Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRK5	2869	broad.mit.edu	37	10	121212789	121212789	+	Splice_Site	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:121212789G>A	uc001led.3	+	15	1907	c.1674_splice	c.e15+1	p.Q558_splice	GRK5_uc009xzh.3_Splice_Site_p.Q423_splice	NM_005308	NP_005299	P34947	GRK5_HUMAN	Homo sapiens G protein-coupled receptor kinase 5 (GRK5), mRNA.	558					G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CAAGCGGCAGGTGAGACACCC	0.587000													7	36					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84240579	84240579	+	Missense_Mutation	SNP	C	C	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr4:84240579C>G	uc003hoj.4	-	2	516	c.417G>C	c.(415-417)aaG>aaC	p.K139N	HPSE_uc003hoi.3_Missense_Mutation_p.K139N|HPSE_uc011ccq.2_Non-coding_Transcript|HPSE_uc011ccr.2_Non-coding_Transcript|HPSE_uc011ccs.2_5'UTR|HPSE_uc003hok.4_Missense_Mutation_p.K139N|HPSE_uc011cct.2_Missense_Mutation_p.K139N|HPSE_uc021xpr.1_Missense_Mutation_p.K139N	NM_001098540	NP_006656	Q9Y251	HPSE_HUMAN	Homo sapiens heparanase (HPSE), transcript variant 2, mRNA.	139					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CCAACCGTAACTTCTCCTCCA	0.438000													16	75					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19285118	19285118	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:19285118C>A	uc002gvn.3	+	4	1888	c.1502C>A	c.(1501-1503)gCt>gAt	p.A501D	MAPK7_uc002gvo.3_Missense_Mutation_p.A362D|MAPK7_uc002gvq.3_Missense_Mutation_p.A501D|MAPK7_uc002gvp.3_Missense_Mutation_p.A501D	NM_139033	NP_620601	Q13164	MK07_HUMAN	Homo sapiens mitogen-activated protein kinase 7 (MAPK7), transcript variant 1, mRNA.	501	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|cell cycle|cell differentiation|innate immune response|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding	p.A501D(2)		autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CCCCTGGAGGCTCCTGAGCCT	0.672000													10	55					7.48243e-07	8.58779e-07	1	1	0
SLC47A1	55244	broad.mit.edu	37	17	19449787	19449787	+	Missense_Mutation	SNP	T	T	C			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:19449787T>C	uc002gvx.3	+	2	363	c.277T>C	c.(277-279)Tct>Cct	p.S93P	SLC47A1_uc010vyy.1_Non-coding_Transcript|SLC47A1_uc002gvy.1_Missense_Mutation_p.S93P|SLC47A1_uc010vyz.1_Intron|SLC47A1_uc010cqp.1_Missense_Mutation_p.S93P|SLC47A1_uc010cqq.1_5'Flank	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	Homo sapiens solute carrier family 47, member 1 (SLC47A1), mRNA.	93						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					ATTCGGCTTATCTTCTGCCTG	0.453000													25	105					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58079023	58079023	+	Missense_Mutation	SNP	G	G	C			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr16:58079023G>C	uc002ena.3	+	9	2656	c.1683G>C	c.(1681-1683)gaG>gaC	p.E561D		NM_002428	NP_002419	P51511	MMP15_HUMAN	Homo sapiens matrix metallopeptidase 15 (membrane-inserted) (MMP15), mRNA.	561					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						GCTGCCAGGAGCACGTGGAGC	0.682000													24	54					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104592776	104592776	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:104592776G>T	uc001kwg.3	-	4	1115	c.943C>A	c.(943-945)Ctg>Atg	p.L315M		NM_000102	NP_000093	P05093	CP17A_HUMAN	Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1), mRNA.	315					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	AGGAAGGCCAGGGTCCATTTA	0.547000													46	162					4.17463e-26	5.62183e-26	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130926698	130926698	+	Missense_Mutation	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:130926698G>A	uc001uil.2	-	7	1364	c.1148C>T	c.(1147-1149)aCg>aTg	p.T383M	RIMBP2_uc001uim.3_Missense_Mutation_p.T291M	NM_015347	NP_056162	O15034	RIMB2_HUMAN	Homo sapiens RIMS binding protein 2 (RIMBP2), mRNA.	383						cell junction|synapse		p.T383M(2)		NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CACCAGCAGCGTGCACTGCAG	0.637000													5	163					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74281093	74281093	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr15:74281093A>G	uc002awe.3	-	3	512	c.441T>C	c.(439-441)ttT>ttC	p.F147F	STOML1_uc002awf.3_Silent_p.F147F|STOML1_uc010bje.3_Silent_p.F147F|STOML1_uc010uld.2_Silent_p.F105F|STOML1_uc002awh.3_Silent_p.F97F|STOML1_uc002awg.3_Silent_p.F97F	NM_004809	NP_004800	Q9UBI4	STML1_HUMAN	Homo sapiens stomatin (EPB72)-like 1 (STOML1), mRNA.	147						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						CCCAGATGCGAAACTGGACAT	0.612000													11	46					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62271195	62271195	+	Splice_Site	SNP	T	T	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:62271195T>A	uc001dab.3	+	13	1740	c.1626_splice	c.e13+1	p.M542_splice	INADL_uc009waf.1_Splice_Site_p.M542_splice|INADL_uc001daa.2_Splice_Site_p.M542_splice|INADL_uc001dad.3_Splice_Site_p.M239_splice|INADL_uc001dac.3_Splice_Site	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	Homo sapiens InaD-like (Drosophila) (INADL), mRNA.	542					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TATGAAGTAATGGTATGTTAA	0.363000													3	34					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19377799	19377799	+	Missense_Mutation	SNP	G	G	A	rs149127676	byFrequency	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:19377799G>A	uc010tkp.2	+	0	206	c.206G>A	c.(205-207)cGa>cAa	p.R69Q		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily H, member 12 (OR11H12), mRNA.	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGACTGGCGACTTCACACT	0.423000													4	101					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062032	194062032	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr3:194062032C>A	uc003fts.3	-	1	1490	c.1400G>T	c.(1399-1401)aGc>aTc	p.S467I	CPN2_uc021xix.1_Missense_Mutation_p.S467I	NM_001080513	NP_001073982	P22792	CPN2_HUMAN	Homo sapiens carboxypeptidase N, polypeptide 2 (CPN2), mRNA.	467					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CAGATCCCAGCTGCCCCCTGC	0.667000													6	77					3.59834e-05	3.95035e-05	1	1	0
NLRP6	171389	broad.mit.edu	37	11	284253	284253	+	Missense_Mutation	SNP	A	A	G	rs150530901		TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:284253A>G	uc010qvs.2	+	5	2225	c.2225A>G	c.(2224-2226)gAc>gGc	p.D742G	NLRP6_uc010qvt.2_Missense_Mutation_p.D741G	NM_138329	NP_612202	P59044	NALP6_HUMAN	Homo sapiens NLR family, pyrin domain containing 6 (NLRP6), mRNA.	742						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		AAACTCCCTGACGCGGTCTGC	0.627000													20	50					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197791195	197791195	+	Splice_Site	SNP	T	T	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:197791195T>A	uc002utw.3	-	1	261	c.147_splice	c.e1+1	p.Q49_splice	PGAP1_uc002utx.3_Splice_Site|PGAP1_uc002uty.1_Splice_Site_p.Q49_splice|PGAP1_uc010zgv.1_Intron|PGAP1_uc010fsj.2_Intron	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	Homo sapiens post-GPI attachment to proteins 1 (PGAP1), mRNA.	49					C-terminal protein lipidation|attachment of GPI anchor to protein|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						GAACCTTACCTGATACTCCGG	0.562000													30	138					0	0	1	0	0
ENTPD7	57089	broad.mit.edu	37	10	101421214	101421214	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:101421214C>A	uc009xwl.3	+	3	381	c.26C>A	c.(25-27)tCc>tAc	p.S9Y	ENTPD7_uc001kqa.4_Missense_Mutation_p.S7Y|SLC25A28_uc001kpy.2_5'Flank	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	Homo sapiens ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7), mRNA.	7						cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		ATCAGTTTTTCCTACCTCTGC	0.428000													13	37					2.32078e-09	2.75764e-09	1	1	0
