Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DYX1C1	161582	broad.mit.edu	37	15	55731768	55731768	+	Silent	SNP	T	T	C			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr15:55731768T>C	uc002adc.3	-	6	1163	c.795A>G	c.(793-795)aaA>aaG	p.K265K	CCPG1_uc002acy.3_5'UTR|CCPG1_uc010ugh.1_Non-coding_Transcript|CCPG1_uc010ugi.2_Non-coding_Transcript|DYX1C1_uc002adb.3_Silent_p.K265K|DYX1C1_uc002add.3_Silent_p.K265K	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	Homo sapiens dyslexia susceptibility 1 candidate 1 (DYX1C1), transcript variant 1, mRNA.	265					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		CCTCAGCTTGTTTGTGTAGCC	0.348000													19	57					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520965	153520965	+	Splice_Site	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr1:153520965C>T	uc001fca.1	-	2	79	c.-4_splice	c.e2-1		S100A4_uc001fby.3_5'Flank|S100A4_uc001fbz.3_5'Flank|AK307246_uc009wog.1_Non-coding_Transcript	NM_002960	NP_002951	P33764	S10A3_HUMAN	Homo sapiens S100 calcium binding protein A3 (S100A3), mRNA.								calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGCCATCCTCACTGTCACAG	0.607000													12	56					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996146	140996146	+	Missense_Mutation	SNP	G	G	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chrX:140996146G>T	uc004fbt.3	+	3	3280	c.2956G>T	c.(2956-2958)Ggg>Tgg	p.G986W	MAGEC1_uc010nsl.2_Missense_Mutation_p.G53W|MAGEC1_uc022cfi.1_Missense_Mutation_p.G645W	NM_005462	NP_005453	O60732	MAGC1_HUMAN	Homo sapiens melanoma antigen family C, 1 (MAGEC1), mRNA.	986	MAGE.						protein binding	p.E985Q(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CACCTCTGAGGGGTGTCTGAG	0.478000										HNSCC(15;0.026)			38	89					2.40579e-17	2.71765e-17	1	1	0
ZC3H6	376940	broad.mit.edu	37	2	113079400	113079400	+	Silent	SNP	C	C	G			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:113079400C>G	uc002thq.1	+	7	1438	c.1044C>G	c.(1042-1044)tcC>tcG	p.S348S		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	Homo sapiens zinc finger CCCH-type containing 6 (ZC3H6), mRNA.	348							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GTAAATTTTCCCATGATGATC	0.308000													39	85					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106845237	106845237	+	Missense_Mutation	SNP	G	G	C			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chrX:106845237G>C	uc022cce.1	+	0	1603	c.1235G>C	c.(1234-1236)aGg>aCg	p.R412T				Q5JV73	FRPD3_HUMAN	Homo sapiens mRNA for KIAA1817 protein, partial cds.	1356	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CTCCGGGGGAGGGAAAGGGAC	0.672000													4	34					0	0	1	0	0
C11orf45	219833	broad.mit.edu	37	11	128772504	128772504	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr11:128772504C>T	uc001qeu.3	-	3	580	c.386G>A	c.(385-387)cGc>cAc	p.R129H	KCNJ5_uc001qet.3_Intron|KCNJ5_uc009zck.3_Intron|C11orf45_uc009zcl.3_Missense_Mutation_p.R129H|C11orf45_uc001qev.3_Missense_Mutation_p.R129H	NM_145013	NP_659450	Q8TAV5	CK045_HUMAN	Homo sapiens chromosome 11 open reading frame 45 (C11orf45), transcript variant 2, mRNA.	129						extracellular region				endometrium(1)|kidney(1)|lung(2)|pancreas(1)|prostate(2)	7	all_hematologic(175;0.0641)	Lung NSC(97;0.00521)|Breast(109;0.00715)|all_lung(97;0.0111)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.00531)|LUSC - Lung squamous cell carcinoma(976;0.0193)|Lung(977;0.0195)		GTAGCCCAGGCGGCCCTCTCT	0.607000													23	30					0	0	1	0	0
BIK	638	broad.mit.edu	37	22	43523734	43523734	+	Missense_Mutation	SNP	G	G	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr22:43523734G>T	uc003bdk.3	+	2	256	c.193G>T	c.(193-195)Ggg>Tgg	p.G65W		NM_001197	NP_001188	Q13323	BIK_HUMAN	Homo sapiens BCL2-interacting killer (apoptosis-inducing) (BIK), mRNA.	65					apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane				breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|urinary_tract(1)	5		Ovarian(80;0.0694)				GGCCTGCATCGGGGACGAGAT	0.677000													8	31					0.000442599	0.000457603	1	1	0
