Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NPHP4	261734	broad.mit.edu	37	1	5935081	5935081	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:5935081C>A	uc001alq.1	-	21	3163	c.2897G>T	c.(2896-2898)AGC>ATC	p.S966I		NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	966					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGCGATGCTCTCGGCCTT	0.642000													4	27					1.23904e-05	1.26704e-05	1	0
EXOSC10	5394	broad.mit.edu	37	1	11151235	11151235	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:11151235G>A	uc001asa.2	-	5	529	c.479C>T	c.(478-480)GCA>GTA	p.A160V	EXOSC10_uc001asb.2_Missense_Mutation_p.A160V|EXOSC10_uc009vmy.1_Missense_Mutation_p.A160V	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	160					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		ATATTCTGCTGCCTATGATCA	0.353000													14	67					0	0	0	0
MFN2	9927	broad.mit.edu	37	1	12056346	12056346	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:12056346G>A	uc001atn.3	+	5	898	c.445G>A	c.(445-447)GAG>AAG	p.E149K	MFN2_uc009vni.2_Missense_Mutation_p.E149K	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	149	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCTCCTTACCGAGGGCTCAGA	0.602000													6	44					0	0	0	0
GJB5	2709	broad.mit.edu	37	1	35223201	35223201	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:35223201C>T	uc001bxu.2	+	2	370	c.270C>T	c.(268-270)CTC>CTT	p.L90L	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	90	Helical; (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)				CCTCACTGCTCGTGGTCATGC	0.617000													17	69					0	0	0	0
LMO4	8543	broad.mit.edu	37	1	87805751	87805751	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:87805751C>T	uc001dmi.2	+	4	1135	c.355C>T	c.(355-357)CGG>TGG	p.R119W	LMO4_uc001dmj.2_Missense_Mutation_p.R119W	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	119	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		CTCTACCTGCCGGAATCGCCT	0.393000													25	113					0	0	0	0
PKN2	5586	broad.mit.edu	37	1	89279371	89279371	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:89279371T>C	uc001dmn.2	+	16	2576	c.2234T>C	c.(2233-2235)CTA>CCA	p.L745P	PKN2_uc010osp.1_Missense_Mutation_p.L729P|PKN2_uc010osq.1_Missense_Mutation_p.L588P|PKN2_uc009wcv.2_Missense_Mutation_p.L697P|PKN2_uc010osr.1_Missense_Mutation_p.L410P	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	745	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GGTGGGGACCTAATGATGCAC	0.408000													3	176					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94505666	94505666	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:94505666C>T	uc001dqh.2	-	24	3644	c.3540G>A	c.(3538-3540)TCG>TCA	p.S1180S		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1180	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AACCCTTAGACGAGCAGCTGC	0.572000											OREG0013610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99771596	99771596	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:99771596C>T	uc001dse.2	+	7	1428	c.1322C>T	c.(1321-1323)TCC>TTC	p.S441F	LPPR4_uc010oue.1_Missense_Mutation_p.S383F	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	441							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCTATGGATTCCGCTCGATCA	0.498000													18	75					0	0	0	0
ADORA3	140	broad.mit.edu	37	1	112031442	112031442	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:112031442G>A	uc001ebf.2	-	3	1429	c.662C>T	c.(661-663)ACT>ATT	p.T221I	ADORA3_uc001ebg.3_Missense_Mutation_p.T140I	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GCAGGACATAGTGACAATGAG	0.532000													12	36					0	0	0	0
MAN1A2	10905	broad.mit.edu	37	1	117984891	117984891	+	Silent	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:117984891C>G	uc001ehd.1	+	6	1615	c.894C>G	c.(892-894)CTC>CTG	p.L298L	MAN1A2_uc009whg.1_Silent_p.L88L	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	298	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		CTGAGAAACTCCTTCCTGCCT	0.343000													14	97					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145323663	145323663	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:145323663A>G	uc001end.3	+	29	3760	c.3725A>G	c.(3724-3726)AAG>AGG	p.K1242R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	1167											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGAATTAAAAAGGACGAAGAA	0.463000													6	773					0	0	0	0
Unknown	0	broad.mit.edu	37	1	148889598	148889598	+	RNA	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:148889598G>A	uc009wkv.1	+	7		c.685G>A								Homo sapiens cDNA, FLJ17483.																		CATGCAGTTCGTCAGAACTTA	0.353000													9	33					0	0	0	0
FLG2	388698	broad.mit.edu	37	1	152331346	152331346	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:152331346C>G	uc001ezw.3	-	2	88	c.15G>C	c.(13-15)TTG>TTC	p.L5F	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	5	S-100-like (By similarity).						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAACACTTCTCAAGAGGTCGG	0.393000													13	62					0	0	0	0
NUP210L	91181	broad.mit.edu	37	1	154029395	154029395	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:154029395C>G	uc001fdw.2	-	23	3208	c.3136G>C	c.(3136-3138)GAA>CAA	p.E1046Q	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.E1046Q	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1046						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATATAATTTTCAGAGTATTCG	0.343000													11	48					0	0	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154525286	154525286	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:154525286G>C	uc001fff.1	-	6	831	c.740C>G	c.(739-741)TCT>TGT	p.S247C		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	247							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACCGAGCCAGACACTGCACC	0.562000													9	50					0	0	0	0
RXRG	6258	broad.mit.edu	37	1	165398095	165398095	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:165398095G>C	uc001gda.2	-	2	458	c.158C>G	c.(157-159)CCA>CGA	p.P53R		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	53	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CAGAGTCCGTGGGGCACTCAC	0.617000													9	31					0	0	0	0
LHX4	89884	broad.mit.edu	37	1	180240979	180240979	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:180240979C>T	uc001goe.1	+	5	839	c.616C>T	c.(616-618)CAG>TAG	p.Q206*	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	206	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGTTTGGTTTCAGAACAGAAG	0.607000													25	113					0	0	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306592	205306592	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:205306592C>T	uc001hcf.1	-	6	1556	c.988G>A	c.(988-990)GCC>ACC	p.A330T	KLHDC8A_uc010prg.1_Missense_Mutation_p.A217T|KLHDC8A_uc001hcg.1_Missense_Mutation_p.A330T	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	330										ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCTCCCACGGCGAGGAGGCAG	0.597000													32	118					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228476582	228476582	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:228476582C>T	uc009xez.1	+	38	10376	c.10332C>T	c.(10330-10332)ACC>ACT	p.T3444T	OBSCN_uc001hsn.2_Silent_p.T3444T|OBSCN_uc001hsq.1_Silent_p.T700T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3444	Ig-like 34.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCACTCTCACCGTGAAGGGTA	0.612000													9	43					0	0	0	0
ITIH2	3698	broad.mit.edu	37	10	7774362	7774362	+	Missense_Mutation	SNP	C	T	T	rs150529114		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:7774362C>T	uc001ijs.2	+	14	1871	c.1709C>T	c.(1708-1710)TCG>TTG	p.S570L		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	570					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.S570L(1)		ovary(1)|pancreas(1)|skin(1)	3						GATTTTCTATCGAAAGACAAG	0.488000													4	27					0	0	0	0
RET	5979	broad.mit.edu	37	10	43606744	43606744	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:43606744G>A	uc001jal.2	+	7	1543	c.1353G>A	c.(1351-1353)ACG>ACA	p.T451T	RET_uc001jak.1_Silent_p.T451T|RET_uc010qez.1_Silent_p.T197T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	451	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACTGCAGCACGCTAGGGGTGG	0.582000		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				10	67					0	0	0	0
Unknown	0	broad.mit.edu	37	10	51808014	51808014	+	RNA	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:51808014G>A	uc001jiz.1	-	6		c.1839C>T								Homo sapiens cDNA FLJ31813 fis, clone NT2RI2009517.																		GGAGAGCTCGGAGGCTTTTGC	0.448000													31	118					0	0	0	0
POLR3A	11128	broad.mit.edu	37	10	79760814	79760814	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:79760814C>A	uc001jzn.2	-	18	2492	c.2398G>T	c.(2398-2400)GGA>TGA	p.G800*		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	800					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCCTGCTGTCCCACACAGGCA	0.443000													9	57					0.00448238	0.00450728	1	0