LEFTY1	10637	broad.mit.edu	37	1	226075306	226075306	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:226075306G>T	uc001hpo.3	-	2	610	c.530C>A	c.(529-531)gCc>gAc	p.A177D	PYCR2_uc010pvj.2_Silent_p.G285G|LEFTY1_uc009xej.2_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	Homo sapiens left-right determination factor 1 (LEFTY1), mRNA.	177					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					CACGTCGAAGGCCTTCCAGCC	0.701000													14	29					2.39187e-15	3.05796e-15	1	1	0
MC5R	4161	broad.mit.edu	37	18	13826448	13826448	+	Silent	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr18:13826448G>A	uc010xaf.2	+	0	906	c.684G>A	c.(682-684)gcG>gcA	p.A228A		NM_005913	NP_005904	P33032	MC5R_HUMAN	Homo sapiens melanocortin 5 receptor (MC5R), mRNA.	228				ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding	p.A228T(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CCAGCTCTGCGCGGCAGAGGA	0.617000													26	81					0	0	1	0	0
CTDNEP1	23399	broad.mit.edu	37	17	7147902	7147902	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:7147902A>G	uc002gfd.2	-	6	1022	c.642T>C	c.(640-642)ctT>ctC	p.L214L	GABARAP_uc002gfb.3_5'Flank|CTDNEP1_uc002gfe.2_Silent_p.L214L	NM_001143775	NP_056158	O95476	CNEP1_HUMAN	Homo sapiens CTD nuclear envelope phosphatase 1 (CTDNEP1), transcript variant 2, mRNA.	214	FCP1 homology.				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity			central_nervous_system(9)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAGGTTGAGAAGGGCTGTGT	0.522000													11	30					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48563956	48563956	+	Missense_Mutation	SNP	A	A	C			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:48563956A>C	uc003toq.2	+	53	14188	c.14164A>C	c.(14164-14166)Aac>Cac	p.N4722H	ABCA13_uc010kys.1_Missense_Mutation_p.N1797H|ABCA13_uc010kyt.1_Non-coding_Transcript|ABCA13_uc010kyu.1_Missense_Mutation_p.N452H	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 13 (ABCA13), mRNA.	4722	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGTGTTATACAACCTTAGTAA	0.363000													22	77					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070069	141070069	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr9:141070069C>T	uc010ncq.3	+	3	1149	c.309C>T	c.(307-309)ccC>ccT	p.P103P						Homo sapiens tubulin, beta pseudogene 5 (TUBBP5), non-coding RNA.																		GGTACGTGCCCCGCGCTGTGC	0.711000													4	60					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201175227	201175227	+	Missense_Mutation	SNP	C	C	A	rs832156	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:201175227C>A	uc001gwc.3	+	11	1336	c.1206C>A	c.(1204-1206)gaC>gaA	p.D402E	IGFN1_uc001gwb.3_Non-coding_Transcript	NM_001164586	NP_001158058			Homo sapiens immunoglobulin-like and fibronectin type III domain containing 1 (IGFN1), mRNA.											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGGATAAAGACCTTCAGTCCA	0.507000													4	96					0.00909568	0.00927943	1	1	0
ST8SIA2	8128	broad.mit.edu	37	15	93007417	93007417	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr15:93007417C>T	uc002bra.3	+	5	1085	c.930C>T	c.(928-930)atC>atT	p.I310I	ST8SIA2_uc002brb.3_Silent_p.I289I	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2), mRNA.	310					N-glycan processing|axon guidance|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			GCAAACAAATCTACCTCTACG	0.493000													12	44					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104590667	104590667	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:104590667C>T	uc001kwg.3	-	7	1491	c.1319G>A	c.(1318-1320)cGc>cAc	p.R440H	WBP1L_uc009xxg.1_Non-coding_Transcript	NM_000102	NP_000093	P05093	CP17A_HUMAN	Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1), mRNA.	440			R -> H (in AH5).		androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	TATACAGGAGCGAGGTCCTGC	0.597000													25	92					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447559	74447559	+	Missense_Mutation	SNP	A	A	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr16:74447559A>T	uc002fct.3	-	3	672	c.472T>A	c.(472-474)Tca>Aca	p.S158T	CLEC18B_uc002fcu.3_Missense_Mutation_p.S158T|CLEC18B_uc010vmu.1_Missense_Mutation_p.S78T|CLEC18B_uc010vmw.1_Missense_Mutation_p.S158T|CLEC18B_uc010vmv.1_5'Flank	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	Homo sapiens C-type lectin domain family 18, member B (CLEC18B), mRNA.	158	SCP.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGCTGGCTTGAGGTGGCCCAC	0.607000													14	156					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	G	T	rs148273194	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:12885289G>T	uc001auk.2	-	3	1018	c.822C>A	c.(820-822)ctC>ctA	p.L274L		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	Homo sapiens PRAME family member 11 (PRAMEF11), mRNA.	274								p.L274L(6)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGCACTGGGAGAGATGCTTCA	0.458000													3	24					0.004672	0.00481502	1	1	0
COPG1	22820	broad.mit.edu	37	3	128993744	128993744	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr3:128993744G>T	uc003els.3	+	21	2420	c.2320G>T	c.(2320-2322)Gca>Tca	p.A774S	COPG1_uc010htb.3_Missense_Mutation_p.A680S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	Homo sapiens coatomer protein complex, subunit gamma (COPG), mRNA.	774	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GAACTTCGAAGCAGCCTGGGA	0.458000													45	192					4.54978e-40	6.20984e-40	1	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18195097	18195097	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:18195097C>T	uc001mnv.1	+	0	714	c.294C>T	c.(292-294)ctC>ctT	p.L98L		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	Homo sapiens MAS-related GPR, member X4 (MRGPRX4), mRNA.	98						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GCAAAATCCTCGTTTCTGTGA	0.527000													27	130					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31471290	31471290	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr16:31471290G>T	uc010vfn.2	+	2	854	c.730G>T	c.(730-732)Gtg>Ttg	p.V244L	ARMC5_uc010vfo.2_Missense_Mutation_p.V181L|ARMC5_uc002ecc.3_Missense_Mutation_p.V149L|ARMC5_uc002eca.4_Missense_Mutation_p.V149L|ARMC5_uc002ecb.2_Missense_Mutation_p.V149L|ARMC5_uc010vfp.2_Missense_Mutation_p.V149L	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	Homo sapiens armadillo repeat containing 5 (ARMC5), transcript variant 1, mRNA.	149							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CCGGACCGAAGTGCGCAGACT	0.607000													3	19					0.004672	0.00481502	1	1	0
FLJ36000	284124	broad.mit.edu	37	17	21904204	21904204	+	RNA	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:21904204G>T	uc002gza.2	+	0		c.143G>T								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ctgccaggacggtgttcgggt	0.677000													4	77					0.150653	0.150653	1	1	0
C14orf80	283643	broad.mit.edu	37	14	105962371	105962371	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:105962371C>T	uc001yrm.3	+	5	966	c.839C>T	c.(838-840)cCc>cTc	p.P280L	C14orf80_uc001yrj.3_Intron|C14orf80_uc001yrk.3_Intron|C14orf80_uc001yrn.3_Intron|C14orf80_uc001yro.3_Intron|C14orf80_uc010tys.2_Intron	NM_001134875	NP_001128347	Q86SX3	CN080_HUMAN	Homo sapiens chromosome 14 open reading frame 80 (C14orf80), transcript variant 1, mRNA.	280										central_nervous_system(1)	1		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.239)		TGGGCAGCACCCTTGGATCCT	0.632000													12	19					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101241	27101241	+	Missense_Mutation	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:27101241A>G	uc001bmv.1	+	17	4896	c.4523A>G	c.(4522-4524)tAt>tGt	p.Y1508C	ARID1A_uc001bmt.1_Missense_Mutation_p.Y1507C|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Missense_Mutation_p.Y1125C|ARID1A_uc001bmx.1_Missense_Mutation_p.Y354C|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	1508					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding	p.Y1508*(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACCTATAATTATGCCAACAGG	0.572000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								18	41					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128993745	128993745	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr3:128993745C>A	uc003els.3	+	21	2421	c.2321C>A	c.(2320-2322)gCa>gAa	p.A774E	COPG1_uc010htb.3_Missense_Mutation_p.A680E	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	Homo sapiens coatomer protein complex, subunit gamma (COPG), mRNA.	774	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										AACTTCGAAGCAGCCTGGGAT	0.458000													44	192					2.75338e-15	3.47614e-15	1	1	0
