Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PDZK1	5174	broad.mit.edu	37	1	145931852	145931852	+	Missense_Mutation	SNP	A	C	C			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:145931852A>C	uc010ozf.2	-	1	385	c.361T>G	c.(361-363)Tac>Gac	p.Y121D	PDZK1_uc001eov.1_Non-coding_Transcript	NM_001201326	NP_001188255	Q5T2W1	NHRF3_HUMAN	Homo sapiens PDZ domain containing 1 (PDZK1), transcript variant 3, mRNA.	328					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ACCAGTCTGTACATGTTGTCC	0.438000														83			6		0	0	1	0	0
RGN	9104	broad.mit.edu	37	X	46949254	46949254	+	Silent	SNP	C	T	T			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chrX:46949254C>T	uc004dgz.1	+	4	1395	c.426C>T	c.(424-426)caC>caT	p.H142H	RGN_uc004dha.1_Silent_p.H142H|RGN_uc010nho.1_Silent_p.H89H|RGN_uc010nhp.1_Intron	NM_152869	NP_690608	Q15493	RGN_HUMAN	Homo sapiens regucalcin (senescence marker protein-30) (RGN), transcript variant 2, mRNA.	142					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	9						CTGATCACCACGTGAAAAAGT	0.498000														66			4		0	0	1	0	0
IL6	3569	broad.mit.edu	37	7	22769233	22769233	+	Missense_Mutation	SNP	C	A	A			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr7:22769233C>A	uc003svj.4	+	3	541	c.425C>A	c.(424-426)gCt>gAt	p.A142D	LOC541472_uc010kun.2_5'Flank|IL6_uc011jyo.1_Missense_Mutation_p.A142D|IL6_uc011jyp.1_Missense_Mutation_p.A66D|IL6_uc011jyq.1_Missense_Mutation_p.A196D	NM_000600	NP_000591	P05231	IL6_HUMAN	Homo sapiens interleukin 6 (interferon, beta 2) (IL6), mRNA.	142					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of B cell activation|positive regulation of T cell proliferation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	CAAGCCAGAGCTGTGCAGATG	0.478000														108			5		1.23904e-05	1.23904e-05	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145360624	145360624	+	Silent	SNP	G	A	A			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:145360624G>A	uc021oul.1	+	73	9284	c.9249G>A	c.(9247-9249)tcG>tcA	p.S3083S	NBPF10_uc010oye.2_Intron|NBPF10_uc010oyi.2_Intron|NBPF10_uc010oyj.2_Intron|NBPF10_uc010oyl.2_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc021ouq.1_Non-coding_Transcript	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	3083								p.S3083S(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGTTATTCGACTCCTTCAG	0.478000														14			3		0	0	1	0	0
ZNF66	0	broad.mit.edu	37	19	20959141	20959141	+	RNA	SNP	C	G	G	rs6511160	by1000genomes	TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr19:20959141C>G	uc002npe.3	+	0		c.32C>G								Homo sapiens zinc finger protein 66, mRNA (cDNA clone MGC:87430 IMAGE:5270688), complete cds.																		TCCAGGTCGTCTGTTCACTGC	0.592000														105			7		0	0	1	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2582	2582	+	RNA	SNP	C	T	T			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chrGL000237.1:2582C>T	uc011mgu.1	-	0		c.105G>A								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		cagagcgagacgagccacggt	0.607000														28			3		0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33954144	33954144	+	Missense_Mutation	SNP	A	G	G			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:33954144A>G	uc001bxj.4	+	2	664	c.497A>G	c.(496-498)gAt>gGt	p.D166G	ZSCAN20_uc001bxk.2_Missense_Mutation_p.D166G|ZSCAN20_uc009vui.3_Missense_Mutation_p.D166G	NM_145238	NP_660281	P17040	ZSC20_HUMAN	Homo sapiens zinc finger and SCAN domain containing 20 (ZSCAN20), mRNA.	166					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CAGCCAGTGGATCCCTGGCCT	0.517000														112			5		0	0	1	0	0
