Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ITGAM	3684	broad.mit.edu	37	16	31335987	31335987	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:31335987C>A	uc002ebr.3	+	17	2274	c.2176C>A	c.(2176-2178)Cca>Aca	p.P726T	ITGAM_uc002ebq.3_Missense_Mutation_p.P725T|ITGAM_uc010can.3_Missense_Mutation_p.P131T|ITGAM_uc002ebs.1_Missense_Mutation_p.P131T|ITGAM_uc010vfj.1_5'Flank	NM_001145808	NP_001139280	P11215	ITAM_HUMAN	Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 1, mRNA.	725					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity	p.V726L(1)		endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CATCGAGGACCCAGTGAGCCC	0.602000													16	109					1.15088e-07	1.31794e-07	1	1	0
NKX2-5	1482	broad.mit.edu	37	5	172659726	172659726	+	Missense_Mutation	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr5:172659726T>G	uc003mcm.2	-	1	1050	c.821A>C	c.(820-822)tAc>tCc	p.Y274S	NKX2-5_uc010jjt.2_3'UTR|NKX2-5_uc011dfe.2_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	Homo sapiens NK2 homeobox 5 (NKX2-5), transcript variant 1, mRNA.	274	Ala/Pro-rich.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)	12	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCCGGCGGGGTAAGCGGCAGT	0.677000													5	88					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187541450	187541450	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:187541450C>A	uc003izf.3	-	9	6478	c.6290G>T	c.(6289-6291)gGc>gTc	p.G2097V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	Homo sapiens FAT tumor suppressor homolog 1 (Drosophila) (FAT1), mRNA.	2097	Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AATGACATGGCCCACCTCAGT	0.468000										HNSCC(5;0.00058)			5	105					1	1	1	1	0
ANKRD36	375248	broad.mit.edu	37	2	97869958	97869958	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:97869958A>T	uc010yva.2	+	49	3263	c.3019A>T	c.(3019-3021)Aat>Tat	p.N1007Y	ANKRD36_uc002sxp.3_Non-coding_Transcript	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.	1007										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TTCTGTTTTGAATATAGCCAG	0.299000													4	73					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869971	97869971	+	Missense_Mutation	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:97869971G>A	uc010yva.2	+	49	3276	c.3032G>A	c.(3031-3033)gGa>gAa	p.G1011E	ANKRD36_uc002sxp.3_Non-coding_Transcript	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.	1011										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						ATAGCCAGAGGAAAAAAGGAT	0.308000													4	64					0	0	1	0	0
PVR	5817	broad.mit.edu	37	19	45162149	45162149	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:45162149C>T	uc002ozm.3	+	5	1430	c.1131C>T	c.(1129-1131)caC>caT	p.H377H	PVR_uc010ejs.3_Silent_p.H377H|PVR_uc010xxb.2_Intron|PVR_uc010xxc.2_Intron|PVR_uc002ozn.3_Silent_p.H322H	NM_006505	NP_006496	P15151	PVR_HUMAN	Homo sapiens poliovirus receptor (PVR), transcript variant 1, mRNA.	377					adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to T cell mediated cytotoxicity|susceptibility to natural killer cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TCCTTTGGCACTGTCATCTGT	0.512000													5	59					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153916546	153916546	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:153916546A>G	uc001fdd.1	-	1	706	c.305T>C	c.(304-306)cTc>cCc	p.L102P		NM_014856	NP_055671	O75064	DEN4B_HUMAN	Homo sapiens DENN/MADD domain containing 4B (DENND4B), mRNA.	102	MABP.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGCTCAACGAGGGGGGGCTT	0.632000													16	45					0	0	1	0	0
C18orf34	374864	broad.mit.edu	37	18	30992013	30992013	+	Missense_Mutation	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr18:30992013C>T	uc010xbr.1	-	1	182	c.40G>A	c.(40-42)Gat>Aat	p.D14N	C18orf34_uc002kxn.2_Missense_Mutation_p.D14N|C18orf34_uc010dmf.1_Missense_Mutation_p.D14N|C18orf34_uc002kxo.2_Missense_Mutation_p.D14N|C18orf34_uc002kxp.3_Missense_Mutation_p.D14N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	Homo sapiens chromosome 18 open reading frame 34 (C18orf34), transcript variant 1, mRNA.	14										NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|liver(1)|lung(36)|ovary(3)|pancreas(1)|prostate(2)|skin(2)	65						GTTTGATCATCTCTAGTGGAA	0.274000													124	235					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359427	66359427	+	Missense_Mutation	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:66359427C>T	uc001oiq.4	-	0	1128	c.1060G>A	c.(1060-1062)Gct>Act	p.A354T	CCS_uc001oir.3_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	Homo sapiens coiled-coil domain containing 87 (CCDC87), mRNA.	354										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AGATCCTCAGCCACGATGAGC	0.587000													27	38					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182922005	182922005	+	Silent	SNP	C	C	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:182922005C>G	uc001gpu.3	-	0	549	c.264G>C	c.(262-264)gcG>gcC	p.A88A	SHCBP1L_uc001gpv.3_5'UTR|SHCBP1L_uc010pnz.2_5'UTR|SHCBP1L_uc001gpw.3_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	Homo sapiens SHC SH2-domain binding protein 1-like (SHCBP1L), mRNA.	160										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						GCTCCTccgccgccgccgccg	0.746000													10	22					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56759888	56759888	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:56759888T>C	uc003hbe.1	+	14	2053	c.1895T>C	c.(1894-1896)cTa>cCa	p.L632P	EXOC1_uc003hbf.1_Missense_Mutation_p.L632P|EXOC1_uc003hbg.1_Missense_Mutation_p.L617P	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	Homo sapiens exocyst complex component 1 (EXOC1), transcript variant 1, mRNA.	632					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GCTTCTTTCCTAAGTACTACA	0.343000													35	72					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114483094	114483094	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:114483094G>T	uc001eem.3	+	1	250	c.89G>T	c.(88-90)gGc>gTc	p.G30V	HIPK1_uc001eel.3_Missense_Mutation_p.G30V|HIPK1_uc001een.3_Missense_Mutation_p.G30V	NM_198268	NP_938010	Q86Z02	HIPK1_HUMAN	Homo sapiens homeodomain interacting protein kinase 1 (HIPK1), transcript variant 1, mRNA.	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGCCCTCTGGCTGGGATGTT	0.507000													3	76					0.00909568	0.00956731	1	1	0
NKX2-5	1482	broad.mit.edu	37	5	172660100	172660100	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr5:172660100C>A	uc003mcm.2	-	1	676	c.447G>T	c.(445-447)caG>caT	p.Q149H	NKX2-5_uc010jjt.2_3'UTR|NKX2-5_uc011dfe.2_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	Homo sapiens NK2 homeobox 5 (NKX2-5), transcript variant 1, mRNA.	149					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)	12	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCTCATAGACCTGCGCCTGCG	0.687000													18	47					1.40151e-16	1.68656e-16	1	1	0
ZNF646	9726	broad.mit.edu	37	16	31092685	31092685	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:31092685C>T	uc002eap.3	+	1	5329	c.5040C>T	c.(5038-5040)acC>acT	p.T1680T	ZNF646_uc021tgu.1_Silent_p.T1680T	NM_014699	NP_055514	O15015	ZN646_HUMAN	Homo sapiens zinc finger protein 646 (ZNF646), mRNA.	1680					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						TCCGCTGCACCCAGTGCGGGC	0.652000													19	87					0	0	1	0	0
LOXHD1	125336	broad.mit.edu	37	18	44236995	44236995	+	Splice_Site	SNP	A	A	T	rs36024592	by1000genomes	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr18:44236995A>T	uc010xcw.1	-	1	1	c.1_splice	c.e1-1	p.M1_splice		NM_144612	NP_653213	Q8IVV2	LOXH1_HUMAN	Homo sapiens lipoxygenase homology domains 1 (LOXHD1), transcript variant 1, mRNA.	0					sensory perception of sound	stereocilium	protein binding			NS(3)|autonomic_ganglia(1)|breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(2)|pancreas(1)|prostate(4)|skin(4)|stomach(1)	36						CTGGGGCATCATTCTGTCGGC	0.642000													3	88					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195508983	195508983	+	Silent	SNP	G	G	T	rs71291868		TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:195508983G>T	uc021xjp.1	-	1	9624	c.9468C>A	c.(9466-9468)acC>acA	p.T3156T	MUC4_uc021xjm.1_5'Flank|MUC4_uc021xjn.1_5'Flank|MUC4_uc021xjo.1_5'Flank|MUC4_uc021xjg.1_5'Flank|MUC4_uc021xjh.1_5'Flank|MUC4_uc021xji.1_5'Flank|MUC4_uc021xjj.1_5'Flank|MUC4_uc021xjk.1_5'Flank|MUC4_uc021xjl.1_5'Flank|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	900					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T3156T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGTGTCGGTGACAGGAA	0.587000													3	53					0.115264	0.118605	1	1	0
