Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC12A3	6559	broad.mit.edu	37	16	56938317	56938317	+	Missense_Mutation	SNP	A	A	G			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr16:56938317A>G	uc002ekd.4	+	24	2923	c.2894A>G	c.(2893-2895)cAg>cGg	p.Q965R	SLC12A3_uc010ccm.3_Missense_Mutation_p.Q956R|SLC12A3_uc010ccn.3_Missense_Mutation_p.Q964R	NM_000339	NP_000330	P55017	S12A3_HUMAN	Homo sapiens solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3), transcript variant 1, mRNA.	956					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCCCTTCGGCAGGTGAGGCTG	0.537000													4	136					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124062285	124062285	+	Splice_Site	SNP	T	T	G			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr9:124062285T>G	uc004blf.1	+	1	205	c.144_splice	c.e1+2	p.R48_splice	GSN_uc004bld.1_Intron|GSN_uc010mvr.1_Intron|GSN_uc010mvq.1_Intron|GSN_uc010mvu.1_Intron|GSN_uc010mvt.1_Intron|GSN_uc010mvs.1_Intron|GSN_uc004ble.1_Intron|GSN_uc010mvv.1_Intron|GSN_uc011lyh.1_Intron|GSN_uc011lyi.1_Intron|GSN_uc011lyj.1_5'Flank	NM_000177	NP_000168	P06396	GELS_HUMAN	Homo sapiens gelsolin (GSN), transcript variant 1, mRNA.	48					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						gaggcgcgggtgagtgcccgg	0.697000													10	17					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29628273	29628273	+	Silent	SNP	C	C	T			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr22:29628273C>T	uc003aem.3	+	7	780	c.705C>T	c.(703-705)ggC>ggT	p.G235G	EMID1_uc003aen.3_Silent_p.G233G|EMID1_uc021wnr.1_5'Flank	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	Homo sapiens EMI domain containing 1 (EMID1), mRNA.	233	Collagen-like.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						GGAGCCCTGGCCGGGCTGGAG	0.697000													4	69					0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114417	27114417	+	Missense_Mutation	SNP	C	C	T			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr6:27114417C>T	uc003nix.2	-	0	221	c.161G>A	c.(160-162)gGc>gAc	p.G54D	Histone3_uc021yox.1_5'Flank|HIST1H2BK_uc021yoy.1_Missense_Mutation_p.G54D|HIST1H2AH_uc003niz.3_5'Flank|MIR3143_uc021yoz.1_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	Homo sapiens histone cluster 1, H2bk (HIST1H2BK), mRNA.	54					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding	p.T53T(1)		breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						AGAGGAGATGCCGGTGTCGGG	0.582000													5	293					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38060702	38060702	+	Silent	SNP	G	G	A			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr14:38060702G>A	uc001wuf.3	-	1	1599	c.1287C>T	c.(1285-1287)taC>taT	p.Y429Y	FOXA1_uc010tpz.2_Silent_p.Y396Y	NM_004496	NP_004487	P55317	FOXA1_HUMAN	Homo sapiens forkhead box A1 (FOXA1), mRNA.	429					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ACGTAGAGCCGTAAGGCGAGT	0.607000													4	64					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29624070	29624070	+	Missense_Mutation	SNP	G	G	A	rs79198850		TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr20:29624070G>A	uc010ztl.1	+	0	36	c.4G>A	c.(4-6)Gct>Act	p.A2T	FRG1B_uc002wvm.1_Intron|FRG1B_uc010ztj.1_Intron|FRG1B_uc010gdr.1_Intron|FRG1B_uc010ztk.1_Intron					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.									p.A32T(2)|p.R2M(1)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GCAGTTTATGGCTGTCAAATT	0.279000													3	18					0	0	1	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72339511	72339511	+	RNA	SNP	A	A	C			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr7:72339511A>C	uc010lal.1	-	0		c.145T>G								Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.																		