DDX11L11	0	broad.mit.edu	37	12	92018	92018	+	Missense_Mutation	SNP	T	C	C			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr12:92018T>C	uc010sdi.1	-	1	320	c.292A>G	c.(292-294)Agt>Ggt	p.S98G	DDX11L11_uc010sdj.1_Non-coding_Transcript					SubName: Full=DEAD/H box polypeptide 11 like 11;																		GACTCCACACTCTCCTGGGTT	0.592000														20			3		0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	C	C	rs141357429	by1000genomes	TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr17:39274087G>C	uc002hvz.3	-	0	520	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(2)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000														46			4		0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65667687	65667687	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr15:65667687C>T	uc002aos.2	-	1	409	c.157G>A	c.(157-159)Gcc>Acc	p.A53T		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	Homo sapiens immunoglobulin superfamily, DCC subclass, member 3 (IGDCC3), mRNA.	53	Ig-like C2-type 1.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCGGGGACGGCAACATCATCA	0.567000														61			4		0	0	1	0	0
PLK1S1	55857	broad.mit.edu	37	20	21143043	21143043	+	Missense_Mutation	SNP	G	A	A			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr20:21143043G>A	uc002wsb.3	+	4	1070	c.937G>A	c.(937-939)Gaa>Aaa	p.E313K	PLK1S1_uc010zsh.2_Missense_Mutation_p.E210K|PLK1S1_uc010zsi.2_Missense_Mutation_p.E180K|PLK1S1_uc010zsj.2_Non-coding_Transcript|BC042893_uc002wsc.3_Intron|PLK1S1_uc002wsd.3_Non-coding_Transcript	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	Homo sapiens polo-like kinase 1 substrate 1 (PLK1S1), transcript variant 1, mRNA.	313					spindle organization	centrosome	protein kinase binding										TGAAGTTGAGGAAAAAAGAGC	0.443000														43			8		0	0	1	0	0
BC107568	0	broad.mit.edu	37	GL000195.1	138103	138103	+	RNA	SNP	T	C	C			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chrGL000195.1:138103T>C	uc003won.1	+	0		c.137T>C								Homo sapiens cDNA clone IMAGE:3683736.																		TGGGGACGCATAGTTAAGGTG	0.597000														15			3		0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139980687	139980687	+	Missense_Mutation	SNP	T	C	C	rs143283803		TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr4:139980687T>C	uc003ihp.1	-	8	1447	c.1196A>G	c.(1195-1197)cAg>cGg	p.Q399R	ELF2_uc003ihm.1_Missense_Mutation_p.Q351R|ELF2_uc003ihn.1_Missense_Mutation_p.Q339R|ELF2_uc003iho.1_Missense_Mutation_p.Q322R|ELF2_uc011chc.1_Missense_Mutation_p.Q214R	NM_201999	NP_973728	Q15723	ELF2_HUMAN	Homo sapiens E74-like factor 2 (ets domain transcription factor) (ELF2), transcript variant 1, mRNA.	411					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					ATTAACTGACTGAACTGCCAC	0.438000														162			6		0	0	1	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr3:195400728A>G	uc003fuw.3	+	8	1218	c.24A>G	c.(22-24)ccA>ccG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_Non-coding_Transcript|SDHAP2_uc003fuv.3_Non-coding_Transcript					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2 (SDHAP2), non-coding RNA.																		GATTGTGCCCAGCCTGTACGC	0.587000														113			7		0	0	1	0	0