ZNF853	54753	broad.mit.edu	37	7	6661545	6661545	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:6661545A>T	uc011jwz.2	+	2	1202	c.923A>T	c.(922-924)cAg>cTg	p.Q308L		NM_017560	NP_060030	P0CG23	ZN853_HUMAN	Homo sapiens zinc finger protein 853 (ZNF853), mRNA.	308	Gln-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)	2						caacaactgcagcCTCCTCCC	0.617000													18	63					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1093344	1093344	+	Silent	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:1093344G>T	uc001lsx.1	+	30	5190	c.5163G>T	c.(5161-5163)ccG>ccT	p.P1721P		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1780	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding	p.P1688P(1)|p.P1721P(1)		NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ccccaaccccgacacccatct	0.642000													4	32					0.184627	0.187265	1	1	0
MUC21	394263	broad.mit.edu	37	6	30954813	30954813	+	Silent	SNP	T	T	C	rs139085912	by1000genomes	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:30954813T>C	uc003nsh.2	+	1	1112	c.861T>C	c.(859-861)aaT>aaC	p.N287N	MUC21_uc003nsi.1_Non-coding_Transcript|MUC21_uc021yuf.1_Silent_p.N271N	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	Homo sapiens mucin 21, cell surface associated (MUC21), mRNA.	287	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CAGTCACCAATTCTGAGTCCA	0.602000													7	120					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007447	6007447	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr9:6007447T>C	uc003zjq.4	-	0	557	c.341A>G	c.(340-342)gAg>gGg	p.E114G	MIR4665_uc022bde.1_5'Flank	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	Homo sapiens KIAA2026 (KIAA2026), mRNA.	114										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTCCGCCACCTCCTCCTCCGC	0.716000													17	29					0	0	1	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67058950	67058950	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:67058950C>A	uc001okd.2	+	3	525	c.355C>A	c.(355-357)Ccc>Acc	p.P119T	ANKRD13D_uc001okc.2_Missense_Mutation_p.P32T|ANKRD13D_uc001oke.2_Missense_Mutation_p.P32T	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	Homo sapiens ankyrin repeat domain 13 family, member D (ANKRD13D), transcript variant 1, mRNA.	32										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CTCTTAGGCCCCCGATTTCTA	0.627000													8	20					0.0581538	0.0602762	1	1	0
FAM194A	131831	broad.mit.edu	37	3	150421548	150421548	+	Silent	SNP	T	T	C	rs146394127	byFrequency	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:150421548T>C	uc003eyg.3	-	0	195	c.138A>G	c.(136-138)gaA>gaG	p.E46E	FAM194A_uc003eyh.3_Intron	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	Homo sapiens family with sequence similarity 194, member A (FAM194A), mRNA.	46	Glu-rich.							p.E46E(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						cctccacctcttcctcctcct	0.607000													6	31					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49547996	49547996	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:49547996T>C	uc021wxz.1	+	1	498	c.29T>C	c.(28-30)cTg>cCg	p.L10P	DAG1_uc021wya.1_Missense_Mutation_p.L10P|DAG1_uc021wyb.1_Missense_Mutation_p.L10P|DAG1_uc021wyc.1_Missense_Mutation_p.L10P|DAG1_uc021wyd.1_Missense_Mutation_p.L10P|DAG1_uc021wye.1_Missense_Mutation_p.L10P|DAG1_uc021wyf.1_Missense_Mutation_p.L10P|DAG1_uc021wyg.1_Missense_Mutation_p.L10P|DAG1_uc021wyh.1_Missense_Mutation_p.L10P|DAG1_uc021wyi.1_Missense_Mutation_p.L10P|DAG1_uc021wyj.1_Missense_Mutation_p.L10P|DAG1_uc021wyk.1_Missense_Mutation_p.L10P|DAG1_uc003cxc.4_Missense_Mutation_p.L10P	NM_001177643	NP_001171114	Q14118	DAG1_HUMAN	Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), transcript variant 12, mRNA.	10					cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of MAPKKK cascade|negative regulation of cell migration|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CTCTCGCTGCTGCTGCCCCTC	0.577000													12	41					0	0	1	0	0
C9orf86	55684	broad.mit.edu	37	9	139734263	139734263	+	Missense_Mutation	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr9:139734263G>A	uc004cjj.1	+	12	2336	c.1879G>A	c.(1879-1881)Gac>Aac	p.D627N	C9orf86_uc004cji.1_Missense_Mutation_p.D626N|C9orf86_uc004cjk.1_Non-coding_Transcript|C9orf86_uc004cjl.1_Non-coding_Transcript|C9orf86_uc010nbs.1_Missense_Mutation_p.D511N|C9orf86_uc004cjn.1_Missense_Mutation_p.D420N	NM_001173988	NP_001167459	Q3YEC7	PARF_HUMAN	Homo sapiens chromosome 9 open reading frame 86 (C9orf86), transcript variant 3, mRNA.	626					small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding			endometrium(4)|kidney(1)|lung(4)	9	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		GAATGACTCGGACCTCTTCGG	0.657000													16	27					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85476453	85476453	+	Silent	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:85476453G>A	uc002blg.3	+	12	1363	c.1161G>A	c.(1159-1161)ccG>ccA	p.P387P	SLC28A1_uc010bnb.3_Silent_p.P387P|SLC28A1_uc010upe.2_Intron|SLC28A1_uc010upf.1_Silent_p.P387P|SLC28A1_uc010upg.1_Silent_p.P387P	NM_004213	NP_004204	O00337	S28A1_HUMAN	Homo sapiens solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), transcript variant 1, mRNA.	387					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding	p.P387L(2)|p.P387S(1)		breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGTCTACCCGGAGGTGGAGG	0.572000													13	33					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155175049	155175049	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:155175049C>T	uc001fix.3	-	2	450	c.345G>A	c.(343-345)gcG>gcA	p.A115A	THBS3_uc010pfu.2_Intron|THBS3_uc009wqi.3_Silent_p.A115A|THBS3_uc001fiy.3_5'UTR|THBS3_uc010pfv.2_Intron|THBS3_uc001fja.2_Non-coding_Transcript|THBS3_uc009wqj.1_Silent_p.A77A	NM_007112	NP_009043	P49746	TSP3_HUMAN	Homo sapiens thrombospondin 3 (THBS3), transcript variant 1, mRNA.	115	TSP N-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity	p.A115A(2)		breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CAGCCAGGCCCGCTTGCTGTA	0.627000													11	34					0	0	1	0	0
CLEC18A	348174	broad.mit.edu	37	16	69988283	69988283	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:69988283T>C	uc010vlo.2	+	3	383	c.263T>C	c.(262-264)cTc>cCc	p.L88P	CLEC18A_uc002exy.3_Missense_Mutation_p.L88P|CLEC18A_uc002exz.3_Missense_Mutation_p.L88P|CLEC18A_uc002eya.3_Missense_Mutation_p.L88P|CLEC18A_uc010vlp.2_Missense_Mutation_p.L88P	NM_001136214	NP_872425	A5D8T8	CL18A_HUMAN	Homo sapiens C-type lectin domain family 18, member A (CLEC18A), transcript variant 2, mRNA.	88	SCP.					extracellular region	sugar binding			NS(1)|endometrium(2)|lung(1)|skin(1)	5						AGGGCAGCCCTCTGTGGAACC	0.662000													156	182					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60663585	60663585	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr17:60663585C>A	uc010ddp.3	+	16	1792	c.1524C>A	c.(1522-1524)caC>caA	p.H508Q	TLK2_uc002izx.4_Missense_Mutation_p.H334Q|TLK2_uc002izz.4_Missense_Mutation_p.H486Q|TLK2_uc002jaa.4_Missense_Mutation_p.H454Q|TLK2_uc010wpd.2_Missense_Mutation_p.H454Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	Homo sapiens tousled-like kinase 2 (TLK2), transcript variant A, mRNA.	508	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						AGAATTACCACAAGTAAGTGA	0.328000													268	275					1.80343e-85	2.30709e-85	1	1	0
TTN	7273	broad.mit.edu	37	2	179431535	179431535	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:179431535T>C	uc021vsy.1	-	274	71845	c.71620A>G	c.(71620-71622)Aca>Gca	p.T23874A	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Missense_Mutation_p.T17569A|TTN_uc021vta.1_Missense_Mutation_p.T17502A|TTN_uc021vtb.1_Missense_Mutation_p.T17377A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	24801	Ig-like 120.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCAAATCTGTAATGCGGCGT	0.428000													37	18					0	0	1	0	0