CCACCACTCCATCTTCCTTTT	0.582000													4	33					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681963	100681963	+	Silent	SNP	T	T	C			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr7:100681963T>C	uc003uxp.1	+	2	7319	c.7266T>C	c.(7264-7266)gtT>gtC	p.V2422V	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	Homo sapiens mucin 17, cell surface associated (MUC17), mRNA.	2422	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACTCCTGTTGACACCAGCA	0.512000													5	588					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274150	39274150	+	Missense_Mutation	SNP	T	T	A			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr17:39274150T>A	uc002hvz.3	-	0	457	c.418A>T	c.(418-420)Agc>Tgc	p.S140C		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	140	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.S140C(4)|p.C139F(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ctggagatgctgcagctgggg	0.672000													5	53					0	0	1	0	0
ZNF717	100131827	broad.mit.edu	37	3	75790798	75790798	+	Silent	SNP	G	G	A			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr3:75790798G>A	uc011bgi.2	-	2	470	c.147C>T	c.(145-147)gaC>gaT	p.D49D	ZNF717_uc003dpw.3_Non-coding_Transcript	NM_001128223	NP_001121695	C9JSV9	C9JSV9_HUMAN	Homo sapiens zinc finger protein 717 (ZNF717), mRNA.	49					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			autonomic_ganglia(6)|endometrium(3)|lung(2)|ovary(1)|stomach(7)	19						CCAGCATCACGTCCCTGTACA	0.502000													5	7					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145327548	145327548	+	Missense_Mutation	SNP	A	A	G			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr1:145327548A>G	uc021oul.1	+	31	4140	c.4105A>G	c.(4105-4107)Aat>Gat	p.N1369D	NBPF10_uc021ots.1_Intron|NBPF10_uc010oye.2_Intron|NBPF10_uc010oyi.2_Intron|NBPF10_uc010oyj.2_Intron|NBPF10_uc010oyl.2_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc021oum.1_Intron|NBPF10_uc021oun.1_Intron|NBPF10_uc021ouo.1_Intron|NBPF10_uc021oup.1_Intron|NBPF10_uc010oyp.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	1369										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGACTCACTGAATAGATGTTA	0.473000													4	39					0	0	1	0	0
TMEM223	79064	broad.mit.edu	37	11	62559255	62559255	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr11:62559255delG	uc001nve.2	-	0	232	c.212delC	c.(211-213)ccgfs	p.P71fs		NM_001080501	NP_001073970	A0PJW6	TM223_HUMAN	Homo sapiens transmembrane protein 223 (TMEM223), mRNA.	71						integral to membrane											CACCGGAACCGGGGGCCGGGA	0.706													2	4	---	---	---	---					
ALDH3B1	221	broad.mit.edu	37	11	67782802	67782802	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr11:67782802delG	uc010rpy.2	+	1	151	c.35delG	c.(34-36)cggfs	p.R12fs	ALDH3B1_uc001omy.1_Frame_Shift_Del_p.R12fs|ALDH3B1_uc001omz.3_Frame_Shift_Del_p.R12fs|ALDH3B1_uc001ona.3_Frame_Shift_Del_p.R12fs|ALDH3B1_uc001onb.3_5'Flank	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	Homo sapiens aldehyde dehydrogenase 3 family, member B1 (ALDH3B1), transcript variant 3, mRNA.	12					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CGGCGACTGCGGGAGGCCTTC	0.687													2	4	---	---	---	---					
ADAMTS7	11173	broad.mit.edu	37	15	79058183	79058184	+	Frame_Shift_Ins	INS	-	-	TGGGTCC			TCGA-FC-A66V-01A-21D-A30E-08	TCGA-FC-A66V-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0108ed61-8918-4ab9-b932-05cfd43ab22e	61d23977-669f-4308-8e10-682b9c3c969d	g.chr15:79058183_79058184insTGGGTCC	uc002bej.4	-	18	4280_4281	c.4069_4070insGGACCCA	c.(4069-4071)aagfs	p.K1357fs	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	1357					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						AGGCTGACCCTTGGGTCCTGGG	0.653													7	25	---	---	---	---					
