Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDHAC2	56134	broad.mit.edu	37	5	140256291	140256291	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr5:140256291G>A	uc003lic.2	+	0	1361	c.1234G>A	c.(1234-1236)Gcc>Acc	p.A412T	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc003lhx.2_Intron|PCDHAC2_uc003lia.2_Intron|PCDHAC2_uc011daf.2_Missense_Mutation_p.A412T	NM_018903	NP_061726	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 12 (PCDHA12), transcript variant 1, mRNA.	426	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACAGCGCCCTGGACCG	0.607000													8	141					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113176133	113176133	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:113176133C>T	uc003eag.4	-	12	1798	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	SPICE1_uc003eaf.4_Non-coding_Transcript|SPICE1_uc003eah.1_Missense_Mutation_p.E399K	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	Homo sapiens spindle and centriole associated protein 1 (SPICE1), mRNA.	503					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GGCAACTCTTCCTGTGGGAAT	0.448000													40	58					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52404725	52404725	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr15:52404725A>T	uc002abq.3	-	0	248	c.199T>A	c.(199-201)Tac>Aac	p.Y67N		NM_020396	NP_065129	Q9HD36	B2L10_HUMAN	Homo sapiens BCL2-like 10 (apoptosis facilitator) (BCL2L10), mRNA.	57					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		TAGCCGAGGTAGGCGGAGAAA	0.716000													11	17					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140800833	140800833	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr5:140800833G>A	uc003lkq.2	+	0	297	c.39G>A	c.(37-39)ctG>ctA	p.L13L	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljq.2_Intron|PCDHGC5_uc003ljs.2_Intron|PCDHGC5_uc003lju.2_Intron|PCDHGC5_uc003ljw.2_Intron|PCDHGC5_uc003ljy.2_Intron|PCDHGC5_uc003lka.2_Intron|PCDHGC5_uc003lkc.2_Intron|PCDHGC5_uc003lkd.2_Intron|PCDHGC5_uc003lkf.2_Intron|PCDHGC5_uc003lkh.2_Intron|PCDHGC5_uc003lkj.2_Intron|PCDHGC5_uc003lkl.2_Intron|PCDHGC5_uc003lkn.2_Intron|PCDHGC5_uc003lko.1_Silent_p.L13L|PCDHGC5_uc003lkp.2_Silent_p.L13L	NM_018914	NP_061737	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant 1, mRNA.	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTCGGCTGCTGCTGCTGC	0.607000													12	22					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123596282	123596282	+	Missense_Mutation	SNP	T	T	C	rs148135505	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr10:123596282T>C	uc001lfp.3	-	9	1290	c.1208A>G	c.(1207-1209)tAt>tGt	p.Y403C	ATE1_uc001lfq.3_Missense_Mutation_p.Y403C|ATE1_uc010qtr.2_Missense_Mutation_p.Y288C|ATE1_uc010qts.2_Missense_Mutation_p.Y307C|ATE1_uc010qtt.2_Missense_Mutation_p.Y396C|ATE1_uc001lfr.3_Missense_Mutation_p.Y104C|ATE1_uc009xzu.3_Non-coding_Transcript	NM_007041	NP_008972	O95260	ATE1_HUMAN	Homo sapiens arginyltransferase 1 (ATE1), transcript variant 2, mRNA.	403					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				CATATAATAATAGCTGAGTTG	0.308000													4	240					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39932148	39932148	+	Silent	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chrX:39932148A>G	uc004den.4	-	3	2743	c.2451T>C	c.(2449-2451)acT>acC	p.T817T	BCOR_uc004dep.4_Silent_p.T817T|BCOR_uc004deo.4_Silent_p.T817T|BCOR_uc004dem.4_Silent_p.T817T|BCOR_uc004deq.4_Silent_p.T817T	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	Homo sapiens BCL6 corepressor (BCOR), transcript variant 5, mRNA.	817					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						CGTTTGTGTCAGTTTTAGCAT	0.547000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						34	32					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90180077	90180077	+	Missense_Mutation	SNP	A	A	G	rs113075842		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:90180077A>G	uc001dnl.4	+	2	2190	c.1948A>G	c.(1948-1950)Acc>Gcc	p.T650A		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member C (LRRC8C), mRNA.	650						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TAACAGCATCACCTACATCCC	0.418000													34	72					0	0	1	0	0
ZIC2	7546	broad.mit.edu	37	13	100635322	100635322	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr13:100635322G>A	uc001von.3	+	0	1297	c.1004G>A	c.(1003-1005)tGc>tAc	p.C335Y		NM_007129	NP_009060	O95409	ZIC2_HUMAN	Homo sapiens Zic family member 2 (ZIC2), mRNA.	335			C -> F (in HPE5).		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCTTCCCCTGCCCCTTCCCG	0.617000													22	55					0	0	1	0	0
TOB1	10140	broad.mit.edu	37	17	48941072	48941072	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr17:48941072T>A	uc002isw.3	-	1	750	c.307A>T	c.(307-309)Att>Ttt	p.I103F	TOB1_uc021uac.1_5'UTR|TOB1_uc010wmz.2_Missense_Mutation_p.I103F|TOB1_uc021uad.1_Missense_Mutation_p.I103F|LOC400604_uc002isy.3_5'Flank	NM_005749	NP_005740	P50616	TOB1_HUMAN	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.	103					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TTTTCACCAATTTGGTAAGAA	0.423000											OREG0024576	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	119					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	623528	623528	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:623528T>C	uc002lpf.1	-	5	1272	c.1216A>G	c.(1216-1218)Atg>Gtg	p.M406V		NM_005035	NP_005026	O00411	RPOM_HUMAN	Homo sapiens polymerase (RNA) mitochondrial (DNA directed) (POLRMT), nuclear gene encoding mitochondrial protein, mRNA.	406					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCTCCATGTGGAGCTGC	0.632000													7	34					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3230734	3230734	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr4:3230734T>C	uc021xkv.1	+	58	8252	c.8107T>C	c.(8107-8109)Tcc>Ccc	p.S2703P		NM_002111	NP_002102	P42858	HD_HUMAN	Homo sapiens huntingtin (HTT), mRNA.	2703					Golgi organization|establishment of mitotic spindle orientation|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	Golgi apparatus|autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGTGGTCAGATCCGTAAGTGA	0.602000													20	32					0	0	1	0	0
DGCR6L	85359	broad.mit.edu	37	22	20302504	20302504	+	Silent	SNP	A	A	G	rs138515918	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr22:20302504A>G	uc010gsc.3	-	3	985	c.868T>C	c.(868-870)Ttg>Ctg	p.L290L	DGCR6L_uc002zrx.3_Intron|DGCR6L_uc010gsb.3_Intron			Q9BY27	DGC6L_HUMAN	Homo sapiens DiGeorge syndrome critical region gene 6-like (DGCR6L), mRNA.	0						nucleus				endometrium(1)|kidney(1)|lung(2)|stomach(1)	5	Colorectal(54;0.0993)					TCTGCCCCCAACAGGGCCACT	0.672000													3	43					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223536686	223536686	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:223536686T>C	uc001hnx.3	-	0	716	c.82A>G	c.(82-84)Aga>Gga	p.R28G	SUSD4_uc001hny.4_Missense_Mutation_p.R28G|SUSD4_uc010puw.2_5'UTR|SUSD4_uc001hnz.2_Missense_Mutation_p.R28G|SUSD4_uc010pux.1_Missense_Mutation_p.R28G	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	Homo sapiens sushi domain containing 4 (SUSD4), transcript variant 1, mRNA.	28						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GCCAAGAGTCTCTGGGGGGAC	0.597000													37	78					0	0	1	0	0
C2orf28	51374	broad.mit.edu	37	2	27436144	27436144	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:27436144A>G	uc002rjf.3	+	1	537	c.364A>G	c.(364-366)Aat>Gat	p.N122D	SLC5A6_uc002rjd.3_5'Flank|SLC5A6_uc010eyv.1_5'Flank|SLC5A6_uc002rje.1_5'Flank|C2orf28_uc002rjg.3_Missense_Mutation_p.N9D	NM_001170795	NP_001164266	Q6UW56	APR3_HUMAN	Homo sapiens chromosome 2 open reading frame 28 (C2orf28), transcript variant 3, mRNA.	67						integral to membrane|plasma membrane				large_intestine(2)|lung(2)|skin(2)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCTGCCTGAATCAGAAGGG	0.468000													20	55					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30492406	30492406	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr7:30492406G>A	uc003tav.3	-	5	1150	c.627C>T	c.(625-627)tcC>tcT	p.S209S	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	Homo sapiens nucleotide-binding oligomerization domain containing 1 (NOD1), mRNA.	209	NACHT.				JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of dendritic cell antigen processing and presentation|protein oligomerization|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						GTAGCAGCATGGACTTGCCCA	0.612000													21	43					0	0	1	0	0
TMEM178	130733	broad.mit.edu	37	2	39934299	39934299	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:39934299G>T	uc002rrt.3	+	2	705	c.625G>T	c.(625-627)Gtg>Ttg	p.V209L	TMEM178_uc021vgg.1_Missense_Mutation_p.V27L|TMEM178_uc010fam.2_Intron	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	Homo sapiens transmembrane protein 178 (TMEM178), transcript variant 1, mRNA.	209						integral to membrane				endometrium(1)|large_intestine(5)|lung(5)	11		all_hematologic(82;0.248)				GACCCAGCACGTGGCTGGACT	0.602000													3	86					6.4e-05	6.74409e-05	1	1	0
LYZ	4069	broad.mit.edu	37	12	69743944	69743944	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr12:69743944G>T	uc001suw.2	+	1	248	c.193G>T	c.(193-195)Gct>Tct	p.A65S		NM_000239	NP_000230	P61626	LYSC_HUMAN	Homo sapiens lysozyme (LYZ), mRNA.	65					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			AAACTACAATGCTGGAGACAG	0.408000													61	126					4.09106e-26	4.77291e-26	1	1	0
ST18	9705	broad.mit.edu	37	8	53077753	53077753	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr8:53077753G>T	uc003xqz.2	-	6	1393	c.1237C>A	c.(1237-1239)Ccc>Acc	p.P413T	ST18_uc011ldq.1_Missense_Mutation_p.P60T|ST18_uc011ldr.1_Missense_Mutation_p.P378T|ST18_uc011lds.1_Missense_Mutation_p.P318T|ST18_uc003xra.2_Missense_Mutation_p.P413T|ST18_uc003xrb.2_Missense_Mutation_p.P413T	NM_014682	NP_055497	O60284	ST18_HUMAN	Homo sapiens suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) (ST18), mRNA.	413						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCCGGCGTGGGACACTTGAGC	0.403000													3	42					1	1	1	1	0
MLL2	8085	broad.mit.edu	37	19	36229181	36229181	+	Splice_Site	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:36229181A>G	uc021usv.1	+	37	7873	c.7873_splice	c.e37-2	p.G2625_splice	MLL2_uc021usu.1_Splice_Site_p.G1439_splice	NM_014727	NP_055542	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4), mRNA.	5447	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						TCATCCCTGCAGGGCATCGGG	0.602000			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)			10	20					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150421548	150421548	+	Silent	SNP	T	T	C	rs146394127	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:150421548T>C	uc003eyg.3	-	0	195	c.138A>G	c.(136-138)gaA>gaG	p.E46E	FAM194A_uc003eyh.3_Intron	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	Homo sapiens family with sequence similarity 194, member A (FAM194A), mRNA.	46	Glu-rich.							p.E46E(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						cctccacctcttcctcctcct	0.607000													3	22					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71036918	71036918	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:71036918G>A	uc002shf.3	-	5	1688	c.1611C>T	c.(1609-1611)tcC>tcT	p.S537S	CLEC4F_uc010yqv.1_Silent_p.S537S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	Homo sapiens C-type lectin domain family 4, member F (CLEC4F), mRNA.	537	C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TCCAGCGCCAGGAGCCCTCTG	0.552000													23	51					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59274493	59274493	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr12:59274493G>A	uc001sqr.3	-	12	1917	c.1671C>T	c.(1669-1671)ggC>ggT	p.G557G	LRIG3_uc009zqh.3_Silent_p.G497G|LRIG3_uc010ssh.2_Non-coding_Transcript	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3), transcript variant 2, mRNA.	557	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CCATCACCTCGCCACCTTGGG	0.483000			T	ROS1	NSCLC								4	135					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610566	10610566	+	Silent	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:10610566G>T	uc002moq.1	-	1	300	c.144C>A	c.