Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLTCL1	8218	broad.mit.edu	37	22	19213138	19213138	+	Missense_Mutation	SNP	C	C	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr22:19213138C>A	uc021wle.1	-	12	2041	c.1966G>T	c.(1966-1968)Ggc>Tgc	p.G656C	CLTCL1_uc021wld.1_Missense_Mutation_p.G656C|CLTCL1_uc021wlc.1_Missense_Mutation_p.G656C|CLTCL1_uc021wlf.1_Missense_Mutation_p.G656C|CLTCL1_uc011agw.1_Missense_Mutation_p.G656C	NM_007098	NP_009029	P53675	CLH2_HUMAN	Homo sapiens clathrin, heavy chain-like 1 (CLTCL1), transcript variant 1, mRNA.	656	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					GATAAGGAGCCAAAGAAATTG	0.473000			T	?	ALCL								5	40					0.0581538	0.0617246	1	1	0
TSR1	55720	broad.mit.edu	37	17	2237906	2237906	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:2237906G>T	uc002fuj.3	-	4	1798	c.841C>A	c.(841-843)Cag>Aag	p.Q281K	SGSM2_uc002fum.4_5'Flank|SGSM2_uc002fun.4_5'Flank|SGSM2_uc010vqw.2_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	Homo sapiens TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (TSR1), mRNA.	281					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						TTCAGAGTCTGCCCTCGAACA	0.458000													3	121					0.00909568	0.00991511	1	1	0
SUPT6H	6830	broad.mit.edu	37	17	27014486	27014486	+	Silent	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:27014486G>T	uc010crt.3	+	23	3195	c.3003G>T	c.(3001-3003)ctG>ctT	p.L1001L	SUPT6H_uc002hby.3_Silent_p.L1001L|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	Homo sapiens suppressor of Ty 6 homolog (S. cerevisiae) (SUPT6H), mRNA.	1001					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	RNA binding|hydrolase activity, acting on ester bonds|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CCCACCTCCTGAAGGTAGGAT	0.458000													8	32					0.0581538	0.0617246	1	1	0
DACH1	1602	broad.mit.edu	37	13	72440446	72440446	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr13:72440446G>A	uc021rkj.1	-	0	885	c.462C>T	c.(460-462)agC>agT	p.S154S	DACH1_uc021rkk.1_Silent_p.S154S|DACH1_uc021rkl.1_Silent_p.S154S	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	Homo sapiens dachshund homolog 1 (Drosophila) (DACH1), transcript variant 1, mRNA.	152	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		tgctactactgctgctgctgc	0.662000													3	13					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70488224	70488224	+	Missense_Mutation	SNP	C	C	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr8:70488224C>G	uc003xyg.2	+	4	753	c.192C>G	c.(190-192)aaC>aaG	p.N64K	SULF1_uc010lza.1_Missense_Mutation_p.N64K|SULF1_uc003xyd.2_Missense_Mutation_p.N64K|SULF1_uc003xye.2_Missense_Mutation_p.N64K|SULF1_uc003xyf.2_Missense_Mutation_p.N64K	NM_001128206	NP_055985	Q8IWU6	SULF1_HUMAN	Homo sapiens sulfatase 1 (SULF1), transcript variant 2, mRNA.	64					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	Golgi stack|cell surface|endoplasmic reticulum|extracellular space	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAGTCATGAACAAAACGAGAA	0.522000													30	46					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208234136	208234136	+	Missense_Mutation	SNP	A	A	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:208234136A>T	uc001hgz.3	-	12	3391	c.2633T>A	c.(2632-2634)aTc>aAc	p.I878N		NM_025179	NP_079455	O75051	PLXA2_HUMAN	Homo sapiens plexin A2 (PLXNA2), mRNA.	878	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CACGCCATGGATGGTCACTCG	0.582000													28	46					0	0	1	0	0
PEX16	9409	broad.mit.edu	37	11	45936221	45936221	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:45936221G>A	uc001nbt.3	-	5	787	c.475C>T	c.(475-477)Cct>Tct	p.P159S	PEX16_uc001nbu.3_Missense_Mutation_p.P159S	NM_057174	NP_476515	Q9Y5Y5	PEX16_HUMAN	Homo sapiens peroxisomal biogenesis factor 16 (PEX16), transcript variant 2, mRNA.	159					ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding	p.P159T(2)		large_intestine(2)|lung(2)|ovary(2)|skin(1)	7				GBM - Glioblastoma multiforme(35;0.223)		TGGTTGCCAGGGCTGTGGTCA	0.582000													19	28					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088804	94088804	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr14:94088804C>T	uc001ybv.1	+	27	4843	c.4760C>T	c.(4759-4761)aCg>aTg	p.T1587M	UNC79_uc001ybs.1_Missense_Mutation_p.T1565M	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	Homo sapiens unc-79 homolog (C. elegans) (UNC79), mRNA.	1742						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGCCCACTGACGCTGAAGCAA	0.582000													3	74					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	194906	194906	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr5:194906C>T	uc003jal.1	+	1	1011	c.983C>T	c.(982-984)gCc>gTc	p.A328V		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	Homo sapiens leucine rich repeat containing 14B (LRRC14B), mRNA.	328										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						GCAGACTGTGCCCACGCTGCC	0.647000													3	51					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:20414280G>A	uc003zoe.2	-	4	823	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_uc011lne.1_Silent_p.S156S|MLLT3_uc011lnf.1_Silent_p.S185S|MLLT3_uc003zof.3_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mRNA.	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(2)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								4	81					0	0	1	0	0
WDFY4	57705	broad.mit.edu	37	10	49986698	49986698	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr10:49986698C>T	uc001jha.4	+	17	3295	c.3218C>T	c.(3217-3219)tCc>tTc	p.S1073F		NM_020945	NP_065996	Q6ZS81	WDFY4_HUMAN	Homo sapiens WDFY family member 4 (WDFY4), mRNA.	1073						integral to membrane	binding			NS(2)|breast(5)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(3)|pancreas(2)|prostate(5)|skin(6)|stomach(1)	48						CTGACCTTCTCCTGCTGGTTC	0.627000													7	17					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70163023	70163023	+	Missense_Mutation	SNP	A	A	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:70163023A>T	uc002eyf.1	+	5	1562	c.605A>T	c.(604-606)aAt>aTt	p.N202I	CLEC18A_uc002exy.3_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.N102I|PDPR_uc002eyg.1_5'Flank	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.	202					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GCCTCCCAAAATGGTGAGCAG	0.512000													103	285					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145608259	145608259	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:145608259G>T	uc001eog.3	-	3	520	c.477C>A	c.(475-477)aaC>aaA	p.N159K	RNF115_uc001eoj.3_5'Flank|POLR3C_uc001eoh.3_Missense_Mutation_p.N146K|POLR3C_uc009wix.3_Missense_Mutation_p.N146K	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	Homo sapiens polymerase (RNA) III (DNA directed) polypeptide C (62kD) (POLR3C), mRNA.	146					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GCACAAATGTGTTTGATACTT	0.517000													4	73					0.00024832	0.00028081	1	1	0
MEGF11	84465	broad.mit.edu	37	15	66250030	66250030	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr15:66250030C>T	uc002apm.2	-	9	1283	c.1142G>A	c.(1141-1143)tGc>tAc	p.C381Y	MEGF11_uc002apl.2_Missense_Mutation_p.C306Y|MEGF11_uc002apn.1_Missense_Mutation_p.C381Y	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	Homo sapiens multiple EGF-like-domains 11 (MEGF11), mRNA.	381						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						GCCTGGCTGGCAGGTACAAGC	0.587000													3	81					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56876035	56876035	+	Missense_Mutation	SNP	A	A	G	rs148279836		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr4:56876035A>G	uc003hbi.3	+	18	2705	c.2471A>G	c.(2470-2472)cAa>cGa	p.Q824R	CEP135_uc003hbj.3_Missense_Mutation_p.Q530R	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	Homo sapiens centrosomal protein 135kDa (CEP135), mRNA.	824					G2/M transition of mitotic cell cycle|centriole replication|centriole-centriole cohesion	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					AGAAGACTGCAAGATGACCTG	0.388000													37	82					0	0	1	0	0
