Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRIM37	4591	broad.mit.edu	37	17	57134407	57134407	+	Missense_Mutation	SNP	T	T	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr17:57134407T>C	uc002iwy.4	-	12	1472	c.1028A>G	c.(1027-1029)tAt>tGt	p.Y343C	TRIM37_uc002iwz.4_Missense_Mutation_p.Y343C|TRIM37_uc002ixa.4_Missense_Mutation_p.Y221C|TRIM37_uc010woc.2_Missense_Mutation_p.Y309C	NM_001005207	NP_056109	O94972	TRI37_HUMAN	Homo sapiens tripartite motif containing 37 (TRIM37), transcript variant 2, mRNA.	343	MATH.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTCTACACGATATTCATATCT	0.318000									Mulibrey Nanism				14	13					0	0	1	0	0
GAB3	139716	broad.mit.edu	37	X	153908429	153908429	+	Missense_Mutation	SNP	A	A	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chrX:153908429A>G	uc004fmk.1	-	8	1675	c.1627T>C	c.(1627-1629)Tca>Cca	p.S543P	GAB3_uc004fmj.1_Missense_Mutation_p.S542P|GAB3_uc010nve.1_Intron|GAB3_uc004fml.1_Missense_Mutation_p.S162P	NM_001081573	NP_001075042	Q8WWW8	GAB3_HUMAN	Homo sapiens GRB2-associated binding protein 3 (GAB3), transcript variant 1, mRNA.	542										NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGGGCTGGTGATGCTGAATTG	0.488000													45	76					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95568462	95568462	+	Missense_Mutation	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr11:95568462C>T	uc001pfu.3	-	14	2177	c.1924G>A	c.(1924-1926)Gtt>Att	p.V642I	MTMR2_uc001pfv.3_Missense_Mutation_p.V570I|MTMR2_uc001pfs.3_Missense_Mutation_p.V570I|MTMR2_uc001pft.3_Missense_Mutation_p.V570I	NM_016156	NP_958438	Q13614	MTMR2_HUMAN	Homo sapiens myotubularin related protein 2 (MTMR2), transcript variant 1, mRNA.	642						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTTTATACAACAGTTTGGACA	0.438000													46	80					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555531	155555531	+	Missense_Mutation	SNP	T	T	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr2:155555531T>C	uc002tyv.1	+	0	439	c.244T>C	c.(244-246)Tgg>Cgg	p.W82R	KCNJ3_uc010zce.1_Missense_Mutation_p.W82R|KCNJ3_uc021vrh.1_Missense_Mutation_p.W82R	NM_002239	NP_002230	P48549	IRK3_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 3 (KCNJ3), mRNA.	82					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	CAAGTGGCGCTGGAACCTCTT	0.592000													25	357					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27445763	27445763	+	Missense_Mutation	SNP	C	C	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr16:27445763C>G	uc002dor.2	+	3	759	c.211C>G	c.(211-213)Ctt>Gtt	p.L71V	IL21R_uc002doq.2_Missense_Mutation_p.L49V|IL21R_uc002dos.2_Missense_Mutation_p.L49V	NM_181079	NP_851565	Q9HBE5	IL21R_HUMAN	Homo sapiens interleukin 21 receptor (IL21R), transcript variant 3, mRNA.	49					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						CACGCTCACCCTTACCTGGTA	0.612000			T	BCL6	NHL								29	38					0	0	1	0	0
C7orf31	136895	broad.mit.edu	37	7	25182389	25182389	+	Missense_Mutation	SNP	T	T	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr7:25182389T>G	uc003sxn.1	-	7	1290	c.729A>C	c.(727-729)aaA>aaC	p.K243N		NM_138811	NP_620166	Q8N865	CG031_HUMAN	Homo sapiens chromosome 7 open reading frame 31 (C7orf31), mRNA.	243										autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						TTTTAGGAGGTTTTGGGTAGA	0.378000													30	43					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43098028	43098028	+	Missense_Mutation	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr19:43098028G>A	uc002oud.2	-	1	191	c.89C>T	c.