Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COPS2	9318	broad.mit.edu	37	15	49421727	49421727	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr15:49421727G>A	uc001zxh.3	-	10	1175	c.1096C>T	c.(1096-1098)Ctt>Ttt	p.L366F	COPS2_uc001zxf.3_Missense_Mutation_p.L359F|COPS2_uc010ufa.2_Missense_Mutation_p.L295F	NM_001143887	NP_001137359	P61201	CSN2_HUMAN	Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (COPS2), transcript variant 2, mRNA.	359	PCI.				cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		AATTTTATAAGCACTTGTGTT	0.229000													23	34					0	0	1	0	0
UNC80	285175	broad.mit.edu	37	2	210742711	210742711	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:210742711G>A	uc010zjc.1	+	23	3960	c.3880G>A	c.(3880-3882)Ggg>Agg	p.G1294R	UNC80_uc021vvx.1_Missense_Mutation_p.G1289R|UNC80_uc002vdk.2_Missense_Mutation_p.G455R	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	Homo sapiens unc-80 homolog (C. elegans) (UNC80), transcript variant 1, mRNA.	1294						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						GCTGTGCCACGGGGAAAGTGA	0.448000													30	57					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307106	162307106	+	Silent	SNP	T	T	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:162307106T>A	uc003iqh.3	-	15	2773	c.2337A>T	c.(2335-2337)atA>atT	p.I779I	FSTL5_uc003iqi.3_Silent_p.I778I|FSTL5_uc010iqv.3_Silent_p.I769I	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	Homo sapiens follistatin-like 5 (FSTL5), transcript variant 1, mRNA.	779						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TGAGACTCTTTATCATCTTGA	0.458000													52	63					0	0	1	0	0
FER1L5	90342	broad.mit.edu	37	2	97359251	97359251	+	Missense_Mutation	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:97359251A>T	uc010fia.3	+	30	3382	c.3382A>T	c.(3382-3384)Att>Ttt	p.I1128F	FER1L5_uc002sws.4_5'UTR|FER1L5_uc010fib.1_Non-coding_Transcript|FER1L5_uc010yus.2_5'Flank	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	Homo sapiens fer-1-like 5 (C. elegans) (FER1L5), mRNA.	1128	C2 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						AGGGCCCTTCATTCGGGTGGT	0.612000													29	39					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936503	4936503	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:4936503T>C	uc001lzr.1	-	0	391	c.391A>G	c.(391-393)Atc>Gtc	p.I131V		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily G, member 2 (OR51G2), mRNA.	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGTGGCAGATAGCCACAAAG	0.493000													18	26					0	0	1	0	0
PSMC3IP	29893	broad.mit.edu	37	17	40729246	40729246	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:40729246G>C	uc002iai.2	-	2	253	c.210C>G	c.(208-210)atC>atG	p.I70M	PSMC3IP_uc002iaj.3_Missense_Mutation_p.I7M|PSMC3IP_uc010wgp.1_Non-coding_Transcript|PSMC3IP_uc002iak.2_Missense_Mutation_p.I70M|PSMC3IP_uc010wgn.1_5'UTR|PSMC3IP_uc010wgo.1_Non-coding_Transcript	NM_016556	NP_057640	Q9P2W1	HOP2_HUMAN	Homo sapiens PSMC3 interacting protein (PSMC3IP), transcript variant 2, mRNA.	70					DNA recombination|meiosis	nucleus	DNA binding			endometrium(2)|large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(2)	7		all_cancers(22;0.00426)|Breast(137;0.00116)|all_epithelial(22;0.0395)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CCGCAAAATAGATCTTCTGCT	0.532000													50	81					0	0	1	0	0
MAP2K4	6416	broad.mit.edu	37	17	11998978	11998978	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:11998978C>T	uc002gnj.3	+	3	549	c.480C>T	c.(478-480)taC>taT	p.Y160Y	MAP2K4_uc002gnk.3_Silent_p.Y171Y|MAP2K4_uc010vvi.2_Silent_p.Y42Y|MAP2K4_uc010vvj.2_Silent_p.Y32Y	NM_003010	NP_003001	P45985	MP2K4_HUMAN	Homo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4), mRNA.	160	Protein kinase.				JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|cellular response to mechanical stimulus|innate immune response|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.0?(10)|p.?(1)		NS(1)|biliary_tract(2)|breast(22)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(26)|lung(15)|ovary(8)|pancreas(11)|skin(3)|stomach(2)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	100		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		ATTGCCCATACATTGTTCAGT	0.373000			"""D, Mis, N"""		"""pancreatic, breast, colorectal"""								45	113					0	0	1	0	0
ZBTB42	100128927	broad.mit.edu	37	14	105268528	105268528	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr14:105268528G>A	uc021sem.1	+	0	994	c.994G>A	c.(994-996)Gtg>Atg	p.V332M	ZBTB42_uc001ypp.3_Missense_Mutation_p.V332M	NM_001137601	NP_001131073	B2RXF5	ZBT42_HUMAN	Homo sapiens zinc finger and BTB domain containing 42 (ZBTB42), mRNA.	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding										ACCCGACGGCGTGGCACCCAC	0.637000													18	28					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50660660	50660660	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:50660660C>T	uc003tpi.2	-	15	1820	c.1774G>A	c.(1774-1776)Gtg>Atg	p.V592M	GRB10_uc003tph.3_Missense_Mutation_p.V534M|GRB10_uc003tpj.2_Missense_Mutation_p.V546M|GRB10_uc003tpk.2_Missense_Mutation_p.V592M|GRB10_uc010kzb.2_Missense_Mutation_p.V534M|GRB10_uc003tpl.2_Missense_Mutation_p.V586M|GRB10_uc003tpm.2_Missense_Mutation_p.V534M	NM_005311	NP_005302	Q13322	GRB10_HUMAN	Homo sapiens growth factor receptor-bound protein 10 (GRB10), transcript variant 1, mRNA.	592					insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	SH3/SH2 adaptor activity|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CATAAGGCCACTCGGATGCAG	0.512000									Russell-Silver syndrome				62	201					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228469852	228469852	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:228469852G>T	uc009xez.1	+	30	8460	c.8416G>T	c.(8416-8418)Gag>Tag	p.E2806*	OBSCN_uc001hsn.3_Nonsense_Mutation_p.E2806*|OBSCN_uc001hsp.1_Nonsense_Mutation_p.E505*|OBSCN_uc001hsq.1_Nonsense_Mutation_p.E62*	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	2806	Ig-like 27.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGATGCCGGGGAGGTGGTCTT	0.647000													80	90					1.09269e-41	1.1987e-41	1	1	0
OR5A2	219981	broad.mit.edu	37	11	59189793	59189793	+	Missense_Mutation	SNP	C	C	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:59189793C>A	uc010rkt.2	-	0	634	c.634G>T	c.(634-636)Gtg>Ttg	p.V212L		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily A, member 2 (OR5A2), mRNA.	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						ACCACTAGCACAGACACTATT	0.502000													4	125					0.00909568	0.00922114	1	1	0
SLC35B1	10237	broad.mit.edu	37	17	47780367	47780367	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:47780367T>G	uc002iph.1	-	7	856	c.769A>C	c.(769-771)Atc>Ctc	p.I257L	SLC35B1_uc002ipj.1_Missense_Mutation_p.I133L	NM_005827	NP_005818	P78383	S35B1_HUMAN	Homo sapiens solute carrier family 35, member B1 (SLC35B1), mRNA.	257						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(1)	7						GTCATAAAGATGAAGCTCTAG	0.468000													52	104					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109689599	109689599	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr9:109689599A>G	uc004bcz.3	+	2	3695	c.3406A>G	c.(3406-3408)Aga>Gga	p.R1136G	MIR548Q_uc022bli.1_Intron|ZNF462_uc010mto.3_Missense_Mutation_p.R984G|ZNF462_uc004bda.3_Missense_Mutation_p.R984G	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	Homo sapiens zinc finger protein 462 (ZNF462), mRNA.	1136					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CTACCAGAAAAGACACCCAGA	0.537000													2	12					0	0	1	0	0