MYCN	4613	broad.mit.edu	37	2	16085781	16085781	+	Silent	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:16085781C>T	uc002rci.3	+	2	1257	c.957C>T	c.(955-957)atC>atT	p.I319I	MYCN_uc010yjr.2_Silent_p.I319I	NM_005378	NP_005369	P04198	MYCN_HUMAN	Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN), mRNA.	319					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.L318L(1)		NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GCGAGCTGATCCTCAAACGAT	0.592000			A		neuroblastoma								92	294					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869479	4869479	+	Silent	SNP	A	A	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr11:4869479A>T	uc010qyo.2	-	0	960	c.960T>A	c.(958-960)ggT>ggA	p.G320G		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily S, member 1 (OR51S1), mRNA.	320					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGAGCACCACCCACCTTCC	0.448000													20	75					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151532942	151532942	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chrX:151532942C>T	uc010ntk.1	-	1	341	c.101G>A	c.(100-102)cGa>cAa	p.R34Q		NM_000808	NP_000799	P34903	GBRA3_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 3 (GABRA3), mRNA.	34					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|protein binding	p.R34*(2)		breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGGTTCTTGTCGTCTTGATTC	0.443000													40	50					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51994252	51994252	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr3:51994252C>T	uc003dcc.2	-	3	959	c.238G>A	c.(238-240)Ggc>Agc	p.G80S	PCBP4_uc003dcb.2_Missense_Mutation_p.G80S|PCBP4_uc003dcf.2_Missense_Mutation_p.G114S|PCBP4_uc003dce.2_Missense_Mutation_p.G114S|PCBP4_uc003dcg.2_Missense_Mutation_p.G80S|PCBP4_uc003dcj.2_Missense_Mutation_p.G114S|PCBP4_uc003dck.2_Missense_Mutation_p.G114S|PCBP4_uc003dch.2_Missense_Mutation_p.G114S|PCBP4_uc003dci.2_Missense_Mutation_p.G37S			P57723	PCBP4_HUMAN	Homo sapiens poly(rC) binding protein 4 (PCBP4), transcript variant 4, mRNA.	114						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ATCAGTGAGCCACACTGACTG	0.587000													51	203					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36238386	36238386	+	Silent	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr6:36238386G>A	uc010jwf.2	+	0	150	c.150G>A	c.(148-150)gcG>gcA	p.A50A	PNPLA1_uc010jwe.1_Intron|PNPLA1_uc003olw.1_Intron	NM_001145717	NP_775947	Q8N8W4	PLPL1_HUMAN	Homo sapiens patatin-like phospholipase domain containing 1 (PNPLA1), transcript variant 3, mRNA.	50	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						ACCGCTTTGCGGGGACATCGG	0.652000													78	13					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142031582	142031582	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr3:142031582G>A	uc003eus.3	-	40	4743	c.4676C>T	c.(4675-4677)tCg>tTg	p.S1559L	XRN1_uc010huu.3_Missense_Mutation_p.S1013L|XRN1_uc003eut.3_Missense_Mutation_p.S1546L|XRN1_uc003euu.3_Missense_Mutation_p.S1547L	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	Homo sapiens 5'-3' exoribonuclease 1 (XRN1), transcript variant 1, mRNA.	1559					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	Golgi apparatus|cytosol|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|RNA binding|protein binding	p.S1558L(1)		NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						GAGATGAGACGACGAAGGCAT	0.443000													21	82					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67265386	67265386	+	Missense_Mutation	SNP	G	G	A	rs145700198	byFrequency	TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr16:67265386G>A	uc002esl.3	-	15	2564	c.2452C>T	c.(2452-2454)Cgc>Tgc	p.R818C	FHOD1_uc010ced.3_Missense_Mutation_p.R625C	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	Homo sapiens formin homology 2 domain containing 1 (FHOD1), mRNA.	818	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGGATGCAGCGGAAGGTGGCA	0.557000													7	236					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3425692	3425692	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr1:3425692G>A	uc001akl.3	-	11	1702	c.1475C>T	c.