Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SUSD4	55061	broad.mit.edu	37	1	223438095	223438095	+	Missense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr1:223438095G>A	uc001hnx.3	-	3	1235	c.601C>T	c.(601-603)Ccg>Tcg	p.P201S	SUSD4_uc001hny.4_Missense_Mutation_p.P201S|SUSD4_uc010puw.2_Missense_Mutation_p.P41S|SUSD4_uc001hnz.2_Missense_Mutation_p.P201S|SUSD4_uc010pux.1_Missense_Mutation_p.P130S	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	Homo sapiens sushi domain containing 4 (SUSD4), transcript variant 1, mRNA.	201	Sushi 3.					integral to membrane		p.P201Q(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GTCCCCACCGGGAAGGAGGTC	0.498000													12	54					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847891	123847891	+	Missense_Mutation	SNP	C	C	T	rs114187251	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:123847891C>T	uc001pzm.1	-	0	508	c.508G>A	c.(508-510)Gct>Act	p.A170T		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily S, member 1 (OR10S1), mRNA.	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H169H(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGGATTGCAGCGTGCGTGGCA	0.567000													9	120					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785315	134785315	+	Silent	SNP	G	G	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:134785315G>C	uc003law.4	-	1	516	c.315C>G	c.(313-315)gtC>gtG	p.V105V	C5orf20_uc003lav.3_5'Flank|TIFAB_uc021ydu.1_Silent_p.V105V	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	Homo sapiens TRAF-interacting protein with forkhead-associated domain, family member B (TIFAB), mRNA.	105										breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTGAGAAGGAGACCCTGTTGA	0.577000													20	90					0	0	1	0	0
METAP2	10988	broad.mit.edu	37	12	95907438	95907438	+	Missense_Mutation	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:95907438A>G	uc001tec.3	+	10	1329	c.1195A>G	c.(1195-1197)Aca>Gca	p.T399A	METAP2_uc010suv.2_Missense_Mutation_p.T376A|METAP2_uc001tef.3_Missense_Mutation_p.T376A|METAP2_uc001tee.3_Non-coding_Transcript	NM_006838	NP_006829	P50579	AMPM2_HUMAN	Homo sapiens methionyl aminopeptidase 2 (METAP2), mRNA.	399					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|large_intestine(2)|lung(7)|prostate(1)	13					L-Methionine(DB00134)	GCTTCCAAGAACAAAACACTT	0.418000													19	54					0	0	1	0	0
CBLL1	79872	broad.mit.edu	37	7	107398636	107398636	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr7:107398636C>T	uc003veq.3	+	5	819	c.489C>T	c.(487-489)ctC>ctT	p.L163L	CBLL1_uc011kme.2_Silent_p.L42L|CBLL1_uc011kmf.2_Silent_p.L162L	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1 (CBLL1), transcript variant 1, mRNA.	163					cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						GAGGTTCTCTCTTCATGTGTA	0.398000													25	94					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82879804	82879804	+	Silent	SNP	A	A	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:82879804A>T	uc001ozx.4	+	7	2772	c.2427A>T	c.(2425-2427)ccA>ccT	p.P809P	PCF11_uc010rsu.1_Silent_p.P940P	NM_015885	NP_056969	O94913	PCF11_HUMAN	Homo sapiens PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae) (PCF11), mRNA.	809	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TTGAGGGGCCACAAGGTCAGC	0.562000													4	151					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132171207	132171207	+	Missense_Mutation	SNP	A	A	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:132171207A>C	uc011ecf.2	+	2	411	c.391A>C	c.(391-393)Aac>Cac	p.N131H		NM_006208	NP_006199	P22413	ENPP1_HUMAN	Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), mRNA.	131	SMB 1.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TGAGCTTGGAAACTGCTGTTT	0.423000													33	85					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167266219	167266219	+	Missense_Mutation	SNP	G	G	A	rs6760593		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr2:167266219G>A	uc002udu.2	-	23	4068	c.3938C>T	c.(3937-3939)gCg>gTg	p.A1313V	SCN7A_uc010fpm.2_Non-coding_Transcript	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	Homo sapiens sodium channel, voltage-gated, type VII, alpha (SCN7A), transcript variant 1, mRNA.	1313			A -> V (in dbSNP:rs6760593).		muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AATGTTCCACGCAATGGTGAA	0.308000													4	100					0	0	1	0	0
C4orf50	389197	broad.mit.edu	37	4	5969172	5969172	+	RNA	SNP	G	G	A	rs115562230	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:5969172G>A	uc003git.2	-	4		c.1724C>T						Q6ZRC1	CD050_HUMAN	Homo sapiens cDNA FLJ46481 fis, clone THYMU3025772.											breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						CAGACTTGACGTCCAGGTGGT	0.507000													4	82					0	0	1	0	0
TTC28	23331	broad.mit.edu	37	22	28504235	28504235	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr22:28504235G>T	uc003adp.4	-	6	1740	c.1598C>A	c.(1597-1599)gCg>gAg	p.A533E		NM_001145418	NP_001138890	Q96AY4	TTC28_HUMAN	Homo sapiens tetratricopeptide repeat domain 28 (TTC28), mRNA.	533							binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)	12						GTATTTGACCGCCTGGTCGTA	0.592000													6	62					3.09899e-07	3.70367e-07	1	1	0
DNAJB9	4189	broad.mit.edu	37	7	108212287	108212287	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr7:108212287G>A	uc003vfn.3	+	1	486	c.117G>A	c.(115-117)gaG>gaA	p.E39E	THAP5_uc003vfl.3_5'Flank|THAP5_uc003vfm.3_5'Flank	NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 9 (DNAJB9), mRNA.	39	J.				ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						CGGCATCAGAGCGCCAAATCA	0.403000													34	78					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118490	118490	+	RNA	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrGL000205.1:118490G>T	uc002kgk.4	+	0		c.1868G>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		AGCAGAGAATGCCGGAAGGTA	0.463000													4	29					2.56e-06	2.95153e-06	1	1	0
APBB2	323	broad.mit.edu	37	4	40818110	40818110	+	Nonstop_Mutation	SNP	T	T	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:40818110T>A	uc003gvn.3	-	17	2909	c.2279A>T	c.(2278-2280)tAg>tTg	p.*760L	APBB2_uc010ifu.3_Nonstop_Mutation_p.*331L|APBB2_uc003gvl.3_Nonstop_Mutation_p.*759L|APBB2_uc003gvm.3_Nonstop_Mutation_p.*737L|APBB2_uc003gvk.3_Nonstop_Mutation_p.*211L|APBB2_uc021xnt.1_Nonstop_Mutation_p.*211L	NM_004307	NP_004298	Q92870	APBB2_HUMAN	Homo sapiens amyloid beta (A4) precursor protein-binding, family B, member 2 (APBB2), transcript variant 1, mRNA.	0					cell cycle arrest|intracellular signal transduction|negative regulation of S phase of mitotic cell cycle|negative regulation of cell growth|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						CATGTGCAGCTATGGCATTTC	0.458000													19	62					0	0	1	0	0