TCEAL4	79921	broad.mit.edu	37	X	102841929	102841929	+	Missense_Mutation	SNP	A	A	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chrX:102841929A>T	uc022cbt.1	+	0	326	c.326A>T	c.(325-327)gAa>gTa	p.E109V	TCEAL4_uc004ekl.3_Missense_Mutation_p.E109V|TCEAL4_uc004ekm.3_Missense_Mutation_p.E109V|TCEAL4_uc004ekn.3_Missense_Mutation_p.E109V	NM_024863	NP_079139	Q96EI5	TCAL4_HUMAN	Homo sapiens transcription elongation factor A (SII)-like 4 (TCEAL4), transcript variant 1, mRNA.	109	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(1)|kidney(1)|large_intestine(2)|skin(2)	6						CCAGGGAGTGAAACAAGGGCT	0.507000													85	16					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54343069	54343069	+	Silent	SNP	T	T	C	rs151307935		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr4:54343069T>C	uc003hag.4	-	8	1999	c.1743A>G	c.(1741-1743)acA>acG	p.T581T	PDGFRA_uc003haa.3_Intron|LNX1_uc003haf.4_Silent_p.T485T|LNX1_uc003hah.4_Non-coding_Transcript	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	Homo sapiens ligand of numb-protein X 1 (LNX1), transcript variant 1, mRNA.	581	PDZ 3.					cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCGAGGATGATGTTCTTTTCA	0.512000													17	21					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67913803	67913803	+	Silent	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:67913803C>T	uc002eur.3	+	15	2111	c.1872C>T	c.(1870-1872)agC>agT	p.S624S	EDC4_uc010cer.3_Silent_p.S243S|EDC4_uc010vkg.1_Silent_p.S556S|EDC4_uc002eus.3_Silent_p.S354S|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	Homo sapiens enhancer of mRNA decapping 4 (EDC4), mRNA.	624	Ser-rich.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		gcagcagcagcagtagcagca	0.602000													3	36					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9809529	9809529	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:9809529G>A	uc001aqh.3	-	6	1734	c.975C>T	c.(973-975)caC>caT	p.H325H	CLSTN1_uc001aqi.3_Silent_p.H315H|CLSTN1_uc010oag.2_Silent_p.H325H	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	Homo sapiens calsyntenin 1 (CLSTN1), transcript variant 1, mRNA.	325					homophilic cell adhesion	Golgi membrane|cell junction|cell projection|endoplasmic reticulum membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CACAGAGCCGGTGGAGGGACT	0.557000													28	34					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26714818	26714818	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr12:26714818G>T	uc001rhg.3	-	34	5115	c.4698C>A	c.(4696-4698)agC>agA	p.S1566R		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	Homo sapiens inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2), mRNA.	1566					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TATTTGAATGGCTCTTCATGA	0.433000													3	87					1	1	1	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070347	141070347	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:141070347C>T	uc010ncq.3	+	3	1427	c.587C>T	c.(586-588)tCc>tTc	p.S196F						Homo sapiens tubulin, beta pseudogene 5 (TUBBP5), non-coding RNA.																		CCGGGTGTCTCCTCAAGGTGA	0.627000													4	5					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6927003	6927003	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:6927003G>T	uc010clt.1	+	1	75	c.13G>T	c.(13-15)Gcc>Tcc	p.A5S	BCL6B_uc002geg.2_Missense_Mutation_p.A5S	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	Homo sapiens B-cell CLL/lymphoma 6, member B (BCL6B), mRNA.	5						nucleus	zinc ion binding			skin(1)	1						GGGTTCCCCCGCCGCCCCGGA	0.647000													3	57					1	1	1	1	0
PTPN14	5784	broad.mit.edu	37	1	214557537	214557537	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:214557537C>T	uc001hkk.2	-	12	2314	c.1661G>A	c.(1660-1662)aGc>aAc	p.S554N	PTPN14_uc021piy.1_Missense_Mutation_p.S318N|PTPN14_uc010pty.2_Missense_Mutation_p.S455N	NM_005401	NP_005392	Q15678	PTN14_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 14 (PTPN14), mRNA.	554					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GTGGGCCGTGCTGTAGTTATG	0.632000													19	27					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114326898	114326898	+	Missense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr8:114326898A>C	uc003ynu.3	-	1	462	c.303T>G	c.(301-303)aaT>aaG	p.N101K	CSMD3_uc003ynt.3_Missense_Mutation_p.N61K|CSMD3_uc011lhx.2_Missense_Mutation_p.N101K|CSMD3_uc010mcx.1_Missense_Mutation_p.N101K|CSMD3_uc003ynx.4_Missense_Mutation_p.N101K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript variant a, mRNA.	101	CUB 1.					integral to membrane|plasma membrane		p.N101N(2)|p.N61N(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTGTATTCTATTTCGTTCTT	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			46	67					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159188095	159188095	+	Missense_Mutation	SNP	G	G	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr6:159188095G>C	uc003qrt.4	-	12	1827	c.1612C>G	c.(1612-1614)Ctg>Gtg	p.L538V	MIR3918_uc021zho.1_5'Flank|EZR_uc011efr.2_Missense_Mutation_p.L145V|EZR_uc011efs.2_Missense_Mutation_p.L506V|EZR_uc003qru.4_Missense_Mutation_p.L538V	NM_003379	NP_003370	P15311	EZRI_HUMAN	Homo sapiens ezrin (EZR), transcript variant 1, mRNA.	538	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GCCTGGGACAGCTCGCTGCTC	0.562000			T	ROS1	NSCLC								28	56					0	0	1	0	0
SMPD1	6609	broad.mit.edu	37	11	6412728	6412728	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:6412728G>A	uc001mcw.3	+	1	618	c.433G>A	c.(433-435)Gtg>Atg	p.V145M	SMPD1_uc021qcz.1_Missense_Mutation_p.V145M|SMPD1_uc001mcv.2_Non-coding_Transcript|SMPD1_uc009yew.3_Missense_Mutation_p.V144M|SMPD1_uc021qda.1_Non-coding_Transcript|SMPD1_uc009yex.3_Non-coding_Transcript	NM_000543	NP_000534	P17405	ASM_HUMAN	Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1), transcript variant 1, mRNA.	143	Saposin B-type.				cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	GGATGACATGGTGGAGGTGTG	0.582000													18	28					0	0	1	0	0
R3HDM2	22864	broad.mit.edu	37	12	57663626	57663626	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr12:57663626G>T	uc009zpm.1	-	12	1489	c.1454C>A	c.(1453-1455)cCc>cAc	p.P485H	R3HDM2_uc010srn.1_Non-coding_Transcript|R3HDM2_uc001snu.2_Missense_Mutation_p.P180H|R3HDM2_uc001snr.2_Missense_Mutation_p.P212H|R3HDM2_uc001sns.2_Missense_Mutation_p.P485H|R3HDM2_uc001snt.2_Missense_Mutation_p.P499H	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	Homo sapiens R3H domain containing 2 (R3HDM2), mRNA.	485	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						AGTGGGGAGGGGCTGACCCGT	0.572000													4	66					1.23904e-05	1.41438e-05	1	1	0
RPRD2	23248	broad.mit.edu	37	1	150443766	150443766	+	Missense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:150443766A>C	uc009wlr.3	+	10	2543	c.2342A>C	c.(2341-2343)gAg>gCg	p.E781A	RPRD2_uc010pcc.1_Missense_Mutation_p.E755A|RPRD2_uc001eup.4_Missense_Mutation_p.E755A	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Homo sapiens regulation of nuclear pre-mRNA domain containing 2 (RPRD2), mRNA.	781	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TACCCCCGAGAGCTCTCCAAT	0.498000													41	58					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	66023695	66023695	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:66023695C>T	uc003dmn.3	-	0	815	c.289G>A	c.(289-291)Gtc>Atc	p.V97I	MAGI1_uc003dmm.3_Missense_Mutation_p.V97I|MAGI1_uc003dmo.3_Missense_Mutation_p.V97I|MAGI1_uc003dmp.3_Missense_Mutation_p.V97I|MAGI1_uc021xac.1_Missense_Mutation_p.V97I|MAGI1_uc003dmr.3_Missense_Mutation_p.V97I	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 1 (MAGI1), transcript variant 3, mRNA.	97	Guanylate kinase-like.|PDZ 1.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TTGAAGGTGACGGCCTCCTTG	0.652000													4	125					0	0	1	0	0