(88-90)cCg>cTg	p.P30L	AK311181_uc010eif.1_Intron|AK310497_uc010eig.1_Intron|AK310497_uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8), mRNA.	30					immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				AGTGGTGGGCGGGTTCCAGAA	0.507000													4	84					0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	102226	102226	+	Missense_Mutation	SNP	T	T	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chrGL000209.1:102226T>G	uc021vdb.1	+	2	172	c.161T>G	c.(160-162)aTg>aGg	p.M54R	KIR2DL2_uc002qtt.2_Intron|KIR2DL2_uc002qty.3_Intron|KIR2DL2_uc010yie.2_Intron|KIR2DL2_uc002qul.2_Missense_Mutation_p.M54R	NM_014513	NP_055328	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5), mRNA.	54	Ig-like C2-type 1.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										TCAGATGTCATGTTTGAGCAC	0.522000													3	54					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1219218	1219218	+	Silent	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr5:1219218C>T	uc003jbw.4	+	8	1430	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	Homo sapiens solute carrier family 6 (neutral amino acid transporter), member 19 (SLC6A19), mRNA.	458					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGGAGGTGCTCACAGGTACGT	0.642000													36	60					0	0	1	0	0
KLHDC8B	200942	broad.mit.edu	37	3	49212303	49212303	+	Missense_Mutation	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr3:49212303G>A	uc003cwh.3	+	3	905	c.670G>A	c.(670-672)Gtc>Atc	p.V224I	KLHDC8B_uc003cwi.1_Missense_Mutation_p.V97I	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	Homo sapiens kelch domain containing 8B (KLHDC8B), mRNA.	224						cytoplasm				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|stomach(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGAAGGCAGCGTCTTTAGCCT	0.592000													27	24					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31604103	31604103	+	Missense_Mutation	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr14:31604103C>T	uc001wrc.1	-	21	4042	c.3553G>A	c.(3553-3555)Gat>Aat	p.D1185N	HECTD1_uc001wrd.1_Missense_Mutation_p.D700N	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	Homo sapiens HECT domain containing 1 (HECTD1), mRNA.	1185					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTGCAGTCATCAACATGGGTA	0.388000													4	89					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43802332	43802332	+	Missense_Mutation	SNP	G	G	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr21:43802332G>C	uc002zbb.2	-	8	995	c.794C>G	c.(793-795)cCc>cGc	p.P265R	TMPRSS3_uc002zay.2_Missense_Mutation_p.P23R|TMPRSS3_uc002zaz.2_Missense_Mutation_p.P138R|TMPRSS3_uc002zba.2_Missense_Mutation_p.P138R|TMPRSS3_uc002zbc.2_Missense_Mutation_p.P265R|TMPRSS3_uc002zbd.3_Missense_Mutation_p.P265R	NM_024022	NP_076927	P57727	TMPS3_HUMAN	Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA.	265	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						CCATGACTTGGGGAGGTACAA	0.493000													23	34					0	0	1	0	0
OTX1	5013	broad.mit.edu	37	2	63282730	63282730	+	Missense_Mutation	SNP	T	T	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr2:63282730T>A	uc021vim.1	+	4	620	c.344T>A	c.(343-345)gTg>gAg	p.V115E	OTX1_uc002scd.3_Missense_Mutation_p.V115E|OTX1_uc010ypt.2_Missense_Mutation_p.V49E	NM_001199770	NP_001186699	P32242	OTX1_HUMAN	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.	115						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					TCCTCTCCAGTGCGGGAGAGC	0.647000													64	101					0	0	1	0	0
