCTTACGTTAAA	0.279													33	77	---	---	---	---	PASS
ACE2	59272	broad.mit.edu	37	X	15605982	15605982	+	Splice_Site	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:15605982C>T	uc004cxa.1	-	6	865	c.697_splice	c.e6-1	p.I233_splice	ACE2_uc004cxb.2_Splice_Site_p.I233_splice	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor						angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	ATGGTTTAATCTGAAAAGCCC	0.368													7	75	---	---	---	---	PASS
PHKA2	5256	broad.mit.edu	37	X	18963197	18963197	+	Missense_Mutation	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:18963197T>C	uc004cyv.3	-	6	1047	c.617A>G	c.(616-618)AAG>AGG	p.K206R	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_Missense_Mutation_p.K148R	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	206					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					AACTGTCACCTTGGCCATTCC	0.438													28	65	---	---	---	---	PASS
PDK3	5165	broad.mit.edu	37	X	24544369	24544369	+	Missense_Mutation	SNP	A	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:24544369A>G	uc004dbg.2	+	7	957	c.728A>G	c.(727-729)CAT>CGT	p.H243R	PDK3_uc004dbh.2_Missense_Mutation_p.H243R	NM_005391	NP_005382	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase 3 isoform 2	243	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						CATCTGTTTCATATGCTATTT	0.368													18	44	---	---	---	---	PASS
POLA1	5422	broad.mit.edu	37	X	24766501	24766501	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:24766501G>A	uc004dbl.2	+	25	2770	c.2747G>A	c.(2746-2748)CGG>CAG	p.R916Q		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	916					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	AGAGAGATCCGGAAACTGGTA	0.284													11	38	---	---	---	---	PASS
DMD	1756	broad.mit.edu	37	X	32366646	32366646	+	Splice_Site	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:32366646C>T	uc004dda.1	-	38	5570	c.5326_splice	c.e38-1	p.A1776_splice	DMD_uc004dcw.2_Splice_Site_p.A432_splice|DMD_uc004dcx.2_Splice_Site_p.A435_splice|DMD_uc004dcz.2_Splice_Site_p.A1653_splice|DMD_uc004dcy.1_Splice_Site_p.A1772_splice|DMD_uc004ddb.1_Splice_Site_p.A1768_splice|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GAATGGAGGCCTAAAAAAAAA	0.333													14	21	---	---	---	---	PASS
FAM47A	158724	broad.mit.edu	37	X	34149282	34149282	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:34149282C>A	uc004ddg.2	-	1	1147	c.1114G>T	c.(1114-1116)GGG>TGG	p.G372W		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	372										ovary(4)|central_nervous_system(1)	5						AGACTGGACCCCCGACGAGTC	0.632													22	50	---	---	---	---	PASS
FAM47B	170062	broad.mit.edu	37	X	34961596	34961596	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:34961596C>A	uc004ddi.1	+	1	666	c.648C>A	c.(646-648)CCC>CCA	p.P216P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	216	Pro-rich.									ovary(3)|breast(1)	4						CAGAGCCTCCCAAGACTCGGG	0.672													25	63	---	---	---	---	PASS
MED14	9282	broad.mit.edu	37	X	40513614	40513614	+	Splice_Site	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:40513614A>T	uc004dex.3	-	30	4431	c.4291_splice	c.e30+1	p.G1431_splice	MED14_uc004dey.1_Silent_p.G333G	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						CTGGTCATGTACCTTGTCGTG	0.433													14	72	---	---	---	---	PASS