NACAD	23148	broad.mit.edu	37	7	45123065	45123065	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:45123065G>A	uc003tmt.3	-	1	2714	c.2714C>T	c.(2713-2715)cCt>cTt	p.P905L		NM_001146334	NP_001139806	O15069	NACAD_HUMAN	Homo sapiens NAC alpha domain containing (NACAD), mRNA.	905					protein transport	cytoplasm|nucleus				breast(1)|endometrium(2)|skin(2)	5						CTGGGACACAGGCGTGGCTGC	0.627000													3	74					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7818467	7818467	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:7818467A>G	uc001qtb.3	-	0	36	c.2T>C	c.(1-3)aTg>aCg	p.M1T	APOBEC1_uc001qtc.3_5'UTR	NM_001644	NP_001635	P41238	ABEC1_HUMAN	Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1), mRNA.	1					DNA demethylation|cytidine to uridine editing|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	RNA binding|cytidine deaminase activity|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTCAGAAGTCATGGTGCTCTG	0.498000													42	118					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197408102	197408102	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr3:197408102G>A	uc003fyc.2	-	15	2511	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F	KIAA0226_uc003fyd.3_Silent_p.F731F|KIAA0226_uc003fye.1_Silent_p.F508F	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	Homo sapiens KIAA0226 (KIAA0226), transcript variant 2, mRNA.	776					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GGTCCTTGGAGAAGTTGCTGA	0.522000													59	69					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101588897	101588897	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:101588897C>T	uc001thz.4	-	3	903	c.513G>A	c.(511-513)gtG>gtA	p.V171V		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	Homo sapiens solute carrier family 5 (iodide transporter), member 8 (SLC5A8), mRNA.	171					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATGTGCAGACCACCCCCGTTG	0.403000													43	34					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517180	158517180	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:158517180C>T	uc010pil.2	-	0	716	c.716G>A	c.(715-717)cGc>cAc	p.R239H		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily Y, member 1 (OR6Y1), mRNA.	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGCCTTTTGGCGGCCCTGAGC	0.522000													75	79					0	0	1	0	0
BTC	685	broad.mit.edu	37	4	75695357	75695357	+	Missense_Mutation	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:75695357A>C	uc003hig.2	-	1	421	c.74T>G	c.(73-75)aTc>aGc	p.I25S		NM_001729	NP_001720	P35070	BTC_HUMAN	Homo sapiens betacellulin (BTC), mRNA.	25					positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(101;0.219)			ACAGTGAAGGATCACTAGACC	0.403000													40	71					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183669307	183669307	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr3:183669307G>C	uc003fmg.3	-	19	3031	c.2866C>G	c.(2866-2868)Ctt>Gtt	p.L956V	ABCC5_uc011bqt.2_Missense_Mutation_p.L484V|ABCC5_uc010hxl.3_Missense_Mutation_p.L956V	NM_005688	NP_005679	O15440	MRP5_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5), transcript variant 1, mRNA.	956	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGGCTTCGAAGGATCCTTCGG	0.542000													31	22					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58579372	58579372	+	Missense_Mutation	SNP	C	C	T	rs2228277		TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr19:58579372C>T	uc002qrg.3	+	3	1595	c.1592C>T	c.(1591-1593)tCg>tTg	p.S531L	ZNF135_uc002qre.3_Missense_Mutation_p.S507L|ZNF135_uc002qrf.3_Missense_Mutation_p.S465L|ZNF135_uc010yhq.2_Missense_Mutation_p.S519L|ZNF135_uc010yhr.2_Missense_Mutation_p.S328L|ZNF135_uc002qrd.2_Intron|ZNF135_uc021vcu.1_3'UTR	NM_007134	NP_009065	B4DHH9	B4DHH9_HUMAN	Homo sapiens zinc finger protein 135 (ZNF135), transcript variant 1, mRNA.	519					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AGTCACAGCTCGTCCCTCACC	0.567000													41	72					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1719998	1719998	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chrX:1719998C>T	uc004cqa.3	+	4	1795	c.1599C>T	c.(1597-1599)ccC>ccT	p.P533P	AKAP17A_uc004cqb.3_Non-coding_Transcript|ASMT_uc004cqd.3_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 17A (AKAP17A), transcript variant 1, mRNA.	533					B cell activation|RNA splicing|mRNA processing|regulation of transcription, DNA-dependent|signal transduction	nuclear speck|spliceosomal complex	RNA binding|nucleotide binding|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						GTGTGGTCCCCGAGGATGGCT	0.657000													4	65					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116100456	116100456	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr10:116100456G>A	uc001lbn.3	-	1	352	c.51C>T	c.(49-51)ttC>ttT	p.F17F	AFAP1L2_uc001lbo.3_Silent_p.F17F|AFAP1L2_uc010qse.2_Silent_p.F17F|AFAP1L2_uc001lbp.3_Silent_p.F17F|AFAP1L2_uc001lbr.1_Silent_p.F17F	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	Homo sapiens actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 1, mRNA.	17					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	SH2 domain binding|SH3 domain binding|protein tyrosine kinase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GAATCTTGAGGAAGTCATCCA	0.537000													28	45					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138718252	138718252	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr5:138718252G>A	uc003leg.3	-	1	176	c.79C>T	c.(79-81)Cct>Tct	p.P27S	SLC23A1_uc003leh.3_Missense_Mutation_p.P27S	NM_152685	NP_689898	Q9UHI7	S23A1_HUMAN	Homo sapiens solute carrier family 23 (nucleobase transporters), member 1 (SLC23A1), transcript variant 2, mRNA.	27					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	L-ascorbate:sodium symporter activity|dehydroascorbic acid transporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	TCAAACTTAGGCTCTGTGGGT	0.582000													59	76					0	0	1	0	0
TRIM25	7706	broad.mit.edu	37	17	54969126	54969126	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:54969126C>G	uc002iut.3	-	8	1888	c.1828G>C	c.(1828-1830)Gct>Cct	p.A610P	TRIM25_uc010dcj.3_Missense_Mutation_p.A402P|TRIM25_uc021uaj.1_5'Flank	NM_005082	NP_005073	Q14258	TRI25_HUMAN	Homo sapiens tripartite motif containing 25 (TRIM25), mRNA.	610	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					GGGTACAAAGCCTCAGTAAAG	0.547000													97	61					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26964949	26964949	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:26964949G>C	uc002hbu.3	-	13	1779	c.1676C>G	c.(1675-1677)tCt>tGt	p.S559C		NM_014680	NP_055495	Q14667	K0100_HUMAN	Homo sapiens KIAA0100 (KIAA0100), mRNA.	559						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGAGTGCCTAGAGACAGCTGA	0.478000													4	167					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	118975229	118975229	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:118975229T>G	uc003ibx.3	+	1	567	c.164T>G	c.(163-165)cTc>cGc	p.L55R	NDST3_uc011cgf.1_Missense_Mutation_p.L55R|NDST3_uc003ibw.3_Missense_Mutation_p.L55R	NM_004784	NP_004775	O95803	NDST3_HUMAN	Homo sapiens N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 (NDST3), mRNA.	55	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						TGTGGCGACCTCCAACACCTA	0.443000													40	88					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44735723	44735723	+	Missense_Mutation	SNP	C	C	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:44735723C>A	uc003tln.3	+	12	1927	c.1768C>A	c.(1768-1770)Cct>Act	p.P590T	OGDH_uc011kbx.2_Missense_Mutation_p.P586T|OGDH_uc011kby.2_Missense_Mutation_p.P440T|OGDH_uc003tlp.3_Missense_Mutation_p.P601T|OGDH_uc011kbz.2_Missense_Mutation_p.P385T|OGDH_uc003tlo.1_Missense_Mutation_p.P423T	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	590					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CTCTCCCTGGCCTGGTGAGTG	0.438000													27	94					2.85442e-18	3.06277e-18	1	1	0
SOGA1	140710	broad.mit.edu	37	20	35438421	35438421	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr20:35438421C>G	uc021wcx.1	-	6	2887	c.2547G>C	c.(2545-2547)aaG>aaC	p.K849N	SOGA1_uc002xgd.1_Missense_Mutation_p.K611N	NM_080627	NP_542194	O94964	K0889_HUMAN	Homo sapiens KIAA0889 (KIAA0889), transcript variant 1, mRNA.	611										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						CGGCCTCCTCCTTTCGTAGCT	0.602000													20	35					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44735721	44735721	+	Missense_Mutation	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:44735721G>T	uc003tln.3	+	12	1925	c.1766G>T	c.(1765-1767)tGg>tTg	p.W589L	OGDH_uc011kbx.2_Missense_Mutation_p.W585L|OGDH_uc011kby.2_Missense_Mutation_p.W439L|OGDH_uc003tlp.3_Missense_Mutation_p.W600L|OGDH_uc011kbz.2_Missense_Mutation_p.W384L|OGDH_uc003tlo.1_Missense_Mutation_p.W422L	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	589					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	GACTCTCCCTGGCCTGGTGAG	0.438000													28	94					8.4185e-14	8.90302e-14	1	1	0
GNL2	29889	broad.mit.edu	37	1	38040324	38040324	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:38040324C>G	uc001cbk.3	-	10	1407	c.1244G>C	c.(1243-1245)tGg>tCg	p.W415S		NM_013285	NP_037417	Q13823	NOG2_HUMAN	Homo sapiens guanine nucleotide binding protein-like 2 (nucleolar) (GNL2), mRNA.	415					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				AGCATTCTCCCAAGAATCAAT	0.418000													33	36					0	0	1	0	0