(142-144)ggC>ggA	p.G48G	KEAP1_uc002mor.1_Silent_p.G48G	NM_012289	NP_987096	Q14145	KEAP1_HUMAN	Homo sapiens kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2, mRNA.	48					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AGGTGCGGTTGCCATGCTGGG	0.627000													22	33					6.44725e-10	7.17989e-10	1	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125826081	125826081	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:125826081A>C	uc003eim.1	-	20	2546	c.2356T>G	c.(2356-2358)Ttt>Gtt	p.F786V	ALDH1L1_uc010hse.1_Non-coding_Transcript|ALDH1L1_uc011bki.1_Missense_Mutation_p.F685V|ALDH1L1_uc003ein.1_Missense_Mutation_p.F321V	NM_012190	NP_036322	O75891	AL1L1_HUMAN	Homo sapiens aldehyde dehydrogenase 1 family, member L1 (ALDH1L1), mRNA.	786	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GTTGGCTCAAAGAAGAACCCT	0.557000													31	18					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64388953	64388953	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr7:64388953C>G	uc003tto.3	+	3	1323	c.1247C>G	c.(1246-1248)aCt>aGt	p.T416S	ZNF273_uc003ttl.3_Missense_Mutation_p.T351S|ZNF273_uc003ttn.3_Missense_Mutation_p.T351S	NM_021148	NP_066971	Q14593	ZN273_HUMAN	Homo sapiens zinc finger protein 273 (ZNF273), transcript variant 1, mRNA.	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CGGTCCACAACTCTTACTAAA	0.348000													63	82					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4844785	4844785	+	Silent	SNP	G	G	A	rs34558416	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:4844785G>A	uc002mbj.2	-	6	1032	c.855C>T	c.(853-855)ggC>ggT	p.G285G	PLIN3_uc002mbk.2_Silent_p.G273G|PLIN3_uc002mbl.3_Silent_p.G285G	NM_005817	NP_005808	O60664	PLIN3_HUMAN	Homo sapiens perilipin 3 (PLIN3), transcript variant 1, mRNA.	285					vesicle-mediated transport	Golgi apparatus|endosome membrane|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTGATCAACGCCTTGCTTGA	0.597000													15	28					0	0	1	0	0
NFYA	4800	broad.mit.edu	37	6	41059422	41059422	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr6:41059422G>A	uc003opo.3	+	6	881	c.703G>A	c.(703-705)Ggg>Agg	p.G235R	NFYA_uc003opp.3_Missense_Mutation_p.G206R|NFYA_uc003opq.3_Missense_Mutation_p.G206R	NM_002505	NP_002496	P23511	NFYA_HUMAN	Homo sapiens nuclear transcription factor Y, alpha (NFYA), transcript variant 1, mRNA.	235					transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	9	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAATTCAGGAGGGATGGTCAT	0.418000													17	33					0	0	1	0	0
TRIM77P	390231	broad.mit.edu	37	11	89447375	89447375	+	Missense_Mutation	SNP	C	C	T	rs17221124	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr11:89447375C>T	uc010rtw.2	+	2	523	c.523C>T	c.(523-525)Cgg>Tgg	p.R175W		NM_001146162	NP_001139634			Homo sapiens tripartite motif containing 77, pseudogene (TRIM77P), mRNA.																		TATAAATTTGCGGAGCATGAT	0.373000													5	156					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33810281	33810281	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:33810281T>C	uc002rpa.1	-	7	1193	c.1119A>G	c.(1117-1119)ggA>ggG	p.G373G	FAM98A_uc010yne.1_Silent_p.G178G|FAM98A_uc010ynd.1_Silent_p.G204G|FAM98A_uc002roz.1_Silent_p.G211G	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	Homo sapiens family with sequence similarity 98, member A (FAM98A), mRNA.	374	Gly-rich.							p.G372G(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					TTCCTCTTCCTCCCCCTCGGC	0.562000													3	99					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93646100	93646100	+	Silent	SNP	C	C	T	rs6121	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:93646100C>T	uc003drb.4	-	1	569	c.228G>A	c.(226-228)ccG>ccA	p.P76P	PROS1_uc010hoo.3_5'UTR|PROS1_uc003dqz.4_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	Homo sapiens protein S (alpha) (PROS1), mRNA.	76	Gla.		P -> L.		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	Golgi lumen|Golgi membrane|endoplasmic reticulum membrane|extracellular region|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity	p.D75Y(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTACCGTTTCCGGGTCATTTT	0.388000													3	101					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49689059	49689059	+	Silent	SNP	C	C	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:49689059C>A	uc003cxe.4	+	4	2184	c.2070C>A	c.(2068-2070)atC>atA	p.I690I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	Homo sapiens bassoon (presynaptic cytomatrix protein) (BSN), mRNA.	690					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGACGGCATCTCTAGCTCCC	0.602000													26	50					7.16026e-08	7.71105e-08	1	1	0
CAPN5	726	broad.mit.edu	37	11	76823693	76823693	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr11:76823693G>A	uc009yup.3	+	4	661	c.476G>A	c.(475-477)gGc>gAc	p.G159D	CAPN5_uc001oxx.3_Missense_Mutation_p.G119D|CAPN5_uc009yuq.3_Missense_Mutation_p.G155D|CAPN5_uc001oxy.3_Missense_Mutation_p.G159D	NM_004055	NP_004046	O15484	CAN5_HUMAN	Homo sapiens calpain 5 (CAPN5), mRNA.	119	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						GCCTACGCGGGCATCTTCCAC	0.607000													3	63					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726233	46726233	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr11:46726233A>C	uc001nde.2	+	4	1264	c.983A>C	c.(982-984)cAg>cCg	p.Q328P	ZNF408_uc010rgw.2_Missense_Mutation_p.Q320P	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	Homo sapiens zinc finger protein 408 (ZNF408), transcript variant 1, mRNA.	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCTGGAGCCCAGCAGTCTGGC	0.647000													13	31					0	0	1	0	0
TIMM50	92609	broad.mit.edu	37	19	39971399	39971399	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:39971399A>C	uc002olu.1	+	0	348	c.215A>C	c.(214-216)cAc>cCc	p.H72P	TIMM50_uc002olt.1_Non-coding_Transcript	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	Homo sapiens translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) (TIMM50), nuclear gene encoding mitochondrial protein, mRNA.	47					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	RNA binding|interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding			NS(1)|endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)	14	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCTTCCGTCCACCCGCCCCTC	0.697000													6	39					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825221	95825221	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr11:95825221C>T	uc001pfw.1	-	1	3259	c.1974G>A	c.(1972-1974)caG>caA	p.Q658Q		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	658					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgctgctgctgttgttgct	0.527000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								3	44					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242196033	242196033	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:242196033T>C	uc002waz.3	-	5	812	c.639A>G	c.(637-639)ttA>ttG	p.L213L	HDLBP_uc002wba.3_Silent_p.L213L|HDLBP_uc021vzg.1_Silent_p.L249L|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	Homo sapiens high density lipoprotein binding protein (HDLBP), transcript variant 2, mRNA.	213	KH 1.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	RNA binding|lipid binding|protein binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CAGAGATGAGTAAGACTTCAT	0.567000													34	86					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100485329	100485329	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr7:100485329T>C	uc003uwy.2	+	16	2442	c.2175T>C	c.(2173-2175)ccT>ccC	p.P725P	SRRT_uc010lhl.1_Silent_p.P724P|SRRT_uc003uxa.2_Silent_p.P724P|SRRT_uc003uwz.2_Silent_p.P725P	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	Homo sapiens serrate RNA effector molecule homolog (Arabidopsis) (SRRT), transcript variant 1, mRNA.	725					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCCAGGGTCCTGAGTTTGTGC	0.527000													47	99					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87049331	87049331	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr7:87049331T>C	uc003uiv.1	-	18	2453	c.2377A>G	c.(2377-2379)Aaa>Gaa	p.K793E	ABCB4_uc003uiw.1_Missense_Mutation_p.K793E|ABCB4_uc003uix.1_Missense_Mutation_p.K793E	NM_018849	NP_061337	P21439	MDR3_HUMAN	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4), transcript variant B, mRNA.	793	ABC transmembrane type-1 2.				cellular lipid metabolic process	Golgi membrane|apical plasma membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGCATTGCTTTAAAAGCCATT	0.423000													53	72					0	0	1	0	0
LOC283922	283922	broad.mit.edu	37	16	74372765	74372765	+	Missense_Mutation	SNP	T	T	C	rs2549261	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr16:74372765T>C	uc002fcr.2	-	8	1540	c.194A>G	c.(193-195)cAc>cGc	p.H65R	LOC283922_uc010vms.1_Non-coding_Transcript					Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit pseudogene (LOC283922), non-coding RNA.																		GAAGTCCCAGTGGGGAACCTT	0.502000													4	75					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	20739778	20739778	+	Missense_Mutation	SNP	G	G	C	rs139954896		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr6:20739778G>C	uc003ndd.2	+	5	567	c.400G>C	c.(400-402)Gta>Cta	p.V134L	CDKAL1_uc003nde.2_Missense_Mutation_p.V64L|CDKAL1_uc021ymk.1_Missense_Mutation_p.V134L	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	Homo sapiens CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), mRNA.	134	MTTase N-terminal.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CAAGAAAATCGTACTGGCTGG	0.433000													10	28					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	GL000192.1	222735	222735	+	RNA	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chrGL000192.1:222735T>C	uc010yij.1	-	17		c.3188A>G				NM_017558		Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 2, mRNA.											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTCTGCTTCTGAGAGTTCTT	0.378000													3	12					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62496852	62496852	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr17:62496852G>C	uc010deh.2	-	11	1299	c.1256C>G	c.(1255-1257)cCt>cGt	p.P419R	DDX5_uc002jek.2_Missense_Mutation_p.P419R|DDX5_uc002jej.2_Missense_Mutation_p.P314R|DDX5_uc010wqa.1_Missense_Mutation_p.P340R	NM_004396	NP_004387	P17844	DDX5_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5), mRNA.	419	Helicase C-terminal.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|RNA helicase activity|mRNA binding|protein binding|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TGAGGAGTTAGGGTAGTCATA	0.403000			T	ETV4	prostate								25	81					0	0	1	0	0
