Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PLEKHG5	57449	broad.mit.edu	37	1	6534542	6534542	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:6534542G>A	uc001ano.1	-	7	677	c.576C>T	c.(574-576)TAC>TAT	p.Y192Y	PLEKHG5_uc001ann.1_Silent_p.Y173Y|PLEKHG5_uc001anq.1_Silent_p.Y213Y|PLEKHG5_uc001anp.1_Silent_p.Y213Y|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Silent_p.Y205Y|PLEKHG5_uc001ank.1_Silent_p.Y136Y|PLEKHG5_uc009vmb.1_Silent_p.Y136Y|PLEKHG5_uc001anl.1_Silent_p.Y136Y|PLEKHG5_uc001anm.1_Silent_p.Y136Y	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	192					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCCCGAACCTGTAGGCCTCGA	0.607													6	29					0	0	0	0
NOL9	79707	broad.mit.edu	37	1	6609717	6609717	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:6609717A>G	uc001ans.2	-	3	677	c.658T>C	c.(658-660)TCC>CCC	p.S220P	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	220					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		AACACAATGGAACACTGAGGA	0.413													7	71					0	0	0	0
CELA2A	63036	broad.mit.edu	37	1	15789236	15789236	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:15789236G>C	uc001awk.2	+	4	262	c.236G>C	c.(235-237)AGG>ACG	p.R79T		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGCTCCTCCAGGACCTACCGC	0.617													29	59					0	0	0	0
HSPG2	3339	broad.mit.edu	37	1	22172685	22172685	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:22172685G>A	uc001bfj.2	-	64	8420	c.8380C>T	c.(8380-8382)CGG>TGG	p.R2794W	HSPG2_uc009vqd.2_Missense_Mutation_p.R2795W	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2794	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCCATCACCCGGCACACGTAT	0.657													15	29					0	0	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930414	53930414	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:53930414G>A	uc001cvq.1	+	3	910	c.855G>A	c.(853-855)CCG>CCA	p.P285P		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	285	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AGTTCCTCCCGCCAGGCTACC	0.522													13	73					0	0	0	0
C1orf168	199920	broad.mit.edu	37	1	57257877	57257877	+	Silent	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:57257877G>T	uc001cym.3	-	2	1015	c.609C>A	c.(607-609)CCC>CCA	p.P203P	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.P203P	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	203										ovary(3)|skin(2)	5						GTAATATTTTGGGGGCCACCA	0.488													9	123					2.17888e-05	2.39805e-05	1	0
PTGFR	5737	broad.mit.edu	37	1	79002110	79002110	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:79002110G>A	uc001din.2	+	3	1084	c.818G>A	c.(817-819)GGA>GAA	p.G273E	PTGFR_uc001dim.2_Missense_Mutation_p.E297K	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	273	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GCCAACATTGGAATAAATGGA	0.343													4	56					0	0	0	0
KCNA3	3738	broad.mit.edu	37	1	111216780	111216780	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:111216780G>A	uc001dzv.1	-	1	876	c.652C>T	c.(652-654)CGC>TGC	p.R218C		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	218						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACACCTGGCGCTGGAAGTCG	0.672													9	58					0	0	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020169	156020169	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:156020169C>T	uc001fna.2	-	4	678	c.654G>A	c.(652-654)ATG>ATA	p.M218I	UBQLN4_uc010pgx.1_Missense_Mutation_p.M198I	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	218						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGGCCATAATCATGTGACGCA	0.522													6	137					0	0	0	0
DDX59	83479	broad.mit.edu	37	1	200619738	200619738	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:200619738C>G	uc009wzk.2	-	5	1372	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	DDX59_uc010ppl.1_Missense_Mutation_p.D377H	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	377	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GTCTGACAATCATTAGGAATG	0.353													3	39					0	0	0	0
C1orf69	200205	broad.mit.edu	37	1	228362900	228362900	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:228362900G>A	uc001hsl.3	+	3	846	c.757G>A	c.(757-759)GTG>ATG	p.V253M	C1orf69_uc010pvw.1_Missense_Mutation_p.V60M	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	253					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CATGAACGGCGTGAGCTTCAC	0.642													10	92					0	0	0	0
C1orf198	84886	broad.mit.edu	37	1	230979431	230979431	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:230979431C>T	uc001hub.2	-	3	640	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	C1orf198_uc009xfh.1_Missense_Mutation_p.R69Q|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.R161Q	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	199											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CCCCTCCCCTCGGGACCGCTC	0.627													24	111					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224880	248224880	+	Silent	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:248224880C>A	uc001idx.1	+	1	897	c.897C>A	c.(895-897)GCC>GCA	p.A299A	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGATGGGGGCCCTGACACGAG	0.493													10	58					0.00621372	0.00660429	1	0
OR2M3	127062	broad.mit.edu	37	1	248366774	248366774	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:248366774C>G	uc010pzg.1	+	1	405	c.405C>G	c.(403-405)CTC>CTG	p.L135L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACACCAATCTCATGAGCCCTA	0.438													13	247					0	0	0	0
SEC61A2	55176	broad.mit.edu	37	10	12197794	12197794	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:12197794G>A	uc001ile.2	+	7	627	c.480G>A	c.(478-480)TTG>TTA	p.L160L	SEC61A2_uc010qbq.1_Silent_p.L138L|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Silent_p.L160L	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	160	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				TTGCTGGTTTGATTGTGCTGC	0.473													34	303					0	0	0	0
ACBD5	91452	broad.mit.edu	37	10	27512312	27512312	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:27512312T>A	uc010qdp.1	-	5	636	c.445A>T	c.(445-447)ATT>TTT	p.I149F	ACBD5_uc010qdm.1_Missense_Mutation_p.I147F|ACBD5_uc010qdn.1_Missense_Mutation_p.I40F|ACBD5_uc010qdo.1_Missense_Mutation_p.I40F|ACBD5_uc001ito.2_Missense_Mutation_p.I114F|ACBD5_uc001itp.2_Missense_Mutation_p.I40F|ACBD5_uc001itq.2_Missense_Mutation_p.I40F|ACBD5_uc001itr.1_5'UTR	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	147					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						TCCTCGACAATTTCATAAAAT	0.318													3	51					0	0	0	0
DNAJB12	54788	broad.mit.edu	37	10	74114714	74114714	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:74114714A>C	uc010qjv.1	-	1	194	c.44T>G	c.(43-45)GTG>GGG	p.V15G	DNAJB12_uc001jsz.2_Missense_Mutation_p.V15G|DNAJB12_uc001jta.2_Missense_Mutation_p.V15G	NM_017626	NP_060096	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	Error:Variant_position_missing_in_Q9NXW2_after_alignment					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding				0						GGGCTGCGCCACCCGCCGGCG	0.662													10	19					0	0	0	0
IFIT2	3433	broad.mit.edu	37	10	91066451	91066451	+	Silent	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:91066451A>T	uc009xts.2	+	2	913	c.738A>T	c.(736-738)GTA>GTT	p.V246V	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	246					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				CCCCAGGTGTAACAGATGTTC	0.438													19	54					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123970684	123970684	+	Silent	SNP	G	A	A	rs35532970		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:123970684G>A	uc001lfv.2	+	9	7104	c.6744G>A	c.(6742-6744)TCG>TCA	p.S2248S	TACC2_uc001lfw.2_Silent_p.S394S|TACC2_uc009xzx.2_Silent_p.S2203S|TACC2_uc010qtv.1_Silent_p.S2252S|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Silent_p.S326S|TACC2_uc001lga.2_Silent_p.S326S|TACC2_uc009xzy.2_Silent_p.S326S|TACC2_uc001lgb.2_Silent_p.S283S|TACC2_uc010qtw.1_Silent_p.S343S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2248						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TAACCCCATCGGATAGCGGGG	0.602													5	55					0	0	0	0
CUZD1	50624	broad.mit.edu	37	10	124598737	124598737	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:124598737C>T	uc001lgq.2	-	3	576	c.244G>A	c.(244-246)GAT>AAT	p.D82N	CUZD1_uc001lgp.2_5'Flank|CUZD1_uc009yad.2_5'Flank|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.D82N|CUZD1_uc010qtz.1_Missense_Mutation_p.D82N	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	82	CUB 1.|Extracellular (Potential).				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CAGCTTCCATCTGGATCAAGC	0.453													7	107					0	0	0	0
NLRP6	171389	broad.mit.edu	37	11	281225	281225	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:281225C>G	uc010qvs.1	+	4	1491	c.1491C>G	c.(1489-1491)TTC>TTG	p.F497L	NLRP6_uc010qvt.1_Missense_Mutation_p.F497L	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	497	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTACCAGTTCATCGACCAGA	0.627													5	122					0	0	0	0
NUP98	4928	broad.mit.edu	37	11	3727721	3727721	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:3727721G>C	uc001lyh.2	-	21	3170	c.2879C>G	c.(2878-2880)TCA>TGA	p.S960*	NUP98_uc001lyi.2_Nonsense_Mutation_p.S960*|NUP98_uc001lyg.2_Nonsense_Mutation_p.S28*	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	977					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AATATGTGTTGAGGCAGACAC	0.423			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								4	127					0	0	0	0
PSMA1	5682	broad.mit.edu	37	11	14540580	14540580	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:14540580T>C	uc001mlk.2	-	2	157	c.11A>G	c.(10-12)AAT>AGT	p.N4S	PSMA1_uc001mll.2_Missense_Mutation_p.N10S|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_5'UTR|PSMA1_uc010rcq.1_Missense_Mutation_p.N4S	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	4					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						GTCATACTGATTTCGAAACTA	0.308													10	37					0	0	0	0
LDHC	3948	broad.mit.edu	37	11	18467778	18467778	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:18467778G>A	uc001mon.3	+	7	844	c.732G>A	c.(730-732)CTG>CTA	p.L244L	LDHC_uc001mom.3_Silent_p.L244L|LDHC_uc009yhp.2_Intron|LDHC_uc001moo.3_Silent_p.L128L|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Intron	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	244					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TTATCAAGCTGAAGGGGTATA	0.373													6	78					0	0	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110451310	110451310	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:110451310C>G	uc001pkz.1	-	16	2645	c.2360G>C	c.(2359-2361)GGA>GCA	p.G787A	ARHGAP20_uc001pky.1_Missense_Mutation_p.G764A|ARHGAP20_uc009yyb.1_Missense_Mutation_p.G751A|ARHGAP20_uc001pla.1_Missense_Mutation_p.G751A|ARHGAP20_uc001plb.2_Missense_Mutation_p.G330A	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	787					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CACGTGATTTCCTTCACTACC	0.413													5	97					0	0	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919137	21919137	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:21919137C>G	uc001rff.2	-	3	1133	c.795G>C	c.(793-795)TTG>TTC	p.L265F		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	265	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	GGCAGATGATCAAAGGGGCCA	0.478													15	34					0	0	0	0
FAR2	55711	broad.mit.edu	37	12	29486610	29486610	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:29486610C>T	uc001ris.3	+	12	1578	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	FAR2_uc001rit.2_Silent_p.I477I|FAR2_uc009zjm.2_Silent_p.I380I	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	477	Helical; (Potential).				ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TCTTCCTTATCGCCTGGCGCC	0.428													12	185					0	0	0	0
SOAT2	8435	broad.mit.edu	37	12	53509201	53509201	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:53509201C>T	uc001sbv.2	+	6	559	c.471C>T	c.(469-471)ATC>ATT	p.I157I	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	157	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						ACCTACTGATCTTCAGCTTCG	0.552													3	42					0	0	0	0
METTL7B	196410	broad.mit.edu	37	12	56075775	56075775	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:56075775C>T	uc010spr.1	+	1	446	c.237C>T	c.(235-237)TGC>TGT	p.C79C		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	79							methyltransferase activity				0						AGCTGGGCTGCGGAACCGGAG	0.572													9	29					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109684111	109684111	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:109684111A>G	uc001tob.2	+	39	5548	c.5429A>G	c.(5428-5430)TAC>TGC	p.Y1810C	ACACB_uc001toc.2_Missense_Mutation_p.Y1810C|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.Y476C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1810	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GACCTTCTGTACCTGCGGGCA	0.562													4	107					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120166409	120166409	+	Silent	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:120166409G>C	uc001txi.1	-	27	3416	c.3363C>G	c.(3361-3363)CTC>CTG	p.L1121L	CIT_uc001txh.1_Silent_p.L655L|CIT_uc001txj.1_Silent_p.L1163L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1121	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCAGGTCATTGAGCTAGACAT	0.438													7	143					0	0	0	0
LNX2	222484	broad.mit.edu	37	13	28136648	28136648	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:28136648C>A	uc001url.3	-	5	1435	c.1126G>T	c.(1126-1128)GCC>TCC	p.A376S	LNX2_uc001urm.1_Missense_Mutation_p.A376S	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	376	PDZ 2.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CCGTCCTGGGCAGCCAACCCC	0.532													20	150					1.1804e-14	1.38084e-14	1	0
FLT3	2322	broad.mit.edu	37	13	28609671	28609671	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:28609671G>C	uc001urw.2	-	12	1640	c.1558C>G	c.(1558-1560)CTT>GTT	p.L520V	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L520V	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	520	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GATGTGCCAAGGGAATTGTAT	0.453			Mis|O		AML|ALL								5	84					0	0	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559752	46559752	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:46559752C>T	uc010tfw.1	-	9	1406	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q	ZC3H13_uc001vas.1_Missense_Mutation_p.R467Q|ZC3H13_uc001vat.1_Missense_Mutation_p.R467Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	467	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TAGTTCCCTTCGGTCCCTAGT	0.507													12	181					0	0	0	0