BID	637	broad.mit.edu	37	22	18226632	18226632	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr22:18226632A>G	uc002znd.2	-	2	333	c.160T>C	c.(160-162)Tac>Cac	p.Y54H	BID_uc002znc.2_Missense_Mutation_p.Y100H|BID_uc021wko.1_Intron|BID_uc002zne.2_5'UTR|BID_uc021wkp.1_Intron|BID_uc002znf.2_Intron|BID_uc010gra.2_Non-coding_Transcript|BID_uc010grc.1_Intron|BID_uc010grb.1_Missense_Mutation_p.Y54H	NM_001196	NP_001187	P55957	BID_HUMAN	Homo sapiens BH3 interacting domain death agonist (BID), transcript variant 2, mRNA.	54					activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding			large_intestine(2)|ovary(1)	3		all_epithelial(15;0.198)		Lung(27;0.0419)		AGCTCATCGTAGCCCTCCCAC	0.632000													14	34					0	0	1	0	0
PUF60	22827	broad.mit.edu	37	8	144902839	144902839	+	Silent	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr8:144902839T>C	uc003yzs.3	-	4	409	c.345A>G	c.(343-345)caA>caG	p.Q115Q	PUF60_uc003yzq.3_Silent_p.Q72Q|PUF60_uc003yzr.3_Intron|PUF60_uc003yzt.3_Intron|PUF60_uc003yzu.1_Silent_p.Q104Q	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	Homo sapiens poly-U binding splicing factor 60KDa (PUF60), transcript variant 1, mRNA.	115	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				RNA splicing|apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|RNA binding|nucleotide binding|protein binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TATTGACCGATTGCAAAGGTG	0.562000													19	26					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72345617	72345617	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr18:72345617G>A	uc002llw.2	+	0	2695	c.2642G>A	c.(2641-2643)tGc>tAc	p.C881Y	ZNF407_uc010xfc.2_Missense_Mutation_p.C881Y|ZNF407_uc010dqu.2_Missense_Mutation_p.C881Y|ZNF407_uc002llu.2_Missense_Mutation_p.C880Y	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	Homo sapiens zinc finger protein 407 (ZNF407), transcript variant 1, mRNA.	881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGTTATTTATGCAAAGTGTGT	0.398000													30	78					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72345618	72345618	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr18:72345618C>T	uc002llw.2	+	0	2696	c.2643C>T	c.(2641-2643)tgC>tgT	p.C881C	ZNF407_uc010xfc.2_Silent_p.C881C|ZNF407_uc010dqu.2_Silent_p.C881C|ZNF407_uc002llu.2_Silent_p.C880C	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	Homo sapiens zinc finger protein 407 (ZNF407), transcript variant 1, mRNA.	881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GTTATTTATGCAAAGTGTGTA	0.403000													29	76					0	0	1	0	0
C2orf81	388963	broad.mit.edu	37	2	74643027	74643027	+	Silent	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:74643027G>T	uc010yrq.1	-	2	595	c.286C>A	c.(286-288)Cgg>Agg	p.R96R	DQ588163_uc002sla.3_Non-coding_Transcript	NM_001145054	NP_001138526			Homo sapiens chromosome 2 open reading frame 81 (C2orf81), mRNA.											endometrium(3)|kidney(1)	4						ATGGCCTCCCGGGCCTGGCTG	0.652000													42	57					2.77807e-22	3.00277e-22	1	1	0
MPRIP	23164	broad.mit.edu	37	17	17075111	17075111	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:17075111G>A	uc002gqy.2	+	1	3336	c.2930G>A	c.(2929-2931)cGg>cAg	p.R977Q	MPRIP_uc002gqu.2_Missense_Mutation_p.R748Q|MPRIP_uc002gqv.2_Missense_Mutation_p.R748Q|MPRIP_uc002gqw.2_Missense_Mutation_p.R503Q|MPRIP_uc002gqx.2_Missense_Mutation_p.R977Q|MPRIP_uc010cpl.2_5'Flank|MPRIP_uc010cpm.2_5'Flank			Q6WCQ1	MPRIP_HUMAN	Homo sapiens myosin phosphatase Rho interacting protein (MPRIP), transcript variant 1, mRNA.	748						cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						CAGCACCAGCGGGAGCTAGAG	0.572000													120	80					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21508090	21508090	+	Silent	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr18:21508090T>C	uc002kuq.3	+	62	8267	c.8181T>C	c.(8179-8181)ttT>ttC	p.F2727F	LAMA3_uc002kur.3_Silent_p.F2671F|LAMA3_uc002kus.4_Silent_p.F1118F|LAMA3_uc002kut.4_Silent_p.F1062F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 1, mRNA.	2727	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAATCAGATTTAACATTTCTA	0.408000													40	73					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104444950	104444950	+	Missense_Mutation	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr8:104444950G>T	uc003yln.3	+	6	1499	c.1222G>T	c.(1222-1224)Gca>Tca	p.A408S	DCAF13_uc003ylm.1_Missense_Mutation_p.A141S	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	Homo sapiens DDB1 and CUL4 associated factor 13 (DCAF13), mRNA.	256					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						CATTTTTACAGCAGCAAATGA	0.308000													4	9					0.184627	0.184627	1	1	0
SKAP2	8935	broad.mit.edu	37	7	26729973	26729973	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:26729973C>G	uc003syc.3	-	9	1098	c.805G>C	c.(805-807)Gag>Cag	p.E269Q	SKAP2_uc011jzi.2_Missense_Mutation_p.E97Q|SKAP2_uc011jzj.2_Missense_Mutation_p.E254Q	NM_003930	NP_003921	O75563	SKAP2_HUMAN	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), mRNA.	269					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						GCACTGTCCTCTTCTTCTTCT	0.388000													33	128					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65412463	65412463	+	Missense_Mutation	SNP	G	G	A	rs146916012		TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:65412463G>A	uc001ofb.2	+	4	1189	c.1022G>A	c.(1021-1023)cGg>cAg	p.R341Q	SIPA1_uc010rom.1_Missense_Mutation_p.R341Q|SIPA1_uc001ofd.2_Missense_Mutation_p.R341Q	NM_006747	NP_694985	Q96FS4	SIPA1_HUMAN	Homo sapiens signal-induced proliferation-associated 1 (SIPA1), transcript variant 2, mRNA.	341	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						CTGTACTGCCGGGCGGGCCAG	0.622000													68	75					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152235994	152235994	+	Missense_Mutation	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:152235994A>T	uc002txk.3	+	5	856	c.781A>T	c.(781-783)Act>Tct	p.T261S	FW340097_uc021vqy.1_5'Flank	NM_007115	NP_009046	P98066	TSG6_HUMAN	Homo sapiens tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), mRNA.	261					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		AAATACAAGTACTACTTCTAC	0.333000													35	37					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45107950	45107950	+	Silent	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr21:45107950C>G	uc002zdk.3	+	12	1809	c.1695C>G	c.(1693-1695)ccC>ccG	p.P565P	RRP1B_uc002zdl.3_Silent_p.P98P	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	Homo sapiens ribosomal RNA processing 1 homolog B (S. cerevisiae) (RRP1B), mRNA.	565					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		CCACGCTGCCCCAGCGCAGGA	0.632000													15	15					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113697143	113697143	+	Missense_Mutation	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr3:113697143A>C	uc003eax.3	-	15	2643	c.2496T>G	c.(2494-2496)ttT>ttG	p.F832L	KIAA1407_uc011bin.1_Non-coding_Transcript	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	Homo sapiens KIAA1407 (KIAA1407), mRNA.	832										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						AATGTACACAAAATTTTCTTA	0.393000													19	31					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39709737	39709737	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:39709737T>C	uc001rly.3	-	29	4364	c.3944A>G	c.(3943-3945)cAc>cGc	p.H1315R	KIF21A_uc001rlv.3_Intron|KIF21A_uc001rlw.3_Missense_Mutation_p.H589R|KIF21A_uc001rlx.3_Missense_Mutation_p.H1302R|KIF21A_uc001rlz.3_Intron|KIF21A_uc010skl.2_Intron|KIF21A_uc001rlu.3_5'UTR	NM_001173464	NP_001166935	Q7Z4S6	KI21A_HUMAN	Homo sapiens kinesin family member 21A (KIF21A), transcript variant 1, mRNA.	1315					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				AAAGTACCTGTGTACCTCCGA	0.393000													231	187					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177089815	177089815	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:177089815G>C	uc003iuj.3	+	24	3403	c.3100G>C	c.(3100-3102)Gtt>Ctt	p.V1034L	WDR17_uc003ium.4_Intron|WDR17_uc003iul.2_Intron|WDR17_uc003iun.3_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	Homo sapiens WD repeat domain 17 (WDR17), transcript variant 1, mRNA.	1034										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTTTTGTTACGTTAACAGGAA	0.338000													27	39					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78010716	78010716	+	Missense_Mutation	SNP	C	C	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chrX:78010716C>A	uc022bzj.1	+	0	350	c.350C>A	c.(349-351)gCa>gAa	p.A117E	LPAR4_uc010nme.3_Missense_Mutation_p.A117E	NM_005296	NP_005287	Q99677	LPAR4_HUMAN	Homo sapiens lysophosphatidic acid receptor 4 (LPAR4), mRNA.	117						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TCTGGAACTGCATTCCTTACC	0.423000													74	16					1.72036e-36	1.87329e-36	1	1	0