IK	3550	broad.mit.edu	37	5	140034136	140034136	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr5:140034136A>C	uc003lgq.3	+	6	665	c.555A>C	c.(553-555)gaA>gaC	p.E185D	IK_uc011czk.1_Missense_Mutation_p.E185D|IK_uc021yen.1_Missense_Mutation_p.E126D	NM_006083	NP_006074	Q13123	RED_HUMAN	Homo sapiens IK cytokine, down-regulator of HLA II (IK), mRNA.	185	Poly-Glu.				cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAGAGGAAGAGGAACTGA	0.388000													140	267					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85851274	85851274	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr3:85851274G>C	uc003dql.3	+	1	145	c.145G>C	c.(145-147)Gat>Cat	p.D49H	CADM2_uc003dqj.3_Missense_Mutation_p.D47H|CADM2_uc003dqk.3_Missense_Mutation_p.D56H|CADM2_uc003dqm.2_5'UTR|CADM2_uc021xay.1_5'UTR|CADM2_uc021xaz.1_5'UTR|CADM2_uc021xba.1_Intron	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	Homo sapiens cell adhesion molecule 2 (CADM2), transcript variant 3, mRNA.	47	Ig-like V-type.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane		p.D49E(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTGCAGGGTTGATCAAAATGA	0.408000													4	87					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220342479	220342479	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:220342479T>C	uc010fwg.3	+	20	4798	c.4798T>C	c.(4798-4800)Ttt>Ctt	p.F1600L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	Homo sapiens SPEG complex locus (SPEG), transcript variant 1, mRNA.	1600					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACTCAGCGACTTTTATGACAT	0.612000													39	30					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70209856	70209856	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr10:70209856T>C	uc021pru.1	-	5	1126	c.1126A>G	c.(1126-1128)Aca>Gca	p.T376A	DNA2_uc021prt.1_Missense_Mutation_p.T376A|DNA2_uc001jog.2_Missense_Mutation_p.T290A|DNA2_uc001joh.2_Non-coding_Transcript	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	Homo sapiens DNA replication helicase 2 homolog (yeast) (DNA2), mRNA.	290					DNA replication, removal of RNA primer|S phase of mitotic cell cycle|base-excision repair|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						TTGTATTTTGTTTTATACCCT	0.343000													32	46					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70989617	70989617	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:70989617A>C	uc021rvs.1	-	0	2008	c.2008T>G	c.(2008-2010)Tgc>Ggc	p.C670G	ADAM20_uc001xme.3_Missense_Mutation_p.C670G	NM_003814	NP_003805	O43506	ADA20_HUMAN	Homo sapiens ADAM metallopeptidase domain 20 (ADAM20), mRNA.	620					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TTACGGATGCAGATCTTTTCT	0.463000													33	63					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61467549	61467549	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr20:61467549G>T	uc002ydm.3	+	27	1415	c.1412G>T	c.(1411-1413)cGa>cTa	p.R471L	COL9A3_uc002ydn.3_5'Flank	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	Homo sapiens collagen, type IX, alpha 3 (COL9A3), mRNA.	471	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					TCTGGCAGTCGAGGGGAGCTG	0.716000													21	48					6.33239e-15	7.13303e-15	1	1	0
EXD2	55218	broad.mit.edu	37	14	69697234	69697234	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:69697234G>C	uc001xky.3	+	4	882	c.636G>C	c.(634-636)gaG>gaC	p.E212D	EXD2_uc001xkt.3_Missense_Mutation_p.E87D|EXD2_uc001xkv.3_Missense_Mutation_p.E212D|EXD2_uc001xkw.3_Missense_Mutation_p.E87D|EXD2_uc001xku.3_5'UTR|EXD2_uc001xkx.3_Missense_Mutation_p.E87D|EXD2_uc010aqt.3_Missense_Mutation_p.E212D|EXD2_uc010tte.2_Missense_Mutation_p.E212D	NM_001193360	NP_060669	Q9NVH0	EXD2_HUMAN	Homo sapiens exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1, mRNA.	87					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CCCTCGCTGAGACTGTTTTGA	0.448000													18	37					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49659052	49659052	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr10:49659052C>G	uc001jgu.3	-	8	1465	c.1168G>C	c.(1168-1170)Gag>Cag	p.E390Q	ARHGAP22_uc001jgs.3_Missense_Mutation_p.E284Q|ARHGAP22_uc001jgt.3_Missense_Mutation_p.E374Q|ARHGAP22_uc010qgl.2_Missense_Mutation_p.E331Q|ARHGAP22_uc010qgm.2_Missense_Mutation_p.E380Q|ARHGAP22_uc001jgv.3_Missense_Mutation_p.E72Q|ARHGAP22_uc001jgr.3_Missense_Mutation_p.E91Q	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Homo sapiens Rho GTPase activating protein 22 (ARHGAP22), transcript variant 3, mRNA.	374					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTGGTGACCTCCTCGGAGCCC	0.731000													25	31					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49390815	49390815	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr12:49390815A>T	uc001rsv.1	-	1	1862	c.1844T>A	c.(1843-1845)gTg>gAg	p.V615E		NM_015086	NP_055901	O94850	DEND_HUMAN	Homo sapiens dendrin (DDN), mRNA.	615	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						GATACGGGACACGGCTTCTCG	0.721000													11	14					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112026372	112026372	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:112026372G>T	uc001ebf.3	-	5	1748	c.981C>A	c.(979-981)aaC>aaA	p.N327K	ADORA3_uc001ebg.4_Missense_Mutation_p.N246K	NM_020683	NP_065734	P33765	AA3R_HUMAN	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant 1, mRNA.	0					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GCTTCAAAGTGTTGCCTACTT	0.418000													4	88					1.23904e-05	1.31985e-05	1	1	0
PASK	23178	broad.mit.edu	37	2	242082279	242082279	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:242082279G>T	uc002wao.2	-	1	302	c.169C>A	c.(169-171)Ctc>Atc	p.L57I	PASK_uc010zol.2_Missense_Mutation_p.D5E|PASK_uc010zom.2_Missense_Mutation_p.L57I|PASK_uc010fzl.2_Missense_Mutation_p.L57I|PASK_uc010zon.2_Intron|PASK_uc021vzf.1_Missense_Mutation_p.L57I|PASK_uc002waq.3_Missense_Mutation_p.L57I	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	Homo sapiens PAS domain containing serine/threonine kinase (PASK), transcript variant 2, mRNA.	57					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CTCTGGCAGAGTCTGGAAAGC	0.562000													27	22					3.73988e-18	4.26173e-18	1	1	0
SCFD1	23256	broad.mit.edu	37	14	31175075	31175075	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:31175075A>T	uc001wqm.1	+	17	1561	c.1537A>T	c.(1537-1539)Acc>Tcc	p.T513S	SCFD1_uc001wqn.1_Missense_Mutation_p.T446S|SCFD1_uc010tpg.1_Missense_Mutation_p.T454S|SCFD1_uc010tph.1_Missense_Mutation_p.T328S|SCFD1_uc010amf.1_Missense_Mutation_p.T328S|SCFD1_uc010tpi.1_Missense_Mutation_p.T421S|SCFD1_uc010amd.1_Missense_Mutation_p.T345S	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	Homo sapiens sec1 family domain containing 1 (SCFD1), transcript variant 1, mRNA.	513					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	Golgi cisterna membrane|Golgi-associated vesicle|cis-Golgi network|endoplasmic reticulum membrane|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TGGCAGCACTACCACTAAACC	0.373000													20	41					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91403569	91403569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:91403569G>T	uc001dnw.3	-	3	3444	c.3161C>A	c.(3160-3162)tCa>tAa	p.S1054*	ZNF644_uc001dnv.3_Intron|ZNF644_uc001dnx.3_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA.	1054					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AACATGATTTGATAATCCAAT	0.363000													14	21					1.05317e-09	1.15967e-09	1	1	0
ULK3	25989	broad.mit.edu	37	15	75132623	75132623	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr15:75132623C>T	uc010ulq.1	-	5	684	c.681G>A	c.(679-681)agG>agA	p.R227R	ULK3_uc010ulp.1_Silent_p.R126R|ULK3_uc010ulr.1_Silent_p.R99R|ULK3_uc010bkf.1_Silent_p.R216R|ULK3_uc002ayv.2_Silent_p.R216R|ULK3_uc010uls.1_Silent_p.R99R|ULK3_uc010ult.1_3'UTR|ULK3_uc010ulu.1_3'UTR	NM_001099436	NP_001092906	Q6PHR2	ULK3_HUMAN	Homo sapiens unc-51-like kinase 3 (C. elegans) (ULK3), mRNA.	216	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						CCGAGAACGACCTGGAGGCAA	0.652000													14	20					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48809814	48809814	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr8:48809814C>G	uc003xqi.3	-	29	3562	c.3505G>C	c.(3505-3507)Gtc>Ctc	p.V1169L	PRKDC_uc003xqj.3_Missense_Mutation_p.V1169L	NM_006904	NP_008835	P78527	PRKDC_HUMAN	Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1, mRNA.	1169					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGCCACTTGACCAGATCCAAT	0.438000								Non-homologous end-joining					26	37					0	0	1	0	0
C14orf101	54916	broad.mit.edu	37	14	57072352	57072352	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:57072352A>C	uc001xcm.3	+	4	709	c.587A>C	c.(586-588)tAt>tCt	p.Y196S	C14orf101_uc001xcj.3_Non-coding_Transcript|C14orf101_uc001xck.3_Missense_Mutation_p.Y196S|C14orf101_uc010aot.1_Missense_Mutation_p.Y196S|C14orf101_uc001xcl.1_Non-coding_Transcript|C14orf101_uc001xcn.3_Non-coding_Transcript|C14orf101_uc010trf.2_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	Homo sapiens chromosome 14 open reading frame 101 (C14orf101), mRNA.	196						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(311;0.226)		ATAATACTCTATGTTTTGTGC	0.264000													32	62					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935595	227935595	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:227935595T>A	uc001hrf.2	+	1	707	c.293T>A	c.(292-294)aTa>aAa	p.I98K	SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.3_Missense_Mutation_p.I98K|SNAP47_uc001hre.3_Intron	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	Homo sapiens synaptosomal-associated protein, 47kDa (SNAP47), mRNA.	98						endomembrane system|membrane|perinuclear region of cytoplasm				endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17						CTCTCCAGCATAGTTGAGATC	0.532000													33	45					0	0	1	0	0
CLDN9	9080	broad.mit.edu	37	16	3063765	3063765	+	Silent	SNP	C	C	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr16:3063765C>A	uc010uwo.1	+	0	1309	c.402C>A	c.(400-402)atC>atA	p.I134I		NM_020982	NP_066192	O95484	CLD9_HUMAN	Homo sapiens claudin 9 (CLDN9), mRNA.	134					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						TGGTGCTCATCCCTGTGTGCT	0.662000													48	40					1.07234e-20	1.23635e-20	1	1	0
CEACAM16	388551	broad.mit.edu	37	19	45211204	45211204	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:45211204G>A	uc010xxd.2	+	5	1218	c.1012G>A	c.(1012-1014)Gtg>Atg	p.V338M		NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16), mRNA.	338										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				AACACTGACCGTGCAGGGCTA	0.672000													22	52					0	0	1	0	0
RPL19	6143	broad.mit.edu	37	17	37358657	37358657	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr17:37358657C>T	uc002hrq.1	+	2	262	c.200C>T	c.(199-201)aCc>aTc	p.T67I		NM_000981	NP_000972	P84098	RL19_HUMAN	Homo sapiens ribosomal protein L19 (RPL19), mRNA.	67					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7						CGGAAAAACACCTTGGCCCGC	0.522000													42	43					0	0	1	0	0
KIAA2012	0	broad.mit.edu	37	2	202939695	202939695	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:202939695T>A	uc010zhu.1	+	1	539	c.166T>A	c.(166-168)Tgg>Agg	p.W56R	KIAA2012_uc010ftp.2_Missense_Mutation_p.W56R					SubName: Full=cDNA FLJ52575;																		TCAGCACTCCTGGAGCCTCTT	0.483000													32	119					0	0	1	0	0
RAB31	11031	broad.mit.edu	37	18	9815181	9815181	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr18:9815181G>T	uc002kog.2	+	4	517	c.342G>T	c.(340-342)atG>atT	p.M114I		NM_006868	NP_006859	Q13636	RAB31_HUMAN	Homo sapiens RAB31, member RAS oncogene family (RAB31), mRNA.	113					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(3)|skin(1)	10						ACATTGTAATGGCCATCGCTG	0.403000													3	69					0.150653	0.152207	1	1	0
RFX1	5989	broad.mit.edu	37	19	14080923	14080923	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr19:14080923T>C	uc002mxv.3	-	9	1651	c.1379A>G	c.(1378-1380)tAc>tGc	p.Y460C	RFX1_uc010dzi.2_Missense_Mutation_p.Y460C	NM_002918	NP_002909	P22670	RFX1_HUMAN	Homo sapiens regulatory factor X, 1 (influences HLA class II expression) (RFX1), mRNA.	460					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GTAGTGGCAGTAGAGGGTGCT	0.627000													3	88					0	0	1	0	0
RMND5A	64795	broad.mit.edu	37	2	86947925	86947925	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr2:86947925G>A	uc002srr.2	+	0	512	c.135G>A	c.(133-135)caG>caA	p.Q45Q	RMND5A_uc002srs.4_5'UTR|RNF103_uc010ytl.2_Intron	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae) (RMND5A), mRNA.	45										kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						AGATCCTGCAGAGCCACGGTA	0.726000													19	26					0	0	1	0	0