NCF1C	654817	broad.mit.edu	37	7	74573095	74573095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:74573095G>A	uc003ubv.3	-	9	1079	c.940C>T	c.(940-942)Cag>Tag	p.Q314*						Homo sapiens neutrophil cytosolic factor 1C pseudogene (NCF1C), non-coding RNA.																		GGCCGCGCCTGGCGGCGTCGC	0.716000													13	33					0	0	1	0	0
ACP6	51205	broad.mit.edu	37	1	147142085	147142085	+	Missense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:147142085A>C	uc001epr.2	-	0	550	c.86T>G	c.(85-87)gTg>gGg	p.V29G	ACP6_uc009wjj.1_Missense_Mutation_p.V29G	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	Homo sapiens acid phosphatase 6, lysophosphatidic (ACP6), mRNA.	29					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					GGCCAGGGCCACCCGCCGCTG	0.657000													4	21					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:62968690A>G	uc002jez.3	-	3		c.641T>C			AMZ2P1_uc002jfa.3_Non-coding_Transcript|AMZ2P1_uc002jfb.3_Non-coding_Transcript|AMZ2P1_uc010del.2_Non-coding_Transcript					Homo sapiens archaelysin family metallopeptidase 2 pseudogene 1 (AMZ2P1), non-coding RNA.																		AAAATTCCACAAGTCTCTTGG	0.373000													4	178					0	0	1	0	0
IFFO2	126917	broad.mit.edu	37	1	19282228	19282228	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:19282228G>A	uc001bbd.2	-	0	599	c.599C>T	c.(598-600)cCg>cTg	p.P200L		NM_001136265	NP_001129737	Q5TF58	IFFO2_HUMAN	Homo sapiens intermediate filament family orphan 2 (IFFO2), mRNA.	200										endometrium(1)|kidney(1)	2						GCGGATCTCCGGCGTGATGGT	0.736000													6	16					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66433543	66433543	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:66433543C>T	uc003dmx.3	-	14	2368	c.2354G>A	c.(2353-2355)gGc>gAc	p.G785D	SLC25A26_uc011bft.2_Intron|LRIG1_uc011bfu.2_Missense_Mutation_p.G405D|LRIG1_uc003dmw.3_Missense_Mutation_p.G451D|LRIG1_uc010hnz.3_Missense_Mutation_p.G501D|LRIG1_uc010hoa.3_Missense_Mutation_p.G762D	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), mRNA.	785						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTTCCTGCAGCCTGCTGCGGG	0.607000													3	62					0	0	1	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139781730	139781730	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr5:139781730G>A	uc003lfs.2	+	0	332	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	ANKHD1-EIF4EBP3_uc003lfq.2_Missense_Mutation_p.G60S|ANKHD1-EIF4EBP3_uc003lfr.3_Missense_Mutation_p.G60S|BC030152_uc003lfn.3_5'Flank|ANKHD1-EIF4EBP3_uc003lfo.3_Missense_Mutation_p.G60S|ANKHD1-EIF4EBP3_uc003lfp.3_Missense_Mutation_p.G60S|ANKHD1-EIF4EBP3_uc010jfk.3_Missense_Mutation_p.G60S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	Homo sapiens ANKHD1-EIF4EBP3 readthrough (ANKHD1-EIF4EBP3), mRNA.	60						cytoplasm|nucleus	RNA binding			breast(1)|endometrium(8)|kidney(6)|large_intestine(14)|lung(17)|ovary(6)|prostate(2)|skin(1)|urinary_tract(2)	57			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			cggcagcagcggcggcggcgg	0.756000													3	46					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56885619	56885619	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr4:56885619C>T	uc003hbi.3	+	22	3347	c.3113C>T	c.(3112-3114)gCt>gTt	p.A1038V	CEP135_uc003hbj.3_Missense_Mutation_p.A744V	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	Homo sapiens centrosomal protein 135kDa (CEP135), mRNA.	1038					G2/M transition of mitotic cell cycle|centriole replication|centriole-centriole cohesion	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					TCATTGTTGGCTACAAACAGA	0.363000													47	79					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202701002	202701002	+	Nonsense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:202701002A>C	uc009xag.3	-	24	4199	c.4083T>G	c.(4081-4083)taT>taG	p.Y1361*	KDM5B_uc001gyf.3_Nonsense_Mutation_p.Y1325*|KDM5B_uc001gyg.1_Nonsense_Mutation_p.Y1167*	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	Homo sapiens lysine (K)-specific demethylase 5B (KDM5B), mRNA.	1325					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GGGAGTGCAAATATGAGGTTC	0.408000													17	36					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2632748	2632748	+	Missense_Mutation	SNP	T	T	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr4:2632748T>A	uc010ick.3	+	3	618	c.617T>A	c.(616-618)cTc>cAc	p.L206H	FAM193A_uc003gfd.3_Missense_Mutation_p.L6H|FAM193A_uc011bvm.2_Missense_Mutation_p.L6H|FAM193A_uc011bvn.2_Missense_Mutation_p.L6H|FAM193A_uc010icl.3_Missense_Mutation_p.L6H|FAM193A_uc011bvo.2_Non-coding_Transcript|FAM193A_uc010icm.3_Non-coding_Transcript	NM_003704	NP_003695	P78312	F193A_HUMAN	Homo sapiens family with sequence similarity 193, member A (FAM193A), mRNA.	6										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GTCCGCCTGCTCCGGCAGCTG	0.632000													17	32					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189867767	189867767	+	Silent	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:189867767C>T	uc002uqj.1	+	35	2649	c.2532C>T	c.(2530-2532)ccC>ccT	p.P844P		NM_000090	NP_000081	P02461	CO3A1_HUMAN	Homo sapiens collagen, type III, alpha 1 (COL3A1), mRNA.	844	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTGCAGGACCCCCTGGAGGTT	0.493000													25	47					0	0	1	0	0
PRDM12	59335	broad.mit.edu	37	9	133556745	133556745	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:133556745C>T	uc004bzt.1	+	4	853	c.793C>T	c.(793-795)Cac>Tac	p.H265Y		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	Homo sapiens PR domain containing 12 (PRDM12), mRNA.	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		CATGCGCATCCACACGCTGGA	0.711000													23	31					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208234142	208234142	+	Missense_Mutation	SNP	A	A	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:208234142A>G	uc001hgz.3	-	12	3385	c.2627T>C	c.(2626-2628)gTg>gCg	p.V876A		NM_025179	NP_079455	O75051	PLXA2_HUMAN	Homo sapiens plexin A2 (PLXNA2), mRNA.	876	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane		p.R875*(1)		NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ATGGATGGTCACTCGCGTCCC	0.587000													28	41					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588562	72588562	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:72588562G>T	uc002jla.1	+	2	739	c.377G>T	c.(376-378)tGc>tTc	p.C126F	CD300LD_uc002jkz.2_5'Flank|C17orf77_uc021ucq.1_Missense_Mutation_p.C126F	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	Homo sapiens chromosome 17 open reading frame 77 (C17orf77), mRNA.	126	Cys-rich.					extracellular region				breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						TGCAAGGTGTGCCCAAACTTT	0.458000													17	42					1.99824e-07	2.30273e-07	1	1	0
POTEE	445582	broad.mit.edu	37	2	131976330	131976330	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:131976330G>A	uc002tsn.2	+	0	407	c.355G>A	c.(355-357)Gct>Act	p.A119T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	Homo sapiens POTE ankyrin domain family, member E (POTEE), mRNA.	119							ATP binding										CAAGGTGGGCGCTTGGGGAGA	0.597000													66	117					0	0	1	0	0
