Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	C	T	rs55749440		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:207787753C>T	uc001hfy.3	+	31	5370	c.5230C>T	c.(5230-5232)Cga>Tga	p.R1744*	CR1_uc001hfx.3_Nonsense_Mutation_p.R2194*|CR1_uc021pij.1_Nonsense_Mutation_p.R1744*	NM_000573	NP_000564	P17927	CR1_HUMAN	Homo sapiens complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.	1744	Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1749*(9)|p.R2194*(9)|p.R1744*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTAGGTTCCGATTAAAAGG	0.423000													3	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412752	179412752	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr2:179412752A>G	uc021vsy.1	-	287	86122	c.85897T>C	c.(85897-85899)Ttc>Ctc	p.F28633L	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Missense_Mutation_p.F22328L|TTN_uc021vta.1_Missense_Mutation_p.F22261L|TTN_uc021vtb.1_Missense_Mutation_p.F22136L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	29560	Fibronectin type-III 108.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F22136L(2)|p.F22261L(1)|p.F28633L(1)|p.F28631L(1)|p.F22328L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAAGAGAAGGCTTCTCTG	0.443000													33	52					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489406	133489406	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr2:133489406C>A	uc002ttp.3	-	16	5721	c.5347G>T	c.(5347-5349)Gca>Tca	p.A1783S	NCKAP5_uc002ttq.3_Missense_Mutation_p.A464S	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Homo sapiens NCK-associated protein 5 (NCKAP5), transcript variant 1, mRNA.	1783							protein binding	p.A1783S(2)|p.A303S(1)		NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GCGCTATCTGCAGGGCGCTGG	0.582000													4	123					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:145302714A>G	uc021oul.1	+	7	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_uc021ots.1_Intron|NBPF10_uc010oye.2_Intron|NBPF10_uc021ouk.1_Silent_p.L384L|NBPF10_uc010oyi.2_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L|NBPF10_uc021oum.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	384								p.L384L(6)|p.L113L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													7	156					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409276	17409276	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:17409276G>A	uc001mna.3	-	0	931	c.363C>T	c.(361-363)ttC>ttT	p.F121F	KCNJ11_uc001mnb.4_Silent_p.F34F	NM_000525	NP_001159762	B4DWI4	B4DWI4_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), transcript variant 1, mRNA.	34						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.F121F(2)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TGGAGAAAAGGAAGGCAGACG	0.607000													8	41					0	0	1	0	0
ANKRD20A2	441430	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr2:95522786T>C	uc010fhp.3	-	0		c.35A>G						Q5SQ80	A20A2_HUMAN	Homo sapiens ankyrin repeat domain 20 family, member A8, pseudogene (ANKRD20A8P), non-coding RNA.									p.K44K(1)		large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	4						CGGCGTCGCCTTTGACAGCTG	0.687000													3	86					0	0	1	0	0
CCDC34	91057	broad.mit.edu	37	11	27379087	27379087	+	Splice_Site	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:27379087T>C	uc001mrh.1	-	2	414	c.360_splice	c.e2-1	p.S120_splice	CCDC34_uc001mri.1_Splice_Site_p.S120_splice	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	Homo sapiens coiled-coil domain containing 34 (CCDC34), transcript variant 1, mRNA.	120								p.T121A(2)		endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						TCAACCTGAGTGCTACAAAAG	0.398000													17	75					0	0	1	0	0
DENND2D	79961	broad.mit.edu	37	1	111737241	111737241	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:111737241G>A	uc001eak.1	-	6	953	c.753C>T	c.(751-753)gcC>gcT	p.A251A	DENND2D_uc001eal.1_Silent_p.A248A	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	Homo sapiens DENN/MADD domain containing 2D (DENND2D), mRNA.	251	DENN.							p.A251A(2)		breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TCTCCAGCACGGCAGAGGCAA	0.537000													13	55					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409274	17409274	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:17409274A>C	uc001mna.3	-	0	933	c.365T>G	c.(364-366)cTt>cGt	p.L122R	KCNJ11_uc001mnb.4_Missense_Mutation_p.L35R	NM_000525	NP_001159762	B4DWI4	B4DWI4_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), transcript variant 1, mRNA.	35						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.L122R(2)|p.F121F(1)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AATGGAGAAAAGGAAGGCAGA	0.607000													8	41					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48261786	48261786	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr16:48261786C>A	uc002eff.1	-	2	676	c.326G>T	c.