Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GOLGA5	9950	broad.mit.edu	37	14	93264023	93264023	+	Missense_Mutation	SNP	A	A	C			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr14:93264023A>C	uc001yaz.1	+	1	423	c.241A>C	c.(241-243)Act>Cct	p.T81P		NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Homo sapiens golgin A5 (GOLGA5), mRNA.	81					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|Rab GTPase binding|protein homodimerization activity|protein tyrosine kinase activity	p.T81P(1)		large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CTTAGCTGGCACTGCAAATGT	0.413000			T	RET	papillary thyroid								10	175					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10430104	10430104	+	Silent	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr17:10430104G>A	uc010coi.3	-	29	4127	c.3999C>T	c.(3997-3999)aaC>aaT	p.N1333N	AK097500_uc002gml.1_Intron|MYH2_uc002gmp.4_Silent_p.N1333N|MYH2_uc010coj.3_Intron	NM_001100112	NP_060004	Q9UKX2	MYH2_HUMAN	Homo sapiens myosin, heavy chain 2, skeletal muscle, adult (MYH2), transcript variant 2, mRNA.	1333					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	ATP binding|actin binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.N1333N(2)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCGCCAGGGCGTTCTTGGCCT	0.498000													5	151					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186094769	186094769	+	Missense_Mutation	SNP	A	A	G			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr1:186094769A>G	uc001grq.1	+	81	12762	c.12533A>G	c.(12532-12534)tAc>tGc	p.Y4178C	MIR548F1_uc021pgf.1_Intron|HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	Homo sapiens hemicentin 1 (HMCN1), mRNA.	4178	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.Y4178C(2)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GAAGGACACTACACGGTCAAT	0.388000													5	98					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27782957	27782957	+	Silent	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr16:27782957G>A	uc002dow.3	+	21	4206	c.4182G>A	c.(4180-4182)ccG>ccA	p.P1394P		NM_015202	NP_056017	O60303	K0556_HUMAN	Homo sapiens KIAA0556 (KIAA0556), mRNA.	1394								p.P1394P(6)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						ACGAGGCACCGCTGATGCCCT	0.607000													7	134					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540002	133540002	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr2:133540002G>A	uc002ttp.3	-	13	4756	c.4382C>T	c.(4381-4383)gCt>gTt	p.A1461V	NCKAP5_uc002ttq.3_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Homo sapiens NCK-associated protein 5 (NCKAP5), transcript variant 1, mRNA.	1461							protein binding	p.A1461V(2)|p.A1461S(1)		NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TGAACTCACAGCATCAGTCGC	0.502000													19	68					0	0	1	0	0
BANF2	140836	broad.mit.edu	37	20	17705710	17705710	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr20:17705710G>A	uc010zrs.1	+	1	75	c.61G>A	c.(61-63)Gaa>Aaa	p.E21K	BANF2_uc002wqa.2_Missense_Mutation_p.E14K|BANF2_uc002wpz.2_Missense_Mutation_p.E14K	NM_001159495	NP_848572	Q9H503	BAFL_HUMAN	Homo sapiens barrier to autointegration factor 2 (BANF2), transcript variant 3, mRNA.	14						cytoplasm|nucleus	DNA binding	p.E14K(1)		large_intestine(1)|lung(1)|prostate(3)|skin(1)	6						CTTCCTCTCCGAACCCATTGG	0.502000													42	161					0	0	1	0	0
TXNDC11	51061	broad.mit.edu	37	16	11785489	11785489	+	Silent	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr16:11785489G>A	uc010buu.1	-	8	1700	c.1638C>T	c.(1636-1638)ttC>ttT	p.F546F	TXNDC11_uc002dbg.1_Silent_p.F519F	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	Homo sapiens thioredoxin domain containing 11 (TXNDC11), mRNA.	546					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane		p.P546L(1)|p.F519F(1)		endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						CAGAGTCGATGAAGCCTGACA	0.468000													98	205					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184104857	184104857	+	Missense_Mutation	SNP	A	A	G			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr3:184104857A>G	uc003fov.3	+	17	2555	c.2309A>G	c.