NKD1	85407	broad.mit.edu	37	16	50583404	50583404	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr16:50583404C>T	uc002egg.2	+	2	354	c.130C>T	c.(130-132)Ccg>Tcg	p.P44S		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	Homo sapiens naked cuticle homolog 1 (Drosophila) (NKD1), mRNA.	44					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		ACAGCGCTGCCCGGGCGGTGT	0.692000													31	102					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43241557	43241557	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr21:43241557C>T	uc002yzq.1	-	22	3135	c.3024G>A	c.(3022-3024)ctG>ctA	p.L1008L	PRDM15_uc002yzo.3_Silent_p.L679L|PRDM15_uc002yzp.3_Silent_p.L699L|PRDM15_uc002yzr.1_Silent_p.L699L	NM_022115	NP_071398	P57071	PRD15_HUMAN	Homo sapiens PR domain containing 15 (PRDM15), transcript variant 1, mRNA.	1008					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TGATGTGCTTCAGGTACTCCT	0.612000													20	69					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833342	61833342	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:61833342C>A	uc001jky.3	-	36	7635	c.7297G>T	c.(7297-7299)Gac>Tac	p.D2433Y	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2433					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTATAAGAGTCATCAGATATG	0.418000													15	72					9.16793e-09	1.0767e-08	1	1	0
C2orf81	388963	broad.mit.edu	37	2	74642300	74642300	+	Missense_Mutation	SNP	T	T	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:74642300T>G	uc010yrq.1	-	3	1232	c.923A>C	c.(922-924)tAc>tCc	p.Y308S	DQ588163_uc002sla.3_5'Flank	NM_001145054	NP_001138526			Homo sapiens chromosome 2 open reading frame 81 (C2orf81), mRNA.											endometrium(3)|kidney(1)	4						CACAGAGGGGTAGGACACCAA	0.701000													7	89					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75902074	75902074	+	Missense_Mutation	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr5:75902074G>A	uc003kek.3	+	11	1525	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K	IQGAP2_uc010izv.2_5'Flank|IQGAP2_uc011csv.2_5'Flank|IQGAP2_uc003kel.3_5'Flank	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	Homo sapiens IQ motif containing GTPase activating protein 2 (IQGAP2), mRNA.	435					small GTPase mediated signal transduction	actin cytoskeleton	GTPase inhibitor activity|Ras GTPase activator activity|actin binding|calmodulin binding	p.E435D(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AAGCTGGAATGAAATTCAGAA	0.343000													20	74					0	0	1	0	0
C20orf62	140834	broad.mit.edu	37	20	43090732	43090732	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr20:43090732A>G	uc002xmb.3	-	1	371	c.306T>C	c.(304-306)tcT>tcC	p.S102S						RecName: Full=Uncharacterized protein C20orf62;											lung(1)	1						CAAAGGCTGAAGACAGGCAGG	0.552000													30	84					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855782	62855782	+	Silent	SNP	A	A	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:62855782A>T	uc002jey.2	-	10	5098	c.4482T>A	c.(4480-4482)atT>atA	p.I1494I	LRRC37A3_uc010wqg.1_Silent_p.I612I|LRRC37A3_uc002jex.1_Silent_p.I471I|LRRC37A3_uc010wqf.1_Silent_p.I532I|LRRC37A3_uc010dek.1_Silent_p.I500I|DQ578599_uc021ubv.1_5'Flank	NM_199340	NP_955372	O60309	L37A3_HUMAN	Homo sapiens leucine rich repeat containing 37, member A3 (LRRC37A3), mRNA.	1494						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TAACATGAGCAATGAGCCTTC	0.522000													72	269					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68181318	68181318	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:68181318G>T	uc001ont.3	+	11	2740	c.2665G>T	c.(2665-2667)Gtg>Ttg	p.V889L	LRP5_uc009ysg.3_Missense_Mutation_p.V299L	NM_002335	NP_002326	O75197	LRP5_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), mRNA.	889	Beta-propeller 3.				Wnt receptor signaling pathway involved in dorsal/ventral axis specification|adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTGGACTTCGTGATGGACAT	0.592000													18	39					1.87028e-06	2.12245e-06	1	1	0
LARP7	51574	broad.mit.edu	37	4	113568519	113568519	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr4:113568519C>A	uc003iaz.3	+	8	1297	c.832C>A	c.(832-834)Cag>Aag	p.Q278K	LARP7_uc003iay.3_Missense_Mutation_p.Q271K|LARP7_uc003iba.3_Missense_Mutation_p.Q192K|LARP7_uc003ibb.3_Missense_Mutation_p.Q271K	NM_016648	NP_057732	Q4G0J3	LARP7_HUMAN	Homo sapiens La ribonucleoprotein domain family, member 7 (LARP7), transcript variant 1, mRNA.	271	Lys-rich.				RNA processing	nucleoplasm|ribonucleoprotein complex	RNA binding|nucleotide binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		ACCCCAAAAGCAGTGCTCAAA	0.448000													15	103					2.32078e-09	2.75764e-09	1	1	0
DDX41	51428	broad.mit.edu	37	5	176940458	176940458	+	Missense_Mutation	SNP	C	C	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr5:176940458C>G	uc003mho.3	-	10	1147	c.1126G>C	c.(1126-1128)Gcc>Ccc	p.A376P	DDX41_uc003mhn.3_Missense_Mutation_p.A245P|DDX41_uc003mhp.3_Missense_Mutation_p.A245P|DDX41_uc003mhq.1_Missense_Mutation_p.A156P	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41), mRNA.	376	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|RNA binding|protein binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			GGCATGGTGGCACTGAAGAGC	0.612000													24	87					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007416	93007416	+	Missense_Mutation	SNP	T	T	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr15:93007416T>A	uc002bra.3	+	5	1084	c.929T>A	c.(928-930)aTc>aAc	p.I310N	ST8SIA2_uc002brb.3_Missense_Mutation_p.I289N	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2), mRNA.	310					N-glycan processing|axon guidance|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TGCAAACAAATCTACCTCTAC	0.493000													12	44					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33603471	33603471	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr19:33603471C>A	uc002nug.1	+	12	2158	c.1844C>A	c.(1843-1845)cCt>cAt	p.P615H	GPATCH1_uc002nuh.1_5'Flank	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	Homo sapiens G patch domain containing 1 (GPATCH1), mRNA.	615						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					GAGTGGCACCCTGACAAGCTT	0.413000													4	82					0.00024832	0.000269681	1	1	0
PATE4	399968	broad.mit.edu	37	11	125707761	125707761	+	Splice_Site	SNP	A	A	C	rs11220236	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:125707761A>C	uc001qcv.3	+	2	103	c.59_splice	c.e2-2	p.V20_splice	PATE4_uc009zbu.3_Intron	NM_001144874	NP_001138346	P0C8F1	PATE4_HUMAN	Homo sapiens prostate and testis expressed 4 (PATE4), mRNA.	20						acrosomal vesicle				breast(1)	1						TCCACCCTGCAGTTATGGGTC	0.428000													4	105					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190437577	190437577	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:190437577C>A	uc002uqp.4	-	3	733	c.382G>T	c.(382-384)Gtt>Ttt	p.V128F	SLC40A1_uc002uqq.2_Missense_Mutation_p.V128F	NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	Homo sapiens solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1), mRNA.	128					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CTTACGAGAACCCATCCATGG	0.393000													35	139					1.49673e-21	1.96325e-21	1	1	0
