Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ZMYM6	9204	broad.mit.edu	37	1	35453123	35453123	+	Missense_Mutation	SNP	A	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:35453123A>C	uc001byh.2	-	16	3788	c.3560T>G	c.(3559-3561)ATT>AGT	p.I1187S	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Missense_Mutation_p.I1090S	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1187					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GTGCTCAAAAATAATCCTTGT	0.299000													9	63					0	0	0	0
RLF	6018	broad.mit.edu	37	1	40703347	40703347	+	Silent	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:40703347A>G	uc001cfc.3	+	8	3004	c.2973A>G	c.(2971-2973)AAA>AAG	p.K991K	RLF_uc001cfd.3_Silent_p.K682K	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	991					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TAAAGACGAAAGATCTGTTTC	0.408000													14	43					0	0	0	0
ERMAP	114625	broad.mit.edu	37	1	43305715	43305715	+	Missense_Mutation	SNP	A	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:43305715A>T	uc001cic.1	+	9	919	c.649A>T	c.(649-651)AGT>TGT	p.S217C	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.S217C|ERMAP_uc001cif.1_Missense_Mutation_p.S127C	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	217	Cytoplasmic (Potential).		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAAACTCCGGAGTGAACTGAG	0.438000													45	129					0	0	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70758091	70758091	+	Missense_Mutation	SNP	T	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:70758091T>G	uc001dex.3	-	9	1521	c.1195A>C	c.(1195-1197)ATA>CTA	p.I399L	ANKRD13C_uc009wbk.2_Missense_Mutation_p.I364L	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	399					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						TGTTCCATTATGTTTCCACCT	0.338000													15	57					0	0	0	0
CASQ2	845	broad.mit.edu	37	1	116280931	116280931	+	Missense_Mutation	SNP	A	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:116280931A>C	uc001efx.3	-	4	710	c.446T>G	c.(445-447)ATC>AGC	p.I149S	CASQ2_uc010owu.1_Intron	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	149					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTTGCTGCTGATGATCTCCAC	0.443000													47	121					0	0	0	0
ZNF687	57592	broad.mit.edu	37	1	151259824	151259824	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:151259824C>T	uc001exq.2	+	2	1155	c.1057C>T	c.(1057-1059)CCT>TCT	p.P353S	ZNF687_uc001exp.1_Missense_Mutation_p.P362S|ZNF687_uc009wmo.2_Missense_Mutation_p.P353S|ZNF687_uc009wmp.2_Missense_Mutation_p.P353S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCCTCAGATCCTGATCCACC	0.562000													29	65					0	0	0	0
ADAM15	8751	broad.mit.edu	37	1	155034393	155034393	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:155034393A>G	uc001fgr.1	+	21	2467	c.2366A>G	c.(2365-2367)GAC>GGC	p.D789G	EFNA3_uc010pew.1_5'Flank|ADAM15_uc001fgq.1_Missense_Mutation_p.D473G|ADAM15_uc001fgt.1_Missense_Mutation_p.D788G|ADAM15_uc010pev.1_Intron|ADAM15_uc001fgs.1_Intron|ADAM15_uc001fgu.1_Missense_Mutation_p.D764G|ADAM15_uc001fgw.1_Intron|ADAM15_uc001fgv.1_Intron|ADAM15_uc001fgx.1_Intron|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_Intron|EFNA4_uc001fhc.2_5'Flank|EFNA4_uc001fhd.2_5'Flank|EFNA4_uc001fhe.2_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	789	Cytoplasmic (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAGCTGGCTGACCGACCCAAT	0.642000											OREG0013848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	145					0	0	0	0
BCAN	63827	broad.mit.edu	37	1	156618415	156618415	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:156618415G>A	uc001fpp.2	+	6	1161	c.825G>A	c.(823-825)GCG>GCA	p.A275A	BCAN_uc001fpo.2_Silent_p.A275A	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	275	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AAGCACGGGCGTACTGCCAGG	0.498000													24	126					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196658702	196658702	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:196658702C>T	uc001gtj.3	+	8	1357	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	CFH_uc001gti.3_Missense_Mutation_p.H373Y|CFH_uc009wyw.2_Missense_Mutation_p.H348Y|CFH_uc009wyx.2_Missense_Mutation_p.H309Y	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	373	Sushi 6.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGATCACATTCATTGCACACA	0.393000													9	130					0	0	0	0
URB2	9816	broad.mit.edu	37	1	229773396	229773396	+	Silent	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:229773396C>A	uc001hts.1	+	4	3172	c.3036C>A	c.(3034-3036)CTC>CTA	p.L1012L	URB2_uc009xfd.1_Silent_p.L1012L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1012						nucleolus				central_nervous_system(2)|ovary(1)	3						TGCAGATGCTCATCCAAATGA	0.448000													26	49					1.64293e-13	1.99609e-13	1	0
OR2C3	81472	broad.mit.edu	37	1	247695697	247695697	+	Silent	SNP	C	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:247695697C>G	uc009xgy.2	-	2	479	c.117G>C	c.(115-117)TCG>TCC	p.S39S	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGCCCAAGATCGATACCATGT	0.473000													25	109					0	0	0	0
OR5I1	10798	broad.mit.edu	37	11	55703033	55703033	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:55703033T>C	uc010ris.1	-	1	844	c.844A>G	c.(844-846)ATT>GTT	p.I282V		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAATGAAAATGGTGTAGAAC	0.383000													12	26					0	0	0	0
MS4A12	54860	broad.mit.edu	37	11	60264874	60264874	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:60264874C>A	uc001npr.2	+	2	140	c.83C>A	c.(82-84)CCT>CAT	p.P28H	MS4A12_uc009ynb.2_Missense_Mutation_p.P28H	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	28	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TTTATGGCTCCTGGATTTCAA	0.478000													27	83					2.48779e-11	2.96709e-11	1	0
PC	5091	broad.mit.edu	37	11	66617874	66617874	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:66617874G>A	uc001ojn.1	-	17	2584	c.2535C>T	c.(2533-2535)TAC>TAT	p.Y845Y	PC_uc001ojo.1_Silent_p.Y845Y|PC_uc001ojp.1_Silent_p.Y845Y|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	845					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGAAGGCCGCGTACAGTCCCC	0.597000													9	87					0	0	0	0
MMP8	4317	broad.mit.edu	37	11	102585393	102585393	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:102585393G>A	uc001phe.2	-	8	1183	c.1084C>T	c.(1084-1086)CCC>TCC	p.P362S	MMP8_uc010rut.1_Intron|MMP8_uc010ruu.1_Missense_Mutation_p.P339S	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	362	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATATCCTTGGGATAACCTTGC	0.383000													10	174					0	0	0	0