abParts	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	G	G	rs1054158		TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr22:22663087A>G	uc021wml.1	+	30		c.2445A>G			abParts_uc011aiq.1_Non-coding_Transcript|abParts_uc011aip.2_Non-coding_Transcript|abParts_uc010gto.3_Non-coding_Transcript					Parts of antibodies, mostly variable regions.																		GCTGCCACATAAGTTGTCCTT	0.303000														53			6		0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16975913	16975918	+	RNA	DEL	CCTGTT	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:16975913_16975918delCCTGTT	uc010och.2	+	10		c.1935_1940delCCTGTT			MST1P2_uc009vox.3_Non-coding_Transcript|MST1P2_uc001azm.4_Non-coding_Transcript					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		GGTTGGGCACCCTGTTCCAGAACCCA	0.578													---	88	---	---	11	---					
SLC16A4	9122	broad.mit.edu	37	1	110906427	110906427	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:110906427delA	uc001dzo.2	-	8	1675	c.1425delT	c.(1423-1425)tttfs	p.F475fs	SLC16A4_uc009wfs.2_Frame_Shift_Del_p.F427fs|SLC16A4_uc001dzp.2_Frame_Shift_Del_p.F307fs|SLC16A4_uc010ovy.2_Frame_Shift_Del_p.F413fs|SLC16A4_uc010ovz.2_Frame_Shift_Del_p.L372fs|SLC16A4_uc001dzq.2_Frame_Shift_Del_p.F245fs	NM_004696	NP_004687	O15374	MOT5_HUMAN	Homo sapiens solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (SLC16A4), transcript variant 1, mRNA.	475						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity	p.F475fs*12(2)		breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(2)|ovary(3)|prostate(1)|stomach(2)	16		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	CCAATGGTACAAAAAAAAAGG	0.388													---	125	---	---	7	---					
KCNN3	3782	broad.mit.edu	37	1	154680586	154680588	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr1:154680586_154680588delGCT	uc021pah.1	-	8	2419_2421	c.2105_2107delAGC	c.(2104-2109)cagctc>ctc	p.Q702del	KCNN3_uc001ffo.3_In_Frame_Del_p.Q382del|KCNN3_uc001ffp.3_In_Frame_Del_p.Q687del	NM_001204087	NP_001191016	Q9UGI6	KCNN3_HUMAN	Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (KCNN3), transcript variant 3, mRNA.	692						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GCAGACAGGAGCTGCTGCTGCTG	0.640													---	394	---	---	7	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr2:96992793_96992795delGAG	uc002svy.3	+	0	859_861	c.448_450delGAG	c.(448-450)gagdel	p.E155del	ITPRIPL1_uc002svx.3_In_Frame_Del_p.E147del|ITPRIPL1_uc010yuk.2_In_Frame_Del_p.E139del|ITPRIPL1_uc010yul.2_In_Frame_Del_p.E139del	NM_178495	NP_001156996	Q6GPH6	IPIL1_HUMAN	Homo sapiens inositol 1,4,5-trisphosphate receptor interacting protein-like 1 (ITPRIPL1), transcript variant 1, mRNA.	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													---	151	---	---	8	---					
TULP1	7287	broad.mit.edu	37	6	35478775	35478777	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr6:35478775_35478777delTCC	uc003okv.4	-	4	372_374	c.360_362delGGA	c.(358-363)gaggaa>gaa	p.120_121EE>E	TULP1_uc003okw.4_In_Frame_Del_p.67_68EE>E|TULP1_uc021yyx.1_In_Frame_Del_p.120_121EE>E|TULP1_uc021yyy.1_In_Frame_Del_p.120_121EE>E	NM_003322	NP_003313	O00294	TULP1_HUMAN	Homo sapiens tubby like protein 1 (TULP1), mRNA.	120	Poly-Glu.		Missing (in RP14).		dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding	p.E119K(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						gtcctcctcttcctcctcctcct	0.567													---	246	---	---	7	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr10:30316501_30316503delCTG	uc009xle.2	-	2	2711_2713	c.2574_2576delCAG	c.(2572-2577)agcagt>agt	p.858_859SS>S	KIAA1462_uc001iux.3_In_Frame_Del_p.858_859SS>S|KIAA1462_uc001iuy.3_Intron|KIAA1462_uc001iuz.3_In_Frame_Del_p.720_721SS>S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	Homo sapiens KIAA1462 (KIAA1462), mRNA.	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													---	221	---	---	8	---					