FAM10A4	145165	broad.mit.edu	37	13	50746753	50746753	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:50746753T>G	uc001vej.2	+	1	600	c.529T>G	c.(529-531)TCA>GCA	p.S177A	DLEU1_uc010adl.1_Intron|DLEU1_uc001vee.1_Intron|DLEU1_uc010adm.1_Intron|DLEU1_uc010adn.1_Intron|DLEU1_uc001vef.1_Intron|DLEU1_uc001veg.1_Intron|DLEU1_uc010tgn.1_Intron|DLEU1_uc001vei.1_Intron|DLEU1_uc010ado.1_Intron|DLEU1_uc010adp.1_Intron	NR_002183				SubName: Full=ST13 protein;												0						AAATCCTGATTCAGCTCAGCC	0.488													9	152					0	0	0	0
NEK5	341676	broad.mit.edu	37	13	52660423	52660423	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:52660423C>A	uc001vge.2	-	16	1609	c.1469G>T	c.(1468-1470)AGA>ATA	p.R490I		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	490							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCTGGTTCTCTCCCCATCTT	0.363													13	42					0.000151284	0.000165523	1	0
CHD8	57680	broad.mit.edu	37	14	21870656	21870656	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:21870656C>T	uc001was.1	-	19	2978	c.2884G>A	c.(2884-2886)GCA>ACA	p.A962T	CHD8_uc001war.1_Missense_Mutation_p.A858T|CHD8_uc001wav.1_Missense_Mutation_p.A404T	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1241	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TGACATCGTGCCTGGGCCTGG	0.413													17	26					0	0	0	0
COCH	1690	broad.mit.edu	37	14	31358870	31358870	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:31358870T>G	uc001wqr.2	+	12	1606	c.1526T>G	c.(1525-1527)CTG>CGG	p.L509R	COCH_uc001wqp.2_Missense_Mutation_p.L509R|COCH_uc001wqq.3_Intron|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.L360R	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	509	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CTGGATGACCTGAAAGATATG	0.388													7	39					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44975153	44975153	+	Silent	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:44975153A>T	uc001wvn.2	-	1	1347	c.1038T>A	c.(1036-1038)CTT>CTA	p.L346L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	346	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTTCAGCCAGAAGCTCTACAG	0.507													13	111					0	0	0	0
SLC39A9	55334	broad.mit.edu	37	14	69890883	69890883	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:69890883G>A	uc001xle.2	+	2	849	c.169G>A	c.(169-171)GAA>AAA	p.E57K	SLC39A9_uc001xld.3_RNA|SLC39A9_uc010aqx.2_Missense_Mutation_p.E57K|SLC39A9_uc001xlf.3_Missense_Mutation_p.E57K|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	57					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		CATCGTGCCTGAAGGAGTACA	0.458													8	37					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94060062	94060062	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:94060062G>A	uc001ybv.1	+	20	2621	c.2538G>A	c.(2536-2538)CTG>CTA	p.L846L	KIAA1409_uc001ybs.1_Silent_p.L846L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1023						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCTCTCAGCTGTCTTCCCTGG	0.473													27	108					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411954	105411954	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:105411954G>A	uc010axc.1	-	7	9954	c.9834C>T	c.(9832-9834)GTC>GTT	p.V3278V	AHNAK2_uc001ypx.2_Silent_p.V3178V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3278						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGCCTCGACGTCCACCT	0.607													30	234					0	0	0	0
THBS1	7057	broad.mit.edu	37	15	39881288	39881288	+	Splice_Site	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:39881288G>A	uc001zkh.2	+	11	1952	c.1773_splice	c.e11+1	p.E591_splice	THBS1_uc010bbi.2_Splice_Site_p.E63_splice	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor						activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TGTTGATGAGGTGAGGAACTG	0.517													6	136					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85163919	85163919	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:85163919G>C	uc002bkr.2	+	3	719	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ZSCAN2_uc010bmz.1_Missense_Mutation_p.E163Q|ZSCAN2_uc010bna.2_Missense_Mutation_p.E15Q|ZSCAN2_uc010uox.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoy.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoz.1_Missense_Mutation_p.E164Q	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	165					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GGAAATGCCTGAAGGTGAAAG	0.473													6	119					0	0	0	0
IQGAP1	8826	broad.mit.edu	37	15	91020962	91020962	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:91020962G>C	uc002bpl.1	+	26	3271	c.3170G>C	c.(3169-3171)AGT>ACT	p.S1057T		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1057	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ATGGTTGTAAGTTTCAACCGT	0.408													5	55					0	0	0	0
ARRDC4	91947	broad.mit.edu	37	15	98512388	98512388	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:98512388T>C	uc010bom.2	+	5	820	c.661T>C	c.(661-663)TGT>CGT	p.C221R	ARRDC4_uc002bui.3_Missense_Mutation_p.C134R	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	221					signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			AATAGAAAATTGTTCCTCTCG	0.393													15	43					0	0	0	0
NDUFB10	4716	broad.mit.edu	37	16	2011519	2011519	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:2011519C>G	uc002cni.2	+	3	400	c.291C>G	c.(289-291)ATC>ATG	p.I97M	NDUFB10_uc002cnj.2_Missense_Mutation_p.I97M	NM_004548	NP_004539	O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	97					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	AAGAAATTATCAACATTATGC	0.473													6	192					0	0	0	0
C16orf45	89927	broad.mit.edu	37	16	15677026	15677026	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:15677026G>A	uc002ddo.2	+	5	619	c.433G>A	c.(433-435)GAC>AAC	p.D145N	C16orf45_uc002ddp.2_Missense_Mutation_p.D128N	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	145										ovary(1)	1						GCAAGAAGAAGACAAGGAAAT	0.388													17	104					0	0	0	0
RBBP6	5930	broad.mit.edu	37	16	24552017	24552017	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:24552017A>G	uc002dmh.2	+	1	1110	c.70A>G	c.(70-72)ATC>GTC	p.I24V	RBBP6_uc010vcb.1_Intron|RBBP6_uc002dmg.2_Missense_Mutation_p.I24V|RBBP6_uc002dmi.2_Missense_Mutation_p.I24V|RBBP6_uc010bxr.2_Missense_Mutation_p.I24V	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	24	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TGGGCTCCACATCTCCCTCTG	0.483													14	59					0	0	0	0
ZNF48	197407	broad.mit.edu	37	16	30410135	30410135	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:30410135G>T	uc002dya.1	+	2	1623	c.1564G>T	c.(1564-1566)GGC>TGC	p.G522C	ZNF48_uc002dxz.1_Missense_Mutation_p.G399C	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	522	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAACCCACCTGGCCCAGTACC	0.677													5	110					0.00116845	0.00124903	1	0
NLRC5	84166	broad.mit.edu	37	16	57101666	57101666	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:57101666C>T	uc002ekk.1	+	36	4650	c.4425C>T	c.(4423-4425)CTC>CTT	p.L1475L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Silent_p.L17L|NLRC5_uc002ekr.1_Silent_p.L362L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1475	LRR 15.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGTTAACCTCTGTGAGGACG	0.507													5	79					0	0	0	0
EDC4	23644	broad.mit.edu	37	16	67913808	67913808	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:67913808G>T	uc002eur.2	+	16	2043	c.1877G>T	c.(1876-1878)AGC>ATC	p.S626I	EDC4_uc010cer.2_Missense_Mutation_p.S245I|EDC4_uc010vkg.1_Missense_Mutation_p.S558I|EDC4_uc002eus.2_Missense_Mutation_p.S356I|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	626	Ser-rich.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		agcagcagtagcagcagcTCC	0.448													20	49					5.35267e-07	6.07071e-07	1	0
HYDIN	54768	broad.mit.edu	37	16	70867859	70867859	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:70867859C>A	uc002ezr.2	-	79	13735	c.13607G>T	c.(13606-13608)GGA>GTA	p.G4536V	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4537										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CACCACGGGTCCAAAGGGAAT	0.587													7	11					2.17888e-05	2.39805e-05	1	0
MYO1C	4641	broad.mit.edu	37	17	1387008	1387008	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:1387008G>A	uc002fsp.2	-	3	463	c.243C>T	c.(241-243)GGC>GGT	p.G81G	MYO1C_uc002fsn.2_Silent_p.G62G|MYO1C_uc002fso.2_Silent_p.G46G|MYO1C_uc010vqj.1_Silent_p.G46G|MYO1C_uc010vqk.1_Silent_p.G57G	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	81	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCAGGACGGGGCCAATGTAGG	0.433													3	16					0	0	0	0
PRPF8	10594	broad.mit.edu	37	17	1562841	1562841	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:1562841C>A	uc002fte.2	-	32	5062	c.4948G>T	c.(4948-4950)GAT>TAT	p.D1650Y		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1650						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCCATCACATCCCTGAGGATG	0.527													9	78					0.000274275	0.000294885	1	0
MYOCD	93649	broad.mit.edu	37	17	12666526	12666526	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:12666526C>G	uc002gnn.2	+	13	2681	c.2382C>G	c.(2380-2382)ATC>ATG	p.I794M	MYOCD_uc002gno.2_Missense_Mutation_p.I842M|MYOCD_uc002gnq.2_Missense_Mutation_p.I518M	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	794					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCAGCCAGATCCCCTTTGATC	0.483													6	110					0	0	0	0
SREBF1	6720	broad.mit.edu	37	17	17718569	17718569	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:17718569G>A	uc002gru.1	-	13	2652	c.2458C>T	c.(2458-2460)CCC>TCC	p.P820S	SREBF1_uc002grp.1_Missense_Mutation_p.P439S|SREBF1_uc002grq.1_Missense_Mutation_p.P339S|SREBF1_uc002grr.1_Missense_Mutation_p.P566S|SREBF1_uc002grs.1_Missense_Mutation_p.P796S|SREBF1_uc002grt.1_Missense_Mutation_p.P850S|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	820	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CTGGGGTTGGGCTGGGTCACA	0.617													8	104					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18040913	18040913	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:18040913A>G	uc010vxh.1	+	15	5133	c.4795A>G	c.(4795-4797)AGC>GGC	p.S1599G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1599	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GAGCTTCAACAGCTTTGAGCA	0.532													5	56					0	0	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542													4	72					0	0	0	0
KIAA0100	9703	broad.mit.edu	37	17	26948139	26948139	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:26948139G>A	uc002hbu.2	-	28	5208	c.5109C>T	c.(5107-5109)ATC>ATT	p.I1703I	KIAA0100_uc002hbt.2_Silent_p.I32I	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1703						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AACGCGAAATGATCCGCTGGA	0.448													4	64					0	0	0	0
AOC3	8639	broad.mit.edu	37	17	41004139	41004139	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:41004139C>T	uc002ibv.2	+	1	939	c.779C>T	c.(778-780)ACT>ATT	p.T260I		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	260	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GCCCGCTGGACTATCCAGAAG	0.597													9	40					0	0	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475597	42475597	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:42475597G>A	uc002igw.1	-	8	3912	c.3848C>T	c.(3847-3849)GCA>GTA	p.A1283V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1205V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1205V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1283						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACTGGGAGGTGCATAACTGGG	0.592													7	177					0	0	0	0
DNAH17	8632	broad.mit.edu	37	17	76506502	76506502	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:76506502G>A	uc010wtu.1	-	1	252	c.75C>T	c.(73-75)ATC>ATT	p.I25I						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCTTGTCCACGATGTTGCGGA	0.532													7	199					0	0	0	0
SIRT7	51547	broad.mit.edu	37	17	79872320	79872320	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:79872320G>A	uc002kcj.1	-	7	699	c.666C>T	c.(664-666)GGC>GGT	p.G222G	SIRT7_uc002kck.1_Silent_p.G73G|SIRT7_uc002kcl.1_Silent_p.G140G	NM_016538	NP_057622	Q9NRC8	SIRT7_HUMAN	sirtuin 7	222	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGCAGGTCCGGCCTGTCTGGT	0.632													9	28					0	0	0	0
UTS2R	2837	broad.mit.edu	37	17	80332288	80332288	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:80332288G>A	uc010wvl.1	+	1	88	c.88G>A	c.(88-90)GCA>ACA	p.A30T		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	30	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CGGCCCCAACGCAACCCTCAA	0.711													3	14					0	0	0	0
DPP9	91039	broad.mit.edu	37	19	4704050	4704050	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:4704050G>A	uc002mba.2	-	7	875	c.617C>T	c.(616-618)CCG>CTG	p.P206L	DPP9_uc002mbb.2_Missense_Mutation_p.P206L|DPP9_uc002mbc.2_Missense_Mutation_p.P206L	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	177					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GATTTCCAGCGGTTTCATAGG	0.632													8	41					0	0	0	0
HOMER3	9454	broad.mit.edu	37	19	19042181	19042181	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:19042181C>T	uc002nku.2	-	8	1500	c.847G>A	c.(847-849)GAG>AAG	p.E283K	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Missense_Mutation_p.E247K|HOMER3_uc010ebz.2_Missense_Mutation_p.E283K|HOMER3_uc002nkw.2_Missense_Mutation_p.E283K|HOMER3_uc002nkv.2_Missense_Mutation_p.E283K	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	283	Potential.				metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			TCCAGGGCCTCGCGGGGCCCC	0.627													6	99					0	0	0	0
ZNF527	84503	broad.mit.edu	37	19	37880095	37880095	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:37880095G>T	uc010efk.1	+	5	1255	c.1144G>T	c.(1144-1146)GGT>TGT	p.G382C	ZNF527_uc002ogf.3_Missense_Mutation_p.G350C|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATTCACACAGGTGAGAAACC	0.433													8	38					1.12685e-05	1.25506e-05	1	0
PSG1	5669	broad.mit.edu	37	19	43382262	43382262	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:43382262T>C	uc002ovb.2	-	2	371	c.233A>G	c.(232-234)TAC>TGC	p.Y78C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.Y78C|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.Y78C|PSG1_uc010eio.1_Missense_Mutation_p.Y78C|PSG1_uc002oux.1_Missense_Mutation_p.Y7C|PSG1_uc002ouy.1_Missense_Mutation_p.Y78C|PSG1_uc002ouz.1_Missense_Mutation_p.Y78C|PSG1_uc002ova.1_Missense_Mutation_p.Y78C|PSG1_uc002ovc.2_Missense_Mutation_p.Y78C|PSG1_uc002ovd.1_Missense_Mutation_p.Y78C	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	78	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGATGTAATGTAATGGTAGAG	0.433													63	268					0	0	0	0