(1474-1476)gCc>gTc	p.A492V	MEGF6_uc001akk.3_Missense_Mutation_p.A387V	NM_001409	NP_001400	O75095	MEGF6_HUMAN	Homo sapiens multiple EGF-like-domains 6 (MEGF6), mRNA.	492						extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TTCCTCATCGGCCCCGACGTC	0.682000													7	26					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49135888	49135888	+	Missense_Mutation	SNP	A	A	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr3:49135888A>T	uc003cvx.3	-	20	1987	c.1982T>A	c.(1981-1983)cTg>cAg	p.L661Q	QARS_uc011bcc.2_Missense_Mutation_p.L114Q|QARS_uc011bcd.2_Missense_Mutation_p.L516Q|QARS_uc003cvy.3_Missense_Mutation_p.L516Q|QARS_uc011bce.2_Missense_Mutation_p.L650Q	NM_005051	NP_005042	P47897	SYQ_HUMAN	Homo sapiens glutaminyl-tRNA synthetase (QARS), mRNA.	661					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GGTCACCTCCAGACTCTCTAC	0.562000													29	69					0	0	1	0	0
GFM2	84340	broad.mit.edu	37	5	74018240	74018240	+	Missense_Mutation	SNP	T	T	G			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr5:74018240T>G	uc010izj.1	-	20	2597	c.2271A>C	c.(2269-2271)aaA>aaC	p.K757N	GFM2_uc003kdh.1_Missense_Mutation_p.K725N|GFM2_uc003kdi.1_Missense_Mutation_p.K678N|GFM2_uc010izk.1_Non-coding_Transcript	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	Homo sapiens G elongation factor, mitochondrial 2 (GFM2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	725					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(5)|prostate(1)	14		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		CAATAACAACTTTGTTGTCCT	0.388000													5	72					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18478009	18478009	+	Silent	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr12:18478009C>T	uc001rdt.3	+	7	1365	c.1249C>T	c.(1249-1251)Ctg>Ttg	p.L417L	PIK3C2G_uc010sia.2_Non-coding_Transcript|PIK3C2G_uc010sib.2_Silent_p.L417L|PIK3C2G_uc010sic.2_Silent_p.L195L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	Homo sapiens phosphoinositide-3-kinase, class 2, gamma polypeptide (PIK3C2G), mRNA.	417					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TGACTTCCACCTGAAATACCT	0.299000													10	13					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13002761	13002761	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr19:13002761C>T	uc002mvq.3	+	3	321	c.244C>T	c.(244-246)Cgc>Tgc	p.R82C	GCDH_uc010xms.2_Missense_Mutation_p.R70C|GCDH_uc002mvp.3_Missense_Mutation_p.R82C|GCDH_uc010xmt.2_5'UTR|GCDH_uc010xmu.2_Silent_p.L19L	NM_000159	NP_000150	Q92947	GCDH_HUMAN	Homo sapiens glutaryl-CoA dehydrogenase (GCDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	82					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						ACTCATGCCTCGCATCCTGTT	0.637000													19	100					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4164162	4164162	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr16:4164162G>A	uc002cvx.3	-	1	1821	c.1282C>T	c.(1282-1284)Cgc>Tgc	p.R428C		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	428	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TCACACAGGCGGTCGAAGCGA	0.572000													19	87					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90263622	90263622	+	Missense_Mutation	SNP	C	C	T	rs148876094	byFrequency	TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr14:90263622C>T	uc001xxt.3	-	5	542	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	EFCAB11_uc001xxs.3_Missense_Mutation_p.E129K	NM_145231	NP_660274	Q9BUY7	EFC11_HUMAN	Homo sapiens EF-hand calcium binding domain 11 (EFCAB11), mRNA.	153	EF-hand 3.						calcium ion binding	p.E153G(1)		large_intestine(1)|lung(1)	2						AGGGCATATTCAAAGTCTCTA	0.393000													3	63					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651490	7651490	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr12:7651490G>A	uc001qsz.3	-	3	880	c.752C>T	c.(751-753)gCt>gTt	p.A251V	CD163_uc001qta.3_Missense_Mutation_p.A251V|CD163_uc009zfw.2_Missense_Mutation_p.A251V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	Homo sapiens CD163 molecule (CD163), transcript variant 1, mRNA.	251	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGCATCCTCAGCATGATCACA	0.433000													20	76					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58541744	58541744	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr16:58541744C>T	uc002enm.3	+	10	1150	c.809C>T	c.