EMG1	10436	broad.mit.edu	37	12	7080210	7080211	+	Frame_Shift_Ins	INS	-	G	G	rs141646579	by1000genomes	TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr12:7080210_7080211insG	uc001qsh.4	+	0	267_268	c.124_125insG	c.(124-126)agtfs	p.S42fs	PHB2_uc021quf.1_5'Flank|PHB2_uc021qug.1_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_Non-coding_Transcript|EMG1_uc010sfv.1_Non-coding_Transcript	NM_006331	NP_006322	Q92979	NEP1_HUMAN	Homo sapiens EMG1 nucleolar protein homolog (S. cerevisiae) (EMG1), mRNA.	42					ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										CGGAGGCCGTAGTTTATTGTGG	0.569													---	51	---	---	9	---					
SACS	26278	broad.mit.edu	37	13	23914687	23914687	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr13:23914687delT	uc001uon.2	-	9	3917	c.3328delA	c.(3328-3330)attfs	p.I1110fs	SACS_uc001uoo.2_Frame_Shift_Del_p.I963fs|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	Homo sapiens spastic ataxia of Charlevoix-Saguenay (sacsin) (SACS), mRNA.	1110					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|Hsp70 protein binding|chaperone binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGGCTTCAATTTTTTTTGCC	0.383													---	416	---	---	8	---					
ZIC2	7546	broad.mit.edu	37	13	100635008	100635010	+	In_Frame_Del	DEL	CCA	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr13:100635008_100635010delCCA	uc001von.3	+	0	983_985	c.690_692delCCA	c.(688-693)gcccac>gcc	p.H239del		NM_007129	NP_009060	O95409	ZIC2_HUMAN	Homo sapiens Zic family member 2 (ZIC2), mRNA.	239	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).|Poly-His.		H -> HH.|Missing.		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGCCGCGGCccaccaccaccac	0.621													---	143	---	---	8	---					
RBM25	58517	broad.mit.edu	37	14	73572607	73572608	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr14:73572607_73572608delAG	uc010ttu.2	+	11	1471_1472	c.1195_1196delAG	c.(1195-1197)agafs	p.R399fs	RBM25_uc001xno.3_Frame_Shift_Del_p.R399fs|RBM25_uc001xnp.3_Frame_Shift_Del_p.R194fs	NM_021239	NP_067062	P49756	RBM25_HUMAN	Homo sapiens RNA binding motif protein 25 (RBM25), mRNA.	399	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				RNA splicing|apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agagcgggaaagagagagagag	0.446													---	51	---	---	11	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr19:6531149_6531151delGCT	uc002mfh.2	+	0	140_142	c.102_104delGCT	c.(100-105)gggctg>ggg	p.L41del		NM_003811	NP_003802	P41273	TNFL9_HUMAN	Homo sapiens tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9), mRNA.	41	Poly-Leu.				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													---	173	---	---	8	---					
SLC8A2	6543	broad.mit.edu	37	19	47935681	47935683	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr19:47935681_47935683delTCC	uc010ele.3	-	7	2146_2148	c.2130_2132delGGA	c.(2128-2133)gaggac>gac	p.E710del	SLC8A2_uc002pgx.3_In_Frame_Del_p.E710del|SLC8A2_uc010xyq.2_In_Frame_Del_p.E466del|SLC8A2_uc010xyr.2_In_Frame_Del_p.E173del			Q9UPR5	NAC2_HUMAN	Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 2 (SLC8A2), mRNA.	710					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCGGGACCCGTCCTCCTCCTCCT	0.616													---	308	---	---	7	---					