ZNF471	57573	broad.mit.edu	37	19	57037232	57037232	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:57037232A>G	uc002qnh.2	+	5	1929	c.1796A>G	c.(1795-1797)TAT>TGT	p.Y599C		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	599	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		CAAAGGCCCTATCAGTGTTTT	0.413													10	42					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57327549	57327549	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:57327549G>A	uc002qnu.2	-	7	2612	c.2261C>T	c.(2260-2262)TCT>TTT	p.S754F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.S725F|PEG3_uc002qnv.2_Missense_Mutation_p.S754F|PEG3_uc002qnw.2_Missense_Mutation_p.S630F|PEG3_uc002qnx.2_Missense_Mutation_p.S628F|PEG3_uc010etr.2_Missense_Mutation_p.S754F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	754					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAGGGGTTAGAGCTAATGGT	0.413													10	164					0	0	0	0
GALNT14	79623	broad.mit.edu	37	2	31215732	31215732	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:31215732G>A	uc002rnr.2	-	2	890	c.271C>T	c.(271-273)CGG>TGG	p.R91W	GALNT14_uc002rnq.2_Missense_Mutation_p.R71W|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R56W|GALNT14_uc010ezo.1_Missense_Mutation_p.R91W|GALNT14_uc010ezp.1_Missense_Mutation_p.R62W	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	91	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGATGGCCCGATTGCTGGAG	0.562													6	89					0	0	0	0
EFEMP1	2202	broad.mit.edu	37	2	56097911	56097911	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:56097911T>G	uc002rzh.2	-	10	1594	c.1264A>C	c.(1264-1266)ACC>CCC	p.T422P	EFEMP1_uc002rzi.2_Missense_Mutation_p.T422P|EFEMP1_uc002rzj.2_Missense_Mutation_p.T422P|EFEMP1_uc010ypc.1_Missense_Mutation_p.T284P	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	422	Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTATTGATGGTGTTGGCATAA	0.418													3	58					0	0	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049988	69049988	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:69049988G>C	uc002seu.2	+	10	2078	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E573Q|ARHGAP25_uc010yql.1_Missense_Mutation_p.E533Q|ARHGAP25_uc002sew.2_Missense_Mutation_p.E565Q|ARHGAP25_uc002sex.2_Missense_Mutation_p.E566Q|ARHGAP25_uc002sey.2_Missense_Mutation_p.E299Q	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	572	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GCAAATGTATGAGGAACAGAT	0.448													3	54					0	0	0	0
PCGF1	84759	broad.mit.edu	37	2	74733102	74733102	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:74733102C>T	uc002slz.2	-	5	533	c.507G>A	c.(505-507)TTG>TTA	p.L169L	LBX2_uc002slw.2_5'Flank|PCGF1_uc002sly.2_Silent_p.L86L	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	169					histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						GGCACAGGTTCAACTGCTCAT	0.577													13	197					0	0	0	0
GGCX	2677	broad.mit.edu	37	2	85781368	85781368	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:85781368C>G	uc002sps.2	-	7	893	c.787G>C	c.(787-789)GAC>CAC	p.D263H	GGCX_uc010yss.1_Missense_Mutation_p.D102H|GGCX_uc010yst.1_Missense_Mutation_p.D206H	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	263	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	GCTGAGAGGTCAAGCAGCAGC	0.507													6	183					0	0	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514726	113514726	+	Missense_Mutation	SNP	G	C	C	rs77207496	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:113514726G>C	uc002tie.2	-	4	301	c.222C>G	c.(220-222)ATC>ATG	p.I74M	CKAP2L_uc002tif.2_Translation_Start_Site|CKAP2L_uc010yxp.1_Translation_Start_Site|CKAP2L_uc010yxq.1_Translation_Start_Site	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	74						centrosome					0						GTTTAATGCTGATGGACCTTT	0.413													7	183					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141250263	141250263	+	Splice_Site	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:141250263C>G	uc002tvj.1	-	57	10007	c.9035_splice	c.e57-1	p.D3012_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTTCTTCATCTAAACACCAA	0.338										TSP Lung(27;0.18)			6	67					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			5	58					0	0	0	0
ARMC9	80210	broad.mit.edu	37	2	232123816	232123816	+	Splice_Site	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:232123816G>A	uc002vrq.3	+	11	1138	c.1026_splice	c.e11+1	p.W342_splice	ARMC9_uc002vrp.3_Splice_Site_p.W342_splice	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9								binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TCTGCGCTGGGTAGGTACCTT	0.438													11	27					0	0	0	0
PRNT	149830	broad.mit.edu	37	20	4713344	4713344	+	RNA	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr20:4713344A>T	uc002wlb.2	-	2		c.680T>A			PRNT_uc010zqp.1_RNA|PRNT_uc010zqq.1_RNA	NR_024268				Homo sapiens mRNA for putative M8 protein, isoform 2.												0						caagcggtccagtacagtggg	0													3	3					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61542619	61542619	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr20:61542619C>T	uc002ydr.1	-	3	610	c.346G>A	c.(346-348)GAA>AAA	p.E116K	DIDO1_uc002yds.1_Missense_Mutation_p.E116K|DIDO1_uc002ydt.1_Missense_Mutation_p.E116K|DIDO1_uc002ydu.1_Missense_Mutation_p.E116K|DIDO1_uc002ydv.1_Missense_Mutation_p.E116K|DIDO1_uc002ydw.1_Missense_Mutation_p.E116K|DIDO1_uc002ydx.1_Missense_Mutation_p.E116K|DIDO1_uc011aao.1_Missense_Mutation_p.E116K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	116					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAGCGCTTTCCACGCTGCCC	0.637													6	41					0	0	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61914181	61914181	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr20:61914181T>G	uc002yem.2	+	9	807	c.695T>G	c.(694-696)TTT>TGT	p.F232C	ARFGAP1_uc011aas.1_Missense_Mutation_p.F179C|ARFGAP1_uc011aat.1_Missense_Mutation_p.F119C|ARFGAP1_uc002yel.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yen.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yeo.1_5'Flank	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	232					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GCTACAAAGTTTGGATCCCAA	0.507													15	42					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10996103	10996103	+	RNA	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr21:10996103G>C	uc002yis.1	-	12		c.2083C>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCCTTGCCCAGTTCGACTTCT	0.408													4	59					0	0	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19704465	19704465	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr21:19704465C>G	uc002ykw.2	-	14	1621	c.1590G>C	c.(1588-1590)CTG>CTC	p.L530L		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	530	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTGGCTCCCACAGCTCAAAAG	0.403													4	56					0	0	0	0
CECR5	27440	broad.mit.edu	37	22	17629399	17629399	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:17629399C>T	uc002zmf.2	-	3	410	c.382G>A	c.(382-384)GAG>AAG	p.E128K	CECR5_uc002zme.2_5'UTR|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.E98K	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	128							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				TCATGGTACTCGGAGAAGAGC	0.557													14	260					0	0	0	0
SREBF2	6721	broad.mit.edu	37	22	42294718	42294718	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:42294718G>T	uc003bbi.2	+	15	2840	c.2671G>T	c.(2671-2673)GAC>TAC	p.D891Y	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA|uc011api.1_5'Flank|MIR33A_hsa-mir-33a|MI0000091_5'Flank	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	891	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						GCTCCAGGGAGACGATGCAGC	0.567													13	23					9.31168e-06	1.04336e-05	1	0
MPPED1	758	broad.mit.edu	37	22	43870809	43870809	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:43870809C>T	uc011apv.1	+	4	823	c.600C>T	c.(598-600)ACC>ACT	p.T200T	MPPED1_uc011apw.1_Silent_p.T94T|MPPED1_uc011apx.1_Silent_p.T42T|MPPED1_uc011apy.1_Silent_p.T200T|MPPED1_uc011apz.1_Silent_p.T233T	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	200							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CGGAGGTCACCGTGCGGGGCT	0.522													24	54					0	0	0	0
TGFBR2	7048	broad.mit.edu	37	3	30715720	30715720	+	Missense_Mutation	SNP	C	T	T	rs104893811		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:30715720C>T	uc003ceo.2	+	5	1760	c.1378C>T	c.(1378-1380)CGC>TGC	p.R460C	TGFBR2_uc003cen.2_Missense_Mutation_p.R485C	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	460	Protein kinase.|Cytoplasmic (Potential).		R -> C (in AAT3).|R -> H (in AAT3).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						AATGACATCTCGCTGTAATGC	0.458													7	63					0	0	0	0
ATRIP	84126	broad.mit.edu	37	3	48488144	48488144	+	5'Flank	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:48488144C>G	uc003ctf.1	+						ATRIP_uc011bbj.1_5'UTR|ATRIP_uc003ctg.1_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1						DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCGGGGCACTCGCGGCGGAGG	0.746								Other_conserved_DNA_damage_response_genes					3	23					0	0	0	0
ITIH4	3700	broad.mit.edu	37	3	52857598	52857598	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:52857598G>T	uc003dfz.2	-	11	1549	c.1513C>A	c.(1513-1515)CTC>ATC	p.L505I	ITIH4_uc011bel.1_Missense_Mutation_p.L235I|ITIH4_uc003dfy.2_Missense_Mutation_p.L369I|ITIH4_uc011bem.1_Missense_Mutation_p.L505I|ITIH4_uc011ben.1_Missense_Mutation_p.L505I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	505					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GTGGCTGTGAGCACATCAGGC	0.612													8	22					0.000157383	0.000171189	1	0
CACNA1D	776	broad.mit.edu	37	3	53844020	53844020	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:53844020G>A	uc003dgv.3	+	47	6050	c.5887G>A	c.(5887-5889)GGC>AGC	p.G1963S	CACNA1D_uc003dgu.3_Missense_Mutation_p.G1983S|CACNA1D_uc003dgy.3_Missense_Mutation_p.G1939S|CACNA1D_uc003dgw.3_Missense_Mutation_p.G1630S|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1963	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCAGTTGCCGGCCTAGATTC	0.612													16	73					0	0	0	0
C3orf38	285237	broad.mit.edu	37	3	88205752	88205752	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:88205752G>A	uc003dqw.2	+	4	1268	c.957G>A	c.(955-957)CAG>CAA	p.Q319Q		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	319					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		ATGTAAAGCAGGCTTCGGATA	0.408													20	70					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	rs121913273		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	50					0	0	0	0
ZBTB49	166793	broad.mit.edu	37	4	4314793	4314793	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:4314793G>A	uc003ghu.2	+	5	1503	c.1328G>A	c.(1327-1329)CGA>CAA	p.R443Q	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_Intron|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	443	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACTCACTTACGACGGCATTCT	0.408													7	50					0	0	0	0
EVC	2121	broad.mit.edu	37	4	5800433	5800433	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:5800433A>G	uc003gil.1	+	15	2402	c.2218A>G	c.(2218-2220)ATG>GTG	p.M740V	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	740					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GCAGCAGCACATGGAGTGCGC	0.652													6	15					0	0	0	0
AFAP1	60312	broad.mit.edu	37	4	7873772	7873772	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:7873772G>C	uc003gkg.1	-	2	307	c.34C>G	c.(34-36)CTT>GTT	p.L12V	AFAP1_uc011bwk.1_Missense_Mutation_p.L12V	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	12						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						AGGAGTTCAAGAAAGAGACGA	0.383													3	61					0	0	0	0
SOD3	6649	broad.mit.edu	37	4	24801554	24801554	+	Silent	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:24801554G>C	uc003gqz.2	+	2	616	c.411G>C	c.(409-411)GTG>GTC	p.V137V	SOD3_uc003gqy.1_RNA	NM_003102	NP_003093	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular precursor	137					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding				0		Breast(46;0.0503)				CGCTGGCCGTGCCGCACCCGC	0.751													4	26					0	0	0	0
ADAD1	132612	broad.mit.edu	37	4	123336584	123336584	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:123336584C>T	uc003ieo.2	+	11	1532	c.1300C>T	c.(1300-1302)CGT>TGT	p.R434C	ADAD1_uc003iep.2_Missense_Mutation_p.R423C|ADAD1_uc003ieq.2_Missense_Mutation_p.R416C	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	434	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TATAAAGCAACGTGTTGATGA	0.368													15	75					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187629100	187629100	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187629100G>A	uc003izf.2	-	2	2070	c.1882C>T	c.(1882-1884)CGA>TGA	p.R628*	FAT1_uc010iso.1_Nonsense_Mutation_p.R628*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	628	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATTAGCGATCGCTTTAATGAC	0.403										HNSCC(5;0.00058)			6	63					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630411	187630411	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187630411G>A	uc003izf.2	-	2	759	c.571C>T	c.(571-573)CGA>TGA	p.R191*	FAT1_uc010iso.1_Nonsense_Mutation_p.R191*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	191	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATATCTGTTCGATCTTTAAAA	0.433										HNSCC(5;0.00058)			13	115					0	0	0	0
MIER3	166968	broad.mit.edu	37	5	56234739	56234739	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:56234739C>G	uc003jrd.1	-	4	311	c.286G>C	c.(286-288)GAT>CAT	p.D96H	MIER3_uc003jqz.1_Missense_Mutation_p.D33H|MIER3_uc003jra.1_Missense_Mutation_p.D96H|MIER3_uc003jrb.1_5'UTR|MIER3_uc003jrc.1_Missense_Mutation_p.D101H	NM_152622	NP_689835	Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GGTAGTTCATCTGCCAGTTCA	0.393													6	63					0	0	0	0
SERINC5	256987	broad.mit.edu	37	5	79473175	79473175	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:79473175C>T	uc003kgj.2	-	4	548	c.419G>A	c.(418-420)GGA>GAA	p.G140E	SERINC5_uc003kgk.2_Missense_Mutation_p.G140E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.G140E|SERINC5_uc011ctj.1_Missense_Mutation_p.G140E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	140	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GAAGAAAGCTCCTGAGCACAT	0.393													6	58					0	0	0	0