CEP55	55165	broad.mit.edu	37	10	95276830	95276830	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:95276830A>T	uc009xug.2	+	6	1000	c.818A>T	c.(817-819)CAA>CTA	p.Q273L	CEP55_uc001kiq.3_Missense_Mutation_p.Q273L	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	273	Potential.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				GAAGAAACCCAAAAAGAAGTT	0.358000													10	54					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95790868	95790868	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:95790868C>T	uc001kjk.2	+	2	699	c.65C>T	c.(64-66)GCC>GTC	p.A22V	PLCE1_uc010qnx.1_Missense_Mutation_p.A22V	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	22					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GTGGTTTCTGCCCAGTCGGCT	0.423000													3	51					0	0	0	0
FAM178A	55719	broad.mit.edu	37	10	102683830	102683830	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:102683830G>C	uc001krt.3	+	5	1614	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	FAM178A_uc001krr.1_Missense_Mutation_p.E358Q|FAM178A_uc001krs.2_Missense_Mutation_p.E358Q|FAM178A_uc001kru.1_Missense_Mutation_p.E293Q	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	358											0						AAAAGCAAGAGAGTCCTTCCT	0.398000													9	48					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103339236	103339236	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:103339236G>A	uc001ktg.1	-	8	2468	c.1702C>T	c.(1702-1704)CGA>TGA	p.R568*	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Nonsense_Mutation_p.R241*|POLL_uc001kte.1_Nonsense_Mutation_p.R260*|POLL_uc001kth.1_Nonsense_Mutation_p.R293*|POLL_uc001kti.1_Nonsense_Mutation_p.R568*|POLL_uc001ktj.1_Nonsense_Mutation_p.R568*|POLL_uc001ktf.2_Nonsense_Mutation_p.R476*|POLL_uc001ktk.1_Nonsense_Mutation_p.R307*|POLL_uc010qqa.1_Nonsense_Mutation_p.R307*|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Nonsense_Mutation_p.R568*|POLL_uc001ktl.2_Nonsense_Mutation_p.R480*|POLL_uc010qqc.1_Nonsense_Mutation_p.R260*	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	568					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GCAGGTTCTCGGTAGGGGAGG	0.647000								DNA_polymerases_(catalytic_subunits)					14	49					0	0	0	0
ADAM12	8038	broad.mit.edu	37	10	127726869	127726869	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:127726869G>A	uc001ljk.2	-	20	2712	c.2299C>T	c.(2299-2301)CAC>TAC	p.H767Y	ADAM12_uc010qul.1_Missense_Mutation_p.H718Y	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	767	Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TGGCCGAGGTGAGCCTGACAG	0.587000													3	18					0	0	0	0
OR51V1	283111	broad.mit.edu	37	11	5221401	5221401	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:5221401T>A	uc010qyz.1	-	1	530	c.530A>T	c.(529-531)TAC>TTC	p.Y177F		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAATGACAGTAATTAAAAAA	0.393000													18	64					0	0	0	0
APBB1	322	broad.mit.edu	37	11	6432243	6432243	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:6432243C>T	uc001mdb.1	-	2	435	c.335G>A	c.(334-336)GGC>GAC	p.G112D	APBB1_uc001mdc.1_Missense_Mutation_p.G112D|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	112					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTGTATCAGGCCTTTGGGGCC	0.632000													45	182					0	0	0	0
USP47	55031	broad.mit.edu	37	11	11971469	11971469	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:11971469A>G	uc001mjs.2	+	23	4145	c.3382A>G	c.(3382-3384)AAA>GAA	p.K1128E	USP47_uc001mjr.2_Missense_Mutation_p.K1060E|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1148					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TGTGTTTGCTAAAGGAATGAC	0.338000													6	36					0	0	0	0
USP47	55031	broad.mit.edu	37	11	11971484	11971484	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:11971484C>T	uc001mjs.2	+	23	4160	c.3397C>T	c.(3397-3399)CGG>TGG	p.R1133W	USP47_uc001mjr.2_Missense_Mutation_p.R1065W|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1153					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		AATGACTGTACGGCAATCAAA	0.358000													7	37					0	0	0	0
MICALCL	84953	broad.mit.edu	37	11	12345523	12345523	+	Splice_Site	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:12345523A>G	uc001mkg.1	+	5	1834	c.1543_splice	c.e5-2	p.E515_splice		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		TGGTTTTCATAGGAGAAGAAG	0.353000													3	77					0	0	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17140215	17140215	+	Silent	SNP	G	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:17140215G>T	uc001mmq.3	-	17	3078	c.3012C>A	c.(3010-3012)ATC>ATA	p.I1004I	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Silent_p.I624I|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1004					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GTGCTATCTGGATATTTCCCA	0.289000													29	120					7.01153e-11	7.33577e-11	1	0
USH1C	10083	broad.mit.edu	37	11	17548829	17548829	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:17548829G>A	uc001mnf.2	-	5	546	c.437C>T	c.(436-438)ACC>ATC	p.T146I	USH1C_uc001mne.2_Missense_Mutation_p.T146I|USH1C_uc009yhb.2_Missense_Mutation_p.T146I|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.T110I	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	146	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CTCCTCATGGGTACAGGAGGA	0.522000													13	68					0	0	0	0
OR5L2	26338	broad.mit.edu	37	11	55594821	55594821	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:55594821C>T	uc001nhy.1	+	1	127	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GTTAGCCAATCTGGGCATGAC	0.498000										HNSCC(27;0.073)			63	247					0	0	0	0
OR5D16	390144	broad.mit.edu	37	11	55606633	55606633	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:55606633G>A	uc010rio.1	+	1	406	c.406G>A	c.(406-408)GTT>ATT	p.V136I		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GCTCTACACAGTTGCCATCTC	0.453000													20	83					0	0	0	0
MMP13	4322	broad.mit.edu	37	11	102816405	102816405	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:102816405C>T	uc001phl.2	-	9	1313	c.1285G>A	c.(1285-1287)GAT>AAT	p.D429N		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	429	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TCTACTTTATCACCAATTCCT	0.338000													17	58					0	0	0	0
OR6M1	390261	broad.mit.edu	37	11	123676380	123676380	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:123676380G>A	uc010rzz.1	-	1	678	c.678C>T	c.(676-678)CCC>CCT	p.P226P		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CCTGGGTGGAGGGGATACGCA	0.498000													5	21					0	0	0	0
PARP11	57097	broad.mit.edu	37	12	3931108	3931108	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:3931108G>A	uc001qmk.1	-	5	513	c.458C>T	c.(457-459)ACG>ATG	p.T153M	PARP11_uc001qml.2_Missense_Mutation_p.T160M|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Missense_Mutation_p.T79M|PARP11_uc001qmn.2_Missense_Mutation_p.T79M	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	153	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			GCGATCCATCGTCTTCCCAAA	0.348000													19	72					0	0	0	0
IFFO1	25900	broad.mit.edu	37	12	6664531	6664531	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:6664531A>G	uc001qpd.1	-	1	699	c.665T>C	c.(664-666)GTG>GCG	p.V222A	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Missense_Mutation_p.V222A|IFFO1_uc001qpf.1_Missense_Mutation_p.V222A|IFFO1_uc001qpc.1_Missense_Mutation_p.V222A	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	222						intermediate filament					0						ATCCGGGTGCACCCACGACAA	0.682000													9	50					0	0	0	0
GPR162	27239	broad.mit.edu	37	12	6933294	6933294	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:6933294G>A	uc001qqw.1	+	2	765	c.230G>A	c.(229-231)CGT>CAT	p.R77H	GPR162_uc010sfn.1_Missense_Mutation_p.R77H|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	77	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGCTGCGTCGTCAGGCTTCC	0.602000													11	62					0	0	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48131465	48131465	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:48131465G>A	uc009zkp.2	-	27	2971	c.2531C>T	c.(2530-2532)TCG>TTG	p.S844L	uc001rpv.2_Intron|RAPGEF3_uc001rpw.2_Missense_Mutation_p.S179L|RAPGEF3_uc001rpx.2_Missense_Mutation_p.S301L|RAPGEF3_uc010sln.1_Missense_Mutation_p.S341L|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S844L|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S886L	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	844					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GGACTGCTCCGAGCCTGGTGG	0.602000													8	25					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49438595	49438595	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:49438595G>C	uc001rta.3	-	19	4895	c.4895C>G	c.(4894-4896)TCA>TGA	p.S1632*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1632					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AAGGGCATCTGAGGGCTCAGA	0.607000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	58					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49448693	49448693	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:49448693G>A	uc001rta.3	-	2	166	c.166C>T	c.(166-168)CAG>TAG	p.Q56*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	56					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGCAGTCCTGAGGAGTCTCC	0.522000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			40	139					0	0	0	0