CRBN	51185	broad.mit.edu	37	3	3209472	3209472	+	Missense_Mutation	SNP	T	T	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr3:3209472T>G	uc003bpq.3	-	4	563	c.533A>C	c.(532-534)cAg>cCg	p.Q178P	CRBN_uc003bpr.3_Missense_Mutation_p.Q177P|CRBN_uc011aso.2_Missense_Mutation_p.Q115P	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.	178	Lon.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	11				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		TTTAGCTTGCTGGATTCTAAA	0.333000													15	25					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3765545	3765545	+	Missense_Mutation	SNP	G	G	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr12:3765545G>T	uc010sen.1	-	8	1362	c.790C>A	c.(790-792)Caa>Aaa	p.Q264K	EFCAB4B_uc001qmj.2_Missense_Mutation_p.Q264K|EFCAB4B_uc001qmi.1_Non-coding_Transcript	NM_001144958	NP_001138430	Q9BSW2	EFC4B_HUMAN	Homo sapiens EF-hand calcium binding domain 4B (EFCAB4B), transcript variant 1, mRNA.	264					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCCAGCTCTTGACTGCGGGCT	0.517000													28	51					4.34311e-12	4.67719e-12	1	1	0
SLC11A1	6556	broad.mit.edu	37	2	219249037	219249037	+	Missense_Mutation	SNP	C	C	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr2:219249037C>A	uc002vhv.3	+	2	562	c.222C>A	c.(220-222)gaC>gaA	p.D74E	SLC11A1_uc010zkb.1_Missense_Mutation_p.D74E|SLC11A1_uc010fvp.1_Missense_Mutation_p.D74E|SLC11A1_uc010fvq.1_Missense_Mutation_p.D7E|SLC11A1_uc010zkc.1_Missense_Mutation_p.D7E|SLC11A1_uc002vhu.1_Intron|SLC11A1_uc002vhw.3_5'UTR|SLC11A1_uc010fvr.3_5'Flank	NM_000578	NP_000569	P49279	NRAM1_HUMAN	Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (SLC11A1), mRNA.	74	Pro/Ser-rich.				L-arginine import|MHC class II biosynthetic process|T cell cytokine production|T cell proliferation involved in immune response|activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|mRNA stabilization|macrophage activation|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTTCCTGGACCCAGGAAACA	0.592000													24	51					1.7881e-09	1.87751e-09	1	1	0
CTNNA3	29119	broad.mit.edu	37	10	67726425	67726425	+	Missense_Mutation	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr10:67726425C>T	uc009xpn.1	-	16	2468	c.2345G>A	c.(2344-2346)tGc>tAc	p.C782Y	CTNNA3_uc001jmw.2_Missense_Mutation_p.C782Y	NM_001127384	NP_037398	Q9UI47	CTNA3_HUMAN	Homo sapiens catenin (cadherin-associated protein), alpha 3 (CTNNA3), transcript variant 2, mRNA.	782					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AACTTGACTGCAGATTTTCAG	0.438000													37	56					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44278354	44278354	+	Missense_Mutation	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr19:44278354C>T	uc002oxl.3	-	2	1069	c.673G>A	c.(673-675)Gtg>Atg	p.V225M		NM_002250	NP_002241	O15554	KCNN4_HUMAN	Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4), mRNA.	225					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	CTCTCGGCCACGGACAGCACC	0.677000											OREG0025535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	27					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24125618	24125618	+	Missense_Mutation	SNP	G	G	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr22:24125618G>T	uc002zxx.3	+	7	1376	c.1354G>T	c.(1354-1356)Ggc>Tgc	p.G452C	MMP11_uc002zxy.3_Non-coding_Transcript	NM_005940	NP_005931	P24347	MMP11_HUMAN	Homo sapiens matrix metallopeptidase 11 (stromelysin 3) (MMP11), mRNA.	452	Hemopexin-like 4.				collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CTTCCTGCGCGGCCGCCTCTA	0.622000													16	124					8.81451e-21	9.74235e-21	1	1	0
