Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FLJ36000	284124	broad.mit.edu	37	17	21904069	21904069	+	RNA	SNP	C	C	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr17:21904069C>G	uc002gza.2	+	0		c.8C>G								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		tccgaggctccggcctgacct	0.662000													3	17					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511447	195511447	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr3:195511447G>A	uc021xjp.1	-	1	7160	c.7004C>T	c.(7003-7005)aCg>aTg	p.T2335M	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	94					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T2335M(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGAGGCGTGGTGTCACC	0.597000													4	109					0	0	1	0	0
LOC100653515	100653515	broad.mit.edu	37	17	76888505	76888505	+	Silent	SNP	T	T	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr17:76888505T>G	uc002jwg.2	-	2	263	c.81A>C	c.(79-81)tcA>tcC	p.S27S	TIMP2_uc010wty.2_Intron|TIMP2_uc002jwf.3_Intron|LOC100653515_uc021uei.1_5'UTR	NM_001243540	NP_001230469			Homo sapiens differential display clone 8 (LOC100653515), transcript variant 2, mRNA.																		CCCCCGGGCCTGAGGAGCCAC	0.587000													7	223					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31389169	31389169	+	Missense_Mutation	SNP	G	G	C			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr20:31389169G>C	uc002wyc.3	+	18	2403	c.2082G>C	c.(2080-2082)tgG>tgC	p.W694C	DNMT3B_uc002wyd.3_Missense_Mutation_p.W674C|DNMT3B_uc002wye.3_Missense_Mutation_p.W674C|DNMT3B_uc010ztz.2_Missense_Mutation_p.W632C|DNMT3B_uc010zua.2_Missense_Mutation_p.W598C|DNMT3B_uc010gee.3_Non-coding_Transcript|DNMT3B_uc010gef.3_Non-coding_Transcript|DNMT3B_uc002wyf.3_Missense_Mutation_p.W686C|DNMT3B_uc002wyg.3_Missense_Mutation_p.W393C|DNMT3B_uc010geg.3_5'UTR|DNMT3B_uc010geh.3_Non-coding_Transcript	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	Homo sapiens DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B), transcript variant 1, mRNA.	694					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CGTTCTTCTGGATGTTTGAGA	0.532000													60	150					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37642372	37642372	+	Missense_Mutation	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr21:37642372C>T	uc002yvg.3	+	26	5628	c.5549C>T	c.(5548-5550)aCc>aTc	p.T1850I	DOPEY2_uc011aeb.2_Missense_Mutation_p.T1799I	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	Homo sapiens dopey family member 2 (DOPEY2), mRNA.	1850					Golgi to endosome transport|endoplasmic reticulum organization|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTGGAGCAAACCAGCTGGCTA	0.493000													21	49					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904204	21904204	+	RNA	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr17:21904204G>T	uc002gza.2	+	0		c.143G>T								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ctgccaggacggtgttcgggt	0.677000													4	61					0.0215528	0.0219061	1	1	0
STMN4	81551	broad.mit.edu	37	8	27099960	27099960	+	Silent	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr8:27099960G>A	uc011lak.2	-	2	177	c.63C>T	c.(61-63)tcC>tcT	p.S21S	STMN4_uc003xfj.3_Silent_p.S21S|STMN4_uc011lai.2_Silent_p.S21S|STMN4_uc011laj.2_Silent_p.S12S|STMN4_uc003xfk.3_Silent_p.S21S|STMN4_uc010luo.3_Silent_p.S21S	NM_030795	NP_110422	Q9H169	STMN4_HUMAN	Homo sapiens stathmin-like 4 (STMN4), mRNA.	21					intracellular signal transduction					endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	11		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		CCAGGAAGCAGGAGCAGAACA	0.577000													31	76					0	0	1	0	0