PARP11	57097	broad.mit.edu	37	12	3935380	3935380	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:3935380G>A	uc001qmk.1	-	3	322	c.267C>T	c.(265-267)CTC>CTT	p.L89L	PARP11_uc001qml.2_Silent_p.L96L|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Silent_p.L15L|PARP11_uc001qmn.2_Silent_p.L15L	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	89	WWE.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			TTCCAGTGGTGAGATTCATTT	0.358000													23	172					0	0	0	0
DPPA3	359787	broad.mit.edu	37	12	7864205	7864205	+	Silent	SNP	G	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:7864205G>T	uc001qtf.2	+	1	117	c.39G>T	c.(37-39)GGG>GGT	p.G13G		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	13						cytoplasm|nucleus					0				Kidney(36;0.0887)		ACATCCCAGGGTCTCCACAAA	0.483000													3	43					0.004672	0.0050195	1	0
PDZRN4	29951	broad.mit.edu	37	12	41966610	41966610	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:41966610G>A	uc010skn.1	+	10	1500	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	PDZRN4_uc001rmq.3_Missense_Mutation_p.E419K|PDZRN4_uc009zjz.2_Missense_Mutation_p.E417K|PDZRN4_uc001rmr.2_Missense_Mutation_p.E304K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	677	Potential.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAGAAACATTGAGCTTGAGTG	0.453000													13	80					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49434544	49434544	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:49434544G>A	uc001rta.3	-	31	7009	c.7009C>T	c.(7009-7011)CAG>TAG	p.Q2337*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2337	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCTCTACCTGAGATGCCCGA	0.627000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	38					0	0	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54936370	54936370	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:54936370G>A	uc001sgc.3	+	31	3364	c.3285G>A	c.(3283-3285)GAG>GAA	p.E1095E	NCKAP1L_uc010sox.1_Silent_p.E637E|NCKAP1L_uc010soy.1_Silent_p.E1045E	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1095					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGGTGGAGGAGTCATCCTTCC	0.527000													18	136					0	0	0	0
LRIG3	121227	broad.mit.edu	37	12	59266402	59266402	+	Missense_Mutation	SNP	T	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:59266402T>G	uc001sqr.2	-	19	3558	c.3312A>C	c.(3310-3312)TTA>TTC	p.L1104F	LRIG3_uc009zqh.2_Missense_Mutation_p.L1044F|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	1104						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGTAGTTTTCTAAAGTCTGTT	0.383000													16	98					0	0	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041067	64041067	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:64041067C>T	uc001srp.1	-	5	848	c.667G>A	c.(667-669)GTC>ATC	p.V223I	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	223					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATTCTGGTGACATTCCAGCAG	0.318000													17	133					0	0	0	0
PIWIL1	9271	broad.mit.edu	37	12	130847537	130847537	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:130847537G>A	uc001uik.2	+	18	2133	c.2043G>A	c.(2041-2043)GCG>GCA	p.A681A	PIWIL1_uc001uij.1_Silent_p.A681A	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	681	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CTGTTTCAGCGGCTCTGAGGG	0.512000													26	62					0	0	0	0
WASF3	10810	broad.mit.edu	37	13	27255411	27255411	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr13:27255411C>T	uc001uqv.2	+	8	1162	c.937C>T	c.(937-939)CCA>TCA	p.P313S	WASF3_uc001uqw.2_Missense_Mutation_p.P310S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	313					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCTCAGGCCCCAGAGGGGTC	0.652000													32	97					0	0	0	0
BRCA2	675	broad.mit.edu	37	13	32936727	32936727	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr13:32936727A>T	uc001uub.1	+	17	8100	c.7873A>T	c.(7873-7875)AGA>TGA	p.R2625*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2625					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TAATCACTATAGATGGATCAT	0.368000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			26	72					0	0	0	0
SPTB	6710	broad.mit.edu	37	14	65239589	65239589	+	Silent	SNP	G	A	A	rs142168941		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:65239589G>A	uc001xht.2	-	25	5316	c.5262C>T	c.(5260-5262)ATC>ATT	p.I1754I	SPTB_uc001xhr.2_Silent_p.I1754I|SPTB_uc001xhs.2_Silent_p.I1754I|SPTB_uc001xhu.2_Silent_p.I1754I|SPTB_uc010aqi.2_Silent_p.I415I	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1754	Spectrin 14.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGAGTCGCTCGATGAAGGCAT	0.637000													12	21					0	0	0	0
ABCD4	5826	broad.mit.edu	37	14	74766262	74766262	+	Missense_Mutation	SNP	G	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:74766262G>C	uc001xpr.2	-	3	426	c.274C>G	c.(274-276)CTG>GTG	p.L92V	ABCD4_uc001xps.2_Intron|ABCD4_uc001xpt.2_Intron|ABCD4_uc010tur.1_Missense_Mutation_p.L5V|ABCD4_uc001xpu.2_5'UTR|ABCD4_uc001xpv.2_Intron	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	92	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GTGGAGTTCAGAACAATGAGC	0.512000													20	72					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	79181301	79181301	+	Missense_Mutation	SNP	G	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:79181301G>C	uc001xun.2	+	5	1235	c.744G>C	c.(742-744)AAG>AAC	p.K248N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.K382N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	621	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGCGCAGCAAGAACATTCGAC	0.557000													11	36					0	0	0	0
LTK	4058	broad.mit.edu	37	15	41797201	41797201	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr15:41797201C>T	uc001zoa.3	-	16	2165	c.1987G>A	c.(1987-1989)GGG>AGG	p.G663R	LTK_uc001zob.3_Missense_Mutation_p.G602R|LTK_uc010ucx.1_Missense_Mutation_p.G533R|LTK_uc010bcg.2_Missense_Mutation_p.G361R	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	663	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCAAAGTCCCCAATCTTGGCC	0.567000										TSP Lung(18;0.14)			11	32					0	0	0	0
THSD4	79875	broad.mit.edu	37	15	72023537	72023538	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr15:72023537_72023538GC>AT	uc002atb.1	+	9	1690_1691	c.1611_1612GC>AT	c.(1609-1614)GTGCCA>GTATCA	p.P538S	THSD4_uc002atd.1_3'UTR|THSD4_uc010ukg.1_Missense_Mutation_p.P178S|THSD4_uc002ate.2_Missense_Mutation_p.P178S	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	538						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GCCCCCAGGTGCCACCCCACAG	0.540000											OREG0023247	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	47					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18881315	18881315	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:18881315T>C	uc002dfm.2	-	19	2857	c.2494A>G	c.(2494-2496)AAT>GAT	p.N832D	SMG1_uc010bwb.2_Missense_Mutation_p.N692D	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	832	Interaction with SMG8 and SMG9.		N -> D.		DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGATTGTTATTGCTGTAGACA	0.318000													5	9					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	20998737	20998737	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:20998737C>T	uc010vbe.1	-	47	6916	c.6916G>A	c.(6916-6918)GAG>AAG	p.E2306K	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2306					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGATAAACCTCATGGATCCAA	0.418000													15	82					0	0	0	0