SMARCD1	6602	broad.mit.edu	37	12	50480110	50480110	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:50480110C>T	uc001rvx.3	+	2	514	c.344C>T	c.(343-345)GCG>GTG	p.A115V	SMARCD1_uc010smo.1_Missense_Mutation_p.A115V|SMARCD1_uc001rvy.3_Missense_Mutation_p.A115V|SMARCD1_uc009zlp.2_Missense_Mutation_p.A115V	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	SWI/SNF-related matrix-associated	115	Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			ovary(1)	1						CAGCAGCAGGCGGTCCAAAAT	0.617000													7	24					0	0	0	0
CCDC64	92558	broad.mit.edu	37	12	120510422	120510422	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:120510422C>T	uc001txl.1	+	6	1222	c.1197C>T	c.(1195-1197)GAC>GAT	p.D399D	CCDC64_uc001txk.2_Silent_p.D399D|CCDC64_uc009zwv.1_Intron|CCDC64_uc010sze.1_Intron|CCDC64_uc010szf.1_Silent_p.D48D	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	399					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTCCATGGACGAGTCTTCAG	0.572000													13	50					0	0	0	0
MLEC	9761	broad.mit.edu	37	12	121125205	121125205	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:121125205G>A	uc001tyy.1	+	1	257	c.106G>A	c.(106-108)GTG>ATG	p.V36M		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	36	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						CGTggccggcgtggccggcgc	0.478000													4	6					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19414116	19414116	+	RNA	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:19414116C>T	uc010tcj.1	-	1		c.31994G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GATTGATTTACCTGATTTGGA	0.269000													4	10					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19415660	19415660	+	RNA	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:19415660C>A	uc010tcj.1	-	1		c.30450G>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						caaaacaaaaCAAAACAAACA	0.199000													5	44					7.48243e-07	7.695e-07	1	0
RB1	5925	broad.mit.edu	37	13	48954379	48954379	+	Splice_Site	SNP	T	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:48954379T>G	uc001vcb.2	+	16	1664	c.1498_splice	c.e16+2	p.R500_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CATATAGCAGTAAGTTAAATT	0.333000		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			4	10					0	0	0	0
PCCA	5095	broad.mit.edu	37	13	100915005	100915005	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:100915005C>G	uc001voo.2	+	10	777	c.739C>G	c.(739-741)CAA>GAA	p.Q247E	PCCA_uc010aga.2_Missense_Mutation_p.Q221E|PCCA_uc010tiz.1_Missense_Mutation_p.Q247E	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	247	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	ATTGTCATCTCAAGAAGCTGC	0.264000													30	136					0	0	0	0
PSMA6	5687	broad.mit.edu	37	14	35786477	35786477	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:35786477G>C	uc001wtd.2	+	7	815	c.706G>C	c.(706-708)GAT>CAT	p.D236H	KIAA0391_uc001wta.2_RNA|PSMA6_uc010tpt.1_Missense_Mutation_p.D157H|PSMA6_uc010tpu.1_Missense_Mutation_p.D157H	NM_002791	NP_002782	P60900	PSA6_HUMAN	proteasome alpha 6 subunit	236					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|purine ribonucleoside triphosphate binding|RNA binding|threonine-type endopeptidase activity				0	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		AGCAGAGATTGATGCTCACCT	0.323000													29	131					0	0	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68252948	68252948	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:68252948G>A	uc001xka.2	-	17	3161	c.3022C>T	c.(3022-3024)CGA>TGA	p.R1008*	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Nonsense_Mutation_p.R1008*	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1008					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCTATCCGTCGACCTGGAAAT	0.388000													8	19					0	0	0	0
PCNX	22990	broad.mit.edu	37	14	71493536	71493536	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:71493536C>T	uc001xmo.2	+	15	3849	c.3403C>T	c.(3403-3405)CAG>TAG	p.Q1135*	PCNX_uc010are.1_Nonsense_Mutation_p.Q1024*|PCNX_uc010arf.1_5'UTR	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1135						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCTCCTGCCTCAGGTGAATAC	0.284000													14	64					0	0	0	0
VSX2	338917	broad.mit.edu	37	14	74726405	74726405	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:74726405G>A	uc001xpq.2	+	4	770	c.680G>A	c.(679-681)CGG>CAG	p.R227Q		NM_182894	NP_878314	P58304	VSX2_HUMAN	visual system homeobox 2	227	CVC.		R -> W (in MCOP2).		multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00154)		GCCATGGTGCGGCACTCCATC	0.637000													12	56					0	0	0	0
TDP1	55775	broad.mit.edu	37	14	90433740	90433740	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:90433740C>T	uc001xxy.2	+	5	932	c.633C>T	c.(631-633)CTC>CTT	p.L211L	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Silent_p.L211L|TDP1_uc010atn.2_Silent_p.L211L|TDP1_uc001xya.2_5'UTR|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Silent_p.L211L	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	211					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGACTGGCTCGTAAAACAGT	0.408000								Repair_of_DNA-protein_crosslinks					18	81					0	0	0	0
KCNK13	56659	broad.mit.edu	37	14	90650902	90650902	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:90650902A>G	uc001xye.1	+	2	1224	c.782A>G	c.(781-783)AAC>AGC	p.N261S		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	261						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CGCTTTGCCAACTTCGTCTTC	0.493000													23	81					0	0	0	0
ATG2B	55102	broad.mit.edu	37	14	96783566	96783566	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:96783566G>A	uc001yfi.2	-	20	3491	c.3126C>T	c.(3124-3126)GAC>GAT	p.D1042D		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1042										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGTTCTGAGAGTCTAATTTTT	0.373000													12	60					0	0	0	0
MIR381	494330	broad.mit.edu	37	14	101512279	101512279	+	RNA	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:101512279T>C	hsa-mir-381|MI0000789	+			c.23T>C			uc010awd.2_RNA|MIR487B_hsa-mir-487b|MI0003530_5'Flank|MIR539_hsa-mir-539|MI0003514_5'Flank|MIR889_hsa-mir-889|MI0005540_5'Flank|MIR544_hsa-mir-544|MI0003515_5'Flank																	0						GGTTGCCCTTTGTATATTCGG	0.517000													3	13					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	106733134	106733134	+	Splice_Site	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:106733134A>G	uc010tyt.1	-	547		c.17600_splice	c.e547+1							Parts of antibodies, mostly variable regions.												0						GTGGGTTTTCACACTGTGTCT	0.498000													53	207					0	0	0	0
ADAM10	102	broad.mit.edu	37	15	58925416	58925416	+	Silent	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr15:58925416A>G	uc002afd.1	-	9	1599	c.1155T>C	c.(1153-1155)GTT>GTC	p.V385V	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Silent_p.V84V|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	385	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AGTTATGTCCAACTTCGTGAG	0.323000													13	29					0	0	0	0
MYO1E	4643	broad.mit.edu	37	15	59455404	59455404	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr15:59455404C>T	uc002aga.2	-	23	2951	c.2579G>A	c.(2578-2580)CGT>CAT	p.R860H		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	860					actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CTCCTCGTAACGCTTTGCTAA	0.433000													7	27					0	0	0	0
SRRM2	23524	broad.mit.edu	37	16	2816182	2816182	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:2816182C>T	uc002crk.2	+	11	6202	c.5653C>T	c.(5653-5655)CGA>TGA	p.R1885*	SRRM2_uc002crj.1_Nonsense_Mutation_p.R1789*|SRRM2_uc002crl.1_Nonsense_Mutation_p.R1885*|SRRM2_uc010bsu.1_Nonsense_Mutation_p.R1789*	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1885	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCTGATAAGCCGACGTAGGTC	0.592000													9	49					0	0	0	0
UBE2MP1	606551	broad.mit.edu	37	16	34404528	34404528	+	RNA	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:34404528G>A	uc002edv.1	-	1		c.235C>T				NR_002837				full-length cDNA clone CS0DH003YB23 of T cells (Jurkat cell line) of Homo sapiens (human).												0						CAGCTGCGCCGCCGACGCCTT	0.547000													10	34					0	0	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67318623	67318623	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:67318623C>T	uc002eso.3	+	12	4235	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M	PLEKHG4_uc002esp.3_Missense_Mutation_p.T374M|PLEKHG4_uc002esq.3_Missense_Mutation_p.T567M|PLEKHG4_uc010cef.2_Missense_Mutation_p.T567M|PLEKHG4_uc002ess.3_Missense_Mutation_p.T567M|PLEKHG4_uc010ceg.2_Missense_Mutation_p.T486M	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	567					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CAGGCCTTGACGTGGGCTGAG	0.448000													6	27					0	0	0	0