LSM14A	26065	broad.mit.edu	37	19	34710315	34710315	+	Silent	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:34710315T>G	uc002nvb.4	+	6	997	c.801T>G	c.(799-801)gcT>gcG	p.A267A	LSM14A_uc002nva.4_Silent_p.A267A|LSM14A_uc010xru.2_Silent_p.A226A|LSM14A_uc002nvc.4_Silent_p.A73A	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	Homo sapiens LSM14A, SCD6 homolog A (S. cerevisiae) (LSM14A), transcript variant 1, mRNA.	267					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule		p.A267A(4)		breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					CTCCTTCAGCTCCAAGGAGAG	0.438000													3	95					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr17:62968690A>G	uc002jez.3	-	3		c.641T>C			AMZ2P1_uc002jfa.3_Non-coding_Transcript|AMZ2P1_uc002jfb.3_Non-coding_Transcript|AMZ2P1_uc010del.2_Non-coding_Transcript					Homo sapiens archaelysin family metallopeptidase 2 pseudogene 1 (AMZ2P1), non-coding RNA.																		AAAATTCCACAAGTCTCTTGG	0.373000													4	185					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135372389	135372389	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr10:135372389A>T	uc001lno.2	-	3	368	c.263T>A	c.(262-264)cTg>cAg	p.L88Q	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_5'UTR|SYCE1_uc009ybn.2_Missense_Mutation_p.L88Q|SYCE1_uc001lnn.2_Missense_Mutation_p.L52Q	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	Homo sapiens synaptonemal complex central element protein 1 (SYCE1), transcript variant 4, mRNA.	88					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		ACGCGAGTCCAGTTCCTTCTG	0.527000													17	41					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10522421	10522421	+	Missense_Mutation	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:10522421T>G	uc003gmo.4	-	14	903	c.766A>C	c.(766-768)Aac>Cac	p.N256H		NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	Homo sapiens cytokine-dependent hematopoietic cell linker (CLNK), mRNA.	256					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						TTACCTCTGTTTTGCACACTG	0.373000													31	62					0	0	1	0	0
WDR67	93594	broad.mit.edu	37	8	124154514	124154514	+	Missense_Mutation	SNP	A	A	T	rs144810574	byFrequency	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr8:124154514A>T	uc003ypp.2	+	18	2743	c.2653A>T	c.(2653-2655)Aat>Tat	p.N885Y	WDR67_uc011lig.2_Intron|WDR67_uc011lih.2_Missense_Mutation_p.N775Y|WDR67_uc003ypq.2_Intron|WDR67_uc003yps.2_Missense_Mutation_p.N519Y|WDR67_uc003ypu.2_Intron	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	Homo sapiens WD repeat domain 67 (WDR67), transcript variant 1, mRNA.	885						centrosome	Rab GTPase activator activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GATTAAAGAAAATTTGGCAAA	0.338000													89	209					0	0	1	0	0
GPR137C	283554	broad.mit.edu	37	14	53099007	53099007	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr14:53099007T>A	uc001wzt.4	+	4	895	c.895T>A	c.(895-897)Tgg>Agg	p.W299R	GPR137C_uc001wzu.4_Missense_Mutation_p.W283R	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	Homo sapiens G protein-coupled receptor 137C (GPR137C), mRNA.	283						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8	Breast(41;0.0716)					TAATTATGGCTGGGATAATCT	0.378000													20	89					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31154780	31154780	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:31154780G>T	uc002ebd.3	-	7	1042	c.983C>A	c.(982-984)gCc>gAc	p.A328D	PRSS36_uc010vff.2_Missense_Mutation_p.A103D|PRSS36_uc010vfg.2_Missense_Mutation_p.A328D|PRSS36_uc010vfh.2_Missense_Mutation_p.A328D	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	Homo sapiens protease, serine, 36 (PRSS36), mRNA.	328	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						TGGCCGCGGGGCCTTCCCGCA	0.667000													7	63					0.0381472	0.0398302	1	1	0
SECISBP2L	9728	broad.mit.edu	37	15	49304926	49304926	+	Silent	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:49304926A>T	uc001zxe.2	-	11	1914	c.1650T>A	c.(1648-1650)tcT>tcA	p.S550S	SECISBP2L_uc001zxd.2_Silent_p.S505S|SECISBP2L_uc010bep.2_Silent_p.S312S	NM_001193489	NP_001180418	Q93073	SBP2L_HUMAN	Homo sapiens SECIS binding protein 2-like (SECISBP2L), transcript variant 1, mRNA.	550										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						CAATGTCCACAGAATTAAAGG	0.358000													30	97					0	0	1	0	0
IFITM3	10410	broad.mit.edu	37	11	320649	320649	+	Silent	SNP	G	G	A	rs11553885	by1000genomes	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:320649G>A	uc001lpa.2	-	0	266	c.165C>T	c.(163-165)ccC>ccT	p.P55P	BC040735_uc001loz.3_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	Homo sapiens interferon induced transmembrane protein 3 (IFITM3), mRNA.	55					response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P55P(10)		central_nervous_system(7)|endometrium(7)|kidney(2)|large_intestine(1)|lung(1)	18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGACATGGTCGGGCACGGAGG	0.637000													3	61					0	0	1	0	0
PIM3	415116	broad.mit.edu	37	22	50355280	50355280	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr22:50355280T>C	uc003bjb.3	+	3	890	c.437T>C	c.(436-438)cTg>cCg	p.L146P	PIM3_uc011arj.2_5'Flank	NM_001001852	NP_001001852	Q86V86	PIM3_HUMAN	Homo sapiens pim-3 oncogene (PIM3), mRNA.	146	Protein kinase.				cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity						all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		GACGAGCCGCTGGCGCGCCGC	0.692000													11	19					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35758158	35758158	+	Missense_Mutation	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr13:35758158T>G	uc021rid.1	+	29	5411	c.4877T>G	c.(4876-4878)tTc>tGc	p.F1626C	NBEA_uc021ric.1_Missense_Mutation_p.F1623C|NBEA_uc010abi.3_Intron	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	Homo sapiens neurobeachin (NBEA), transcript variant 1, mRNA.	1626						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding	p.G1625V(1)		NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AACCATGGATTCCTTGCCAAG	0.413000													26	57					0	0	1	0	0
TMED4	222068	broad.mit.edu	37	7	44621390	44621390	+	Missense_Mutation	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:44621390T>G	uc003tli.3	-	1	215	c.193A>C	c.(193-195)Aag>Cag	p.K65Q	TMED4_uc003tlj.3_Missense_Mutation_p.K6Q|TMED4_uc003tlk.3_Missense_Mutation_p.K65Q|DQ574505_uc003tll.3_5'Flank	NM_182547	NP_872353	Q7Z7H5	TMED4_HUMAN	Homo sapiens transmembrane emp24 protein transport domain containing 4 (TMED4), mRNA.	65	GOLD.				positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6						AAGACCTCCTTCTGCTTATCC	0.657000													40	53					0	0	1	0	0
SRP14	6727	broad.mit.edu	37	15	40331316	40331316	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:40331316A>G	uc001zkq.2	-	0	74	c.2T>C	c.(1-3)aTg>aCg	p.M1T	SRP14_uc001zkr.2_Missense_Mutation_p.M1T|LOC100131089_uc021sjc.1_5'Flank|LOC100131089_uc021sjd.1_5'Flank|LOC100131089_uc021sje.1_5'Flank|LOC100131089_uc001zks.2_5'Flank	NM_003134	NP_003125	P37108	SRP14_HUMAN	Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein) (SRP14), mRNA.	1					SRP-dependent cotranslational protein targeting to membrane|negative regulation of translational elongation|response to drug	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		CAACAACACCATCGCGGCGAC	0.652000													5	41					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128489441	128489441	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:128489441G>T	uc003vnz.4	+	29	5217	c.5008G>T	c.(5008-5010)Gcc>Tcc	p.A1670S	FLNC_uc003voa.4_Missense_Mutation_p.A1670S	NM_001458	NP_001449	Q14315	FLNC_HUMAN	Homo sapiens filamin C, gamma (FLNC), transcript variant 1, mRNA.	1670					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CACGGTGGATGCCAAGGCAGC	0.627000													3	83					0.004672	0.00498815	1	1	0
PTPRR	5801	broad.mit.edu	37	12	71139777	71139777	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:71139777T>A	uc001swi.2	-	5	1242	c.828A>T	c.(826-828)ttA>ttT	p.L276F	PTPRR_uc001swh.2_Missense_Mutation_p.L31F|PTPRR_uc009zrs.3_Missense_Mutation_p.L70F|PTPRR_uc010stq.2_Missense_Mutation_p.L164F|PTPRR_uc010str.1_Missense_Mutation_p.L125F	NM_002849	NP_570897	Q15256	PTPRR_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, R (PTPRR), transcript variant 1, mRNA.	276					in utero embryonic development	Golgi apparatus|cell surface|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GTGCTGGCTGTAATGTGATGG	0.473000													29	79					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159166790	159166790	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:159166790G>T	uc001ftl.2	+	6	1071	c.892G>T	c.(892-894)Ggc>Tgc	p.G298C	CADM3_uc009wsy.1_Missense_Mutation_p.G252C|CADM3_uc001ftk.2_Missense_Mutation_p.G332C|LOC100131825_uc001ftm.2_Non-coding_Transcript	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	Homo sapiens cell adhesion molecule 3 (CADM3), transcript variant 2, mRNA.	298	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.Q298H(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					TGGCACCTACGGCTGCACAGC	0.542000													3	86					0.00909568	0.00956731	1	1	0