CLK2P	1197	broad.mit.edu	37	7	23625408	23625408	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr7:23625408T>C	uc003swk.2	-	0	739	c.89A>G	c.(88-90)aAc>aGc	p.N30S						Homo sapiens CDC-like kinase 2, pseudogene (CLK2P), non-coding RNA.																		GGGCAGGTGGTTGTTGTCTTT	0.527000													3	145					0	0	1	0	0
HIST1H3J	8356	broad.mit.edu	37	6	27858516	27858516	+	Missense_Mutation	SNP	T	T	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:27858516T>G	uc003nka.3	-	0	55	c.55A>C	c.(55-57)Aag>Cag	p.K19Q	HIST1H2BO_uc003nkc.1_5'Flank	NM_003535	NP_066298	P68431	H31_HUMAN	Homo sapiens histone cluster 1, H3j (HIST1H3J), mRNA.	19					S phase|blood coagulation|nucleosome assembly|regulation of gene silencing	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	8						GCCAGCTGCTTCCGCGGTGCC	0.617000													19	48					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115917414	115917414	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr10:115917414G>A	uc001lbb.1	-	2	1310	c.658C>T	c.(658-660)Cag>Tag	p.Q220*	C10orf118_uc009xye.1_Non-coding_Transcript|C10orf118_uc001lbc.1_Nonsense_Mutation_p.Q220*	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	Homo sapiens chromosome 10 open reading frame 118 (C10orf118), mRNA.	220										NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		AAGAGCTCCTGATGCTTCTTA	0.274000													5	12					0	0	1	0	0
PDLIM4	8572	broad.mit.edu	37	5	131602211	131602211	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:131602211C>T	uc003kwo.3	+	2	377	c.300C>T	c.(298-300)caC>caT	p.H100H	BC030525_uc003kwm.4_Intron|PDLIM4_uc003kwn.3_Silent_p.H100H|PDLIM4_uc003kwp.3_Silent_p.H100H	NM_003687	NP_003678	P50479	PDLI4_HUMAN	Homo sapiens PDZ and LIM domain 4 (PDLIM4), transcript variant 1, mRNA.	100							protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|urinary_tract(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCAGGCACACAGGATCCACA	0.592000													56	129					0	0	1	0	0
SLC22A4	6583	broad.mit.edu	37	5	131647952	131647952	+	Silent	SNP	A	A	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:131647952A>C	uc003kwq.3	+	1	657	c.492A>C	c.(490-492)tcA>tcC	p.S164S	SLC22A4_uc010jdq.1_Non-coding_Transcript|LOC553103_uc021ydj.1_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	Homo sapiens solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (SLC22A4), mRNA.	164					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|PDZ domain binding|carnitine transporter activity|cation:cation antiporter activity|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GGCAGCTGTCAGACAGGTAAG	0.572000													13	32					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	726471	726471	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:726471G>T	uc001lqt.3	+	18	2168	c.1921G>T	c.(1921-1923)Gcc>Tcc	p.A641S	EPS8L2_uc001lqu.3_Missense_Mutation_p.A641S|EPS8L2_uc010qwk.2_Missense_Mutation_p.A657S|EPS8L2_uc001lqv.3_Missense_Mutation_p.A596S|EPS8L2_uc001lqw.3_Missense_Mutation_p.A253S|EPS8L2_uc001lqx.3_Missense_Mutation_p.A253S|EPS8L2_uc001lqy.3_Missense_Mutation_p.A149S	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	Homo sapiens EPS8-like 2 (EPS8L2), mRNA.	641						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAAGCCAAGGCCTTCAGCCC	0.756000													6	54					0.00198382	0.00204647	1	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497770	1497770	+	Missense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr8:1497770G>A	uc003wpl.3	+	1	1008	c.911G>A	c.(910-912)cGc>cAc	p.R304H	DLGAP2_uc003wpm.3_Missense_Mutation_p.R304H	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	Homo sapiens discs, large (Drosophila) homolog-associated protein 2 (DLGAP2), mRNA.	383					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAGGCCTACCGCAAGAGCTCG	0.672000													4	107					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164761953	164761953	+	Missense_Mutation	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr1:164761953C>T	uc001gct.3	+	2	951	c.488C>T	c.(487-489)aCg>aTg	p.T163M	PBX1_uc010pku.2_Missense_Mutation_p.T163M|PBX1_uc001gcs.3_Missense_Mutation_p.T163M|PBX1_uc010pkv.2_Missense_Mutation_p.T80M|PBX1_uc010pkw.1_Missense_Mutation_p.T53M	NM_002585	NP_002576	P40424	PBX1_HUMAN	Homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript variant 1, mRNA.	163					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						ATCTACCATACGGAGCTGGAG	0.577000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								21	22					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48536646	48536646	+	Silent	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:48536646A>G	uc003gyh.1	-	48	7226	c.6621T>C	c.(6619-6621)agT>agC	p.S2207S	FRYL_uc003gyg.1_Silent_p.S903S|FRYL_uc003gyi.1_Silent_p.S1095S|FRYL_uc003gyj.1_Silent_p.S502S	NM_015030	NP_055845	O94915	FRYL_HUMAN	Homo sapiens FRY-like (FRYL), mRNA.	2207					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GACTCAATAGACTATAAATAA	0.333000													7	42					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825368	95825368	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:95825368C>T	uc001pfw.1	-	1	3112	c.1827G>A	c.(1825-1827)caG>caA	p.Q609Q		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	609					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgctgctgctgctgttgct	0.542000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								7	66					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1477990	1477990	+	Splice_Site	SNP	C	C	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr7:1477990C>G	uc003skj.4	-	11	2270	c.2123_splice	c.e11-1	p.G708_splice	MICALL2_uc003ski.4_Splice_Site_p.G195_splice	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	Homo sapiens MICAL-like 2 (MICALL2), transcript variant 1, mRNA.	708						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		AAGGGTCTCCCTGGAGAAGGA	0.672000													30	93					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794425	30794425	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:30794425G>A	uc002dzs.1	-	2	1432	c.1224C>T	c.(1222-1224)ggC>ggT	p.G408G		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	Homo sapiens zinc finger protein 629 (ZNF629), mRNA.	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			TGAAGCTCTTGCCGCACTCTG	0.652000													43	105					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294936	103294936	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrX:103294936G>T	uc004els.2	+	0	421	c.393G>T	c.(391-393)aaG>aaT	p.K131N		NM_001164416	NP_001157888			Homo sapiens H2B histone family, member M (H2BFM), mRNA.											endometrium(1)|lung(1)|ovary(1)	3						AGATGGGCAAGCTCGCCGAGG	0.632000													5	58					1.23904e-05	1.37984e-05	1	1	0