UBFD1	56061	broad.mit.edu	37	16	23570829	23570829	+	Silent	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:23570829C>T	uc002dlv.2	+	3	598	c.396C>T	c.(394-396)CTC>CTT	p.L132L	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	132	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		ATAAGGGACTCGTCCCCGAGG	0.418000													8	40					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27483198	27483198	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:27483198T>C	uc002dov.1	-	30	4437	c.4397A>G	c.(4396-4398)AAG>AGG	p.K1466R	GTF3C1_uc002dou.2_Missense_Mutation_p.K1466R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1466						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CATGAAGGCCTTCACAAGAAC	0.627000													18	62					0	0	0	0
HPR	3250	broad.mit.edu	37	16	72110554	72110554	+	Silent	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:72110554C>T	uc002fby.2	+	5	651	c.621C>T	c.(619-621)ATC>ATT	p.I207I	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	207	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGATGCCCATCTGCCTACCTT	0.448000													19	141					0	0	0	0
LRRC50	123872	broad.mit.edu	37	16	84203819	84203819	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:84203819A>G	uc002fhl.3	+	8	1566	c.1385A>G	c.(1384-1386)CAA>CGA	p.Q462R	LRRC50_uc010vnw.1_Missense_Mutation_p.Q226R	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	462	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						GATGGAGATCAAGAGCCAGAG	0.612000									Kartagener_syndrome				11	120					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577556	7577556	+	Missense_Mutation	SNP	C	T	T	rs121912655		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:7577556C>T	uc002gim.2	-	7	919	c.725G>A	c.(724-726)TGC>TAC	p.C242Y	TP53_uc002gig.1_Missense_Mutation_p.C242Y|TP53_uc002gih.2_Missense_Mutation_p.C242Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110Y|TP53_uc010cng.1_Missense_Mutation_p.C110Y|TP53_uc002gii.1_Missense_Mutation_p.C110Y|TP53_uc010cnh.1_Missense_Mutation_p.C242Y|TP53_uc010cni.1_Missense_Mutation_p.C242Y|TP53_uc002gij.2_Missense_Mutation_p.C242Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149Y|TP53_uc002gio.2_Missense_Mutation_p.C110Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	62					0	0	0	0
SCO1	6341	broad.mit.edu	37	17	10584496	10584496	+	Silent	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:10584496C>T	uc002gmr.3	-	6	907	c.846G>A	c.(844-846)AGG>AGA	p.R282R	SCO1_uc002gms.3_Silent_p.R251R	NM_004589	NP_004580	O75880	SCO1_HUMAN	cytochrome oxidase deficient homolog 1	282					cellular copper ion homeostasis|copper ion transport|generation of precursor metabolites and energy|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0						TTTCTCCCTTCCTCTTGTTCT	0.438000													46	74					0	0	0	0
MKNK2	2872	broad.mit.edu	37	19	2041985	2041985	+	Missense_Mutation	SNP	C	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:2041985C>G	uc002lus.2	-	11	1044	c.799G>C	c.(799-801)GAG>CAG	p.E267Q	MKNK2_uc002luq.1_Missense_Mutation_p.E11Q|MKNK2_uc010xgu.1_Missense_Mutation_p.E106Q|MKNK2_uc010xgv.1_Missense_Mutation_p.E136Q|MKNK2_uc002lur.2_Missense_Mutation_p.E267Q|MKNK2_uc002lut.1_Missense_Mutation_p.E11Q	NM_199054	NP_951009	Q9HBH9	MKNK2_HUMAN	MAP kinase-interacting serine/threonine kinase 2	267	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(1)|breast(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTAGCCTCCTCGCTGAAGGCC	0.667000													3	8					0	0	0	0
TLE6	79816	broad.mit.edu	37	19	2987759	2987759	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:2987759G>A	uc002lwu.2	+	8	627	c.227G>A	c.(226-228)GGA>GAA	p.G76E	TLE6_uc002lwt.2_Missense_Mutation_p.G199E|TLE6_uc010dtg.2_Missense_Mutation_p.G199E|TLE6_uc002lwv.2_5'UTR	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	76					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGACCCAGGAACAGACCCA	0.607000													7	91					0	0	0	0
CHAF1A	10036	broad.mit.edu	37	19	4418037	4418037	+	Silent	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:4418037A>G	uc002mal.2	+	4	1081	c.981A>G	c.(979-981)AAA>AAG	p.K327K		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	327	Arg/Glu/Lys-rich.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AATTCGTCAAAGGCTCTACAG	0.353000								Chromatin_Structure					7	97					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606460	21606460	+	Silent	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:21606460C>T	uc002npx.2	+	2	895	c.615C>T	c.(613-615)TTC>TTT	p.F205F	ZNF493_uc002npw.2_Silent_p.F333F|ZNF493_uc002npy.2_Silent_p.F205F	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	205	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTAGTATTTTCTCAACCCCTA	0.348000													4	90					0	0	0	0
CHST8	64377	broad.mit.edu	37	19	34263477	34263477	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:34263477G>A	uc002nus.3	+	5	1289	c.784G>A	c.(784-786)GAG>AAG	p.E262K	CHST8_uc002nut.3_Missense_Mutation_p.E262K|CHST8_uc002nuu.2_Missense_Mutation_p.E262K	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	262	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CGAGCCCTTCGAGAGGCTGGT	0.617000													7	95					0	0	0	0
LMTK3	114783	broad.mit.edu	37	19	48989041	48989041	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:48989041C>A	uc002pjk.2	-	16	4459	c.4459G>T	c.(4459-4461)GTG>TTG	p.V1487L		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CAATTCTCCACGGGGCCTGAG	0.458000													7	15					0.00307968	0.00333632	1	0
MIR512-1	574458	broad.mit.edu	37	19	54170012	54170012	+	RNA	SNP	T	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:54170012T>A	hsa-mir-512-1|MI0003140	+			c.80T>A			MIR512-2_hsa-mir-512-2|MI0003141_5'Flank																	0						GTCCAATGACTGAGGCGAGCA	0.577000													22	32					0	0	0	0