NFAT5	10725	broad.mit.edu	37	16	69703948	69703948	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:69703948G>A	uc002exm.1	+	7	2592	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	NFAT5_uc002exh.1_Missense_Mutation_p.E256K|NFAT5_uc002exi.2_Missense_Mutation_p.E386K|NFAT5_uc002exj.1_Missense_Mutation_p.E386K|NFAT5_uc002exk.1_Missense_Mutation_p.E386K|NFAT5_uc002exl.1_Missense_Mutation_p.E480K|NFAT5_uc002exn.1_Missense_Mutation_p.E480K	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	462					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGGAGAAGAAGAAGTGTTTTT	0.363000													8	38					0	0	0	0
LDHD	197257	broad.mit.edu	37	16	75146543	75146543	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:75146543C>T	uc002fdm.2	-	10	1362	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	LDHD_uc002fdn.2_Missense_Mutation_p.E416K	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	439							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						CCCAGTTCCTCGGCGTCATCA	0.602000													10	39					0	0	0	0
VMO1	284013	broad.mit.edu	37	17	4688867	4688867	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:4688867G>A	uc002fyx.2	-	3	481	c.399C>T	c.(397-399)CTC>CTT	p.L133L	VMO1_uc010vsh.1_3'UTR|VMO1_uc010vsi.1_3'UTR|VMO1_uc002fyy.2_3'UTR	NM_182566	NP_872372	Q7Z5L0	VMO1_HUMAN	vitelline membrane outer layer 1 isoform 1	133					vitelline membrane formation	extracellular region				ovary(1)	1						TGTTGTCACCGAGGGTCGTGG	0.642000													6	23					0	0	0	0
LRRC37B2	147172	broad.mit.edu	37	17	28961033	28961033	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:28961033T>G	uc002hfl.3	+	5	727	c.496T>G	c.(496-498)TAT>GAT	p.Y166D	LRRC37B2_uc010csj.1_Intron|LRRC37B2_uc010wbq.1_RNA|LRRC37B2_uc010csi.2_RNA					RecName: Full=Putative LRRC37B-like protein 2;												0						AGTTCCAGGATATGACTATAA	0.249000													3	34					0	0	0	0
CCT6B	10693	broad.mit.edu	37	17	33288392	33288392	+	Silent	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:33288392G>C	uc002hig.2	-	1	115	c.21C>G	c.(19-21)GTC>GTG	p.V7V	CCT6B_uc010ctg.2_Silent_p.V7V|CCT6B_uc010wcc.1_Silent_p.V7V|ZNF830_uc002hih.3_5'Flank	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	7					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				CCTTGGAGTTGACGGCCTTTA	0.572000													4	48					0	0	0	0
C17orf66	256957	broad.mit.edu	37	17	34190080	34190080	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:34190080C>G	uc002hke.1	-	8	824	c.675G>C	c.(673-675)GAG>GAC	p.E225D	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.E185D|C17orf66_uc010wcm.1_Missense_Mutation_p.E191D	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	225							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCTCATTTTTCTCCTTCAGCT	0.537000													20	104					0	0	0	0
ABCC3	8714	broad.mit.edu	37	17	48750428	48750428	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:48750428G>A	uc002isl.2	+	18	2418	c.2338G>A	c.(2338-2340)GCG>ACG	p.A780T		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	780	ABC transporter 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCACTGTCCGCGGTGGACTC	0.602000													13	46					0	0	0	0
TEX2	55852	broad.mit.edu	37	17	62238187	62238187	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:62238187C>T	uc002jec.2	-	8	2951	c.2778G>A	c.(2776-2778)CTG>CTA	p.L926L	TEX2_uc002jed.2_Silent_p.L933L|TEX2_uc002jee.2_Silent_p.L926L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	926					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTCCAACCTTCAGGGCTTCAA	0.443000													54	213					0	0	0	0
LOC727896	727896	broad.mit.edu	37	18	2946226	2946226	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr18:2946226G>A	uc010wyu.1	-	1	396	c.309C>T	c.(307-309)GAC>GAT	p.D103D	LPIN2_uc002klo.2_Intron	NR_026659				Homo sapiens cDNA clone IMAGE:4614712, containing frame-shift errors.												0						TTTTTATCGCGTCTACTGTCT	0.393000													30	132					0	0	0	0
MC2R	4158	broad.mit.edu	37	18	13884716	13884716	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr18:13884716T>A	uc002ksp.1	-	2	979	c.802A>T	c.(802-804)AAT>TAT	p.N268Y		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	268	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	ATGACGGCATTGCACATGATC	0.502000													23	69					0	0	0	0
PQLC1	80148	broad.mit.edu	37	18	77664144	77664144	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr18:77664144G>C	uc002lnl.2	-	6	820	c.648C>G	c.(646-648)TTC>TTG	p.F216L	PQLC1_uc010dre.2_Missense_Mutation_p.F133L|PQLC1_uc002lnk.2_Missense_Mutation_p.F198L|PQLC1_uc010xfm.1_Nonsense_Mutation_p.S126*	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	216	PQ-loop 2.					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		AGGCCGTCTTGAAGGCGTCAC	0.647000													14	20					0	0	0	0
CHAF1A	10036	broad.mit.edu	37	19	4431980	4431980	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:4431980G>A	uc002mal.2	+	12	2079	c.1979G>A	c.(1978-1980)CGC>CAC	p.R660H		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	660	Necessary for homodimerization and competence for chromatin assembly.|Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CATAAGGTCCGCCAGAAACTG	0.562000								Chromatin_Structure					4	112					0	0	0	0
ISYNA1	51477	broad.mit.edu	37	19	18546719	18546719	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:18546719C>T	uc002njd.1	-	8	1038	c.988G>A	c.(988-990)GTG>ATG	p.V330M	ISYNA1_uc002nja.1_Missense_Mutation_p.V202M|ISYNA1_uc002njb.1_Missense_Mutation_p.V248M|ISYNA1_uc002njc.1_Missense_Mutation_p.V180M|ISYNA1_uc010xqh.1_Missense_Mutation_p.V128M|ISYNA1_uc002nje.1_Missense_Mutation_p.V276M|ISYNA1_uc002njf.1_Missense_Mutation_p.V180M	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	330					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						TTGTAACTCACGATGGACATG	0.622000													40	160					0	0	0	0
AXL	558	broad.mit.edu	37	19	41765694	41765694	+	Missense_Mutation	SNP	C	T	T	rs61737385		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:41765694C>T	uc010ehj.2	+	20	2760	c.2570C>T	c.(2569-2571)GCG>GTG	p.A857V	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_5'Flank|HNRNPUL1_uc002oqa.3_5'Flank|AXL_uc010ehk.2_Missense_Mutation_p.A848V|HNRNPUL1_uc010ehl.1_5'Flank	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	857	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TGCCTCACTGCGGCTGAGGTC	0.637000													7	42					0	0	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46388584	46388584	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:46388584G>A	uc002pds.1	-	1	793	c.449C>T	c.(448-450)GCG>GTG	p.A150V		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		GGCCCTTCGCGCCCCCTCAGC	0.716000													6	16					0	0	0	0
KLK3	354	broad.mit.edu	37	19	51361366	51361366	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:51361366C>A	uc002pts.1	+	3	329	c.288C>A	c.(286-288)TTC>TTA	p.F96L	KLK3_uc010ycj.1_Missense_Mutation_p.F96L|KLK3_uc002ptr.1_Intron|KLK3_uc010eof.1_Intron	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	96	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GCCACAGCTTCCCACACCCGC	0.577000													13	41					1.49906e-05	1.52432e-05	1	0
ZNF320	162967	broad.mit.edu	37	19	53384034	53384034	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:53384034C>T	uc002qag.2	-	4	1536	c.1345G>A	c.(1345-1347)GCC>ACC	p.A449T	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.A395T|ZNF320_uc002qai.2_Missense_Mutation_p.A449T	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	449	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		GAATTAAAGGCTTTACCACAA	0.403000													6	65					0	0	0	0
KIR3DL3	115653	broad.mit.edu	37	19	55239242	55239242	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:55239242C>T	uc002qgu.1	+	4	539	c.521C>T	c.(520-522)GCG>GTG	p.A174V	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	174	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity	p.A174V(1)		ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CTCCACGATGCGGGTTCCCAG	0.547000													62	41					0	0	0	0
NLRP4	147945	broad.mit.edu	37	19	56369057	56369057	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:56369057C>G	uc002qmd.3	+	3	720	c.298C>G	c.(298-300)CAA>GAA	p.Q100E	NLRP4_uc002qmf.2_Missense_Mutation_p.Q25E|NLRP4_uc010etf.2_Translation_Start_Site	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	100							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAAGACCTATCAAGCTCACGC	0.423000													17	74					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57328787	57328787	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:57328787G>C	uc002qnu.2	-	7	1374	c.1023C>G	c.(1021-1023)TTC>TTG	p.F341L	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.F312L|PEG3_uc002qnv.2_Missense_Mutation_p.F341L|PEG3_uc002qnw.2_Missense_Mutation_p.F217L|PEG3_uc002qnx.2_Missense_Mutation_p.F215L|PEG3_uc010etr.2_Missense_Mutation_p.F341L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	341					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACATTCTGGGGAATCTCTGTG	0.473000													12	83					0	0	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967762	58967762	+	Missense_Mutation	SNP	C	T	T	rs143809080		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:58967762C>T	uc002qsv.1	+	4	1558	c.1451C>T	c.(1450-1452)ACG>ATG	p.T484M	ZNF324B_uc002qsu.1_Missense_Mutation_p.T474M|ZNF324B_uc010euq.1_Missense_Mutation_p.T484M	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	484	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TTCGTGTGCACGCAGTGTGGC	0.672000													11	62					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415898	15415898	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:15415898C>G	uc002rcc.1	-	44	5460	c.5434G>C	c.(5434-5436)GAA>CAA	p.E1812Q	NBAS_uc010exl.1_Missense_Mutation_p.E884Q|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1812										ovary(2)|liver(1)|skin(1)	4						TCCAATGCTTCAAGAGGACTC	0.373000													11	76					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	140992403	140992403	+	Silent	SNP	C	T	T	rs149169898	byFrequency	TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:140992403C>T	uc002tvj.1	-	90	14583	c.13611G>A	c.(13609-13611)GCG>GCA	p.A4537A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4537	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		agatgggcggcgctgtgtgtg	0.060000										TSP Lung(27;0.18)			7	46					0	0	0	0