ECHDC2	55268	broad.mit.edu	37	1	53362195	53362195	+	Silent	SNP	T	T	C			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:53362195T>C	uc001cup.4	-	9	1122	c.876A>G	c.(874-876)aaA>aaG	p.K292K	ECHDC2_uc001cun.3_Silent_p.K215K|ECHDC2_uc001cuo.4_Silent_p.K261K|ECHDC2_uc021onl.1_Silent_p.K244K|ECHDC2_uc010onk.2_Silent_p.K246K	NM_001198961	NP_001185890	Q86YB7	ECHD2_HUMAN	Homo sapiens enoyl CoA hydratase domain containing 2 (ECHDC2), transcript variant 1, mRNA.	292					fatty acid metabolic process	mitochondrion	lyase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	12						ATGGGGGTCATTTGCCAACAA	0.488000													12	28					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385748	58385748	+	Missense_Mutation	SNP	G	G	A	rs145250945		TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr19:58385748G>A	uc002qqo.2	-	2	1282	c.1010C>T	c.(1009-1011)gCt>gTt	p.A337V	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	337					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.A337V(4)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ACTGAAGCTAGCATATTTGCT	0.353000													56	89					0	0	1	0	0
OXER1	165140	broad.mit.edu	37	2	42990999	42990999	+	Silent	SNP	C	C	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr2:42990999C>A	uc002rss.3	-	0	403	c.321G>T	c.(319-321)ctG>ctT	p.L107L		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	Homo sapiens oxoeicosanoid (OXE) receptor 1 (OXER1), mRNA.	107					regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						TGTTCCCCACCAGGCCCAGGA	0.647000													31	60					2.81731e-10	3.29573e-10	1	1	0
BC012753	0	broad.mit.edu	37	GL000214.1	32611	32611	+	RNA	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chrGL000214.1:32611G>A	uc011mfm.2	+	1		c.820G>A								Homo sapiens cDNA clone IMAGE:3625232, partial cds.																		GTTTCCAAGAGCAACAGGAAA	0.413000													4	25					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50687165	50687165	+	Missense_Mutation	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr5:50687165G>T	uc003jor.3	+	4	1371	c.823G>T	c.(823-825)Ggt>Tgt	p.G275C		NM_002202	NP_002193	P61371	ISL1_HUMAN	Homo sapiens ISL LIM homeobox 1 (ISL1), mRNA.	275	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GAGACACGACGGTGGCTTACA	0.517000													3	108					0.000602214	0.000666737	1	1	0
ZNF567	163081	broad.mit.edu	37	19	37210687	37210687	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr19:37210687G>A	uc010xtl.2	+	5	1283	c.1061G>A	c.(1060-1062)cGt>cAt	p.R354H	ZNF567_uc002oeo.1_Missense_Mutation_p.R354H|ZNF567_uc010xtk.1_Missense_Mutation_p.R354H|ZNF567_uc002oep.4_Missense_Mutation_p.R323H|ZNF567_uc002oeq.1_Missense_Mutation_p.R323H	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	Homo sapiens zinc finger protein 567 (ZNF567), mRNA.	354					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CACCTCATTCGTCATCAGAGA	0.458000													4	81					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125298795	125298795	+	Missense_Mutation	SNP	A	A	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr3:125298795A>T	uc003eic.3	-	2	1060	c.323T>A	c.(322-324)cTt>cAt	p.L108H		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	Homo sapiens oxysterol binding protein-like 11 (OSBPL11), mRNA.	108	PH.				lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						AGCTCCTGCAAGCTGCAAAGT	0.403000													18	71					0	0	1	0	0