C14orf43	91748	broad.mit.edu	37	14	74206660	74206660	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:74206660A>T	uc010tud.1	-	0	299	c.52T>A	c.(52-54)Ttc>Atc	p.F18I	C14orf43_uc001xot.3_Missense_Mutation_p.F18I|C14orf43_uc001xou.3_Missense_Mutation_p.F18I|C14orf43_uc010arw.2_Non-coding_Transcript	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	Homo sapiens chromosome 14 open reading frame 43 (C14orf43), transcript variant 1, mRNA.	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(4)	37				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		TGGCCCCCGAAGAGGCAACGC	0.652000													14	23					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944059	74944059	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr17:74944059G>T	uc002jti.3	+	14	2201	c.2098G>T	c.(2098-2100)Gcc>Tcc	p.A700S	MGAT5B_uc002jth.3_Missense_Mutation_p.A689S|MGAT5B_uc002jtj.3_Missense_Mutation_p.A96S	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B), transcript variant 2, mRNA.	691						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGCCCTGCGGGCCTGGCTGGC	0.701000													6	32					2.7689e-08	3.01502e-08	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1087140	1087140	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr5:1087140A>C	uc003jbu.3	-	5	619	c.553T>G	c.(553-555)Tcc>Gcc	p.S185A		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	Homo sapiens solute carrier family 12 (potassium/chloride transporters), member 7 (SLC12A7), mRNA.	185					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ATGTAGTAGGACCCGCCAGCT	0.637000													6	77					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68252617	68252617	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr14:68252617C>T	uc001xka.2	-	17	3401	c.3262G>A	c.(3262-3264)Gat>Aat	p.D1088N	ZFYVE26_uc010tsz.1_Non-coding_Transcript|ZFYVE26_uc001xkc.4_Missense_Mutation_p.D1088N	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	Homo sapiens zinc finger, FYVE domain containing 26 (ZFYVE26), mRNA.	1088					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGGACCTGATCTAGCTGCTGG	0.557000													24	49					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2066777	2066777	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr1:2066777C>T	uc001aiq.3	+	4	572	c.411C>T	c.(409-411)cgC>cgT	p.R137R	PRKCZ_uc001air.3_5'UTR|PRKCZ_uc010nyw.2_Silent_p.R33R|PRKCZ_uc001ais.3_5'UTR	NM_002744	NP_001028754	Q05513	KPCZ_HUMAN	Homo sapiens protein kinase C, zeta (PRKCZ), transcript variant 1, mRNA.	137	Interaction with SQSTM1 (By similarity).				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		AAGCCAAGCGCTTTAACAGGG	0.552000													16	10					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140256291	140256291	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr5:140256291G>A	uc003lic.2	+	0	1361	c.1234G>A	c.(1234-1236)Gcc>Acc	p.A412T	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc003lhx.2_Intron|PCDHAC2_uc003lia.2_Intron|PCDHAC2_uc011daf.2_Missense_Mutation_p.A412T	NM_018903	NP_061726	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 12 (PCDHA12), transcript variant 1, mRNA.	426	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACAGCGCCCTGGACCG	0.607000													8	141					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165948982	165948982	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:165948982A>G	uc002ucx.3	-	26	5081	c.4589T>C	c.(4588-4590)aTc>aCc	p.I1530T	SCN3A_uc010zcy.2_Missense_Mutation_p.I13T|SCN3A_uc002ucy.3_Missense_Mutation_p.I1481T|SCN3A_uc002ucz.3_Missense_Mutation_p.I1481T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	Homo sapiens sodium channel, voltage-gated, type III, alpha subunit (SCN3A), transcript variant 1, mRNA.	1530						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CATGATGCTGATATCAAAGAC	0.388000													114	99					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113176133	113176133	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:113176133C>T	uc003eag.4	-	12	1798	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	SPICE1_uc003eaf.4_Non-coding_Transcript|SPICE1_uc003eah.1_Missense_Mutation_p.E399K	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	Homo sapiens spindle and centriole associated protein 1 (SPICE1), mRNA.	503					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GGCAACTCTTCCTGTGGGAAT	0.448000													40	58					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52404725	52404725	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr15:52404725A>T	uc002abq.3	-	0	248	c.199T>A	c.(199-201)Tac>Aac	p.Y67N		NM_020396	NP_065129	Q9HD36	B2L10_HUMAN	Homo sapiens BCL2-like 10 (apoptosis facilitator) (BCL2L10), mRNA.	57					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		TAGCCGAGGTAGGCGGAGAAA	0.716000													11	17					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140800833	140800833	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr5:140800833G>A	uc003lkq.2	+	0	297	c.39G>A	c.(37-39)ctG>ctA	p.L13L	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljq.2_Intron|PCDHGC5_uc003ljs.2_Intron|PCDHGC5_uc003lju.2_Intron|PCDHGC5_uc003ljw.2_Intron|PCDHGC5_uc003ljy.2_Intron|PCDHGC5_uc003lka.2_Intron|PCDHGC5_uc003lkc.2_Intron|PCDHGC5_uc003lkd.2_Intron|PCDHGC5_uc003lkf.2_Intron|PCDHGC5_uc003lkh.2_Intron|PCDHGC5_uc003lkj.2_Intron|PCDHGC5_uc003lkl.2_Intron|PCDHGC5_uc003lkn.2_Intron|PCDHGC5_uc003lko.1_Silent_p.L13L|PCDHGC5_uc003lkp.2_Silent_p.L13L	NM_018914	NP_061737	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant 1, mRNA.	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTCGGCTGCTGCTGCTGC	0.607000													12	22					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825221	95825221	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:95825221C>T	uc001pfw.1	-	1	3259	c.1974G>A	c.(1972-1974)caG>caA	p.Q658Q		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	658					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgctgctgctgttgttgct	0.527000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								3	44					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123596282	123596282	+	Missense_Mutation	SNP	T	T	C	rs148135505	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr10:123596282T>C	uc001lfp.3	-	9	1290	c.1208A>G	c.(1207-1209)tAt>tGt	p.Y403C	ATE1_uc001lfq.3_Missense_Mutation_p.Y403C|ATE1_uc010qtr.2_Missense_Mutation_p.Y288C|ATE1_uc010qts.2_Missense_Mutation_p.Y307C|ATE1_uc010qtt.2_Missense_Mutation_p.Y396C|ATE1_uc001lfr.3_Missense_Mutation_p.Y104C|ATE1_uc009xzu.3_Non-coding_Transcript	NM_007041	NP_008972	O95260	ATE1_HUMAN	Homo sapiens arginyltransferase 1 (ATE1), transcript variant 2, mRNA.	403					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				CATATAATAATAGCTGAGTTG	0.308000													4	240					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195515304	195515304	+	Silent	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:195515304T>A	uc021xjp.1	-	1	3303	c.3147A>T	c.(3145-3147)gcA>gcT	p.A1049A	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	1048					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A1049A(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CACCTGTGGATGCTGAGGAAA	0.562000													3	52					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90180077	90180077	+	Missense_Mutation	SNP	A	A	G	rs113075842		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:90180077A>G	uc001dnl.4	+	2	2190	c.1948A>G	c.(1948-1950)Acc>Gcc	p.T650A		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member C (LRRC8C), mRNA.	650						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TAACAGCATCACCTACATCCC	0.418000													34	72					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892799	166892799	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:166892799G>A	uc002udo.4	-	17	3415	c.3188C>T	c.(3187-3189)tCc>tTc	p.S1063F	SCN1A_uc010fpk.3_Missense_Mutation_p.S1035F|SCN1A_uc021vsb.1_Missense_Mutation_p.S1052F	NM_001202435	NP_001189364	P35498	SCN1A_HUMAN	Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 4, mRNA.	1063						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGTATGATTGGACATACAACT	0.313000													42	150					0	0	1	0	0
ZIC2	7546	broad.mit.edu	37	13	100635322	100635322	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr13:100635322G>A	uc001von.3	+	0	1297	c.1004G>A	c.(1003-1005)tGc>tAc	p.C335Y		NM_007129	NP_009060	O95409	ZIC2_HUMAN	Homo sapiens Zic family member 2 (ZIC2), mRNA.	335			C -> F (in HPE5).		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCTTCCCCTGCCCCTTCCCG	0.617000													22	55					0	0	1	0	0
TOB1	10140	broad.mit.edu	37	17	48941072	48941072	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:48941072T>A	uc002isw.3	-	1	750	c.307A>T	c.(307-309)Att>Ttt	p.I103F	TOB1_uc021uac.1_5'UTR|TOB1_uc010wmz.2_Missense_Mutation_p.I103F|TOB1_uc021uad.1_Missense_Mutation_p.I103F|LOC400604_uc002isy.3_5'Flank	NM_005749	NP_005740	P50616	TOB1_HUMAN	Homo sapiens transducer of ERBB2, 1 (TOB1), transcript variant 1, mRNA.	103					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TTTTCACCAATTTGGTAAGAA	0.423000											OREG0024576	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	119					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43793933	43793933	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:43793933G>A	uc002rsw.4	-	14	2567	c.2215C>T	c.(2215-2217)Ctt>Ttt	p.L739F	THADA_uc010far.3_Missense_Mutation_p.L8F|THADA_uc002rsx.4_Missense_Mutation_p.L739F|THADA_uc002rsy.4_Non-coding_Transcript|THADA_uc010fas.1_Non-coding_Transcript|THADA_uc002rsz.3_Missense_Mutation_p.L449F|THADA_uc010fat.1_Missense_Mutation_p.L8F|THADA_uc002rta.2_Missense_Mutation_p.L449F|THADA_uc002rtb.1_Missense_Mutation_p.L739F|THADA_uc002rtc.4_Missense_Mutation_p.L739F|THADA_uc002rtd.3_Missense_Mutation_p.L739F	NM_001083953	NP_071348	Q6YHU6	THADA_HUMAN	Homo sapiens thyroid adenoma associated (THADA), transcript variant 3, mRNA.	739							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GCTTCAAAAAGACTGTTACAA	0.308000													10	149					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	623528	623528	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:623528T>C	uc002lpf.1	-	5	1272	c.1216A>G	c.(1216-1218)Atg>Gtg	p.M406V		NM_005035	NP_005026	O00411	RPOM_HUMAN	Homo sapiens polymerase (RNA) mitochondrial (DNA directed) (POLRMT), nuclear gene encoding mitochondrial protein, mRNA.	406					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCTCCATGTGGAGCTGC	0.632000													7	34					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3230734	3230734	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr4:3230734T>C	uc021xkv.1	+	58	8252	c.8107T>C	c.(8107-8109)Tcc>Ccc	p.S2703P		NM_002111	NP_002102	P42858	HD_HUMAN	Homo sapiens huntingtin (HTT), mRNA.	2703					Golgi organization|establishment of mitotic spindle orientation|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	Golgi apparatus|autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGTGGTCAGATCCGTAAGTGA	0.602000													20	32					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223536686	223536686	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:223536686T>C	uc001hnx.3	-	0	716	c.82A>G	c.(82-84)Aga>Gga	p.R28G	SUSD4_uc001hny.4_Missense_Mutation_p.R28G|SUSD4_uc010puw.2_5'UTR|SUSD4_uc001hnz.2_Missense_Mutation_p.R28G|SUSD4_uc010pux.1_Missense_Mutation_p.R28G	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	Homo sapiens sushi domain containing 4 (SUSD4), transcript variant 1, mRNA.	28						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GCCAAGAGTCTCTGGGGGGAC	0.597000													37	78					0	0	1	0	0
C2orf28	51374	broad.mit.edu	37	2	27436144	27436144	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:27436144A>G	uc002rjf.3	+	1	537	c.364A>G	c.(364-366)Aat>Gat	p.N122D	SLC5A6_uc002rjd.3_5'Flank|SLC5A6_uc010eyv.1_5'Flank|SLC5A6_uc002rje.1_5'Flank|C2orf28_uc002rjg.3_Missense_Mutation_p.N9D	NM_001170795	NP_001164266	Q6UW56	APR3_HUMAN	Homo sapiens chromosome 2 open reading frame 28 (C2orf28), transcript variant 3, mRNA.	67						integral to membrane|plasma membrane				large_intestine(2)|lung(2)|skin(2)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCTGCCTGAATCAGAAGGG	0.468000													20	55					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30492406	30492406	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:30492406G>A	uc003tav.3	-	5	1150	c.627C>T	c.(625-627)tcC>tcT	p.S209S	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	Homo sapiens nucleotide-binding oligomerization domain containing 1 (NOD1), mRNA.	209	NACHT.				JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of dendritic cell antigen processing and presentation|protein oligomerization|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						GTAGCAGCATGGACTTGCCCA	0.612000													21	43					0	0	1	0	0