SMARCA4	6597	broad.mit.edu	37	19	11134305	11134305	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr19:11134305A>G	uc010dxp.3	+	20	3331	c.2971A>G	c.(2971-2973)Aag>Gag	p.K991E	SMARCA4_uc010dxo.3_Missense_Mutation_p.K991E|SMARCA4_uc002mqf.4_Missense_Mutation_p.K991E|SMARCA4_uc002mqg.1_Missense_Mutation_p.K991E|SMARCA4_uc010dxq.3_Missense_Mutation_p.K991E|SMARCA4_uc010dxr.3_Missense_Mutation_p.K991E|SMARCA4_uc002mqj.4_Missense_Mutation_p.K991E|SMARCA4_uc010dxs.3_Missense_Mutation_p.K991E|SMARCA4_uc010dxt.1_Missense_Mutation_p.K211E|SMARCA4_uc002mqh.4_Missense_Mutation_p.K114E|SMARCA4_uc002mqi.1_Missense_Mutation_p.K194E	NM_001128844	NP_003063	P51532	SMCA4_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 2, mRNA.	991					chromatin remodeling|negative regulation of S phase of mitotic cell cycle|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|WINAC complex|nBAF complex|npBAF complex|nuclear chromatin	ATP binding|DNA binding|DNA-dependent ATPase activity|androgen receptor binding|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GTTGCCCGAAAAGGTGATGGA	0.607000			"""F, N, Mis"""		NSCLC								26	43					0	0	1	0	0
C9orf50	375759	broad.mit.edu	37	9	132377793	132377793	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr9:132377793T>C	uc004byc.4	-	3	1052	c.850A>G	c.(850-852)Acg>Gcg	p.T284A	C9orf50_uc022boo.1_Missense_Mutation_p.T283A	NM_199350	NP_955382	Q5SZB4	CI050_HUMAN	Homo sapiens chromosome 9 open reading frame 50 (C9orf50), mRNA.	284										central_nervous_system(1)|endometrium(4)|large_intestine(2)|ovary(1)|skin(1)|urinary_tract(1)	10		Ovarian(14;0.00556)				TAGCGGAGCGTTGTGTCCTGC	0.642000													17	33					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380539	108380539	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:108380539C>T	uc001pkk.3	-	5	5806	c.5695G>A	c.(5695-5697)Gaa>Aaa	p.E1899K	EXPH5_uc010rvz.2_Missense_Mutation_p.E1743K|EXPH5_uc010rvy.2_Missense_Mutation_p.E1711K	NM_015065	NP_055880	Q149M6	Q149M6_HUMAN	Homo sapiens exophilin 5 (EXPH5), mRNA.	1899					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTACATTTTCTAAGAAAGCT	0.413000													32	68					0	0	1	0	0
C6orf211	79624	broad.mit.edu	37	6	151790234	151790234	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr6:151790234G>A	uc003qok.1	+	4	1574	c.1315G>A	c.(1315-1317)Ggt>Agt	p.G439S	C6orf211_uc011ees.1_Missense_Mutation_p.G320S	NM_024573	NP_078849	Q9H993	CF211_HUMAN	Homo sapiens chromosome 6 open reading frame 211 (C6orf211), mRNA.	439							protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(7)	15			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		TCAGTACGATGGTCCCCTTTG	0.507000													21	35					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20164184	20164184	+	Missense_Mutation	SNP	C	C	G	rs146721823	by1000genomes	TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr3:20164184C>G	uc003cbq.3	+	8	1747	c.1301C>G	c.(1300-1302)tCt>tGt	p.S434C		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	Homo sapiens K(lysine) acetyltransferase 2B (KAT2B), mRNA.	434					N-terminal peptidyl-lysine acetylation|cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|PCAF complex|chromatin remodeling complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						ATGACTGATTCTCATGTTCTG	0.408000													3	92					0	0	1	0	0
TNPO1	3842	broad.mit.edu	37	5	72183032	72183032	+	Nonsense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr5:72183032T>G	uc003kck.4	+	11	1433	c.1286T>G	c.(1285-1287)tTa>tGa	p.L429*	TNPO1_uc011csj.1_Nonsense_Mutation_p.L379*|TNPO1_uc003kci.4_Nonsense_Mutation_p.L421*|TNPO1_uc003kcg.4_Nonsense_Mutation_p.L421*	NM_002270	NP_694858	Q92973	TNPO1_HUMAN	Homo sapiens transportin 1 (TNPO1), transcript variant 1, mRNA.	429					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		ATTTTGGTTTTAGGAGCAATT	0.358000													4	42					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30094389	30094389	+	Silent	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:30094389T>C	uc003taq.3	+	7	1263	c.861T>C	c.(859-861)acT>acC	p.T287T	PLEKHA8_uc022aba.1_Silent_p.T287T|PLEKHA8_uc003tan.3_Silent_p.T287T	NM_001197026	NP_001183955	Q96JA3	PKHA8_HUMAN	Homo sapiens pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 (PLEKHA8), transcript variant 1, mRNA.	287				T -> S (in Ref. 1; AAK55424).	protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						ATAACTTGACTCAGTCTGGAT	0.383000													100	149					0	0	1	0	0
SH3D19	152503	broad.mit.edu	37	4	152096316	152096316	+	Missense_Mutation	SNP	T	T	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:152096316T>A	uc010ipl.1	-	6	1290	c.200A>T	c.(199-201)gAg>gTg	p.E67V	SH3D19_uc003imc.2_Missense_Mutation_p.E67V|SH3D19_uc003ime.2_Missense_Mutation_p.E67V|SH3D19_uc010ipm.2_Missense_Mutation_p.E67V	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	Homo sapiens SH3 domain containing 19 (SH3D19), transcript variant 1, mRNA.	67					cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	Golgi apparatus|cytosol|nucleus|plasma membrane	proline-rich region binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(1)|skin(3)|urinary_tract(1)	20	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				AGAGTCCCACTCTCCAGAAGC	0.517000													21	32					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45682709	45682709	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:45682709G>A	uc002ilr.4	+	16	2109	c.1886G>A	c.(1885-1887)gGa>gAa	p.G629E	NPEPPS_uc010wkt.2_Missense_Mutation_p.G625E|NPEPPS_uc010wku.2_Missense_Mutation_p.G593E|NPEPPS_uc010wkv.2_Missense_Mutation_p.G183E|NPEPPS_uc002ils.1_Missense_Mutation_p.G62E	NM_006310	NP_006301	P55786	PSA_HUMAN	Homo sapiens aminopeptidase puromycin sensitive (NPEPPS), mRNA.	629					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						GCTCGAGCTGGAATCATTAGC	0.403000													6	86					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217285132	217285132	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:217285132G>A	uc002vgc.4	+	4	1303	c.973G>A	c.(973-975)Gct>Act	p.A325T	SMARCAL1_uc002vgd.4_Missense_Mutation_p.A325T|SMARCAL1_uc010fvg.3_Missense_Mutation_p.A325T	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1), transcript variant 1, mRNA.	325					DNA metabolic process|chromatin modification|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCTTCCATCAGCTCCATCCCT	0.562000									Schimke Immuno-Osseous Dysplasia				73	118					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27801772	27801772	+	Missense_Mutation	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:27801772A>T	uc002rkz.4	+	0	2384	c.2333A>T	c.(2332-2334)gAa>gTa	p.E778V		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	Homo sapiens chromosome 2 open reading frame 16 (C2orf16), mRNA.	778										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TTGCAGCCTGAAGAGACCTAT	0.403000													14	19					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066418	46066418	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr21:46066418G>A	uc002zfr.4	+	0	88	c.43G>A	c.(43-45)Gac>Aac	p.D15N	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198692	NP_941965	P60411	KR109_HUMAN	Homo sapiens keratin associated protein 10-11 (KRTAP10-11), mRNA.	15						keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						CGCTTACTCCGACTCCTGGCA	0.677000													30	43					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459932	107459932	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:107459932C>G	uc002tdq.3	-	1	621	c.502G>C	c.(502-504)Gtc>Ctc	p.V168L	ST6GAL2_uc002tdr.3_Missense_Mutation_p.V168L|ST6GAL2_uc002tds.3_Missense_Mutation_p.V168L	NM_001142351	NP_115917	Q96JF0	SIAT2_HUMAN	Homo sapiens ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2), transcript variant 2, mRNA.	168					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CTCCTCTGGACCTGTGCAGCC	0.662000													50	80					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38397069	38397069	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr9:38397069T>C	uc022bgy.1	+	0	1324	c.1324T>C	c.