FBN3	84467	broad.mit.edu	37	19	8183905	8183905	+	Splice_Site	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:8183905G>A	uc002mjf.3	-	25	3229	c.3212_splice	c.e25-1	p.D1071_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	Homo sapiens fibrillin 3 (FBN3), mRNA.	1071	EGF-like 14; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACTCGTCCACGTCTGAAGGTT	0.617000													10	14					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72984405	72984405	+	Missense_Mutation	SNP	A	A	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:72984405A>C	uc002fck.3	-	2	3852	c.3179T>G	c.(3178-3180)gTc>gGc	p.V1060G	ZFHX3_uc002fcl.3_Missense_Mutation_p.V146G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	1060					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CCTGGAGTTGACCGTGTGCAG	0.602000													33	31					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2939488	2939488	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr18:2939488T>C	uc002klo.3	-	5	1051	c.812A>G	c.(811-813)gAg>gGg	p.E271G		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	Homo sapiens lipin 2 (LPIN2), mRNA.	271					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTTGGTGGACTCTGGGAATCC	0.493000													13	21					0	0	1	0	0
DNAJC17	55192	broad.mit.edu	37	15	41099608	41099608	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:41099608A>G	uc001zms.2	-	0	69	c.37T>C	c.(37-39)Tac>Cac	p.Y13H	DNAJC17_uc010bbz.2_Non-coding_Transcript|DNAJC17_uc010bca.2_Non-coding_Transcript|DNAJC17_uc010bcb.2_Non-coding_Transcript|ZFYVE19_uc001zmt.1_5'UTR|ZFYVE19_uc001zmu.1_5'UTR|ZFYVE19_uc001zmv.1_5'UTR	NM_018163	NP_060633	Q9NVM6	DJC17_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 17 (DNAJC17), mRNA.	13	J.				protein folding		RNA binding|heat shock protein binding|nucleotide binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|skin(1)	6		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		AGCAGCGCGTACAGGTCCATC	0.577000													34	92					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65114469	65114469	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:65114469A>T	uc002ant.2	-	3	879	c.813T>A	c.(811-813)ttT>ttA	p.F271L	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Missense_Mutation_p.F271L|PIF1_uc002anu.3_3'UTR	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	Homo sapiens PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) (PIF1), mRNA.	271	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						ACTTACCTGCAAAGGCATGGA	0.612000													4	17					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40010765	40010765	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr17:40010765T>C	uc002hyf.1	-	1	1360	c.1354A>G	c.(1354-1356)Aaa>Gaa	p.K452E		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	Homo sapiens kelch-like 11 (Drosophila) (KLHL11), mRNA.	452						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				AGCTTCCCTTTGACTTCTGTT	0.373000													82	97					0	0	1	0	0
CERS5	91012	broad.mit.edu	37	12	50529605	50529605	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:50529605T>C	uc001rwd.4	-	7	799	c.782A>G	c.(781-783)aAt>aGt	p.N261S	CERS5_uc001rwc.3_Missense_Mutation_p.N180S|CERS5_uc001rwe.4_Missense_Mutation_p.N202S|CERS5_uc001rwf.4_Non-coding_Transcript|CERS5_uc010smq.1_Missense_Mutation_p.N117S	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	Homo sapiens ceramide synthase 5 (CERS5), mRNA.	261	TLC.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CTTGGCATAATTGGCCAGTTT	0.428000													18	54					0	0	1	0	0
ZNF474	133923	broad.mit.edu	37	5	121487756	121487756	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr5:121487756C>A	uc003ksv.3	+	1	447	c.71C>A	c.(70-72)aCt>aAt	p.T24N	ZNF474_uc021ycy.1_Missense_Mutation_p.T24N	NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	Homo sapiens zinc finger protein 474 (ZNF474), mRNA.	24						intracellular	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|stomach(1)	21		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		AAAGAACCCACTTTCCTTATC	0.378000													23	62					2.98393e-07	3.38975e-07	1	1	0
KIF18B	146909	broad.mit.edu	37	17	43009571	43009571	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr17:43009571C>T	uc010wji.2	-	9	1379	c.1278G>A	c.(1276-1278)caG>caA	p.Q426Q	KIF18B_uc002iht.3_Silent_p.Q426Q|KIF18B_uc010wjh.2_Silent_p.Q414Q	NM_001080443	NP_001073912			Homo sapiens kinesin family member 18B (KIF18B), mRNA.											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				GGGTGCAGGGCTGGCTGGGAG	0.657000													6	38					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196888577	196888577	+	Silent	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:196888577A>T	uc010ial.3	-	5	775	c.516T>A	c.(514-516)acT>acA	p.T172T	DLG1_uc011bub.2_Intron|DLG1_uc011buc.2_Intron|DLG1_uc011bud.2_Intron|DLG1_uc003fxo.4_Silent_p.T172T|DLG1_uc003fxn.4_Silent_p.T172T|DLG1_uc011bue.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Non-coding_Transcript|DLG1_uc010iam.1_Intron|DLG1_uc010ian.2_Intron	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	Homo sapiens discs, large homolog 1 (Drosophila) (DLG1), transcript variant 1, mRNA.	172	Interaction with SH3 domains.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	MPP7-DLG1-LIN7 complex|basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	L27 domain binding|cytoskeletal protein binding|guanylate kinase activity|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein C-terminus binding|protein binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TCACAGGGACAGTGGGAGGAG	0.388000													76	233					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130866576	130866576	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr8:130866576G>T	uc003yss.3	-	9	1001	c.452C>A	c.(451-453)gCc>gAc	p.A151D	FAM49B_uc003yst.3_Missense_Mutation_p.A151D|FAM49B_uc003ysu.3_Missense_Mutation_p.A151D|FAM49B_uc003ysw.3_Missense_Mutation_p.A151D|FAM49B_uc003ysx.3_Missense_Mutation_p.A151D|FAM49B_uc003ysy.1_Missense_Mutation_p.A151D	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	Homo sapiens family with sequence similarity 49, member B (FAM49B), mRNA.	151										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			ATTCTGTATGGCAGGATTTGT	0.308000													3	79					1	1	1	1	0
RAI2	10742	broad.mit.edu	37	X	17819166	17819166	+	Missense_Mutation	SNP	T	T	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chrX:17819166T>G	uc022btm.1	-	0	965	c.965A>C	c.(964-966)aAg>aCg	p.K322T	RAI2_uc004cyf.3_Missense_Mutation_p.K322T|RAI2_uc004cyg.3_Missense_Mutation_p.K322T|RAI2_uc011miy.2_Missense_Mutation_p.K272T|RAI2_uc022btl.1_Missense_Mutation_p.K322T|RAI2_uc004cyh.4_Missense_Mutation_p.K322T|RAI2_uc010nfa.3_Missense_Mutation_p.K322T	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	Homo sapiens retinoic acid induced 2 (RAI2), transcript variant 2, mRNA.	322					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GGGCACTGACTTCATGGAGAG	0.567000													3	52					0	0	1	0	0
FAM20C	56975	broad.mit.edu	37	7	193561	193561	+	Nonsense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:193561T>A	uc003sip.3	+	0	593	c.362T>A	c.(361-363)tTg>tAg	p.L121*		NM_020223	NP_064608	Q8IXL6	DMP4_HUMAN	Homo sapiens family with sequence similarity 20, member C (FAM20C), mRNA.	121						extracellular region				endometrium(1)|lung(2)|urinary_tract(1)	4		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.57e-17)|Epithelial(4;1.26e-16)|all cancers(6;4.79e-14)		GAGCGCGCCTTGCGGGGGCGG	0.766000													12	10					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97215160	97215160	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:97215160C>A	uc002swe.3	+	2	323	c.223C>A	c.(223-225)Ccc>Acc	p.P75T	ARID5A_uc010yuq.2_5'UTR|ARID5A_uc002swf.3_Intron|ARID5A_uc002swg.3_Intron	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), mRNA.	75	ARID.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						GCGACACACGCCCATCGAGAG	0.697000													66	49					2.03366e-24	2.53316e-24	1	1	0
ZNF597	146434	broad.mit.edu	37	16	3487293	3487293	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:3487293A>T	uc002cvd.3	-	3	590	c.406T>A	c.(406-408)Tta>Ata	p.L136I		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	Homo sapiens zinc finger protein 597 (ZNF597), mRNA.	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						TTGGTTCCTAAATATTCAGAG	0.403000													102	75					0	0	1	0	0
USP46	64854	broad.mit.edu	37	4	53492228	53492228	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:53492228T>C	uc003gzn.3	-	3	703	c.518A>G	c.(517-519)cAg>cGg	p.Q173R	USP46_uc003gzm.4_Missense_Mutation_p.Q166R|USP46_uc011bzr.2_Missense_Mutation_p.Q150R|USP46_uc011bzs.2_Missense_Mutation_p.Q57R	NM_022832	NP_073743	P62068	UBP46_HUMAN	Homo sapiens ubiquitin specific peptidase 46 (USP46), transcript variant 1, mRNA.	173					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			AAGCGTTCCCTGAAAAATCTC	0.383000													52	117					0	0	1	0	0