TMEM178	130733	broad.mit.edu	37	2	39934299	39934299	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:39934299G>T	uc002rrt.3	+	2	705	c.625G>T	c.(625-627)Gtg>Ttg	p.V209L	TMEM178_uc021vgg.1_Missense_Mutation_p.V27L|TMEM178_uc010fam.2_Intron	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	Homo sapiens transmembrane protein 178 (TMEM178), transcript variant 1, mRNA.	209						integral to membrane				endometrium(1)|large_intestine(5)|lung(5)	11		all_hematologic(82;0.248)				GACCCAGCACGTGGCTGGACT	0.602000													3	86					6.4e-05	6.5641e-05	1	1	0
GRIA4	2893	broad.mit.edu	37	11	105623882	105623882	+	Silent	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:105623882A>T	uc001pix.2	+	3	869	c.423A>T	c.(421-423)gcA>gcT	p.A141A	GRIA4_uc001piu.1_Silent_p.A141A|GRIA4_uc001piw.2_Silent_p.A141A|GRIA4_uc001piv.3_Silent_p.A141A|GRIA4_uc009yxk.1_Silent_p.A141A	NM_000829	NP_000820	P48058	GRIA4_HUMAN	Homo sapiens glutamate receptor, ionotrophic, AMPA 4 (GRIA4), transcript variant 1, mRNA.	141					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TACGAGGAGCACTCTTGAGTT	0.468000													36	76					0	0	1	0	0
LYZ	4069	broad.mit.edu	37	12	69743944	69743944	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr12:69743944G>T	uc001suw.2	+	1	248	c.193G>T	c.(193-195)Gct>Tct	p.A65S		NM_000239	NP_000230	P61626	LYSC_HUMAN	Homo sapiens lysozyme (LYZ), mRNA.	65					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)	4	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			AAACTACAATGCTGGAGACAG	0.408000													61	126					4.09106e-26	4.6755e-26	1	1	0
DTX2P1-UPK3BP1-PMS2P11	441263	broad.mit.edu	37	7	76610152	76610152	+	RNA	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:76610152G>A	uc011kgn.1	+	0		c.14G>A			DTX2P1-UPK3BP1-PMS2P11_uc003ufw.4_Non-coding_Transcript					Homo sapiens DTX2P1-UPK3BP1-PMS2P11 readthrough (non-protein coding) (DTX2P1-UPK3BP1-PMS2P11), non-coding RNA.																		CCCACACGCAGACCAACAAGA	0.637000													98	144					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53077753	53077753	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr8:53077753G>T	uc003xqz.2	-	6	1393	c.1237C>A	c.(1237-1239)Ccc>Acc	p.P413T	ST18_uc011ldq.1_Missense_Mutation_p.P60T|ST18_uc011ldr.1_Missense_Mutation_p.P378T|ST18_uc011lds.1_Missense_Mutation_p.P318T|ST18_uc003xra.2_Missense_Mutation_p.P413T|ST18_uc003xrb.2_Missense_Mutation_p.P413T	NM_014682	NP_055497	O60284	ST18_HUMAN	Homo sapiens suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) (ST18), mRNA.	413						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCCGGCGTGGGACACTTGAGC	0.403000													3	42					1	1	1	1	0
FTSJ2	29960	broad.mit.edu	37	7	2275155	2275155	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:2275155G>T	uc003slm.3	-	2	372	c.343C>A	c.(343-345)Cac>Aac	p.H115N	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.3_5'Flank|FTSJ2_uc003sln.3_Non-coding_Transcript|FTSJ2_uc003slo.3_5'UTR	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	Homo sapiens FtsJ homolog 2 (E. coli) (FTSJ2), mRNA.	115					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GGGAATATGTGAAGAAGATCT	0.478000													23	40					7.4402e-23	8.42287e-23	1	1	0
CYP4A11	1579	broad.mit.edu	37	1	47395874	47395874	+	Missense_Mutation	SNP	A	A	C	rs148507594	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:47395874A>C	uc001cqp.4	-	11	1524	c.1473T>G	c.(1471-1473)atT>atG	p.I491M		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 11 (CYP4A11), mRNA.	491					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding	p.I491M(2)		endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	CAAGTCGTGCAATGGGGATGG	0.562000													5	94					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	19	36229181	36229181	+	Splice_Site	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:36229181A>G	uc021usv.1	+	37	7873	c.7873_splice	c.e37-2	p.G2625_splice	MLL2_uc021usu.1_Splice_Site_p.G1439_splice	NM_014727	NP_055542	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4), mRNA.	5447	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						TCATCCCTGCAGGGCATCGGG	0.602000			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)			10	20					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71036918	71036918	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:71036918G>A	uc002shf.3	-	5	1688	c.1611C>T	c.(1609-1611)tcC>tcT	p.S537S	CLEC4F_uc010yqv.1_Silent_p.S537S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	Homo sapiens C-type lectin domain family 4, member F (CLEC4F), mRNA.	537	C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TCCAGCGCCAGGAGCCCTCTG	0.552000													23	51					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59274493	59274493	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr12:59274493G>A	uc001sqr.3	-	12	1917	c.1671C>T	c.(1669-1671)ggC>ggT	p.G557G	LRIG3_uc009zqh.3_Silent_p.G497G|LRIG3_uc010ssh.2_Non-coding_Transcript	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3), transcript variant 2, mRNA.	557	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CCATCACCTCGCCACCTTGGG	0.483000			T	ROS1	NSCLC								4	135					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610566	10610566	+	Silent	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:10610566G>T	uc002moq.1	-	1	300	c.144C>A	c.(142-144)ggC>ggA	p.G48G	KEAP1_uc002mor.1_Silent_p.G48G	NM_012289	NP_987096	Q14145	KEAP1_HUMAN	Homo sapiens kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2, mRNA.	48					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AGGTGCGGTTGCCATGCTGGG	0.627000													22	33					6.44725e-10	7.03337e-10	1	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125826081	125826081	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:125826081A>C	uc003eim.1	-	20	2546	c.2356T>G	c.(2356-2358)Ttt>Gtt	p.F786V	ALDH1L1_uc010hse.1_Non-coding_Transcript|ALDH1L1_uc011bki.1_Missense_Mutation_p.F685V|ALDH1L1_uc003ein.1_Missense_Mutation_p.F321V	NM_012190	NP_036322	O75891	AL1L1_HUMAN	Homo sapiens aldehyde dehydrogenase 1 family, member L1 (ALDH1L1), mRNA.	786	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GTTGGCTCAAAGAAGAACCCT	0.557000													31	18					0	0	1	0	0
ZNF273	10793	broad.mit.edu	37	7	64388953	64388953	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:64388953C>G	uc003tto.3	+	3	1323	c.1247C>G	c.(1246-1248)aCt>aGt	p.T416S	ZNF273_uc003ttl.3_Missense_Mutation_p.T351S|ZNF273_uc003ttn.3_Missense_Mutation_p.T351S	NM_021148	NP_066971	Q14593	ZN273_HUMAN	Homo sapiens zinc finger protein 273 (ZNF273), transcript variant 1, mRNA.	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CGGTCCACAACTCTTACTAAA	0.348000													63	82					0	0	1	0	0
CLDN9	9080	broad.mit.edu	37	16	3063765	3063765	+	Silent	SNP	C	C	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr16:3063765C>A	uc010uwo.1	+	0	1309	c.402C>A	c.(400-402)atC>atA	p.I134I		NM_020982	NP_066192	O95484	CLD9_HUMAN	Homo sapiens claudin 9 (CLDN9), mRNA.	134					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						TGGTGCTCATCCCTGTGTGCT	0.662000													48	40					1.07234e-20	1.20263e-20	1	1	0
NFYA	4800	broad.mit.edu	37	6	41059422	41059422	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr6:41059422G>A	uc003opo.3	+	6	881	c.703G>A	c.(703-705)Ggg>Agg	p.G235R	NFYA_uc003opp.3_Missense_Mutation_p.G206R|NFYA_uc003opq.3_Missense_Mutation_p.G206R	NM_002505	NP_002496	P23511	NFYA_HUMAN	Homo sapiens nuclear transcription factor Y, alpha (NFYA), transcript variant 1, mRNA.	235					transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	9	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAATTCAGGAGGGATGGTCAT	0.418000													17	33					0	0	1	0	0
TRIM77P	390231	broad.mit.edu	37	11	89447375	89447375	+	Missense_Mutation	SNP	C	C	T	rs17221124	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:89447375C>T	uc010rtw.2	+	2	523	c.523C>T	c.(523-525)Cgg>Tgg	p.R175W		NM_001146162	NP_001139634			Homo sapiens tripartite motif containing 77, pseudogene (TRIM77P), mRNA.																		TATAAATTTGCGGAGCATGAT	0.373000													5	156					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33810281	33810281	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:33810281T>C	uc002rpa.1	-	7	1193	c.1119A>G	c.(1117-1119)ggA>ggG	p.G373G	FAM98A_uc010yne.1_Silent_p.G178G|FAM98A_uc010ynd.1_Silent_p.G204G|FAM98A_uc002roz.1_Silent_p.G211G	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	Homo sapiens family with sequence similarity 98, member A (FAM98A), mRNA.	374	Gly-rich.							p.G372G(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					TTCCTCTTCCTCCCCCTCGGC	0.562000													3	99					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:62968690A>G	uc002jez.3	-	3		c.641T>C			AMZ2P1_uc002jfa.3_Non-coding_Transcript|AMZ2P1_uc002jfb.3_Non-coding_Transcript|AMZ2P1_uc010del.2_Non-coding_Transcript					Homo sapiens archaelysin family metallopeptidase 2 pseudogene 1 (AMZ2P1), non-coding RNA.																		AAAATTCCACAAGTCTCTTGG	0.373000													5	198					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93646100	93646100	+	Silent	SNP	C	C	T	rs6121	by1000genomes	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:93646100C>T	uc003drb.4	-	1	569	c.228G>A	c.(226-228)ccG>ccA	p.P76P	PROS1_uc010hoo.3_5'UTR|PROS1_uc003dqz.4_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	Homo sapiens protein S (alpha) (PROS1), mRNA.	76	Gla.		P -> L.		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	Golgi lumen|Golgi membrane|endoplasmic reticulum membrane|extracellular region|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity	p.D75Y(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTACCGTTTCCGGGTCATTTT	0.388000													3	101					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49689059	49689059	+	Silent	SNP	C	C	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:49689059C>A	uc003cxe.4	+	4	2184	c.2070C>A	c.(2068-2070)atC>atA	p.I690I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	Homo sapiens bassoon (presynaptic cytomatrix protein) (BSN), mRNA.	690					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGACGGCATCTCTAGCTCCC	0.602000													26	50					7.16026e-08	7.53712e-08	1	1	0
CAPN5	726	broad.mit.edu	37	11	76823693	76823693	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:76823693G>A	uc009yup.3	+	4	661	c.476G>A	c.(475-477)gGc>gAc	p.G159D	CAPN5_uc001oxx.3_Missense_Mutation_p.G119D|CAPN5_uc009yuq.3_Missense_Mutation_p.G155D|CAPN5_uc001oxy.3_Missense_Mutation_p.G159D	NM_004055	NP_004046	O15484	CAN5_HUMAN	Homo sapiens calpain 5 (CAPN5), mRNA.	119	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						GCCTACGCGGGCATCTTCCAC	0.607000													3	63					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371604	240371604	+	Silent	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:240371604A>T	uc010pye.2	+	5	3729	c.3504A>T	c.(3502-3504)ccA>ccT	p.P1168P	FMN2_uc010pyd.2_Silent_p.P1164P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	Homo sapiens formin 2 (FMN2), mRNA.	1164	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCATACCCCCACCTCCCCCTC	0.687000													6	31					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726233	46726233	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:46726233A>C	uc001nde.2	+	4	1264	c.983A>C	c.(982-984)cAg>cCg	p.Q328P	ZNF408_uc010rgw.2_Missense_Mutation_p.Q320P	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	Homo sapiens zinc finger protein 408 (ZNF408), transcript variant 1, mRNA.	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCTGGAGCCCAGCAGTCTGGC	0.647000													13	31					0	0	1	0	0