(1324-1326)Tat>Cat	p.Y442H	ALDH1B1_uc004aay.3_Missense_Mutation_p.Y442H	NM_000692	NP_000683	P30837	AL1B1_HUMAN	Homo sapiens aldehyde dehydrogenase 1 family, member B1 (ALDH1B1), nuclear gene encoding mitochondrial protein, mRNA.	442					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CAACACCAGGTATGGCCTGGC	0.552000													44	79					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94197565	94197565	+	Missense_Mutation	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr13:94197565A>T	uc001vlt.3	+	1	842	c.210A>T	c.(208-210)gaA>gaT	p.E70D	GPC6_uc010tig.1_Missense_Mutation_p.E70D|GPC6_uc001vlu.1_5'UTR	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	Homo sapiens glypican 6 (GPC6), mRNA.	70						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GCACCACAGAAATGGAAGACA	0.408000													33	40					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088357	43088357	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr10:43088357T>C	uc001jaf.1	-	4	2156	c.2041A>G	c.(2041-2043)Att>Gtt	p.I681V	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.I569V|ZNF33B_uc001jad.3_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	Homo sapiens zinc finger protein 33B (ZNF33B), mRNA.	681						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TCATGTAAAATAAGTCCTGAC	0.403000													27	40					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129747271	129747271	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:129747271G>A	uc001qfg.3	-	13	1717	c.1596C>T	c.(1594-1596)gaC>gaT	p.D532D	NFRKB_uc001qfi.3_Silent_p.D507D|NFRKB_uc001qfh.3_Silent_p.D530D|NFRKB_uc010sbw.1_Silent_p.D517D|NFRKB_uc009zcr.3_5'Flank	NM_006165	NP_006156	Q6P4R8	NFRKB_HUMAN	Homo sapiens nuclear factor related to kappaB binding protein (NFRKB), transcript variant 2, mRNA.	507					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding	p.T531A(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GCACCACATAGTCAGTTCTTC	0.507000													22	35					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71607375	71607375	+	Silent	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:71607375T>C	uc002shx.3	+	8	2612	c.2289T>C	c.(2287-2289)acT>acC	p.T763T	ZNF638_uc010fec.2_Silent_p.T869T|ZNF638_uc010yqw.1_Silent_p.T342T|ZNF638_uc002shw.3_Silent_p.T763T|ZNF638_uc002shz.3_Silent_p.T763T|ZNF638_uc002shy.3_Silent_p.T763T|ZNF638_uc002sia.3_Silent_p.T763T|ZNF638_uc002sib.1_Silent_p.T763T|U6_uc021vje.1_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	Homo sapiens zinc finger protein 638 (ZNF638), transcript variant 1, mRNA.	763					RNA splicing	cytoplasm|nuclear speck	RNA binding|double-stranded DNA binding|nucleotide binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AGAAAAAGACTTTAGAGTCAA	0.249000													31	45					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4164714	4164714	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr16:4164714G>A	uc002cvx.3	-	1	1269	c.730C>T	c.(730-732)Ctg>Ttg	p.L244L		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	244					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CACAAACTCAGGTACAAAGGT	0.552000													43	70					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65319017	65319017	+	Splice_Site	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:65319017A>T	uc001oej.3	-	9	1817	c.1548_splice	c.e9+1	p.S516_splice	LTBP3_uc001oeh.3_5'Flank|LTBP3_uc010roi.2_Splice_Site_p.S399_splice|LTBP3_uc001oei.3_Splice_Site_p.S516_splice|LTBP3_uc010roj.2_Splice_Site_p.S217_splice|LTBP3_uc010rok.1_Splice_Site_p.S427_splice|U7_uc021qll.1_5'Flank	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	Homo sapiens latent transforming growth factor beta binding protein 3 (LTBP3), transcript variant 1, mRNA.	516						extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						TCTCATACTCACTGAGTCCGT	0.592000													27	57					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31134006	31134006	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr10:31134006G>A	uc010qdz.2	-	7	2806	c.2371C>T	c.(2371-2373)Ctc>Ttc	p.L791F	ZNF438_uc001ivn.3_Missense_Mutation_p.L742F|ZNF438_uc010qdy.2_Missense_Mutation_p.L781F|ZNF438_uc001ivo.4_Missense_Mutation_p.L355F|ZNF438_uc009xlg.3_Missense_Mutation_p.L791F|ZNF438_uc001ivp.4_Missense_Mutation_p.L781F|ZNF438_uc010qea.2_Missense_Mutation_p.L791F|ZNF438_uc010qeb.2_Missense_Mutation_p.L791F	NM_182755	NP_001137241	Q7Z4V0	ZN438_HUMAN	Homo sapiens zinc finger protein 438 (ZNF438), transcript variant 2, mRNA.	791					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGGTGGAGGAGGTCCTCTTTC	0.537000													43	73					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45688	45688	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:45688C>T	uc010yim.2	-	0	901	c.698G>A	c.(697-699)gGg>gAg	p.G233E		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	Homo sapiens family with sequence similarity 110, member C (FAM110C), mRNA.	233						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GTTCTCCCTCCCCAGGGCCTC	0.682000													7	5					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39797627	39797627	+	Silent	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:39797627T>C	uc021olw.1	+	0	687	c.687T>C	c.(685-687)gcT>gcC	p.A229A	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdb.1_Intron	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	Homo sapiens microtubule-actin crosslinking factor 1 (MACF1), transcript variant 1, mRNA.	1794	Actin-binding.|CH 2.				Golgi to plasma membrane protein transport|Wnt receptor signaling pathway|cell cycle arrest|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|wound healing	Golgi apparatus|microtubule|ruffle membrane	ATPase activity|actin filament binding|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGAAGAGGCTGTAAGACATA	0.478000													72	105					0	0	1	0	0
ZSCAN12	9753	broad.mit.edu	37	6	28359289	28359289	+	Missense_Mutation	SNP	C	C	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr6:28359289C>G	uc011dlh.2	-	3	957	c.778G>C	c.(778-780)Gac>Cac	p.D260H	ZSCAN12_uc010jre.3_Non-coding_Transcript	NM_001163391	NP_001156863			Homo sapiens zinc finger and SCAN domain containing 12 (ZSCAN12), transcript variant 1, mRNA.											breast(2)|endometrium(3)|urinary_tract(1)	6						TCAGTATGGTCAGAGTTCTCA	0.433000													41	72					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110453596	110453596	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr8:110453596G>A	uc003yne.3	+	33	4296	c.4192G>A	c.(4192-4194)Ggg>Agg	p.G1398R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 (PKHD1L1), mRNA.	1398	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TACCAACAATGGGAAAGATTC	0.289000										HNSCC(38;0.096)			3	86					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233659498	233659498	+	Silent	SNP	T	T	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:233659498T>A	uc002vtj.4	+	14	1653	c.1386T>A	c.(1384-1386)ccT>ccA	p.P462P	GIGYF2_uc010zmj.1_Silent_p.P441P|GIGYF2_uc002vtg.2_Silent_p.P435P|GIGYF2_uc002vti.4_Silent_p.P441P|GIGYF2_uc002vtk.4_Silent_p.P441P|GIGYF2_uc002vth.4_Silent_p.P435P|GIGYF2_uc010zmk.2_Non-coding_Transcript|GIGYF2_uc010zml.1_Silent_p.P272P	NM_001103147	NP_001096617	Q6Y7W6	PERQ2_HUMAN	Homo sapiens GRB10 interacting GYF protein 2 (GIGYF2), transcript variant 1, mRNA.	441	Pro-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CGCAGATTCCTTCAGATACAG	0.478000													41	42					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68107797	68107797	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr8:68107797C>T	uc003xxi.3	+	30	3771	c.3740C>T	c.(3739-3741)aCt>aTt	p.T1247I	ARFGEF1_uc003xxl.1_Intron|CSPP1_uc003xxj.3_Missense_Mutation_p.T1212I|CSPP1_uc003xxk.3_Missense_Mutation_p.T867I|CSPP1_uc010lyw.3_3'UTR	NM_024790	NP_079066	Q1MSJ5	CSPP1_HUMAN	Homo sapiens centrosome and spindle pole associated protein 1 (CSPP1), mRNA.	1247						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGCACTTTCACTTGGCAGGGC	0.493000													60	127					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45277229	45277229	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:45277229G>C	uc001myq.2	-	1	523	c.397C>G	c.(397-399)Ctc>Gtc	p.L133V	SYT13_uc009yku.1_5'UTR	NM_020826	NP_001234916	Q7L8C5	SYT13_HUMAN	Homo sapiens synaptotagmin XIII (SYT13), transcript variant 1, mRNA.	133						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						TTCTGAGGGAGGATGAACAGC	0.592000													11	20					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100434294	100434294	+	Missense_Mutation	SNP	T	T	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:100434294T>C	uc003huw.3	+	1	418	c.56T>C	c.(55-57)aTt>aCt	p.I19T	C4orf17_uc003hux.3_Non-coding_Transcript	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	Homo sapiens chromosome 4 open reading frame 17 (C4orf17), mRNA.	19										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GGCAGCCATATTATGGCTAGA	0.468000													48	62					0	0	1	0	0