HUWE1	10075	broad.mit.edu	37	X	53592131	53592131	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:53592131C>G	uc004dsp.2	-	50	7179	c.6777G>C	c.(6775-6777)CAG>CAC	p.Q2259H	HUWE1_uc004dsn.2_Missense_Mutation_p.Q1083H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2259					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GGCTACTGGGCTGGTTCACAA	0.502													19	75	---	---	---	---	PASS
ITIH5L	347365	broad.mit.edu	37	X	54780108	54780108	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:54780108G>T	uc004dtj.2	-	11	3358	c.3328C>A	c.(3328-3330)CAG>AAG	p.Q1110K		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1110					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						TCTATGAGCTGCAGCAAGTCC	0.522													23	63	---	---	---	---	PASS
TRO	7216	broad.mit.edu	37	X	54950182	54950182	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:54950182G>A	uc004dtq.2	+	3	1324	c.1217G>A	c.(1216-1218)CGG>CAG	p.R406Q	TRO_uc011moj.1_Missense_Mutation_p.R349Q|TRO_uc004dts.2_Missense_Mutation_p.R406Q|TRO_uc004dtr.2_Missense_Mutation_p.R406Q|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	406					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ACCAGGACCCGGGGCAAAAGA	0.473													14	44	---	---	---	---	PASS
ZXDB	158586	broad.mit.edu	37	X	57619097	57619097	+	Missense_Mutation	SNP	G	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:57619097G>A	uc004dvd.2	+	1	829	c.616G>A	c.(616-618)GGG>AGG	p.G206R		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CCAGCAGCCCGGGTGTCTGAT	0.711													3	44	---	---	---	---	PASS
SNX12	29934	broad.mit.edu	37	X	70288146	70288146	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:70288146G>T	uc004dyr.1	-	1	86	c.11C>A	c.(10-12)ACG>AAG	p.T4K	SNX12_uc004dyp.1_RNA	NM_013346	NP_037478	Q9UMY4	SNX12_HUMAN	sorting nexin 12	4					cell communication|protein transport	membrane	phosphatidylinositol binding|protein binding				0	Renal(35;0.156)					AGCTACTGCCGTGTCCGACAT	0.617													11	16	---	---	---	---	PASS
CXorf65	158830	broad.mit.edu	37	X	70323957	70323957	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:70323957C>A	uc011mpo.1	-	6	446	c.432G>T	c.(430-432)AAG>AAT	p.K144N	CXorf65_uc011mpp.1_Missense_Mutation_p.K96N	NM_001025265	NP_001020436	A6NEN9	CX065_HUMAN	hypothetical protein LOC158830	144										central_nervous_system(1)	1						GTCCTGATTGCTTGGACTAGA	0.443													23	41	---	---	---	---	PASS
ZMYM3	9203	broad.mit.edu	37	X	70469495	70469495	+	Missense_Mutation	SNP	T	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:70469495T>G	uc004dzh.1	-	7	1373	c.1286A>C	c.(1285-1287)CAC>CCC	p.H429P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.H429P|ZMYM3_uc004dzj.1_Missense_Mutation_p.H429P|ZMYM3_uc011mpu.1_Missense_Mutation_p.H160P|ZMYM3_uc004dzk.3_Missense_Mutation_p.H429P|ZMYM3_uc004dzl.3_Missense_Mutation_p.H429P|ZMYM3_uc004dzm.3_Missense_Mutation_p.H429P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	429	MYM-type 3.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GCAGAGCCGGTGTACCACGCT	0.582													7	84	---	---	---	---	PASS
RLIM	51132	broad.mit.edu	37	X	73812546	73812546	+	Missense_Mutation	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:73812546C>A	uc004ebu.2	-	5	894	c.604G>T	c.(604-606)GTC>TTC	p.V202F	RLIM_uc004ebw.2_Missense_Mutation_p.V202F	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	202					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GTAGGTGGGACCTCTGTTAAC	0.498													56	333	---	---	---	---	PASS