ID1	3397	broad.mit.edu	37	20	30193533	30193533	+	Missense_Mutation	SNP	G	G	C	rs145878183	byFrequency	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr20:30193533G>C	uc002wwg.2	+	0	448	c.343G>C	c.(343-345)Gtt>Ctt	p.V115L	ID1_uc002wwh.2_Missense_Mutation_p.V115L|MIR3193_uc021wbt.1_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1), transcript variant 1, mRNA.	115					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			endometrium(2)|ovary(1)|pancreas(1)	4	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GGAATCCGAAGTTGGAACCCC	0.637000													4	166					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5754739	5754739	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:5754739G>A	uc003gil.1	+	8	1459	c.1275G>A	c.(1273-1275)caG>caA	p.Q425Q	EVC_uc003gim.1_Non-coding_Transcript	NM_153717	NP_714928	P57679	EVC_HUMAN	Homo sapiens Ellis van Creveld syndrome (EVC), mRNA.	425					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TCACGCAGCAGCACAAGGCCT	0.692000													33	82					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64217047	64217047	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr15:64217047T>C	uc002amr.3	-	8	857	c.826A>G	c.(826-828)Atc>Gtc	p.I276V	DAPK2_uc010uim.2_Non-coding_Transcript	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	Homo sapiens death-associated protein kinase 2 (DAPK2), mRNA.	276	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		GCCTCTTGGATTGTGAGCCGT	0.532000													4	108					0	0	1	0	0
BCRP3	644165	broad.mit.edu	37	22	25045855	25045855	+	Silent	SNP	G	G	A	rs738818	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr22:25045855G>A	uc011ajv.2	+	5	936	c.579G>A	c.(577-579)agG>agA	p.R193R	POM121L10P_uc003abc.2_Intron					Homo sapiens breakpoint cluster region pseudogene 3 (BCRP3), non-coding RNA.																		GGTCAATAAGGTGTCCCTGCA	0.632000													5	153					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475890	120475890	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr9:120475890T>C	uc004bjz.3	+	2	1775	c.1484T>C	c.(1483-1485)cTg>cCg	p.L495P	TLR4_uc004bkb.3_Missense_Mutation_p.L295P|TLR4_uc004bka.3_Missense_Mutation_p.L455P	NM_138554	NP_612564	O00206	TLR4_HUMAN	Homo sapiens toll-like receptor 4 (TLR4), transcript variant 1, mRNA.	495					I-kappaB phosphorylation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T-helper 1 type immune response|Toll signaling pathway|activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|innate immune response|intestinal epithelial structure maintenance|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity	p.L495P(2)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTCACAGAGCTGAGAAACTTG	0.448000													3	52					0	0	1	0	0
DTNBP1	84062	broad.mit.edu	37	6	15523339	15523339	+	Missense_Mutation	SNP	C	C	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:15523339C>G	uc003nbm.3	-	9	1112	c.923G>C	c.(922-924)cGg>cCg	p.R308P	DTNBP1_uc003nbl.3_Missense_Mutation_p.R227P	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	Homo sapiens dystrobrevin binding protein 1 (DTNBP1), transcript variant 1, mRNA.	308	Dysbindin.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	BLOC-1 complex|axon part|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			ACTGATGTCCCGGGTGGCCGA	0.567000									Hermansky-Pudlak syndrome				25	133					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48541577	48541577	+	Splice_Site	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr17:48541577A>G	uc010wmm.1	+	11	1318	c.1214_splice	c.e11-2	p.G405_splice	ACSF2_uc002iqu.2_Splice_Site_p.G380_splice|ACSF2_uc010wml.1_Splice_Site_p.G337_splice|ACSF2_uc010wmn.1_Splice_Site_p.G367_splice|ACSF2_uc010wmo.1_Splice_Site_p.G220_splice	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	Homo sapiens acyl-CoA synthetase family member 2 (ACSF2), mRNA.	380					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCTCTGATTCAGGTGTCATTG	0.547000													35	60					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95825356	95825356	+	Silent	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:95825356T>C	uc001pfw.1	-	1	3124	c.1839A>G	c.(1837-1839)caA>caG	p.Q613Q		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	613					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgttgctgttgctgctgct	0.542000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								6	67					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47170779	47170779	+	Missense_Mutation	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:47170779C>T	uc001rpi.2	-	12	1481	c.1082G>A	c.(1081-1083)cGg>cAg	p.R361Q	SLC38A4_uc001rpj.2_Missense_Mutation_p.R361Q	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	Homo sapiens solute carrier family 38, member 4 (SLC38A4), transcript variant 1, mRNA.	361					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					CATTTTTCTCCGGGACCGACT	0.358000													15	42					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95204298	95204298	+	Missense_Mutation	SNP	C	C	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:95204298C>G	uc003htb.4	+	21	2936	c.2759C>G	c.(2758-2760)aCc>aGc	p.T920S	SMARCAD1_uc003htc.4_Missense_Mutation_p.T918S|SMARCAD1_uc003htd.4_Missense_Mutation_p.T920S|SMARCAD1_uc010ila.3_Missense_Mutation_p.T783S|SMARCAD1_uc011cdw.2_Missense_Mutation_p.T488S	NM_001128430	NP_001121902	Q9H4L7	SMRCD_HUMAN	Homo sapiens SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 (SMARCAD1), transcript variant 2, mRNA.	918	Helicase C-terminal.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GAGTTTAATACCGATATGGAT	0.289000													3	76					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31087650	31087650	+	Missense_Mutation	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:31087650A>G	uc002eap.3	+	1	294	c.5A>G	c.(4-6)gAg>gGg	p.E2G	ZNF668_uc010caf.3_5'Flank|ZNF668_uc002eao.3_5'Flank|ZNF646_uc021tgu.1_Missense_Mutation_p.E2G	NM_014699	NP_055514	O15015	ZN646_HUMAN	Homo sapiens zinc finger protein 646 (ZNF646), mRNA.	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						TGCCCCATGGAGGACACACCC	0.622000													3	86					0	0	1	0	0