C5orf13	9315	broad.mit.edu	37	5	111066653	111066653	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:111066653G>A	uc003kpl.2	-	3	651	c.172C>T	c.(172-174)CGC>TGC	p.R58C	C5orf13_uc011cvr.1_Missense_Mutation_p.R102C|C5orf13_uc011cvs.1_Missense_Mutation_p.R92C|C5orf13_uc003kpk.2_Intron|C5orf13_uc003kpm.2_Missense_Mutation_p.R58C|C5orf13_uc011cvk.1_Missense_Mutation_p.R58C|C5orf13_uc011cvl.1_Missense_Mutation_p.R58C|C5orf13_uc011cvm.1_Missense_Mutation_p.R58C|C5orf13_uc011cvn.1_Missense_Mutation_p.R58C|C5orf13_uc011cvo.1_Missense_Mutation_p.R58C|C5orf13_uc011cvp.1_Missense_Mutation_p.R58C|C5orf13_uc011cvq.1_Missense_Mutation_p.R58C	NM_001142483	NP_001135955	Q16612	NP311_HUMAN	neuronal protein 3.1 isoform a	58						cytoplasm				skin(1)	1		all_cancers(142;0.00597)|all_epithelial(76;0.000144)|Prostate(80;0.0115)|Colorectal(10;0.0446)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;5.45e-09)|Epithelial(69;2e-08)|all cancers(49;1.9e-06)|COAD - Colon adenocarcinoma(37;0.0514)|Colorectal(14;0.0629)		CTTGGGGAGCGGAGTTCACTG	0.458													26	82					0	0	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778900	140778900	+	Silent	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140778900A>T	uc003lkf.1	+	1	1206	c.1206A>T	c.(1204-1206)ACA>ACT	p.T402T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.T402T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	402	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGGTAACAGATGGAACCC	0.478													9	45					0	0	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799566	140799566	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140799566C>T	uc003lkn.1	+	1	2285	c.2140C>T	c.(2140-2142)CGC>TGC	p.R714C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.R714C|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	714	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATTGCTCTACGCCTGCGACA	0.552													26	54					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140810887	140810887	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140810887C>T	uc003lkt.1	+	1	730	c.561C>T	c.(559-561)GAC>GAT	p.D187D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.D187D	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	187	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGAGCCGACGGTAGTAAGT	0.607													9	132					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160033923	160033923	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:160033923C>T	uc003lym.1	-	19	3856	c.3009G>A	c.(3007-3009)TTG>TTA	p.L1003L	ATP10B_uc010jit.1_Silent_p.L320L	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1003	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGGCATTCAATGTCTTCC	0.512													5	111					0	0	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313527	1313527	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:1313527C>G	uc003mtl.3	+	1	853	c.588C>G	c.(586-588)CTC>CTG	p.L196L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	196	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ACTGGATGCTCAACCCCAACA	0.547													3	62					0	0	0	0
SIRT5	23408	broad.mit.edu	37	6	13601120	13601120	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:13601120G>T	uc003nay.2	+	9	1092	c.796G>T	c.(796-798)GCC>TCC	p.A266S	SIRT5_uc003naw.2_Missense_Mutation_p.A266S|SIRT5_uc003nax.2_Missense_Mutation_p.A158S|SIRT5_uc011dit.1_Missense_Mutation_p.A248S	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	266	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CCAGGTGGCTGCCAGGGGCGT	0.577													7	39					0.000274275	0.000294885	1	0
RBM24	221662	broad.mit.edu	37	6	17291995	17291995	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:17291995C>T	uc003nbz.3	+	4	360	c.356C>T	c.(355-357)GCC>GTC	p.A119V	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.A61V|RBM24_uc003nca.2_Missense_Mutation_p.A74V|RBM24_uc011diy.1_Missense_Mutation_p.P33S|RBM24_uc011diz.1_Missense_Mutation_p.P18S	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	119					cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			AGGATACCTGCCCACTATGTC	0.483													26	162					0	0	0	0
ETV7	51513	broad.mit.edu	37	6	36334462	36334462	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:36334462C>T	uc003omb.2	-	8	1135	c.986G>A	c.(985-987)AGA>AAA	p.R329K	ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Missense_Mutation_p.R274K|ETV7_uc010jwj.2_Missense_Mutation_p.R270K|ETV7_uc010jwh.2_Missense_Mutation_p.R248K|ETV7_uc010jwi.2_Missense_Mutation_p.R252K|ETV7_uc011dtl.1_Missense_Mutation_p.R178K	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	329					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GAACTCTATTCTGTCCTGCTC	0.577													6	149					0	0	0	0
UTRN	7402	broad.mit.edu	37	6	145103095	145103095	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:145103095C>G	uc003qkt.2	+	60	8762	c.8670C>G	c.(8668-8670)TTC>TTG	p.F2890L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2890	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGAAATTTTCAAACAGCACA	0.338													4	37					0	0	0	0
RGS17	26575	broad.mit.edu	37	6	153347617	153347617	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:153347617T>G	uc003qpm.2	-	3	337	c.181A>C	c.(181-183)ATG>CTG	p.M61L		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	61					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		ATACTCTCCATTTTTGTAGTG	0.413									Lung_Cancer_Familial_Clustering_of				31	79					0	0	0	0
SERAC1	84947	broad.mit.edu	37	6	158565392	158565392	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:158565392C>T	uc003qrc.2	-	7	690	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	183					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTCTTCGCTTCGTGCCAAACC	0.338													4	47					0	0	0	0
THBS2	7058	broad.mit.edu	37	6	169648845	169648845	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:169648845C>G	uc003qwt.2	-	4	524	c.276G>C	c.(274-276)CAG>CAC	p.Q92H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	92	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ACTTGCCGTCCTGCTTGAGCT	0.622													8	65					0	0	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6085734	6085734	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:6085734T>A	uc003spp.2	-	6	744	c.598A>T	c.(598-600)ATT>TTT	p.I200F	EIF2AK1_uc003spq.2_Missense_Mutation_p.I200F|EIF2AK1_uc011jwm.1_Missense_Mutation_p.I76F|EIF2AK1_uc003spr.1_5'UTR	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	200	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GCACCCTTAATCAGGATTTTT	0.254													5	21					0	0	0	0
TMEM195	392636	broad.mit.edu	37	7	15240926	15240926	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:15240926G>C	uc003stb.1	-	13	1492	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	441					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CCAAGGGTGAGAGGTGAGTTG	0.308													8	47					0	0	0	0
CACNA2D1	781	broad.mit.edu	37	7	81714097	81714097	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:81714097G>A	uc003uhr.1	-	7	902	c.646C>T	c.(646-648)CGA>TGA	p.R216*		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	216	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GGATAATATCGAGCTAGGCCA	0.423													13	45					0	0	0	0
TMEM130	222865	broad.mit.edu	37	7	98446224	98446224	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:98446224C>T	uc003upo.2	-	7	1290	c.1101G>A	c.(1099-1101)CAG>CAA	p.Q367Q	TMEM130_uc011kiq.1_Silent_p.Q348Q|TMEM130_uc011kir.1_Silent_p.Q367Q|TMEM130_uc003upn.2_Silent_p.Q265Q	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	367	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGTCCTTTTGCTGAGTGGCAT	0.557													13	67					0	0	0	0
PTCD1	26024	broad.mit.edu	37	7	99027337	99027337	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:99027337C>G	uc003uqh.2	-	4	818	c.687G>C	c.(685-687)CAG>CAC	p.Q229H	PTCD1_uc011kiw.1_Missense_Mutation_p.Q278H	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	229	PPR 3.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGGGCGCTCTGTAGAGCTG	0.597													4	63					0	0	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99654858	99654858	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:99654858G>A	uc003uso.2	+	2	373	c.229G>A	c.(229-231)GAG>AAG	p.E77K	ZSCAN21_uc011kje.1_Missense_Mutation_p.E76K|ZSCAN21_uc003usn.1_Missense_Mutation_p.E76K	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	77	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GCTGAGGCCCGAGATCCACAC	0.637													5	40					0	0	0	0
EPO	2056	broad.mit.edu	37	7	100320365	100320365	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:100320365G>C	uc003uwi.2	+	4	506	c.325G>C	c.(325-327)GTC>CTC	p.V109L	EPO_uc011kkc.1_Missense_Mutation_p.V109L	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	109					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GGCCCTGTTGGTCAACTCTTC	0.657													3	61					0	0	0	0
CUX1	1523	broad.mit.edu	37	7	101838850	101838850	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:101838850G>A	uc003uyx.3	+	14	1227	c.1189G>A	c.(1189-1191)GCC>ACC	p.A397T	CUX1_uc003uys.3_Missense_Mutation_p.A408T|CUX1_uc003uyt.2_Missense_Mutation_p.A408T|CUX1_uc011kkn.1_Missense_Mutation_p.A369T|CUX1_uc003uyw.2_Missense_Mutation_p.A362T|CUX1_uc003uyv.2_Missense_Mutation_p.A392T|CUX1_uc003uyu.2_Missense_Mutation_p.A406T	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	397					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GTCCGAGAACGCCGCGCTGCG	0.682													6	33					0	0	0	0
FEZF1	389549	broad.mit.edu	37	7	121942917	121942917	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:121942917G>A	uc003vkd.2	-	3	1079	c.1005C>T	c.(1003-1005)ACC>ACT	p.T335T	FEZF1_uc003vkc.2_Silent_p.T285T|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	335	C2H2-type 3.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CGTGTATTCGGGTATGAGTGT	0.408													26	62					0	0	0	0
ZNF786	136051	broad.mit.edu	37	7	148777738	148777738	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:148777738C>G	uc003wfh.2	-	2	227	c.90G>C	c.(88-90)CAG>CAC	p.Q30H	ZNF786_uc011kuk.1_5'UTR|ZNF786_uc003wfi.2_Intron	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			AAAGTTCCTTCTGCCATGCCT	0.428													3	55					0	0	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11188846	11188846	+	Silent	SNP	C	T	T	rs148317481		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:11188846C>T	uc003wtp.1	+	1	352	c.231C>T	c.(229-231)TGC>TGT	p.C77C		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	77	DUF6 1.|Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TCTGTCGATGCCTCTTCCACC	0.627													29	246					0	0	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38148029	38148029	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:38148029C>T	uc003xli.2	-	17	3600	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	WHSC1L1_uc011lbm.1_Missense_Mutation_p.E1028K|WHSC1L1_uc010lwe.2_Missense_Mutation_p.E979K	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1028					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GTCTGCCCTTCAGCAAAGCTT	0.443			T	NUP98	AML								8	171					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618162	77618162	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:77618162C>T	uc003yav.2	+	2	2226	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	ZFHX4_uc003yat.1_Silent_p.I613I|ZFHX4_uc003yau.1_Silent_p.I613I|ZFHX4_uc003yaw.1_Silent_p.I613I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	613	C2H2-type 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGTGGCATCGAGTGTCCAA	0.557										HNSCC(33;0.089)			6	80					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95547110	95547110	+	Silent	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:95547110T>G	uc003ygo.1	-	5	454	c.441A>C	c.(439-441)CCA>CCC	p.P147P	KIAA1429_uc003ygp.2_Silent_p.P147P	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	147	Pro-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GCTGGGGAggtggtggcggtg	0.323													5	31					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100832288	100832288	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:100832288G>C	uc003yiv.2	+	49	9118	c.9007G>C	c.(9007-9009)GAA>CAA	p.E3003Q	VPS13B_uc003yiw.2_Missense_Mutation_p.E2978Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3003					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGGCTATTTGAAGGAGAGAA	0.378													4	105					0	0	0	0
RNF139	11236	broad.mit.edu	37	8	125498991	125498991	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:125498991C>T	uc003yrc.2	+	2	1444	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	367	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCATTTTATCCATGGAATGA	0.423									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				19	202					0	0	0	0
BAI1	575	broad.mit.edu	37	8	143569790	143569790	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:143569790C>T	uc003ywm.2	+	13	2557	c.2374C>T	c.(2374-2376)CGG>TGG	p.R792W		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	792	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAAGGGCTGGCGGGCCACGGG	0.632													5	119					0	0	0	0
TESK1	7016	broad.mit.edu	37	9	35609464	35609464	+	Silent	SNP	C	A	A	rs142237307	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:35609464C>A	uc003zxa.2	+	10	1942	c.1606C>A	c.(1606-1608)CGG>AGG	p.R536R	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Silent_p.R376R	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	536					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCCTGGAACCGGGCCCAGCA	0.687													18	28					1.67942e-08	1.92822e-08	1	0
TRPM3	80036	broad.mit.edu	37	9	73164531	73164531	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:73164531C>G	uc004aid.2	-	24	3842	c.3598G>C	c.(3598-3600)GAA>CAA	p.E1200Q	TRPM3_uc004ahu.2_Missense_Mutation_p.E1042Q|TRPM3_uc004ahv.2_Missense_Mutation_p.E1002Q|TRPM3_uc004ahw.2_Missense_Mutation_p.E1072Q|TRPM3_uc004ahx.2_Missense_Mutation_p.E1059Q|TRPM3_uc004ahy.2_Missense_Mutation_p.E1062Q|TRPM3_uc004ahz.2_Missense_Mutation_p.E1049Q|TRPM3_uc004aia.2_Missense_Mutation_p.E1047Q|TRPM3_uc004aib.2_Missense_Mutation_p.E1037Q|TRPM3_uc004aic.2_Missense_Mutation_p.E1200Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1225	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAGTATTCTTCTATGCATTGC	0.413													3	71					0	0	0	0
SURF1	6834	broad.mit.edu	37	9	136220669	136220669	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:136220669G>A	uc004cdh.1	-	5	482	c.450C>T	c.(448-450)GGC>GGT	p.G150G	SURF1_uc004cdg.1_Silent_p.G41G|SURF2_uc004cdi.2_5'Flank	NM_003172	NP_003163	Q15526	SURF1_HUMAN	surfeit 1	150					aerobic respiration|respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			breast(2)	2				OV - Ovarian serous cystadenocarcinoma(145;5.06e-07)|Epithelial(140;4.25e-06)|all cancers(34;3.93e-05)		AGGAGATGAGGCCGCCCTCCC	0.617													8	176					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139399790	139399790	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139399790C>G	uc004chz.2	-	25	4558	c.4558G>C	c.(4558-4560)GAC>CAC	p.D1520H	NOTCH1_uc004cia.1_Missense_Mutation_p.D750H	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1520	Extracellular (Potential).|LNR 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGCTGGCAGTCAAAGCCGTCG	0.627			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			2	6					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412284	139412284	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139412284T>G	uc004chz.2	-	8	1361	c.1361A>C	c.(1360-1362)AAC>ACC	p.N454T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	454	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GACGCACTCGTTGACGTCGAT	0.657			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			11	84					0	0	0	0
CACNA1B	774	broad.mit.edu	37	9	140991032	140991032	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:140991032C>T	uc004cog.2	+	36	5336	c.5191C>T	c.(5191-5193)CGG>TGG	p.R1731W	CACNA1B_uc004coi.2_Missense_Mutation_p.R943W|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1731	EF-hand.|Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGAGTTCATCCGGGTCTGGGC	0.562													37	47					0	0	0	0