(325-327)cGg>cTg	p.R109L	ABCC11_uc002efg.1_Missense_Mutation_p.R109L|ABCC11_uc002efh.1_Missense_Mutation_p.R109L|ABCC11_uc010vgl.1_Missense_Mutation_p.R109L	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (ABCC11), transcript variant 2, mRNA.	109						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.R109L(2)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TAAGCGACTCCGTAAGCTTTG	0.552000													3	125					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38821349	38821349	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:38821349C>A	uc002hvc.2	-	0	68	c.3G>T	c.(1-3)atG>atT	p.M1I	KRT222_uc002hvb.2_5'UTR|KRT222_uc010cxc.3_5'UTR	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	Homo sapiens keratin 222 (KRT222), mRNA.	1						intermediate filament	structural molecule activity	p.M1I(2)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						GGGACAGTTCCATTCTTTTCC	0.512000													4	125					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900753	123900753	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:123900753C>T	uc001pzp.1	+	0	424	c.424C>T	c.(424-426)Ctt>Ttt	p.L142F		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily G, member 8 (OR10G8), mRNA.	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L142F(2)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTCGTGTACTCTTCTGGCCAC	0.557000													6	152					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77170942	77170942	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr18:77170942C>A	uc010xfg.2	+	1	1120	c.667C>A	c.(667-669)Cgc>Agc	p.R223S	NFATC1_uc002lnc.1_Missense_Mutation_p.R223S|NFATC1_uc010xff.1_Missense_Mutation_p.R223S|NFATC1_uc002lnd.3_Missense_Mutation_p.R223S|NFATC1_uc002lne.3_Intron|NFATC1_uc010xfh.2_Missense_Mutation_p.R223S|NFATC1_uc010xfi.1_Missense_Mutation_p.R210S|NFATC1_uc010xfj.2_Intron|NFATC1_uc002lnf.3_Missense_Mutation_p.R210S|NFATC1_uc002lng.3_Missense_Mutation_p.R210S|NFATC1_uc010xfk.2_Missense_Mutation_p.R210S	NM_006162	NP_006153	O95644	NFAC1_HUMAN	Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 2, mRNA.	223	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.R210S(1)|p.R222R(1)		NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGGCTTTCCCCGCGGGCTGGG	0.711000													3	71					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978336	58978336	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:58978336A>C	uc001nnu.4	-	0	2159	c.2003T>G	c.(2002-2004)cTg>cGg	p.L668R		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.	668						integral to membrane		p.L668R(2)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				AACAACAGCCAGAATGGTGGT	0.557000													32	79					0	0	1	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	A	G	rs12107841	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr3:195400728A>G	uc003fuw.3	+	8	1218	c.24A>G	c.(22-24)ccA>ccG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_Non-coding_Transcript|SDHAP2_uc003fuv.3_Non-coding_Transcript					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2 (SDHAP2), non-coding RNA.																		GATTGTGCCCAGCCTGTACGC	0.587000													3	24					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32093899	32093899	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:32093899G>T	uc003nzn.3	-	4	506	c.473C>A	c.(472-474)tCc>tAc	p.S158Y	ATF6B_uc003nzo.3_Missense_Mutation_p.S155Y|ATF6B_uc011dpg.2_Missense_Mutation_p.S92Y|ATF6B_uc011dph.2_Missense_Mutation_p.S158Y	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	Homo sapiens activating transcription factor 6 beta (ATF6B), transcript variant 1, mRNA.	158					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S158Y(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						ATTACCTGAGGAATCATCAGA	0.507000													42	81					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128983512	128983512	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr5:128983512G>A	uc003kvb.1	+	11	1909	c.1909G>A	c.(1909-1911)Gga>Aga	p.G637R	ADAMTS19_uc010jdh.1_Non-coding_Transcript	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19), mRNA.	637	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G637R(3)|p.A636A(1)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATCTGGCCGGAGAGTGGAG	0.522000													55	27					0	0	1	0	0