(808-810)aCg>aTg	p.T270M	NDRG4_uc002enk.3_Missense_Mutation_p.T250M|NDRG4_uc010vif.2_Missense_Mutation_p.T250M|NDRG4_uc002eno.3_Missense_Mutation_p.T218M|NDRG4_uc010cdk.3_Missense_Mutation_p.T236M|NDRG4_uc010vig.2_Missense_Mutation_p.T248M|NDRG4_uc010vih.2_Missense_Mutation_p.T163M|NDRG4_uc010vii.2_Missense_Mutation_p.T236M|NDRG4_uc002enp.3_Missense_Mutation_p.T218M|NDRG4_uc002enq.1_Intron	NM_001130487	NP_075061	Q9ULP0	NDRG4_HUMAN	Homo sapiens NDRG family member 4 (NDRG4), transcript variant 2, mRNA.	218					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						CGGCCTGGAACGGTGCCCAAT	0.667000													13	77					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11129655	11129655	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr19:11129655G>A	uc010dxp.3	+	17	2821	c.2461G>A	c.(2461-2463)Gag>Aag	p.E821K	SMARCA4_uc010dxo.3_Missense_Mutation_p.E821K|SMARCA4_uc002mqf.4_Missense_Mutation_p.E821K|SMARCA4_uc002mqg.1_Missense_Mutation_p.E821K|SMARCA4_uc010dxq.3_Missense_Mutation_p.E821K|SMARCA4_uc010dxr.3_Missense_Mutation_p.E821K|SMARCA4_uc002mqj.4_Missense_Mutation_p.E821K|SMARCA4_uc010dxs.3_Missense_Mutation_p.E821K|SMARCA4_uc010dxt.1_Missense_Mutation_p.E41K|SMARCA4_uc002mqh.4_5'Flank|SMARCA4_uc002mqi.1_5'Flank	NM_001128844	NP_003063	P51532	SMCA4_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 2, mRNA.	821	Helicase ATP-binding.				chromatin remodeling|negative regulation of S phase of mitotic cell cycle|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|WINAC complex|nBAF complex|npBAF complex|nuclear chromatin	ATP binding|DNA binding|DNA-dependent ATPase activity|androgen receptor binding|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.E821K(6)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGGGCGTACGAGTTTGACAA	0.557000			"""F, N, Mis"""		NSCLC								160	55					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7894923	7894923	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr20:7894923G>A	uc002wmw.1	-	2	457	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	HAO1_uc010gbu.3_Missense_Mutation_p.R145W	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	Homo sapiens hydroxyacid oxidase (glycolate oxidase) 1 (HAO1), mRNA.	145	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TCTGCCTGCCGCACTAGCTTC	0.517000													62	194					0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151859226	151859226	+	Missense_Mutation	SNP	C	C	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr7:151859226C>A	uc003wla.3	-	42	11655	c.11436G>T	c.(11434-11436)gaG>gaT	p.E3812D	MLL3_uc003wkz.3_Missense_Mutation_p.E2873D|MLL3_uc003wky.3_Missense_Mutation_p.E1321D	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	3812					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGTTCTGCTTCTCAACTAGTT	0.328000			N		medulloblastoma								6	22					8.12818e-05	8.69858e-05	1	1	0
CRYGD	1421	broad.mit.edu	37	2	208988981	208988981	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:208988981G>A	uc002vcn.4	-	1	223	c.107C>T	c.(106-108)gCg>gTg	p.A36V	LOC100507443_uc021vvt.1_Intron|CRYGD_uc021vvu.1_Missense_Mutation_p.A36V	NM_006891	NP_008822	P07320	CRGD_HUMAN	Homo sapiens crystallin, gamma D (CRYGD), mRNA.	36	Beta/gamma crystallin 'Greek key' 1.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens			breast(1)|endometrium(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GTCCACGCGCGCCGAGTTGCA	0.652000													4	38					0	0	1	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217562	26217562	+	Silent	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr6:26217562G>A	uc003nha.1	+	0	415	c.360G>A	c.(358-360)aaG>aaA	p.K120K	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	Homo sapiens histone cluster 1, H2ae (HIST1H2AE), mRNA.	120					nucleosome assembly	nucleosome|nucleus	DNA binding	p.K120N(2)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				TGCCTAAGAAGACGGAGAGCC	0.542000													75	47					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12491639	12491639	+	Missense_Mutation	SNP	A	A	G	rs59301182	by1000genomes	TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr19:12491639A>G	uc002mts.4	-	3	957	c.437T>C	c.