BC012753	0	broad.mit.edu	37	GL000214.1	32615	32615	+	RNA	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chrGL000214.1:32615C>T	uc011mfm.2	+	1		c.824C>T								Homo sapiens cDNA clone IMAGE:3625232, partial cds.																		CCAAGAGCAACAGGAAACGAA	0.408000													4	18					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242196033	242196033	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:242196033T>C	uc002waz.3	-	5	812	c.639A>G	c.(637-639)ttA>ttG	p.L213L	HDLBP_uc002wba.3_Silent_p.L213L|HDLBP_uc021vzg.1_Silent_p.L249L|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	Homo sapiens high density lipoprotein binding protein (HDLBP), transcript variant 2, mRNA.	213	KH 1.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	RNA binding|lipid binding|protein binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CAGAGATGAGTAAGACTTCAT	0.567000													34	86					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14439197	14439197	+	RNA	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr21:14439197G>C	uc002yja.4	+	9		c.2715G>C								Homo sapiens ankyrin repeat domain 30B pseudogene 2 (ANKRD30BP2), non-coding RNA.																		AAGAAGAAGAGAAGAGAAGAA	0.289000													2	3					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100485329	100485329	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:100485329T>C	uc003uwy.2	+	16	2442	c.2175T>C	c.(2173-2175)ccT>ccC	p.P725P	SRRT_uc010lhl.1_Silent_p.P724P|SRRT_uc003uxa.2_Silent_p.P724P|SRRT_uc003uwz.2_Silent_p.P725P	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	Homo sapiens serrate RNA effector molecule homolog (Arabidopsis) (SRRT), transcript variant 1, mRNA.	725					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCCAGGGTCCTGAGTTTGTGC	0.527000													47	99					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87049331	87049331	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:87049331T>C	uc003uiv.1	-	18	2453	c.2377A>G	c.(2377-2379)Aaa>Gaa	p.K793E	ABCB4_uc003uiw.1_Missense_Mutation_p.K793E|ABCB4_uc003uix.1_Missense_Mutation_p.K793E	NM_018849	NP_061337	P21439	MDR3_HUMAN	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4), transcript variant B, mRNA.	793	ABC transmembrane type-1 2.				cellular lipid metabolic process	Golgi membrane|apical plasma membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGCATTGCTTTAAAAGCCATT	0.423000													53	72					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220342479	220342479	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:220342479T>C	uc010fwg.3	+	20	4798	c.4798T>C	c.(4798-4800)Ttt>Ctt	p.F1600L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	Homo sapiens SPEG complex locus (SPEG), transcript variant 1, mRNA.	1600					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACTCAGCGACTTTTATGACAT	0.612000													39	30					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	20739778	20739778	+	Missense_Mutation	SNP	G	G	C	rs139954896		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr6:20739778G>C	uc003ndd.2	+	5	567	c.400G>C	c.(400-402)Gta>Cta	p.V134L	CDKAL1_uc003nde.2_Missense_Mutation_p.V64L|CDKAL1_uc021ymk.1_Missense_Mutation_p.V134L	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	Homo sapiens CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), mRNA.	134	MTTase N-terminal.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CAAGAAAATCGTACTGGCTGG	0.433000													10	28					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	GL000192.1	222735	222735	+	RNA	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chrGL000192.1:222735T>C	uc010yij.1	-	17		c.3188A>G				NM_017558		Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 2, mRNA.											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTCTGCTTCTGAGAGTTCTT	0.378000													3	12					0	0	1	0	0
PPP1CA	5499	broad.mit.edu	37	11	67168351	67168351	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr11:67168351A>C	uc001okw.1	-	2	350	c.227T>G	c.(226-228)tTt>tGt	p.F76C	PPP1CA_uc001oku.1_Missense_Mutation_p.F87C|PPP1CA_uc001okv.1_Missense_Mutation_p.F32C|PPP1CA_uc001okx.1_Missense_Mutation_p.F164C	NM_002708	NP_002699	P62136	PP1A_HUMAN	Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 1, mRNA.	76					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	MLL5-L complex|PTW/PP1 phosphatase complex|cytosol|nucleolus	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GCCATACTCAAATAGTCGCAG	0.572000													18	47					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62496852	62496852	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:62496852G>C	uc010deh.2	-	11	1299	c.1256C>G	c.(1255-1257)cCt>cGt	p.P419R	DDX5_uc002jek.2_Missense_Mutation_p.P419R|DDX5_uc002jej.2_Missense_Mutation_p.P314R|DDX5_uc010wqa.1_Missense_Mutation_p.P340R	NM_004396	NP_004387	P17844	DDX5_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5), mRNA.	419	Helicase C-terminal.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|RNA helicase activity|mRNA binding|protein binding|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TGAGGAGTTAGGGTAGTCATA	0.403000			T	ETV4	prostate								25	81					0	0	1	0	0
IK	3550	broad.mit.edu	37	5	140034136	140034136	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr5:140034136A>C	uc003lgq.3	+	6	665	c.555A>C	c.(553-555)gaA>gaC	p.E185D	IK_uc011czk.1_Missense_Mutation_p.E185D|IK_uc021yen.1_Missense_Mutation_p.E126D	NM_006083	NP_006074	Q13123	RED_HUMAN	Homo sapiens IK cytokine, down-regulator of HLA II (IK), mRNA.	185	Poly-Glu.				cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAGAGGAAGAGGAACTGA	0.388000													140	267					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85851274	85851274	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:85851274G>C	uc003dql.3	+	1	145	c.145G>C	c.(145-147)Gat>Cat	p.D49H	CADM2_uc003dqj.3_Missense_Mutation_p.D47H|CADM2_uc003dqk.3_Missense_Mutation_p.D56H|CADM2_uc003dqm.2_5'UTR|CADM2_uc021xay.1_5'UTR|CADM2_uc021xaz.1_5'UTR|CADM2_uc021xba.1_Intron	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	Homo sapiens cell adhesion molecule 2 (CADM2), transcript variant 3, mRNA.	47	Ig-like V-type.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane		p.D49E(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTGCAGGGTTGATCAAAATGA	0.408000													4	87					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935595	227935595	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:227935595T>A	uc001hrf.2	+	1	707	c.293T>A	c.(292-294)aTa>aAa	p.I98K	SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.3_Missense_Mutation_p.I98K|SNAP47_uc001hre.3_Intron	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	Homo sapiens synaptosomal-associated protein, 47kDa (SNAP47), mRNA.	98						endomembrane system|membrane|perinuclear region of cytoplasm				endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17						CTCTCCAGCATAGTTGAGATC	0.532000													33	45					0	0	1	0	0
PPP2CB	5516	broad.mit.edu	37	8	30651447	30651447	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr8:30651447G>C	uc003xik.3	-	4	1139	c.724C>G	c.(724-726)Cag>Gag	p.Q242E		NM_001009552	NP_001009552	P62714	PP2AB_HUMAN	Homo sapiens protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB), mRNA.	242					protein dephosphorylation	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex|spindle pole	metal ion binding			breast(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	9				KIRC - Kidney renal clear cell carcinoma(542;0.095)|Kidney(114;0.114)	Vitamin E(DB00163)	ATTACAAGCTGGTGGGCACGA	0.393000													110	191					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70209856	70209856	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr10:70209856T>C	uc021pru.1	-	5	1126	c.1126A>G	c.(1126-1128)Aca>Gca	p.T376A	DNA2_uc021prt.1_Missense_Mutation_p.T376A|DNA2_uc001jog.2_Missense_Mutation_p.T290A|DNA2_uc001joh.2_Non-coding_Transcript	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	Homo sapiens DNA replication helicase 2 homolog (yeast) (DNA2), mRNA.	290					DNA replication, removal of RNA primer|S phase of mitotic cell cycle|base-excision repair|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						TTGTATTTTGTTTTATACCCT	0.343000													32	46					0	0	1	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249106494	249106494	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:249106494T>A	uc001iew.1	-	6	1339	c.787A>T	c.(787-789)Aac>Tac	p.N263Y	SH3BP5L_uc010pzp.1_Missense_Mutation_p.N156Y|SH3BP5L_uc001iev.1_Missense_Mutation_p.N144Y	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	Homo sapiens SH3-binding domain protein 5-like (SH3BP5L), mRNA.	263										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TGCTCCAGGTTACGAAGGGCC	0.687000													8	31					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70989617	70989617	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:70989617A>C	uc021rvs.1	-	0	2008	c.2008T>G	c.(2008-2010)Tgc>Ggc	p.C670G	ADAM20_uc001xme.3_Missense_Mutation_p.C670G	NM_003814	NP_003805	O43506	ADA20_HUMAN	Homo sapiens ADAM metallopeptidase domain 20 (ADAM20), mRNA.	620					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TTACGGATGCAGATCTTTTCT	0.463000													33	63					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61467549	61467549	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr20:61467549G>T	uc002ydm.3	+	27	1415	c.1412G>T	c.(1411-1413)cGa>cTa	p.R471L	COL9A3_uc002ydn.3_5'Flank	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	Homo sapiens collagen, type IX, alpha 3 (COL9A3), mRNA.	471	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					TCTGGCAGTCGAGGGGAGCTG	0.716000													21	48					6.33239e-15	6.97143e-15	1	1	0
EXD2	55218	broad.mit.edu	37	14	69697234	69697234	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:69697234G>C	uc001xky.3	+	4	882	c.636G>C	c.(634-636)gaG>gaC	p.E212D	EXD2_uc001xkt.3_Missense_Mutation_p.E87D|EXD2_uc001xkv.3_Missense_Mutation_p.E212D|EXD2_uc001xkw.3_Missense_Mutation_p.E87D|EXD2_uc001xku.3_5'UTR|EXD2_uc001xkx.3_Missense_Mutation_p.E87D|EXD2_uc010aqt.3_Missense_Mutation_p.E212D|EXD2_uc010tte.2_Missense_Mutation_p.E212D	NM_001193360	NP_060669	Q9NVH0	EXD2_HUMAN	Homo sapiens exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1, mRNA.	87					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CCCTCGCTGAGACTGTTTTGA	0.448000													18	37					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49659052	49659052	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr10:49659052C>G	uc001jgu.3	-	8	1465	c.1168G>C	c.(1168-1170)Gag>Cag	p.E390Q	ARHGAP22_uc001jgs.3_Missense_Mutation_p.E284Q|ARHGAP22_uc001jgt.3_Missense_Mutation_p.E374Q|ARHGAP22_uc010qgl.2_Missense_Mutation_p.E331Q|ARHGAP22_uc010qgm.2_Missense_Mutation_p.E380Q|ARHGAP22_uc001jgv.3_Missense_Mutation_p.E72Q|ARHGAP22_uc001jgr.3_Missense_Mutation_p.E91Q	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Homo sapiens Rho GTPase activating protein 22 (ARHGAP22), transcript variant 3, mRNA.	374					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTGGTGACCTCCTCGGAGCCC	0.731000													25	31					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49390815	49390815	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr12:49390815A>T	uc001rsv.1	-	1	1862	c.1844T>A	c.(1843-1845)gTg>gAg	p.V615E		NM_015086	NP_055901	O94850	DEND_HUMAN	Homo sapiens dendrin (DDN), mRNA.	615	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						GATACGGGACACGGCTTCTCG	0.721000													11	14					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:49395482G>C	uc021wxw.1	-	0	310	c.230C>G	c.(229-231)cCg>cGg	p.P77R	GPX1_uc021wxx.1_Missense_Mutation_p.P77R	NM_000581	NP_000572	P07203	GPX1_HUMAN	Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 1, mRNA.	77					UV protection|anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion	cytosol|mitochondrion	SH3 domain binding|endopeptidase inhibitor activity|glutathione peroxidase activity			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.726000													4	92					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	170002334	170002334	+	Silent	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:170002334T>C	uc003fgs.2	+	11	1391	c.1153T>C	c.(1153-1155)Tta>Cta	p.L385L		NM_002740	NP_002731	P41743	KPCI_HUMAN	Homo sapiens protein kinase C, iota (PRKCI), mRNA.	385	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GGACAATGTATTACTGGACTC	0.338000													373	286					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112026372	112026372	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:112026372G>T	uc001ebf.3	-	5	1748	c.981C>A	c.(979-981)aaC>aaA	p.N327K	ADORA3_uc001ebg.4_Missense_Mutation_p.N246K	NM_020683	NP_065734	P33765	AA3R_HUMAN	Homo sapiens adenosine A3 receptor (ADORA3), transcript variant 1, mRNA.	0					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GCTTCAAAGTGTTGCCTACTT	0.418000													4	88					1.23904e-05	1.28177e-05	1	1	0