USP13	8975	broad.mit.edu	37	3	179462840	179462840	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:179462840T>A	uc003fkh.3	+	12	1625	c.1544T>A	c.(1543-1545)aTc>aAc	p.I515N		NM_003940	NP_003931	Q92995	UBP13_HUMAN	Homo sapiens ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), mRNA.	515					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.I515I(1)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GATGAACTGATCGCTTATGAA	0.478000													53	80					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960794	29960794	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr20:29960794G>T	uc002wvr.3	+	1	226	c.193G>T	c.(193-195)Gtt>Ttt	p.V65F		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	Homo sapiens defensin, beta 118 (DEFB118), mRNA.	65					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region		p.R64L(1)		breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCACAGGCGAGTTCCTGCGAC	0.443000													24	68					2.24059e-21	2.76665e-21	1	1	0
SCRIB	23513	broad.mit.edu	37	8	144892982	144892982	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr8:144892982A>T	uc003yzp.1	-	11	1285	c.1278T>A	c.(1276-1278)gaT>gaA	p.D426E	SCRIB_uc003yzo.1_Missense_Mutation_p.D426E	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	Homo sapiens scribbled homolog (Drosophila) (SCRIB), transcript variant 2, mRNA.	426	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	Scrib-APC-beta-catenin complex|cell-cell adherens junction	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCTGCCCAGCATCCTCTGCAG	0.662000													6	12					0	0	1	0	0
ZNF576	79177	broad.mit.edu	37	19	44103092	44103092	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:44103092G>T	uc002owz.2	+	2	368	c.195G>T	c.(193-195)aaG>aaT	p.K65N	IRGQ_uc010eiv.2_5'Flank|ZNF576_uc002owy.2_Missense_Mutation_p.K65N|SRRM5_uc002oxb.2_Intron	NM_001145347	NP_077303	Q9H609	ZN576_HUMAN	Homo sapiens zinc finger protein 576 (ZNF576), transcript variant 2, mRNA.	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|prostate(1)	2		Prostate(69;0.0199)				TGGCCCAGAAGCTGCAGGGGG	0.647000													3	55					0.150653	0.153905	1	1	0
TPX2	22974	broad.mit.edu	37	20	30388879	30388879	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr20:30388879G>T	uc002wwp.1	+	17	2938	c.2240G>T	c.(2239-2241)tGc>tTc	p.C747F	TPX2_uc010gdv.1_Missense_Mutation_p.C783F	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2), mRNA.	747					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			CGATTCCACTGCTAAACTCAG	0.512000													21	40					1.55795e-14	1.84357e-14	1	1	0
FARP1	10160	broad.mit.edu	37	13	98865472	98865472	+	Splice_Site	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr13:98865472A>G	uc001vnh.3	+	2	217	c.-22_splice	c.e2-2		FARP1_uc001vni.3_Splice_Site|FARP1_uc001vnj.3_Splice_Site	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	Homo sapiens FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) (FARP1), transcript variant 1, mRNA.						regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	Rho guanyl-nucleotide exchange factor activity|cytoskeletal protein binding			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGCTTCCTGCAGATATTCTCT	0.552000													19	42					0	0	1	0	0
PPARG	5468	broad.mit.edu	37	3	12447397	12447397	+	Silent	SNP	G	G	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:12447397G>C	uc003bwx.3	+	4	727	c.636G>C	c.(634-636)cgG>cgC	p.R212R	PPARG_uc003bwr.3_Silent_p.R184R|PPARG_uc003bws.3_Silent_p.R184R|PPARG_uc003bwu.3_Silent_p.R184R|PPARG_uc003bwv.3_Silent_p.R184R|PPARG_uc010hea.1_Non-coding_Transcript|PPARG_uc003bwt.1_Silent_p.R184R|PPARG_uc003bww.1_Silent_p.R212R	NM_015869	NP_619726	P37231	PPARG_HUMAN	Homo sapiens peroxisome proliferator-activated receptor gamma (PPARG), transcript variant 2, mRNA.	212	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	GGTTTGGGCGGATGCCACAGG	0.542000			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						4	68					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53380907	53380907	+	Splice_Site	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:53380907C>T	uc003pbw.2	-	4	1044	c.560_splice	c.e4+1	p.S187_splice	GCLC_uc021zau.1_Intron|GCLC_uc003pbx.3_Splice_Site_p.S187_splice	NM_001498	NP_001489	P48506	GSH1_HUMAN	Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1, mRNA.	187					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CCATACTCACCTGAAGCGAGG	0.468000													12	44					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74325643	74325643	+	Silent	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:74325643G>A	uc002awv.3	+	5	1685	c.1545G>A	c.(1543-1545)aaG>aaA	p.K515K	PML_uc002awj.1_Silent_p.K467K|PML_uc002awm.3_Silent_p.K515K|PML_uc002awl.3_Intron|PML_uc002awk.3_Silent_p.K515K|PML_uc002awn.3_Silent_p.K515K|PML_uc002awo.3_Silent_p.K467K|PML_uc002awp.3_Intron|PML_uc002awq.3_Silent_p.K515K|PML_uc002awr.3_Silent_p.K515K|PML_uc002aws.3_Silent_p.K467K|PML_uc002awt.3_Intron|PML_uc002awu.3_Silent_p.K467K|PML_uc010ule.2_Silent_p.K76K|PML_uc002awx.3_Silent_p.K225K|PML_uc002awy.3_5'UTR	NM_033238	NP_150241	P29590	PML_HUMAN	Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA.	515					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|PML body organization|cell cycle arrest|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	PML body|cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus	DNA binding|SUMO binding|cobalt ion binding|protein binding|protein heterodimerization activity|protein homodimerization activity|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						GCACCTCCAAGGCAGTCTCAC	0.652000			T	"""RARA, PAX5"""	"""APL, ALL"""								19	60					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62637691	62637691	+	Silent	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr10:62637691G>A	uc001jli.3	-	8	2139	c.1701C>T	c.(1699-1701)tgC>tgT	p.C567C	RHOBTB1_uc009xpe.2_Silent_p.C505C|RHOBTB1_uc001jlh.3_Silent_p.C567C|RHOBTB1_uc001jlj.3_Silent_p.C567C|RHOBTB1_uc001jlk.3_Silent_p.C567C|RHOBTB1_uc009xpd.3_Silent_p.C32C	NM_001242359	NP_001229288	O94844	RHBT1_HUMAN	Homo sapiens Rho-related BTB domain containing 1 (RHOBTB1), transcript variant 4, mRNA.	567					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGTGTGGCAGGCAAAATCTGT	0.403000													4	120					0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379052	204379052	+	Silent	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:204379052A>G	uc001hav.4	-	0	1893	c.1488T>C	c.(1486-1488)atT>atC	p.I496I		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 15B (PPP1R15B), mRNA.	496					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CAGCAGTCTGAATTGTTGCTG	0.458000													21	44					0	0	1	0	0
MFAP1	4236	broad.mit.edu	37	15	44105507	44105507	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:44105507C>T	uc001zth.1	-	4	850	c.666G>A	c.(664-666)caG>caA	p.Q222Q		NM_005926	NP_005917	P55081	MFAP1_HUMAN	Homo sapiens microfibrillar-associated protein 1 (MFAP1), mRNA.	222						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		CCAGCTCCTTCTGTTTCAATG	0.488000													19	41					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24579518	24579518	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr22:24579518T>A	uc002zzn.1	+	2	387	c.343T>A	c.(343-345)Tgt>Agt	p.C115S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	Homo sapiens sushi domain containing 2 (SUSD2), mRNA.	115					immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						GCAAGTGCACTGTGTGTCACC	0.632000													18	22					0	0	1	0	0
FBXO46	23403	broad.mit.edu	37	19	46215777	46215777	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:46215777A>G	uc002pcz.3	-	1	1100	c.977T>C	c.(976-978)cTg>cCg	p.L326P	FBXO46_uc002pcy.3_Missense_Mutation_p.L326P|FBXO46_uc021uvz.1_Missense_Mutation_p.L326P	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	Homo sapiens F-box protein 46 (FBXO46), mRNA.	326							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		CCTGGCCAGCAGGAACTCCAC	0.697000													23	57					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139707081	139707081	+	Silent	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr8:139707081C>A	uc003yvd.3	-	32	3081	c.2634G>T	c.(2632-2634)ctG>ctT	p.L878L	COL22A1_uc011ljo.2_Silent_p.L178L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	Homo sapiens collagen, type XXII, alpha 1 (COL22A1), mRNA.	878	Collagen-like 7.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTTCCCCAGGCAGGCCTGGAT	0.607000										HNSCC(7;0.00092)			12	30					0.000308642	0.000339745	1	1	0