(436-438)cTg>cCg	p.L146P				Q96GE5	ZN799_HUMAN	Homo sapiens zinc finger protein 799 (ZNF799), mRNA.	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						ACATTCATACAGTTTCTCCCC	0.368000													3	55					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12491654	12491654	+	Missense_Mutation	SNP	C	C	T	rs57371898	by1000genomes	TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr19:12491654C>T	uc002mts.4	-	3	942	c.422G>A	c.(421-423)cGt>cAt	p.R141H				Q96GE5	ZN799_HUMAN	Homo sapiens zinc finger protein 799 (ZNF799), mRNA.	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						CTCCCCAGTACGTGTTCTTTC	0.373000													3	56					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44762365	44762365	+	Splice_Site	SNP	G	G	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr3:44762365G>T	uc011baa.2	+	4	311	c.56_splice	c.e4-1	p.G19_splice	ZNF502_uc003cns.3_Splice_Site_p.G19_splice|ZNF502_uc011bab.2_Splice_Site_p.G19_splice|ZNF502_uc003cnt.3_Splice_Site_p.G19_splice	NM_001134440	NP_149987	Q8TBZ5	ZN502_HUMAN	Homo sapiens zinc finger protein 502 (ZNF502), transcript variant 2, mRNA.	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TTTCTTTCAGGCTGGGTAAAC	0.443000													23	27					2.48779e-11	2.75919e-11	1	1	0
CLCN3	1182	broad.mit.edu	37	4	170625204	170625204	+	Missense_Mutation	SNP	T	T	C			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr4:170625204T>C	uc003ish.3	+	9	2178	c.1619T>C	c.(1618-1620)aTt>aCt	p.I540T	CLCN3_uc003isi.3_Missense_Mutation_p.I540T|CLCN3_uc011cka.2_Missense_Mutation_p.I513T|CLCN3_uc011cjz.2_Missense_Mutation_p.I523T|CLCN3_uc003isj.2_Missense_Mutation_p.I513T	NM_173872	NP_776297	P51790	CLCN3_HUMAN	Homo sapiens chloride channel 3 (CLCN3), transcript variant e, mRNA.	540					endosomal lumen acidification	Golgi membrane|cell surface|early endosome membrane|integral to membrane|late endosome membrane|transport vesicle membrane	ATP binding|PDZ domain binding|antiporter activity|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GCAGGAAGGATTGTGGGGATT	0.507000													51	122					0	0	1	0	0
KCNK9	51305	broad.mit.edu	37	8	140630623	140630623	+	Missense_Mutation	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr8:140630623C>T	uc003yvf.1	-	1	1067	c.1003G>A	c.(1003-1005)Gag>Aag	p.E335K	KCNK9_uc003yvg.1_Missense_Mutation_p.E335K|KCNK9_uc003yve.1_Non-coding_Transcript	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	Homo sapiens potassium channel, subfamily K, member 9 (KCNK9), mRNA.	335						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity	p.I334I(2)		NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GAGATCTCCTCGATCTTGTAA	0.552000													73	98					0	0	1	0	0
DNAAF2	55172	broad.mit.edu	37	14	50092296	50092296	+	Missense_Mutation	SNP	G	G	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr14:50092296G>T	uc001wws.4	-	2	2559	c.2478C>A	c.(2476-2478)ttC>ttA	p.F826L	NEMF_uc010anj.1_Intron|DNAAF2_uc001wwt.4_Missense_Mutation_p.F778L	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	Homo sapiens dynein, axonemal, assembly factor 2 (DNAAF2), transcript variant 1, mRNA.	826					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						TCTGAAAACTGAATGCACAAT	0.308000													16	45					4.96729e-08	5.4108e-08	1	1	0
HTR3C	170572	broad.mit.edu	37	3	183777668	183777668	+	Silent	SNP	C	C	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr3:183777668C>T	uc003fmk.3	+	7	1012	c.978C>T	c.(976-978)acC>acT	p.T326T		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member C (HTR3C), mRNA.	326						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGCTGGAGACCGTCTTCATTA	0.562000													22	76					0	0	1	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98206091	98206091	+	Missense_Mutation	SNP	G	G	T			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:98206091G>T	uc010yvc.1	-	0	338	c.58C>A	c.(58-60)Cat>Aat	p.H20N	ANKRD36B_uc010yve.1_Non-coding_Transcript|ANKRD36B_uc010fif.2_Non-coding_Transcript	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	Homo sapiens ankyrin repeat domain 36B (ANKRD36B), mRNA.	20																	CTCTTCAGATGATACGGTTTA	0.498000													66	228					1.49552e-23	1.72126e-23	1	1	0