TMOD4	29765	broad.mit.edu	37	1	151146999	151146999	+	Nonsense_Mutation	SNP	T	T	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr1:151146999T>A	uc001exc.4	-	2	338	c.148A>T	c.(148-150)Aga>Tga	p.R50*	TMOD4_uc001exb.3_5'Flank|TMOD4_uc001exd.3_Non-coding_Transcript|TMOD4_uc010pct.2_Nonsense_Mutation_p.R50*	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	Homo sapiens tropomodulin 4 (muscle) (TMOD4), mRNA.	50					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCACGTTGTCTTAGTCCAGCT	0.537000													3	31					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233651899	233651899	+	Missense_Mutation	SNP	G	G	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr2:233651899G>C	uc002vtj.4	+	10	905	c.638G>C	c.(637-639)gGg>gCg	p.G213A	GIGYF2_uc010zmj.1_Missense_Mutation_p.G191A|GIGYF2_uc002vtg.2_Missense_Mutation_p.G191A|GIGYF2_uc002vti.4_Missense_Mutation_p.G191A|GIGYF2_uc002vtk.4_Missense_Mutation_p.G191A|GIGYF2_uc002vth.4_Missense_Mutation_p.G191A|GIGYF2_uc010zmk.2_Non-coding_Transcript|GIGYF2_uc010zml.1_Missense_Mutation_p.G22A	NM_001103147	NP_001096617	Q6Y7W6	PERQ2_HUMAN	Homo sapiens GRB10 interacting GYF protein 2 (GIGYF2), transcript variant 1, mRNA.	191	Arg-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ACATCAGTAGGGAGAAAGCAT	0.403000													12	61					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938841	2938841	+	Silent	SNP	C	C	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr1:2938841C>A	uc001ajz.3	+	0	796	c.591C>A	c.(589-591)ctC>ctA	p.L197L		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	Homo sapiens actin-related protein T2 (ACTRT2), mRNA.	197						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TGCAGCTGCTCCTGGCCAGCG	0.627000													57	95					2.60599e-31	3.27419e-31	1	1	0
ARMCX5	64860	broad.mit.edu	37	X	101857944	101857944	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrX:101857944G>T	uc022cbb.1	+	0	875	c.875G>T	c.(874-876)gGg>gTg	p.G292V	ARMCX5_uc004ejg.3_Missense_Mutation_p.G292V|ARMCX5_uc022caw.1_Missense_Mutation_p.G292V|ARMCX5_uc022cax.1_Missense_Mutation_p.G292V|ARMCX5-GPRASP2_uc022cay.1_Intron|ARMCX5_uc022caz.1_Missense_Mutation_p.G292V|ARMCX5_uc022cba.1_Missense_Mutation_p.G292V|ARMCX5_uc004ejh.3_Missense_Mutation_p.G292V	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	Homo sapiens armadillo repeat containing, X-linked 5 (ARMCX5), transcript variant 2, mRNA.	292							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						GAAAAGTATGGGCCTAATCCG	0.443000													3	52					0.000602214	0.000627841	1	1	0
MMP15	4324	broad.mit.edu	37	16	58074478	58074478	+	Silent	SNP	C	C	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:58074478C>A	uc002ena.3	+	4	1759	c.786C>A	c.(784-786)ggC>ggA	p.G262G		NM_002428	NP_002419	P51511	MMP15_HUMAN	Homo sapiens matrix metallopeptidase 15 (membrane-inserted) (MMP15), mRNA.	262					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding	p.L261L(1)		breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ATGAGCTGGGCCACGCGCTGG	0.602000													4	86					1.024e-07	1.23891e-07	1	1	0
CAD	790	broad.mit.edu	37	2	27462296	27462296	+	Missense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr2:27462296G>A	uc002rji.3	+	32	5513	c.5351G>A	c.(5350-5352)cGc>cAc	p.R1784H	CAD_uc010eyw.3_Missense_Mutation_p.R1721H	NM_004341	NP_004332	P27708	PYR1_HUMAN	Homo sapiens carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), mRNA.	1784	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	ATP binding|aspartate binding|aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GGCACCGTCCGCCGTGTGGTC	0.577000													4	116					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526000	7526000	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:7526000G>T	uc010sge.2	-	13	3702	c.3676C>A	c.(3676-3678)Cat>Aat	p.H1226N	CD163L1_uc001qsy.3_Missense_Mutation_p.H1216N	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	Homo sapiens CD163 molecule-like 1 (CD163L1), mRNA.	1216	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						ATGGAGATATGCGTTTTAGGA	0.522000													32	194					4.16155e-14	5.16242e-14	1	1	0
BBS7	55212	broad.mit.edu	37	4	122774226	122774226	+	Missense_Mutation	SNP	T	T	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:122774226T>A	uc003ied.3	-	7	918	c.734A>T	c.(733-735)gAc>gTc	p.D245V	BBS7_uc003iee.2_Missense_Mutation_p.D245V	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Homo sapiens Bardet-Biedl syndrome 7 (BBS7), transcript variant 1, mRNA.	245					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						GTCAAAGCTGTCAATACACAA	0.333000									Bardet-Biedl syndrome				46	104					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71509346	71509346	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr9:71509346T>C	uc004agu.3	+	7	868	c.563T>C	c.(562-564)aTg>aCg	p.M188T	PIP5K1B_uc011lrq.2_Missense_Mutation_p.M188T|PIP5K1B_uc004agv.3_Non-coding_Transcript	NM_003558	NP_003549	O14986	PI51B_HUMAN	Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, beta (PIP5K1B), transcript variant 2, mRNA.	188	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATTGTGGTGATGAACAACGTT	0.403000													42	118					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161116041	161116041	+	Silent	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:161116041T>C	uc003lyu.2	+	3	650	c.312T>C	c.(310-312)aaT>aaC	p.N104N	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 6 (GABRA6), mRNA.	104					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAGTCTGAATAATTTGATGG	0.403000										TCGA Ovarian(5;0.080)			13	48					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3123099	3123099	+	Missense_Mutation	SNP	A	A	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:3123099A>C	uc021xkv.1	+	8	1358	c.1213A>C	c.(1213-1215)Acc>Ccc	p.T405P		NM_002111	NP_002102	P42858	HD_HUMAN	Homo sapiens huntingtin (HTT), mRNA.	405					Golgi organization|establishment of mitotic spindle orientation|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	Golgi apparatus|autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TGGGCAGCTCACCGCTGCTAA	0.547000													3	105					0	0	1	0	0
FBRSL1	57666	broad.mit.edu	37	12	133102403	133102403	+	Silent	SNP	C	C	T	rs61529021	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:133102403C>T	uc001ukf.3	+	2	573	c.573C>T	c.(571-573)ctC>ctT	p.L191L		NM_001142641	NP_001136113	Q9HCM7	FBSL_HUMAN	Homo sapiens fibrosin-like 1 (FBRSL1), mRNA.	191										central_nervous_system(2)|endometrium(1)|stomach(1)	4						GGGACCCGCTCAGCGATGTGA	0.701000													5	137					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11134286	11134286	+	Silent	SNP	C	C	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:11134286C>G	uc010dxp.3	+	20	3312	c.2952C>G	c.(2950-2952)gtC>gtG	p.V984V	SMARCA4_uc010dxo.3_Silent_p.V984V|SMARCA4_uc002mqf.4_Silent_p.V984V|SMARCA4_uc002mqg.1_Silent_p.V984V|SMARCA4_uc010dxq.3_Silent_p.V984V|SMARCA4_uc010dxr.3_Silent_p.V984V|SMARCA4_uc002mqj.4_Silent_p.V984V|SMARCA4_uc010dxs.3_Silent_p.V984V|SMARCA4_uc010dxt.1_Silent_p.V204V|SMARCA4_uc002mqh.4_Silent_p.V107V|SMARCA4_uc002mqi.1_Silent_p.V187V	NM_001128844	NP_003063	P51532	SMCA4_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 2, mRNA.	984					chromatin remodeling|negative regulation of S phase of mitotic cell cycle|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|WINAC complex|nBAF complex|npBAF complex|nuclear chromatin	ATP binding|DNA binding|DNA-dependent ATPase activity|androgen receptor binding|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGAAGGAAGTCGAGGCCCAGT	0.597000			"""F, N, Mis"""		NSCLC								19	83					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24771576	24771576	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr8:24771576C>T	uc003xed.4	+	0	303	c.270C>T	c.