(2308-2310)gAc>gGc	p.D770G	CHRD_uc003fow.3_Missense_Mutation_p.D400G|CHRD_uc003fox.3_Missense_Mutation_p.D770G|CHRD_uc003foy.3_Missense_Mutation_p.D400G|CHRD_uc010hyc.3_Missense_Mutation_p.D360G|CHRD_uc011brr.2_Missense_Mutation_p.D312G	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	Homo sapiens chordin (CHRD), mRNA.	770					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding	p.D770G(2)|p.D483G(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATGTCAGAGACTTGCCAGGG	0.592000													20	78					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29628247	29628247	+	Missense_Mutation	SNP	C	C	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr22:29628247C>A	uc003aem.3	+	7	754	c.679C>A	c.(679-681)Cca>Aca	p.P227T	EMID1_uc003aen.3_Missense_Mutation_p.P225T|EMID1_uc021wnr.1_5'Flank	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	Homo sapiens EMI domain containing 1 (EMID1), mRNA.	225	Collagen-like.					collagen		p.P227T(2)		NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						CATTGCAGGTCCACAGGGCCC	0.687000													46	94					0	0	1	0	0
PANK1	53354	broad.mit.edu	37	10	91359112	91359112	+	Missense_Mutation	SNP	A	A	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr10:91359112A>T	uc001kgp.2	-	2	1477	c.1207T>A	c.(1207-1209)Tgc>Agc	p.C403S	PANK1_uc001kgn.2_Missense_Mutation_p.C178S|PANK1_uc001kgo.2_Missense_Mutation_p.C178S|PANK1_uc009xtu.2_Missense_Mutation_p.C205S	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	Homo sapiens pantothenate kinase 1 (PANK1), transcript variant alpha, mRNA.	403					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity	p.C403S(2)		cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	TTATCAAGGCAGTACGGCTTT	0.448000													38	338					0	0	1	0	0
PGAP3	93210	broad.mit.edu	37	17	37830251	37830251	+	Silent	SNP	G	G	A	rs147768703	byFrequency	TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr17:37830251G>A	uc002hsj.3	-	4	595	c.552C>T	c.(550-552)tgC>tgT	p.C184C	PGAP3_uc010cvy.3_Non-coding_Transcript|PGAP3_uc010wej.2_Silent_p.C163C|PGAP3_uc002hsk.3_Silent_p.C133C|PGAP3_uc010cvz.3_Intron	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	Homo sapiens post-GPI attachment to proteins 3 (PGAP3), mRNA.	184					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds	p.C184C(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12						CTCACCTGACGCAGCACAGGT	0.587000													20	36					0	0	1	0	0
BC139719	0	broad.mit.edu	37	16	90161168	90161168	+	Missense_Mutation	SNP	T	T	G	rs8055740		TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr16:90161168T>G	uc002fqq.3	+	2	398	c.398T>G	c.(397-399)cTc>cGc	p.L133R	BC139719_uc002fqp.3_Intron					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.																		CCTCCTGTCCTCCGAGTCGAG	0.622000													3	7					0	0	1	0	0
BC128131	0	broad.mit.edu	37	19	23159308	23159308	+	Missense_Mutation	SNP	A	A	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr19:23159308A>T	uc002nqz.1	-	1	665	c.639T>A	c.(637-639)agT>agA	p.S213R	BC128131_uc002nqy.1_Non-coding_Transcript					Homo sapiens zinc finger protein 117, mRNA (cDNA clone IMAGE:40112371).																		CTCCAGCATGACTTCTCTTAT	0.418000													4	131					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40934857	40934857	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr17:40934857G>A	uc002ibj.3	+	1	768	c.700G>A	c.(700-702)Gtc>Atc	p.V234I	WNK4_uc010wgx.2_5'UTR|WNK4_uc002ibk.1_5'Flank|WNK4_uc010wgy.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), mRNA.	234	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity	p.V234I(2)|p.V222I(1)		NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCCAACATCGTCCGCTTCTA	0.602000													24	60					0	0	1	0	0
TRIM41	90933	broad.mit.edu	37	5	180651243	180651243	+	Missense_Mutation	SNP	T	T	G			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr5:180651243T>G	uc003mne.2	+	0	981	c.244T>G	c.(244-246)Tgg>Ggg	p.W82G	TRNA_Lys_uc021ykf.1_5'Flank|TRNA_Val_uc021ykg.1_5'Flank|MIR4638_uc021ykh.1_5'Flank|AX748230_uc003mnb.1_3'UTR|TRIM41_uc003mnc.2_Missense_Mutation_p.W82G|TRIM41_uc003mnd.2_Missense_Mutation_p.W82G|TRIM41_uc003mnf.2_Non-coding_Transcript	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	Homo sapiens tripartite motif containing 41 (TRIM41), transcript variant 1, mRNA.	82	Glu-rich.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding	p.W82G(6)		NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCGCGGGGTGGGACACCCC	0.627000													8	82					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764546	138764546	+	Missense_Mutation	SNP	G	G	C			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr7:138764546G>C	uc003vun.3	-	3	1529	c.1141C>G	c.