SPRYD4	283377	broad.mit.edu	37	12	56862411	56862411	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:56862411C>T	uc001sli.4	+	0	111	c.36C>T	c.(34-36)tgC>tgT	p.C12C	SPRYD4_uc010sqo.1_Silent_p.C12C	NM_207344	NP_997227	Q8WW59	SPRY4_HUMAN	Homo sapiens SPRY domain containing 4 (SPRYD4), mRNA.	12	B30.2/SPRY.					nucleus				kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)	7						TGCGCTTGTGCCGCTGGGGAG	0.567000													3	75					0	0	1	0	0
KCNJ13	3769	broad.mit.edu	37	2	233633228	233633228	+	Silent	SNP	A	A	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:233633228A>T	uc002vto.3	-	1	799	c.756T>A	c.(754-756)ccT>ccA	p.P252P	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.4_Intron|GIGYF2_uc002vti.4_Intron|GIGYF2_uc002vtk.4_Intron|GIGYF2_uc002vth.4_Intron|GIGYF2_uc010zmk.2_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.3_3'UTR|KCNJ13_uc002vtp.3_Silent_p.P252P|KCNJ13_uc021vyk.1_Silent_p.P172P	NM_001172417	NP_001165888	O60928	IRK13_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13), transcript variant 3, mRNA.	252						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(3)|large_intestine(2)|lung(2)|stomach(1)|urinary_tract(1)	9		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		GAGTAGCCAGAGGACTTGATG	0.443000													74	96					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25469542	25469542	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:25469542C>T	uc002rgc.3	-	9	1483	c.1226G>A	c.(1225-1227)tGg>tAg	p.W409*	DNMT3A_uc002rgd.3_Nonsense_Mutation_p.W409*|DNMT3A_uc010eyi.3_Non-coding_Transcript|DNMT3A_uc002rgb.3_Nonsense_Mutation_p.W220*	NM_022552	NP_783328	Q9Y6K1	DNM3A_HUMAN	Homo sapiens DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 3, mRNA.	409					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGGGCCCATTCAATCAT	0.647000			"""Mis, F, N, S"""		AML								35	47					0	0	1	0	0
FAM48B2	170067	broad.mit.edu	37	X	24329890	24329890	+	Missense_Mutation	SNP	G	G	C	rs150066125	by1000genomes	TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chrX:24329890G>C	uc011mjw.2	-	0	1543	c.1543C>G	c.(1543-1545)Cct>Gct	p.P515A		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	Homo sapiens family with sequence similarity 48, member B2 (FAM48B2), mRNA.	515										breast(1)|endometrium(4)|large_intestine(1)|liver(1)|lung(12)|ovary(2)|prostate(1)|skin(1)	23						gctaaagcaggagcagcagca	0.632000													4	96					0	0	1	0	0
NEK9	91754	broad.mit.edu	37	14	75558059	75558059	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr14:75558059G>A	uc001xrl.3	-	18	2510	c.2356C>T	c.(2356-2358)Cga>Tga	p.R786*	NEK9_uc001xrj.3_Nonsense_Mutation_p.R5*|NEK9_uc001xrk.3_Nonsense_Mutation_p.R286*	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	Homo sapiens NIMA (never in mitosis gene a)- related kinase 9 (NEK9), mRNA.	786	Interaction with NEK6.|Pro/Ser/Thr-rich.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity	p.R786Q(3)		endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		TCCATTCCTCGGTCTGCTTCC	0.567000													21	27					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116941337	116941337	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:116941337A>G	uc001ege.3	+	15	2558	c.2219A>G	c.(2218-2220)gAt>gGt	p.D740G	ATP1A1_uc010owv.1_Missense_Mutation_p.D709G|ATP1A1_uc010oww.2_Missense_Mutation_p.D740G|ATP1A1_uc010owx.2_Missense_Mutation_p.D709G|ATP1A1OS_uc009whb.2_Intron	NM_000701	NP_001153706	P05023	AT1A1_HUMAN	Homo sapiens ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, mRNA.	740					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	GCTGGCTCAGATGTGTCCAAG	0.493000													46	77					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99116859	99116859	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr10:99116859G>A	uc001knf.3	-	33	4025	c.3886C>T	c.(3886-3888)Cga>Tga	p.R1296*	RRP12_uc001kne.3_Nonsense_Mutation_p.R311*|RRP12_uc009xvl.3_Nonsense_Mutation_p.R413*|RRP12_uc009xvm.3_Nonsense_Mutation_p.R1014*|RRP12_uc010qou.2_Nonsense_Mutation_p.R1235*|RRP12_uc009xvn.3_Nonsense_Mutation_p.R1196*	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	Homo sapiens ribosomal RNA processing 12 homolog (S. cerevisiae) (RRP12), transcript variant 1, mRNA.	1296						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CCTCAGGGTCGACGATCCTTT	0.622000													23	25					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31251264	31251264	+	Silent	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr15:31251264G>C	uc001zfh.1	-	7	917	c.819C>G	c.(817-819)tcC>tcG	p.S273S	MTMR10_uc010azx.1_Silent_p.S25S|MTMR10_uc001zfi.1_Silent_p.S25S|MTMR10_uc001zfj.3_Silent_p.S191S	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	Homo sapiens myotubularin related protein 10 (MTMR10), mRNA.	273	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CAAAAGAATGGGAAAAGATCT	0.383000													32	41					0	0	1	0	0
GEMIN6	79833	broad.mit.edu	37	2	39008788	39008788	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:39008788C>T	uc002rrc.3	+	2	443	c.258C>T	c.(256-258)ttC>ttT	p.F86F	GEMIN6_uc002rrb.3_Non-coding_Transcript	NM_024775	NP_079051	Q8WXD5	GEMI6_HUMAN	Homo sapiens gem (nuclear organelle) associated protein 6 (GEMIN6), mRNA.	86					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding			kidney(1)|large_intestine(3)|pancreas(1)	5		all_hematologic(82;0.21)				TGCATTTGTTCACGTCTGGAG	0.478000													37	67					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534968	92534968	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:92534968G>A	uc001pdj.4	+	8	8806	c.8789G>A	c.(8788-8790)cGa>cAa	p.R2930Q		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	Homo sapiens FAT tumor suppressor homolog 3 (Drosophila) (FAT3), mRNA.	2930	Cadherin 27.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAAGTGTACCGAGGGAATGTG	0.552000										TCGA Ovarian(4;0.039)			5	168					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070173	141070173	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr9:141070173G>A	uc010ncq.3	+	3	1253	c.413G>A	c.(412-414)cGg>cAg	p.R138Q						Homo sapiens tubulin, beta pseudogene 5 (TUBBP5), non-coding RNA.																		GGTGAGCTGCGGGCGAGGACT	0.647000													3	21					0	0	1	0	0
SLC10A4	201780	broad.mit.edu	37	4	48487158	48487158	+	Splice_Site	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:48487158A>C	uc003gyc.2	+	2	1020	c.801_splice	c.e2+1	p.K267_splice		NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (SLC10A4), mRNA.	267						integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	6						TACATTGTGAAGGTAAGGCCC	0.522000													58	105					0	0	1	0	0
HSD17B8	7923	broad.mit.edu	37	6	33172821	33172821	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr6:33172821C>T	uc003odi.1	+	1	222	c.195C>T	c.(193-195)ccC>ccT	p.P65P	MIR219-1_uc003odj.1_5'Flank	NM_014234	NP_055049	Q92506	DHB8_HUMAN	Homo sapiens hydroxysteroid (17-beta) dehydrogenase 8 (HSD17B8), mRNA.	65					estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(2)	9					NADH(DB00157)	AGGGGCCGCCCCGAGGGAACC	0.706000													3	12					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223633	35223633	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:35223633C>T	uc001bxu.3	+	1	802	c.702C>T	c.(700-702)acC>acT	p.T234T	GJB5_uc021okz.1_Silent_p.T234T|GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	Homo sapiens gap junction protein, beta 5, 31.1kDa (GJB5), mRNA.	234					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				CCCACGGTACCACCTCTTCCT	0.572000													118	156					0	0	1	0	0
NPEPL1	79716	broad.mit.edu	37	20	57282247	57282247	+	Silent	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr20:57282247A>C	uc010zzs.1	+	6	986	c.891A>C	c.(889-891)gcA>gcC	p.A297A	NPEPL1_uc010zzr.2_Silent_p.A249A|NPEPL1_uc010gjo.2_Silent_p.A269A|NPEPL1_uc002xzp.3_Silent_p.A185A	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	Homo sapiens aminopeptidase-like 1 (NPEPL1), transcript variant 1, mRNA.	297					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			TCAGAGCCGCAATCAAGCAGG	0.687000													7	9					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212548558	212548558	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:212548558G>A	uc010pte.2	-	7	1219	c.1051C>T	c.(1051-1053)Cct>Tct	p.P351S	TMEM206_uc001hjc.4_Missense_Mutation_p.P290S	NM_001198862	NP_001185791	Q9H813	TM206_HUMAN	Homo sapiens transmembrane protein 206 (TMEM206), transcript variant 1, mRNA.	290						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TGGATGAAAGGATCTTTCCAT	0.318000													52	95					0	0	1	0	0