(268-270)ccC>ccT	p.P90P	NEFM_uc011lac.1_Silent_p.P90P|NEFM_uc010lue.3_5'Flank|AK308605_uc010luc.2_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	Homo sapiens neurofilament, medium polypeptide (NEFM), transcript variant 1, mRNA.	90	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GCTCCGGACCCGGCGGCGACT	0.657000													4	115					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38699223	38699223	+	Missense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr22:38699223G>A	uc003avj.3	-	2	368	c.107C>T	c.(106-108)gCc>gTc	p.A36V	CSNK1E_uc003avk.3_Missense_Mutation_p.A36V|CSNK1E_uc003avm.2_Missense_Mutation_p.A36V|CSNK1E_uc010gxm.2_Non-coding_Transcript	NM_152221	NP_689407	P49674	KC1E_HUMAN	Homo sapiens casein kinase 1, epsilon (CSNK1E), transcript variant 1, mRNA.	36	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					CAGCTTGATGGCGACTTCCTC	0.632000													3	36					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553994	140553994	+	Silent	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:140553994G>T	uc003lit.3	+	0	1752	c.1578G>T	c.(1576-1578)gcG>gcT	p.A526A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	Homo sapiens protocadherin beta 7 (PCDHB7), mRNA.	526	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A526A(2)|p.A526S(1)|p.Q525Q(1)|p.A526E(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGCAGGCGTTCGAGTTCC	0.706000													5	241					1.12685e-05	1.26933e-05	1	1	0
ACPL2	92370	broad.mit.edu	37	3	141011642	141011642	+	Silent	SNP	C	C	T	rs145988315	byFrequency	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr3:141011642C>T	uc003etu.3	+	7	1337	c.1038C>T	c.(1036-1038)ctC>ctT	p.L346L	ACPL2_uc003etv.3_Silent_p.L346L|ACPL2_uc011bna.2_Silent_p.L308L|ACPL2_uc011bnb.2_Silent_p.L329L	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	Homo sapiens acid phosphatase-like 2 (ACPL2), transcript variant 1, mRNA.	346						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						GGTATTCTCTCCTGGGTGCCC	0.522000													4	104					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58601915	58601915	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:58601915T>C	uc001nnd.4	-	5	1003	c.872A>G	c.(871-873)aAg>aGg	p.K291R	GLYATL2_uc009ymq.3_Missense_Mutation_p.K291R	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	Homo sapiens glycine-N-acyltransferase-like 2 (GLYATL2), mRNA.	291						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	ACAATATTTCTTGGGGGTGCA	0.363000													9	23					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50147868	50147868	+	Silent	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr3:50147868T>C	uc003cyg.3	+	15	1510	c.1335T>C	c.(1333-1335)ccT>ccC	p.P445P	RBM5_uc011bdj.2_Silent_p.P389P|RBM5_uc011bdk.2_Silent_p.P273P|RBM5_uc003cyh.3_5'Flank	NM_005778	NP_005769	P52756	RBM5_HUMAN	Homo sapiens RNA binding motif protein 5 (RBM5), transcript variant 1, mRNA.	445	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCGCTTCCCCTACTGGTGTAG	0.458000													27	81					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64808728	64808728	+	Silent	SNP	C	C	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:64808728C>A	uc001ssb.3	+	2	608	c.102C>A	c.(100-102)gcC>gcA	p.A34A	XPOT_uc009zqm.2_5'UTR	NM_007235	NP_009166	O43592	XPOT_HUMAN	Homo sapiens exportin, tRNA (nuclear export receptor for tRNAs) (XPOT), mRNA.	34	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		CCCCAGATGCCTGGCAGGTGT	0.388000													5	23					0.000602214	0.000627841	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38875811	38875811	+	Missense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:38875811G>A	uc021yzh.1	+	63	9537	c.9428G>A	c.(9427-9429)cGc>cAc	p.R3143H	DNAH8_uc003ooe.2_Missense_Mutation_p.R2926H|LOC100131047_uc003oof.2_Intron	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GAGCTACCTCGCCATCCTCCT	0.383000													4	54					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70618524	70618524	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrX:70618524G>A	uc004dzu.4	+	23	3771	c.3720G>A	c.(3718-3720)aaG>aaA	p.K1240K	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.4_Silent_p.K1261K|TAF1_uc004dzv.4_Silent_p.K414K	NM_138923	NP_620278	P21675	TAF1_HUMAN	Homo sapiens TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (TAF1), transcript variant 2, mRNA.	1240					G1 phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|TBP-class protein binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				ACCAGGAAAAGGAGAAGCTTA	0.458000													62	41					0	0	1	0	0
NME6	10201	broad.mit.edu	37	3	48336157	48336157	+	Silent	SNP	T	T	C	rs148416956		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr3:48336157T>C	uc003cso.3	-	5	601	c.555A>G	c.(553-555)gtA>gtG	p.V185V	NME6_uc011bbh.2_Nonstop_Mutation_p.*164W|NME6_uc010hju.3_Silent_p.V79V|NME6_uc003csp.4_Silent_p.V177V|NME6_uc011bbi.2_Silent_p.V110V	NM_005793	NP_005784	O75414	NDK6_HUMAN	Homo sapiens non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) (NME6), mRNA.	177					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process|anti-apoptosis|apoptosis|negative regulation of cell growth|negative regulation of mitosis	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			breast(1)|large_intestine(5)	6				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CTGTTCCAGCTACATAGTGGA	0.537000													3	93					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86565821	86565821	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:86565821G>A	uc002fjn.3	-	7	999	c.948C>T	c.(946-948)gaC>gaT	p.D316D	MTHFSD_uc002fjm.3_Silent_p.D315D|MTHFSD_uc010voo.2_Silent_p.D296D|MTHFSD_uc010vop.2_Silent_p.D153D|MTHFSD_uc010voq.2_Silent_p.D315D|MTHFSD_uc010vor.2_Silent_p.D316D|MTHFSD_uc002fjo.3_Silent_p.D153D	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	Homo sapiens methenyltetrahydrofolate synthetase domain containing (MTHFSD), transcript variant 1, mRNA.	316	RRM.				folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						TCACACGGGCGTCCCCGGGGA	0.682000													16	91					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140710540	140710540	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr5:140710540G>T	uc003lji.2	+	0	289	c.289G>T	c.(289-291)Gct>Tct	p.A97S	PCDHGC5_uc011dan.2_Missense_Mutation_p.A97S	NM_018912	NP_061735	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 1 (PCDHGA1), transcript variant 1, mRNA.	97	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A97S(2)		breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTCTGCGCTCAGAGCAT	0.473000													6	86					5.4927e-09	6.72856e-09	1	1	0