TMOD1	7111	broad.mit.edu	37	9	100286582	100286582	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:100286582G>A	uc004axl.2	+	1	248	c.112G>A	c.(112-114)Gac>Aac	p.D38N	TMOD1_uc004axk.2_Missense_Mutation_p.D38N	NM_001166116	NP_003266	P28289	TMOD1_HUMAN	Homo sapiens tropomodulin 1 (TMOD1), transcript variant 2, mRNA.	38					muscle filament sliding	cytosol	actin binding	p.D38N(2)		breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		GGATGAGCTGGACCCTGATGT	0.512000													25	43					0	0	1	0	0
CSDE1	7812	broad.mit.edu	37	1	115277116	115277116	+	Missense_Mutation	SNP	T	T	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:115277116T>A	uc001efi.3	-	7	1189	c.667A>T	c.(667-669)Atg>Ttg	p.M223L	CSDE1_uc001efj.3_Non-coding_Transcript|CSDE1_uc001efk.3_Missense_Mutation_p.M177L|CSDE1_uc001efm.3_Missense_Mutation_p.M192L|CSDE1_uc009wgv.3_Missense_Mutation_p.M177L|CSDE1_uc001efl.3_Missense_Mutation_p.M146L|CSDE1_uc001efn.3_Missense_Mutation_p.M146L	NM_001242891	NP_001229820	O75534	CSDE1_HUMAN	Homo sapiens cold shock domain containing E1, RNA-binding (CSDE1), transcript variant 4, mRNA.	177	CSD 3.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|RNA binding|protein binding			NS(1)|breast(4)|endometrium(11)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	51	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCAACAGCATAATGTTGCGA	0.388000													29	237					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21788203	21788203	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:21788203G>A	uc003svc.3	+	52	8568	c.8537G>A	c.(8536-8538)cGc>cAc	p.R2846H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	Homo sapiens dynein, axonemal, heavy chain 11 (DNAH11), mRNA.	2846	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTCAGGTGTCGCATCAGCCGG	0.493000									Kartagener syndrome				3	51					0	0	1	0	0
SIGMAR1	10280	broad.mit.edu	37	9	34637563	34637563	+	Missense_Mutation	SNP	C	C	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:34637563C>G	uc003zvb.3	-	0	206	c.132G>C	c.(130-132)caG>caC	p.Q44H	SIGMAR1_uc003zva.4_Intron|SIGMAR1_uc003zuz.3_5'UTR|SIGMAR1_uc003zvd.3_Non-coding_Transcript|SIGMAR1_uc003zvc.3_Missense_Mutation_p.Q44H|SIGMAR1_uc011loo.1_Missense_Mutation_p.Q44H	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	Homo sapiens sigma non-opioid intracellular receptor 1 (SIGMAR1), transcript variant 1, mRNA.	44					ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding			large_intestine(1)|lung(1)	2					Dextromethorphan(DB00514)	GCCGCGCCAACTGCGCTATCT	0.701000													7	25					0	0	1	0	0
AGPS	8540	broad.mit.edu	37	2	178301756	178301756	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:178301756G>T	uc002ull.2	+	4	658	c.611G>T	c.(610-612)cGa>cTa	p.R204L	AGPS_uc010zfb.1_Missense_Mutation_p.R114L	NM_003659	NP_003650	O00116	ADAS_HUMAN	Homo sapiens alkylglycerone phosphate synthase (AGPS), mRNA.	204	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity	p.R204Q(2)|p.R204R(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ATGTTTGAGCGAATTCCTGAT	0.303000													3	92					1	1	1	1	0
FBXO34	55030	broad.mit.edu	37	14	55817793	55817793	+	Missense_Mutation	SNP	T	T	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr14:55817793T>A	uc021rtk.1	+	0	685	c.685T>A	c.(685-687)Tgc>Agc	p.C229S	FBXO34_uc001xbv.3_Non-coding_Transcript|FBXO34_uc001xbu.3_Missense_Mutation_p.C229S|FBXO34_uc010aoo.3_Missense_Mutation_p.C229S	NM_152231	NP_689417	Q9NWN3	FBX34_HUMAN	Homo sapiens F-box protein 34 (FBXO34), transcript variant 2, mRNA.	229										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						TTCAAAAAACTGCACAAACTC	0.512000													25	39					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37341119	37341119	+	Splice_Site	SNP	T	T	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:37341119T>A	uc002hrm.2	-	8	857	c.649_splice	c.e8-1	p.T217_splice	CACNB1_uc002hrl.1_Splice_Site|CACNB1_uc002hrn.3_Splice_Site_p.T217_splice|CACNB1_uc002hro.3_Splice_Site_p.T262_splice|CACNB1_uc002hrp.2_Intron	NM_000723	NP_000714	Q02641	CACB1_HUMAN	Homo sapiens calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 1, mRNA.	217				T -> S (in Ref. 3; AAA36167).	axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	ATGCTCTGTCTGGGGGGGGAA	0.627000													43	29					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121345735	121345735	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:121345735C>T	uc003eeg.2	+	3	2318	c.2108C>T	c.(2107-2109)cCa>cTa	p.P703L		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	Homo sapiens F-box protein 40 (FBXO40), mRNA.	703					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		AGAATCAGACCACGAGGAAGA	0.478000													42	7					0	0	1	0	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011400	46011400	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr21:46011400G>A	uc002zfm.3	-	0	987	c.966C>T	c.(964-966)tcC>tcT	p.S322S	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	Homo sapiens keratin associated protein 10-6 (KRTAP10-6), mRNA.	322	29 X 5 AA repeats of C-C-X(3).					keratin filament		p.S322S(10)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						AGGCACCACAGGAGGGGACGG	0.692000													5	116					0	0	1	0	0
LOC642846	642846	broad.mit.edu	37	12	9463867	9463867	+	RNA	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr12:9463867G>A	uc001qvp.2	+	11		c.1093G>A			LOC642846_uc010sgp.1_Non-coding_Transcript					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11-like (LOC642846), non-coding RNA.																		CTGCTGGGCCGTCTGGCTGCC	0.622000													4	27					0	0	1	0	0
PHF23	79142	broad.mit.edu	37	17	7139965	7139965	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:7139965G>T	uc002gfa.3	-	3	508	c.281C>A	c.(280-282)gCa>gAa	p.A94E	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.2_Intron|PHF23_uc010cma.3_5'UTR	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	Homo sapiens PHD finger protein 23 (PHF23), mRNA.	94							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						GGATGACTTTGCTTTCTTAAC	0.587000													3	55					0.115264	0.120232	1	1	0
TMTC4	84899	broad.mit.edu	37	13	101287091	101287091	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr13:101287091T>G	uc001vot.3	-	11	1787	c.1474A>C	c.(1474-1476)Agt>Cgt	p.S492R	TMTC4_uc001vou.3_Missense_Mutation_p.S473R|TMTC4_uc010tja.2_Missense_Mutation_p.S362R|TMTC4_uc001vov.1_Missense_Mutation_p.S218R|TMTC4_uc001vow.1_Missense_Mutation_p.S256R	NM_032813	NP_001073137	Q5T4D3	TMTC4_HUMAN	Homo sapiens transmembrane and tetratricopeptide repeat containing 4 (TMTC4), transcript variant 1, mRNA.	473						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GACAGAGCACTTCTGAAAAGC	0.493000													20	38					0	0	1	0	0
ACOT4	122970	broad.mit.edu	37	14	74060593	74060593	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr14:74060593G>T	uc001xoo.3	+	1	899	c.645G>T	c.(643-645)atG>atT	p.M215I		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	Homo sapiens acyl-CoA thioesterase 4 (ACOT4), mRNA.	215					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(234;0.00331)		TATGCTACATGCTTCAACATC	0.423000													3	56					0.115264	0.120232	1	1	0