COX10	1352	broad.mit.edu	37	17	13980321	13980321	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:13980321A>G	uc002gof.4	+	2	651	c.447A>G	c.(445-447)caA>caG	p.Q149Q	COX10_uc010vvs.2_Intron|COX10_uc010vvt.2_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	Homo sapiens COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (COX10), nuclear gene encoding mitochondrial protein, mRNA.	149					heme O biosynthetic process|heme a biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		TGAAGCTGCAAGTGTATGATT	0.368000													18	74					0	0	1	0	0
DNAJC14	85406	broad.mit.edu	37	12	56217194	56217194	+	Missense_Mutation	SNP	C	C	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:56217194C>G	uc001shu.2	-	1	1562	c.1506G>C	c.(1504-1506)gaG>gaC	p.E502D	DNAJC14_uc001shx.1_Missense_Mutation_p.E502D|DNAJC14_uc009zob.1_Missense_Mutation_p.E502D	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 14 (DNAJC14), mRNA.	502	J.				protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						ACATCTCATACTCCTTTCGCT	0.463000													13	58					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201285751	201285751	+	Missense_Mutation	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:201285751G>A	uc001gwd.3	+	3	1023	c.772G>A	c.(772-774)Gat>Aat	p.D258N	PKP1_uc001gwe.3_Missense_Mutation_p.D258N|PKP1_uc009wzm.3_5'UTR	NM_000299	NP_000290	Q13835	PKP1_HUMAN	Homo sapiens plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) (PKP1), transcript variant 1b, mRNA.	258					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						GAGCTCCCAGGATGAGAAATA	0.537000													43	120					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715503	101715503	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:101715503G>T	uc001kqj.2	-	3	1820	c.1728C>A	c.(1726-1728)caC>caA	p.H576Q	DNMBP-AS1_uc001kqk.1_Non-coding_Transcript	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	Homo sapiens dynamin binding protein (DNMBP), mRNA.	576					intracellular signal transduction|regulation of Rho protein signal transduction	Golgi stack|cell junction|cytoskeleton|synapse	Rho guanyl-nucleotide exchange factor activity|protein binding			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGATTGAAAAGTGGCGTAAAA	0.507000													7	39					5.18039e-06	5.74967e-06	1	1	0
OC90	729330	broad.mit.edu	37	8	133041426	133041426	+	Splice_Site	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr8:133041426C>T	uc003ytg.2	-	12	1032	c.1032_splice	c.e12-1	p.R344_splice	OC90_uc011lix.1_Splice_Site_p.R344_splice	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	Homo sapiens otoconin 90 (OC90), mRNA.	360	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			ACAAGCAGCACCTAAGACCAA	0.552000													11	70					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33762727	33762727	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr20:33762727G>T	uc002xbt.3	+	1	477	c.293G>T	c.(292-294)cGc>cTc	p.R98L	EDEM2_uc010zuv.1_Intron	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	Homo sapiens protein C receptor, endothelial (PROCR), mRNA.	98					antigen processing and presentation|blood coagulation|immune response	MHC class I protein complex|integral to plasma membrane	receptor activity	p.R98L(4)		breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GGCCTCGTGCGCCTGGTGCAC	0.726000													9	48					0.000442599	0.000470553	1	1	0
SKAP2	8935	broad.mit.edu	37	7	26894415	26894415	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:26894415A>G	uc003syc.3	-	1	455	c.162T>C	c.(160-162)gaT>gaC	p.D54D	SKAP2_uc011jzi.2_5'UTR|SKAP2_uc011jzj.2_Silent_p.D39D	NM_003930	NP_003921	O75563	SKAP2_HUMAN	Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), mRNA.	54					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						TAGACTTTACATCTTTTATCT	0.284000													3	12					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149518182	149518182	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:149518182C>T	uc010lpk.3	+	86	12516	c.12516C>T	c.(12514-12516)tgC>tgT	p.C4172C	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	Homo sapiens SCO-spondin homolog (Bos taurus) (SSPO), mRNA.	4175	TSP type-1 19.				cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCACTCATGCGGGCCCAGAG	0.692000													6	25					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50716444	50716444	+	Splice_Site	SNP	T	T	C			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr22:50716444T>C	uc003bkv.4	-	32	4981	c.4888_splice	c.e32-1	p.G1630_splice	PLXNB2_uc003bkt.1_Splice_Site_p.G422_splice|PLXNB2_uc003bku.1_Splice_Site_p.G615_splice	NM_012401	NP_036533	O15031	PLXB2_HUMAN	Homo sapiens plexin B2 (PLXNB2), mRNA.	1630					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGTGTGCCCTGTGGGGGGGA	0.682000													13	83					0	0	1	0	0
SMYD5	10322	broad.mit.edu	37	2	73447218	73447218	+	Missense_Mutation	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:73447218A>G	uc002siw.2	+	2	274	c.245A>G	c.(244-246)gAg>gGg	p.E82G	SMYD5_uc010yre.1_5'UTR	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	Homo sapiens SMYD family member 5 (SMYD5), mRNA.	82							metal ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13						AAGGCAGAGGAGAATGCCCAG	0.562000													26	96					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132996502	132996502	+	Missense_Mutation	SNP	T	T	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr8:132996502T>G	uc003yte.3	+	14	1896	c.1692T>G	c.(1690-1692)aaT>aaG	p.N564K		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	Homo sapiens EFR3 homolog A (S. cerevisiae) (EFR3A), mRNA.	564						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			AACTGGCTAATGAAGAAGTAG	0.348000													14	50					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63283171	63283171	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:63283171C>A	uc001nxc.2	+	7	1194	c.853C>A	c.(853-855)Cag>Aag	p.Q285K	LGALS12_uc001nxa.2_Missense_Mutation_p.Q284K|LGALS12_uc001nxb.2_Missense_Mutation_p.Q275K|LGALS12_uc001nxd.2_Missense_Mutation_p.Q223K|LGALS12_uc001nxe.2_Missense_Mutation_p.Q214K|LGALS12_uc009yot.2_Missense_Mutation_p.Q244K	NM_001142535	NP_001136007	Q96DT0	LEG12_HUMAN	Homo sapiens lectin, galactoside-binding, soluble, 12 (LGALS12), transcript variant 1, mRNA.	284	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTTTTACCCCCAGAGATTCTT	0.552000													5	21					0.000602214	0.00063358	1	1	0
DCAF17	80067	broad.mit.edu	37	2	172333421	172333421	+	Silent	SNP	T	T	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:172333421T>A	uc002ugx.3	+	10	1470	c.1143T>A	c.(1141-1143)tcT>tcA	p.S381S	DCAF17_uc010zdq.2_Non-coding_Transcript|DCAF17_uc010zdr.2_Non-coding_Transcript|DCAF17_uc010fqf.2_Intron|DCAF17_uc010fqg.3_Silent_p.S101S	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	Homo sapiens DDB1 and CUL4 associated factor 17 (DCAF17), transcript variant 1, mRNA.	381						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus				endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						ATCAGATCTCTGAAGATTTTG	0.323000													21	78					0	0	1	0	0