HADHA	3030	broad.mit.edu	37	2	26415267	26415267	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:26415267T>C	uc002rgy.2	-	18	2042	c.1912A>G	c.(1912-1914)ATC>GTC	p.I638V	HADHA_uc010yks.1_Missense_Mutation_p.I551V	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	638					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCCTGATAGATGTAAAAGCCC	0.428000													15	49					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55573405	55573405	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:55573405C>T	uc002ryv.2	-	10	1789	c.947G>A	c.(946-948)CGA>CAA	p.R316Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.R316Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.R316Q|CCDC88A_uc010ypb.1_Missense_Mutation_p.R218Q	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	316	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TGCTTTCTCTCGAAGTGCATC	0.333000													30	93					0	0	0	0
PLGLA	285189	broad.mit.edu	37	2	107002803	107002803	+	RNA	SNP	G	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:107002803G>T	uc002tdp.2	+	1		c.35G>T				NR_003506				Homo sapiens plasminogen-like A (PLGLA), non-coding RNA.												0						TCACTAAGAAGCAGCTGGGGG	0.488000													44	298					1.00776e-21	1.2477e-21	1	0
MERTK	10461	broad.mit.edu	37	2	112732906	112732906	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:112732906T>C	uc002thk.1	+	7	1123	c.1001T>C	c.(1000-1002)ATT>ACT	p.I334T	MERTK_uc002thl.1_Missense_Mutation_p.I158T	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	334	Fibronectin type-III 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TCAGTCATGATTTTTAACACC	0.473000													54	166					0	0	0	0
MYO7B	4648	broad.mit.edu	37	2	128390861	128390861	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:128390861C>A	uc002top.2	+	39	5409	c.5356C>A	c.(5356-5358)CAG>AAG	p.Q1786K	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1786	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCCCCCGCACCAGGTGGAGGT	0.667000													4	24					0.000602214	0.000669127	1	0
LRP1B	53353	broad.mit.edu	37	2	141457953	141457953	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:141457953T>C	uc002tvj.1	-	41	7637	c.6665A>G	c.(6664-6666)AAG>AGG	p.K2222R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2222	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATGACATTCTTGAAATAACG	0.318000										TSP Lung(27;0.18)			35	143					0	0	0	0
ASNSD1	54529	broad.mit.edu	37	2	190532561	190532561	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:190532561G>A	uc002uqt.2	+	5	1970	c.1536G>A	c.(1534-1536)TCG>TCA	p.S512S		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	512	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GCTTTCAGTCGCATGGGCTGG	0.413000													4	142					0	0	0	0
JAG1	182	broad.mit.edu	37	20	10653370	10653370	+	Silent	SNP	C	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:10653370C>G	uc002wnw.2	-	2	882	c.366G>C	c.(364-366)CTG>CTC	p.L122L		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	122	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						AACTGAAAGGCAGCACGATGC	0.677000									Alagille_Syndrome				9	30					0	0	0	0
XRN2	22803	broad.mit.edu	37	20	21314185	21314186	+	Missense_Mutation	DNP	GA	AT	AT			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:21314185_21314186GA>AT	uc002wsf.1	+	10	957_958	c.862_863GA>AT	c.(862-864)GAT>ATT	p.D288I	XRN2_uc002wsg.1_Missense_Mutation_p.D212I|XRN2_uc010zsk.1_Missense_Mutation_p.D234I	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	288					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						CTTGCAGCATGATGAACTTGCC	0.391000													17	129					0	0	0	0
SUN5	140732	broad.mit.edu	37	20	31587923	31587923	+	Missense_Mutation	SNP	C	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:31587923C>G	uc002wyi.2	-	5	390	c.297G>C	c.(295-297)CAG>CAC	p.Q99H		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	99					spermatogenesis					skin(1)	1						CCATGAGCTTCTGGCACAGCA	0.552000													8	47					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	41101056	41101056	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:41101056G>A	uc002xkg.2	-	8	1484	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Q434*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	434	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCTCGTACTGCTGCTGGTTG	0.627000													50	59					0	0	0	0
MYT1	4661	broad.mit.edu	37	20	62871243	62871243	+	Missense_Mutation	SNP	G	T	T	rs139674530		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:62871243G>T	uc002yii.2	+	22	3588	c.3224G>T	c.(3223-3225)CGC>CTC	p.R1075L	MYT1_uc002yij.2_Missense_Mutation_p.R734L|MYT1_uc002yik.2_Missense_Mutation_p.R41L	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1075				R -> H (in Ref. 5; AAA59897).	cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCAATATCCGCCTTCCGCAC	0.622000													37	114					7.04047e-22	8.80059e-22	1	0
DOPEY2	9980	broad.mit.edu	37	21	37623566	37623566	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr21:37623566G>A	uc002yvg.2	+	22	5184	c.5105G>A	c.(5104-5106)CGT>CAT	p.R1702H	DOPEY2_uc011aeb.1_Missense_Mutation_p.R1651H|DOPEY2_uc002yvh.2_Missense_Mutation_p.R553H	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1702					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						AAAGCCCAGCGTCACAGTAAG	0.423000													13	77					0	0	0	0
PDE9A	5152	broad.mit.edu	37	21	44153465	44153465	+	Splice_Site	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr21:44153465G>A	uc002zbm.2	+	7	561	c.498_splice	c.e7-1	p.R166_splice	PDE9A_uc002zbn.2_Splice_Site_p.R39_splice|PDE9A_uc002zbo.2_Splice_Site_p.R113_splice|PDE9A_uc002zbp.2_Splice_Site|PDE9A_uc002zbq.2_Splice_Site_p.R64_splice|PDE9A_uc002zbs.2_Splice_Site|PDE9A_uc002zbr.2_Splice_Site|PDE9A_uc002zbt.2_Splice_Site_p.R38_splice|PDE9A_uc002zbu.2_Splice_Site_p.R32_splice|PDE9A_uc002zbv.2_Splice_Site_p.R6_splice|PDE9A_uc002zbw.2_Splice_Site|PDE9A_uc002zbx.2_Splice_Site_p.R106_splice|PDE9A_uc002zby.2_Splice_Site|PDE9A_uc002zbz.2_Splice_Site_p.R58_splice|PDE9A_uc002zca.2_Splice_Site_p.R125_splice|PDE9A_uc002zcb.2_Splice_Site_p.R140_splice|PDE9A_uc002zcc.2_Splice_Site_p.R65_splice|PDE9A_uc002zcd.2_Splice_Site_p.R80_splice|PDE9A_uc002zce.2_Splice_Site_p.R99_splice|PDE9A_uc002zcf.2_Splice_Site|PDE9A_uc002zcg.2_Splice_Site|PDE9A_uc002zch.2_Splice_Site	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a						platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						TTCATTCCTAGAGCATTCAAA	0.318000													13	36					0	0	0	0
NF2	4771	broad.mit.edu	37	22	30057252	30057252	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr22:30057252A>G	uc003age.3	+	8	1177	c.734A>G	c.(733-735)GAC>GGC	p.D245G	NF2_uc003afy.3_Missense_Mutation_p.D245G|NF2_uc003afz.3_Missense_Mutation_p.D162G|NF2_uc003agf.3_Missense_Mutation_p.D245G|NF2_uc003agb.3_Missense_Mutation_p.D168G|NF2_uc003agc.3_Missense_Mutation_p.D207G|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.D245G|NF2_uc003aga.3_Missense_Mutation_p.D203G|NF2_uc003agh.3_Missense_Mutation_p.D204G|NF2_uc003agi.3_Missense_Mutation_p.D162G|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.D207G	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	245	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.D245fs*31(1)|p.N226_E270del(1)|p.L140_P252del(1)|p.?(1)|p.L127_D382del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CACATTTATGACCCTGAGAAC	0.498000			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				3	157					0	0	0	0