ZNF536	9745	broad.mit.edu	37	19	30936011	30936011	+	Missense_Mutation	SNP	G	G	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr19:30936011G>C	uc002nsu.1	+	1	1680	c.1542G>C	c.(1540-1542)gaG>gaC	p.E514D	ZNF536_uc010edd.1_Missense_Mutation_p.E514D	NM_014717	NP_055532	O15090	ZN536_HUMAN	Homo sapiens zinc finger protein 536 (ZNF536), mRNA.	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGGCTGCGGAGATGGACCCCG	0.632000													18	21					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3744474	3744474	+	Missense_Mutation	SNP	T	T	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr11:3744474T>A	uc001lyh.3	-	15	2480	c.2059A>T	c.(2059-2061)Agc>Tgc	p.S687C	NUP98_uc001lyi.3_Missense_Mutation_p.S687C|NUP98_uc001lyj.2_Missense_Mutation_p.S687C|NUP98_uc001lyk.2_Missense_Mutation_p.S704C	NM_016320	NP_057404	P52948	NUP98_HUMAN	Homo sapiens nucleoporin 98kDa (NUP98), transcript variant 1, mRNA.	704					DNA replication|carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|mitotic prometaphase|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|cytosol|nuclear membrane|nucleoplasm	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCTTCACTGCTTCCTTCCAGC	0.433000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								82	136					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90048545	90048545	+	Silent	SNP	A	A	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr1:90048545A>G	uc001dni.3	+	6	843	c.336A>G	c.(334-336)aaA>aaG	p.K112K	LRRC8B_uc001dnh.3_Silent_p.K112K|LRRC8B_uc001dnj.3_Silent_p.K112K	NM_001134476	NP_056165	Q6P9F7	LRC8B_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member B (LRRC8B), transcript variant 2, mRNA.	112						integral to membrane		p.E111*(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTTACGAGAAACAGCTCCATT	0.512000													45	88					0	0	1	0	0
ACVR2B	93	broad.mit.edu	37	3	38519723	38519723	+	Silent	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr3:38519723G>A	uc003cif.3	+	3	486	c.462G>A	c.(460-462)ctG>ctA	p.L154L	ACVR2B_uc003cig.3_5'UTR	NM_001106	NP_001097	Q13705	AVR2B_HUMAN	Homo sapiens activin A receptor, type IIB (ACVR2B), mRNA.	154					BMP signaling pathway|activin receptor signaling pathway|anterior/posterior pattern formation|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	ATP binding|activin receptor activity|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		TCATCGTCCTGCTGGCCTTTT	0.642000													3	103					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874582	33874582	+	Missense_Mutation	SNP	G	G	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr20:33874582G>C	uc021wck.1	-	3	2118	c.2000C>G	c.(1999-2001)tCt>tGt	p.S667C	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Missense_Mutation_p.S322C	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	Homo sapiens family with sequence similarity 83, member C (FAM83C), mRNA.	667										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTCATCCCCAGACCCAGCTCC	0.617000													81	120					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31660577	31660577	+	Missense_Mutation	SNP	A	A	G			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr20:31660577A>G	uc002wym.1	+	13	1379	c.1379A>G	c.(1378-1380)aAt>aGt	p.N460S		NM_182658	NP_872599	P59826	LPLC3_HUMAN	Homo sapiens BPI fold containing family B, member 3 (BPIFB3), mRNA.	460					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										AATTTTTCCAATTCAGTTCTG	0.473000													47	74					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5396874	5396874	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr7:5396874G>A	uc003soi.4	-	15	5216	c.4867C>T	c.(4867-4869)Cag>Tag	p.Q1623*	TNRC18_uc003soj.3_Nonsense_Mutation_p.Q5*	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	Homo sapiens trinucleotide repeat containing 18 (TNRC18), mRNA.	1623							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AACTGCTCCTGGTCGCTGGCC	0.507000													40	56					0	0	1	0	0