GLS	2744	broad.mit.edu	37	2	191795284	191795284	+	Missense_Mutation	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:191795284A>G	uc002usf.2	+	12	1811	c.1547A>G	c.(1546-1548)cAc>cGc	p.H516R	GLS_uc002use.2_Missense_Mutation_p.H516R|GLS_uc002usg.1_Missense_Mutation_p.H177R|GLS_uc002ush.2_Missense_Mutation_p.H177R|GLS_uc010zgi.1_Missense_Mutation_p.H87R|GLS_uc010zgj.1_Missense_Mutation_p.H21R|GLS_uc021vud.1_5'Flank	NM_014905	NP_055720	O94925	GLSK_HUMAN	Homo sapiens glutaminase (GLS), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	516					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAGGGAATTCACTTTTGTCAC	0.383000													22	64					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145567075	145567075	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:145567075C>T	uc001eob.1	+	11	3031	c.2923C>T	c.(2923-2925)Cat>Tat	p.H975Y		NM_144698	NP_653299	Q8N283	ANR35_HUMAN	Homo sapiens ankyrin repeat domain 35 (ANKRD35), mRNA.	975										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACAGGAATCATCTACTGAA	0.473000													25	80					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48539795	48539795	+	Missense_Mutation	SNP	C	C	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:48539795C>G	uc010wmm.1	+	6	820	c.716C>G	c.(715-717)aCc>aGc	p.T239S	ACSF2_uc002iqu.2_Missense_Mutation_p.T214S|ACSF2_uc010wml.1_Missense_Mutation_p.T171S|ACSF2_uc010wmn.1_Missense_Mutation_p.T201S|ACSF2_uc010wmo.1_Missense_Mutation_p.T54S	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	Homo sapiens acyl-CoA synthetase family member 2 (ACSF2), mRNA.	214					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCAGATCTGACCACAGTCATC	0.617000													11	69					0	0	1	0	0
DDX54	79039	broad.mit.edu	37	12	113610195	113610195	+	Silent	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:113610195G>A	uc001tuq.4	-	10	1270	c.1242C>T	c.(1240-1242)agC>agT	p.S414S	DDX54_uc001tup.3_Silent_p.S414S	NM_001111322	NP_001104792	Q8TDD1	DDX54_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 (DDX54), transcript variant 1, mRNA.	414	Helicase C-terminal.				RNA processing|estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|RNA binding|estrogen receptor binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TGGCGGGGAAGCTGTAGTTGA	0.637000													57	110					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700735	192700735	+	Missense_Mutation	SNP	T	T	C	rs150423095	byFrequency	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:192700735T>C	uc002utb.3	-	1	1547	c.1192A>G	c.(1192-1194)Agc>Ggc	p.S398G		NM_004657	NP_004648	O95810	SDPR_HUMAN	Homo sapiens serum deprivation response (SDPR), mRNA.	398						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	AGCGCGTAGCTACCCTCATAG	0.602000													3	77					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94436380	94436380	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr4:94436380C>T	uc011cdt.2	+	12	2269	c.2011C>T	c.(2011-2013)Ctt>Ttt	p.L671F	GRID2_uc011cdu.2_Missense_Mutation_p.L576F	NM_001510	NP_001501	O43424	GRID2_HUMAN	Homo sapiens glutamate receptor, ionotropic, delta 2 (GRID2), mRNA.	671					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.L671I(2)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTCCAGGACCTTTCCAAGCA	0.418000													12	53					0	0	1	0	0
LYG2	254773	broad.mit.edu	37	2	99861727	99861727	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:99861727G>T	uc002szw.1	-	3	492	c.379C>A	c.(379-381)Cag>Aag	p.Q127K	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_Missense_Mutation_p.Q127K|LYG2_uc002szx.1_Missense_Mutation_p.Q127K	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	Homo sapiens lysozyme G-like 2 (LYG2), mRNA.	127					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|stomach(1)	12						CTAAATACCTGCATCAAGCCA	0.517000													3	55					0.150653	0.150653	1	1	0
KIAA1239	57495	broad.mit.edu	37	4	37447184	37447184	+	Missense_Mutation	SNP	G	G	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr4:37447184G>A	uc011bxz.2	+	6	3574	c.3574G>A	c.(3574-3576)Gtg>Atg	p.V1192M		NM_001144990	NP_001138462	Q9ULI1	K1239_HUMAN	Homo sapiens KIAA1239 (KIAA1239), mRNA.	1192										breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(2)|skin(2)	16						AGACAGTGAGGTGGTCAGCAT	0.468000													21	56					0	0	1	0	0
AK298596	0	broad.mit.edu	37	8	145662377	145662377	+	Splice_Site	SNP	A	A	C	rs2242270	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr8:145662377A>C	uc011llh.1	+	2		c.518_splice	c.e2+1		TONSL_uc011llg.2_Intron					Homo sapiens cDNA FLJ59042 complete cds.																		GTGTCCACCAAGGTGCGCCAG	0.627000													3	66					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100129912	100129912	+	Missense_Mutation	SNP	T	T	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr4:100129912T>A	uc003huo.2	-	5	835	c.741A>T	c.(739-741)ttA>ttT	p.L247F	LOC100507053_uc003hum.2_Intron|ADH6_uc011cef.1_Missense_Mutation_p.L38F|ADH6_uc003hup.4_Missense_Mutation_p.L247F|ADH6_uc010ile.3_Missense_Mutation_p.L247F	NM_001102470	NP_001095940	P28332	ADH6_HUMAN	Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 1, mRNA.	247					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TGGGTTTCTTTAAGTCCTGAG	0.443000													25	87					0	0	1	0	0
CYP2D7P1	1564	broad.mit.edu	37	22	42536651	42536651	+	Silent	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr22:42536651C>T	uc003bci.3	-	7	1341	c.960G>A	c.(958-960)aaG>aaA	p.K320K	CYP2D7P1_uc003bcg.3_Silent_p.K64K|CYP2D7P1_uc010gyv.3_Silent_p.K104K|CYP2D7P1_uc010gyw.3_Non-coding_Transcript|CYP2D7P1_uc021wqk.1_Non-coding_Transcript					Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1 (CYP2D7P1), non-coding RNA.											endometrium(1)	1						GGAAGGGCTTCTTCCAGACGG	0.607000													84	389					0	0	1	0	0
MIS18BP1	55320	broad.mit.edu	37	14	45693181	45693181	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:45693181C>T	uc001wwf.3	-	10	3068	c.2609G>A	c.(2608-2610)tGc>tAc	p.C870Y		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	Homo sapiens MIS18 binding protein 1 (MIS18BP1), mRNA.	870					CenH3-containing nucleosome assembly at centromere|cell division|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						ACCAGGTAAGCATTCTAAGGG	0.388000													8	28					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133041425	133041425	+	Splice_Site	SNP	A	A	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr8:133041425A>T	uc003ytg.2	-	12	1032	c.1032_splice	c.e12-1	p.R344_splice	OC90_uc011lix.1_Splice_Site_p.R344_splice	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	Homo sapiens otoconin 90 (OC90), mRNA.	360	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GACAAGCAGCACCTAAGACCA	0.552000													11	70					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7794342	7794342	+	Missense_Mutation	SNP	C	C	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:7794342C>G	uc002gjd.2	+	3	648	c.646C>G	c.(646-648)Cac>Gac	p.H216D	CHD3_uc002gje.2_Missense_Mutation_p.H157D|CHD3_uc002gjf.2_Missense_Mutation_p.H157D|CHD3_uc002gjg.1_5'UTR	NM_001005271	NP_001005271	Q12873	CHD3_HUMAN	Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 3, mRNA.	157	Poly-Ala.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	NuRD complex|microtubule organizing center	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				GGAGGATTACCACACGCTCAC	0.527000													34	110					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35602012	35602012	+	Missense_Mutation	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:35602012G>T	uc002hnm.3	-	19	2659	c.2468C>A	c.(2467-2469)cCc>cAc	p.P823H	ACACA_uc002hnk.3_Missense_Mutation_p.P745H|ACACA_uc002hnl.3_Missense_Mutation_p.P765H|ACACA_uc002hnn.3_Missense_Mutation_p.P823H|ACACA_uc002hno.3_Missense_Mutation_p.P860H|ACACA_uc010cuz.3_Missense_Mutation_p.P823H	NM_198836	NP_942135	Q13085	ACACA_HUMAN	Homo sapiens acetyl-CoA carboxylase alpha (ACACA), transcript variant 3, mRNA.	823					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	ATP binding|acetyl-CoA carboxylase activity|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	AACCTTGCTGGGGTTGTCCAG	0.498000													24	92					3.69857e-22	4.9152e-22	1	1	0