PTPN23	25930	broad.mit.edu	37	3	47450918	47450918	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:47450918G>A	uc003crf.1	+	18	1905	c.1809G>A	c.(1807-1809)GAG>GAA	p.E603E	PTPN23_uc011baw.1_Silent_p.E568E|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.E473E	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	603	Potential.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGTTGTTCGAGGAGCAGCTGA	0.622000													3	39					0	0	0	0
Unknown	0	broad.mit.edu	37	3	95374105	95374105	+	RNA	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:95374105G>A	uc003dro.1	-	5		c.1757C>T								Homo sapiens cDNA FLJ34909 fis, clone NT2RI2009301, moderately similar to BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR.																		AATTCGTGCAGCGGATGTTAC	0.388000													12	31					0	0	0	0
OR5H1	26341	broad.mit.edu	37	3	97852161	97852161	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:97852161A>G	uc011bgt.1	+	1	620	c.620A>G	c.(619-621)CAG>CGG	p.Q207R		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGTTCAATTCAGGTATTCAGC	0.318000													3	83					0	0	0	0
TRH	7200	broad.mit.edu	37	3	129695840	129695840	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:129695840G>A	uc003enc.2	+	3	1071	c.510G>A	c.(508-510)GAG>GAA	p.E170E		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	170					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						Gggaagaagaggaggaggagg	0.547000													3	78					0	0	0	0
NCK1	4690	broad.mit.edu	37	3	136665013	136665013	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:136665013C>T	uc003erh.2	+	3	922	c.815C>T	c.(814-816)TCA>TTA	p.S272L	NCK1_uc011bme.1_Missense_Mutation_p.S208L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	272					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						ATTAGGCCTTCACTCACTGGA	0.413000													28	161					0	0	0	0
PACRGL	133015	broad.mit.edu	37	4	20706289	20706289	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:20706289A>G	uc010iek.2	+	3	450	c.59A>G	c.(58-60)TAT>TGT	p.Y20C	PACRGL_uc003gpu.2_RNA|PACRGL_uc010iei.1_Missense_Mutation_p.Y68C|PACRGL_uc003gpz.2_Missense_Mutation_p.Y20C|PACRGL_uc011bxm.1_Missense_Mutation_p.Y20C|PACRGL_uc003gqa.2_Missense_Mutation_p.Y20C|PACRGL_uc003gpx.3_RNA|PACRGL_uc003gpv.2_Missense_Mutation_p.Y20C|PACRGL_uc003gpw.2_RNA|PACRGL_uc010iej.1_RNA|PACRGL_uc011bxn.1_Missense_Mutation_p.Y20C|PACRGL_uc003gpy.2_Missense_Mutation_p.Y20C	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1	20							binding				0						CCAGGTAACTATGATCAAAGG	0.403000													12	40					0	0	0	0
GNRHR	2798	broad.mit.edu	37	4	68606303	68606303	+	Silent	SNP	A	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:68606303A>T	uc003hdn.2	-	3	2633	c.882T>A	c.(880-882)CCT>CCA	p.P294P	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_3'UTR|uc003hdo.1_5'Flank	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	294	Helical; Name=6; (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	TTAACATTTCAGGATCAAACC	0.393000													4	259					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115997541	115997541	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:115997541C>T	uc003ibu.2	-	2	1331	c.652G>A	c.(652-654)GAA>AAA	p.E218K	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	218	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTCCAGTCTTCCCCAGGAAGA	0.408000													19	62					0	0	0	0
TBC1D9	23158	broad.mit.edu	37	4	141591978	141591978	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:141591978T>C	uc010ioj.2	-	7	1434	c.1162A>G	c.(1162-1164)AGA>GGA	p.R388G		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	388						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AGAAAGTCTCTATCTTTCAAG	0.443000													49	117					0	0	0	0
C4orf41	60684	broad.mit.edu	37	4	184596347	184596347	+	Missense_Mutation	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:184596347G>A	uc003ivx.2	+	7	867	c.691G>A	c.(691-693)GCT>ACT	p.A231T	C4orf41_uc003ivw.2_Missense_Mutation_p.A231T|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	231											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		GTTCAAAATAGCTTTCTTCAG	0.239000													5	40					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26915954	26915954	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:26915954T>C	uc003jgs.1	-	3	476	c.307A>G	c.(307-309)ATA>GTA	p.I103V	CDH9_uc010iug.2_Missense_Mutation_p.I103V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	103	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTTCATCTATAACAAATAGA	0.378000													95	152					0	0	0	0
CDH6	1004	broad.mit.edu	37	5	31302316	31302316	+	Missense_Mutation	SNP	G	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:31302316G>C	uc003jhe.1	+	6	1236	c.910G>C	c.(910-912)GAG>CAG	p.E304Q	CDH6_uc003jhd.1_Missense_Mutation_p.E304Q	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	304	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGCTGAAATTGAGTACAGCAT	0.473000													11	105					0	0	0	0
GHR	2690	broad.mit.edu	37	5	42718796	42718796	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:42718796A>G	uc003jmt.2	+	10	1230	c.1187A>G	c.(1186-1188)GAG>GGG	p.E396G	GHR_uc011cpq.1_Missense_Mutation_p.E209G	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	396	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GACATTCTGGAGACTGATTTC	0.478000													23	96					0	0	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54662572	54662572	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:54662572A>G	uc003jpy.3	+	16	1945	c.1679A>G	c.(1678-1680)AAT>AGT	p.N560S	SKIV2L2_uc011cqi.1_Missense_Mutation_p.N459S	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	560	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				GATCCTCTAAATAGTGCTTTC	0.338000													31	63					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79032587	79032587	+	Missense_Mutation	SNP	C	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:79032587C>G	uc003kgc.2	+	2	8071	c.7999C>G	c.(7999-8001)CCA>GCA	p.P2667A		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2667						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGAGATATGCCAGATCACAG	0.403000													10	46					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202875	140202875	+	Silent	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140202875T>C	uc003lhl.2	+	1	1515	c.1515T>C	c.