CHEK1	1111	broad.mit.edu	37	11	125497532	125497532	+	Missense_Mutation	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr11:125497532A>C	uc009zbo.3	+	2	993	c.96A>C	c.(94-96)gaA>gaC	p.E32D	CHEK1_uc010sbi.2_Missense_Mutation_p.E32D|CHEK1_uc010sbh.2_Intron|CHEK1_uc001qcf.4_Missense_Mutation_p.E32D|CHEK1_uc009zbp.3_Missense_Mutation_p.E32D|CHEK1_uc001qcg.4_Missense_Mutation_p.E32D	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 1, mRNA.	32	Protein kinase.				DNA repair|DNA replication|cellular response to mechanical stimulus|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		GAGTAACTGAAGAAGCAGTCG	0.328000								Other conserved DNA damage response genes					24	25					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235884164	235884164	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:235884164G>A	uc001hxj.2	-	39	9532	c.9357C>T	c.(9355-9357)ctC>ctT	p.L3119L	LYST_uc001hxi.2_Silent_p.L343L	NM_000081	NP_000072	Q99698	LYST_HUMAN	Homo sapiens lysosomal trafficking regulator (LYST), mRNA.	3119					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAAGATTAGGGAGGTTATTTG	0.328000													24	33					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195508501	195508501	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr3:195508501T>G	uc021xjp.1	-	1	10106	c.9950A>C	c.(9949-9951)gAc>gCc	p.D3317A	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_5'Flank|MUC4_uc021xjn.1_5'Flank|MUC4_uc021xjo.1_5'Flank|MUC4_uc021xjg.1_5'Flank|MUC4_uc021xjh.1_5'Flank|MUC4_uc021xji.1_5'Flank|MUC4_uc021xjj.1_5'Flank|MUC4_uc021xjk.1_5'Flank|MUC4_uc021xjl.1_5'Flank|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	100					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.V3305_S3320delVSTGHATPLLVTDASS(1)|p.V3305_S3336delVSTGHATPLLVTDASSASTGHATPLHVTSPSS(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGAGGAAGCGTCGGTGACAAG	0.577000													5	18					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182735	57182735	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:57182735G>A	uc003hbk.2	+	7	3458	c.3067G>A	c.(3067-3069)Gaa>Aaa	p.E1023K	KIAA1211_uc010iha.2_Missense_Mutation_p.E1016K|KIAA1211_uc011bzz.1_Missense_Mutation_p.E933K|KIAA1211_uc003hbm.1_Missense_Mutation_p.E909K	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	Homo sapiens KIAA1211 (KIAA1211), mRNA.	1023										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AGGCCCCGAGGAAAGGAAGGG	0.647000													15	34					0	0	1	0	0
PCGF2	7703	broad.mit.edu	37	17	36891628	36891628	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr17:36891628T>G	uc002hqp.1	-	10	1129	c.883A>C	c.(883-885)Acc>Ccc	p.T295P	CISD3_uc010wds.1_3'UTR	NM_007144	NP_009075	P35227	PCGF2_HUMAN	Homo sapiens polycomb group ring finger 2 (PCGF2), mRNA.	295	Pro/Ser-rich.				negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					GTAGGGTGGGTGGCTGGAGGC	0.682000											OREG0024367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	75					0	0	1	0	0
TAAR9	134860	broad.mit.edu	37	6	132859693	132859693	+	Missense_Mutation	SNP	A	A	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr6:132859693A>C	uc011eci.2	+	1	264	c.262A>C	c.(262-264)Agc>Cgc	p.S88R		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	Homo sapiens trace amine associated receptor 9 (gene/pseudogene) (TAAR9), mRNA.	89						plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		GATGCCCTTCAGCACAGTGAG	0.453000													5	205					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41599643	41599643	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr19:41599643T>G	uc002opt.3	+	5	949	c.940T>G	c.(940-942)Ttc>Gtc	p.F314V		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 13 (CYP2A13), mRNA.	314					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding	p.G313S(1)		breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	GCGCTACGGTTTCCTGCTGCT	0.567000													39	56					0	0	1	0	0
TSPYL6	388951	broad.mit.edu	37	2	54482521	54482521	+	Silent	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr2:54482521G>A	uc002rxr.2	-	0	889	c.768C>T	c.(766-768)ttC>ttT	p.F256F	ACYP2_uc002rxq.4_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	Homo sapiens TSPY-like 6 (TSPYL6), mRNA.	256					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						GGTGGTGGCGGAAAGCAGTGA	0.517000													3	96					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51294808	51294808	+	Silent	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr15:51294808T>G	uc001zyx.2	+	20	3470	c.3363T>G	c.(3361-3363)acT>acG	p.T1121T	AP4E1_uc021skz.1_Silent_p.T1046T|AP4E1_uc010bex.1_Non-coding_Transcript	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	Homo sapiens adaptor-related protein complex 4, epsilon 1 subunit (AP4E1), transcript variant 1, mRNA.	1121					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CCTGTTCTACTCTTCCTGACT	0.463000													52	43					0	0	1	0	0
C12orf57	113246	broad.mit.edu	37	12	7053729	7053729	+	Missense_Mutation	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:7053729G>T	uc009zfj.1	+	2	479	c.215G>T	c.(214-216)gGt>gTt	p.G72V	ATN1_uc001qrw.1_3'UTR|ATN1_uc001qrx.1_3'UTR|C12orf57_uc001qrz.3_Missense_Mutation_p.G48V|PTPN6_uc001qsa.1_5'Flank|PTPN6_uc010sfr.1_5'Flank			Q99622	C10_HUMAN	Homo sapiens chromosome 12 open reading frame 57 (C12orf57), mRNA.	48										kidney(1)|large_intestine(1)	2						AACGACATGGGTAAGATGCTG	0.627000											OREG0021642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	96	60					7.59108e-50	8.39014e-50	1	1	0
LCP2	3937	broad.mit.edu	37	5	169680134	169680134	+	Missense_Mutation	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr5:169680134C>T	uc003man.1	-	17	1441	c.1234G>A	c.(1234-1236)Gcg>Acg	p.A412T	LCP2_uc011des.1_Missense_Mutation_p.A207T|LCP2_uc011det.1_Missense_Mutation_p.A241T	NM_005565	NP_005556	Q13094	LCP2_HUMAN	Homo sapiens lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2), mRNA.	412					T cell receptor signaling pathway|immune response|platelet activation|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding	p.P411P(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		TCTTCCTCCGCGGGGGATGGG	0.458000													8	18					0	0	1	0	0
SLC7A5P2	387254	broad.mit.edu	37	16	21531293	21531293	+	Missense_Mutation	SNP	T	T	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr16:21531293T>G	uc002djd.3	-	0	473	c.394A>C	c.(394-396)Aag>Cag	p.K132Q	LOC23117_uc021tel.1_Intron|LOC100271836_uc002dja.3_Non-coding_Transcript					Homo sapiens solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 2 (SLC7A5P2), non-coding RNA.																		ATCCAGAGCTTGAGGAAGGCG	0.647000													7	207					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	882734	882734	+	Missense_Mutation	SNP	T	T	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:882734T>A	uc003gbm.4	-	10	1305	c.1106A>T	c.(1105-1107)cAg>cTg	p.Q369L	GAK_uc003gbn.4_Missense_Mutation_p.Q290L|GAK_uc010ibk.1_Missense_Mutation_p.Q263L|GAK_uc003gbl.4_Missense_Mutation_p.Q233L	NM_005255	NP_005246	O14976	GAK_HUMAN	Homo sapiens cyclin G associated kinase (GAK), mRNA.	369					cell cycle	Golgi apparatus|focal adhesion|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GCCATACGGCTGGTCGTACTC	0.662000													22	27					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178553061	178553061	+	Silent	SNP	G	G	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr5:178553061G>T	uc003mjw.3	-	17	2790	c.2688C>A	c.(2686-2688)gcC>gcA	p.A896A		NM_014244	NP_055059	O95450	ATS2_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2), transcript variant 1, mRNA.	896	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCGAGAGGGCGGCACAGAAGC	0.637000													19	37					3.01185e-09	3.16244e-09	1	1	0
PRRC2C	23215	broad.mit.edu	37	1	171506567	171506567	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:171506567A>G	uc010pmg.2	+	14	2719	c.2453A>G	c.(2452-2454)cAa>cGa	p.Q818R	PRRC2C_uc010pmh.2_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	Homo sapiens proline-rich coiled-coil 2C (PRRC2C), mRNA.	818							protein C-terminus binding										GCTGAGCCTCAACAAGCAACT	0.403000													46	70					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19504023	19504023	+	Missense_Mutation	SNP	G	G	C			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:19504023G>C	uc001bbi.3	-	18	2573	c.2569C>G	c.(2569-2571)Cgc>Ggc	p.R857G	UBR4_uc001bbm.1_Missense_Mutation_p.R68G	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA.	857					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGAAGGAGGCGAGCCAAGATA	0.498000													98	97					0	0	1	0	0