GKN1	56287	broad.mit.edu	37	2	69207170	69207170	+	Silent	SNP	A	A	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:69207170A>G	uc002sfc.3	+	4	546	c.483A>G	c.(481-483)acA>acG	p.T161T		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	Homo sapiens gastrokine 1 (GKN1), mRNA.	161	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						GGATTCCAACATACATGGCTG	0.507000													33	139					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229730727	229730727	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:229730727C>T	uc001htq.3	-	4	1253	c.1087G>A	c.(1087-1089)Gac>Aac	p.D363N		NM_014409	NP_055224	O75529	TAF5L_HUMAN	Homo sapiens TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa (TAF5L), transcript variant 1, mRNA.	363					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				ATGGACATGTCTTCAGAACAA	0.527000													5	65					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201438489	201438489	+	Silent	SNP	T	T	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:201438489T>G	uc002uvw.2	+	6	3533	c.3420T>G	c.(3418-3420)tcT>tcG	p.S1140S	SGOL2_uc010zhd.1_Silent_p.S1140S|SGOL2_uc010zhe.1_Silent_p.S1140S	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	Homo sapiens shugoshin-like 2 (S. pombe) (SGOL2), transcript variant 1, mRNA.	1140					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						GATCTTTGTCTGAGATACATT	0.343000													10	48					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155733245	155733245	+	Silent	SNP	C	C	T	rs117045670	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:155733245C>T	uc001flz.2	-	21	4681	c.4584G>A	c.(4582-4584)gaG>gaA	p.E1528E	GON4L_uc021paz.1_Intron|GON4L_uc009wrg.1_Non-coding_Transcript|GON4L_uc001fly.1_Silent_p.E1528E|GON4L_uc009wrh.1_Silent_p.E1528E|GON4L_uc001fma.1_Silent_p.E1528E|GON4L_uc001fmb.4_Silent_p.E724E	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	Homo sapiens gon-4-like (C. elegans) (GON4L), transcript variant 1, mRNA.	1528	Glu-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding	p.E1528E(2)		NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					cttcttcttcctcctcttctt	0.488000													3	21					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484075	43484075	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:43484075C>A	uc003tid.1	+	10	1909	c.1304C>A	c.(1303-1305)cCt>cAt	p.P435H	HECW1_uc011kbi.1_Missense_Mutation_p.P435H	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	Homo sapiens HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), mRNA.	435					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TCTGTGGGACCTGAAGGGGCT	0.627000													21	81					5.26018e-13	6.479e-13	1	1	0
IMMT	10989	broad.mit.edu	37	2	86371928	86371928	+	Missense_Mutation	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:86371928C>A	uc002sqz.4	-	14	2128	c.1740G>T	c.(1738-1740)atG>atT	p.M580I	IMMT_uc002sqy.4_Missense_Mutation_p.M321I|IMMT_uc010yte.2_Missense_Mutation_p.M533I|IMMT_uc002srb.4_Missense_Mutation_p.M569I|IMMT_uc002sra.4_Missense_Mutation_p.M579I|IMMT_uc010ytd.2_Missense_Mutation_p.M568I	NM_006839	NP_006830	Q16891	IMMT_HUMAN	Homo sapiens inner membrane protein, mitochondrial (IMMT), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	580						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						ATGAGGTCTTCATGCTGTACT	0.473000													19	45					6.33239e-15	7.89594e-15	1	1	0
LMAN1L	79748	broad.mit.edu	37	15	75111060	75111060	+	Splice_Site	SNP	G	G	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr15:75111060G>T	uc002ayt.1	+	5	500	c.498_splice	c.e5-1	p.G166_splice	LMAN1L_uc010bkd.2_Splice_Site_p.G94_splice|LMAN1L_uc010ulo.1_Splice_Site_p.G58_splice|LMAN1L_uc010bke.1_Splice_Site_p.G166_splice	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	Homo sapiens lectin, mannose-binding, 1 like (LMAN1L), mRNA.	166	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGCCCACAGGGATGGAGCTAG	0.577000													18	33					2.32416e-17	3.00949e-17	1	1	0
MRC2	9902	broad.mit.edu	37	17	60753774	60753774	+	Silent	SNP	C	C	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:60753774C>A	uc002jad.3	+	10	2118	c.1716C>A	c.(1714-1716)atC>atA	p.I572I	MRC2_uc010ddq.1_Non-coding_Transcript	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	Homo sapiens mannose receptor, C type 2 (MRC2), mRNA.	572	C-type lectin 3.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GCAGCCTCATCTACAACTGGG	0.607000													15	57					3.41278e-10	4.1529e-10	1	1	0
MSS51	118490	broad.mit.edu	37	10	75185982	75185982	+	Missense_Mutation	SNP	C	C	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr10:75185982C>T	uc009xrh.3	-	5	798	c.725G>A	c.(724-726)gGa>gAa	p.G242E	MSS51_uc001juc.3_Missense_Mutation_p.G219E|MSS51_uc001jud.3_Missense_Mutation_p.G219E|MSS51_uc009xrg.3_Intron	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	Homo sapiens zinc finger, MYND-type containing 17 (ZMYND17), mRNA.	219							zinc ion binding										CCTTGGCCGTCCTACACTGGC	0.552000													3	18					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	Frame_Shift_Ins	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:17034125_17034126insAGCT	uc001azn.1	-	2	478_479	c.364_365insAGCT	c.(364-366)tggfs	p.W122fs	ESPNP_uc010ocj.1_Frame_Shift_Ins_p.W52fs					Homo sapiens espin pseudogene (ESPNP), non-coding RNA.																		CAGCAGCAGCCAGCTGAGCACC	0.718													25	11	---	---	---	---					
SPRR3	6707	broad.mit.edu	37	1	152975659	152975682	+	In_Frame_Del	DEL	GAGCCAGGCTGTACCAAGGTCCCT	GAGCCAGGCTGTACCAAGGTCCCT	-	rs67156933	byFrequency	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr1:152975659_152975682delGAGCCAGGCTGTACCAAGGTCCCT	uc021ozo.1	+	0	163_186	c.163_186delGAGCCAGGCTGTACCAAGGTCCCT	c.(163-186)gagccaggctgtaccaaggtccctdel	p.EPGCTKVP95del	SPRR3_uc001fax.4_In_Frame_Del_p.EPGCTKVP95del|SPRR3_uc001faz.4_In_Frame_Del_p.EPGCTKVP95del|SPRR3_uc001fay.2_Splice_Site_p.K60_splice	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	Homo sapiens small proline-rich protein 3 (SPRR3), transcript variant 1, mRNA.	95	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity	p.E95G(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAGATTCCAGAGCCAGGCTGTACCAAGGTCCCTGAGCCAGGCT	0.562													15	98	---	---	---	---					
HEATR5B	54497	broad.mit.edu	37	2	37286106	37286107	+	Frame_Shift_Ins	INS	-	-	A			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:37286106_37286107insA	uc002rpp.1	-	12	1969_1970	c.1873_1874insT	c.(1873-1875)tgtfs	p.C625fs		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	Homo sapiens HEAT repeat containing 5B (HEATR5B), mRNA.	625							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TAGCTCAGGACAATGTGCAACG	0.347													56	226	---	---	---	---					
POLR1B	84172	broad.mit.edu	37	2	113330280	113330285	+	In_Frame_Del	DEL	CCAATG	CCAATG	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr2:113330280_113330285delCCAATG	uc002thw.2	+	12	2796_2801	c.2216_2221delCCAATG	c.(2215-2223)accaatgcc>acc	p.NA740del	POLR1B_uc010fkn.2_In_Frame_Del_p.NA684del|POLR1B_uc002thx.2_In_Frame_Del_p.NA601del|POLR1B_uc010fko.2_In_Frame_Del_p.NA557del|POLR1B_uc010fkp.2_In_Frame_Del_p.NA179del|POLR1B_uc002thy.2_In_Frame_Del_p.NA601del|POLR1B_uc010yxo.1_In_Frame_Del_p.NA517del	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	Homo sapiens polymerase (RNA) I polypeptide B, 128kDa (POLR1B), transcript variant 1, mRNA.	740					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						CCAATTGGGACCAATGCCATCGTTGC	0.393													9	112	---	---	---	---					