(1141-1143)Cta>Gta	p.L381V	ZC3HAV1_uc003vuo.3_5'Flank|ZC3HAV1_uc003vup.3_Missense_Mutation_p.L381V	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	Homo sapiens zinc finger CCCH-type, antiviral 1 (ZC3HAV1), transcript variant 1, mRNA.	381					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding	p.L381V(2)		cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						GCGGCAGGTAGCGTGGGAGAA	0.532000													68	201					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119550	19119550	+	Missense_Mutation	SNP	C	C	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr22:19119550C>A	uc002zow.2	+	0	1230	c.638C>A	c.(637-639)tCc>tAc	p.S213Y	DGCR14_uc002zou.3_3'UTR	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	Homo sapiens testis-specific serine kinase 2 (TSSK2), mRNA.	213	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.S213Y(3)		endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					GTCTGCGGCTCCATGCCCTAT	0.592000													87	144					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156835562	156835562	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr4:156835562C>T	uc003ipf.1	+	7	878	c.814C>T	c.(814-816)Cgt>Tgt	p.R272C		NM_005651	NP_005642	P48775	T23O_HUMAN	Homo sapiens tryptophan 2,3-dioxygenase (TDO2), mRNA.	272					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity	p.R272C(2)		breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	TGATGAGAAACGTCATGAACA	0.348000													17	46					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15731856	15731856	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr12:15731856C>T	uc001rcv.2	+	19	3369	c.2899C>T	c.(2899-2901)Cgt>Tgt	p.R967C	PTPRO_uc001rcw.2_Missense_Mutation_p.R939C|PTPRO_uc001rcx.2_Missense_Mutation_p.R156C|PTPRO_uc001rcy.2_Missense_Mutation_p.R156C|PTPRO_uc001rcz.2_Missense_Mutation_p.R128C|PTPRO_uc001rda.2_Missense_Mutation_p.R128C	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, O (PTPRO), transcript variant 1, mRNA.	967	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R967C(2)		NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				ATGTAAAAACCGTTACACAAA	0.393000													21	129					0	0	1	0	0
ZNF782	158431	broad.mit.edu	37	9	99580381	99580381	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr9:99580381C>T	uc004awp.1	-	5	2205	c.1924G>A	c.(1924-1926)Ggg>Agg	p.G642R	ZNF782_uc011lup.1_Missense_Mutation_p.G510R	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	Homo sapiens zinc finger protein 782 (ZNF782), mRNA.	642					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G642R(2)|p.G642E(1)		NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				GGTTTCTCCCCGGTGTGAGTT	0.433000													7	233					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129155089	129155089	+	Missense_Mutation	SNP	C	C	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chrX:129155089C>A	uc022cdu.1	+	3	3615	c.3571C>A	c.(3571-3573)Cag>Aag	p.Q1191K	BCORL1_uc010nrd.1_Missense_Mutation_p.Q1093K	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	Homo sapiens BCL6 corepressor-like 1 (BCORL1), mRNA.	1191					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus		p.Q1191K(2)		breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GCCGGAGTCCCAGTCTCCAGG	0.622000													3	23					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88583140	88583140	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr11:88583140G>A	uc001pcq.3	-	1	1045	c.845C>T	c.(844-846)aCg>aTg	p.T282M	GRM5_uc009yvm.3_Missense_Mutation_p.T282M	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	Homo sapiens glutamate receptor, metabotropic 5 (GRM5), transcript variant a, mRNA.	282					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.T282M(3)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACCTCTCACCGTCATGCCCTC	0.522000													53	112					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158617396	158617396	+	Missense_Mutation	SNP	G	G	A	rs143642542	by1000genomes	TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr1:158617396G>A	uc001fst.1	-	26	4028	c.3829C>T	c.(3829-3831)Cgt>Tgt	p.R1277C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	Homo sapiens spectrin, alpha, erythrocytic 1 (elliptocytosis 2) (SPTA1), mRNA.	1277					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R1277C(2)|p.R1277L(2)|p.R1277H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCCTTTGTACGCCCCTGCAGG	0.562000													14	208					0	0	1	0	0