SPTBN5	51332	broad.mit.edu	37	15	42143073	42143073	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr15:42143073G>A	uc001zos.3	-	65	11128	c.10795C>T	c.(10795-10797)Cga>Tga	p.R3599*		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 5 (SPTBN5), mRNA.	3634	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCCAGGGCTCGCCACCAGCTC	0.647000													3	40					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358389	10358389	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:10358389G>T	uc002gmn.3	-	20	2415	c.2304C>A	c.(2302-2304)ttC>ttA	p.F768L	AK097500_uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	Homo sapiens myosin, heavy chain 4, skeletal muscle (MYH4), mRNA.	768	Actin-binding (By similarity).|Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	ATP binding|actin binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CAGCTTTGAAGAAAACCTTAT	0.403000													28	79					8.58068e-18	1.0179e-17	1	1	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	G	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:49395482G>C	uc021wxw.1	-	0	310	c.230C>G	c.(229-231)cCg>cGg	p.P77R	GPX1_uc021wxx.1_Missense_Mutation_p.P77R	NM_000581	NP_000572	P07203	GPX1_HUMAN	Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 1, mRNA.	77					UV protection|anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion	cytosol|mitochondrion	SH3 domain binding|endopeptidase inhibitor activity|glutathione peroxidase activity			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.726000													4	82					0	0	1	0	0
C17orf48	56985	broad.mit.edu	37	17	10608594	10608594	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:10608594T>G	uc002gmt.3	+	1	426	c.351T>G	c.(349-351)agT>agG	p.S117R	C17orf48_uc002gmv.3_Non-coding_Transcript|C17orf48_uc002gmu.3_Non-coding_Transcript|C17orf48_uc010vvg.1_Missense_Mutation_p.S117R	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	Homo sapiens chromosome 17 open reading frame 48 (C17orf48), mRNA.	117							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding			breast(3)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						ATAACTTCAGTAGAGAGTATT	0.358000													75	63					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128054	152128054	+	Silent	SNP	T	T	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:152128054T>C	uc001ezs.1	-	2	1586	c.1521A>G	c.(1519-1521)caA>caG	p.Q507Q		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	Homo sapiens repetin (RPTN), mRNA.	507	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.Q507Q(2)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						AGTGGGAACTTTGGCCTTGTC	0.498000													4	100					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10470455	10470455	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr8:10470455G>A	uc003wtc.3	-	3	1382	c.1153C>T	c.(1153-1155)Cgg>Tgg	p.R385W		NM_178857	NP_849188	A6NKC6	A6NKC6_HUMAN	Homo sapiens retinitis pigmentosa 1-like 1 (RP1L1), mRNA.	385					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGCAGGGCCGGGGTCCCCAC	0.657000													3	35					0	0	1	0	0
RRP7A	27341	broad.mit.edu	37	22	42910736	42910736	+	Silent	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr22:42910736C>T	uc003bcp.3	-	2	1073	c.579G>A	c.(577-579)agG>agA	p.R193R	RRP7A_uc003bcq.3_Silent_p.R170R	NM_015703	NP_056518	Q9Y3A4	RRP7A_HUMAN	Homo sapiens ribosomal RNA processing 7 homolog A (S. cerevisiae) (RRP7A), mRNA.	170							RNA binding|nucleotide binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	10						CCACTTCCACCCTCAGGGCCT	0.637000													8	94					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159606614	159606614	+	Silent	SNP	A	A	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:159606614A>T	uc003fcq.2	+	8	1609	c.1428A>T	c.(1426-1428)ccA>ccT	p.P476P	IQCJ-SCHIP1_uc003fcr.2_Silent_p.P449P|IQCJ-SCHIP1_uc003fcs.2_Silent_p.P400P|IQCJ-SCHIP1_uc003fct.2_Silent_p.P387P|IQCJ-SCHIP1_uc021xgm.1_Silent_p.P168P|IQCJ-SCHIP1_uc010hvz.1_Silent_p.P360P|IQCJ-SCHIP1_uc003fcu.2_Silent_p.P157P	NM_001197113	NP_001184042	Q9P0W5	SCHI1_HUMAN	Homo sapiens IQCJ-SCHIP1 readthrough (IQCJ-SCHIP1), transcript variant 1, mRNA.	400						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						TTCAGCTGCCACACATGCCTC	0.433000													56	16					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	707223	707223	+	Splice_Site	SNP	T	T	G	rs78538490		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:707223T>G	uc002cii.1	+	20	2527	c.2473_splice	c.e20+2	p.A825_splice	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Splice_Site_p.A352_splice|WDR90_uc002cil.1_Splice_Site|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	Homo sapiens WD repeat domain 90 (WDR90), mRNA.	825										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GAGTGGCAGGTTGGGCCCCCT	0.692000													4	65					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152382499	152382499	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:152382499G>A	uc021vrb.1	-	120	17060	c.17031C>T	c.(17029-17031)gtC>gtT	p.V5677V	NEB_uc002txr.3_Silent_p.V2143V|NEB_uc002txu.3_Silent_p.V7378V|NEB_uc021vrc.1_Silent_p.V7378V|NEB_uc010fnx.3_Silent_p.V5665V|NEB_uc021vrd.1_Silent_p.V5677V|NEB_uc002txt.4_Silent_p.V182V	NM_004543	NP_004534	P20929	NEBU_HUMAN	Homo sapiens nebulin (NEB), transcript variant 3, mRNA.	5677					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	Z disc|actin cytoskeleton|cytosol	actin binding|structural constituent of muscle	p.V5677V(2)|p.V7378V(1)		NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACTTCCTTGACGTGAACAG	0.483000													19	68					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31345772	31345772	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr22:31345772T>G	uc003aje.1	-	5	1461	c.97A>C	c.(97-99)Act>Cct	p.T33P		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	Homo sapiens MORC family CW-type zinc finger 2 (MORC2), mRNA.	95							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CCAATCTGAGTAGACTCAGGT	0.463000													20	31					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135307641	135307641	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:135307641C>T	uc003vsw.3	+	30	4478	c.4447C>T	c.(4447-4449)Cga>Tga	p.R1483*		NM_015135	NP_055950	Q92621	NU205_HUMAN	Homo sapiens nucleoporin 205kDa (NUP205), mRNA.	1483					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.R1483*(2)		breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AGTGGTCTGTCGAGATGCTTG	0.383000													6	119					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469297	131469297	+	Missense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:131469297G>A	uc004bvw.3	+	4	1039	c.646G>A	c.(646-648)Gct>Act	p.A216T	PKN3_uc010myh.3_Missense_Mutation_p.A216T|PKN3_uc022bom.1_Non-coding_Transcript	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	Homo sapiens protein kinase N3 (PKN3), mRNA.	216					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						CAAGGCACTGGCTGAGGTCAG	0.612000													3	49					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018104	1018104	+	Missense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr4:1018104A>C	uc003gce.3	+	5	885	c.724A>C	c.(724-726)Acc>Ccc	p.T242P	FGFRL1_uc003gcf.3_Missense_Mutation_p.T242P|FGFRL1_uc003gcg.3_Missense_Mutation_p.T242P|FGFRL1_uc010ibo.3_Missense_Mutation_p.T242P	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), transcript variant 3, mRNA.	242					regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CACAGAGCGGACCCGTTCCAA	0.706000													25	15					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70255844	70255844	+	Silent	SNP	A	A	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:70255844A>G	uc003tvw.4	+	18	4377	c.3642A>G	c.(3640-3642)acA>acG	p.T1214T	AUTS2_uc003tvx.4_Silent_p.T1190T|AUTS2_uc011keg.2_Silent_p.T666T	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	Homo sapiens autism susceptibility candidate 2 (AUTS2), transcript variant 1, mRNA.	1214										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CCCCTCCGACAGCAGCGCTGA	0.672000													26	65					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775888	72775888	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr18:72775888C>T	uc002llw.2	+	7	6264	c.6211C>T	c.(6211-6213)Cgg>Tgg	p.R2071W		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	Homo sapiens zinc finger protein 407 (ZNF407), transcript variant 1, mRNA.	2071					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CTCTCAGGAGCGGGCACAGGT	0.662000													3	36					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7684501	7684501	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr19:7684501C>T	uc002mgx.3	-	18	2565	c.2539G>A	c.