PASK	23178	broad.mit.edu	37	2	242082279	242082279	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:242082279G>T	uc002wao.2	-	1	302	c.169C>A	c.(169-171)Ctc>Atc	p.L57I	PASK_uc010zol.2_Missense_Mutation_p.D5E|PASK_uc010zom.2_Missense_Mutation_p.L57I|PASK_uc010fzl.2_Missense_Mutation_p.L57I|PASK_uc010zon.2_Intron|PASK_uc021vzf.1_Missense_Mutation_p.L57I|PASK_uc002waq.3_Missense_Mutation_p.L57I	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	Homo sapiens PAS domain containing serine/threonine kinase (PASK), transcript variant 2, mRNA.	57					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CTCTGGCAGAGTCTGGAAAGC	0.562000													27	22					3.73988e-18	4.15543e-18	1	1	0
PLIN3	10226	broad.mit.edu	37	19	4844785	4844785	+	Silent	SNP	G	G	A	rs34558416	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:4844785G>A	uc002mbj.2	-	6	1032	c.855C>T	c.(853-855)ggC>ggT	p.G285G	PLIN3_uc002mbk.2_Silent_p.G273G|PLIN3_uc002mbl.3_Silent_p.G285G	NM_005817	NP_005808	O60664	PLIN3_HUMAN	Homo sapiens perilipin 3 (PLIN3), transcript variant 1, mRNA.	285					vesicle-mediated transport	Golgi apparatus|endosome membrane|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTGATCAACGCCTTGCTTGA	0.597000													15	28					0	0	1	0	0
NT5C3	51251	broad.mit.edu	37	7	33054362	33054362	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:33054362T>C	uc003tdk.3	-	8	1068	c.991A>G	c.(991-993)Att>Gtt	p.I331V	AVL9_uc011kai.2_Intron|NT5C3_uc022abo.1_Missense_Mutation_p.I280V|NT5C3_uc003tdi.3_Missense_Mutation_p.I292V|NT5C3_uc003tdj.3_Missense_Mutation_p.I292V	NM_001002010	NP_001159590	Q9H0P0	5NT3_HUMAN	Homo sapiens 5'-nucleotidase, cytosolic III (NT5C3), transcript variant 1, mRNA.	331					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14			GBM - Glioblastoma multiforme(11;0.0894)			TTCTGTAAAATAGAGTTGGCT	0.358000													20	110					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31175075	31175075	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:31175075A>T	uc001wqm.1	+	17	1561	c.1537A>T	c.(1537-1539)Acc>Tcc	p.T513S	SCFD1_uc001wqn.1_Missense_Mutation_p.T446S|SCFD1_uc010tpg.1_Missense_Mutation_p.T454S|SCFD1_uc010tph.1_Missense_Mutation_p.T328S|SCFD1_uc010amf.1_Missense_Mutation_p.T328S|SCFD1_uc010tpi.1_Missense_Mutation_p.T421S|SCFD1_uc010amd.1_Missense_Mutation_p.T345S	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	Homo sapiens sec1 family domain containing 1 (SCFD1), transcript variant 1, mRNA.	513					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	Golgi cisterna membrane|Golgi-associated vesicle|cis-Golgi network|endoplasmic reticulum membrane|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TGGCAGCACTACCACTAAACC	0.373000													20	41					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91403569	91403569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:91403569G>T	uc001dnw.3	-	3	3444	c.3161C>A	c.(3160-3162)tCa>tAa	p.S1054*	ZNF644_uc001dnv.3_Intron|ZNF644_uc001dnx.3_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA.	1054					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AACATGATTTGATAATCCAAT	0.363000													14	21					1.05317e-09	1.13856e-09	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184765172	184765172	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:184765172G>A	uc001gra.3	-	13	1920	c.1726C>T	c.(1726-1728)Ccc>Tcc	p.P576S	FAM129A_uc001grb.1_Missense_Mutation_p.P339S	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	Homo sapiens family with sequence similarity 129, member A (FAM129A), transcript variant 2, mRNA.	576					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						CTTTCACTGGGCAAGGCCATG	0.443000													5	20					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39932148	39932148	+	Silent	SNP	A	A	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chrX:39932148A>G	uc004den.4	-	3	2743	c.2451T>C	c.(2449-2451)acT>acC	p.T817T	BCOR_uc004dep.4_Silent_p.T817T|BCOR_uc004deo.4_Silent_p.T817T|BCOR_uc004dem.4_Silent_p.T817T|BCOR_uc004deq.4_Silent_p.T817T	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	Homo sapiens BCL6 corepressor (BCOR), transcript variant 5, mRNA.	817					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						CGTTTGTGTCAGTTTTAGCAT	0.547000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						34	32					0	0	1	0	0
ULK3	25989	broad.mit.edu	37	15	75132623	75132623	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr15:75132623C>T	uc010ulq.1	-	5	684	c.681G>A	c.(679-681)agG>agA	p.R227R	ULK3_uc010ulp.1_Silent_p.R126R|ULK3_uc010ulr.1_Silent_p.R99R|ULK3_uc010bkf.1_Silent_p.R216R|ULK3_uc002ayv.2_Silent_p.R216R|ULK3_uc010uls.1_Silent_p.R99R|ULK3_uc010ult.1_3'UTR|ULK3_uc010ulu.1_3'UTR	NM_001099436	NP_001092906	Q6PHR2	ULK3_HUMAN	Homo sapiens unc-51-like kinase 3 (C. elegans) (ULK3), mRNA.	216	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						CCGAGAACGACCTGGAGGCAA	0.652000													14	20					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48809814	48809814	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr8:48809814C>G	uc003xqi.3	-	29	3562	c.3505G>C	c.(3505-3507)Gtc>Ctc	p.V1169L	PRKDC_uc003xqj.3_Missense_Mutation_p.V1169L	NM_006904	NP_008835	P78527	PRKDC_HUMAN	Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1, mRNA.	1169					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGCCACTTGACCAGATCCAAT	0.438000								Non-homologous end-joining					26	37					0	0	1	0	0
C14orf101	54916	broad.mit.edu	37	14	57072352	57072352	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:57072352A>C	uc001xcm.3	+	4	709	c.587A>C	c.(586-588)tAt>tCt	p.Y196S	C14orf101_uc001xcj.3_Non-coding_Transcript|C14orf101_uc001xck.3_Missense_Mutation_p.Y196S|C14orf101_uc010aot.1_Missense_Mutation_p.Y196S|C14orf101_uc001xcl.1_Non-coding_Transcript|C14orf101_uc001xcn.3_Non-coding_Transcript|C14orf101_uc010trf.2_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	Homo sapiens chromosome 14 open reading frame 101 (C14orf101), mRNA.	196						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(311;0.226)		ATAATACTCTATGTTTTGTGC	0.264000													32	62					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50387799	50387799	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:50387799G>A	uc002pqo.3	+	11	1626	c.1327G>A	c.(1327-1329)Ggc>Agc	p.G443S	TBC1D17_uc010ybg.2_Missense_Mutation_p.G410S|TBC1D17_uc002pqp.3_Missense_Mutation_p.G94S|TBC1D17_uc002pqr.3_Missense_Mutation_p.G94S	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	Homo sapiens TBC1 domain family, member 17 (TBC1D17), transcript variant 1, mRNA.	443	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GTGTTTCTGTGGCTTCATGGA	0.592000													34	70					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569322	53569322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr8:53569322G>A	uc003xre.4	-	14	3625	c.3067C>T	c.(3067-3069)Caa>Taa	p.Q1023*	RB1CC1_uc003xrf.4_Nonsense_Mutation_p.Q1023*	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Homo sapiens RB1-inducible coiled-coil 1 (RB1CC1), transcript variant 1, mRNA.	1023					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ULK1-ATG13-FIP200 complex|cytosol|nucleus|pre-autophagosomal structure	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TTAATTATTTGTTGGTTTTCC	0.343000													24	71					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45211204	45211204	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:45211204G>A	uc010xxd.2	+	5	1218	c.1012G>A	c.(1012-1014)Gtg>Atg	p.V338M		NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16), mRNA.	338										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				AACACTGACCGTGCAGGGCTA	0.672000													22	52					0	0	1	0	0
RPL19	6143	broad.mit.edu	37	17	37358657	37358657	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:37358657C>T	uc002hrq.1	+	2	262	c.200C>T	c.(199-201)aCc>aTc	p.T67I		NM_000981	NP_000972	P84098	RL19_HUMAN	Homo sapiens ribosomal protein L19 (RPL19), mRNA.	67					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7						CGGAAAAACACCTTGGCCCGC	0.522000													42	43					0	0	1	0	0
KIAA2012	0	broad.mit.edu	37	2	202939695	202939695	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:202939695T>A	uc010zhu.1	+	1	539	c.166T>A	c.(166-168)Tgg>Agg	p.W56R	KIAA2012_uc010ftp.2_Missense_Mutation_p.W56R					SubName: Full=cDNA FLJ52575;																		TCAGCACTCCTGGAGCCTCTT	0.483000													32	119					0	0	1	0	0
VASN	114990	broad.mit.edu	37	16	4432543	4432543	+	Silent	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr16:4432543A>C	uc021tch.1	+	0	1665	c.1665A>C	c.(1663-1665)acA>acC	p.T555T	CORO7-PAM16_uc002cwe.3_Intron|CORO7-PAM16_uc002cwf.3_Intron|CORO7-PAM16_uc002cwg.4_Intron|CORO7-PAM16_uc002cwh.4_Intron|CORO7-PAM16_uc010uxh.2_Intron|CORO7-PAM16_uc010uxi.2_Intron|CORO7-PAM16_uc002cwi.1_Intron|CORO7-PAM16_uc010uxj.1_Intron|CORO7-PAM16_uc010btp.1_Intron|VASN_uc002cwj.1_Silent_p.T555T	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	Homo sapiens vasorin (VASN), mRNA.	555	Fibronectin type-III.					extracellular region|integral to membrane				breast(1)|lung(3)|prostate(1)|skin(1)	6						AGGCCCATACACCCCCAGCCG	0.731000													5	43					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38506175	38506175	+	Splice_Site	SNP	A	A	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr5:38506175A>C	uc010ive.1	-	9	1454	c.1122_splice	c.e9-1	p.S374_splice	LIFR_uc003jli.2_Splice_Site_p.S374_splice	NM_001127671	NP_002301	P42702	LIFR_HUMAN	Homo sapiens leukemia inhibitory factor receptor alpha (LIFR), transcript variant 1, mRNA.	374	Fibronectin type-III 2.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TTTCCTGAAAAACTGTTAATT	0.254000			T	PLAG1	salivary adenoma								78	159					0	0	1	0	0
RAB31	11031	broad.mit.edu	37	18	9815181	9815181	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr18:9815181G>T	uc002kog.2	+	4	517	c.342G>T	c.(340-342)atG>atT	p.M114I		NM_006868	NP_006859	Q13636	RAB31_HUMAN	Homo sapiens RAB31, member RAS oncogene family (RAB31), mRNA.	113					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(3)|skin(1)	10						ACATTGTAATGGCCATCGCTG	0.403000													3	69					0.150653	0.151919	1	1	0
RFX1	5989	broad.mit.edu	37	19	14080923	14080923	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr19:14080923T>C	uc002mxv.3	-	9	1651	c.1379A>G	c.(1378-1380)tAc>tGc	p.Y460C	RFX1_uc010dzi.2_Missense_Mutation_p.Y460C	NM_002918	NP_002909	P22670	RFX1_HUMAN	Homo sapiens regulatory factor X, 1 (influences HLA class II expression) (RFX1), mRNA.	460					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GTAGTGGCAGTAGAGGGTGCT	0.627000													3	88					0	0	1	0	0
RMND5A	64795	broad.mit.edu	37	2	86947925	86947925	+	Silent	SNP	G	G	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:86947925G>A	uc002srr.2	+	0	512	c.135G>A	c.(133-135)caG>caA	p.Q45Q	RMND5A_uc002srs.4_5'UTR|RNF103_uc010ytl.2_Intron	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae) (RMND5A), mRNA.	45										kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						AGATCCTGCAGAGCCACGGTA	0.726000													19	26					0	0	1	0	0