RBBP7	5931	broad.mit.edu	37	X	16863980	16863980	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:16863980C>G	uc004cxt.2	-	11	1538	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q	RBBP7_uc004cxs.1_Missense_Mutation_p.E438Q|RBBP7_uc004cxu.2_Missense_Mutation_p.E385Q	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	394	WD 7.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					ATGTTATCCTCAGACACTGAG	0.353													4	45					0	0	0	0
RAI2	10742	broad.mit.edu	37	X	17819471	17819471	+	Silent	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:17819471G>T	uc004cyf.2	-	3	1230	c.660C>A	c.(658-660)CCC>CCA	p.P220P	RAI2_uc004cyg.2_Silent_p.P220P|RAI2_uc010nfa.2_Silent_p.P220P|RAI2_uc004cyh.3_Silent_p.P220P|RAI2_uc011miy.1_Silent_p.P170P	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	220	Pro-rich.				embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GGGGGGACAAGGGGGAGCTAA	0.632													24	35					6.44725e-10	7.44838e-10	1	0
FAM47B	170062	broad.mit.edu	37	X	34961653	34961653	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:34961653C>T	uc004ddi.1	+	1	723	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	235	Pro-rich.									ovary(3)|breast(1)	4						TGTCCAGTCTCCACCCGGAAC	0.637													6	105					0	0	0	0
MIR222	407007	broad.mit.edu	37	X	45606471	45606471	+	RNA	SNP	C	T	T	rs72631825		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:45606471C>T	hsa-mir-222|MI0000299	-			c.60C>T			uc011mle.1_5'Flank|MIR221_hsa-mir-221|MI0000298_5'Flank|uc011mlf.1_RNA																	0						CTGCTGATTACGAAAGACAGG	0.493													5	24					0	0	0	0
OGT	8473	broad.mit.edu	37	X	70787880	70787880	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:70787880C>T	uc004eaa.1	+	21	3097	c.2880C>T	c.(2878-2880)CTC>CTT	p.L960L	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.L950L|OGT_uc004eac.2_Silent_p.L821L|OGT_uc004ead.2_Silent_p.L579L	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	960					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					CATCCCAGCTCACTTGCTTAG	0.383													16	110					0	0	0	0
HDX	139324	broad.mit.edu	37	X	83723803	83723803	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:83723803C>T	uc004eek.1	-	3	1037	c.928G>A	c.(928-930)GAG>AAG	p.E310K	HDX_uc011mqv.1_Missense_Mutation_p.E310K|HDX_uc004eel.1_Missense_Mutation_p.E252K	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	310						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						AGCTCTTCCTCTCTGGCATAT	0.473													16	80					0	0	0	0
GLA	2717	broad.mit.edu	37	X	100662806	100662806	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:100662806G>A	uc004ehl.1	-	1	196	c.86C>T	c.(85-87)GCT>GTT	p.A29V	HNRNPH2_uc004ehm.2_5'Flank|HNRNPH2_uc004ehn.2_5'Flank|GLA_uc011mrj.1_Missense_Mutation_p.A29V	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	29					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	CAGTGCTCTAGCCCCAGGGAT	0.602													5	137					0	0	0	0
CUL4B	8450	broad.mit.edu	37	X	119660660	119660660	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:119660660C>T	uc004esw.2	-	22	3135	c.2698G>A	c.(2698-2700)GAA>AAA	p.E900K	CUL4B_uc010nqq.2_Missense_Mutation_p.E601K|CUL4B_uc004esv.2_Missense_Mutation_p.E882K	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	900					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTATCTCTTTCCATGTAGTCC	0.373													26	56					0	0	0	0
CT47B1	643311	broad.mit.edu	37	X	120007815	120007815	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:120007815C>A	uc011muc.1	-	2	1090	c.835G>T	c.(835-837)GAA>TAA	p.E279*		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	279	Potential.										0						TCTTTCTCTTCCTCGCCTGCA	0.458													155	488					4.69383e-74	5.52565e-74	1	0
THOC2	57187	broad.mit.edu	37	X	122820424	122820424	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:122820424G>C	uc004etu.2	-	8	774	c.742C>G	c.(742-744)CTT>GTT	p.L248V	THOC2_uc011muh.1_Missense_Mutation_p.L169V|THOC2_uc011mui.1_Missense_Mutation_p.L133V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	248					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTGAACCCAAGAATATGACAC	0.299													6	49					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135429169	135429169	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:135429169G>T	uc004ezu.1	+	6	3595	c.3304G>T	c.(3304-3306)GCA>TCA	p.A1102S	GPR112_uc010nsb.1_Missense_Mutation_p.A897S|GPR112_uc010nsc.1_Missense_Mutation_p.A869S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1102	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GACATCCATGGCAGTTCCTTC	0.478													11	212					1.33987e-11	1.5576e-11	1	0
SOX3	6658	broad.mit.edu	37	X	139586097	139586097	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:139586097C>G	uc004fbd.1	-	1	1129	c.1129G>C	c.(1129-1131)GAG>CAG	p.E377Q		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	377					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GAGCTGGGCTCAGACTTCACT	0.473													4	16					0	0	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870209	151870209	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:151870209C>A	uc004ffq.1	+	3	1093	c.899C>A	c.(898-900)TCC>TAC	p.S300Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.S300Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	300	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCGCATTTCCTACCCACTC	0.562													7	227					5.18039e-06	5.83971e-06	1	0
ATP2B3	492	broad.mit.edu	37	X	152821580	152821580	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:152821580C>T	uc004fht.1	+	12	2258	c.2132C>T	c.(2131-2133)ACG>ATG	p.T711M	ATP2B3_uc004fhs.1_Missense_Mutation_p.T711M	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	711	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AACATCAACACGGCCCGGGCC	0.592													26	99					0	0	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6534542	6534542	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:6534542G>A	uc001ano.1	-	7	677	c.576C>T	c.(574-576)TAC>TAT	p.Y192Y	PLEKHG5_uc001ann.1_Silent_p.Y173Y|PLEKHG5_uc001anq.1_Silent_p.Y213Y|PLEKHG5_uc001anp.1_Silent_p.Y213Y|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Silent_p.Y205Y|PLEKHG5_uc001ank.1_Silent_p.Y136Y|PLEKHG5_uc009vmb.1_Silent_p.Y136Y|PLEKHG5_uc001anl.1_Silent_p.Y136Y|PLEKHG5_uc001anm.1_Silent_p.Y136Y	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	192					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCCCGAACCTGTAGGCCTCGA	0.607000													6	29					0	0	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930414	53930414	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:53930414G>A	uc001cvq.1	+	3	910	c.855G>A	c.(853-855)CCG>CCA	p.P285P		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	285	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AGTTCCTCCCGCCAGGCTACC	0.522000													13	73					0	0	0	0
C1orf168	199920	broad.mit.edu	37	1	57257877	57257877	+	Silent	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:57257877G>T	uc001cym.3	-	2	1015	c.609C>A	c.(607-609)CCC>CCA	p.P203P	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.P203P	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	203										ovary(3)|skin(2)	5						GTAATATTTTGGGGGCCACCA	0.488000													9	123					2.17888e-05	2.38729e-05	1	0
PTGFR	5737	broad.mit.edu	37	1	79002110	79002110	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:79002110G>A	uc001din.2	+	3	1084	c.818G>A	c.(817-819)GGA>GAA	p.G273E	PTGFR_uc001dim.2_Missense_Mutation_p.E297K	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	273	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GCCAACATTGGAATAAATGGA	0.343000													4	56					0	0	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020169	156020169	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:156020169C>T	uc001fna.2	-	4	678	c.654G>A	c.(652-654)ATG>ATA	p.M218I	UBQLN4_uc010pgx.1_Missense_Mutation_p.M198I	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	218						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGGCCATAATCATGTGACGCA	0.522000													6	137					0	0	0	0
DDX59	83479	broad.mit.edu	37	1	200619738	200619738	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:200619738C>G	uc009wzk.2	-	5	1372	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	DDX59_uc010ppl.1_Missense_Mutation_p.D377H	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	377	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GTCTGACAATCATTAGGAATG	0.353000													3	39					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224880	248224880	+	Silent	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:248224880C>A	uc001idx.1	+	1	897	c.897C>A	c.(895-897)GCC>GCA	p.A299A	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGATGGGGGCCCTGACACGAG	0.493000													10	58					0.00621372	0.0065244	1	0
OR2M3	127062	broad.mit.edu	37	1	248366774	248366774	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:248366774C>G	uc010pzg.1	+	1	405	c.405C>G	c.(403-405)CTC>CTG	p.L135L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACACCAATCTCATGAGCCCTA	0.438000													13	247					0	0	0	0
SEC61A2	55176	broad.mit.edu	37	10	12197794	12197794	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr10:12197794G>A	uc001ile.2	+	7	627	c.480G>A	c.(478-480)TTG>TTA	p.L160L	SEC61A2_uc010qbq.1_Silent_p.L138L|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Silent_p.L160L	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	160	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				TTGCTGGTTTGATTGTGCTGC	0.473000													34	303					0	0	0	0
ACBD5	91452	broad.mit.edu	37	10	27512312	27512312	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr10:27512312T>A	uc010qdp.1	-	5	636	c.445A>T	c.(445-447)ATT>TTT	p.I149F	ACBD5_uc010qdm.1_Missense_Mutation_p.I147F|ACBD5_uc010qdn.1_Missense_Mutation_p.I40F|ACBD5_uc010qdo.1_Missense_Mutation_p.I40F|ACBD5_uc001ito.2_Missense_Mutation_p.I114F|ACBD5_uc001itp.2_Missense_Mutation_p.I40F|ACBD5_uc001itq.2_Missense_Mutation_p.I40F|ACBD5_uc001itr.1_5'UTR	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	147					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						TCCTCGACAATTTCATAAAAT	0.318000													3	51					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123970684	123970684	+	Silent	SNP	G	A	A	rs35532970		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr10:123970684G>A	uc001lfv.2	+	9	7104	c.6744G>A	c.(6742-6744)TCG>TCA	p.S2248S	TACC2_uc001lfw.2_Silent_p.S394S|TACC2_uc009xzx.2_Silent_p.S2203S|TACC2_uc010qtv.1_Silent_p.S2252S|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Silent_p.S326S|TACC2_uc001lga.2_Silent_p.S326S|TACC2_uc009xzy.2_Silent_p.S326S|TACC2_uc001lgb.2_Silent_p.S283S|TACC2_uc010qtw.1_Silent_p.S343S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2248						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TAACCCCATCGGATAGCGGGG	0.602000													5	55					0	0	0	0
CUZD1	50624	broad.mit.edu	37	10	124598737	124598737	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr10:124598737C>T	uc001lgq.2	-	3	576	c.244G>A	c.(244-246)GAT>AAT	p.D82N	CUZD1_uc001lgp.2_5'Flank|CUZD1_uc009yad.2_5'Flank|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.D82N|CUZD1_uc010qtz.1_Missense_Mutation_p.D82N	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	82	CUB 1.|Extracellular (Potential).				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CAGCTTCCATCTGGATCAAGC	0.453000													7	107					0	0	0	0
NLRP6	171389	broad.mit.edu	37	11	281225	281225	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr11:281225C>G	uc010qvs.1	+	4	1491	c.1491C>G	c.(1489-1491)TTC>TTG	p.F497L	NLRP6_uc010qvt.1_Missense_Mutation_p.F497L	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	497	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTACCAGTTCATCGACCAGA	0.627000													5	122					0	0	0	0
NUP98	4928	broad.mit.edu	37	11	3727721	3727721	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr11:3727721G>C	uc001lyh.2	-	21	3170	c.2879C>G	c.(2878-2880)TCA>TGA	p.S960*	NUP98_uc001lyi.2_Nonsense_Mutation_p.S960*|NUP98_uc001lyg.2_Nonsense_Mutation_p.S28*	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	977					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AATATGTGTTGAGGCAGACAC	0.423000			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								4	127					0	0	0	0
LDHC	3948	broad.mit.edu	37	11	18467778	18467778	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr11:18467778G>A	uc001mon.3	+	7	844	c.732G>A	c.(730-732)CTG>CTA	p.L244L	LDHC_uc001mom.3_Silent_p.L244L|LDHC_uc009yhp.2_Intron|LDHC_uc001moo.3_Silent_p.L128L|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Intron	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	244					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TTATCAAGCTGAAGGGGTATA	0.373000													6	78					0	0	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110451310	110451310	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr11:110451310C>G	uc001pkz.1	-	16	2645	c.2360G>C	c.(2359-2361)GGA>GCA	p.G787A	ARHGAP20_uc001pky.1_Missense_Mutation_p.G764A|ARHGAP20_uc009yyb.1_Missense_Mutation_p.G751A|ARHGAP20_uc001pla.1_Missense_Mutation_p.G751A|ARHGAP20_uc001plb.2_Missense_Mutation_p.G330A	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	787					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CACGTGATTTCCTTCACTACC	0.413000													5	97					0	0	0	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612000													3	15					0	0	0	0
FAR2	55711	broad.mit.edu	37	12	29486610	29486610	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:29486610C>T	uc001ris.3	+	12	1578	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	FAR2_uc001rit.2_Silent_p.I477I|FAR2_uc009zjm.2_Silent_p.I380I	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	477	Helical; (Potential).				ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TCTTCCTTATCGCCTGGCGCC	0.428000													12	185					0	0	0	0
SOAT2	8435	broad.mit.edu	37	12	53509201	53509201	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:53509201C>T	uc001sbv.2	+	6	559	c.471C>T	c.(469-471)ATC>ATT	p.I157I	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	157	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						ACCTACTGATCTTCAGCTTCG	0.552000													3	42					0	0	0	0
METTL7B	196410	broad.mit.edu	37	12	56075775	56075775	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:56075775C>T	uc010spr.1	+	1	446	c.237C>T	c.(235-237)TGC>TGT	p.C79C		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	79							methyltransferase activity				0						AGCTGGGCTGCGGAACCGGAG	0.572000													9	29					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109684111	109684111	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:109684111A>G	uc001tob.2	+	39	5548	c.5429A>G	c.(5428-5430)TAC>TGC	p.Y1810C	ACACB_uc001toc.2_Missense_Mutation_p.Y1810C|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.Y476C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1810	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GACCTTCTGTACCTGCGGGCA	0.562000													4	107					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120166409	120166409	+	Silent	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr12:120166409G>C	uc001txi.1	-	27	3416	c.3363C>G	c.(3361-3363)CTC>CTG	p.L1121L	CIT_uc001txh.1_Silent_p.L655L|CIT_uc001txj.1_Silent_p.L1163L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1121	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCAGGTCATTGAGCTAGACAT	0.438000													7	143					0	0	0	0