BCRP3	644165	broad.mit.edu	37	22	25029285	25029285	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr22:25029285T>C	uc011ajv.2	+	0	404	c.47T>C	c.(46-48)cTg>cCg	p.L16P						Homo sapiens breakpoint cluster region pseudogene 3 (BCRP3), non-coding RNA.																		CTGCTGGGGCTGGGGCTTGTG	0.662000													13	32					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678517	87678517	+	Missense_Mutation	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:87678517G>A	uc002fkd.3	+	1	1290	c.1036G>A	c.(1036-1038)Ggc>Agc	p.G346S	JPH3_uc010vou.1_Non-coding_Transcript	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	Homo sapiens junctophilin 3 (JPH3), mRNA.	346					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCTCGTCGGCGGCAAGCGCAA	0.677000													24	36					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135372390	135372390	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr10:135372390G>T	uc001lno.2	-	3	367	c.262C>A	c.(262-264)Ctg>Atg	p.L88M	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_5'UTR|SYCE1_uc009ybn.2_Missense_Mutation_p.L88M|SYCE1_uc001lnn.2_Missense_Mutation_p.L52M	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	Homo sapiens synaptonemal complex central element protein 1 (SYCE1), transcript variant 4, mRNA.	88					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CGCGAGTCCAGTTCCTTCTGC	0.527000													17	40					1.96292e-10	2.26614e-10	1	1	0
SNX12	29934	broad.mit.edu	37	X	70280928	70280928	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chrX:70280928G>T	uc004dyr.1	-	3	502	c.427C>A	c.(427-429)Cac>Aac	p.H143N	SNX12_uc004dyp.1_Non-coding_Transcript|BC080535_uc004dyq.3_5'Flank	NM_013346	NP_037478	Q9UMY4	SNX12_HUMAN	Homo sapiens sorting nexin 12 (SNX12), transcript variant 2, mRNA.	143	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding|protein binding	p.H143Y(2)		endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	Renal(35;0.156)					AGGAACATGTGTAGGCAGCGT	0.517000													27	13					5.77227e-19	7.06606e-19	1	1	0
GCLC	2729	broad.mit.edu	37	6	53380911	53380911	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:53380911A>G	uc003pbw.2	-	3	1040	c.556T>C	c.(556-558)Ttc>Ctc	p.F186L	GCLC_uc021zau.1_Intron|GCLC_uc003pbx.3_Missense_Mutation_p.F186L	NM_001498	NP_001489	P48506	GSH1_HUMAN	Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1, mRNA.	186					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ACTCACCTGAAGCGAGGGTGC	0.473000													12	45					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11582721	11582721	+	Missense_Mutation	SNP	A	A	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:11582721A>C	uc021zzo.1	-	4	1729	c.1477T>G	c.(1477-1479)Tta>Gta	p.L493V	THSD7A_uc021zzn.1_Missense_Mutation_p.L493V	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	Homo sapiens thrombospondin, type I, domain containing 7A (THSD7A), mRNA.	493	TSP type-1 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCAGTGCATAATTTTAAGTCC	0.383000										HNSCC(18;0.044)			63	77					0	0	1	0	0
CYP21A1P	1590	broad.mit.edu	37	6	31975054	31975054	+	Silent	SNP	G	G	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:31975054G>C	uc021yve.1	+	4	1231	c.669G>C	c.(667-669)ctG>ctC	p.L223L				Q5ST44	Q5ST44_HUMAN	Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene (CYP21A1P), non-coding RNA.	219							electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										AGGAGAGCCTGGTGGCAGGCC	0.617000													5	97					0	0	1	0	0
PIEZO1	9780	broad.mit.edu	37	16	88800395	88800395	+	Missense_Mutation	SNP	C	C	G	rs144777557		TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr16:88800395C>G	uc010vpb.2	-	16	2248	c.2248G>C	c.(2248-2250)Gag>Cag	p.E750Q	PIEZO1_uc010cib.3_Missense_Mutation_p.E287Q|AK294743_uc010vpc.1_Intron	NM_001142864	NP_001136336	Q92508	PIEZ1_HUMAN	Homo sapiens piezo-type mechanosensitive ion channel component 1 (PIEZO1), mRNA.	750				Missing (in Ref. 3; BAA13240 and 4; AAI50272).		ER-Golgi intermediate compartment membrane|endoplasmic reticulum membrane|integral to membrane|plasma membrane	ion channel activity	p.Q749delQ(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|prostate(2)|skin(1)	10						tcctcctcctcctgctgctgc	0.667000													3	56					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12303827	12303827	+	Silent	SNP	G	G	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:12303827G>C	uc001rah.4	-	12	3079	c.2937C>G	c.(2935-2937)ctC>ctG	p.L979L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Silent_p.L979L	NM_002336	NP_002327	O75581	LRP6_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6), mRNA.	979	Beta-propeller 4.				Wnt receptor signaling pathway involved in dorsal/ventral axis specification|cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	Wnt-protein binding|coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				CAATCCAATAGAGTTGCTTGT	0.468000													29	78					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226570817	226570817	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:226570817T>A	uc001hqd.4	-	7	1250	c.1079A>T	c.(1078-1080)gAa>gTa	p.E360V		NM_001618	NP_001609	P09874	PARP1_HUMAN	Homo sapiens poly (ADP-ribose) polymerase 1 (PARP1), mRNA.	360					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|NAD+ ADP-ribosyltransferase activity|identical protein binding|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GGCGCTGGTTTCTGGGGGGAA	0.507000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					29	48					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71236101	71236101	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:71236101A>G	uc003pfj.3	+	12	3447	c.3314A>G	c.(3313-3315)tAt>tGt	p.Y1105C	FAM135A_uc003pfi.3_Missense_Mutation_p.Y909C|FAM135A_uc003pfh.3_Missense_Mutation_p.Y892C|FAM135A_uc003pfl.3_Missense_Mutation_p.Y772C|FAM135A_uc003pfn.3_Missense_Mutation_p.Y311C|FAM135A_uc003pfo.1_Missense_Mutation_p.Y476C|FAM135A_uc010kan.2_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	Homo sapiens family with sequence similarity 135, member A (FAM135A), transcript variant 3, mRNA.	1105										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GAAACAGATTATTCAGCTTTG	0.348000													42	93					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73581573	73581573	+	Missense_Mutation	SNP	C	C	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr15:73581573C>A	uc002avm.4	+	24	3928	c.3736C>A	c.(3736-3738)Ccc>Acc	p.P1246T	NEO1_uc010ukx.2_Missense_Mutation_p.P1235T|NEO1_uc010uky.2_Missense_Mutation_p.P1246T|NEO1_uc002avn.4_Missense_Mutation_p.P1239T|NEO1_uc010ukz.2_Missense_Mutation_p.P659T	NM_002499	NP_002490	Q92859	NEO1_HUMAN	Homo sapiens neogenin 1 (NEO1), transcript variant 1, mRNA.	1246					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						CTCCCAGCCACCCCAGCGTAA	0.458000													26	35					6.38683e-12	7.49529e-12	1	1	0
PITPNM1	9600	broad.mit.edu	37	11	67267651	67267651	+	Silent	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:67267651G>A	uc001olx.3	-	4	1071	c.882C>T	c.(880-882)ccC>ccT	p.P294P	PITPNM1_uc001olw.3_5'Flank|PITPNM1_uc001oly.3_Silent_p.P294P|PITPNM1_uc001olz.3_Silent_p.P294P	NM_004910	NP_004901	O00562	PITM1_HUMAN	Homo sapiens phosphatidylinositol transfer protein, membrane-associated 1 (PITPNM1), transcript variant 1, mRNA.	294					brain development|lipid metabolic process|phototransduction|protein transport	Golgi cisterna membrane|cleavage furrow|endoplasmic reticulum membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						CTGGGCCTGGGGGGGCCTCAG	0.692000													10	12					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52361913	52361913	+	Missense_Mutation	SNP	G	G	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:52361913G>A	uc011bef.2	+	5	1015	c.754G>A	c.(754-756)Gac>Aac	p.D252N	DNAH1_uc003ddt.1_Missense_Mutation_p.D252N	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA.	252	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGACAATGAGGACTTTGACTG	0.572000													5	132					0	0	1	0	0
CLIP3	25999	broad.mit.edu	37	19	36523200	36523200	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr19:36523200C>T	uc010eeq.2	-	0	374	c.60G>A	c.(58-60)gaG>gaA	p.E20E	BC071809_uc002ocy.3_Intron|CLIP3_uc002ocz.2_Silent_p.E20E	NM_001199570	NP_001186499	Q96DZ5	CLIP3_HUMAN	Homo sapiens CAP-GLY domain containing linker protein 3 (CLIP3), transcript variant 1, mRNA.	20	Poly-Glu.				chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	Golgi stack|early endosome membrane|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			cctcctcctcctcttcttcct	0.701000													3	76					0	0	1	0	0