MYO3B	140469	broad.mit.edu	37	2	171055792	171055792	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:171055792C>T	uc002ufy.2	+	2	220	c.77C>T	c.(76-78)ACC>ATC	p.T26I	MYO3B_uc002ufv.2_Missense_Mutation_p.T13I|MYO3B_uc010fqb.1_Missense_Mutation_p.T13I|MYO3B_uc002ufz.2_Missense_Mutation_p.T26I|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Missense_Mutation_p.T13I	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	26					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						CCCACAGACACCTGGGAAATT	0.413000													8	43					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179604387	179604387	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:179604387C>T	uc010zfh.1	-	46	13284	c.13060G>A	c.(13060-13062)GAA>AAA	p.E4354K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4287K|TTN_uc010zfj.1_Missense_Mutation_p.E4162K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	4280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTAGATTCAACTTCTGGT	0.398000													29	99					0	0	0	0
MAP2	4133	broad.mit.edu	37	2	210559886	210559886	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:210559886C>A	uc002vde.1	+	7	3240	c.2992C>A	c.(2992-2994)CAA>AAA	p.Q998K	MAP2_uc002vdc.1_Missense_Mutation_p.Q998K|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.Q994K	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	998					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AACCTATGAGCAAGCTTTGGC	0.418000													8	60					0.000157383	0.000159142	1	0
CPS1	1373	broad.mit.edu	37	2	211459299	211459299	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:211459299C>T	uc002vee.3	+	12	1364	c.1232C>T	c.(1231-1233)CCG>CTG	p.P411L	CPS1_uc010fur.2_Missense_Mutation_p.P417L|CPS1_uc010fus.2_5'UTR	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	411					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TCAGTCTTACCGAAGCCAGCA	0.363000													10	41					0	0	0	0
STK36	27148	broad.mit.edu	37	2	219559301	219559301	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:219559301C>T	uc002viu.2	+	21	2720	c.2454C>T	c.(2452-2454)GAC>GAT	p.D818D	STK36_uc002viv.2_Silent_p.D818D|STK36_uc002viw.2_5'UTR|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	818					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		TGACCTTTGACCTCCAGCCCA	0.552000													20	84					0	0	0	0
MSL3L2	151507	broad.mit.edu	37	2	234775835	234775835	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:234775835C>G	uc010znf.1	-	2	245	c.7G>C	c.(7-9)GAA>CAA	p.E3Q		NR_024322				SubName: Full=cDNA FLJ52683, highly similar to Male-specific lethal 3-like 1; SubName: Full=cDNA, FLJ79271, highly similar to Male-specific lethal 3-like 1; SubName: Full=HCG1642047;												0						ACTGTTCTTTCTTCCATTTCC	0.383000													4	32					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238277502	238277502	+	Missense_Mutation	SNP	C	T	T	rs115765346	by1000genomes	TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:238277502C>T	uc002vwl.2	-	10	4889	c.4604G>A	c.(4603-4605)CGC>CAC	p.R1535H	COL6A3_uc002vwo.2_Missense_Mutation_p.R1329H|COL6A3_uc010znj.1_Missense_Mutation_p.R928H	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1535	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTCTTCTATGCGACTCCCCGC	0.592000													11	65					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8719969	8719969	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr20:8719969T>C	uc002wnb.2	+	21	2273	c.2270T>C	c.(2269-2271)ATT>ACT	p.I757T	PLCB1_uc010zrb.1_Missense_Mutation_p.I656T|PLCB1_uc002wna.2_Missense_Mutation_p.I757T|PLCB1_uc002wnc.1_Missense_Mutation_p.I656T|PLCB1_uc002wnd.1_Missense_Mutation_p.I334T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	757	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGTAAATTCATTGGCCACCGT	0.418000													13	69					0	0	0	0
RNF160	26046	broad.mit.edu	37	21	30303556	30303556	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:30303556G>A	uc002ymr.2	-	29	5310	c.5297C>T	c.(5296-5298)TCA>TTA	p.S1766L		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1720	RING-type.						ligase activity|zinc ion binding				0						GTGAATGACTGAGAAACAGAT	0.363000													14	61					0	0	0	0
TMEM50B	757	broad.mit.edu	37	21	34823152	34823152	+	Silent	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:34823152A>G	uc002yrt.1	-	7	628	c.450T>C	c.(448-450)TTT>TTC	p.F150F	TMEM50B_uc002yrs.1_RNA|TMEM50B_uc010gmb.1_RNA	NM_006134	NP_006125	P56557	TM50B_HUMAN	transmembrane protein 50B	150						endoplasmic reticulum|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CGGTTCTTCCAAATTTGTAGA	0.348000													13	40					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41725414	41725414	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:41725414C>T	uc002yyq.1	-	5	1364	c.912G>A	c.(910-912)GTG>GTA	p.V304V	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	304	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCGGCCTATCACCTTAGCAG	0.502000													28	152					0	0	0	0
PRDM15	63977	broad.mit.edu	37	21	43221624	43221624	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:43221624C>A	uc002yzq.1	-	31	4411	c.4300G>T	c.(4300-4302)GAA>TAA	p.E1434*	PRDM15_uc002yzo.2_Nonsense_Mutation_p.E1105*|PRDM15_uc002yzp.2_Nonsense_Mutation_p.E1125*|PRDM15_uc002yzr.1_Nonsense_Mutation_p.E1125*	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCGAGGCTTCCGGCTGGGGG	0.587000													12	53					2.32078e-09	2.41415e-09	1	0
NIPSNAP1	8508	broad.mit.edu	37	22	29966459	29966459	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:29966459G>A	uc003afx.3	-	2	234	c.161C>T	c.(160-162)CCC>CTC	p.P54L	NIPSNAP1_uc011akp.1_Missense_Mutation_p.P34L	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1	54								p.?(1)		skin(1)	1						ATCCTTCCGGGGATCCACTTT	0.542000													5	24					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41531855	41531855	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:41531855C>T	uc003azl.3	+	7	1962	c.1567C>T	c.(1567-1569)CAA>TAA	p.Q523*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	523					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGTAGGAGTTCAAACGCCGAG	0.373000			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				12	46					0	0	0	0
SCUBE1	80274	broad.mit.edu	37	22	43610219	43610219	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:43610219C>T	uc003bdt.1	-	16	2018	c.1930G>A	c.(1930-1932)GGC>AGC	p.G644S		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	644					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				ACACACTGGCCGAGCTCACCA	0.642000													3	48					0	0	0	0
NISCH	11188	broad.mit.edu	37	3	52521429	52521429	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:52521429G>A	uc011beg.1	+	17	1993	c.1921G>A	c.(1921-1923)GAG>AAG	p.E641K	NISCH_uc003ded.3_Missense_Mutation_p.E641K|NISCH_uc003dee.3_Missense_Mutation_p.E130K|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	641	Necessary for homooligomerization and targeting to endosomes.|Potential.|Glu-rich.|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ggaggaggatgaggaggagga	0.428000													12	23					0	0	0	0
ZBTB11	27107	broad.mit.edu	37	3	101370392	101370392	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:101370392C>A	uc003dve.3	-	11	3010	c.2780G>T	c.(2779-2781)CGA>CTA	p.R927L		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	927	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACGGAGTGTTCGAGCATCTAT	0.448000													28	114					2.48779e-11	2.61797e-11	1	0
C3orf30	152405	broad.mit.edu	37	3	118865322	118865322	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:118865322G>A	uc003ecb.1	+	1	326	c.286G>A	c.(286-288)GAT>AAT	p.D96N	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.D96N	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	96										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		CAACCCTGCTGATGTTTCTGA	0.473000													5	31					0	0	0	0