LNX2	222484	broad.mit.edu	37	13	28136648	28136648	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr13:28136648C>A	uc001url.3	-	5	1435	c.1126G>T	c.(1126-1128)GCC>TCC	p.A376S	LNX2_uc001urm.1_Missense_Mutation_p.A376S	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	376	PDZ 2.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CCGTCCTGGGCAGCCAACCCC	0.532000													20	150					1.1804e-14	1.33991e-14	1	0
FLT3	2322	broad.mit.edu	37	13	28609671	28609671	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr13:28609671G>C	uc001urw.2	-	12	1640	c.1558C>G	c.(1558-1560)CTT>GTT	p.L520V	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L520V	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	520	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GATGTGCCAAGGGAATTGTAT	0.453000			Mis|O		AML|ALL								5	84					0	0	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559752	46559752	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr13:46559752C>T	uc010tfw.1	-	9	1406	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q	ZC3H13_uc001vas.1_Missense_Mutation_p.R467Q|ZC3H13_uc001vat.1_Missense_Mutation_p.R467Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	467	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TAGTTCCCTTCGGTCCCTAGT	0.507000													12	181					0	0	0	0
FAM10A4	145165	broad.mit.edu	37	13	50746753	50746753	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr13:50746753T>G	uc001vej.2	+	1	600	c.529T>G	c.(529-531)TCA>GCA	p.S177A	DLEU1_uc010adl.1_Intron|DLEU1_uc001vee.1_Intron|DLEU1_uc010adm.1_Intron|DLEU1_uc010adn.1_Intron|DLEU1_uc001vef.1_Intron|DLEU1_uc001veg.1_Intron|DLEU1_uc010tgn.1_Intron|DLEU1_uc001vei.1_Intron|DLEU1_uc010ado.1_Intron|DLEU1_uc010adp.1_Intron	NR_002183				SubName: Full=ST13 protein;												0						AAATCCTGATTCAGCTCAGCC	0.488000													9	152					0	0	0	0
COCH	1690	broad.mit.edu	37	14	31358870	31358870	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr14:31358870T>G	uc001wqr.2	+	12	1606	c.1526T>G	c.(1525-1527)CTG>CGG	p.L509R	COCH_uc001wqp.2_Missense_Mutation_p.L509R|COCH_uc001wqq.3_Intron|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.L360R	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	509	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CTGGATGACCTGAAAGATATG	0.388000													7	39					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44975153	44975153	+	Silent	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr14:44975153A>T	uc001wvn.2	-	1	1347	c.1038T>A	c.(1036-1038)CTT>CTA	p.L346L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	346	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTTCAGCCAGAAGCTCTACAG	0.507000													13	111					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411954	105411954	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr14:105411954G>A	uc010axc.1	-	7	9954	c.9834C>T	c.(9832-9834)GTC>GTT	p.V3278V	AHNAK2_uc001ypx.2_Silent_p.V3178V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3278						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGCCTCGACGTCCACCT	0.607000													30	234					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85163919	85163919	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr15:85163919G>C	uc002bkr.2	+	3	719	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ZSCAN2_uc010bmz.1_Missense_Mutation_p.E163Q|ZSCAN2_uc010bna.2_Missense_Mutation_p.E15Q|ZSCAN2_uc010uox.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoy.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoz.1_Missense_Mutation_p.E164Q	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	165					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GGAAATGCCTGAAGGTGAAAG	0.473000													6	119					0	0	0	0
IQGAP1	8826	broad.mit.edu	37	15	91020962	91020962	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr15:91020962G>C	uc002bpl.1	+	26	3271	c.3170G>C	c.(3169-3171)AGT>ACT	p.S1057T		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1057	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ATGGTTGTAAGTTTCAACCGT	0.408000													5	55					0	0	0	0
NDUFB10	4716	broad.mit.edu	37	16	2011519	2011519	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr16:2011519C>G	uc002cni.2	+	3	400	c.291C>G	c.(289-291)ATC>ATG	p.I97M	NDUFB10_uc002cnj.2_Missense_Mutation_p.I97M	NM_004548	NP_004539	O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	97					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	AAGAAATTATCAACATTATGC	0.473000													6	192					0	0	0	0
RBBP6	5930	broad.mit.edu	37	16	24552017	24552017	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr16:24552017A>G	uc002dmh.2	+	1	1110	c.70A>G	c.(70-72)ATC>GTC	p.I24V	RBBP6_uc010vcb.1_Intron|RBBP6_uc002dmg.2_Missense_Mutation_p.I24V|RBBP6_uc002dmi.2_Missense_Mutation_p.I24V|RBBP6_uc010bxr.2_Missense_Mutation_p.I24V	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	24	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TGGGCTCCACATCTCCCTCTG	0.483000													14	59					0	0	0	0
ZNF48	197407	broad.mit.edu	37	16	30410135	30410135	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr16:30410135G>T	uc002dya.1	+	2	1623	c.1564G>T	c.(1564-1566)GGC>TGC	p.G522C	ZNF48_uc002dxz.1_Missense_Mutation_p.G399C	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	522	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAACCCACCTGGCCCAGTACC	0.677000													5	110					0.00116845	0.00123718	1	0
NLRC5	84166	broad.mit.edu	37	16	57101666	57101666	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr16:57101666C>T	uc002ekk.1	+	36	4650	c.4425C>T	c.(4423-4425)CTC>CTT	p.L1475L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Silent_p.L17L|NLRC5_uc002ekr.1_Silent_p.L362L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1475	LRR 15.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGTTAACCTCTGTGAGGACG	0.507000													5	79					0	0	0	0
MYO1C	4641	broad.mit.edu	37	17	1387008	1387008	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:1387008G>A	uc002fsp.2	-	3	463	c.243C>T	c.(241-243)GGC>GGT	p.G81G	MYO1C_uc002fsn.2_Silent_p.G62G|MYO1C_uc002fso.2_Silent_p.G46G|MYO1C_uc010vqj.1_Silent_p.G46G|MYO1C_uc010vqk.1_Silent_p.G57G	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	81	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCAGGACGGGGCCAATGTAGG	0.433000													3	16					0	0	0	0
PRPF8	10594	broad.mit.edu	37	17	1562841	1562841	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:1562841C>A	uc002fte.2	-	32	5062	c.4948G>T	c.(4948-4950)GAT>TAT	p.D1650Y		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1650						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCCATCACATCCCTGAGGATG	0.527000													9	78					0.000274275	0.00029287	1	0
MYOCD	93649	broad.mit.edu	37	17	12666526	12666526	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:12666526C>G	uc002gnn.2	+	13	2681	c.2382C>G	c.(2380-2382)ATC>ATG	p.I794M	MYOCD_uc002gno.2_Missense_Mutation_p.I842M|MYOCD_uc002gnq.2_Missense_Mutation_p.I518M	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	794					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCAGCCAGATCCCCTTTGATC	0.483000													6	110					0	0	0	0
SREBF1	6720	broad.mit.edu	37	17	17718569	17718569	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:17718569G>A	uc002gru.1	-	13	2652	c.2458C>T	c.(2458-2460)CCC>TCC	p.P820S	SREBF1_uc002grp.1_Missense_Mutation_p.P439S|SREBF1_uc002grq.1_Missense_Mutation_p.P339S|SREBF1_uc002grr.1_Missense_Mutation_p.P566S|SREBF1_uc002grs.1_Missense_Mutation_p.P796S|SREBF1_uc002grt.1_Missense_Mutation_p.P850S|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	820	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CTGGGGTTGGGCTGGGTCACA	0.617000													8	104					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18040913	18040913	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:18040913A>G	uc010vxh.1	+	15	5133	c.4795A>G	c.(4795-4797)AGC>GGC	p.S1599G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1599	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GAGCTTCAACAGCTTTGAGCA	0.532000													5	56					0	0	0	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542000													4	72					0	0	0	0
KIAA0100	9703	broad.mit.edu	37	17	26948139	26948139	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:26948139G>A	uc002hbu.2	-	28	5208	c.5109C>T	c.(5107-5109)ATC>ATT	p.I1703I	KIAA0100_uc002hbt.2_Silent_p.I32I	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1703						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AACGCGAAATGATCCGCTGGA	0.448000													4	64					0	0	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475597	42475597	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:42475597G>A	uc002igw.1	-	8	3912	c.3848C>T	c.(3847-3849)GCA>GTA	p.A1283V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1205V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1205V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1283						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACTGGGAGGTGCATAACTGGG	0.592000													7	177					0	0	0	0
DNAH17	8632	broad.mit.edu	37	17	76506502	76506502	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:76506502G>A	uc010wtu.1	-	1	252	c.75C>T	c.(73-75)ATC>ATT	p.I25I						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCTTGTCCACGATGTTGCGGA	0.532000													7	199					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57327549	57327549	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr19:57327549G>A	uc002qnu.2	-	7	2612	c.2261C>T	c.(2260-2262)TCT>TTT	p.S754F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.S725F|PEG3_uc002qnv.2_Missense_Mutation_p.S754F|PEG3_uc002qnw.2_Missense_Mutation_p.S630F|PEG3_uc002qnx.2_Missense_Mutation_p.S628F|PEG3_uc010etr.2_Missense_Mutation_p.S754F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	754					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAGGGGTTAGAGCTAATGGT	0.413000													10	164					0	0	0	0
GALNT14	79623	broad.mit.edu	37	2	31215732	31215732	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:31215732G>A	uc002rnr.2	-	2	890	c.271C>T	c.(271-273)CGG>TGG	p.R91W	GALNT14_uc002rnq.2_Missense_Mutation_p.R71W|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R56W|GALNT14_uc010ezo.1_Missense_Mutation_p.R91W|GALNT14_uc010ezp.1_Missense_Mutation_p.R62W	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	91	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGATGGCCCGATTGCTGGAG	0.562000													6	89					0	0	0	0
EFEMP1	2202	broad.mit.edu	37	2	56097911	56097911	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:56097911T>G	uc002rzh.2	-	10	1594	c.1264A>C	c.(1264-1266)ACC>CCC	p.T422P	EFEMP1_uc002rzi.2_Missense_Mutation_p.T422P|EFEMP1_uc002rzj.2_Missense_Mutation_p.T422P|EFEMP1_uc010ypc.1_Missense_Mutation_p.T284P	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	422	Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTATTGATGGTGTTGGCATAA	0.418000													3	58					0	0	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049988	69049988	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:69049988G>C	uc002seu.2	+	10	2078	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E573Q|ARHGAP25_uc010yql.1_Missense_Mutation_p.E533Q|ARHGAP25_uc002sew.2_Missense_Mutation_p.E565Q|ARHGAP25_uc002sex.2_Missense_Mutation_p.E566Q|ARHGAP25_uc002sey.2_Missense_Mutation_p.E299Q	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	572	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GCAAATGTATGAGGAACAGAT	0.448000													3	54					0	0	0	0
PCGF1	84759	broad.mit.edu	37	2	74733102	74733102	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:74733102C>T	uc002slz.2	-	5	533	c.507G>A	c.(505-507)TTG>TTA	p.L169L	LBX2_uc002slw.2_5'Flank|PCGF1_uc002sly.2_Silent_p.L86L	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	169					histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						GGCACAGGTTCAACTGCTCAT	0.577000													13	197					0	0	0	0
GGCX	2677	broad.mit.edu	37	2	85781368	85781368	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:85781368C>G	uc002sps.2	-	7	893	c.787G>C	c.(787-789)GAC>CAC	p.D263H	GGCX_uc010yss.1_Missense_Mutation_p.D102H|GGCX_uc010yst.1_Missense_Mutation_p.D206H	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	263	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	GCTGAGAGGTCAAGCAGCAGC	0.507000													6	183					0	0	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514726	113514726	+	Missense_Mutation	SNP	G	C	C	rs77207496	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:113514726G>C	uc002tie.2	-	4	301	c.222C>G	c.(220-222)ATC>ATG	p.I74M	CKAP2L_uc002tif.2_Translation_Start_Site|CKAP2L_uc010yxp.1_Translation_Start_Site|CKAP2L_uc010yxq.1_Translation_Start_Site	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	74						centrosome					0						GTTTAATGCTGATGGACCTTT	0.413000													7	183					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141250263	141250263	+	Splice_Site	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:141250263C>G	uc002tvj.1	-	57	10007	c.9035_splice	c.e57-1	p.D3012_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTTCTTCATCTAAACACCAA	0.338000										TSP Lung(27;0.18)			6	67					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443000			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			5	58					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61542619	61542619	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr20:61542619C>T	uc002ydr.1	-	3	610	c.346G>A	c.(346-348)GAA>AAA	p.E116K	DIDO1_uc002yds.1_Missense_Mutation_p.E116K|DIDO1_uc002ydt.1_Missense_Mutation_p.E116K|DIDO1_uc002ydu.1_Missense_Mutation_p.E116K|DIDO1_uc002ydv.1_Missense_Mutation_p.E116K|DIDO1_uc002ydw.1_Missense_Mutation_p.E116K|DIDO1_uc002ydx.1_Missense_Mutation_p.E116K|DIDO1_uc011aao.1_Missense_Mutation_p.E116K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	116					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAGCGCTTTCCACGCTGCCC	0.637000													6	41					0	0	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61914181	61914181	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr20:61914181T>G	uc002yem.2	+	9	807	c.695T>G	c.(694-696)TTT>TGT	p.F232C	ARFGAP1_uc011aas.1_Missense_Mutation_p.F179C|ARFGAP1_uc011aat.1_Missense_Mutation_p.F119C|ARFGAP1_uc002yel.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yen.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yeo.1_5'Flank	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	232					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GCTACAAAGTTTGGATCCCAA	0.507000													15	42					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10996103	10996103	+	RNA	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr21:10996103G>C	uc002yis.1	-	12		c.2083C>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCCTTGCCCAGTTCGACTTCT	0.408000													4	59					0	0	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19704465	19704465	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr21:19704465C>G	uc002ykw.2	-	14	1621	c.1590G>C	c.(1588-1590)CTG>CTC	p.L530L		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	530	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTGGCTCCCACAGCTCAAAAG	0.403000													4	56					0	0	0	0