(1513-1515)AGT>AGC	p.S505S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.S505S|PCDHA5_uc003lhj.1_Silent_p.S505S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	505	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGTCGAGTTACGTTTCGG	0.682000													25	86					0	0	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588971	140588971	+	Silent	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140588971C>A	uc003liz.2	+	1	681	c.492C>A	c.(490-492)ATC>ATA	p.I164I	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	164	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGTAGGAATCAATGCTGTAA	0.388000													11	64					0.000673444	0.00074193	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755399	140755399	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140755399G>A	uc003ljy.1	+	1	1749	c.1749G>A	c.(1747-1749)GAG>GAA	p.E583E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.E583E	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	583	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCCGCAGAGCCCGGCTACC	0.657000													53	143					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169506012	169506012	+	Silent	SNP	G	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:169506012G>A	uc003maf.2	+	49	5108	c.5028G>A	c.(5026-5028)CCG>CCA	p.P1676P	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.P1168P|DOCK2_uc003mah.2_Silent_p.P232P	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1676					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAAGACGCCGAGAGTGGAGC	0.547000													16	141					0	0	0	0
BAT2	7916	broad.mit.edu	37	6	31605291	31605291	+	Silent	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:31605291A>G	uc003nvb.3	+	31	6651	c.6402A>G	c.(6400-6402)GAA>GAG	p.E2134E	BAT2_uc003nvc.3_Silent_p.E2134E	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	2134						cytoplasm|nucleus	protein binding				0						CACCTCGAGAAGGGCCCTCCC	0.677000													28	100					0	0	0	0
TREML2	79865	broad.mit.edu	37	6	41166046	41166046	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:41166046C>A	uc010jxm.1	-	2	356	c.177G>T	c.(175-177)AGG>AGT	p.R59S		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	59	Ig-like V-type.|Extracellular (Potential).			R -> K (in Ref. 3; BAB14668).	T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACTTCTTCTTCCTGATTTTGC	0.552000													47	148					6.31075e-24	7.96503e-24	1	0
OGFRL1	79627	broad.mit.edu	37	6	72003291	72003291	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:72003291A>G	uc003pfx.1	+	3	540	c.377A>G	c.(376-378)AAT>AGT	p.N126S		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	126						membrane	receptor activity				0						TTTTATAAGAATAAAATTCCA	0.299000													8	40					0	0	0	0
EEF1A1	1915	broad.mit.edu	37	6	74229664	74229664	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:74229664T>C	uc003phi.2	-	1	123	c.86A>G	c.(85-87)TAT>TGT	p.Y29C	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phf.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phg.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phk.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phl.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	29						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACCGCATTTATAGATCAGATG	0.418000													15	81					0	0	0	0
MED23	9439	broad.mit.edu	37	6	131926435	131926435	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:131926435T>C	uc003qcs.1	-	14	1732	c.1558A>G	c.(1558-1560)ATT>GTT	p.I520V	MED23_uc003qcq.2_Missense_Mutation_p.I526V|MED23_uc011eca.1_Missense_Mutation_p.I161V|MED23_uc003qct.1_Missense_Mutation_p.I526V|MED23_uc011ecb.1_Intron	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	520					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AAGGGGGTAATAGATCCTGAA	0.393000													10	47					0	0	0	0
SBDS	51119	broad.mit.edu	37	7	66453484	66453484	+	Silent	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:66453484T>C	uc003tvm.1	-	5	811	c.627A>G	c.(625-627)GTA>GTG	p.V209V		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	209					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						CAATCAGACATACCTGAAACA	0.408000			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				12	47					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94037520	94037520	+	Missense_Mutation	SNP	G	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:94037520G>T	uc003ung.1	+	14	1136	c.665G>T	c.(664-666)AGA>ATA	p.R222I	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	222					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCTGGTGAGAGAGGACGTGTT	0.408000										HNSCC(75;0.22)			6	76					8.12818e-05	9.18838e-05	1	0
FBXO24	26261	broad.mit.edu	37	7	100198322	100198322	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:100198322A>G	uc003uvm.1	+	10	1836	c.1543A>G	c.(1543-1545)ATG>GTG	p.M515V	FBXO24_uc003uvn.1_Missense_Mutation_p.M153V|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.M553V|FBXO24_uc011kka.1_Missense_Mutation_p.M503V|PCOLCE_uc011kkb.1_5'Flank|PCOLCE_uc003uvo.2_5'Flank|PCOLCE_uc010lhb.1_5'Flank	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	515						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGGGGGGATGGCCCAGGC	0.662000													3	56					0	0	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117450836	117450836	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:117450836C>T	uc003vjf.2	-	3	489	c.397G>A	c.(397-399)GAG>AAG	p.E133K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	133	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTCTGCTCTCAGCAGCAGCC	0.483000													39	266					0	0	0	0
AKR1B10	57016	broad.mit.edu	37	7	134221441	134221441	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:134221441C>A	uc003vrr.2	+	5	789	c.469C>A	c.(469-471)CTT>ATT	p.L157I		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	157					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						GGTGAAAGCCCTTGGGGTCTC	0.488000													36	148					5.71845e-15	7.01319e-15	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146829576	146829576	+	Missense_Mutation	SNP	G	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:146829576G>T	uc003weu.1	+	8	1839	c.1323G>T	c.(1321-1323)AAG>AAT	p.K441N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	441	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CACAGACCAAGATGAGCCAAA	0.413000										HNSCC(39;0.1)			22	48					1.22574e-08	1.42273e-08	1	0