VPS8	23355	broad.mit.edu	37	3	184612489	184612503	+	Splice_Site	DEL	AGGGATCTTTTATTT	AGGGATCTTTTATTT	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr3:184612489_184612503delAGGGATCTTTTATTT	uc021xik.1	+	22	1870	c.1782_splice	c.e22-1	p.K594_splice	VPS8_uc003fpb.1_Splice_Site_p.K592_splice|VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Splice_Site_p.K21_splice	NM_001009921	NP_001009921	Q8N3P4	VPS8_HUMAN	Homo sapiens vacuolar protein sorting 8 homolog (S. cerevisiae) (VPS8), transcript variant 1, mRNA.	594							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTTCTGTTACAGGGATCTTTTATTTAGTCAGATGT	0.344													9	29	---	---	---	---					
CDH12	1010	broad.mit.edu	37	5	21751876	21751876	+	Frame_Shift_Del	DEL	T	T	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr5:21751876delT	uc010iuc.2	-	11	2813	c.2355delA	c.(2353-2355)gaafs	p.E785fs	CDH12_uc011cno.1_Frame_Shift_Del_p.E745fs|CDH12_uc003jgk.2_Frame_Shift_Del_p.E785fs|BC038535_uc003jgj.3_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	Homo sapiens cadherin 12, type 2 (N-cadherin 2) (CDH12), mRNA.	785					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TATAACTCTCTTCTTCGCCAA	0.428										HNSCC(59;0.17)			33	89	---	---	---	---					
KDM1B	221656	broad.mit.edu	37	6	18218101	18218101	+	Frame_Shift_Del	DEL	C	C	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr6:18218101delC	uc003nco.1	+	13	1836	c.1761delC	c.(1759-1761)gtcfs	p.V587fs	KDM1B_uc003ncn.1_Frame_Shift_Del_p.V558fs|KDM1B_uc003ncp.1_Frame_Shift_Del_p.V143fs|KDM1B_uc003ncq.1_Frame_Shift_Del_p.V143fs	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	Homo sapiens lysine (K)-specific demethylase 1B (KDM1B), mRNA.	790					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						AAGGAACCGTCTTTTTCGCTG	0.418													22	75	---	---	---	---					
FHL5	9457	broad.mit.edu	37	6	97053903	97053904	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr6:97053903_97053904delTG	uc003pos.2	+	4	876_877	c.460_461delTG	c.(460-462)tgtfs	p.C154fs	FHL5_uc003pot.2_Frame_Shift_Del_p.C154fs	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 1, mRNA.	154	LIM zinc-binding 2.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TTGTGTGCCATGTTTTGAGAAG	0.396													35	106	---	---	---	---					
TBP	6908	broad.mit.edu	37	6	170871038	170871040	+	In_Frame_Del	DEL	CAA	CAA	-	rs10592950		TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr6:170871038_170871040delCAA	uc003qxu.3	+	2	493_495	c.214_216delCAA	c.(214-216)caadel	p.Q95del	TBP_uc011ehf.2_In_Frame_Del_p.Q75del|TBP_uc003qxt.3_In_Frame_Del_p.Q95del|TBP_uc011ehg.1_In_Frame_Del_p.Q95del	NM_003194	NP_001165556	P20226	TBP_HUMAN	Homo sapiens TATA box binding protein (TBP), transcript variant 1, mRNA.	95	Poly-Gln.		Missing.		cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q72del(3)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		gcagcagcagcaacagcaacagc	0.567													9	58	---	---	---	---					
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:20824941_20824943delGCC	uc003suz.3	-	1	584_586	c.493_495delGGC	c.(493-495)ggcdel	p.G165del	SP8_uc003suy.3_In_Frame_Del_p.G147del|SP8_uc022aak.1_In_Frame_Del_p.G147del	NM_182700	NP_945194	Q8IXZ3	SP8_HUMAN	Homo sapiens Sp8 transcription factor (SP8), transcript variant 1, mRNA.	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G165delG(1)|p.G147delG(1)		NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGCGGAGGAgccgccgccgccg	0.729													7	22	---	---	---	---					
MEPCE	56257	broad.mit.edu	37	7	100028068	100028068	+	Frame_Shift_Del	DEL	G	G	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:100028068delG	uc003uuw.3	+	0	815	c.427delG	c.(427-429)gggfs	p.G143fs	ZCWPW1_uc003uut.3_5'Flank|ZCWPW1_uc011kjr.2_5'Flank|ZCWPW1_uc003uuu.1_5'Flank|ZCWPW1_uc011kjt.1_5'Flank|ZCWPW1_uc011kju.1_5'Flank|MEPCE_uc022ain.1_Intron|MEPCE_uc022aio.1_Intron|MEPCE_uc003uuv.3_Intron	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	Homo sapiens methylphosphate capping enzyme (MEPCE), transcript variant 1, mRNA.	143	Gly-rich.						methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCGGCCACCTGGGGGGGGCGG	0.692													2	4	---	---	---	---					
LAMB1	3912	broad.mit.edu	37	7	107592551	107592555	+	Frame_Shift_Del	DEL	TCACA	TCACA	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:107592551_107592555delTCACA	uc003vev.2	-	20	3426_3430	c.3265_3269delTGTGA	c.(3265-3270)tgtgacfs	p.C1089fs	LAMB1_uc003vew.2_Frame_Shift_Del_p.C1065fs	NM_002291	NP_002282	P07942	LAMB1_HUMAN	Homo sapiens laminin, beta 1 (LAMB1), mRNA.	1065	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGCACAGCGGTCACAGTTCTGCCCG	0.571													19	193	---	---	---	---					
LAMB1	3912	broad.mit.edu	37	7	107592557	107592562	+	In_Frame_Del	DEL	TTCTGC	TTCTGC	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:107592557_107592562delTTCTGC	uc003vev.2	-	20	3419_3424	c.3258_3263delGCAGAA	c.(3256-3264)gggcagaac>ggc	p.QN1087del	LAMB1_uc003vew.2_In_Frame_Del_p.QN1063del	NM_002291	NP_002282	P07942	LAMB1_HUMAN	Homo sapiens laminin, beta 1 (LAMB1), mRNA.	1063	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGGTCACAGTTCTGCCCGATCACAT	0.558													19	184	---	---	---	---					
MLL3	58508	broad.mit.edu	37	7	151919708	151919708	+	Frame_Shift_Del	DEL	T	T	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr7:151919708delT	uc003wla.3	-	20	3602	c.3383delA	c.(3382-3384)gacfs	p.D1128fs	MLL3_uc003wkz.3_Frame_Shift_Del_p.D189fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	1128					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AAAACCAATGTCTGCTACATT	0.358			N		medulloblastoma								59	278	---	---	---	---					
OSGIN2	734	broad.mit.edu	37	8	90936735	90936736	+	Frame_Shift_Ins	INS	-	-	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr8:90936735_90936736insT	uc003yeh.3	+	5	885_886	c.625_626insT	c.(625-627)ctafs	p.L209fs	OSGIN2_uc003yeg.3_Frame_Shift_Ins_p.L165fs	NM_001126111	NP_004328	Q9Y236	OSGI2_HUMAN	Homo sapiens oxidative stress induced growth inhibitor family member 2 (OSGIN2), transcript variant 1, mRNA.	165					germ cell development|meiosis					breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTTTAGGAGCCTAAAAGGGGAT	0.322													16	69	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651200	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCC	rs71025763		TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:1651199_1651200insGGCTGTGGCTCC	uc001lty.3	+	0	167_168	c.129_130insGGCTGTGGCTCC	c.(127-132)insGGCTGTGGCTCC	p.43_44insGCGS	MOB2_uc001ltq.2_Intron	NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	Homo sapiens keratin associated protein 5-5 (KRTAP5-5), mRNA.	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtggggg	0.713													20	73	---	---	---	---					
NUP98	4928	broad.mit.edu	37	11	3789956	3789956	+	Frame_Shift_Del	DEL	G	G	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr11:3789956delG	uc001lyh.3	-	7	1224	c.803delC	c.(802-804)acafs	p.T268fs	NUP98_uc001lyi.3_Frame_Shift_Del_p.T268fs|NUP98_uc001lyj.2_Frame_Shift_Del_p.T268fs|NUP98_uc001lyk.2_Frame_Shift_Del_p.T268fs	NM_016320	NP_057404	P52948	NUP98_HUMAN	Homo sapiens nucleoporin 98kDa (NUP98), transcript variant 1, mRNA.	268	Gly/Thr-rich.				DNA replication|carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|mitotic prometaphase|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|cytosol|nuclear membrane|nucleoplasm	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ACCTGGATTTGTTCCAAATCC	0.378			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								12	40	---	---	---	---					
RDH16	8608	broad.mit.edu	37	12	57346721	57346721	+	Frame_Shift_Del	DEL	A	A	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:57346721delA	uc001smi.4	-	2	798	c.626delT	c.(625-627)ttcfs	p.F209fs	RDH16_uc009zpa.3_Frame_Shift_Del_p.F64fs	NM_003708	NP_003699	O75452	RDH16_HUMAN	Homo sapiens retinol dehydrogenase 16 (all-trans) (RDH16), mRNA.	209					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						AGCAGTCTTGAAATAGCCAGG	0.507													31	60	---	---	---	---					