CECR5	27440	broad.mit.edu	37	22	17629399	17629399	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr22:17629399C>T	uc002zmf.2	-	3	410	c.382G>A	c.(382-384)GAG>AAG	p.E128K	CECR5_uc002zme.2_5'UTR|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.E98K	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	128							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				TCATGGTACTCGGAGAAGAGC	0.557000													14	260					0	0	0	0
TGFBR2	7048	broad.mit.edu	37	3	30715720	30715720	+	Missense_Mutation	SNP	C	T	T	rs104893811		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr3:30715720C>T	uc003ceo.2	+	5	1760	c.1378C>T	c.(1378-1380)CGC>TGC	p.R460C	TGFBR2_uc003cen.2_Missense_Mutation_p.R485C	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	460	Protein kinase.|Cytoplasmic (Potential).		R -> C (in AAT3).|R -> H (in AAT3).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						AATGACATCTCGCTGTAATGC	0.458000													7	63					0	0	0	0
ATRIP	84126	broad.mit.edu	37	3	48488144	48488144	+	5'Flank	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr3:48488144C>G	uc003ctf.1	+						ATRIP_uc011bbj.1_5'UTR|ATRIP_uc003ctg.1_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1						DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCGGGGCACTCGCGGCGGAGG	0.746000								Other_conserved_DNA_damage_response_genes					3	23					0	0	0	0
ITIH4	3700	broad.mit.edu	37	3	52857598	52857598	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr3:52857598G>T	uc003dfz.2	-	11	1549	c.1513C>A	c.(1513-1515)CTC>ATC	p.L505I	ITIH4_uc011bel.1_Missense_Mutation_p.L235I|ITIH4_uc003dfy.2_Missense_Mutation_p.L369I|ITIH4_uc011bem.1_Missense_Mutation_p.L505I|ITIH4_uc011ben.1_Missense_Mutation_p.L505I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	505					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GTGGCTGTGAGCACATCAGGC	0.612000													8	22					0.000157383	0.000170951	1	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	rs121913273		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	50					0	0	0	0
ZBTB49	166793	broad.mit.edu	37	4	4314793	4314793	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr4:4314793G>A	uc003ghu.2	+	5	1503	c.1328G>A	c.(1327-1329)CGA>CAA	p.R443Q	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_Intron|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	443	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACTCACTTACGACGGCATTCT	0.408000													7	50					0	0	0	0
AFAP1	60312	broad.mit.edu	37	4	7873772	7873772	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr4:7873772G>C	uc003gkg.1	-	2	307	c.34C>G	c.(34-36)CTT>GTT	p.L12V	AFAP1_uc011bwk.1_Missense_Mutation_p.L12V	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	12						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						AGGAGTTCAAGAAAGAGACGA	0.383000													3	61					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187629100	187629100	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr4:187629100G>A	uc003izf.2	-	2	2070	c.1882C>T	c.(1882-1884)CGA>TGA	p.R628*	FAT1_uc010iso.1_Nonsense_Mutation_p.R628*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	628	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATTAGCGATCGCTTTAATGAC	0.403000										HNSCC(5;0.00058)			6	63					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630411	187630411	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr4:187630411G>A	uc003izf.2	-	2	759	c.571C>T	c.(571-573)CGA>TGA	p.R191*	FAT1_uc010iso.1_Nonsense_Mutation_p.R191*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	191	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATATCTGTTCGATCTTTAAAA	0.433000										HNSCC(5;0.00058)			13	115					0	0	0	0
MIER3	166968	broad.mit.edu	37	5	56234739	56234739	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:56234739C>G	uc003jrd.1	-	4	311	c.286G>C	c.(286-288)GAT>CAT	p.D96H	MIER3_uc003jqz.1_Missense_Mutation_p.D33H|MIER3_uc003jra.1_Missense_Mutation_p.D96H|MIER3_uc003jrb.1_5'UTR|MIER3_uc003jrc.1_Missense_Mutation_p.D101H	NM_152622	NP_689835	Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GGTAGTTCATCTGCCAGTTCA	0.393000													6	63					0	0	0	0
SERINC5	256987	broad.mit.edu	37	5	79473175	79473175	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:79473175C>T	uc003kgj.2	-	4	548	c.419G>A	c.(418-420)GGA>GAA	p.G140E	SERINC5_uc003kgk.2_Missense_Mutation_p.G140E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.G140E|SERINC5_uc011ctj.1_Missense_Mutation_p.G140E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	140	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GAAGAAAGCTCCTGAGCACAT	0.393000													6	58					0	0	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													3	18					0	0	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778900	140778900	+	Silent	SNP	A	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:140778900A>T	uc003lkf.1	+	1	1206	c.1206A>T	c.(1204-1206)ACA>ACT	p.T402T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.T402T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	402	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGGTAACAGATGGAACCC	0.478000													9	45					0	0	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799566	140799566	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:140799566C>T	uc003lkn.1	+	1	2285	c.2140C>T	c.(2140-2142)CGC>TGC	p.R714C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.R714C|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	714	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATTGCTCTACGCCTGCGACA	0.552000													26	54					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140810887	140810887	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:140810887C>T	uc003lkt.1	+	1	730	c.561C>T	c.(559-561)GAC>GAT	p.D187D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.D187D	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	187	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGAGCCGACGGTAGTAAGT	0.607000													9	132					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160033923	160033923	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:160033923C>T	uc003lym.1	-	19	3856	c.3009G>A	c.(3007-3009)TTG>TTA	p.L1003L	ATP10B_uc010jit.1_Silent_p.L320L	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1003	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGGCATTCAATGTCTTCC	0.512000													5	111					0	0	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313527	1313527	+	Silent	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:1313527C>G	uc003mtl.3	+	1	853	c.588C>G	c.(586-588)CTC>CTG	p.L196L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	196	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ACTGGATGCTCAACCCCAACA	0.547000													3	62					0	0	0	0
SIRT5	23408	broad.mit.edu	37	6	13601120	13601120	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:13601120G>T	uc003nay.2	+	9	1092	c.796G>T	c.(796-798)GCC>TCC	p.A266S	SIRT5_uc003naw.2_Missense_Mutation_p.A266S|SIRT5_uc003nax.2_Missense_Mutation_p.A158S|SIRT5_uc011dit.1_Missense_Mutation_p.A248S	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	266	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CCAGGTGGCTGCCAGGGGCGT	0.577000													7	39					0.000274275	0.00029287	1	0
ETV7	51513	broad.mit.edu	37	6	36334462	36334462	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:36334462C>T	uc003omb.2	-	8	1135	c.986G>A	c.(985-987)AGA>AAA	p.R329K	ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Missense_Mutation_p.R274K|ETV7_uc010jwj.2_Missense_Mutation_p.R270K|ETV7_uc010jwh.2_Missense_Mutation_p.R248K|ETV7_uc010jwi.2_Missense_Mutation_p.R252K|ETV7_uc011dtl.1_Missense_Mutation_p.R178K	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	329					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GAACTCTATTCTGTCCTGCTC	0.577000													6	149					0	0	0	0
UTRN	7402	broad.mit.edu	37	6	145103095	145103095	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:145103095C>G	uc003qkt.2	+	60	8762	c.8670C>G	c.(8668-8670)TTC>TTG	p.F2890L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2890	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGAAATTTTCAAACAGCACA	0.338000													4	37					0	0	0	0
SERAC1	84947	broad.mit.edu	37	6	158565392	158565392	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:158565392C>T	uc003qrc.2	-	7	690	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	183					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTCTTCGCTTCGTGCCAAACC	0.338000													4	47					0	0	0	0
THBS2	7058	broad.mit.edu	37	6	169648845	169648845	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:169648845C>G	uc003qwt.2	-	4	524	c.276G>C	c.(274-276)CAG>CAC	p.Q92H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	92	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ACTTGCCGTCCTGCTTGAGCT	0.622000													8	65					0	0	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6085734	6085734	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:6085734T>A	uc003spp.2	-	6	744	c.598A>T	c.(598-600)ATT>TTT	p.I200F	EIF2AK1_uc003spq.2_Missense_Mutation_p.I200F|EIF2AK1_uc011jwm.1_Missense_Mutation_p.I76F|EIF2AK1_uc003spr.1_5'UTR	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	200	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GCACCCTTAATCAGGATTTTT	0.254000													5	21					0	0	0	0
TMEM195	392636	broad.mit.edu	37	7	15240926	15240926	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:15240926G>C	uc003stb.1	-	13	1492	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	441					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CCAAGGGTGAGAGGTGAGTTG	0.308000													8	47					0	0	0	0
CACNA2D1	781	broad.mit.edu	37	7	81714097	81714097	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:81714097G>A	uc003uhr.1	-	7	902	c.646C>T	c.(646-648)CGA>TGA	p.R216*		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	216	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GGATAATATCGAGCTAGGCCA	0.423000													13	45					0	0	0	0
TMEM130	222865	broad.mit.edu	37	7	98446224	98446224	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:98446224C>T	uc003upo.2	-	7	1290	c.1101G>A	c.(1099-1101)CAG>CAA	p.Q367Q	TMEM130_uc011kiq.1_Silent_p.Q348Q|TMEM130_uc011kir.1_Silent_p.Q367Q|TMEM130_uc003upn.2_Silent_p.Q265Q	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	367	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGTCCTTTTGCTGAGTGGCAT	0.557000													13	67					0	0	0	0
PTCD1	26024	broad.mit.edu	37	7	99027337	99027337	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:99027337C>G	uc003uqh.2	-	4	818	c.687G>C	c.(685-687)CAG>CAC	p.Q229H	PTCD1_uc011kiw.1_Missense_Mutation_p.Q278H	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	229	PPR 3.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGGGCGCTCTGTAGAGCTG	0.597000													4	63					0	0	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99654858	99654858	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:99654858G>A	uc003uso.2	+	2	373	c.229G>A	c.(229-231)GAG>AAG	p.E77K	ZSCAN21_uc011kje.1_Missense_Mutation_p.E76K|ZSCAN21_uc003usn.1_Missense_Mutation_p.E76K	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	77	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GCTGAGGCCCGAGATCCACAC	0.637000													5	40					0	0	0	0
FEZF1	389549	broad.mit.edu	37	7	121942917	121942917	+	Silent	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:121942917G>A	uc003vkd.2	-	3	1079	c.1005C>T	c.(1003-1005)ACC>ACT	p.T335T	FEZF1_uc003vkc.2_Silent_p.T285T|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	335	C2H2-type 3.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CGTGTATTCGGGTATGAGTGT	0.408000													26	62					0	0	0	0
ZNF786	136051	broad.mit.edu	37	7	148777738	148777738	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:148777738C>G	uc003wfh.2	-	2	227	c.90G>C	c.(88-90)CAG>CAC	p.Q30H	ZNF786_uc011kuk.1_5'UTR|ZNF786_uc003wfi.2_Intron	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			AAAGTTCCTTCTGCCATGCCT	0.428000													3	55					0	0	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11188846	11188846	+	Silent	SNP	C	T	T	rs148317481		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:11188846C>T	uc003wtp.1	+	1	352	c.231C>T	c.(229-231)TGC>TGT	p.C77C		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	77	DUF6 1.|Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TCTGTCGATGCCTCTTCCACC	0.627000													29	246					0	0	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38148029	38148029	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:38148029C>T	uc003xli.2	-	17	3600	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	WHSC1L1_uc011lbm.1_Missense_Mutation_p.E1028K|WHSC1L1_uc010lwe.2_Missense_Mutation_p.E979K	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1028					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GTCTGCCCTTCAGCAAAGCTT	0.443000			T	NUP98	AML								8	171					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618162	77618162	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:77618162C>T	uc003yav.2	+	2	2226	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	ZFHX4_uc003yat.1_Silent_p.I613I|ZFHX4_uc003yau.1_Silent_p.I613I|ZFHX4_uc003yaw.1_Silent_p.I613I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	613	C2H2-type 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGTGGCATCGAGTGTCCAA	0.557000										HNSCC(33;0.089)			6	80					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100832288	100832288	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:100832288G>C	uc003yiv.2	+	49	9118	c.9007G>C	c.(9007-9009)GAA>CAA	p.E3003Q	VPS13B_uc003yiw.2_Missense_Mutation_p.E2978Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3003					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGGCTATTTGAAGGAGAGAA	0.378000													4	105					0	0	0	0
RNF139	11236	broad.mit.edu	37	8	125498991	125498991	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:125498991C>T	uc003yrc.2	+	2	1444	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	367	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCATTTTATCCATGGAATGA	0.423000									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				19	202					0	0	0	0