RUNX1T1	862	broad.mit.edu	37	8	93017495	93017496	+	Missense_Mutation	DNP	GG	CA	CA			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:93017495_93017496GG>CA	uc003yfd.2	-	5	672_673	c.588_589CC>TG	c.(586-591)CTCCTC>CTTGTC	p.L197V	RUNX1T1_uc003yfc.1_Missense_Mutation_p.L170V|RUNX1T1_uc003yfe.1_Missense_Mutation_p.L160V|RUNX1T1_uc010mao.2_Missense_Mutation_p.L170V|RUNX1T1_uc011lgi.1_Missense_Mutation_p.L208V|RUNX1T1_uc003yfb.1_Missense_Mutation_p.L160V|RUNX1T1_uc003yff.1_Missense_Mutation_p.L160V	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	197	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.L159L(1)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCGCAGTGGAGGAGCTCACGCT	0.554000													6	71					0	0	0	0
TTC35	9694	broad.mit.edu	37	8	109462150	109462150	+	Missense_Mutation	SNP	A	G	G			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:109462150A>G	uc003ymw.1	+	2	174	c.139A>G	c.(139-141)AAG>GAG	p.K47E		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	47						endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			ATATGCTTCTAAGCTGGGAGA	0.318000													26	171					0	0	0	0
MTBP	27085	broad.mit.edu	37	8	121468867	121468867	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:121468867C>T	uc003ypc.1	+	7	749	c.704C>T	c.(703-705)TCA>TTA	p.S235L	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	235					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GTTATTGACTCAAAGGAATTA	0.313000													24	282					0	0	0	0
DMRT2	10655	broad.mit.edu	37	9	1057243	1057243	+	Silent	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:1057243T>C	uc003zha.2	+	4	1856	c.1656T>C	c.(1654-1656)CCT>CCC	p.P552P	DMRT2_uc003zgx.3_Silent_p.P319P|DMRT2_uc010mgz.2_Silent_p.P319P|DMRT2_uc003zgy.3_Silent_p.P396P|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Silent_p.P552P	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	552					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TTAAGAGGCCTTCATCTGCCA	0.393000													20	54					0	0	0	0
RC3H2	54542	broad.mit.edu	37	9	125618124	125618124	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:125618124C>T	uc010mwc.1	-	14	2729	c.2488G>A	c.(2488-2490)GAA>AAA	p.E830K	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.E830K|RC3H2_uc004bne.3_Missense_Mutation_p.E830K	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	830						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						AGATGATCTTCTTCAAATTTT	0.343000													9	59					0	0	0	0
RC3H2	54542	broad.mit.edu	37	9	125621230	125621230	+	Missense_Mutation	SNP	C	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:125621230C>T	uc010mwc.1	-	12	2242	c.2001G>A	c.(1999-2001)ATG>ATA	p.M667I	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.M667I|RC3H2_uc004bne.3_Missense_Mutation_p.M667I	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	667	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						GAGAAGAATTCATTCGATCTC	0.522000													5	213					0	0	0	0
TTF1	7270	broad.mit.edu	37	9	135276927	135276927	+	Missense_Mutation	SNP	T	C	C			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:135276927T>C	uc004cbl.2	-	2	1334	c.1282A>G	c.(1282-1284)ATG>GTG	p.M428V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	428					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TCTTCCATCATGGCGCCATCA	0.507000													66	78					0	0	0	0
BMX	660	broad.mit.edu	37	X	15567988	15567988	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:15567988C>A	uc004cww.2	+	18	2009	c.1821C>A	c.(1819-1821)AGC>AGA	p.S607R	BMX_uc004cwx.3_Missense_Mutation_p.S607R|BMX_uc004cwy.3_Missense_Mutation_p.S607R	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	607	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGGTGTTCAGCCTGGGGAAGC	0.552000													4	197					0.00116845	0.00127645	1	0
FGD1	2245	broad.mit.edu	37	X	54496604	54496604	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:54496604C>A	uc004dtg.2	-	4	1680	c.946G>T	c.(946-948)GCC>TCC	p.A316S	FGD1_uc011moi.1_Missense_Mutation_p.A74S	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	316	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CTAGCCAGGGCAGGGGGCCCA	0.557000													11	19					4.68919e-08	5.39464e-08	1	0
DIAPH2	1730	broad.mit.edu	37	X	96213115	96213115	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:96213115G>T	uc004efu.3	+	16	2299	c.1903G>T	c.(1903-1905)GAA>TAA	p.E635*	DIAPH2_uc004eft.3_Nonsense_Mutation_p.E635*	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	635	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GTATAAACCTGAAGTGTCCAT	0.398000													20	112					1.96292e-10	2.29892e-10	1	0
IL1RAPL2	26280	broad.mit.edu	37	X	104728331	104728332	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:104728331_104728332CC>AA	uc004elz.1	+	6	1480_1481	c.724_725CC>AA	c.(724-726)CCA>AAA	p.P242K		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	242	Ig-like C2-type 3.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GCCTCCCAAGCCATTGTTCCCC	0.396000													21	102					0	0	0	0
GLUD2	2747	broad.mit.edu	37	X	120182678	120182678	+	Silent	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:120182678C>A	uc004eto.2	+	1	1217	c.1140C>A	c.(1138-1140)ATC>ATA	p.I380I		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	380					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACATACTGATCCCAGCTGCCA	0.507000													64	220					7.05995e-25	8.99798e-25	1	0
STAG2	10735	broad.mit.edu	37	X	123200245	123200245	+	Missense_Mutation	SNP	C	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:123200245C>A	uc004etz.3	+	22	2563	c.2224C>A	c.(2224-2226)CTT>ATT	p.L742I	STAG2_uc004eua.2_Missense_Mutation_p.L742I|STAG2_uc004eub.2_Missense_Mutation_p.L742I|STAG2_uc004euc.2_Missense_Mutation_p.L742I|STAG2_uc004eud.2_Missense_Mutation_p.L742I|STAG2_uc004eue.2_Missense_Mutation_p.L742I	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	742					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTATGTAATCCTTTGGCAACT	0.328000													13	110					1.5739e-10	1.86006e-10	1	0
HCFC1	3054	broad.mit.edu	37	X	153223611	153223611	+	Silent	SNP	A	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:153223611A>T	uc004fjp.2	-	11	2421	c.1893T>A	c.(1891-1893)CCT>CCA	p.P631P		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	631	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGATGATAGGGCGGGTAG	0.622000													18	67					0	0	0	0
CYP4A22	284541	broad.mit.edu	37	1	47609524	47609535	+	In_Frame_Del	DEL	CTACAGCCTGAC	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:47609524_47609535delCTACAGCCTGAC	uc001cqv.1	+	6	777_788	c.726_737delCTACAGCCTGAC	c.(724-738)ATCTACAGCCTGACC>ATC	p.YSLT243del	CYP4A22_uc009vyo.2_In_Frame_Del_p.YSLT243del|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	243_246						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ATGACACCATCTACAGCCTGACCTCTGCTGGC	0.542													---	---	---							