(2539-2541)Gca>Aca	p.A847T		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	Homo sapiens XPA binding protein 2 (XAB2), mRNA.	847					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						CCAAACACTGCGGCTGGCACG	0.647000								Direct reversal of damage;Nucleotide excision repair (NER)					3	31					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092630	1092630	+	Silent	SNP	T	T	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:1092630T>C	uc001lsx.1	+	29	4476	c.4449T>C	c.(4447-4449)acT>acC	p.T1483T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1483	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding	p.T1482P(1)		NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	caaccaccactcccaGCCCTC	0.632000													6	63					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105795252	105795252	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr10:105795252T>G	uc001kxr.3	-	48	3657	c.3488A>C	c.(3487-3489)gAg>gCg	p.E1163A		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	Homo sapiens collagen, type XVII, alpha 1 (COL17A1), mRNA.	1163	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGAGAGGAGCTCCTCATAGGA	0.627000													13	78					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2410353	2410353	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr19:2410353G>A	uc010xgx.2	+	7	1113	c.1113G>A	c.(1111-1113)gtG>gtA	p.V371V	TMPRSS9_uc002lvv.1_Silent_p.V405V	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	Homo sapiens transmembrane protease, serine 9 (TMPRSS9), mRNA.	371	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGATGGTGTGCGCTGGCT	0.577000													3	51					0	0	1	0	0
GTF2IRD2	84163	broad.mit.edu	37	7	74211898	74211898	+	Missense_Mutation	SNP	G	G	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:74211898G>C	uc003ubd.1	-	15	2137	c.1953C>G	c.(1951-1953)atC>atG	p.I651M	GTF2IRD2_uc010lbt.1_Missense_Mutation_p.I198M	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	Homo sapiens GTF2I repeat domain containing 2 (GTF2IRD2), mRNA.	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	11						ttatacaacagatggacttca	0.532000													61	160					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088707	43088707	+	Missense_Mutation	SNP	T	T	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr10:43088707T>C	uc001jaf.1	-	4	1806	c.1691A>G	c.(1690-1692)cAt>cGt	p.H564R	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.H452R|ZNF33B_uc001jad.3_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	Homo sapiens zinc finger protein 33B (ZNF33B), mRNA.	564						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.H564Y(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GGTTGACTTATGGCTAAAGAA	0.413000													32	28					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111775718	111775718	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:111775718G>T	uc004bdo.1	-	0	47	c.5C>A	c.(4-6)gCc>gAc	p.A2D	CTNNAL1_uc004bdp.1_Missense_Mutation_p.A2D	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	Homo sapiens catenin (cadherin-associated protein), alpha-like 1 (CTNNAL1), mRNA.	2					Rho protein signal transduction|cell adhesion	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		GGGAGAGGCGGCCATGGCCCT	0.746000													5	38					2.7689e-08	3.2215e-08	1	1	0
OR5J2	282775	broad.mit.edu	37	11	55944703	55944703	+	Missense_Mutation	SNP	G	G	A	rs143728764		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:55944703G>A	uc010rjb.2	+	0	610	c.610G>A	c.(610-612)Gga>Aga	p.G204R		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily J, member 2 (OR5J2), mRNA.	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S203Y(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					AACCTTCTCCGGAGTCATTGC	0.468000													6	53					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89345819	89345819	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:89345819G>A	uc002fmx.1	-	8	7592	c.7131C>T	c.(7129-7131)gaC>gaT	p.D2377D	ANKRD11_uc002fmy.1_Silent_p.D2377D|ANKRD11_uc002fnc.1_Silent_p.D2377D|ANKRD11_uc002fna.1_Silent_p.D42D|ANKRD11_uc002fnb.1_Silent_p.D2334D	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	Homo sapiens ankyrin repeat domain 11 (ANKRD11), transcript variant 2, mRNA.	2377						nucleus		p.D2377D(2)		breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTGGGCGTCGTCGTCCTCGG	0.716000													3	14					0	0	1	0	0
FBXO5	26271	broad.mit.edu	37	6	153293427	153293427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr6:153293427G>A	uc003qpg.3	-	3	1181	c.1072C>T	c.(1072-1074)Cga>Tga	p.R358*	FBXO5_uc003qph.3_Nonsense_Mutation_p.R312*	NM_012177	NP_001135994	Q9UKT4	FBX5_HUMAN	Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.	358					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		TCATTGTGTCGACTATAAGTA	0.333000													29	49					0	0	1	0	0
FAIM	55179	broad.mit.edu	37	3	138341182	138341182	+	Missense_Mutation	SNP	G	G	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:138341182G>T	uc003esr.3	+	2	524	c.264G>T	c.(262-264)aaG>aaT	p.K88N	FAIM_uc003eso.1_Missense_Mutation_p.K122N|FAIM_uc003esq.3_Missense_Mutation_p.K110N|FAIM_uc003esp.3_Missense_Mutation_p.K122N|FAIM_uc003ess.3_Missense_Mutation_p.K88N	NM_001033032	NP_060617	Q9NVQ4	FAIM1_HUMAN	Homo sapiens Fas apoptotic inhibitory molecule (FAIM), transcript variant 3, mRNA.	88					apoptosis	cytoplasm				kidney(1)|upper_aerodigestive_tract(1)	2						GTCTCAAGAAGTATATGGAGG	0.378000													3	88					0.00909568	0.00991511	1	1	0
PRKAR2A	5576	broad.mit.edu	37	3	48884918	48884918	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:48884918T>G	uc010hki.1	-	0	353	c.112A>C	c.(112-114)Acc>Ccc	p.T38P	PRKAR2A_uc003cux.1_Missense_Mutation_p.T38P|PRKAR2A_uc003cuy.1_Missense_Mutation_p.T38P|AK127190_uc003cuz.1_5'Flank	NM_004157	NP_004148	P13861	KAP2_HUMAN	Homo sapiens protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A), mRNA.	38	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		CGCAGGCGGGTGAAGTACTCC	0.731000													3	43					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133403162	133403162	+	Missense_Mutation	SNP	C	C	A	rs75678275		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:133403162C>A	uc002ttl.3	+	1	1814	c.1345C>A	c.(1345-1347)Cag>Aag	p.Q449K	LYPD1_uc002ttm.4_3'UTR|LYPD1_uc002ttn.3_3'UTR|LYPD1_uc002tto.3_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	Homo sapiens G protein-coupled receptor 39 (GPR39), mRNA.	449						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAATGGTTTTCAGGAGCATGA	0.532000													27	27					3.73988e-18	4.48045e-18	1	1	0
SCN10A	6336	broad.mit.edu	37	3	38739727	38739727	+	Missense_Mutation	SNP	C	C	T	rs151090729	byFrequency	TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:38739727C>T	uc003ciq.3	-	26	4984	c.4984G>A	c.(4984-4986)Ggc>Agc	p.G1662S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	Homo sapiens sodium channel, voltage-gated, type X, alpha subunit (SCN10A), mRNA.	1662					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCATCCCAGCCGGCCGACGTG	0.612000													4	85					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38825504	38825504	+	Missense_Mutation	SNP	A	A	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr6:38825504A>G	uc021yzh.1	+	41	6053	c.5944A>G	c.(5944-5946)Att>Gtt	p.I1982V	DNAH8_uc003ooe.2_Missense_Mutation_p.I1765V	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCAGAGAGATATTTTTGATGA	0.308000													49	47					0	0	1	0	0