LILRB1	10859	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr19:55146148_55146150delCTC	uc002qgj.3	+	10	1757_1759	c.1417_1419delCTC	c.(1417-1419)ctcdel	p.L479del	LILRB1_uc010erp.1_In_Frame_Del_p.L94del|LILRB1_uc002qgl.3_In_Frame_Del_p.L479del|LILRB1_uc002qgk.3_In_Frame_Del_p.L480del|LILRB1_uc002qgm.3_In_Frame_Del_p.L480del|LILRB1_uc010erq.3_In_Frame_Del_p.L463del|LILRB1_uc010err.3_Non-coding_Transcript	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, mRNA.	479					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.L479del(1)|p.L478L(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.581										HNSCC(37;0.09)			---	157	---	---	8	---					
DDX27	55661	broad.mit.edu	37	20	47858504	47858504	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr20:47858504delA	uc002xuh.3	+	16	2126	c.2065delA	c.(2065-2067)aaafs	p.K689fs		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (DDX27), mRNA.	689						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.K691fs*4(3)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAGGATGCCAAAAAAAAGGG	0.488													---	208	---	---	9	---					
PRDM15	63977	broad.mit.edu	37	21	43221415	43221417	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr21:43221415_43221417delCTG	uc002yzq.1	-	30	4618_4620	c.4507_4509delCAG	c.(4507-4509)cagdel	p.Q1503del	PRDM15_uc002yzo.3_In_Frame_Del_p.Q1174del|PRDM15_uc002yzp.3_In_Frame_Del_p.Q1194del|PRDM15_uc002yzr.1_In_Frame_Del_p.Q1194del	NM_022115	NP_071398	P57071	PRD15_HUMAN	Homo sapiens PR domain containing 15 (PRDM15), transcript variant 1, mRNA.	1503	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						AGCTGTACATCTGCTGCTGCTGC	0.611													---	248	---	---	8	---					
PICK1	9463	broad.mit.edu	37	22	38471034	38471036	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chr22:38471034_38471036delGGA	uc003auq.3	+	12	1533_1535	c.1143_1145delGGA	c.(1141-1146)ggggag>ggg	p.E388del	PICK1_uc003aur.3_In_Frame_Del_p.E388del|PICK1_uc003aus.3_In_Frame_Del_p.E388del|PICK1_uc003aut.3_In_Frame_Del_p.E388del	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	Homo sapiens protein interacting with PRKCA 1 (PICK1), transcript variant 1, mRNA.	388	Poly-Glu.				DNA methylation involved in embryo development|DNA methylation involved in gamete generation|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	Golgi apparatus|cell junction|endocytic vesicle membrane|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					TCACAGATGGggaggaggaggag	0.635													---	77	---	---	8	---					
GAGE2B	645037	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	TAT	TAT			TCGA-HZ-7923-01A-12D-2154-08	TCGA-HZ-7923-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a75a6eb9-4d65-4109-9507-f4ce26beb471	ed657707-e905-4a64-93ba-9139dbb1fb60	g.chrX:49208295_49208296insTAT	uc004dnv.4	+	1	140_141	c.24_25insTAT	c.(22-27)insTAT	p.9_10insY	GAGE2B_uc004dnl.4_Intron|GAGE2B_uc022bwc.1_Intron|GAGE2B_uc011mne.2_Intron|GAGE2B_uc004dnn.4_Intron|GAGE2B_uc011mnf.2_Intron|GAGE2B_uc004dnq.4_Intron|GAGE2B_uc004dnr.4_Intron|GAGE2B_uc004dnk.4_Intron|GAGE2B_uc004dno.4_Intron|GAGE2B_uc004dnp.4_Intron|GAGE2B_uc010njc.3_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnt.4_In_Frame_Ins_p.9_10insY|GAGE2B_uc004dnu.4_In_Frame_Ins_p.9_10insY	NM_001127212	NP_001091881			Homo sapiens G antigen 2A (GAGE2A), mRNA.																		GAAGATCGACCTATCGGCCTAG	0.465													---	64	---	---	7	---					