BC139719	0	broad.mit.edu	37	16	90161578	90161578	+	Silent	SNP	G	G	A	rs13337896	by1000genomes	TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr16:90161578G>A	uc002fqq.3	+	3	504	c.504G>A	c.(502-504)acG>acA	p.T168T	BC139719_uc002fqp.3_Silent_p.T151T					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.									p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													5	54					0	0	1	0	0
CCNA1	8900	broad.mit.edu	37	13	37006834	37006834	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr13:37006834G>A	uc001uvr.4	+	0	426	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	CCNA1_uc010teo.2_Intron|CCNA1_uc010abq.3_Intron|CCNA1_uc010abp.3_Intron|CCNA1_uc001uvs.4_Missense_Mutation_p.E26K|CCNA1_uc010abr.3_Non-coding_Transcript	NM_003914	NP_001104517	P78396	CCNA1_HUMAN	Homo sapiens cyclin A1 (CCNA1), transcript variant 1, mRNA.	26					G2/M transition of mitotic cell cycle|cell division|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding	p.E26K(2)		breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TCTCAGCTGGGAAGGACCGGG	0.552000													11	41					0	0	1	0	0
UGP2	7360	broad.mit.edu	37	2	64114692	64114692	+	Missense_Mutation	SNP	A	A	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr2:64114692A>T	uc010ypx.2	+	7	1262	c.1255A>T	c.(1255-1257)Agt>Tgt	p.S419C	UGP2_uc002scl.3_Missense_Mutation_p.S399C|UGP2_uc002scm.3_Missense_Mutation_p.S410C	NM_001001521	NP_001001521	Q16851	UGPA_HUMAN	Homo sapiens UDP-glucose pyrophosphorylase 2 (UGP2), transcript variant 2, mRNA.	410					UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|glycogen biosynthetic process|phosphorylation|xenobiotic metabolic process	cytosol	UTP:glucose-1-phosphate uridylyltransferase activity|metal ion binding|protein binding	p.S410C(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						AAACCTCTATAGTCTTAATGC	0.403000													8	246					0	0	1	0	0
FYTTD1	84248	broad.mit.edu	37	3	197497068	197497068	+	Silent	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr3:197497068G>A	uc003fyi.2	+	3	669	c.450G>A	c.(448-450)caG>caA	p.Q150Q	FYTTD1_uc011bui.1_Silent_p.Q124Q|FYTTD1_uc011buj.1_Intron|FYTTD1_uc011buk.1_Silent_p.Q83Q	NM_032288	NP_115664	Q96QD9	UIF_HUMAN	Homo sapiens forty-two-three domain containing 1 (FYTTD1), transcript variant 1, mRNA.	150					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding	p.Q150Q(2)		kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		ATGAAGGGCAGAGGAAACCAG	0.348000													4	21					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385748	58385748	+	Missense_Mutation	SNP	G	G	A	rs145250945		TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr19:58385748G>A	uc002qqo.2	-	2	1282	c.1010C>T	c.(1009-1011)gCt>gTt	p.A337V	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	337					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.A337V(4)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ACTGAAGCTAGCATATTTGCT	0.353000													5	11					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66463350	66463350	+	Missense_Mutation	SNP	T	T	G			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr3:66463350T>G	uc003dmx.3	-	5	750	c.736A>C	c.(736-738)Aac>Cac	p.N246H	LRIG1_uc010hnz.3_5'UTR|LRIG1_uc010hoa.3_Missense_Mutation_p.N246H	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), mRNA.	246						integral to membrane		p.N246H(3)		NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TTGCTGATGTTGTTTCGCTGA	0.532000													16	60					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606429	55606429	+	Missense_Mutation	SNP	C	C	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr11:55606429C>A	uc010rio.2	+	0	202	c.202C>A	c.(202-204)Ctc>Atc	p.L68I		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily D, member 16 (OR5D16), mRNA.	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L68I(2)		cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				CCTCAACCACCTCTCCTTTGT	0.433000													77	475					0	0	1	0	0