LOC100233156	100233156	broad.mit.edu	37	GL000218.1	40771	40771	+	Silent	SNP	A	A	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chrGL000218.1:40771A>C	uc011mfn.2	-	2	248	c.159T>G	c.(157-159)ctT>ctG	p.L53L	LOC100233156_uc003jah.2_Silent_p.L53L					Homo sapiens tektin 4 pseudogene (LOC100233156), transcript variant 1, non-coding RNA.																		TGCAGTCCACAAGCACCCACA	0.667000													5	93					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197020002	197020002	+	Silent	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:197020002T>C	uc001gtt.1	-	9	1607	c.1563A>G	c.(1561-1563)aaA>aaG	p.K521K		NM_001994	NP_001985	P05160	F13B_HUMAN	Homo sapiens coagulation factor XIII, B polypeptide (F13B), mRNA.	521					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TGCACATTCCTTTAGATTCTG	0.348000													26	33					0	0	1	0	0
SLC9A6	10479	broad.mit.edu	37	X	135098843	135098843	+	Missense_Mutation	SNP	T	T	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chrX:135098843T>A	uc004ezk.3	+	9	1352	c.1276T>A	c.(1276-1278)Ttc>Atc	p.F426I	SLC9A6_uc011mvx.2_Missense_Mutation_p.F374I|SLC9A6_uc004ezj.3_Missense_Mutation_p.F394I	NM_001042537	NP_001036002	Q92581	SL9A6_HUMAN	Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6), transcript variant 1, mRNA.	394					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					GAATTTCATCTTCTCCTACAT	0.348000													31	24					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235345203	235345203	+	Missense_Mutation	SNP	A	A	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:235345203A>T	uc021pks.1	-	19	3408	c.3031T>A	c.(3031-3033)Ttt>Att	p.F1011I	ARID4B_uc001hwq.3_Missense_Mutation_p.F1011I|ARID4B_uc001hwr.3_Missense_Mutation_p.F925I|ARID4B_uc001hws.4_Missense_Mutation_p.F925I|RBM34_uc001hwp.3_Non-coding_Transcript|ARID4B_uc001hwt.4_Missense_Mutation_p.F692I	NM_001206794	NP_001193723	Q4LE39	ARI4B_HUMAN	Homo sapiens AT rich interactive domain 4B (RBP1-like) (ARID4B), transcript variant 3, mRNA.	1011					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			CTACTTGGAAATTCTGCTTTT	0.438000													22	45					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40010766	40010766	+	Silent	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr17:40010766G>T	uc002hyf.1	-	1	1359	c.1353C>A	c.(1351-1353)gtC>gtA	p.V451V		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	Homo sapiens kelch-like 11 (Drosophila) (KLHL11), mRNA.	451						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				GCTTCCCTTTGACTTCTGTTA	0.378000													82	96					9.59502e-57	1.21651e-56	1	1	0
XRCC2	7516	broad.mit.edu	37	7	152345944	152345944	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:152345944G>T	uc003wld.3	-	2	712	c.626C>A	c.(625-627)cCt>cAt	p.P209H		NM_005431	NP_005422	O43543	XRCC2_HUMAN	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2), mRNA.	209					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			NS(1)|breast(1)|large_intestine(5)|liver(1)|lung(1)|prostate(2)	11		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		GGCATGAGAAGGTTCTTCTGA	0.453000								Homologous recombination					16	60					1.37285e-15	1.6382e-15	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38863980	38863980	+	Missense_Mutation	SNP	A	A	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:38863980A>C	uc021yzh.1	+	59	9028	c.8919A>C	c.(8917-8919)gaA>gaC	p.E2973D	DNAH8_uc003ooe.2_Missense_Mutation_p.E2756D	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTGTGTTTGAAGTACCCAAAA	0.408000													22	70					0	0	1	0	0
FAM20C	56975	broad.mit.edu	37	7	193541	193541	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:193541C>T	uc003sip.3	+	0	573	c.342C>T	c.(340-342)gcC>gcT	p.A114A		NM_020223	NP_064608	Q8IXL6	DMP4_HUMAN	Homo sapiens family with sequence similarity 20, member C (FAM20C), mRNA.	114						extracellular region				endometrium(1)|lung(2)|urinary_tract(1)	4		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.57e-17)|Epithelial(4;1.26e-16)|all cancers(6;4.79e-14)		CGCCCGCGGCCGAGCCGGCCG	0.741000													19	15					0	0	1	0	0
PSMB1	5689	broad.mit.edu	37	6	170852793	170852793	+	Missense_Mutation	SNP	G	G	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:170852793G>T	uc011ehe.2	-	3	416	c.329C>A	c.(328-330)gCc>gAc	p.A110D	PSMB1_uc003qxq.2_Non-coding_Transcript|PSMB1_uc003qxr.3_Missense_Mutation_p.A9D	NM_002793	NP_002784	P20618	PSB1_HUMAN	Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 (PSMB1), mRNA.	110					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|interspecies interaction between organisms|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	CGTAGTCATGGCCTTATTATT	0.398000													5	57					2.0095e-06	2.26467e-06	1	1	0
FAM86DP	692099	broad.mit.edu	37	3	75472155	75472155	+	Missense_Mutation	SNP	T	T	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:75472155T>C	uc003dpp.4	-	7	1054	c.695A>G	c.(694-696)tAt>tGt	p.Y232C	FAM86DP_uc003dps.4_Non-coding_Transcript|FAM86DP_uc003dpq.4_Missense_Mutation_p.Y140C|FAM86DP_uc003dpr.4_Non-coding_Transcript					Homo sapiens family with sequence similarity 86, member D, pseudogene (FAM86DP), non-coding RNA.																		GTGCTCTCCATAGGGAAACAG	0.517000													9	574					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61111339	61111339	+	Missense_Mutation	SNP	A	A	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr11:61111339A>G	uc001nre.3	+	11	1251	c.994A>G	c.(994-996)Act>Gct	p.T332A	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Missense_Mutation_p.T262A	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	Homo sapiens dihydroxyacetone kinase 2 homolog (S. cerevisiae) (DAK), mRNA.	332	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						TGCTGAAACCACTGCAGCAGC	0.627000													15	30					0	0	1	0	0
MBNL1	4154	broad.mit.edu	37	3	152163262	152163262	+	Silent	SNP	C	C	T			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:152163262C>T	uc003ezm.3	+	3	1530	c.741C>T	c.(739-741)atC>atT	p.I247I	MBNL1_uc003ezh.3_Silent_p.I247I|MBNL1_uc003ezi.3_Silent_p.I247I|MBNL1_uc003ezj.3_Silent_p.I190I|MBNL1_uc003ezl.3_Silent_p.I247I|MBNL1_uc003ezp.3_Silent_p.I247I|MBNL1_uc003ezn.3_Silent_p.I179I|MBNL1_uc003ezo.3_Silent_p.I179I|MBNL1_uc010hvp.3_Silent_p.I155I	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	Homo sapiens muscleblind-like (Drosophila) (MBNL1), transcript variant 3, mRNA.	247					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AAGCCAAGATCAAGGCTGCCC	0.507000													34	95					0	0	1	0	0
C1orf112	55732	broad.mit.edu	37	1	169798424	169798424	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:169798424delT	uc001ggq.3	+	12	1848	c.1148delT	c.(1147-1149)gttfs	p.V383fs	C1orf112_uc001ggj.3_Non-coding_Transcript|C1orf112_uc001ggp.3_Frame_Shift_Del_p.V383fs|C1orf112_uc009wvt.3_Frame_Shift_Del_p.V60fs|C1orf112_uc010plu.1_Frame_Shift_Del_p.F311fs|C1orf112_uc009wvu.1_Frame_Shift_Del_p.V259fs|C1orf112_uc001ggr.3_Frame_Shift_Del_p.V248fs|C1orf112_uc010plv.2_Frame_Shift_Del_p.V325fs	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	Homo sapiens chromosome 1 open reading frame 112 (C1orf112), mRNA.	383								p.A382V(1)|p.V383I(1)		breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCAAAGCCGTTTTCTACAGT	0.368													29	82	---	---	---	---					
C1orf96	126731	broad.mit.edu	37	1	229461075	229461076	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr1:229461075_229461076delAG	uc001htl.4	-	3	797_798	c.719_720delCT	c.(718-720)tctfs	p.S240fs	C1orf96_uc009xfc.3_Non-coding_Transcript	NM_145257	NP_660300	Q6IQ19	CA096_HUMAN	Homo sapiens chromosome 1 open reading frame 96 (C1orf96), mRNA.	240						centrosome				breast(1)|endometrium(1)|large_intestine(4)|lung(3)	9	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				CCACATCCACAGAGTGAGCTCG	0.441													32	70	---	---	---	---					
IL1R2	7850	broad.mit.edu	37	2	102638648	102638649	+	Splice_Site	INS	-	-	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:102638648_102638649insA	uc002tbm.3	+	6	918	c.689_splice	c.e6-1	p.K230_splice	IL1R2_uc002tbn.3_Splice_Site_p.K230_splice|IL1R2_uc002tbo.1_Splice_Site_p.K230_splice	NM_004633	NP_775465	P27930	IL1R2_HUMAN	Homo sapiens interleukin 1 receptor, type II (IL1R2), transcript variant 1, mRNA.	230					immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	ATCTTTCTCAGAAAAAAAAGAA	0.441													8	346	---	---	---	---					
KBTBD10	10324	broad.mit.edu	37	2	170382094	170382096	+	Splice_Site	DEL	GGT	GGT	-	rs112795676		TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:170382094_170382096delGGT	uc002ueu.1	+	6	1787	c.1710_splice	c.e6-1	p.K570_splice	KBTBD10_uc010zdh.1_Splice_Site_p.K508_splice	NM_006063	NP_006054	O60662	KBTBA_HUMAN	Homo sapiens kelch repeat and BTB (POZ) domain containing 10 (KBTBD10), mRNA.	570					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|urinary_tract(1)	19						TCCTCCATCAGGTATGAAGATGA	0.379													8	58	---	---	---	---					