BAI1	575	broad.mit.edu	37	8	143569790	143569790	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr8:143569790C>T	uc003ywm.2	+	13	2557	c.2374C>T	c.(2374-2376)CGG>TGG	p.R792W		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	792	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAAGGGCTGGCGGGCCACGGG	0.632000													5	119					0	0	0	0
TRPM3	80036	broad.mit.edu	37	9	73164531	73164531	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr9:73164531C>G	uc004aid.2	-	24	3842	c.3598G>C	c.(3598-3600)GAA>CAA	p.E1200Q	TRPM3_uc004ahu.2_Missense_Mutation_p.E1042Q|TRPM3_uc004ahv.2_Missense_Mutation_p.E1002Q|TRPM3_uc004ahw.2_Missense_Mutation_p.E1072Q|TRPM3_uc004ahx.2_Missense_Mutation_p.E1059Q|TRPM3_uc004ahy.2_Missense_Mutation_p.E1062Q|TRPM3_uc004ahz.2_Missense_Mutation_p.E1049Q|TRPM3_uc004aia.2_Missense_Mutation_p.E1047Q|TRPM3_uc004aib.2_Missense_Mutation_p.E1037Q|TRPM3_uc004aic.2_Missense_Mutation_p.E1200Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1225	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAGTATTCTTCTATGCATTGC	0.413000													3	71					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139399790	139399790	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr9:139399790C>G	uc004chz.2	-	25	4558	c.4558G>C	c.(4558-4560)GAC>CAC	p.D1520H	NOTCH1_uc004cia.1_Missense_Mutation_p.D750H	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1520	Extracellular (Potential).|LNR 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGCTGGCAGTCAAAGCCGTCG	0.627000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			2	6					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412284	139412284	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr9:139412284T>G	uc004chz.2	-	8	1361	c.1361A>C	c.(1360-1362)AAC>ACC	p.N454T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	454	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GACGCACTCGTTGACGTCGAT	0.657000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			11	84					0	0	0	0
RBBP7	5931	broad.mit.edu	37	X	16863980	16863980	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:16863980C>G	uc004cxt.2	-	11	1538	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q	RBBP7_uc004cxs.1_Missense_Mutation_p.E438Q|RBBP7_uc004cxu.2_Missense_Mutation_p.E385Q	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	394	WD 7.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					ATGTTATCCTCAGACACTGAG	0.353000													4	45					0	0	0	0
RAI2	10742	broad.mit.edu	37	X	17819471	17819471	+	Silent	SNP	G	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:17819471G>T	uc004cyf.2	-	3	1230	c.660C>A	c.(658-660)CCC>CCA	p.P220P	RAI2_uc004cyg.2_Silent_p.P220P|RAI2_uc010nfa.2_Silent_p.P220P|RAI2_uc004cyh.3_Silent_p.P220P|RAI2_uc011miy.1_Silent_p.P170P	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	220	Pro-rich.				embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GGGGGGACAAGGGGGAGCTAA	0.632000													24	35					6.44725e-10	7.25316e-10	1	0
FAM47B	170062	broad.mit.edu	37	X	34961653	34961653	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:34961653C>T	uc004ddi.1	+	1	723	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	235	Pro-rich.									ovary(3)|breast(1)	4						TGTCCAGTCTCCACCCGGAAC	0.637000													6	105					0	0	0	0
OGT	8473	broad.mit.edu	37	X	70787880	70787880	+	Silent	SNP	C	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:70787880C>T	uc004eaa.1	+	21	3097	c.2880C>T	c.(2878-2880)CTC>CTT	p.L960L	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.L950L|OGT_uc004eac.2_Silent_p.L821L|OGT_uc004ead.2_Silent_p.L579L	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	960					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					CATCCCAGCTCACTTGCTTAG	0.383000													16	110					0	0	0	0
GLA	2717	broad.mit.edu	37	X	100662806	100662806	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:100662806G>A	uc004ehl.1	-	1	196	c.86C>T	c.(85-87)GCT>GTT	p.A29V	HNRNPH2_uc004ehm.2_5'Flank|HNRNPH2_uc004ehn.2_5'Flank|GLA_uc011mrj.1_Missense_Mutation_p.A29V	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	29					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	CAGTGCTCTAGCCCCAGGGAT	0.602000													5	137					0	0	0	0
SOX3	6658	broad.mit.edu	37	X	139586097	139586097	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:139586097C>G	uc004fbd.1	-	1	1129	c.1129G>C	c.(1129-1131)GAG>CAG	p.E377Q		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	377					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GAGCTGGGCTCAGACTTCACT	0.473000													4	16					0	0	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870209	151870209	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chrX:151870209C>A	uc004ffq.1	+	3	1093	c.899C>A	c.(898-900)TCC>TAC	p.S300Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.S300Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	300	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCGCATTTCCTACCCACTC	0.562000													7	227					5.18039e-06	5.7257e-06	1	0
VPS13D	55187	broad.mit.edu	37	1	12569009	12569009	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:12569009delC	uc001atv.2	+	70	13239	c.13098delC	c.(13096-13098)AGCfs	p.S4366fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.S4341fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.S3553fs|VPS13D_uc009vnl.2_RNA|VPS13D_uc010obd.1_Frame_Shift_Del_p.S364fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4365					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACGCAAAGAGCCTCTACTATG	0.522													---	---	---							
Unknown	0	broad.mit.edu	37	1	94871897	94871897	+	IGR	DEL	T	-	-	rs140254585		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:94871897delT								ARHGAP29 (131273 upstream) : ABCD3 (12036 downstream)																							TTTTGTTTTGTTTTTTTTTTT	0.184													---	---	---							
Unknown	0	broad.mit.edu	37	12	113492284	113492285	+	IGR	INS	-	A	A	rs34462445		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:113492284_113492285insA								OAS2 (42757 upstream) : DTX1 (3377 downstream)																							CTCAATGGACCAAAAAAAAAAA	0.381													---	---	---							
MGA	23269	broad.mit.edu	37	15	42059359	42059359	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:42059359delA	uc010ucy.1	+	24	9260	c.9079delA	c.(9079-9081)AAAfs	p.K3027fs	MGA_uc010ucz.1_Frame_Shift_Del_p.K2818fs	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2988						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGTTGGACACAAAATGAACTT	0.493													---	---	---							
Unknown	0	broad.mit.edu	37	17	25289230	25289233	+	IGR	DEL	TCTA	-	-	rs138697975		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:25289230_25289233delTCTA								None (None upstream) : WSB1 (331873 downstream)																							GTTTGTTACCTCTATCTATTGACT	0.343													---	---	---							
ARVCF	421	broad.mit.edu	37	22	19958829	19958829	+	Frame_Shift_Del	DEL	G	-	-	rs5993890	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:19958829delG	uc002zqz.2	-	19	3082	c.2811delC	c.(2809-2811)CCCfs	p.P937fs	ARVCF_uc002zqy.2_Intron	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	937					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TGCTGGGCCCGGGGGGAGGGG	0.657											OREG0026306	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
Unknown	0	broad.mit.edu	37	4	174555577	174555579	+	IGR	DEL	TTT	-	-	rs34026730		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:174555577_174555579delTTT								MORF4 (17783 upstream) : FBXO8 (602233 downstream)																							CTCTTATTCCttttttttttttt	0.261													---	---	---							
FAT1	2195	broad.mit.edu	37	4	187539957	187539959	+	In_Frame_Del	DEL	GTG	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187539957_187539959delGTG	uc003izf.2	-	10	7969_7971	c.7781_7783delCAC	c.(7780-7785)CCACAA>CAA	p.P2594del		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2594	Extracellular (Potential).|Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCTCGAAATTGTGGTGCATTGTC	0.453										HNSCC(5;0.00058)			---	---	---							
FAT2	2196	broad.mit.edu	37	5	150924152	150924153	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:150924152_150924153insT	uc003lue.3	-	9	6548_6549	c.6535_6536insA	c.(6535-6537)AGAfs	p.R2179fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2179	Cadherin 19.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGGTACTCTGACTTTGTAA	0.500													---	---	---							
SYNE1	23345	broad.mit.edu	37	6	152841678	152841678	+	Splice_Site	DEL	C	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:152841678delC	uc010kiw.2	-	6	828	c.226_splice	c.e6-1	p.P76_splice	SYNE1_uc003qot.3_Splice_Site_p.P76_splice|SYNE1_uc003qou.3_Splice_Site_p.P76_splice|SYNE1_uc010kjb.1_Splice_Site_p.P76_splice|SYNE1_uc003qpa.1_Splice_Site_p.P76_splice	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCACAAGGCTGTAAAAAGT	0.368										HNSCC(10;0.0054)			---	---	---							
LRRC17	10234	broad.mit.edu	37	7	102584992	102584993	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:102584992_102584993insA	uc003vau.2	+	4	1653_1654	c.1264_1265insA	c.(1264-1266)GAAfs	p.E422fs	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_3'UTR	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	422					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						TGATGAATGGGAAAAAAAACAT	0.337													---	---	---							
TAS2R41	259287	broad.mit.edu	37	7	143175518	143175518	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:143175518delA	uc003wdc.1	+	1	553	c.553delA	c.(553-555)AAAfs	p.K185fs	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	185	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCCATCCCTGAAACTGGTCAT	0.368													---	---	---							
NOTCH1	4851	broad.mit.edu	37	9	139418203	139418204	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139418203_139418204insT	uc004chz.2	-	3	368_369	c.368_369insA	c.(367-369)ACGfs	p.T123fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	123	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACTTGTACTCCGTCAGCGTGAG	0.708			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---							
VPS13D	55187	broad.mit.edu	37	1	12569009	12569009	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:12569009delC	uc001atv.2	+	70	13239	c.13098delC	c.(13096-13098)AGCfs	p.S4366fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.S4341fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.S3553fs|VPS13D_uc009vnl.2_RNA|VPS13D_uc010obd.1_Frame_Shift_Del_p.S364fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4365					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACGCAAAGAGCCTCTACTATG	0.522													---	---	---							
C1orf135	79000	broad.mit.edu	37	1	26186960	26186960	+	5'Flank	DEL	T	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr1:26186960delT	uc001bkw.1	-							NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein												0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AATTTTGTAATTTTTTTTTTT	0.274													---	---	---							
OR8D4	338662	broad.mit.edu	37	11	123777441	123777442	+	Frame_Shift_Ins	INS	-	T	T	rs79561639	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr11:123777441_123777442insT	uc010saa.1	+	1	303_304	c.303_304insT	c.(301-306)CTGTTTfs	p.L101fs		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	101_102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGATTCAGCTGTTTTTTTTCTG	0.436													---	---	---							
NF1P1	440225	broad.mit.edu	37	15	21135196	21135197	+	5'Flank	DEL	GT	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr15:21135196_21135197delGT	uc001ytv.1	-											Human NF1-related locus DNA in A9 mouse DNA background.												0						gtcttTGAGAgtgtgtgtgtgt	0.233													---	---	---							
Unknown	0	broad.mit.edu	37	17	25289230	25289233	+	IGR	DEL	TCTA	-	-	rs138697975		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr17:25289230_25289233delTCTA								None (None upstream) : WSB1 (331873 downstream)																							GTTTGTTACCTCTATCTATTGACT	0.343													---	---	---							
MYO9B	4650	broad.mit.edu	37	19	17294679	17294680	+	Splice_Site	INS	-	A	A			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr19:17294679_17294680insA	uc010eak.2	+	16	2525	c.2373_splice	c.e16+2	p.K791_splice	MYO9B_uc002nfi.2_Splice_Site_p.K791_splice|MYO9B_uc002nfj.1_Splice_Site_p.K791_splice	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						ATTCCAAAGGTAAAAAAAAAAA	0.411													---	---	---							
SEC23B	10483	broad.mit.edu	37	20	18485750	18485751	+	5'Flank	INS	-	AA	AA	rs74180905		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr20:18485750_18485751insAA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GCCTCATTCAGAAAAAAAAAAA	0.371													---	---	---							
ARVCF	421	broad.mit.edu	37	22	19958829	19958829	+	Frame_Shift_Del	DEL	G	-	-	rs5993890	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr22:19958829delG	uc002zqz.2	-	19	3082	c.2811delC	c.(2809-2811)CCCfs	p.P937fs	ARVCF_uc002zqy.2_Intron	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	937					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TGCTGGGCCCGGGGGGAGGGG	0.657											OREG0026306	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
FAT2	2196	broad.mit.edu	37	5	150924152	150924153	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr5:150924152_150924153insT	uc003lue.3	-	9	6548_6549	c.6535_6536insA	c.(6535-6537)AGAfs	p.R2179fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2179	Cadherin 19.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGGTACTCTGACTTTGTAA	0.500													---	---	---							
SYNE1	23345	broad.mit.edu	37	6	152841678	152841678	+	Splice_Site	DEL	C	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr6:152841678delC	uc010kiw.2	-	6	828	c.226_splice	c.e6-1	p.P76_splice	SYNE1_uc003qot.3_Splice_Site_p.P76_splice|SYNE1_uc003qou.3_Splice_Site_p.P76_splice|SYNE1_uc010kjb.1_Splice_Site_p.P76_splice|SYNE1_uc003qpa.1_Splice_Site_p.P76_splice	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCACAAGGCTGTAAAAAGT	0.368										HNSCC(10;0.0054)			---	---	---							
TAS2R41	259287	broad.mit.edu	37	7	143175518	143175518	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:143175518delA	uc003wdc.1	+	1	553	c.553delA	c.(553-555)AAAfs	p.K185fs	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	185	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCCATCCCTGAAACTGGTCAT	0.368													---	---	---							
Unknown	0	broad.mit.edu	37	7	148888416	148888419	+	IGR	DEL	CTCA	-	-	rs147356472		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr7:148888416_148888419delCTCA								ZNF398 (8300 upstream) : ZNF282 (4158 downstream)																							gagatggagtctcactctgtcgcc	0.172													---	---	---							
NOTCH1	4851	broad.mit.edu	37	9	139418203	139418204	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr9:139418203_139418204insT	uc004chz.2	-	3	368_369	c.368_369insA	c.(367-369)ACGfs	p.T123fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	123	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACTTGTACTCCGTCAGCGTGAG	0.708			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---							