C10orf81	79949	broad.mit.edu	37	10	115527188	115527188	+	Silent	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr10:115527188C>T	uc001lat.2	+	3	853	c.291C>T	c.(289-291)gtC>gtT	p.V97V	C10orf81_uc009xyc.2_Silent_p.V15V|C10orf81_uc001lar.2_Silent_p.V103V|C10orf81_uc001las.2_Silent_p.V15V	NM_182601	NP_872407	Q5SXH7	CJ081_HUMAN	Homo sapiens chromosome 10 open reading frame 81 (C10orf81), transcript variant 1, mRNA.	97	PH.							p.V103V(1)|p.V15V(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)	15		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		CTGATGAGGTCATGTCCATCA	0.403000													25	73					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22120821	22120821	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr16:22120821G>A	uc010vbq.2	+	6	598	c.502G>A	c.(502-504)Ggg>Agg	p.G168R	VWA3A_uc010bxc.2_Missense_Mutation_p.G155R	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	Homo sapiens von Willebrand factor A domain containing 3A (VWA3A), mRNA.	168						extracellular region		p.G168R(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCTCATCAAAGGGGCCAGAGT	0.512000													9	16					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964266	7964266	+	Silent	SNP	A	A	C			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr19:7964266A>C	uc002mir.3	+	2	960	c.859A>C	c.(859-861)Agg>Cgg	p.R287R		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member E (LRRC8E), mRNA.	287						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						GGTGGCCTGTAGGGTGGAGAC	0.542000													3	93					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209212747	209212747	+	Splice_Site	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr2:209212747G>A	uc002vcz.3	+	35	5532	c.5374_splice	c.e35+1	p.D1792_splice		NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	Homo sapiens phosphoinositide kinase, FYVE finger containing (PIKFYVE), transcript variant 2, mRNA.	1792	PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding	p.D1792N(2)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TGAGCCTCAAGGTGTGTTAAA	0.408000													5	172					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995013	144995013	+	Silent	SNP	G	G	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr8:144995013G>T	uc003zaf.1	-	31	9557	c.9387C>A	c.(9385-9387)atC>atA	p.I3129I	PLEC_uc003zab.1_Silent_p.I2992I|PLEC_uc003zac.1_Silent_p.I2996I|PLEC_uc003zad.2_Silent_p.I2992I|PLEC_uc003zae.1_Silent_p.I2960I|PLEC_uc003zag.1_Silent_p.I2970I|PLEC_uc003zah.2_Silent_p.I2978I|PLEC_uc003zaj.2_Silent_p.I3019I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	Homo sapiens plectin (PLEC), transcript variant 6, mRNA.	3129	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle	p.I3129I(2)|p.I3019I(1)		NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCTCGCGGTCGATGACCCTGC	0.672000													3	32					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43138780	43138780	+	Missense_Mutation	SNP	A	A	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr17:43138780A>T	uc002ihz.3	+	0	101	c.83A>T	c.(82-84)gAg>gTg	p.E28V	DCAKD_uc010dab.1_5'Flank|NMT1_uc010dac.1_Non-coding_Transcript	NM_021079	NP_066565	P30419	NMT1_HUMAN	Homo sapiens N-myristoyltransferase 1 (NMT1), mRNA.	28					N-terminal protein myristoylation|activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity	p.E28V(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				AACGGCCATGAGCACTGCAGC	0.602000													3	36					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65559013	65559013	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr15:65559013C>T	uc002aoq.3	-	2	660	c.406G>A	c.(406-408)Gcc>Acc	p.A136T	PARP16_uc002aoo.3_Missense_Mutation_p.A136T|PARP16_uc002aop.3_Intron	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	Homo sapiens poly (ADP-ribose) polymerase family, member 16 (PARP16), mRNA.	136	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity	p.A136T(2)|p.N135N(1)		kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						TAAAATTTGGCGTTGGCTGGG	0.458000													4	86					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41384239	41384239	+	Missense_Mutation	SNP	T	T	G			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr15:41384239T>G	uc001zni.3	-	4	736	c.523A>C	c.(523-525)Agt>Cgt	p.S175R	INO80_uc010ucu.2_Non-coding_Transcript	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	Homo sapiens INO80 homolog (S. cerevisiae) (INO80), mRNA.	175	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				UV-damage excision repair|cell division|cellular response to UV|cellular response to ionizing radiation|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of DNA replication involved in S phase|positive regulation of cell growth|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly	Ino80 complex|microtubule	ATP binding|ATPase activity|DNA binding|DNA helicase activity|actin binding|alpha-tubulin binding	p.S175R(3)		NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TTGTCTTTACTATACTTATTT	0.373000													57	184					0	0	1	0	0