ADD1	118	broad.mit.edu	37	4	2916729	2916729	+	Missense_Mutation	SNP	A	A	G			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:2916729A>G	uc003gfq.3	+	12	2005	c.1817A>G	c.(1816-1818)tAc>tGc	p.Y606C	ADD1_uc003gfo.3_Missense_Mutation_p.Y606C|ADD1_uc003gfp.3_Missense_Mutation_p.Y575C|ADD1_uc003gfr.3_Missense_Mutation_p.Y575C|ADD1_uc003gfs.3_Missense_Mutation_p.Y606C	NM_014189	NP_054908	P35611	ADDA_HUMAN	Homo sapiens adducin 1 (alpha) (ADD1), transcript variant 2, mRNA.	575				A -> E (in Ref. 2; AAB05645).	actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	F-actin capping protein complex|cytosol|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTGGAGGAGTACCGCAGGGAG	0.587000													62	92					0	0	1	0	0
POLM	27434	broad.mit.edu	37	7	44114102	44114102	+	Missense_Mutation	SNP	G	G	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:44114102G>A	uc003tjt.3	-	6	955	c.863C>T	c.(862-864)aCc>aTc	p.T288I	POLM_uc003tju.3_Silent_p.H285H|POLM_uc003tjv.3_Non-coding_Transcript|POLM_uc003tjx.2_Silent_p.H242H|POLM_uc011kbt.1_5'UTR	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	Homo sapiens polymerase (DNA directed), mu (POLM), mRNA.	288					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(3)|skin(2)	22						CAGGACTGGGGTGCTCAGGTC	0.697000								DNA polymerases (catalytic subunits)					27	64					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42360768	42360768	+	Silent	SNP	C	C	T			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr14:42360768C>T	uc001wvm.3	+	3	2899	c.1701C>T	c.(1699-1701)agC>agT	p.S567S	LRFN5_uc010ana.3_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	Homo sapiens leucine rich repeat and fibronectin type III domain containing 5 (LRFN5), mRNA.	567						integral to membrane		p.V566F(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CCAAGGTTAGCAATGTTTATT	0.458000										HNSCC(30;0.082)			39	62					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	144615250	144615251	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr1:144615250_144615251insAA	uc009wig.1	+	2	310_311	c.116_117insAA	c.(115-117)agafs	p.R39fs	NBPF10_uc010oxo.1_Intron|NBPF10_uc010oxn.1_Intron|NBPF10_uc021oth.1_Intron|NBPF10_uc021otj.1_Intron|NBPF10_uc021oto.1_Intron|NBPF10_uc021otr.1_Intron|NBPF10_uc021ots.1_Intron|NBPF10_uc021otv.1_Intron|NBPF10_uc001ekk.1_Intron|NBPF10_uc010oyd.1_Intron|NBPF10_uc010oye.2_5'UTR|NBPF10_uc001eli.3_Non-coding_Transcript|NBPF10_uc009wii.1_5'UTR|NBPF10_uc009wif.1_Non-coding_Transcript|PFN1P2_uc001elf.4_5'Flank	NM_001037675	NP_001032764	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 9 (NBPF9), mRNA.	39										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ACCTCAAAGAGATGTTTTCTAA	0.460													2	4	---	---	---	---					
TBCK	93627	broad.mit.edu	37	4	107163709	107163709	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr4:107163709delC	uc010ilv.2	-	11	1453	c.1088delG	c.(1087-1089)ggtfs	p.G363fs	TBCK_uc003hyb.2_Frame_Shift_Del_p.G106fs|TBCK_uc003hye.2_Frame_Shift_Del_p.G324fs|TBCK_uc003hyc.2_Frame_Shift_Del_p.G300fs|TBCK_uc003hyd.2_Frame_Shift_Del_p.G191fs|TBCK_uc003hyf.2_Frame_Shift_Del_p.G363fs	NM_001163435	NP_001156908	Q8TEA7	TBCK_HUMAN	Homo sapiens TBC1 domain containing kinase (TBCK), transcript variant 1, mRNA.	363						intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						AAAGCTTTCACCATCCTCAAA	0.313													17	11	---	---	---	---					
EIF2AK1	27102	broad.mit.edu	37	7	6078295	6078296	+	Frame_Shift_Ins	INS	-	-	A	rs150001751		TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:6078295_6078296insA	uc003spp.3	-	9	1272_1273	c.1126_1127insT	c.(1126-1128)tacfs	p.Y376fs	EIF2AK1_uc003spq.3_Frame_Shift_Ins_p.Y375fs|EIF2AK1_uc011jwm.1_Frame_Shift_Ins_p.Y252fs	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1), transcript variant 1, mRNA.	376	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CATCAGGTGGTACTGTGCCTAG	0.505													20	117	---	---	---	---					
EIF2AK1	27102	broad.mit.edu	37	7	6078298	6078299	+	Frame_Shift_Ins	INS	-	-	A			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:6078298_6078299insA	uc003spp.3	-	9	1269_1270	c.1123_1124insT	c.(1123-1125)cagfs	p.Q375fs	EIF2AK1_uc003spq.3_Frame_Shift_Ins_p.Q374fs|EIF2AK1_uc011jwm.1_Frame_Shift_Ins_p.Q251fs	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1), transcript variant 1, mRNA.	375	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CAGGTGGTACTGTGCCTAGGAG	0.510													20	113	---	---	---	---					
NFE2L3	9603	broad.mit.edu	37	7	26224635	26224636	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:26224635_26224636delCT	uc003sxq.3	+	3	1589_1590	c.1317_1318delCT	c.(1315-1320)cactctfs	p.H439fs		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	Homo sapiens nuclear factor (erythroid-derived 2)-like 3 (NFE2L3), mRNA.	439					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						ATTCCTCTCACTCTGTGTGTGA	0.421													41	127	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149518533	149518533	+	Frame_Shift_Del	DEL	C	C	-	rs11353848		TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr7:149518533delC	uc010lpk.3	+	87	12593	c.12593delC	c.(12592-12594)tccfs	p.S4198fs	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	Homo sapiens SCO-spondin homolog (Bos taurus) (SSPO), mRNA.	4201	TSP type-1 19.				cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGCAGTCCCAGAGCCAG	0.711													9	8	---	---	---	---					
MKI67	4288	broad.mit.edu	37	10	129902143	129902143	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr10:129902143delG	uc001lke.3	-	12	8156	c.7961delC	c.(7960-7962)ccafs	p.P2654fs	MKI67_uc001lkf.3_Frame_Shift_Del_p.P2294fs|MKI67_uc009yav.1_Frame_Shift_Del_p.P2229fs|MKI67_uc009yaw.1_Frame_Shift_Del_p.P1804fs	NM_002417	NP_002408	P46013	KI67_HUMAN	Homo sapiens antigen identified by monoclonal antibody Ki-67 (MKI67), transcript variant 1, mRNA.	2654	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TACTGGGTTTGGTTTCTTCTT	0.522													50	68	---	---	---	---					
DDX12P	440081	broad.mit.edu	37	12	9573305	9573305	+	RNA	DEL	G	G	-			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr12:9573305delG	uc021qut.1	-	10		c.2093delC			DDX12P_uc001qvx.4_Intron|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.																		gagggagggagggagCCCCCA	0.582													14	36	---	---	---	---					
ANKLE1	126549	broad.mit.edu	37	19	17397488	17397501	+	Frame_Shift_Del	DEL	TGTGTGTGTGTGTT	TGTGTGTGTGTGTT	-	rs10606406		TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr19:17397488_17397501delTGTGTGTGTGTGTT	uc010xpn.1	+	7	2034_2047	c.1920_1933delTGTGTGTGTGTGTT	c.(1918-1935)tgtgtgtgtgtgtgtttgfs	p.C640fs	ANKLE1_uc010xpm.1_Non-coding_Transcript|ANKLE1_uc002nga.2_3'UTR|ANKLE1_uc010eao.1_3'UTR|ANKLE1_uc002nfy.2_3'UTR|ANKLE1_uc002nfz.2_3'UTR			Q8NAG6	ANKL1_HUMAN	Homo sapiens ankyrin repeat and LEM domain containing 1 (ANKLE1), mRNA.	0						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						tgtgtgtgtgtgtgtgtgtgtgtttgtgtgtgtg	0.528													12	13	---	---	---	---					
NEFH	4744	broad.mit.edu	37	22	29885599	29885604	+	In_Frame_Del	DEL	AGGAAG	AGGAAG	-			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr22:29885599_29885604delAGGAAG	uc003afo.3	+	3	2041_2046	c.1970_1975delAGGAAG	c.(1969-1977)aaggaagag>aag	p.EE658del	KIAA0845_uc003afp.3_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	Homo sapiens neurofilament, heavy polypeptide (NEFH), mRNA.	664	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						TCCCCAGAGAAGGAAGAGGCCAAGTC	0.558													29	206	---	---	---	---					
NEFH	4744	broad.mit.edu	37	22	29885622	29885623	+	In_Frame_Ins	INS	-	-	AGGAAG			TCGA-MH-A55Z-01A-11D-A26P-10	TCGA-MH-A55Z-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b19ec4cd-2876-4a2b-bcb9-b3c8db54fc15	3d292f02-ebb2-457b-b5a3-1590b60833a6	g.chr22:29885622_29885623insAGGAAG	uc003afo.3	+	3	2064_2065	c.1993_1994insAGGAAG	c.(1993-1995)aag>aAGGAAGag	p.665_666insEE	KIAA0845_uc003afp.3_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	Homo sapiens neurofilament, heavy polypeptide (NEFH), mRNA.	671	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GTCCCCTGAGAAGGCCAAGTCC	0.579													8	290	---	---	---	---					