FOXC1	2296	broad.mit.edu	37	6	1611154	1611154	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:1611154C>T	uc003mtp.3	+	0	474	c.474C>T	c.(472-474)tcC>tcT	p.S158S		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	Homo sapiens forkhead box C1 (FOXC1), mRNA.	158					Notch signaling pathway|anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	DNA bending activity|chromatin DNA binding|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.S158S(3)		large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		ACCCGGACTCCTACAACATGT	0.627000													8	38					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31752254	31752254	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:31752254C>T	uc003nxe.3	-	11	1916	c.1493G>A	c.(1492-1494)cGc>cAc	p.R498H	VARS_uc011doi.1_Non-coding_Transcript	NM_006295	NP_006286	P26640	SYVC_HUMAN	Homo sapiens valyl-tRNA synthetase (VARS), nuclear gene encoding mitochondrial protein, mRNA.	498					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity	p.R498H(4)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GAGCAGGGTGCGACCTGTCAG	0.597000													25	56					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436911	66436911	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr16:66436911G>A	uc002eom.4	+	11	2350	c.2194G>A	c.(2194-2196)Ggc>Agc	p.G732S		NM_001795	NP_001786	P33151	CADH5_HUMAN	Homo sapiens cadherin 5, type 2 (vascular endothelium) (CDH5), mRNA.	732					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding	p.G732S(2)		central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GCACATCTACGGCTACGAGGG	0.642000													11	19					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67052768	67052768	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:67052768G>A	uc009yrn.1	+	20	2183	c.1917G>A	c.(1915-1917)gaG>gaA	p.E639E		NM_001619	NP_001610	P25098	ARBK1_HUMAN	Homo sapiens adrenergic, beta, receptor kinase 1 (ADRBK1), mRNA.	639	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	ATP binding|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|alpha-2A adrenergic receptor binding|beta-adrenergic receptor kinase activity|signal transducer activity	p.E639E(3)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGACCCTGAGCTGGTGCAGT	0.697000													21	31					0	0	1	0	0
APCDD1L	164284	broad.mit.edu	37	20	57036031	57036031	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr20:57036031G>T	uc010zzp.1	-	4	1678	c.1354C>A	c.(1354-1356)Cca>Aca	p.P452T	APCDD1L_uc002xze.1_Missense_Mutation_p.P441T	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	Homo sapiens adenomatosis polyposis coli down-regulated 1-like (APCDD1L), mRNA.	441						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CGTTTCTCTGGGGTATCGGGA	0.602000													4	136					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113544983	113544983	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr12:113544983G>T	uc001tun.2	-	15	1880	c.1579C>A	c.(1579-1581)Ccc>Acc	p.P527T	RASAL1_uc010syp.2_Missense_Mutation_p.P526T|RASAL1_uc001tul.3_Missense_Mutation_p.P526T|RASAL1_uc001tum.2_Missense_Mutation_p.P526T|RASAL1_uc010syq.2_Missense_Mutation_p.P526T|RASAL1_uc001tuo.4_Missense_Mutation_p.P526T|RASAL1_uc010syr.2_3'UTR	NM_001193520	NP_001180449	O95294	RASL1_HUMAN	Homo sapiens RAS protein activator like 1 (GAP1 like) (RASAL1), transcript variant 1, mRNA.	526					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|metal ion binding|phospholipid binding	p.P526T(3)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GGGTGCAGGGGGGCCATCCAC	0.622000													18	30					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95718641	95718641	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:95718641C>T	uc009xuj.2	-	0	3032	c.2513G>A	c.(2512-2514)cGa>cAa	p.R838Q						Homo sapiens PIP5K1A and PSMD4-like, pseudogene (PIPSL), non-coding RNA.																		CACAGCATTTCGAATGGCTTC	0.542000													10	62					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496622	20496622	+	RNA	SNP	A	A	T	rs2601530	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:20496622A>T	uc001ytf.1	+	5		c.675A>T								Homo sapiens checkpoint kinase 2 pseudogene 2 (CHEK2P2), non-coding RNA.																		AAGTGGCCTCATGAAGGGGAA	0.438000													18	133					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117666	117666	+	RNA	SNP	G	G	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chrGL000205.1:117666G>C	uc002kgk.4	+	0		c.1044G>C								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		CGCGAGTTCAGAGCGTGGAGC	0.612000													3	17					0	0	1	0	0
abParts	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:22663087A>G	uc021wml.1	+	30		c.2445A>G			abParts_uc011aiq.1_Non-coding_Transcript|abParts_uc011aip.2_Non-coding_Transcript|abParts_uc010gto.3_Non-coding_Transcript					Parts of antibodies, mostly variable regions.																		GCTGCCACATAAGTTGTCCTT	0.303000													3	46					0	0	1	0	0