FAM50B	26240	broad.mit.edu	37	6	3850735	3850735	+	Silent	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr6:3850735C>T	uc003mvu.3	+	1	802	c.690C>T	c.(688-690)gcC>gcT	p.A230A	FAM50B_uc021ykt.1_Silent_p.A230A	NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	Homo sapiens family with sequence similarity 50, member B (FAM50B), mRNA.	230						nucleus		p.A230A(2)|p.S229F(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				TGCGCTCCGCCGGCGTGGAGC	0.652000													3	66					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15067354	15067354	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr19:15067354C>T	uc002naa.1	-	5	1110	c.1103G>A	c.(1102-1104)cGg>cAg	p.R368Q	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Missense_Mutation_p.R304Q	NM_005071	NP_005062	P48664	EAA4_HUMAN	Homo sapiens solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (SLC1A6), mRNA.	368					synaptic transmission	integral to plasma membrane|membrane fraction	L-aspartate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity	p.R368Q(2)		breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	GAAGGGGTTCCGGTGAGTGAC	0.607000													3	59					0	0	1	0	0
LOXL3	84695	broad.mit.edu	37	2	74763166	74763166	+	Missense_Mutation	SNP	G	G	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr2:74763166G>A	uc002smp.1	-	6	1277	c.1205C>T	c.(1204-1206)gCc>gTc	p.A402V	LOXL3_uc002smo.1_Missense_Mutation_p.A41V|LOXL3_uc010ffm.1_Missense_Mutation_p.A402V|LOXL3_uc002smq.1_Missense_Mutation_p.A257V|LOXL3_uc010ffn.1_Missense_Mutation_p.A257V	NM_032603	NP_115992	P58215	LOXL3_HUMAN	Homo sapiens lysyl oxidase-like 3 (LOXL3), mRNA.	402	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity	p.A402V(2)		endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						CCGGACCCCGGCATCCTGGCT	0.552000													5	162					0	0	1	0	0
HBG1	3047	broad.mit.edu	37	11	5275542	5275542	+	Missense_Mutation	SNP	C	C	T			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr11:5275542C>T	uc001mai.1	-	1	732	c.295G>A	c.(295-297)Gtg>Atg	p.V99M	HBG1_uc001mak.1_Non-coding_Transcript|HBG1_uc001maj.1_Missense_Mutation_p.V99M	NM_000559	NP_000550	P69891	HBG1_HUMAN	Homo sapiens hemoglobin, gamma A (HBG1), mRNA.	99					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding	p.V99M(1)		large_intestine(1)|lung(3)|skin(1)	5		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGGATCCACATGCAGCTTG	0.498000													46	276					0	0	1	0	0
NKX3-1	4824	broad.mit.edu	37	8	23539135	23539135	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr8:23539135delA	uc011kzx.2	-	1	352	c.304delT	c.(304-306)tatfs	p.Y102fs	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	Homo sapiens NK3 homeobox 1 (NKX3-1), transcript variant 1, mRNA.	102					negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding			large_intestine(3)|lung(4)|prostate(5)|skin(2)	14		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		TCCAACAGATAAGACCCCAAG	0.527													55	178	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28209153	28209154	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr8:28209153_28209154insA	uc003xgq.3	-	6	1179_1180	c.1091_1092insT	c.(1090-1092)ctgfs	p.L364fs	ZNF395_uc003xgt.3_Frame_Shift_Ins_p.L364fs|ZNF395_uc003xgr.3_Frame_Shift_Ins_p.L364fs|ZNF395_uc003xgs.3_Frame_Shift_Ins_p.L364fs	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	Homo sapiens zinc finger protein 395 (ZNF395), mRNA.	364					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GAAGAGCAGACAGAGGCAGGCC	0.663													13	257	---	---	---	---					
TCTN2	79867	broad.mit.edu	37	12	124171487	124171488	+	Frame_Shift_Ins	INS	-	ACGAC	ACGAC			TCGA-CH-5745-01A-11D-1576-08	TCGA-CH-5745-10A-01D-1576-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51db8439-c35f-472e-baf0-8e6e22833c39	e32b30c3-6ed3-42ce-ad17-69b26146f7e4	g.chr12:124171487_124171488insACGAC	uc001ufp.3	+	5	797_798	c.669_670insACGAC	c.(667-672)acgacgfs	p.T223fs	TCTN2_uc009zya.3_Frame_Shift_Ins_p.T222fs	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	Homo sapiens tectonic family member 2 (TCTN2), transcript variant 1, mRNA.	223					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CTGCTGGGACGACGACACGTGG	0.525													7	799	---	---	---	---					