RNF2	6045	broad.mit.edu	37	1	185060812	185060812	+	Silent	SNP	T	T	C			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:185060812T>C	uc001grc.1	+	2	422	c.189T>C	c.(187-189)acT>acC	p.T63T	RNF2_uc001grd.1_Silent_p.T63T	NM_007212	NP_009143	Q99496	RING2_HUMAN	Homo sapiens ring finger protein 2 (RNF2), mRNA.	63	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(3)|endometrium(2)|large_intestine(4)|lung(3)|skin(2)	14		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		ACACCATGACTACAAAGGAGT	0.383000													3	113					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50279802	50279802	+	Missense_Mutation	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr22:50279802C>T	uc003bix.2	+	1	2962	c.2492C>T	c.(2491-2493)aCg>aTg	p.T831M	ZBED4_uc021wrx.1_Missense_Mutation_p.T831M	NM_014838	NP_055653	O75132	ZBED4_HUMAN	Homo sapiens zinc finger, BED-type containing 4 (ZBED4), mRNA.	831						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TTCAGCCATACGGTGAACCTG	0.642000													42	86					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32326205	32326205	+	Missense_Mutation	SNP	C	C	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr10:32326205C>A	uc001iwe.4	-	7	1158	c.688G>T	c.(688-690)Gtt>Ttt	p.V230F		NM_004521	NP_004512	P33176	KINH_HUMAN	Homo sapiens kinesin family member 5B (KIF5B), mRNA.	230	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				GCTAAATCAACCAGATAAAGT	0.338000			T	"""RET, ALK"""	NSCLC								7	51					0.0581538	0.0581538	1	1	0
GAD2	2572	broad.mit.edu	37	10	26506915	26506915	+	Missense_Mutation	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr10:26506915C>T	uc001isp.2	+	2	784	c.281C>T	c.(280-282)gCa>gTa	p.A94V	GAD2_uc009xkr.3_Missense_Mutation_p.A94V|GAD2_uc001isq.2_Missense_Mutation_p.A94V	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	Homo sapiens glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2), transcript variant 2, mRNA.	94					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	Golgi membrane|cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	TTTCTCCATGCAACAGGTAAA	0.721000													39	107					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45194975	45194975	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr20:45194975G>A	uc002xsf.2	-	10	1427	c.1387C>T	c.(1387-1389)Ccc>Tcc	p.P463S	SLC13A3_uc010ghn.2_Missense_Mutation_p.P432S|SLC13A3_uc010zxx.2_Missense_Mutation_p.P365S|SLC13A3_uc010zxw.2_Missense_Mutation_p.P413S|SLC13A3_uc002xsg.2_Missense_Mutation_p.P416S|SLC13A3_uc010gho.2_Missense_Mutation_p.P381S|SLC13A3_uc002xse.2_5'Flank|SLC13A3_uc010ghm.2_Missense_Mutation_p.P50S|SLC13A3_uc010zxv.2_Missense_Mutation_p.P48S	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	Homo sapiens solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (SLC13A3), transcript variant 1, mRNA.	463						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	AGGGCGGGGGGCACATTCTCC	0.607000													3	179					0	0	1	0	0
CYP4F30P	100132708	broad.mit.edu	37	2	131447758	131447758	+	RNA	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr2:131447758C>T	uc002tru.1	+	3		c.1467C>T								Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 30, pseudogene (CYP4F30P), non-coding RNA.																		CACTCCCAAGCGGATTGGAGA	0.448000													3	15					0	0	1	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010785	85010785	+	Silent	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr16:85010785G>A	uc010voi.1	-	7	1130	c.777C>T	c.(775-777)ttC>ttT	p.F259F	ZDHHC7_uc002fiq.2_Silent_p.F222F|ZDHHC7_uc002fir.1_Non-coding_Transcript	NM_001145548	NP_001139020	Q9NXF8	ZDHC7_HUMAN	Homo sapiens zinc finger, DHHC-type containing 7 (ZDHHC7), transcript variant 1, mRNA.	222						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(6)|lung(4)	10						CAAGGCACAGGAAGATCAACA	0.463000													31	134					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174500	150174500	+	Missense_Mutation	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr7:150174500G>T	uc003whj.3	+	4	1960	c.1630G>T	c.(1630-1632)Gct>Tct	p.A544S		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	Homo sapiens GTPase, IMAP family member 8 (GIMAP8), mRNA.	544						Golgi apparatus|endoplasmic reticulum|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GGACAAAACAGCTGTGGCGAA	0.502000													8	163					0.00307968	0.00334983	1	1	0