MON2	23041	broad.mit.edu	37	12	62954348	62954349	+	Frame_Shift_Ins	INS	-	-	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:62954348_62954349insT	uc001sre.3	+	25	3878_3879	c.3487_3488insT	c.(3487-3489)ctgfs	p.L1163fs	MON2_uc010ssn.2_Frame_Shift_Ins_p.L1163fs|MON2_uc009zqj.3_Frame_Shift_Ins_p.L1163fs|MON2_uc010ssl.2_Frame_Shift_Ins_p.L1091fs|MON2_uc010ssm.2_Frame_Shift_Ins_p.L1140fs|MON2_uc001srf.3_Frame_Shift_Ins_p.L926fs|MON2_uc001srg.3_Frame_Shift_Ins_p.L38fs	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	Homo sapiens MON2 homolog (S. cerevisiae) (MON2), mRNA.	1164					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TGAAGTATCTCTGGCTGCTCTG	0.411													11	33	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124824721	124824722	+	In_Frame_Ins	INS	-	-	GCCGCTGCT	rs72177573	by1000genomes	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr12:124824721_124824722insGCCGCTGCT	uc021rga.1	-	36	5655_5656	c.5538_5539insAGCAGCGGC	c.(5536-5541)insAGCAGCGGC	p.1846_1847insSSG	NCOR2_uc021rgb.1_In_Frame_Ins_p.1830_1831insSSG|NCOR2_uc010tbb.2_In_Frame_Ins_p.1839_1840insSSG|NCOR2_uc010tbc.2_In_Frame_Ins_p.1829_1830insSSG|NCOR2_uc021rgc.1_In_Frame_Ins_p.1829_1830insSSG|NCOR2_uc010tba.2_In_Frame_Ins_p.1847_1848insSSG|NCOR2_uc010tax.2_5'UTR	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	Homo sapiens nuclear receptor corepressor 2 (NCOR2), transcript variant 1, mRNA.	1850					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|Notch binding|histone deacetylase binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		cccccacccccgccgctgctgc	0.713													15	24	---	---	---	---					
DHRS4	10901	broad.mit.edu	37	14	24513024	24513024	+	Frame_Shift_Del	DEL	G	G	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:24513024delG	uc010alc.3	+	3	365	c.365delG	c.(364-366)agafs	p.R122fs	DHRS4_uc021rrd.1_Intron|DHRS4_uc021rrf.1_Intron|DHRS4_uc010tnu.2_Intron|DHRS4_uc021rrg.1_Intron|DHRS4_uc021rrh.1_Intron|DHRS4_uc021rri.1_Intron|DHRS4_uc021rrj.1_Intron	NM_001082488	NP_001075957	Q9BTZ2	DHRS4_HUMAN	Homo sapiens dehydrogenase/reductase (SDR family) member 4 like 1 (DHRS4L1), mRNA.	119						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	gaaaagaaaagagggttgttt	0.488													5	5	---	---	---	---					
ZBTB1	22890	broad.mit.edu	37	14	64989255	64989256	+	Frame_Shift_Ins	INS	-	-	T			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:64989255_64989256insT	uc021rul.1	+	0	1033_1034	c.1033_1034insT	c.(1033-1035)attfs	p.I345fs	ZBTB1_uc001xhh.4_Frame_Shift_Ins_p.I345fs|ZBTB1_uc010aqg.3_Frame_Shift_Ins_p.I345fs|ZBTB1_uc001xhi.2_Frame_Shift_Ins_p.I345fs|ZBTB1_uc021rum.1_5'Flank	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	Homo sapiens zinc finger and BTB domain containing 1 (ZBTB1), transcript variant 1, mRNA.	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		CTTTAACATTATTAAAGTTACT	0.347													36	117	---	---	---	---					
MTA1	9112	broad.mit.edu	37	14	105936238	105936239	+	Frame_Shift_Ins	INS	-	-	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr14:105936238_105936239insG	uc001yqx.3	+	19	2093_2094	c.1906_1907insG	c.(1906-1908)cggfs	p.R636fs	MTA1_uc001yqy.3_3'UTR|MTA1_uc021seq.1_Frame_Shift_Ins_p.R624fs|MTA1_uc001yrb.3_Frame_Shift_Ins_p.R401fs	NM_004689	NP_004680	Q13330	MTA1_HUMAN	Homo sapiens metastasis associated 1 (MTA1), transcript variant 1, mRNA.	636					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GCGCCTGATCCGGGGGGGCTCC	0.663													28	114	---	---	---	---					
CTRB1	1504	broad.mit.edu	37	16	75257061	75257061	+	Frame_Shift_Del	DEL	G	G	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr16:75257061delG	uc002fds.3	+	3	281	c.259delG	c.(259-261)gggfs	p.G87fs		NM_001906	NP_001897			Homo sapiens chymotrypsinogen B1 (CTRB1), mRNA.											central_nervous_system(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.166)		GGTCGTGGCTGGGGAGTTTGA	0.672													9	105	---	---	---	---					
ZZEF1	23140	broad.mit.edu	37	17	3910206	3910207	+	Frame_Shift_Ins	INS	-	-	G			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:3910206_3910207insG	uc002fxe.3	-	54	8927_8928	c.8863_8864insC	c.(8863-8865)cgcfs	p.R2955fs	AB062083_uc021tnv.1_5'Flank|ZZEF1_uc021tnw.1_Non-coding_Transcript	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	Homo sapiens zinc finger, ZZ-type with EF-hand domain 1 (ZZEF1), mRNA.	2955							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						ATTCCAGAGGCGGGTGGCCTTG	0.530													9	91	---	---	---	---					
MYH3	4621	broad.mit.edu	37	17	10558280	10558281	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr17:10558280_10558281delGG	uc002gmq.2	-	2	189_190	c.101_102delCC	c.(100-102)gccfs	p.A34fs		NM_002470	NP_002461	P11055	MYH3_HUMAN	Homo sapiens myosin, heavy chain 3, skeletal muscle, embryonic (MYH3), mRNA.	34	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						AATACGTCTTGGCATCAAAGGG	0.485													38	128	---	---	---	---					
LAMA3	3909	broad.mit.edu	37	18	21508155	21508158	+	Frame_Shift_Del	DEL	GATT	GATT	-			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr18:21508155_21508158delGATT	uc002kuq.3	+	62	8332_8335	c.8246_8249delGATT	c.(8245-8250)agattgfs	p.R2749fs	LAMA3_uc002kur.3_Frame_Shift_Del_p.R2693fs|LAMA3_uc002kus.4_Frame_Shift_Del_p.R1140fs|LAMA3_uc002kut.4_Frame_Shift_Del_p.R1084fs	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 1, mRNA.	2749	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTCGTTAGATTGAATGATACT	0.436													41	167	---	---	---	---					
IL12RB1	3594	broad.mit.edu	37	19	18194264	18194265	+	Frame_Shift_Ins	INS	-	-	G	rs113524129	byFrequency	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr19:18194264_18194265insG	uc002nhx.1	-	2	272_273	c.221_222insC	c.(220-222)ccgfs	p.P74fs	IL12RB1_uc002nhw.1_Frame_Shift_Ins_p.P34fs|IL12RB1_uc010xqb.1_Frame_Shift_Ins_p.P34fs|IL12RB1_uc002nhy.3_Frame_Shift_Ins_p.P34fs	NM_005535	NP_005526	P42701	I12R1_HUMAN	Homo sapiens interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1, mRNA.	34	Fibronectin type-III 1.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCGGATATGGCGGGTCCTGAAA	0.564													9	175	---	---	---	---					
TRPC4AP	26133	broad.mit.edu	37	20	33603843	33603844	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chr20:33603843_33603844insAA	uc002xbk.3	-	9	1351_1352	c.1317_1318insTT	c.(1315-1320)ctccatfs	p.L439fs	TRPC4AP_uc010zuq.2_Frame_Shift_Ins_p.L30fs|TRPC4AP_uc010zur.2_Frame_Shift_Ins_p.L400fs|TRPC4AP_uc002xbl.3_Frame_Shift_Ins_p.L431fs|TRPC4AP_uc002xbm.1_Frame_Shift_Ins_p.L439fs	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily C, member 4 associated protein (TRPC4AP), transcript variant 1, mRNA.	439					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TTGTGACCATGGAGGACAAGGG	0.500													32	111	---	---	---	---					
AVPR2	554	broad.mit.edu	37	X	153171162	153171163	+	Frame_Shift_Ins	INS	-	-	G	rs61733408	byFrequency	TCGA-PJ-A5Z8-01A-11D-A28G-10	TCGA-PJ-A5Z8-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8661bd12-fa20-4263-b1ab-034a4b225560	32a7ff68-4d91-4377-bc04-dd8688d15196	g.chrX:153171162_153171163insG	uc004fjh.4	+	1	374_375	c.202_203insG	c.(202-204)cggfs	p.R68fs	AVPR2_uc004fjg.4_Intron|AVPR2_uc004fji.3_Frame_Shift_Ins_p.R68fs	NM_000054	NP_000045	P30518	V2R_HUMAN	Homo sapiens arginine vasopressin receptor 2 (AVPR2), transcript variant 1, mRNA.	68					G-protein signaling, coupled to cAMP nucleotide second messenger|activation of adenylate cyclase activity|excretion|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	Golgi apparatus|endoplasmic reticulum|endosome|integral to plasma membrane	vasopressin receptor activity	p.R68W(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	26	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	GCGGGGCCGGCGGGGCCACTGG	0.688													9	109	---	---	---	---					