SLC15A2	6565	broad.mit.edu	37	3	121649690	121649690	+	Silent	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:121649690T>C	uc003eep.2	+	18	1710	c.1557T>C	c.(1555-1557)TTT>TTC	p.F519F	SLC15A2_uc011bjn.1_Silent_p.F488F	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	519					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CCCTCAGGTTTGTTAACACTT	0.289000													10	45					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126730864	126730864	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:126730864A>C	uc003ejg.2	+	9	2111	c.2107A>C	c.(2107-2109)ACC>CCC	p.T703P		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	726	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		AAAACCCATCACCCTGGCCGC	0.652000													6	26					0	0	0	0
PIK3CB	5291	broad.mit.edu	37	3	138417818	138417818	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:138417818C>G	uc011bmq.1	-	11	1701	c.1701G>C	c.(1699-1701)GAG>GAC	p.E567D	PIK3CB_uc011bmn.1_Missense_Mutation_p.E79D|PIK3CB_uc011bmo.1_Missense_Mutation_p.E13D|PIK3CB_uc011bmp.1_Missense_Mutation_p.E154D	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	567	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GTGGGAAAATCTCTCGGCAGT	0.378000													21	104					0	0	0	0
XRN1	54464	broad.mit.edu	37	3	142137436	142137436	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:142137436T>C	uc003eus.2	-	12	1323	c.1256A>G	c.(1255-1257)GAG>GGG	p.E419G	XRN1_uc003eut.2_Missense_Mutation_p.E419G|XRN1_uc003euu.2_Missense_Mutation_p.E419G|XRN1_uc003euv.1_Missense_Mutation_p.E280G|XRN1_uc003euw.2_Missense_Mutation_p.E419G|XRN1_uc011bnh.1_Missense_Mutation_p.E209G	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	419					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATCTTCAGTCTCATCTTCTAA	0.333000													7	32					0	0	0	0
SI	6476	broad.mit.edu	37	3	164750459	164750459	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:164750459T>C	uc003fei.2	-	24	2649	c.2587A>G	c.(2587-2589)ACA>GCA	p.T863A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	863	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATGAATGTGTGCACACAATA	0.333000										HNSCC(35;0.089)			6	64					0	0	0	0
SERPINI1	5274	broad.mit.edu	37	3	167543055	167543055	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:167543055C>T	uc003ffa.3	+	9	1375	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	SERPINI1_uc003ffb.3_Nonsense_Mutation_p.R393*	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	393					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						ATTCATGGGACGAGTCATGCA	0.318000													44	516					0	0	0	0
TNIK	23043	broad.mit.edu	37	3	170800121	170800121	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:170800121T>C	uc003fhh.2	-	27	3577	c.3232A>G	c.(3232-3234)AAA>GAA	p.K1078E	TNIK_uc003fhi.2_Missense_Mutation_p.K1023E|TNIK_uc003fhj.2_Missense_Mutation_p.K1049E|TNIK_uc003fhk.2_Missense_Mutation_p.K1070E|TNIK_uc003fhl.2_Missense_Mutation_p.K994E|TNIK_uc003fhm.2_Missense_Mutation_p.K1015E|TNIK_uc003fhn.2_Missense_Mutation_p.K1041E|TNIK_uc003fho.2_Missense_Mutation_p.K986E|TNIK_uc003fhg.2_Missense_Mutation_p.K256E|TNIK_uc003fhp.2_Missense_Mutation_p.K10E	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1078	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTATAGACTTTGCCTTGCCCA	0.438000													5	195					0	0	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176769363	176769363	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:176769363C>T	uc003fiw.3	-	5	616	c.356G>A	c.(355-357)AGC>AAC	p.S119N	TBL1XR1_uc003fix.3_Missense_Mutation_p.S119N|TBL1XR1_uc011bpz.1_5'UTR|TBL1XR1_uc003fiy.2_Missense_Mutation_p.S119N	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	119					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TCCTTGTTGGCTGGCTGCAGC	0.453000													13	290					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			73	123					0	0	0	0
MFN1	55669	broad.mit.edu	37	3	179069808	179069808	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:179069808T>C	uc003fjs.2	+	3	359	c.233T>C	c.(232-234)GTG>GCG	p.V78A	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.V106A	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	78	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CACATGAAGGTGGCATTTTTT	0.378000													67	368					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166024	193166024	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:193166024G>C	uc003ftd.2	-	18	2231	c.2123C>G	c.(2122-2124)TCA>TGA	p.S708*	ATP13A4_uc003fte.1_Nonsense_Mutation_p.S708*|ATP13A4_uc011bsr.1_Nonsense_Mutation_p.S179*|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	708	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TATCCGGGCTGAGATGAGCTC	0.393000													12	176					0	0	0	0
BDH1	622	broad.mit.edu	37	3	197241274	197241274	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:197241274G>A	uc003fxr.2	-	7	825	c.423C>T	c.(421-423)CTC>CTT	p.L141L	BDH1_uc003fxs.2_Silent_p.L141L|BDH1_uc003fxt.2_Silent_p.L54L|BDH1_uc003fxu.2_Silent_p.L141L	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	141					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CATTGTTAACGAGGCCCCACA	0.587000													13	211					0	0	0	0
FAM193A	8603	broad.mit.edu	37	4	2661312	2661312	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:2661312G>A	uc010icl.2	+	7	895	c.544G>A	c.(544-546)GAG>AAG	p.E182K	FAM193A_uc010ick.2_Missense_Mutation_p.E382K|FAM193A_uc003gfd.2_Missense_Mutation_p.E182K|FAM193A_uc011bvm.1_Missense_Mutation_p.E206K|FAM193A_uc011bvn.1_Missense_Mutation_p.E182K|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.E36K	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	182										ovary(3)	3						AGTTACTGGCGAGAACAACTT	0.453000													9	39					0	0	0	0
KCTD8	386617	broad.mit.edu	37	4	44449818	44449818	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:44449818G>A	uc003gwu.2	-	1	1007	c.723C>T	c.(721-723)ATC>ATT	p.I241I		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	241						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TGGCCAGCGCGATGCGCCCGC	0.667000										HNSCC(17;0.042)			4	12					0	0	0	0
SMAD1	4086	broad.mit.edu	37	4	146467854	146467854	+	Splice_Site	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:146467854G>A	uc003ikc.2	+	5	1192	c.776_splice	c.e5-1	p.D259_splice	SMAD1_uc003ikd.2_Splice_Site_p.D259_splice|SMAD1_uc010iov.2_Splice_Site_p.D259_splice|SMAD1_uc011cic.1_Splice_Site_p.D220_splice	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1						BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					CTTTCCTCTAGATGTTCAGGC	0.448000													40	103					0	0	0	0
POC5	134359	broad.mit.edu	37	5	74981280	74981280	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:74981280C>G	uc003keh.3	-	10	1356	c.1159G>C	c.(1159-1161)GAG>CAG	p.E387Q	POC5_uc010izu.2_Missense_Mutation_p.E270Q|POC5_uc003keg.3_Missense_Mutation_p.E362Q	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	387					cell cycle	centriole				lung(1)	1						GGACCATACTCTTCCTTTTTA	0.398000													17	139					0	0	0	0
CTNNA1	1495	broad.mit.edu	37	5	138145823	138145823	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:138145823C>G	uc003ldh.2	+	4	493	c.398C>G	c.(397-399)TCT>TGT	p.S133C	CTNNA1_uc011cyx.1_Missense_Mutation_p.S30C|CTNNA1_uc011cyy.1_Missense_Mutation_p.S10C|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Missense_Mutation_p.S133C	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	133	Interaction with JUP and CTNNB1.|Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GCTTTGCTCTCTGCTGTTACC	0.478000													28	62					0	0	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139918552	139918552	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:139918552C>T	uc003lfs.1	+	33	7577	c.7453C>T	c.(7453-7455)CAG>TAG	p.Q2485*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.Q2485*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.Q1241*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.Q1140*|ANKHD1_uc010jfl.2_Nonsense_Mutation_p.Q861*|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.Q630*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2485						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCATCCTCAGCTTGCTGA	0.363000													20	75					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165875	140165875	+	5'Flank	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140165875A>G	uc003lhb.2	+						PCDHA1_uc003lha.2_5'Flank|PCDHA1_uc003lgz.2_5'Flank	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor						homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTTTTGCAATGGTGTTTT	0.483000													29	150					0	0	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710925	140710925	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140710925C>T	uc003lji.1	+	1	674	c.674C>T	c.(673-675)ACC>ATC	p.T225I	PCDHGA1_uc011dan.1_Missense_Mutation_p.T225I	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	225	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCAGGGACCCTCAGAATT	0.507000													16	49					0	0	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140782613	140782613	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140782613C>T	uc003lkh.1	+	1	94	c.94C>T	c.(94-96)CGC>TGC	p.R32C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.R32C	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	32	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTCAGATTCGCTACTCAGT	0.602000													14	69					0	0	0	0