MARCH2	51257	broad.mit.edu	37	19	8503277	8503277	+	Silent	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr19:8503277C>T	uc002mjv.3	+	5	1029	c.588C>T	c.(586-588)tcC>tcT	p.S196S	MARCH2_uc002mjw.3_Silent_p.S196S|MARCH2_uc002mjx.3_Silent_p.S126S	NM_016496	NP_057580	Q9P0N8	MARH2_HUMAN	Homo sapiens membrane-associated ring finger (C3HC4) 2 (MARCH2), transcript variant 1, mRNA.	196					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|skin(1)|urinary_tract(1)	10						CACAGGTCTCCTTCCGCTACC	0.637000													19	30					0	0	1	0	0
DNAJC5G	285126	broad.mit.edu	37	2	27500675	27500675	+	Missense_Mutation	SNP	T	T	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:27500675T>A	uc002rjl.1	+	3	585	c.167T>A	c.(166-168)cTg>cAg	p.L56Q	SLC30A3_uc010ylh.2_5'Flank|DNAJC5G_uc010yli.1_Intron|DNAJC5G_uc002rjm.1_Missense_Mutation_p.L56Q	NM_173650	NP_775921	Q8N7S2	DNJ5G_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 5 gamma (DNAJC5G), mRNA.	56	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			cervix(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTAGGAAACTGGCCTTGCGG	0.488000													20	53					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30616114	30616114	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:30616114C>T	uc002dyx.3	-	2	1294	c.974G>A	c.(973-975)cGc>cAc	p.R325H	ZNF689_uc010bzy.3_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	Homo sapiens zinc finger protein 689 (ZNF689), mRNA.	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			GGAGGAGAAGCGCCGCTCGCA	0.697000													3	34					0	0	1	0	0
MAGED2	10916	broad.mit.edu	37	X	54841947	54841947	+	Silent	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chrX:54841947C>T	uc004dtk.1	+	11	1747	c.1653C>T	c.(1651-1653)gcC>gcT	p.A551A	MAGED2_uc004dtl.1_Silent_p.A551A|MAGED2_uc004dtm.1_Silent_p.A466A|MAGED2_uc004dtn.1_Silent_p.A551A|MAGED2_uc004dto.1_Silent_p.A525A	NM_177433	NP_957516	Q9UNF1	MAGD2_HUMAN	Homo sapiens melanoma antigen family D, 2 (MAGED2), transcript variant 2, mRNA.	551										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26						gcactggtgccagtaccagta	0.602000													4	38					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37883597	37883597	+	Missense_Mutation	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr17:37883597C>T	uc002hso.3	+	25	3447	c.3209C>T	c.(3208-3210)gCc>gTc	p.A1070V	ERBB2_uc010cwa.3_Missense_Mutation_p.A1055V|ERBB2_uc002hsm.3_Missense_Mutation_p.A1040V|ERBB2_uc002hsp.3_Missense_Mutation_p.A873V|ERBB2_uc010cwb.3_Intron|ERBB2_uc010wek.2_Missense_Mutation_p.A794V	NM_004448	NP_001005862	P04626	ERBB2_HUMAN	Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA.	1070					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of MAP kinase activity|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|ErbB-3 class receptor binding|epidermal growth factor receptor activity|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GAAGAGGAGGCCCCCAGGTCT	0.617000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			19	41					0	0	1	0	0
RRP7B	91695	broad.mit.edu	37	22	42972566	42972566	+	RNA	SNP	C	C	T			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr22:42972566C>T	uc003bcs.3	-	4		c.513G>A			RRP7B_uc003bct.3_Non-coding_Transcript					Homo sapiens ribosomal RNA processing 7 homolog B (S. cerevisiae) (RRP7B), non-coding RNA.																		CCACTTCCACCCTCAGGGCCT	0.637000													42	64					0	0	1	0	0
FBL	2091	broad.mit.edu	37	19	40331279	40331279	+	Silent	SNP	G	G	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr19:40331279G>A	uc002omn.3	-	1	273	c.159C>T	c.(157-159)ggC>ggT	p.G53G	FBL_uc002omm.1_5'Flank|FBL_uc002omo.2_Silent_p.G53G|FBL_uc010egr.3_Silent_p.G53G	NM_001436	NP_001427	P22087	FBRL_HUMAN	Homo sapiens fibrillarin (FBL), mRNA.	53	DMA/Gly-rich.				rRNA processing|tRNA processing	Cajal body|box C/D snoRNP complex	RNA binding|methyltransferase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		ctcctccaccgccgccgccgc	0.657000													3	55					0	0	1	0	0
MTFR1	9650	broad.mit.edu	37	8	66617127	66617127	+	Missense_Mutation	SNP	A	A	C			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr8:66617127A>C	uc011lep.2	+	4	692	c.480A>C	c.(478-480)aaA>aaC	p.K160N	MTFR1_uc003xvm.2_Missense_Mutation_p.K160N|MTFR1_uc003xvn.2_Missense_Mutation_p.K127N	NM_001145839	NP_001139311	Q15390	MTFR1_HUMAN	Homo sapiens mitochondrial fission regulator 1 (MTFR1), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA.	160						mitochondrion|plasma membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|pancreas(1)|urinary_tract(1)	11			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			AGATTGCCAAAATTGTGACCC	0.458000													47	66					0	0	1	0	0
SLC25A5	292	broad.mit.edu	37	X	118603720	118603720	+	Missense_Mutation	SNP	T	T	G			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chrX:118603720T>G	uc004erh.4	+	1	324	c.208T>G	c.(208-210)Ttc>Gtc	p.F70V	SLC25A5-AS1_uc022cdj.1_5'Flank|SLC25A5-AS1_uc004ere.1_5'Flank|SLC25A5-AS1_uc004erg.1_5'Flank	NM_001152	NP_001143	P05141	ADT2_HUMAN	Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (SLC25A5), nuclear gene encoding mitochondrial protein, mRNA.	70					chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	MMXD complex|integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid	adenine transmembrane transporter activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(2)	12					Clodronate(DB00720)	AGTTCTGTCCTTCTGGCGCGG	0.498000													42	9					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885446	180885457	+	In_Frame_Del	DEL	TCCCAGGGTATG	TCCCAGGGTATG	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr1:180885446_180885457delTCCCAGGGTATG	uc001gok.2	+	1	274_285	c.207_218delTCCCAGGGTATG	c.(205-219)cctcccagggtatgg>ccg	p.PRVW70del		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	Homo sapiens KIAA1614 (KIAA1614), mRNA.	70										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCCCCCAGCCTCCCAGGGTATGGGGAGTACAG	0.599													17	35	---	---	---	---					
RFX8	731220	broad.mit.edu	37	2	102018936	102018936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr2:102018936delT	uc010yvx.1	-	10	1327	c.1207delA	c.(1207-1209)atcfs	p.I403fs	RFX8_uc002tbb.1_Frame_Shift_Del_p.I232fs	NM_001145664	NP_001139136	Q6ZV50	RFX8_HUMAN	Homo sapiens regulatory factor X, 8 (RFX8), mRNA.	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|stomach(1)	3						AAGCCCAGGATCCTGAGGACC	0.607													38	52	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr3:184039744_184039746delGAA	uc003fnp.3	+	9	1643_1645	c.1372_1374delGAA	c.(1372-1374)gaadel	p.E465del	EIF4G1_uc003fno.2_In_Frame_Del_p.E406del|EIF4G1_uc010hxw.2_In_Frame_Del_p.E301del|EIF4G1_uc010hxx.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnt.3_In_Frame_Del_p.E176del|EIF4G1_uc010hxy.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnq.3_In_Frame_Del_p.E378del|EIF4G1_uc003fnr.3_In_Frame_Del_p.E301del|EIF4G1_uc003fns.3_In_Frame_Del_p.E425del|EIF4G1_uc003fnv.4_In_Frame_Del_p.E465del|EIF4G1_uc003fnw.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnx.3_In_Frame_Del_p.E269del	NM_198241	NP_937885	Q04637	IF4G1_HUMAN	Homo sapiens eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1), transcript variant 2, mRNA.	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.562													10	106	---	---	---	---					