NOTCH2	4853	broad.mit.edu	37	1	120502074	120502074	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:120502074delT	uc001eik.2	-	12	2223	c.1967delA	c.(1966-1968)CATfs	p.H656fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.H656fs|NOTCH2_uc001eim.3_Frame_Shift_Del_p.H573fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	656	Extracellular (Potential).|EGF-like 17; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGATTCCATGGATACAAGG	0.428			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---							
Unknown	0	broad.mit.edu	37	10	42385707	42385722	+	IGR	DEL	AATGGAATCATCATTA	-	-	rs33914712		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr10:42385707_42385722delAATGGAATCATCATTA								None (None upstream) : LOC441666 (441593 downstream)																							aatggaatcgaatggaatcatcattaaatggaatca	0.042													---	---	---							
OR56A1	120796	broad.mit.edu	37	11	6048343	6048344	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:6048343_6048344insA	uc010qzw.1	-	1	591_592	c.591_592insT	c.(589-594)GATAATfs	p.D197fs		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	197_198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGGTGAAATTATCACAGGAGA	0.460													---	---	---							
LOC494141	494141	broad.mit.edu	37	11	18231789	18231789	+	RNA	DEL	T	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:18231789delT	uc009yhh.2	+	2		c.813delT			LOC494141_uc001mnx.3_RNA|LOC494141_uc009yhi.1_RNA	NR_026541				Homo sapiens cDNA FLJ29025 fis, clone PRS03236.												0						CAGCAATGTCTTTTTTTTTTC	0.433													---	---	---							
Unknown	0	broad.mit.edu	37	11	55890920	55890920	+	IGR	DEL	C	-	-	rs145330583		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:55890920delC								OR8H3 (133 upstream) : OR8J3 (13329 downstream)																							CTTTGCTTGACTAAACATGAT	0.289													---	---	---							
Unknown	0	broad.mit.edu	37	13	79335842	79335842	+	IGR	DEL	C	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr13:79335842delC								RNF219 (101142 upstream) : RBM26 (558258 downstream)																							AACAAACAAACAAAAAAAAAC	0.328													---	---	---							
MAP2K4	6416	broad.mit.edu	37	17	12016562	12016575	+	Frame_Shift_Del	DEL	CCAATATTCTTCTG	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:12016562_12016575delCCAATATTCTTCTG	uc002gnj.2	+	7	767_780	c.698_711delCCAATATTCTTCTG	c.(697-711)TCCAATATTCTTCTGfs	p.S233fs	MAP2K4_uc002gnk.2_Frame_Shift_Del_p.S244fs|MAP2K4_uc010vvi.1_Frame_Shift_Del_p.S115fs|MAP2K4_uc010vvj.1_Frame_Shift_Del_p.S105fs	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	233_237	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.N234I(1)|p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		ATCAAACCTTCCAATATTCTTCTGGACAGAAGTG	0.388			D|Mis|N		pancreatic|breast|colorectal								---	---	---							
ZNF433	163059	broad.mit.edu	37	19	12126445	12126446	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:12126445_12126446insA	uc002msy.1	-	4	1407_1408	c.1236_1237insT	c.(1234-1239)CATGAAfs	p.H412fs	uc002msx.1_Intron|ZNF433_uc002msz.1_Frame_Shift_Ins_p.H377fs	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	412_413	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGTTCTTTCATGATATCGGA	0.431													---	---	---							
TCF7	6932	broad.mit.edu	37	5	133477960	133477961	+	Frame_Shift_Ins	INS	-	GG	GG			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:133477960_133477961insGG	uc003kyt.2	+	6	916_917	c.720_721insGG	c.(718-723)TCAGGGfs	p.S240fs	TCF7_uc003kyu.1_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyv.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyw.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyx.2_Frame_Shift_Ins_p.S38fs|TCF7_uc003kyy.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyz.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kza.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kzb.2_Frame_Shift_Ins_p.S54fs|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	240_241					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCCCCCCTCAGGGAAGCAGGA	0.604													---	---	---							
BAT3	7917	broad.mit.edu	37	6	31610753	31610754	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:31610753_31610754insA	uc003nvg.3	-	14	2119_2120	c.1805_1806insT	c.(1804-1806)ATGfs	p.M602fs	BAT3_uc003nvf.3_Frame_Shift_Ins_p.M596fs|BAT3_uc003nvh.3_Frame_Shift_Ins_p.M596fs|BAT3_uc003nvi.3_Frame_Shift_Ins_p.M596fs|BAT3_uc011dnw.1_Frame_Shift_Ins_p.M596fs|BAT3_uc011dnx.1_Intron	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	602	3.|4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						GAAGATCAGCCATGGAGGGTTG	0.653													---	---	---							
Unknown	0	broad.mit.edu	37	7	15741002	15741003	+	IGR	INS	-	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:15741002_15741003insT								MEOX2 (14694 upstream) : ISPD (386149 downstream)																							cttttcttttcttttttttGAA	0.252													---	---	---							
GNB2	2783	broad.mit.edu	37	7	100276221	100276224	+	Frame_Shift_Del	DEL	GAAG	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:100276221_100276224delGAAG	uc003uwb.2	+	9	1173_1176	c.900_903delGAAG	c.(898-903)ATGAAGfs	p.M300fs	GNB2_uc003uwc.2_Frame_Shift_Del_p.M256fs|GNB2_uc010lhd.2_Frame_Shift_Del_p.M256fs|GNB2_uc010lhe.2_Frame_Shift_Del_p.M256fs|GNB2_uc003uwd.2_Frame_Shift_Del_p.M200fs|GNB2_uc010lhf.2_Frame_Shift_Del_p.M200fs|GNB2_uc003uwe.2_Frame_Shift_Del_p.M300fs|GNB2_uc003uwf.2_Frame_Shift_Del_p.M200fs	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	300_301					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				GGGATGCCATGAAGGGCGACCGTG	0.608													---	---	---							
PAXIP1	22976	broad.mit.edu	37	7	154738224	154738225	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:154738224_154738225insT	uc003wlp.2	-	19	3173_3174	c.3130_3131insA	c.(3130-3132)ATAfs	p.I1044fs	LOC100132707_uc011kvr.1_Intron|LOC100132707_uc003wlo.2_Intron|PAXIP1_uc003wlq.1_Frame_Shift_Ins_p.I1010fs|PAXIP1_uc011kvs.1_Frame_Shift_Ins_p.I1008fs	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1044	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		AAACGTACCTATGCCTCTGGCA	0.406													---	---	---							
Unknown	0	broad.mit.edu	37	X	53795433	53795434	+	IGR	INS	-	T	T			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:53795433_53795434insT								HUWE1 (81760 upstream) : PHF8 (167680 downstream)																							TAGATTTTTTGTTTTTTTTTTC	0.193													---	---	---							
ATP11C	286410	broad.mit.edu	37	X	138820082	138820084	+	In_Frame_Del	DEL	CTT	-	-			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:138820082_138820084delCTT	uc004faz.2	-	28	3387_3389	c.3288_3290delAAG	c.(3286-3291)AGAAGT>AGT	p.R1096del	ATP11C_uc004fax.2_In_Frame_Del_p.R304del|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_In_Frame_Del_p.R1096del	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	1096	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TACCCTGGCACTTCTTCTTCTTA	0.355													---	---	---							