ACOT13	55856	broad.mit.edu	37	6	24701750	24701750	+	Silent	SNP	A	A	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:24701750A>T	uc003nek.3	+	2	559	c.330A>T	c.(328-330)ggA>ggT	p.G110G	ACOT13_uc010jpv.3_Silent_p.G87G	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	Homo sapiens acyl-CoA thioesterase 13 (ACOT13), transcript variant 1, mRNA.	110					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity			large_intestine(1)	1						TGAAGCAAGGAAAAACACTTG	0.378000													7	163					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24628898	24628898	+	Missense_Mutation	SNP	G	G	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr22:24628898G>C	uc002zzp.4	-	3	906	c.489C>G	c.(487-489)ttC>ttG	p.F163L	GGT5_uc002zzo.4_Missense_Mutation_p.F163L|GGT5_uc002zzr.4_Missense_Mutation_p.F131L|GGT5_uc002zzq.4_Missense_Mutation_p.F131L|GGT5_uc011ajm.2_Missense_Mutation_p.P88A|GGT5_uc011ajn.1_Intron	NM_001099781	NP_001093251	P36269	GGT5_HUMAN	Homo sapiens gamma-glutamyltransferase 5 (GGT5), transcript variant 1, mRNA.	163					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						TGGTGGGCTGGAACAGCTGCG	0.701000													28	131					0	0	1	0	0
FBXO22	26263	broad.mit.edu	37	15	76225142	76225142	+	Missense_Mutation	SNP	C	C	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr15:76225142C>A	uc002bbk.3	+	6	1016	c.911C>A	c.(910-912)gCt>gAt	p.A304D	FBXO22_uc002bbl.3_Missense_Mutation_p.A200D|FBXO22-AS1_uc002bbm.1_Non-coding_Transcript	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA.	304					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						ACTGCTGAGGCTGCGATGCAG	0.537000													5	85					8.12818e-05	8.75343e-05	1	1	0
ZNF814	730051	broad.mit.edu	37	19	58385748	58385748	+	Missense_Mutation	SNP	G	G	A	rs145250945		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:58385748G>A	uc002qqo.2	-	2	1282	c.1010C>T	c.(1009-1011)gCt>gTt	p.A337V	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	337					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.A337V(4)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ACTGAAGCTAGCATATTTGCT	0.353000													50	85					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143956	55143956	+	Missense_Mutation	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:55143956A>G	uc002qgj.3	+	6	1043	c.703A>G	c.(703-705)Atc>Gtc	p.I235V	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.3_Missense_Mutation_p.I235V|LILRB1_uc002qgk.3_Missense_Mutation_p.I235V|LILRB1_uc002qgm.3_Missense_Mutation_p.I235V|LILRB1_uc010erq.3_Missense_Mutation_p.I235V|LILRB1_uc010err.3_Non-coding_Transcript	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, mRNA.	235	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.P234S(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GCCAGGTCCTATCGTGGCCCC	0.537000										HNSCC(37;0.09)			56	135					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526001	7526001	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:7526001C>T	uc010sge.2	-	13	3701	c.3675G>A	c.(3673-3675)acG>acA	p.T1225T	CD163L1_uc001qsy.3_Silent_p.T1215T	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	Homo sapiens CD163 molecule-like 1 (CD163L1), mRNA.	1215	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TGGAGATATGCGTTTTAGGAC	0.527000													33	192					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32841388	32841388	+	Silent	SNP	C	C	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr13:32841388C>A	uc001utx.3	+	54	8524	c.8028C>A	c.(8026-8028)gcC>gcA	p.A2676A	FRY_uc010tdw.2_Non-coding_Transcript|FRY_uc001utz.3_Silent_p.A201A|FRY_uc010tdx.2_Silent_p.A46A	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	Homo sapiens furry homolog (Drosophila) (FRY), mRNA.	2676					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane		p.A2676D(1)		NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGCCCGCAGCCTGTGACGATG	0.552000													3	59					0.115264	0.116452	1	1	0
GOLIM4	27333	broad.mit.edu	37	3	167747034	167747034	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr3:167747034T>C	uc011bpe.1	-	10	1834	c.1490A>G	c.(1489-1491)cAg>cGg	p.Q497R	GOLIM4_uc003ffe.2_Missense_Mutation_p.Q497R|GOLIM4_uc011bpf.1_Missense_Mutation_p.Q469R|GOLIM4_uc011bpg.1_Missense_Mutation_p.Q469R	NM_014498	NP_055313	O00461	GOLI4_HUMAN	Homo sapiens golgi integral membrane protein 4 (GOLIM4), mRNA.	497	Gln-rich.|Glu-rich.				transport	Golgi cisterna membrane|Golgi lumen|cis-Golgi network|endocytic vesicle|endosome membrane|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TTGGATTCCCTGGTCCTCTGC	0.383000													5	63					0	0	1	0	0
OSGIN1	29948	broad.mit.edu	37	16	83994295	83994295	+	Nonsense_Mutation	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:83994295G>A	uc002fha.3	+	4	575	c.575G>A	c.(574-576)tGg>tAg	p.W192*	OSGIN1_uc002fhb.3_Nonsense_Mutation_p.W109*|OSGIN1_uc002fhc.3_Nonsense_Mutation_p.W109*	NM_182981	NP_892026	Q9UJX0	OSGI1_HUMAN	Homo sapiens oxidative stress induced growth inhibitor 1 (OSGIN1), nuclear gene encoding mitochondrial protein, mRNA.	192					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity			autonomic_ganglia(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12						GTCCTCACCTGGAAGCACCGG	0.652000													45	96					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	42984469	42984469	+	Missense_Mutation	SNP	G	G	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr20:42984469G>T	uc002xlv.3	+	0	29	c.25G>T	c.(25-27)Ggg>Tgg	p.G9W	HNF4A_uc010zwo.1_5'UTR|HNF4A_uc002xlt.3_Missense_Mutation_p.G9W|HNF4A_uc002xlu.3_Missense_Mutation_p.G9W	NM_175914	NP_787110	P41235	HNF4A_HUMAN	Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 4, mRNA.	157					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|activating transcription factor binding|protein homodimerization activity|receptor binding|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding	p.G9W(1)		endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGCGCCCCTCGGGGCTCCAGT	0.682000													12	40					1.3612e-06	1.58807e-06	1	1	0
CDR2	1039	broad.mit.edu	37	16	22358803	22358803	+	Missense_Mutation	SNP	A	A	G			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:22358803A>G	uc002dkn.3	-	4	1156	c.848T>C	c.(847-849)tTc>tCc	p.F283S		NM_001802	NP_001793	Q01850	CDR2_HUMAN	Homo sapiens cerebellar degeneration-related protein 2, 62kDa (CDR2), mRNA.	283						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		GGGCTCTTTGAAAGGAACATA	0.532000													13	40					0	0	1	0	0