ARL13A	392509	broad.mit.edu	37	X	100242485	100242485	+	Missense_Mutation	SNP	C	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:100242485C>T	uc004ego.2	+	6	709	c.593C>T	c.(592-594)ACC>ATC	p.T198I	ARL13A_uc011mrf.1_Missense_Mutation_p.T198I|ARL13A_uc010nng.2_Missense_Mutation_p.T198I	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	198							GTP binding			ovary(1)	1						CTACCACCTACCTCGAGCATC	0.453													11	155	---	---	---	---	PASS
TEX13A	56157	broad.mit.edu	37	X	104464650	104464650	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:104464650G>T	uc004ema.2	-	2	544	c.432C>A	c.(430-432)GAC>GAA	p.D144E	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.D144E	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	144						intracellular	zinc ion binding			ovary(2)	2						AACTCACCTTGTCTCTCTCTT	0.478													40	57	---	---	---	---	PASS
NRK	203447	broad.mit.edu	37	X	105153033	105153033	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:105153033C>G	uc004emd.2	+	13	1703	c.1400C>G	c.(1399-1401)GCA>GGA	p.A467G	NRK_uc010npc.1_Missense_Mutation_p.A135G	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	467	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CAGATTAAGGCACCTCCACGA	0.552										HNSCC(51;0.14)			29	41	---	---	---	---	PASS
NRK	203447	broad.mit.edu	37	X	105168796	105168796	+	Nonsense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:105168796G>T	uc004emd.2	+	19	3388	c.3085G>T	c.(3085-3087)GGA>TGA	p.G1029*	NRK_uc010npc.1_Nonsense_Mutation_p.G697*	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1029							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TAGAAGCCATGGAGGAAGTGC	0.502										HNSCC(51;0.14)			25	25	---	---	---	---	PASS
IRS4	8471	broad.mit.edu	37	X	107979218	107979218	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:107979218C>A	uc004eoc.2	-	1	390	c.357G>T	c.(355-357)CGG>CGT	p.R119R		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	119	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGACACTGTGCCGGAACTTCC	0.652													31	72	---	---	---	---	PASS
DOCK11	139818	broad.mit.edu	37	X	117743289	117743289	+	Missense_Mutation	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:117743289T>A	uc004eqp.2	+	27	2989	c.2926T>A	c.(2926-2928)TTG>ATG	p.L976M	DOCK11_uc004eqq.2_Missense_Mutation_p.L742M	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	976					blood coagulation	cytosol	GTP binding			ovary(3)	3						GGCCACATACTTGTTGGAAGA	0.279													41	141	---	---	---	---	PASS
UBE2A	7319	broad.mit.edu	37	X	118717208	118717208	+	Missense_Mutation	SNP	G	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:118717208G>T	uc004erl.2	+	6	625	c.449G>T	c.(448-450)CGT>CTT	p.R150L	UBE2A_uc004erm.2_Missense_Mutation_p.R120L|UBE2A_uc004ern.2_RNA|UBE2A_uc004ero.2_RNA|UBE2A_uc004erp.2_Missense_Mutation_p.R75L	NM_003336	NP_003327	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A isoform 1	150					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						CAAAGCTGGCGTGATTGTTGA	0.423								Direct_reversal_of_damage|Rad6_pathway					40	190	---	---	---	---	PASS
HS6ST2	90161	broad.mit.edu	37	X	131762512	131762512	+	Silent	SNP	T	C	C			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:131762512T>C	uc011mve.1	-	4	1973	c.1557A>G	c.(1555-1557)AAA>AAG	p.K519K	HS6ST2_uc011mvb.1_Silent_p.K413K|HS6ST2_uc011mvc.1_Silent_p.K373K|HS6ST2_uc011mvd.1_Silent_p.K559K|HS6ST2_uc011mva.1_Silent_p.K245K	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	519	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					CCTTCAGAAATTTGCGTTGTT	0.373													38	118	---	---	---	---	PASS