DIAPH1	1729	broad.mit.edu	37	5	140903714	140903714	+	Silent	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140903714A>G	uc003llb.3	-	28	3798	c.3657T>C	c.(3655-3657)CGT>CGC	p.R1219R	DIAPH1_uc011dbd.1_Silent_p.R113R|DIAPH1_uc003llc.3_Silent_p.R1210R	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	1219	DAD.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTTACCTTGACGGGGCCCTC	0.532000													14	65					0	0	0	0
PCDH1	5097	broad.mit.edu	37	5	141248480	141248480	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:141248480A>C	uc003llq.2	-	2	674	c.557T>G	c.(556-558)CTC>CGC	p.L186R	PCDH1_uc003llp.2_Missense_Mutation_p.L186R|PCDH1_uc011dbf.1_Missense_Mutation_p.L164R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	186	Extracellular (Potential).|Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GATGGGGAAGAGTGAGCCGAT	0.572000													46	204					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153149822	153149822	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:153149822G>A	uc003lva.3	+	13	2482	c.2117G>A	c.(2116-2118)CGA>CAA	p.R706Q	GRIA1_uc003luy.3_Missense_Mutation_p.R706Q|GRIA1_uc003luz.3_Missense_Mutation_p.R611Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R626Q|GRIA1_uc011dcx.1_Missense_Mutation_p.R637Q|GRIA1_uc011dcy.1_Missense_Mutation_p.R716Q|GRIA1_uc011dcz.1_Missense_Mutation_p.R716Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	706	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGGATGATTCGAGTGAGGAAA	0.483000													14	47					0	0	0	0
RPP40	10799	broad.mit.edu	37	6	4998960	4998960	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:4998960C>T	uc003mwl.2	-	5	584	c.549G>A	c.(547-549)TGG>TGA	p.W183*	RPP40_uc003mwm.2_Nonsense_Mutation_p.W160*	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	183					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				CTGTTTTATGCCAAGCCAAAA	0.299000													4	21					0	0	0	0
FARS2	10667	broad.mit.edu	37	6	5369231	5369231	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:5369231A>G	uc010jnv.1	+	2	764	c.428A>G	c.(427-429)AAC>AGC	p.N143S	FARS2_uc003mwr.2_Missense_Mutation_p.N143S|FARS2_uc003mws.1_Missense_Mutation_p.N143S	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	143					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	AAGGGGGACAACTATTACCTG	0.567000													10	74					0	0	0	0
RREB1	6239	broad.mit.edu	37	6	7229769	7229769	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:7229769G>A	uc003mxc.2	+	10	1827	c.1437G>A	c.(1435-1437)TCG>TCA	p.S479S	RREB1_uc003mxb.2_Silent_p.S479S|RREB1_uc010jnx.2_Silent_p.S479S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	479					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGGCAGCCTCGGCTCCCCCTC	0.607000													26	208					0	0	0	0
MAK	4117	broad.mit.edu	37	6	10770373	10770373	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:10770373T>C	uc003mzl.2	-	12	1917	c.1688A>G	c.(1687-1689)CAC>CGC	p.H563R	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_RNA|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.H563R	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	563					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				AGGTGCTAAGTGGATCCTCTG	0.398000													17	90					0	0	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333678	33333678	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:33333678G>A	uc003shx.2	-	1	462	c.328C>T	c.(328-330)CAA>TAA	p.Q110*		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						AGGATGATTTGATTGGCAGGG	0.582000													18	95					0	0	0	0
MLN	4295	broad.mit.edu	37	6	33768873	33768873	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:33768873G>A	uc003off.1	-	2	139	c.68C>T	c.(67-69)ACG>ATG	p.T23M	MLN_uc003ofg.1_Missense_Mutation_p.T23M|MLN_uc011drn.1_Missense_Mutation_p.T23M	NM_002418	NP_002409	P12872	MOTI_HUMAN	motilin isoform 1 preproprotein	23					cell-cell signaling|G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	hormone activity				0						GAAGGCTTCCGTCTGGGAGGC	0.577000													18	102					0	0	0	0
KIF6	221458	broad.mit.edu	37	6	39513399	39513399	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:39513399G>A	uc003oot.2	-	11	1342	c.1247C>T	c.(1246-1248)GCG>GTG	p.A416V	KIF6_uc010jxa.1_Missense_Mutation_p.A207V|KIF6_uc011dua.1_Missense_Mutation_p.A416V|KIF6_uc010jxb.1_Missense_Mutation_p.A416V	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	416					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						ACGCATATCCGCGCCAACCTC	0.363000													7	83					0	0	0	0
LRFN2	57497	broad.mit.edu	37	6	40360590	40360590	+	Missense_Mutation	SNP	C	T	T	rs55706368		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:40360590C>T	uc003oph.1	-	3	1927	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	488	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACACACAAGTCGTAGCCAGTC	0.597000													4	27					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31692184	31692184	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:31692184A>G	uc003tcj.1	+	14	3869	c.2876A>G	c.(2875-2877)CAA>CGA	p.Q959R	CCDC129_uc011kad.1_Missense_Mutation_p.Q969R|CCDC129_uc003tci.1_Missense_Mutation_p.Q810R|CCDC129_uc011kae.1_Missense_Mutation_p.Q985R|CCDC129_uc003tck.1_Missense_Mutation_p.Q867R	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	959											0						AATCTGCATCAATATAACTGG	0.468000													3	16					0	0	0	0
Unknown	0	broad.mit.edu	37	7	102136619	102136619	+	5'Flank	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:102136619G>C	uc011kkt.1	-						uc003uzs.1_5'Flank|uc010lia.1_Missense_Mutation_p.L275V|uc003uzt.1_Missense_Mutation_p.L347V|uc003uzu.1_Missense_Mutation_p.L347V|POLR2J3_uc011kku.1_Missense_Mutation_p.L275V|uc003uzv.1_5'Flank|uc010lib.1_Missense_Mutation_p.L155V					SubName: Full=cDNA FLJ50902, moderately similar to Ras GTPase-activating protein 4;																		TTTGAGGCCAGAGAGTTGCTC	0.408000													18	240					0	0	0	0
NRF1	4899	broad.mit.edu	37	7	129367082	129367082	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:129367082G>A	uc003voz.2	+	10	1342	c.1225G>A	c.(1225-1227)GAA>AAA	p.E409K	NRF1_uc003vpa.2_Missense_Mutation_p.E409K|NRF1_uc011kpa.1_Missense_Mutation_p.E248K|NRF1_uc003vpb.2_Missense_Mutation_p.E409K	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	409	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TGCCCGCAGCGAAGCTGCCGC	0.577000													5	38					0	0	0	0
FLJ10661	286042	broad.mit.edu	37	8	8095858	8095858	+	RNA	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:8095858G>A	uc011kwt.1	+	8		c.1053G>A			FLJ10661_uc010lrq.2_Intron|FLJ10661_uc003wsf.3_Intron	NR_024362				Homo sapiens cDNA FLJ60033 complete cds, highly similar to Protein FAM86A.												0						CCATGGACCCGTCTCTGTCCC	0.602000													7	35					0	0	0	0
POLR3D	661	broad.mit.edu	37	8	22106636	22106636	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:22106636C>T	uc003xbl.2	+	7	818	c.735C>T	c.(733-735)CTC>CTT	p.L245L	POLR3D_uc003xbm.2_Silent_p.L245L|POLR3D_uc011kze.1_Intron	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	245					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTCCAGGCCTCCCGAAGGATG	0.592000													4	39					0	0	0	0
ADAM32	203102	broad.mit.edu	37	8	39022696	39022696	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:39022696G>A	uc003xmt.3	+	9	1059	c.814G>A	c.(814-816)GAT>AAT	p.D272N	ADAM32_uc011lch.1_Missense_Mutation_p.D279N|ADAM32_uc003xmu.3_Missense_Mutation_p.D272N	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	272	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			AAGGCCTCATGATATTGCATA	0.289000													5	27					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55542592	55542592	+	Silent	SNP	T	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:55542592T>C	uc003xsd.1	+	4	6298	c.6150T>C	c.(6148-6150)AAT>AAC	p.N2050N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2050					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGGATTCAAATACACAAGACC	0.338000													6	46					0	0	0	0
MMP16	4325	broad.mit.edu	37	8	89180146	89180146	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:89180146C>T	uc003yeb.3	-	4	743	c.461G>A	c.(460-462)CGT>CAT	p.R154H	MMP16_uc003yec.2_Missense_Mutation_p.R154H	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	154	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						ATCAAAGGCACGGCGAATAGC	0.368000													7	46					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110456922	110456922	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:110456922A>T	uc003yne.2	+	38	4928	c.4824A>T	c.(4822-4824)GAA>GAT	p.E1608D		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1608	Extracellular (Potential).|IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGTCGTAGAAGAAAGTAGTG	0.358000										HNSCC(38;0.096)			81	210					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113960032	113960032	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:113960032C>T	uc003ynu.2	-	9	1654	c.1495G>A	c.(1495-1497)GGA>AGA	p.G499R	CSMD3_uc003ynt.2_Missense_Mutation_p.G459R|CSMD3_uc011lhx.1_Missense_Mutation_p.G395R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	499	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATCTGATCCGATTCTCTTC	0.294000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	60					0	0	0	0