USH2A	7399	broad.mit.edu	37	1	216262462	216262462	+	Missense_Mutation	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:216262462G>T	uc001hku.1	-	22	5165	c.4778C>A	c.(4777-4779)aCt>aAt	p.T1593N		NM_206933	NP_996816	O75445	USH2A_HUMAN	Homo sapiens Usher syndrome 2A (autosomal recessive, mild) (USH2A), transcript variant 2, mRNA.	1593	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.T1593T(1)|p.V1592A(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTAGTTGTAGTTACTTCCAC	0.333000										HNSCC(13;0.011)			12	29					7.81268e-19	9.49777e-19	1	1	0
MUC2	4583	broad.mit.edu	37	11	1093204	1093204	+	Missense_Mutation	SNP	C	C	A	rs56299570		TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr11:1093204C>A	uc001lsx.1	+	30	5050	c.5023C>A	c.(5023-5025)Cca>Aca	p.P1675T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1710	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding	p.P1675T(1)|p.P1642T(1)		NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	gtccccaaccccaacagccat	0.627000													4	28					0.014758	0.0155084	1	1	0
NPHP3	27031	broad.mit.edu	37	3	132418235	132418235	+	Silent	SNP	A	A	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr3:132418235A>T	uc003epe.2	-	12	2051	c.1947T>A	c.(1945-1947)atT>atA	p.I649I	NPHP3_uc003epd.2_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	Homo sapiens nephronophthisis 3 (adolescent) (NPHP3), mRNA.	649					Wnt receptor signaling pathway|maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCACAGAAACAATTACTCTTA	0.328000													16	27					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88471486	88471486	+	Silent	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr12:88471486G>T	uc001tar.3	-	39	5918	c.5574C>A	c.(5572-5574)acC>acA	p.T1858T	CEP290_uc001taq.3_Silent_p.T918T	NM_025114	NP_079390	O15078	CE290_HUMAN	Homo sapiens centrosomal protein 290kDa (CEP290), mRNA.	1858					G2/M transition of mitotic cell cycle|cilium assembly|eye photoreceptor cell development|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						GTAATCCACTGGTTAGTCTTT	0.269000													3	10					0.00024832	0.000279924	1	1	0
C5orf25	375484	broad.mit.edu	37	5	177099140	177099140	+	Missense_Mutation	SNP	T	T	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr5:177099140T>A	uc011dgc.2	-	0	139	c.11A>T	c.(10-12)tAc>tTc	p.Y4F	C5orf25_uc011dgb.1_Non-coding_Transcript	NM_198567	NP_940969	Q8NDZ2	CE025_HUMAN	Homo sapiens chromosome 5 open reading frame 25 (C5orf25), mRNA.	0												all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GATCACGATGTAATCCTCCAT	0.756000													10	26					0	0	1	0	0
C2orf81	388963	broad.mit.edu	37	2	74642280	74642280	+	Missense_Mutation	SNP	T	T	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr2:74642280T>G	uc010yrq.1	-	3	1252	c.943A>C	c.(943-945)Acc>Ccc	p.T315P	DQ588163_uc002sla.3_5'Flank	NM_001145054	NP_001138526			Homo sapiens chromosome 2 open reading frame 81 (C2orf81), mRNA.											endometrium(3)|kidney(1)	4						GAGGGGCGGGTGGCGCCGCCC	0.716000													7	66					0	0	1	0	0
C9orf156	51531	broad.mit.edu	37	9	100672508	100672508	+	Missense_Mutation	SNP	G	G	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr9:100672508G>T	uc004axv.1	-	3	877	c.800C>A	c.(799-801)gCa>gAa	p.A267E	C9orf156_uc004axw.1_Missense_Mutation_p.A164E|C9orf156_uc010msq.1_Missense_Mutation_p.A164E	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Homo sapiens chromosome 9 open reading frame 156 (C9orf156), mRNA.	267					interspecies interaction between organisms		hydrolase activity	p.A267A(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				TTGTTCTTCTGCCACGCTGGA	0.468000													3	168					0.0215528	0.0219061	1	1	0