RANBP2	5903	broad.mit.edu	37	2	109399079	109399079	+	Missense_Mutation	SNP	T	T	G			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:109399079T>G	uc002tem.4	+	27	9256	c.9130T>G	c.(9130-9132)Tta>Gta	p.L3044V		NM_006267	NP_006258	P49792	RBP2_HUMAN	Homo sapiens RAN binding protein 2 (RANBP2), mRNA.	3044	RanBD1 4.				carbohydrate metabolic process|glucose transport|mRNA transport|mitotic prometaphase|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	Ran GTPase binding|peptidyl-prolyl cis-trans isomerase activity|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TCAGCAGAATTTAATGAAACT	0.393000													18	55					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63720609	63720609	+	Missense_Mutation	SNP	C	C	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr7:63720609C>A	uc003tsx.3	+	2	319	c.50C>A	c.(49-51)aCa>aAa	p.T17K		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	Homo sapiens zinc finger protein 679 (ZNF679), mRNA.	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						GGACTGTTGACATTCAGAGAT	0.388000													9	113					0.000274275	0.000288462	1	1	0
ADCY9	115	broad.mit.edu	37	16	4163953	4163953	+	Silent	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr16:4163953G>A	uc002cvx.3	-	1	2030	c.1491C>T	c.(1489-1491)tgC>tgT	p.C497C		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	497	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCAGGATGCCGCAAAGGACGG	0.562000													116	45					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88913362	88913362	+	Silent	SNP	T	T	C			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr2:88913362T>C	uc002stc.4	-	1	620	c.318A>G	c.(316-318)gtA>gtG	p.V106V		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3), mRNA.	106					ER overload response|activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TGCTGATAATTACTAATGACC	0.373000													11	15					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135282924	135282924	+	Missense_Mutation	SNP	G	G	A			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr7:135282924G>A	uc003vsw.3	+	14	2274	c.2243G>A	c.(2242-2244)cGt>cAt	p.R748H		NM_015135	NP_055950	Q92621	NU205_HUMAN	Homo sapiens nucleoporin 205kDa (NUP205), mRNA.	748					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.R748S(1)		breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						CTACGATTCCGTACAAGAGCT	0.428000													28	54					0	0	1	0	0
ADAM9	8754	broad.mit.edu	37	8	38880792	38880793	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr8:38880792_38880793insG	uc003xmr.3	+	8	940_941	c.862_863insG	c.(862-864)cggfs	p.R288fs	ADAM9_uc010lwr.3_Non-coding_Transcript|ADAM9_uc011lcf.2_Non-coding_Transcript|ADAM9_uc011lcg.2_Non-coding_Transcript	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	Homo sapiens ADAM metallopeptidase domain 9 (ADAM9), transcript variant 1, mRNA.	288	Peptidase M12B.				PMA-inducible membrane protein ectodomain proteolysis|activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	SH3 domain binding|collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			CGTGCAGTGGCGGGAAAAGTTT	0.396													8	134	---	---	---	---					
DDX12P	440081	broad.mit.edu	37	12	9573305	9573305	+	RNA	DEL	G	G	-			TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr12:9573305delG	uc021qut.1	-	10		c.2093delC			DDX12P_uc001qvx.4_Intron|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.																		gagggagggagggagCCCCCA	0.582													10	35	---	---	---	---					
QRICH2	84074	broad.mit.edu	37	17	74288687	74288716	+	In_Frame_Del	DEL	CTGATCTGCACCAGGTTGCACCACATCAAT	CTGATCTGCACCAGGTTGCACCACATCAAT	-	rs140703547	by1000genomes	TCGA-AL-A5DJ-01A-11D-A26P-10	TCGA-AL-A5DJ-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4f515ce-5bee-4e40-a66a-01f41e92181e	7c64233c-871d-4df4-8c4d-d60713a4ac1e	g.chr17:74288687_74288716delCTGATCTGCACCAGGTTGCACCACATCAAT	uc002jrd.1	-	3	1774_1803	c.1594_1623delATTGATGTGGTGCAACCTGGTGCAGATCAG	c.(1594-1623)attgatgtggtgcaacctggtgcagatcagdel	p.IDVVQPGADQ532del	QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	Homo sapiens glutamine rich 2 (QRICH2), mRNA.	532	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CCAAACCATGCTGATCTGCACCAGGTTGCACCACATCAATCTGATCTGCA	0.526													105	241	---	---	---	---					