C21orf56	84221	broad.mit.edu	37	21	47602719	47602719	+	Silent	SNP	G	G	A	rs55819909	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr21:47602719G>A	uc011afu.2	-	1	1074	c.12C>T	c.(10-12)ggC>ggT	p.G4G	C21orf56_uc002zii.3_Intron	NM_001142854	NP_115637	Q9H0A9	CU056_HUMAN	Homo sapiens chromosome 21 open reading frame 56 (C21orf56), transcript variant 1, mRNA.	4							protein binding			kidney(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.241)		TCAGCTCGCCGCCTTCAGCCA	0.662000													4	62					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47856826	47856826	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:47856826T>C	uc010xyn.2	+	1	888	c.539T>C	c.(538-540)gTg>gCg	p.V180A	DHX34_uc010elc.1_Missense_Mutation_p.V180A	NM_014681	NP_055496	Q14147	DHX34_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 34 (DHX34), mRNA.	180	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GAGCACCAGGTGGTGGTAGTG	0.662000													15	31					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6860177	6860177	+	Silent	SNP	G	G	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr4:6860177G>A	uc003gjr.4	+	5	925	c.462G>A	c.(460-462)gaG>gaA	p.E154E	KIAA0232_uc003gjq.4_Silent_p.E154E	NM_014743	NP_055558	Q92628	K0232_HUMAN	Homo sapiens KIAA0232 (KIAA0232), transcript variant 1, mRNA.	154							ATP binding	p.E154*(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AAAAGTTAGAGGGGTCTCCCT	0.328000													68	141					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23728528	23728528	+	Silent	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr20:23728528C>T	uc002wtp.3	-	2	422	c.351G>A	c.(349-351)ttG>ttA	p.L117L		NM_001898	NP_001889	P01037	CYTN_HUMAN	Homo sapiens cystatin SN (CST1), mRNA.	117						extracellular region	cysteine-type endopeptidase inhibitor activity	p.L117L(2)		kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CGAAAGAGCACAACTGTTTCT	0.527000													4	101					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13438880	13438880	+	Missense_Mutation	SNP	T	T	C			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr3:13438880T>C	uc003bxv.1	-	2	496	c.413A>G	c.(412-414)aAg>aGg	p.K138R		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	Homo sapiens nucleoporin 210kDa (NUP210), mRNA.	138					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGCCTGGATCTTCAGCTCCAG	0.602000													21	47					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727578	69727578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr16:69727578C>T	uc002exm.2	+	11	4132	c.3796C>T	c.(3796-3798)Cag>Tag	p.Q1266*	NFAT5_uc002exj.2_Nonsense_Mutation_p.Q1190*|NFAT5_uc002exk.2_Nonsense_Mutation_p.Q1190*|NFAT5_uc002exl.2_Nonsense_Mutation_p.Q1284*|NFAT5_uc002exn.2_Nonsense_Mutation_p.Q1283*|NFAT5_uc002exo.2_Non-coding_Transcript|NFAT5_uc002exi.3_Nonsense_Mutation_p.Q1190*	NM_006599	NP_775322	O94916	NFAT5_HUMAN	Homo sapiens nuclear factor of activated T-cells 5, tonicity-responsive (NFAT5), transcript variant 3, mRNA.	1266	Poly-Gln.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						gcaacaacaacagAGCATTTT	0.468000													19	58					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543048	182543051	+	Frame_Shift_Del	DEL	GGTG	GGTG	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr2:182543048_182543051delGGTG	uc021vto.1	-	0	537_540	c.537_540delCACC	c.(535-540)cccaccfs	p.P179fs	CERKL_uc021vtm.1_Intron|CERKL_uc002uod.2_Intron|NEUROD1_uc002uof.3_Frame_Shift_Del_p.P179fs|NEUROD1_uc021vtn.1_Frame_Shift_Del_p.P179fs	NM_002500	NP_002491	Q13562	NDF1_HUMAN	Homo sapiens neurogenic differentiation 1 (NEUROD1), mRNA.	179					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	E-box binding|chromatin binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CCAGGTTGGTGGTGGGTTGGGATA	0.598													22	58	---	---	---	---					
HIST1H2AL	8332	broad.mit.edu	37	6	27833355	27833357	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:27833355_27833357delAAG	uc003njw.3	+	0	249_251	c.223_225delAAG	c.(223-225)aagdel	p.K76del		NM_003511	NP_066408	P0C0S8	H2A1_HUMAN	Homo sapiens histone cluster 1, H2al (HIST1H2AL), mRNA.	76					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding	p.K76N(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						CCGCGACAACAAGAAGACCCGCA	0.665													47	171	---	---	---	---					
TBP	6908	broad.mit.edu	37	6	170871038	170871040	+	In_Frame_Del	DEL	CAA	CAA	-	rs10592950		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr6:170871038_170871040delCAA	uc003qxu.3	+	2	493_495	c.214_216delCAA	c.(214-216)caadel	p.Q95del	TBP_uc011ehf.2_In_Frame_Del_p.Q75del|TBP_uc003qxt.3_In_Frame_Del_p.Q95del|TBP_uc011ehg.1_In_Frame_Del_p.Q95del	NM_003194	NP_001165556	P20226	TBP_HUMAN	Homo sapiens TATA box binding protein (TBP), transcript variant 1, mRNA.	95	Poly-Gln.		Missing.		cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q72del(3)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		gcagcagcagcaacagcaacagc	0.567													7	57	---	---	---	---					
MLL3	58508	broad.mit.edu	37	7	151859497	151859497	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr7:151859497delT	uc003wla.3	-	42	11384	c.11165delA	c.(11164-11166)aagfs	p.K3722fs	MLL3_uc003wkz.3_Frame_Shift_Del_p.K2783fs|MLL3_uc003wky.3_Frame_Shift_Del_p.K1231fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	3722					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGTCTCAGCCTTTTCCAGTTT	0.468			N		medulloblastoma								23	58	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906600	35906601	+	Frame_Shift_Ins	INS	-	-	A	rs112212538	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr9:35906600_35906601insA	uc003zyr.1	+	0	412_413	c.316_317insA	c.(316-318)cccfs	p.P106fs	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.	106	His-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						ccaccaccacccccaccgccac	0.673													3	5	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906601	35906602	+	Frame_Shift_Ins	INS	-	-	CA	rs112212538	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr9:35906601_35906602insCA	uc003zyr.1	+	0	413_414	c.317_318insCA	c.(316-318)cccfs	p.P106fs	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.	106	His-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccacccccaccgccacc	0.678													3	6	---	---	---	---					
MAML2	84441	broad.mit.edu	37	11	95825392	95825392	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:95825392delC	uc001pfw.1	-	1	3088	c.1803delG	c.(1801-1803)cagfs	p.Q601fs		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	601					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgctgctgctgctgctgct	0.537			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								7	127	---	---	---	---					