FAM65C	140876	broad.mit.edu	37	20	49208955	49208955	+	Missense_Mutation	SNP	C	C	G	rs77093450		TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr20:49208955C>G	uc010zyt.2	-	18	2754	c.2503G>C	c.(2503-2505)Ggc>Cgc	p.G835R	FAM65C_uc002xvm.3_Missense_Mutation_p.G831R	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	Homo sapiens family with sequence similarity 65, member C (FAM65C), mRNA.	831										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTCGGAGTGCCGTCCAGCTGG	0.672000													4	103					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99707631	99707631	+	Silent	SNP	G	G	A	rs148894017		TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr7:99707631G>A	uc003uth.3	-	10	1532	c.1395C>T	c.(1393-1395)gaC>gaT	p.D465D	AP4M1_uc003utd.3_Intron|TAF6_uc003utg.3_Silent_p.D330D|TAF6_uc003utm.3_Silent_p.D408D|TAF6_uc003uti.3_Silent_p.D408D|TAF6_uc003utk.3_Silent_p.D408D|TAF6_uc011kji.2_Silent_p.D445D	NM_139315	NP_647476	P49848	TAF6_HUMAN	Homo sapiens TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa (TAF6), transcript variant 2, mRNA.	408					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|cytoplasm|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCACAGGGCCGTCCAGCACAC	0.587000													28	95					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31576342	31576342	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr14:31576342G>A	uc001wrc.1	-	37	7225	c.6736C>T	c.(6736-6738)Cat>Tat	p.H2246Y	HECTD1_uc001wra.1_Missense_Mutation_p.H372Y|HECTD1_uc001wrb.1_Missense_Mutation_p.H372Y	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	Homo sapiens HECT domain containing 1 (HECTD1), mRNA.	2246	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CCAAGGAAATGAAACAGTTTC	0.383000													28	89					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4104179	4104179	+	Missense_Mutation	SNP	T	T	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr11:4104179T>G	uc021qco.1	+	8	1773	c.1205T>G	c.(1204-1206)cTg>cGg	p.L402R	STIM1_uc001lyv.2_Missense_Mutation_p.L402R|STIM1_uc009yef.2_Missense_Mutation_p.L402R|STIM1_uc009yeg.2_Missense_Mutation_p.L229R	NM_003156	NP_003147	Q13586	STIM1_HUMAN	Homo sapiens stromal interaction molecule 1 (STIM1), mRNA.	402					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		AGCTCTTCCCTGGATGATGTA	0.448000													78	172					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83251082	83251082	+	Missense_Mutation	SNP	A	A	C			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr12:83251082A>C	uc001szt.3	+	1	809	c.377A>C	c.(376-378)cAc>cCc	p.H126P	TMTC2_uc001szr.1_Missense_Mutation_p.H126P|TMTC2_uc001szs.1_Missense_Mutation_p.H126P|TMTC2_uc010suk.2_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	Homo sapiens transmembrane and tetratricopeptide repeat containing 2 (TMTC2), mRNA.	126						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						TTTGCTTCTCACCCCATTCAC	0.522000													7	117					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42162966	42162966	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr20:42162966G>A	uc002xkn.1	+	7	780	c.649G>A	c.(649-651)Gtg>Atg	p.V217M	L3MBTL1_uc010zwh.2_Missense_Mutation_p.V526M|L3MBTL1_uc002xkm.3_Missense_Mutation_p.V458M|L3MBTL1_uc010ggl.3_Missense_Mutation_p.V458M|L3MBTL1_uc002xkl.3_Missense_Mutation_p.V458M|L3MBTL1_uc002xko.3_Missense_Mutation_p.V110M	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	Homo sapiens l(3)mbt-like 1 (Drosophila) (L3MBTL1), transcript variant I, mRNA.	458					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	SAM domain binding|identical protein binding|methylated histone residue binding|nucleosomal histone binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						GCTGGAGGCTGTGGACCGCAG	0.632000													21	61					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31208088	31208088	+	Missense_Mutation	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:31208088G>A	uc001bsc.2	-	6	722	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	Homo sapiens lysosomal protein transmembrane 5 (LAPTM5), mRNA.	211					transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTAGCACCGCCACACGCAC	0.557000													4	72					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47258948	47258948	+	Silent	SNP	G	G	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr20:47258948G>A	uc002xtw.1	-	27	3704	c.3681C>T	c.(3679-3681)aaC>aaT	p.N1227N	PREX1_uc002xtv.1_Silent_p.N524N	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (PREX1), mRNA.	1227					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|enzyme binding|phospholipid binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GTCCTACCTGGTTAAAGAGGT	0.607000													3	111					0	0	1	0	0
GNS	2799	broad.mit.edu	37	12	65152878	65152878	+	Missense_Mutation	SNP	A	A	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr12:65152878A>T	uc010ssq.2	-	0	349	c.179T>A	c.(178-180)gTg>gAg	p.V60E	GNS_uc001ssg.4_Missense_Mutation_p.V60E|GNS_uc010ssr.2_Missense_Mutation_p.V60E	NM_002076	NP_002067	P15586	GNS_HUMAN	Homo sapiens glucosamine (N-acetyl)-6-sulfatase (GNS), mRNA.	60						lysosome	N-acetylglucosamine-6-sulfatase activity|metal ion binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(4)	15	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		GCCGCCGAGCACTTCGTCCTG	0.652000													38	132					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237730023	237730023	+	Missense_Mutation	SNP	C	C	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:237730023C>G	uc001hyl.1	+	27	3491	c.3371C>G	c.(3370-3372)cCg>cGg	p.P1124R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA.	1124	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTTGTCAACCGGATCAGGAG	0.532000													38	113					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90174782	90174782	+	Missense_Mutation	SNP	T	T	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr15:90174782T>G	uc002bof.2	-	14	3132	c.3055A>C	c.(3055-3057)Aag>Cag	p.K1019Q	KIF7_uc010upw.1_Missense_Mutation_p.K505Q	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	Homo sapiens kinesin family member 7 (KIF7), mRNA.	1019					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			AGGCGCTGCTTGAGCAGCGAG	0.677000													16	61					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38822920	38822920	+	Silent	SNP	A	A	C			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr22:38822920A>C	uc003avs.1	-	1	1315	c.1218T>G	c.(1216-1218)ggT>ggG	p.G406G	KCNJ4_uc003avt.1_Silent_p.G406G|KCNJ4_uc021wpp.1_Silent_p.G406G	NM_004981	NP_690607	P48050	IRK4_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4 (KCNJ4), transcript variant 2, mRNA.	406					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	PDZ domain binding|inward rectifier potassium channel activity			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					CCTCCTTGGAACCCGCCTCCA	0.672000													6	129					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117143567	117143567	+	Missense_Mutation	SNP	C	C	A			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr9:117143567C>A	uc004biq.3	-	0	182	c.47G>T	c.(46-48)gGg>gTg	p.G16V	AKNA_uc004bir.3_Missense_Mutation_p.G16V|AKNA_uc004bis.3_Missense_Mutation_p.G16V|AKNA_uc010mve.2_Intron|AKNA_uc004biu.1_5'UTR|AKNA_uc004biv.1_Missense_Mutation_p.G16V|AKNA_uc004biw.1_Missense_Mutation_p.G16V	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	Homo sapiens AT-hook transcription factor (AKNA), mRNA.	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GGGGCCCTTCCCCAGGCCAGG	0.622000													22	50					7.87624e-14	9.39091e-14	1	1	0