VCX	26609	broad.mit.edu	37	X	7811790	7811790	+	Silent	SNP	C	C	T			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chrX:7811790C>T	uc004crz.3	+	2	573	c.354C>T	c.(352-354)agC>agT	p.S118S		NM_013452	NP_038480	Q9H320	VCX1_HUMAN	Homo sapiens variable charge, X-linked (VCX), mRNA.	118	10 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.|Glu-rich.				chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding	p.S118S(2)		NS(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	10		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				GTCAGGAGAGCGAGGTGGAAG	0.637000													87	124					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30550906	30550906	+	Missense_Mutation	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr6:30550906G>A	uc003nql.3	+	9	951	c.856G>A	c.(856-858)Gtg>Atg	p.V286M	ABCF1_uc003nqk.2_Missense_Mutation_p.V287M|ABCF1_uc003nqm.3_Missense_Mutation_p.V248M|MIR877_uc021yud.1_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	Homo sapiens ATP-binding cassette, sub-family F (GCN20), member 1 (ABCF1), transcript variant 1, mRNA.	286					inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						TGACTTCTCCGTGTCCCAGGC	0.498000													3	95					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27459874	27459874	+	Missense_Mutation	SNP	T	T	C			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr16:27459874T>C	uc002dor.2	+	9	1501	c.953T>C	c.(952-954)tTc>tCc	p.F318S	IL21R_uc002doq.2_Missense_Mutation_p.F296S|IL21R_uc002dos.2_Missense_Mutation_p.F296S|LOC283888_uc002dot.3_Non-coding_Transcript	NM_181079	NP_851565	Q9HBE5	IL21R_HUMAN	Homo sapiens interleukin 21 receptor (IL21R), transcript variant 3, mRNA.	296			S -> R (in dbSNP:rs3093385).		natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						GGTGCACCCTTCACTGGCTCC	0.547000			T	BCL6	NHL								49	75					0	0	1	0	0
C9orf153	389766	broad.mit.edu	37	9	88844472	88844472	+	Missense_Mutation	SNP	G	G	A			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr9:88844472G>A	uc004aoo.3	-	1	128	c.47C>T	c.(46-48)gCc>gTc	p.A16V	GOLM1_uc010mqd.1_Intron|C9orf153_uc004aon.3_Missense_Mutation_p.A16V	NM_001010907	NP_001010907	Q5TBE3	CI153_HUMAN	Homo sapiens chromosome 9 open reading frame 153 (C9orf153), mRNA.	16										breast(1)|lung(1)	2						AGGAAGGGTGGCTTCTCTATT	0.393000													26	44					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96533514	96533514	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr3:96533514delA	uc010how.1	+	0	90	c.47delA	c.(46-48)cagfs	p.Q16fs	EPHA6_uc003drp.1_Frame_Shift_Del_p.Q16fs	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	Homo sapiens EPH receptor A6 (EPHA6), transcript variant 1, mRNA.	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CCGGCGCCGCAGGCAGCGTCC	0.711													3	3	---	---	---	---					
EBLN1	340900	broad.mit.edu	37	10	22498484	22498485	+	In_Frame_Ins	INS	-	-	AGA	rs145490621	by1000genomes	TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr10:22498484_22498485insAGA	uc021pob.1	-	0	428_429	c.428_429insTCT	c.(427-429)ctg>ctTCTg	p.143_143L>LL		NM_001199938	NP_001186867			Homo sapiens endogenous Bornavirus-like nucleoprotein 1 (EBLN1), mRNA.																		CAATGCCTATCAGATCACAGCA	0.455													3	3	---	---	---	---					
MYPOP	339344	broad.mit.edu	37	19	46393972	46393972	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IA-A40X-01A-11D-A25F-10	TCGA-IA-A40X-10A-01D-A25F-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e1217ebe-1826-41a9-b6c4-702100a66f5e	611a2445-8df1-4abd-bb6b-4954ee1dc47d	g.chr19:46393972delG	uc002pdt.3	-	2	1196	c.1109delC	c.(1108-1110)ccafs	p.P370fs		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Homo sapiens Myb-related transcription factor, partner of profilin (MYPOP), mRNA.	370	Pro-rich.					nucleus	DNA binding	p.A371fs*>30(1)		large_intestine(2)|lung(1)|skin(1)	4						GAGCGGGGCTGGGGGGGGCCG	0.662													2	4	---	---	---	---					