KBTBD10	10324	broad.mit.edu	37	2	170382098	170382107	+	Frame_Shift_Del	DEL	TGAAGATGAT	TGAAGATGAT	-	rs144510735		TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr2:170382098_170382107delTGAAGATGAT	uc002ueu.1	+	5	1790_1799	c.1713_1722delTGAAGATGAT	c.(1711-1722)tatgaagatgatfs	p.Y571fs	KBTBD10_uc010zdh.1_Frame_Shift_Del_p.Y509fs	NM_006063	NP_006054	O60662	KBTBA_HUMAN	Homo sapiens kelch repeat and BTB (POZ) domain containing 10 (KBTBD10), mRNA.	571					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|urinary_tract(1)	19						CCATCAGGTATGAAGATGATAAAAAAGAAT	0.367													8	61	---	---	---	---					
SATB1	6304	broad.mit.edu	37	3	18391133	18391135	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:18391133_18391135delCTG	uc003cbh.3	-	10	3554_3556	c.1819_1821delCAG	c.(1819-1821)cagdel	p.Q607del	SATB1_uc003cbi.3_In_Frame_Del_p.Q639del|SATB1_uc003cbj.3_In_Frame_Del_p.Q607del	NM_002971	NP_002962	Q01826	SATB1_HUMAN	Homo sapiens SATB homeobox 1 (SATB1), transcript variant 1, mRNA.	607	Poly-Gln.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	PML body|nuclear matrix	double-stranded DNA binding|sequence-specific DNA binding	p.Q606R(1)		NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GCGGCGGTGCctgctgctgctgc	0.606													9	49	---	---	---	---					
DLEC1	9940	broad.mit.edu	37	3	38101279	38101280	+	In_Frame_Ins	INS	-	-	CAT			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:38101279_38101280insCAT	uc003chp.1	+	2	630_631	c.609_610insCAT	c.(607-612)insCAT	p.205_206insH	DLEC1_uc003cho.1_In_Frame_Ins_p.205_206insH|DLEC1_uc010hgv.1_In_Frame_Ins_p.205_206insH|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007337	NP_031363	Q9Y238	DLEC1_HUMAN	Homo sapiens deleted in lung and esophageal cancer 1 (DLEC1), transcript variant DLEC1-S3, mRNA.	205					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TGCTACGGAAACATCATTTGAT	0.465													39	50	---	---	---	---					
LIMD1	8994	broad.mit.edu	37	3	45714309	45714327	+	Splice_Site	DEL	ACAAGTAAGAAGGGATGGG	ACAAGTAAGAAGGGATGGG	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr3:45714309_45714327delACAAGTAAGAAGGGATGGG	uc003coq.3	+	5	1821	c.1772_splice	c.e5+1	p.K591_splice		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	Homo sapiens LIM domains containing 1 (LIMD1), mRNA.	591	LIM zinc-binding 2.|Necessary for nuclear localization.				cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	RNA-induced silencing complex|cytoplasmic mRNA processing body|nucleus	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		CGAGATTACCACAAGTAAGAAGGGATGGGAGCAGACAGG	0.530													7	54	---	---	---	---					
CXCL1	2919	broad.mit.edu	37	4	74735703	74735704	+	Frame_Shift_Ins	INS	-	-	C			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:74735703_74735704insC	uc003hhh.2	+	2	384_385	c.305_306insC	c.(304-306)aacfs	p.N102fs		NM_001511	NP_001502	P09341	GROA_HUMAN	Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA.	102					G-protein coupled receptor protein signaling pathway|actin cytoskeleton organization|cell proliferation|chemotaxis|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity			lung(2)	2	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			AAGATGCTGAACAGGTGAGTTA	0.475													9	159	---	---	---	---					
ANTXR2	118429	broad.mit.edu	37	4	80976344	80976344	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr4:80976344delC	uc003hlz.4	-	5	1278	c.515delG	c.(514-516)agtfs	p.S172fs	ANTXR2_uc003hly.4_Frame_Shift_Del_p.S172fs|ANTXR2_uc003hlx.1_Non-coding_Transcript|ANTXR2_uc010ijn.3_Frame_Shift_Del_p.S172fs	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	Homo sapiens anthrax toxin receptor 2 (ANTXR2), transcript variant 2, mRNA.	172	VWFA.					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						ACAATAAACACTAGCCCCAAG	0.383									Juvenile Hyaline Fibromatosis				42	86	---	---	---	---					
MARCKS	4082	broad.mit.edu	37	6	114181209	114181210	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr6:114181209_114181210insA	uc003pvy.4	+	1	848_849	c.453_454insA	c.(451-456)ccgaaafs	p.P151fs		NM_002356	NP_002347	P29966	MARCS_HUMAN	Homo sapiens myristoylated alanine-rich protein kinase C substrate (MARCKS), mRNA.	151					energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding	p.K155fs*12(1)		breast(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		ACGAGACCCCGAAAAAAAAAAA	0.614													4	8	---	---	---	---					
PNPLA8	50640	broad.mit.edu	37	7	108154603	108154603	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:108154603delT	uc003vff.1	-	4	1598	c.1191delA	c.(1189-1191)aaafs	p.K397fs	PNPLA8_uc003vfi.1_Frame_Shift_Del_p.K297fs|PNPLA8_uc003vfh.1_Frame_Shift_Del_p.K397fs|PNPLA8_uc003vfj.1_Frame_Shift_Del_p.K397fs|PNPLA8_uc003vfk.1_Frame_Shift_Del_p.K297fs	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	Homo sapiens patatin-like phospholipase domain containing 8 (PNPLA8), transcript variant 1, mRNA.	397					fatty acid metabolic process|lipid catabolic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						CAGCCACTCCTTTTCCTTCAG	0.353													23	83	---	---	---	---					
CHCHD3	54927	broad.mit.edu	37	7	132570441	132570442	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr7:132570441_132570442insG	uc022alw.1	-	5	579_580	c.448_449insC	c.(448-450)ctgfs	p.L150fs	CHCHD3_uc003vre.3_Frame_Shift_Ins_p.L145fs|CHCHD3_uc010lmi.3_Non-coding_Transcript	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 3 (CHCHD3), mRNA.	145					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold	p.E150D(1)		endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	7						CAGTCTAGCCAGCTGTTCTTTG	0.332													15	49	---	---	---	---					
SHB	6461	broad.mit.edu	37	9	37919918	37919918	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr9:37919918delC	uc004aax.3	-	5	1998	c.1430delG	c.(1429-1431)agtfs	p.S477fs		NM_003028	NP_003019	Q15464	SHB_HUMAN	Homo sapiens Src homology 2 domain containing adaptor protein B (SHB), mRNA.	477	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TTCCGGGACACTGTCGAACGG	0.517													35	106	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89692845	89692845	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr10:89692845delA	uc001kfb.3	+	4	1361	c.329delA	c.(328-330)caafs	p.Q110fs	PTEN_uc021pvw.1_Non-coding_Transcript	NM_000314	NP_000305	P60484	PTEN_HUMAN	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	110	Phosphatase tensin-type.				T cell receptor signaling pathway|activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development	PML body|cytosol|internal side of plasma membrane	PDZ domain binding|anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.Q110*(4)|p.L108_D109del(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.Q110fs*13(1)|p.D109fs*6(1)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GATCTTGACCAATGGCTAAGT	0.398		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			59	155	---	---	---	---					
DDX12P	440081	broad.mit.edu	37	12	9573305	9573305	+	RNA	DEL	G	G	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:9573305delG	uc021qut.1	-	10		c.2093delC			DDX12P_uc001qvx.4_Intron|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.																		gagggagggagggagCCCCCA	0.582													12	22	---	---	---	---					
SIRT4	23409	broad.mit.edu	37	12	120750516	120750517	+	Frame_Shift_Del	DEL	AA	AA	-	rs16950058	byFrequency	TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:120750516_120750517delAA	uc001tyc.3	+	2	814_815	c.755_756delAA	c.(754-756)gaafs	p.E252fs		NM_012240	NP_036372	Q9Y6E7	SIRT4_HUMAN	Homo sapiens sirtuin 4 (SIRT4), mRNA.	252	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	NAD+ ADP-ribosyltransferase activity|NAD+ binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGTGTAAAAGAAGCCGACTCCC	0.525													29	76	---	---	---	---					
DHX37	57647	broad.mit.edu	37	12	125465270	125465272	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-B1-A657-01A-11D-A31X-10	TCGA-B1-A657-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c22d5cb0-397b-480a-97ae-4bf07e07c1f0	86a94d68-d695-416e-a19a-d1f1d0952902	g.chr12:125465270_125465272delCTC	uc001ugy.3	-	3	601_603	c.502_504delGAG	c.(502-504)gagdel	p.E168del		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 37 (DHX37), mRNA.	168							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.E168delE(6)		breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCGATTCCGActcctcctcctcc	0.690													7	37	---	---	---	---					