FAM100A	124402	broad.mit.edu	37	16	4659850	4659850	+	Silent	SNP	T	T	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr16:4659850T>G	uc002cwx.2	-	2	447	c.318A>C	c.(316-318)tcA>tcC	p.S106S		NM_145253	NP_660296	Q8TB05	F100A_HUMAN	Homo sapiens family with sequence similarity 100, member A (FAM100A), mRNA.	106										endometrium(1)|prostate(1)	2						GTGGCGGGGGTGACGTGGCTG	0.716000													4	21					0	0	1	0	0
WDFY4	57705	broad.mit.edu	37	10	49983779	49983779	+	Missense_Mutation	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr10:49983779C>T	uc001jha.4	+	14	2868	c.2791C>T	c.(2791-2793)Ccc>Tcc	p.P931S		NM_020945	NP_065996	Q6ZS81	WDFY4_HUMAN	Homo sapiens WDFY family member 4 (WDFY4), mRNA.	931						integral to membrane	binding			NS(2)|breast(5)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(3)|pancreas(2)|prostate(5)|skin(6)|stomach(1)	48						TCTTGGAATTCCCTCATCTCT	0.453000													24	52					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr13:115047559C>T	uc001vup.3	+	1	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_uc010tkn.2_Silent_p.L91L|UPF3A_uc001vuq.3_Silent_p.L91L|UPF3A_uc001vur.3_Non-coding_Transcript	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	Homo sapiens UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), transcript variant 1, mRNA.	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	RNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.L91L(16)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													3	42					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr19:58385762C>G	uc002qqo.2	-	2	1268	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(4)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													37	79					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228444409	228444410	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr1:228444409_228444410insG	uc009xez.1	+	14	4411_4412	c.4367_4368insG	c.(4366-4368)gcgfs	p.A1456fs	OBSCN_uc001hsn.3_Frame_Shift_Ins_p.A1456fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	1456	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGCCCAGGCGGGGGCCAGCA	0.619													8	381	---	---	---	---					
PRDM6	93166	broad.mit.edu	37	5	122425971	122425972	+	In_Frame_Ins	INS	-	-	CCTCCGCCT	rs141454062	by1000genomes	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr5:122425971_122425972insCCTCCGCCT	uc003kti.3	+	1	651_652	c.262_263insCCTCCGCCT	c.(262-264)acc>aCCTCCGCCTcc	p.94_95insSAS	PRDM6_uc003ktj.3_Non-coding_Transcript	NM_001136239	NP_001129711	Q9NQX0	PRDM6_HUMAN	Homo sapiens PR domain containing 6 (PRDM6), mRNA.	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	7						Ttcctcttccacctccgcctcc	0.782													7	36	---	---	---	---					
F12	2161	broad.mit.edu	37	5	176833055	176833058	+	Frame_Shift_Del	DEL	AGTG	AGTG	-	rs149368999	byFrequency	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr5:176833055_176833058delAGTG	uc003mgo.4	-	2	169_172	c.120_123delCACT	c.(118-123)ctcactfs	p.L40fs		NM_000505	NP_000496	P00748	FA12_HUMAN	Homo sapiens coagulation factor XII (Hageman factor) (F12), mRNA.	40					Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCGGTGACAGTGAGAACTGCAG	0.588									Hereditary Angioedema				23	49	---	---	---	---					
TMEM184A	202915	broad.mit.edu	37	7	1586653	1586654	+	In_Frame_Ins	INS	-	-	GCC	rs112463195	by1000genomes	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr7:1586653_1586654insGCC	uc003skv.4	-	8	1493_1494	c.1176_1177insGGC	c.(1174-1179)insGGC	p.392_393insG	TMEM184A_uc003skt.4_In_Frame_Ins_p.371_372insG|TMEM184A_uc021zyr.1_In_Frame_Ins_p.197_198insG	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	Homo sapiens transmembrane protein 184A (TMEM184A), mRNA.	392						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTCCCGCCGGAGCCGCCGCTGG	0.708													8	20	---	---	---	---					