ZNF273	10793	broad.mit.edu	37	7	64389208	64389214	+	Frame_Shift_Del	DEL	TTACTAA	TTACTAA	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr7:64389208_64389214delTTACTAA	uc003tto.3	+	3	1578_1584	c.1502_1508delTTACTAA	c.(1501-1509)cttactaaafs	p.L501fs	ZNF273_uc003ttl.3_Frame_Shift_Del_p.L436fs|ZNF273_uc003ttn.3_Frame_Shift_Del_p.L436fs	NM_021148	NP_066971	Q14593	ZN273_HUMAN	Homo sapiens zinc finger protein 273 (ZNF273), transcript variant 1, mRNA.	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TCCTCAACTCTTACTAAACATAAGAGA	0.386													9	61	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105393497	105393499	+	In_Frame_Del	DEL	CTT	CTT	-	rs148864394	byFrequency	TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr8:105393497_105393499delCTT	uc003yly.4	-	8	1616_1618	c.1487_1489delAAG	c.(1486-1491)gaagtc>gtc	p.E496del	DPYS_uc010mcf.1_In_Frame_Del_p.E66del	NM_001385	NP_001376	Q14117	DPYS_HUMAN	Homo sapiens dihydropyrimidinase (DPYS), mRNA.	496					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGTGTGGCGACTTCTCCCTTATA	0.483													26	29	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906599	35906601	+	In_Frame_Del	DEL	CCC	CCC	-	rs112212538	by1000genomes	TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr9:35906599_35906601delCCC	uc003zyr.1	+	0	411_413	c.315_317delCCC	c.(313-318)cacccc>cac	p.P106del	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.	106	His-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						accaccaccacccccaccgccac	0.670													5	7	---	---	---	---					
TTC40	54777	broad.mit.edu	37	10	134738376	134738376	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr10:134738376delG	uc021qbc.1	-	10	1181	c.1080delC	c.(1078-1080)atcfs	p.I360fs		NM_001200049	NP_001186978	Q8IYW2	CJ092_HUMAN	Homo sapiens tetratricopeptide repeat domain 40 (TTC40), mRNA.	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GCCTCTGTATGATATCCAGCT	0.687													39	43	---	---	---	---					
HNRNPKP3	399881	broad.mit.edu	37	11	43283605	43283606	+	RNA	INS	-	-	A			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:43283605_43283606insA	uc001mxe.1	-	1		c.1330_1331insT								Homo sapiens heterogeneous nuclear ribonucleoprotein K pseudogene 3 (HNRNPKP3), non-coding RNA.																		GAAGCAAATGTAAAAAAAAAAA	0.386													3	4	---	---	---	---					
KRTAP5-8	57830	broad.mit.edu	37	11	71249125	71249126	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCCGGCTGTGGG	rs113379698		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:71249125_71249126insGGCTGTGGCTCCGGCTGTGGG	uc001oqr.1	+	0	55_56	c.24_25insGGCTGTGGCTCCGGCTGTGGG	c.(22-27)insGGCTGTGGCTCCGGCTGTGGG	p.22_23insGCGSGCG		NM_021046	NP_066384	O75690	KRA58_HUMAN	Homo sapiens keratin associated protein 5-8 (KRTAP5-8), mRNA.	22						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|lung(2)|skin(1)|stomach(1)	6						GCTGCTCTGGAGGCTGTGGCTC	0.649													24	99	---	---	---	---					
C11orf57	55216	broad.mit.edu	37	11	111953315	111953315	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:111953315delC	uc001pmw.4	+	5	624	c.501delC	c.(499-501)cacfs	p.H167fs	C11orf57_uc001pmr.4_Frame_Shift_Del_p.H166fs|C11orf57_uc001pmt.4_Frame_Shift_Del_p.H167fs|C11orf57_uc001pmv.4_Frame_Shift_Del_p.H166fs|C11orf57_uc001pms.4_Frame_Shift_Del_p.H138fs	NM_001082969	NP_060665	Q6ZUT1	CK057_HUMAN	Homo sapiens chromosome 11 open reading frame 57 (C11orf57), transcript variant 2, mRNA.	166	Lys-rich.									autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		AAAGGTCACACAAAAAACAGA	0.413													79	133	---	---	---	---					
VPS11	55823	broad.mit.edu	37	11	118952015	118952015	+	Frame_Shift_Del	DEL	C	C	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr11:118952015delC	uc010ryx.2	+	15	2688	c.2646delC	c.(2644-2646)ttcfs	p.F882fs	VPS11_uc010ryy.2_Frame_Shift_Del_p.F730fs	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	Homo sapiens vacuolar protein sorting 11 homolog (S. cerevisiae) (VPS11), mRNA.	884					protein transport	HOPS complex|endocytic vesicle|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		ATGATCAATTCCAGCATCAGG	0.532													25	31	---	---	---	---					
ARL6IP4	51329	broad.mit.edu	37	12	123465766	123465770	+	Frame_Shift_Del	DEL	AGAGC	AGAGC	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr12:123465766_123465770delAGAGC	uc001ued.3	+	1	504_508	c.449_453delAGAGC	c.(448-453)aagagcfs	p.K150fs	ARL6IP4_uc001uec.3_Frame_Shift_Del_p.K150fs|ARL6IP4_uc001uee.3_Frame_Shift_Del_p.K150fs|ARL6IP4_uc001uef.3_Frame_Shift_Del_p.K150fs|ARL6IP4_uc001ueg.3_Non-coding_Transcript|ARL6IP4_uc009zxt.3_Frame_Shift_Del_p.K27fs|ARL6IP4_uc001uei.3_Frame_Shift_Del_p.K27fs	NM_018694	NP_061164	Q66PJ3	AR6P4_HUMAN	Homo sapiens ADP-ribosylation-like factor 6 interacting protein 4 (ARL6IP4), transcript variant 1, mRNA.	150	Ser-rich.				RNA splicing	nucleus						all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.11e-05)|Epithelial(86;0.000127)|BRCA - Breast invasive adenocarcinoma(302;0.107)		AGAAAGAAGAAGAGCAGGAAAGACA	0.683													31	114	---	---	---	---					
NUFIP1	26747	broad.mit.edu	37	13	45563329	45563329	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr13:45563329delG	uc001uzp.2	-	0	285	c.243delC	c.(241-243)ttcfs	p.F81fs	KIAA1704_uc010tfo.1_5'Flank|KIAA1704_uc001uzq.3_5'Flank|KIAA1704_uc001uzr.1_5'Flank|KIAA1704_uc001uzs.3_5'Flank	NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	Homo sapiens nuclear fragile X mental retardation protein interacting protein 1 (NUFIP1), mRNA.	81	Pro-rich.				RNA processing|box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|RNA binding|identical protein binding|protein binding, bridging|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		TCTGGGCGTCGAAGGGGGGCG	0.657													22	93	---	---	---	---					
LMO7	4008	broad.mit.edu	37	13	76395479	76395497	+	Frame_Shift_Del	DEL	AAAGAAGATTCTACCACTT	AAAGAAGATTCTACCACTT	-	rs149099643		TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr13:76395479_76395497delAAAGAAGATTCTACCACTT	uc021rkq.1	+	13	2709_2727	c.2374_2392delAAAGAAGATTCTACCACTT	c.(2374-2394)aaagaagattctaccacttttfs	p.K792fs	LMO7_uc010thv.2_Frame_Shift_Del_p.K510fs|LMO7_uc001vjt.1_Frame_Shift_Del_p.K458fs|LMO7_uc001vjv.3_Frame_Shift_Del_p.K559fs|LMO7_uc010thw.2_Frame_Shift_Del_p.K409fs|LMO7_uc001vjw.1_Frame_Shift_Del_p.K465fs	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	Homo sapiens LIM domain 7 (LMO7), transcript variant 1, mRNA.	844						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGAAATTCCCAAAGAAGATTCTACCACTTTTGCAAAAAG	0.457													28	78	---	---	---	---					
CNOT1	23019	broad.mit.edu	37	16	58592566	58592570	+	Frame_Shift_Del	DEL	CAAGA	CAAGA	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr16:58592566_58592570delCAAGA	uc002env.3	-	17	2432_2436	c.2139_2143delTCTTG	c.(2137-2145)cctcttgctfs	p.P713fs	CNOT1_uc002enw.3_Non-coding_Transcript|CNOT1_uc002enu.4_Frame_Shift_Del_p.P713fs|CNOT1_uc002enx.3_Frame_Shift_Del_p.P713fs|CNOT1_uc002enz.1_Frame_Shift_Del_p.P142fs	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	Homo sapiens CCR4-NOT transcription complex, subunit 1 (CNOT1), transcript variant 1, mRNA.	713					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GTCATTCCAGCAAGAGGGTCAATCT	0.400													46	51	---	---	---	---					
EPB41L1	2036	broad.mit.edu	37	20	34765954	34765956	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-IZ-A6M9-01A-11D-A31X-10	TCGA-IZ-A6M9-10A-01D-A31X-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0541b2e4-13f8-4845-a6ba-6dfde158bc09	558c1803-c4c2-42cb-82cb-f3e277bf9beb	g.chr20:34765954_34765956delCTT	uc002xfb.3	+	3	594_596	c.423_425delCTT	c.(421-426)accttc>acc	p.F142del	EPB41L1_uc002xeu.3_In_Frame_Del_p.F80del|EPB41L1_uc010zvo.1_In_Frame_Del_p.F142del|EPB41L1_uc002xev.3_In_Frame_Del_p.F142del|EPB41L1_uc002xew.3_Intron|EPB41L1_uc002xex.3_In_Frame_Del_p.F111del|EPB41L1_uc002xey.3_In_Frame_Del_p.F142del|EPB41L1_uc002xez.3_In_Frame_Del_p.F80del	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	Homo sapiens erythrocyte membrane protein band 4.1-like 1 (EPB41L1), transcript variant 1, mRNA.	142	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					TCGGCCTGACCTTCTGTGATGCT	0.576													20	30	---	---	---	---					