GPR112	139378	broad.mit.edu	37	X	135432363	135432363	+	Silent	SNP	T	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:135432363T>A	uc004ezu.1	+	6	6789	c.6498T>A	c.(6496-6498)TCT>TCA	p.S2166S	GPR112_uc010nsb.1_Silent_p.S1961S|GPR112_uc010nsc.1_Silent_p.S1933S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2166	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATCACCCTCTACTTTAATTA	0.443													48	151	---	---	---	---	PASS
MAGEC1	9947	broad.mit.edu	37	X	140995353	140995353	+	Silent	SNP	C	A	A			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:140995353C>A	uc004fbt.2	+	4	2449	c.2163C>A	c.(2161-2163)CTC>CTA	p.L721L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	721							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTCTCTCCTCTCC	0.542										HNSCC(15;0.026)			67	235	---	---	---	---	PASS
UBE2NL	389898	broad.mit.edu	37	X	142967587	142967587	+	Missense_Mutation	SNP	C	G	G			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:142967587C>G	uc004fca.2	+	1	415	c.385C>G	c.(385-387)CAG>GAG	p.Q129E		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	129							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					TGTAGTGGAGCAGTGGAAGAC	0.463													41	147	---	---	---	---	PASS
ZNF185	7739	broad.mit.edu	37	X	152128349	152128349	+	Missense_Mutation	SNP	A	T	T			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:152128349A>T	uc010ntv.1	+	17	1550	c.1513A>T	c.(1513-1515)ACT>TCT	p.T505S	ZNF185_uc011myg.1_Missense_Mutation_p.T537S|ZNF185_uc011myh.1_Missense_Mutation_p.T508S|ZNF185_uc011myi.1_Missense_Mutation_p.T476S|ZNF185_uc011myj.1_Missense_Mutation_p.T446S|ZNF185_uc011myk.1_Missense_Mutation_p.T506S|ZNF185_uc004fgw.3_Missense_Mutation_p.T284S|ZNF185_uc004fgu.2_Missense_Mutation_p.T134S|ZNF185_uc004fgv.2_Missense_Mutation_p.T202S|ZNF185_uc004fgx.2_Missense_Mutation_p.T143S	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	505						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGCTGTACCCACTCAGCAACC	0.607													9	51	---	---	---	---	PASS
KIAA0196	9897	broad.mit.edu	37	8	126049491	126049494	+	Frame_Shift_Del	DEL	TGTA	-	-			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr8:126049491_126049494delTGTA	uc003yrt.2	-	26	3495_3498	c.3166_3169delTACA	c.(3166-3171)TACAACfs	p.Y1056fs	KIAA0196_uc011lir.1_Frame_Shift_Del_p.Y908fs|KIAA0196_uc003yru.1_Frame_Shift_Del_p.Y630fs	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	1056_1057					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGATTTTTGTTGTATTGAAGTTTT	0.304													81	39	---	---	---	---	
IGSF9B	22997	broad.mit.edu	37	11	133801456	133801456	+	Frame_Shift_Del	DEL	G	-	-			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chr11:133801456delG	uc001qgx.3	-	10	1491	c.1260delC	c.(1258-1260)CCCfs	p.P420fs	IGSF9B_uc001qgy.1_Frame_Shift_Del_p.P262fs	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	420	Extracellular (Potential).|Ig-like 5.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGTGAAATAGGGGGGGTCCT	0.652													24	18	---	---	---	---	
MAGEE2	139599	broad.mit.edu	37	X	75003354	75003354	+	Frame_Shift_Del	DEL	T	-	-			TCGA-43-6770-01A-11D-1817-08	TCGA-43-6770-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	404ca8c2-f1bb-4749-8abd-87f491a8111c	c110c1d0-f64c-4bdf-b3b2-a6fc4f5bbc61	g.chrX:75003354delT	uc004ecj.1	-	1	1718	c.1533delA	c.(1531-1533)AAAfs	p.K511fs		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	511										ovary(1)|skin(1)	2						TTGCCTCAGATTTGGCTCTGG	0.463													124	72	---	---	---	---	