MAML2	84441	broad.mit.edu	37	11	95825394	95825395	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr11:95825394_95825395delGC	uc001pfw.1	-	1	3085_3086	c.1800_1801delGC	c.(1798-1803)cagcagfs	p.Q600fs		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	Homo sapiens mastermind-like 2 (Drosophila) (MAML2), mRNA.	600					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				tgctgctgctgctgctgctgct	0.540			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								7	134	---	---	---	---					
METTL7A	25840	broad.mit.edu	37	12	51319010	51319030	+	In_Frame_Del	DEL	GGAGTTTGCGGGCCCCTCCGG	GGAGTTTGCGGGCCCCTCCGG	-	rs142438796		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:51319010_51319030delGGAGTTTGCGGGCCCCTCCGG	uc001rxb.3	+	0	477_497	c.189_209delGGAGTTTGCGGGCCCCTCCGG	c.(187-210)caggagtttgcgggcccctccggg>cag	p.EFAGPSG64del	METTL7A_uc010smv.1_In_Frame_Del_p.EFAGPSG64del	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	Homo sapiens methyltransferase like 7A (METTL7A), mRNA.	64						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity	p.A66V(2)		endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	10						GTAACCTGCAGGAGTTTGCGGGCCCCTCCGGGAAACTCTCC	0.543													12	66	---	---	---	---					
TMCC3	57458	broad.mit.edu	37	12	94975986	94975987	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:94975986_94975987insA	uc001tdj.2	-	1	524_525	c.406_407insT	c.(406-408)tatfs	p.Y136fs	TMCC3_uc001tdi.2_Frame_Shift_Ins_p.Y105fs	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	Homo sapiens transmembrane and coiled-coil domain family 3 (TMCC3), mRNA.	136						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CTTTCGATGATACTGCTCTAAC	0.475													12	61	---	---	---	---					
RFC5	5985	broad.mit.edu	37	12	118462664	118462664	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr12:118462664delA	uc001twq.3	+	5	557	c.430delA	c.(430-432)aaafs	p.K144fs	RFC5_uc010syx.2_Frame_Shift_Del_p.K123fs|RFC5_uc010syz.2_Frame_Shift_Del_p.K59fs|RFC5_uc009zwr.3_Frame_Shift_Del_p.K144fs	NM_007370	NP_001123584	P40937	RFC5_HUMAN	Homo sapiens replication factor C (activator 1) 5, 36.5kDa (RFC5), transcript variant 1, mRNA.	144					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle|cell cycle checkpoint|nucleotide-excision repair, DNA gap filling|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGTAATTGAGAAATTCACAGA	0.428													15	38	---	---	---	---					
LRRC16B	90668	broad.mit.edu	37	14	24528535	24528547	+	Frame_Shift_Del	DEL	CATCAATGCCCTG	CATCAATGCCCTG	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr14:24528535_24528547delCATCAATGCCCTG	uc001wlj.2	+	20	1840_1852	c.1683_1695delCATCAATGCCCTG	c.(1681-1695)ctcatcaatgccctgfs	p.L561fs	LRRC16B_uc001wlk.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	Homo sapiens leucine rich repeat containing 16B (LRRC16B), mRNA.	561								p.N563D(2)		breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CCAGCATCCTCATCAATGCCCTGGGCAGCAACA	0.620													40	116	---	---	---	---					
KRTAP4-5	85289	broad.mit.edu	37	17	39305800	39305814	+	In_Frame_Del	DEL	TGGATTCACAGCAAT	TGGATTCACAGCAAT	-	rs35633784		TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr17:39305800_39305814delTGGATTCACAGCAAT	uc002hwb.3	-	0	241_255	c.206_220delATTGCTGTGAATCCA	c.(205-222)tattgctgtgaatccagc>tgc	p.69_74YCCESS>C		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	Homo sapiens keratin associated protein 4-5 (KRTAP4-5), mRNA.	69	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].					keratin filament				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			cggcagcagctggattcacagcaataggggcggca	0.665													7	76	---	---	---	---					
MRPL45P2	653479	broad.mit.edu	37	17	45567533	45567538	+	Splice_Site	DEL	ACACTT	ACACTT	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr17:45567533_45567538delACACTT	uc002ilp.2	-	3		c.535_splice	c.e3+1		MRPL45P2_uc002ilq.3_Splice_Site					Homo sapiens mitochondrial ribosomal protein L45 pseudogene 2 (MRPL45P2), non-coding RNA.																		GACACCTACGACACTTGTGATGCCAT	0.408													17	248	---	---	---	---					
ZNF225	7768	broad.mit.edu	37	19	44636876	44636878	+	In_Frame_Del	DEL	AAA	AAA	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:44636876_44636878delAAA	uc002oyj.1	+	4	2352_2354	c.2109_2111delAAA	c.(2107-2112)ttaaat>ttt	p.703_704LN>F	ZNF225_uc010ejf.1_In_Frame_Del_p.703_704LN>F	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	Homo sapiens zinc finger protein 225 (ZNF225), mRNA.	703					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				CAttatttttaaatgacacataa	0.355													8	84	---	---	---	---					
ZNF225	7768	broad.mit.edu	37	19	44636880	44636885	+	In_Frame_Del	DEL	GACACA	GACACA	-	rs143348426	by1000genomes	TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chr19:44636880_44636885delGACACA	uc002oyj.1	+	4	2356_2361	c.2113_2118delGACACA	c.(2113-2118)gacacadel	p.DT705del	ZNF225_uc010ejf.1_In_Frame_Del_p.DT705del	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	Homo sapiens zinc finger protein 225 (ZNF225), mRNA.	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				atttttaaatgacacataactgttgt	0.359													8	79	---	---	---	---					
TCEANC	170082	broad.mit.edu	37	X	13680806	13680808	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrX:13680806_13680808delCCT	uc010neg.1	+	3	514_516	c.269_271delCCT	c.(268-273)ccctct>cct	p.S91del	TCEANC_uc010nef.1_In_Frame_Del_p.S61del|TCEANC_uc010nee.2_In_Frame_Del_p.S61del|TCEANC_uc004cvk.2_In_Frame_Del_p.S61del|TCEANC_uc004cvl.3_5'Flank	NM_152634	NP_689847	Q8N8B7	TEANC_HUMAN	Homo sapiens transcription elongation factor A (SII) N-terminal and central domain containing (TCEANC), mRNA.	61					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|large_intestine(5)|lung(2)|pancreas(1)	9						AAAAACTGCCCCTCTGTGGCTTT	0.443													33	25	---	---	---	---					
SH3KBP1	30011	broad.mit.edu	37	X	19560042	19560043	+	Splice_Site	INS	-	-	T			TCGA-B9-A5W8-01A-11D-A28G-10	TCGA-B9-A5W8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	28255a70-00c1-45b8-ad54-33a2def9c843	7d548692-a558-4aaa-b70f-8b2861f275ff	g.chrX:19560042_19560043insT	uc004czm.3	-	16	2208	c.1892_splice	c.e16+1	p.K631_splice	SH3KBP1_uc011mje.2_Splice_Site_p.K370_splice|SH3KBP1_uc011mjf.2_Splice_Site_p.K393_splice|SH3KBP1_uc004czl.3_Splice_Site_p.K594_splice|SH3KBP1_uc010nfm.3_Splice_Site_p.K76_splice	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), transcript variant 1, mRNA.	631					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						CAGGCACTCACTTCTGCTGGTC	0.634													41	40	---	---	---	---					