RRP7B	91695	broad.mit.edu	37	22	42971987	42971987	+	RNA	SNP	T	T	C	rs137064	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:42971987T>C	uc003bcs.3	-	5		c.707A>G			RRP7B_uc003bct.3_Non-coding_Transcript					Homo sapiens ribosomal RNA processing 7 homolog B (S. cerevisiae) (RRP7B), non-coding RNA.									p.Q59R(1)									CAGCTCTTTTTGGCTGCGCTT	0.672000													3	23					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3077128	3077128	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:3077128A>G	uc010jni.3	+	1	303	c.71A>G	c.(70-72)gAc>gGc	p.D24G	RIPK1_uc003muv.4_5'UTR|RIPK1_uc003mux.3_Missense_Mutation_p.D24G|RIPK1_uc011dhs.2_Missense_Mutation_p.D24G	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mRNA.	24	Protein kinase.				MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|activation of JUN kinase activity|activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of anti-apoptosis|positive regulation of interleukin-8 production|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity	p.D24G(3)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCAGAACTGGACAGCGGAGGC	0.478000													8	49					0	0	1	0	0
PRKCSH	5589	broad.mit.edu	37	19	11552168	11552168	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr19:11552168A>G	uc010xlz.2	+	5	800	c.464A>G	c.(463-465)aAg>aGg	p.K155R	PRKCSH_uc002mrt.3_Missense_Mutation_p.K155R|PRKCSH_uc002mru.3_Missense_Mutation_p.K155R|PRKCSH_uc002mrv.1_Missense_Mutation_p.K155R|PRKCSH_uc010dyb.3_Missense_Mutation_p.K155R	NM_002743	NP_002734	P14314	GLU2B_HUMAN	Homo sapiens protein kinase C substrate 80K-H (PRKCSH), transcript variant 1, mRNA.	155					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein N-linked glycosylation via asparagine|protein folding	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding	p.K155R(2)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						CGGGAGGAGAAGCAGGTAAGG	0.612000													52	113					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540359	187540359	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr4:187540359A>G	uc003izf.3	-	9	7569	c.7381T>C	c.(7381-7383)Tac>Cac	p.Y2461H		NM_005245	NP_005236	Q14517	FAT1_HUMAN	Homo sapiens FAT tumor suppressor homolog 1 (Drosophila) (FAT1), mRNA.	2461	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.Y2461H(3)|p.Y2464H(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTAAGACTGTAAAATGGCTTC	0.443000										HNSCC(5;0.00058)			6	234					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr20:33345744C>T	uc002xav.3	-	7	3378	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_uc002xaw.3_Silent_p.Q269Q|NCOA6_uc021wcd.1_Silent_p.Q269Q|NCOA6_uc021wce.1_Silent_p.Q269Q|NCOA6_uc021wcf.1_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	Homo sapiens nuclear receptor coactivator 6 (NCOA6), transcript variant 1, mRNA.	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				DNA recombination|DNA repair|DNA replication|brain development|cellular lipid metabolic process|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(29)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	55					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113529332	113529332	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr8:113529332C>T	uc003ynu.3	-	27	4846	c.4687G>A	c.(4687-4689)Gag>Aag	p.E1563K	CSMD3_uc003yns.3_Missense_Mutation_p.E835K|CSMD3_uc003ynt.3_Missense_Mutation_p.E1523K|CSMD3_uc011lhx.2_Missense_Mutation_p.E1459K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript variant a, mRNA.	1563	Sushi 8.					integral to membrane|plasma membrane		p.E1563K(2)|p.E1563V(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTCTTTCCTCTCCTTGAAGT	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	66					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28315754	28315754	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr21:28315754C>A	uc002ymg.3	-	2	2079	c.1350G>T	c.(1348-1350)aaG>aaT	p.K450N		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5), mRNA.	450	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding	p.K450N(3)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGGACCAGGGCTTAGATGCAT	0.448000													4	34					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8221715	8221715	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:8221715G>A	uc002glc.3	+	9	1870	c.1715G>A	c.(1714-1716)cGc>cAc	p.R572H	ARHGEF15_uc002gld.3_Missense_Mutation_p.R572H|ARHGEF15_uc010vuw.2_Missense_Mutation_p.R461H	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 15 (ARHGEF15), transcript variant 1, mRNA.	572	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.R572H(2)		breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AATATCCTGCGCCAGACAGAA	0.627000													47	84					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99500344	99500344	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:99500344C>A	uc002bul.3	+	20	3827	c.3777C>A	c.