C14orf43	91748	broad.mit.edu	37	14	74206660	74206660	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:74206660A>T	uc010tud.1	-	0	299	c.52T>A	c.(52-54)Ttc>Atc	p.F18I	C14orf43_uc001xot.3_Missense_Mutation_p.F18I|C14orf43_uc001xou.3_Missense_Mutation_p.F18I|C14orf43_uc010arw.2_Non-coding_Transcript	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	Homo sapiens chromosome 14 open reading frame 43 (C14orf43), transcript variant 1, mRNA.	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(4)	37				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		TGGCCCCCGAAGAGGCAACGC	0.652000													14	23					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944059	74944059	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:74944059G>T	uc002jti.3	+	14	2201	c.2098G>T	c.(2098-2100)Gcc>Tcc	p.A700S	MGAT5B_uc002jth.3_Missense_Mutation_p.A689S|MGAT5B_uc002jtj.3_Missense_Mutation_p.A96S	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B), transcript variant 2, mRNA.	691						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGCCCTGCGGGCCTGGCTGGC	0.701000													6	32					2.7689e-08	2.94042e-08	1	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68252617	68252617	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr14:68252617C>T	uc001xka.2	-	17	3401	c.3262G>A	c.(3262-3264)Gat>Aat	p.D1088N	ZFYVE26_uc010tsz.1_Non-coding_Transcript|ZFYVE26_uc001xkc.4_Missense_Mutation_p.D1088N	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	Homo sapiens zinc finger, FYVE domain containing 26 (ZFYVE26), mRNA.	1088					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGGACCTGATCTAGCTGCTGG	0.557000													24	49					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2066777	2066777	+	Silent	SNP	C	C	T			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:2066777C>T	uc001aiq.3	+	4	572	c.411C>T	c.(409-411)cgC>cgT	p.R137R	PRKCZ_uc001air.3_5'UTR|PRKCZ_uc010nyw.2_Silent_p.R33R|PRKCZ_uc001ais.3_5'UTR	NM_002744	NP_001028754	Q05513	KPCZ_HUMAN	Homo sapiens protein kinase C, zeta (PRKCZ), transcript variant 1, mRNA.	137	Interaction with SQSTM1 (By similarity).				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		AAGCCAAGCGCTTTAACAGGG	0.552000													16	10					0	0	1	0	0
YIPF3	25844	broad.mit.edu	37	6	43483379	43483379	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr6:43483379delT	uc003ovl.2	-	2	532	c.349delA	c.(349-351)atcfs	p.I117fs	YIPF3_uc011dvk.2_Frame_Shift_Del_p.I82fs|POLR1C_uc003ovn.3_5'Flank|POLR1C_uc003ovo.2_5'Flank	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	Homo sapiens Yip1 domain family, member 3 (YIPF3), mRNA.	117					cell differentiation	integral to membrane|plasma membrane|transport vesicle				large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GGTCTGAGGATGTCGATGTTG	0.517													32	50	---	---	---	---					
OGDH	4967	broad.mit.edu	37	7	44747231	44747232	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr7:44747231_44747232insA	uc003tln.3	+	21	3006_3007	c.2847_2848insA	c.(2845-2850)cccaatfs	p.P949fs	OGDH_uc011kbx.2_Frame_Shift_Ins_p.P945fs|OGDH_uc011kby.2_Frame_Shift_Ins_p.P799fs|OGDH_uc003tlp.3_Frame_Shift_Ins_p.P960fs|OGDH_uc011kbz.2_Frame_Shift_Ins_p.P744fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	949					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	AGAAGTACCCCAATGCTGAGCT	0.574													38	64	---	---	---	---					
FOXN1	8456	broad.mit.edu	37	17	26851949	26851949	+	Frame_Shift_Del	DEL	C	C	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	9f1e35f9-8141-463b-a1b9-3fc7a83df607	g.chr17:26851949delC	uc010crm.3	+	2	750	c.552delC	c.(550-552)ctcfs	p.L184fs	FOXN1_uc002hbj.3_Frame_Shift_Del_p.L184fs	NM_003593	NP_003584	O15353	FOXN1_HUMAN	Homo sapiens forkhead box N1 (FOXN1), mRNA.	184					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					GTAACGGGCTCCCCTACCCCA	0.647													21	41	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115520223	115520224	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:115520223_115520224insA	uc001efr.3	+	27	2577_2578	c.2368_2369insA	c.(2368-2370)gaafs	p.E790fs	SYCP1_uc010owt.2_Non-coding_Transcript|SYCP1_uc001efq.3_Frame_Shift_Ins_p.E790fs|SYCP1_uc009wgw.3_Frame_Shift_Ins_p.E765fs	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	Homo sapiens synaptonemal complex protein 1 (SYCP1), mRNA.	790					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTAAAGAAAAAAAAGAC	0.252													7	375	---	---	---	---					
SPRR3	6707	broad.mit.edu	37	1	152975659	152975682	+	In_Frame_Del	DEL	GAGCCAGGCTGTACCAAGGTCCCT	GAGCCAGGCTGTACCAAGGTCCCT	-	rs67156933	byFrequency	TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:152975659_152975682delGAGCCAGGCTGTACCAAGGTCCCT	uc021ozo.1	+	0	163_186	c.163_186delGAGCCAGGCTGTACCAAGGTCCCT	c.(163-186)gagccaggctgtaccaaggtccctdel	p.EPGCTKVP95del	SPRR3_uc001fax.4_In_Frame_Del_p.EPGCTKVP95del|SPRR3_uc001faz.4_In_Frame_Del_p.EPGCTKVP95del|SPRR3_uc001fay.2_Splice_Site_p.K60_splice	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	Homo sapiens small proline-rich protein 3 (SPRR3), transcript variant 1, mRNA.	95	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity	p.E95G(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAGATTCCAGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGCT	0.562													13	84	---	---	---	---					
ZC3H11A	9877	broad.mit.edu	37	1	203787783	203787786	+	Frame_Shift_Del	DEL	GACA	GACA	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr1:203787783_203787786delGACA	uc001hac.3	+	5	756_759	c.140_143delGACA	c.(139-144)cgacagfs	p.R47fs	ZC3H11A_uc001had.3_Frame_Shift_Del_p.R47fs|ZC3H11A_uc001hae.3_Frame_Shift_Del_p.R47fs|ZC3H11A_uc001haf.3_Frame_Shift_Del_p.R47fs|ZC3H11A_uc010pqm.2_5'UTR|ZC3H11A_uc001hag.1_Frame_Shift_Del_p.R47fs	NM_014827	NP_055642	O75152	ZC11A_HUMAN	Homo sapiens zinc finger CCCH-type containing 11A (ZC3H11A), mRNA.	47							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGCTGTTTTCGACAGGTGTGCAGG	0.426													29	56	---	---	---	---					
FOXN2	3344	broad.mit.edu	37	2	48573666	48573667	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:48573666_48573667insA	uc002rwh.1	+	2	628_629	c.313_314insA	c.(313-315)gaafs	p.E105fs		NM_002158	NP_002149	P32314	FOXN2_HUMAN	Homo sapiens forkhead box N2 (FOXN2), mRNA.	105					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			CCAGAACCCAGAAAAAAAATCA	0.431													7	199	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:96992793_96992795delGAG	uc002svy.3	+	0	859_861	c.448_450delGAG	c.(448-450)gagdel	p.E155del	ITPRIPL1_uc002svx.3_In_Frame_Del_p.E147del|ITPRIPL1_uc010yuk.2_In_Frame_Del_p.E139del|ITPRIPL1_uc010yul.2_In_Frame_Del_p.E139del	NM_178495	NP_001156996	Q6GPH6	IPIL1_HUMAN	Homo sapiens inositol 1,4,5-trisphosphate receptor interacting protein-like 1 (ITPRIPL1), transcript variant 1, mRNA.	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													8	125	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168106686	168106687	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr2:168106686_168106687delCT	uc002udx.3	+	8	8873_8874	c.8784_8785delCT	c.(8782-8787)tcctctfs	p.S2928fs	XIRP2_uc010fpn.3_Intron|XIRP2_uc010fpo.3_Intron|XIRP2_uc002udy.3_Frame_Shift_Del_p.S2753fs|XIRP2_uc010fpq.3_Frame_Shift_Del_p.S2706fs|XIRP2_uc010fpr.3_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	Homo sapiens xin actin-binding repeat containing 2 (XIRP2), transcript variant 1, mRNA.	2753					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTTTCTTTTCCTCTGTGAAAGA	0.371													207	229	---	---	---	---					
CELSR3	1951	broad.mit.edu	37	3	48692765	48692765	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr3:48692765delT	uc003cuf.1	-	6	5014	c.5014delA	c.(5014-5016)acafs	p.T1672fs	CELSR3_uc003cul.3_Frame_Shift_Del_p.T1602fs	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) (CELSR3), mRNA.	1602	Laminin G-like 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|calcium ion binding|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGATGCACTGTATGCCATTGC	0.582													26	48	---	---	---	---					
YIPF3	25844	broad.mit.edu	37	6	43483379	43483379	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr6:43483379delT	uc003ovl.2	-	2	532	c.349delA	c.(349-351)atcfs	p.I117fs	YIPF3_uc011dvk.2_Frame_Shift_Del_p.I82fs|POLR1C_uc003ovn.3_5'Flank|POLR1C_uc003ovo.2_5'Flank	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	Homo sapiens Yip1 domain family, member 3 (YIPF3), mRNA.	117					cell differentiation	integral to membrane|plasma membrane|transport vesicle				large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GGTCTGAGGATGTCGATGTTG	0.517													32	50	---	---	---	---					
OGDH	4967	broad.mit.edu	37	7	44747231	44747232	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr7:44747231_44747232insA	uc003tln.3	+	21	3006_3007	c.2847_2848insA	c.(2845-2850)cccaatfs	p.P949fs	OGDH_uc011kbx.2_Frame_Shift_Ins_p.P945fs|OGDH_uc011kby.2_Frame_Shift_Ins_p.P799fs|OGDH_uc003tlp.3_Frame_Shift_Ins_p.P960fs|OGDH_uc011kbz.2_Frame_Shift_Ins_p.P744fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	949					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	AGAAGTACCCCAATGCTGAGCT	0.574													38	64	---	---	---	---					
ESCO2	157570	broad.mit.edu	37	8	27634576	27634577	+	Frame_Shift_Ins	INS	-	-	A	rs80359854		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr8:27634576_27634577insA	uc003xgg.3	+	2	834_835	c.751_752insA	c.(751-753)gaafs	p.E251fs	ESCO2_uc010luy.1_Non-coding_Transcript|ESCO2_uc003xgh.3_Frame_Shift_Ins_p.E251fs	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	Homo sapiens establishment of cohesion 1 homolog 2 (S. cerevisiae) (ESCO2), mRNA.	251					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		GACTGTCAGTGAAAAAAAAACT	0.396									SC Phocomelia syndrome				8	168	---	---	---	---					
ATP2B1	490	broad.mit.edu	37	12	89992987	89992988	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr12:89992987_89992988insAA	uc001tbh.3	-	18	3438_3439	c.3257_3258insTT	c.(3256-3258)ttafs	p.L1086fs	ATP2B1_uc001tbg.3_Frame_Shift_Ins_p.L1086fs|ATP2B1_uc009zsr.3_Non-coding_Transcript|ATP2B1_uc001tbf.3_Frame_Shift_Ins_p.L720fs	NM_001682	NP_001673	P20020	AT2B1_HUMAN	Homo sapiens ATPase, Ca++ transporting, plasma membrane 1 (ATP2B1), transcript variant 2, mRNA.	1086					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						CATCCTCTGCTAATTCCTCCTC	0.436													41	42	---	---	---	---					
TSC22D1	8848	broad.mit.edu	37	13	45148706	45148708	+	In_Frame_Del	DEL	TGC	TGC	-	rs112613609		TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr13:45148706_45148708delTGC	uc001uzn.4	-	0	1994_1996	c.1503_1505delGCA	c.(1501-1506)cagcaa>caa	p.501_502QQ>Q	TSC22D1_uc001uzo.2_In_Frame_Del_p.501_502QQ>Q|TSC22D1-AS1_uc021rjb.1_5'Flank	NM_183422	NP_904358	Q15714	T22D1_HUMAN	Homo sapiens TSC22 domain family, member 1 (TSC22D1), transcript variant 1, mRNA.	501	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ttgttgttgttgctgctgctgct	0.507													7	55	---	---	---	---					
THSD1	55901	broad.mit.edu	37	13	52971551	52971551	+	Frame_Shift_Del	DEL	G	G	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr13:52971551delG	uc001vgo.3	-	2	1382	c.837delC	c.(835-837)cccfs	p.P279fs	THSD1_uc001vgp.3_Frame_Shift_Del_p.P279fs|THSD1_uc010tgz.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	Homo sapiens thrombospondin, type I, domain containing 1 (THSD1), transcript variant 1, mRNA.	279						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CAGGGTATCTGGGGGCCTCCT	0.537													43	74	---	---	---	---					
FOXN1	8456	broad.mit.edu	37	17	26851949	26851949	+	Frame_Shift_Del	DEL	C	C	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr17:26851949delC	uc010crm.3	+	2	750	c.552delC	c.(550-552)ctcfs	p.L184fs	FOXN1_uc002hbj.3_Frame_Shift_Del_p.L184fs	NM_003593	NP_003584	O15353	FOXN1_HUMAN	Homo sapiens forkhead box N1 (FOXN1), mRNA.	184					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					GTAACGGGCTCCCCTACCCCA	0.647													21	41	---	---	---	---					
CST9L	128821	broad.mit.edu	37	20	23546668	23546670	+	In_Frame_Del	DEL	CCC	CCC	-			TCGA-A4-A5XZ-01A-11D-A31X-10	TCGA-A4-A5XZ-11A-11D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	363096af-a78b-4834-a631-bebac9ce1659	a7fd93bf-bde1-4b31-a98b-886f0d032211	g.chr20:23546668_23546670delCCC	uc002wtk.4	-	1	594_596	c.295_297delGGG	c.(295-297)gggdel	p.G99del		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	Homo sapiens cystatin 9-like (CST9L), mRNA.	99						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CTTCAAATTTCCCACACCTAGTT	0.473													64	87	---	---	---	---					