POM121	9883	broad.mit.edu	37	7	72413723	72413724	+	In_Frame_Ins	INS	-	-	CTC	rs67569765	byFrequency	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr7:72413723_72413724insCTC	uc003twk.2	+	10	3191_3192	c.3191_3192insCTC	c.(3190-3192)ttc>ttCTCc	p.1064_1065insS	POM121_uc003twj.3_In_Frame_Ins_p.799_800insS|POM121_uc010lam.1_In_Frame_Ins_p.799_800insS	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	Homo sapiens POM121 membrane glycoprotein (POM121), mRNA.	1064	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				ACTGCTGTCTTCTTCGGTGCAG	0.663													7	225	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr7:131241030_131241035delGGCGAC	uc003vqw.4	-	0	342_347	c.84_89delGTCGCC	c.(82-90)ccgtcgccc>ccc	p.28_30PSP>P	PODXL_uc003vqx.4_In_Frame_Del_p.28_30PSP>P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	Homo sapiens podocalyxin-like (PODXL), transcript variant 1, mRNA.	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(4)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													32	78	---	---	---	---					
BC080605	0	broad.mit.edu	37	9	68413567	68413567	+	RNA	DEL	G	G	-			TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr9:68413567delG	uc004aex.3	+	0		c.122delG								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CTCCCCCAGTGGCGCCGGATC	0.602													2	4	---	---	---	---					
EBLN1	340900	broad.mit.edu	37	10	22498484	22498485	+	In_Frame_Ins	INS	-	-	AGA	rs145490621	by1000genomes	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr10:22498484_22498485insAGA	uc021pob.1	-	0	428_429	c.428_429insTCT	c.(427-429)ctg>ctTCTg	p.143_143L>LL		NM_001199938	NP_001186867			Homo sapiens endogenous Bornavirus-like nucleoprotein 1 (EBLN1), mRNA.																		CAATGCCTATCAGATCACAGCA	0.455													4	4	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124824721	124824722	+	In_Frame_Ins	INS	-	-	GCCGCTGCT	rs72177573	by1000genomes	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr12:124824721_124824722insGCCGCTGCT	uc021rga.1	-	36	5655_5656	c.5538_5539insAGCAGCGGC	c.(5536-5541)insAGCAGCGGC	p.1846_1847insSSG	NCOR2_uc021rgb.1_In_Frame_Ins_p.1830_1831insSSG|NCOR2_uc010tbb.2_In_Frame_Ins_p.1839_1840insSSG|NCOR2_uc010tbc.2_In_Frame_Ins_p.1829_1830insSSG|NCOR2_uc021rgc.1_In_Frame_Ins_p.1829_1830insSSG|NCOR2_uc010tba.2_In_Frame_Ins_p.1847_1848insSSG|NCOR2_uc010tax.2_5'UTR	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	Homo sapiens nuclear receptor corepressor 2 (NCOR2), transcript variant 1, mRNA.	1850					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|Notch binding|histone deacetylase binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		cccccacccccgccgctgctgc	0.713													25	60	---	---	---	---					
HSPBP1	23640	broad.mit.edu	37	19	55790886	55790887	+	In_Frame_Ins	INS	-	-	GCCGCCGCC	rs10701478	by1000genomes	TCGA-DW-7963-01B-11D-A28G-10	TCGA-DW-7963-10C-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15b3020f-71db-4d0e-8f6a-edf5552e3064	a522a63d-1b4f-46ea-bcfc-5dbbc855a5bb	g.chr19:55790886_55790887insGCCGCCGCC	uc002qkd.3	-	2	424_425	c.90_91insGGCGGCGGC	c.(88-93)insGGCGGCGGC	p.30_31insGGG	HSPBP1_uc002qjx.3_In_Frame_Ins_p.76_77insGGG|HSPBP1_uc002qkc.3_In_Frame_Ins_p.30_31insGGG|BRSK1_uc002qkf.3_5'Flank	NM_001130106	NP_036399	Q9NZL4	HPBP1_HUMAN	Homo sapiens HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 (HSPBP1), transcript variant 2, mRNA.	30	Gly-rich.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGCCGAGGAGCCGCCGCCGC	0.713													15	43	---	---	---	---					