DENND3	22898	broad.mit.edu	37	8	142178285	142178285	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:142178285G>A	uc003yvy.2	+	13	1974	c.1696G>A	c.(1696-1698)GTT>ATT	p.V566I	DENND3_uc010mep.2_Missense_Mutation_p.V527I|DENND3_uc003yvz.1_Missense_Mutation_p.V250I	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	566										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCGAGGGCTCGTTTATCTGAT	0.522000													14	152					0	0	0	0
C9orf135	138255	broad.mit.edu	37	9	72521027	72521027	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:72521027C>T	uc004ahl.2	+	6	730	c.665C>T	c.(664-666)ACT>ATT	p.T222I	C9orf135_uc011lrw.1_3'UTR|C9orf135_uc010moq.2_Missense_Mutation_p.T114I|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_3'UTR	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	222	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TATCCCTTGACTAGTGGGCCT	0.338000													12	64					0	0	0	0
SLC44A1	23446	broad.mit.edu	37	9	108151336	108151336	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:108151336G>C	uc004bcn.2	+	16	2194	c.1973G>C	c.(1972-1974)TGA>TCA	p.*658S	SLC44A1_uc010mtk.1_Intron|SLC44A1_uc004bco.1_Intron	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	658						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	AGTTCTGCTTGAACCTAGCCG	0.279000													33	149					0	0	0	0
RGS3	5998	broad.mit.edu	37	9	116353615	116353615	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:116353615G>T	uc004bhq.2	+	22	3227	c.3018G>T	c.(3016-3018)ATG>ATT	p.M1006I	RGS3_uc004bhs.2_Missense_Mutation_p.M896I|RGS3_uc004bht.2_Missense_Mutation_p.M725I|RGS3_uc010muy.2_Missense_Mutation_p.M399I|RGS3_uc004bhv.2_Missense_Mutation_p.M327I|RGS3_uc010muz.1_Missense_Mutation_p.M345I|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.M316I|RGS3_uc004bhx.2_Missense_Mutation_p.M327I|RGS3_uc004bhy.1_Missense_Mutation_p.M316I|RGS3_uc004bhz.2_Missense_Mutation_p.M348I|RGS3_uc004bia.2_5'Flank	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1006					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CTCCGCAGATGAGCGGGGCTG	0.572000													8	52					3.09899e-07	3.20524e-07	1	0
OR1J4	26219	broad.mit.edu	37	9	125282179	125282179	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:125282179A>G	uc011lyw.1	+	1	760	c.760A>G	c.(760-762)ACA>GCA	p.T254A		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATTATGGCACAATTATTGG	0.493000													16	70					0	0	0	0
C9orf167	54863	broad.mit.edu	37	9	140174030	140174030	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:140174030G>A	uc004cmn.2	+	2	1006	c.889G>A	c.(889-891)GTG>ATG	p.V297M	C9orf167_uc011mew.1_5'Flank	NM_017723	NP_060193	Q9NXH8	CI167_HUMAN	hypothetical protein LOC54863	297					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity			pancreas(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000728)		CGCCATCTACGTGCTCCTCAG	0.716000													3	13					0	0	0	0
EHMT1	79813	broad.mit.edu	37	9	140657192	140657192	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:140657192C>T	uc011mfc.1	+	10	1604	c.1567C>T	c.(1567-1569)CGG>TGG	p.R523W	EHMT1_uc004coa.2_Missense_Mutation_p.R523W|EHMT1_uc004cob.1_Missense_Mutation_p.R492W|FLJ40292_uc010nco.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	523					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTGCAGCTGCCGGATGGAAAC	0.537000													8	36					0	0	0	0
SMC1A	8243	broad.mit.edu	37	X	53426517	53426517	+	Silent	SNP	G	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:53426517G>A	uc004dsg.2	-	16	2625	c.2556C>T	c.(2554-2556)CTC>CTT	p.L852L	SMC1A_uc011moe.1_Silent_p.L830L	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	852	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						TTACCTTTTTGAGCTTTTCTA	0.333000													13	28					0	0	0	0
WDR44	54521	broad.mit.edu	37	X	117527109	117527109	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:117527109C>T	uc004eqn.2	+	4	1126	c.701C>T	c.(700-702)GCA>GTA	p.A234V	WDR44_uc004eqo.2_Missense_Mutation_p.A234V|WDR44_uc011mtr.1_Missense_Mutation_p.A209V|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	234	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CCTGTTCCAGCACGCCCACCT	0.517000													80	68					0	0	0	0
AIFM1	9131	broad.mit.edu	37	X	129272623	129272623	+	Silent	SNP	C	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:129272623C>T	uc004evg.2	-	9	1090	c.912G>A	c.(910-912)ACG>ACA	p.T304T	AIFM1_uc011mur.1_5'Flank|AIFM1_uc011mus.1_Silent_p.T304T|AIFM1_uc004evh.2_Silent_p.T300T|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	304	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						CACCGATAATCGTAATTGATT	0.433000													51	35					0	0	0	0
Unknown	0	broad.mit.edu	37	1	148903620	148903620	+	IGR	DEL	G	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:148903620delG								NBPF16 (145309 upstream) : LOC645166 (24666 downstream)																							GGGACCGGGAGGTGGACAACG	0.557													---	---	---							
Unknown	0	broad.mit.edu	37	10	74765963	74765964	+	IGR	INS	-	A	A			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:74765963_74765964insA								PLA2G12B (51453 upstream) : P4HA1 (1018 downstream)																							AGGACTTTGTTaaaaaaaaaaa	0.361													---	---	---							
ARHGAP20	57569	broad.mit.edu	37	11	110450902	110450902	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:110450902delA	uc001pkz.1	-	16	3053	c.2768delT	c.(2767-2769)TTAfs	p.L923fs	ARHGAP20_uc001pky.1_Frame_Shift_Del_p.L900fs|ARHGAP20_uc009yyb.1_Frame_Shift_Del_p.L887fs|ARHGAP20_uc001pla.1_Frame_Shift_Del_p.L887fs|ARHGAP20_uc001plb.2_Frame_Shift_Del_p.L466fs	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	923					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCTTGGGGGTAAAACCTTCTC	0.493													---	---	---							
Unknown	0	broad.mit.edu	37	12	9391909	9391909	+	5'Flank	DEL	T	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:9391909delT	uc001qvm.1	+											Homo sapiens cDNA FLJ44260 fis, clone TLIVE2000979.																		tttttttttcttttttttttt	0.249													---	---	---							
Unknown	0	broad.mit.edu	37	15	84858138	84858139	+	IGR	INS	-	T	T	rs71453232		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr15:84858138_84858139insT								ADAMTSL3 (149547 upstream) : LOC388152 (9461 downstream)																							TGGGGAGCTGGTGCAGAGGCCT	0.599													---	---	---							
Unknown	0	broad.mit.edu	37	2	91902877	91902878	+	IGR	DEL	AT	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:91902877_91902878delAT								LOC654342 (54902 upstream) : GGT8P (60490 downstream)																							AAATGCAAACATATGGAAATTT	0.317													---	---	---							
MAP3K13	9175	broad.mit.edu	37	3	185190964	185190964	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:185190964delA	uc010hyf.2	+	12	2111	c.1845delA	c.(1843-1845)TCAfs	p.S615fs	MAP3K13_uc011brt.1_Frame_Shift_Del_p.S408fs|MAP3K13_uc011bru.1_Frame_Shift_Del_p.S471fs|MAP3K13_uc003fpi.2_Frame_Shift_Del_p.S615fs|MAP3K13_uc010hyg.2_Frame_Shift_Del_p.S305fs	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	615					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGGAAAATTCACCCCATCCCA	0.532													---	---	---							
C3orf59	151963	broad.mit.edu	37	3	192517004	192517004	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:192517004delT	uc011bsp.1	-	2	968	c.647delA	c.(646-648)AATfs	p.N216fs		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	216											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		GATGGTCCCATTTTTTTCCAC	0.463													---	---	---							
C6orf89	221477	broad.mit.edu	37	6	36882411	36882411	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:36882411delT	uc003omx.2	+	6	921	c.637delT	c.(637-639)TTTfs	p.F213fs	C6orf89_uc003omv.2_Frame_Shift_Del_p.F107fs|C6orf89_uc003omw.2_Frame_Shift_Del_p.F220fs|C6orf89_uc011dtr.1_Frame_Shift_Del_p.F107fs|C6orf89_uc003omy.2_Frame_Shift_Del_p.F47fs	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	213						integral to membrane				ovary(1)	1						CTCTGAAGGGTTTTTCGCCAA	0.448													---	---	---							
MDN1	23195	broad.mit.edu	37	6	90426527	90426528	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:90426527_90426528delCT	uc003pnn.1	-	44	6700_6701	c.6584_6585delAG	c.(6583-6585)GAGfs	p.E2195fs		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2195					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTTGGCAAACTCTGAAATGTC	0.421													---	---	---							
Unknown	0	broad.mit.edu	37	7	2292427	2292429	+	IGR	DEL	CTC	-	-			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:2292427_2292429delCTC								NUDT1 (1647 upstream) : SNX8 (2212 downstream)																							cttacccgttctcctgctccctc	0.000													---	---	---							
GAGE10	643832	broad.mit.edu	37	X	49158061	49158062	+	5'Flank	INS	-	T	T			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:49158061_49158062insT	uc010nir.1	+							NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10												0	Ovarian(276;0.236)					gacatcattccttttttttttt	0.000													---	---	---							