(3775-3777)ttC>ttA	p.F1259L	IGF1R_uc010bon.3_Missense_Mutation_p.F1258L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA.	1259	Protein kinase.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of DNA replication|positive regulation of cell migration|positive regulation of cell proliferation|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGCCTTCCTTCCTGGAGATCA	0.592000													4	97					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055355	75055355	+	Silent	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:75055355C>A	uc001dgg.3	-	11	2355	c.2136G>T	c.(2134-2136)gtG>gtT	p.V712V	CR627203_uc001dgh.3_Intron|C1orf173_uc001dgi.4_Silent_p.V506V	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	Homo sapiens chromosome 1 open reading frame 173 (C1orf173), mRNA.	712	Glu-rich.							p.V712V(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTTTGTCCTTCACCTGAGCAG	0.473000													6	217					0	0	1	0	0
SEPHS1	22929	broad.mit.edu	37	10	13375855	13375855	+	Silent	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:13375855T>C	uc001imk.3	-	4	899	c.522A>G	c.(520-522)ggA>ggG	p.G174G	SEPHS1_uc001imh.3_Silent_p.G98G|SEPHS1_uc010qbs.2_Silent_p.G126G|SEPHS1_uc010qbt.2_Silent_p.G107G|SEPHS1_uc021pnc.1_Silent_p.G174G|SEPHS1_uc021pnd.1_Silent_p.G174G|SEPHS1_uc009xje.3_Silent_p.G174G	NM_012247	NP_001182531	P49903	SPS1_HUMAN	Homo sapiens selenophosphate synthetase 1 (SEPHS1), transcript variant 1, mRNA.	174					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity	p.G174G(3)		cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						TGGTAGCCACTCCTCCCAGGA	0.438000													16	28					0	0	1	0	0
abParts	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:22663086T>G	uc021wml.1	+	30		c.2444T>G			abParts_uc011aiq.1_Non-coding_Transcript|abParts_uc011aip.2_Non-coding_Transcript|abParts_uc010gto.3_Non-coding_Transcript					Parts of antibodies, mostly variable regions.																		AGCTGCCACATAAGTTGTCCT	0.299000													3	46					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347071	48347071	+	Missense_Mutation	SNP	C	C	A	rs138317832		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:48347071C>A	uc010rhv.2	+	0	579	c.579C>A	c.(577-579)ttC>ttA	p.F193L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 3 (OR4C3), mRNA.	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F193L(2)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GGTTGCCCTTCTGTGGGCCCA	0.532000													23	63					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282589	59282589	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:59282589T>G	uc010rkv.2	+	0	204	c.204T>G	c.(202-204)atT>atG	p.I68M		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily D, member 9 (OR4D9), mRNA.	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I68M(2)		endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ACCTGTCTATTCTTGACATCT	0.443000													79	123					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117630	117630	+	RNA	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chrGL000205.1:117630G>A	uc002kgk.4	+	0		c.1008G>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GGAACAGGTCGCTGTACCAGG	0.602000													6	13					0	0	1	0	0
STARD3	10948	broad.mit.edu	37	17	37814071	37814071	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:37814071C>T	uc002hsd.3	+	3	544	c.341C>T	c.(340-342)gCc>gTc	p.A114V	STARD3_uc010weg.2_Missense_Mutation_p.A114V|STARD3_uc010wei.2_Missense_Mutation_p.A114V|STARD3_uc002hse.3_Missense_Mutation_p.A114V|STARD3_uc010weh.2_Non-coding_Transcript|STARD3_uc002hsf.3_5'UTR	NM_006804	NP_006795	Q14849	STAR3_HUMAN	Homo sapiens StAR-related lipid transfer (START) domain containing 3 (STARD3), transcript variant 1, mRNA.	114	MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity	p.A114V(2)		endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTAGGCTATGCCGTGCTGCGG	0.647000													4	90					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86838596	86838596	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:86838596G>A	uc002blz.1	+	15	2273	c.2193G>A	c.(2191-2193)acG>acA	p.T731T	AGBL1_uc002bma.1_Silent_p.T462T|AGBL1_uc002bmb.1_Silent_p.T425T	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	Homo sapiens ATP/GTP binding protein-like 1 (AGBL1), mRNA.	731					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.T731T(2)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGACCATCACGGCCATGCCTG	0.498000													37	68					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73615456	73615456	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:73615456G>T	uc002avp.3	-	7	3972	c.2978C>A	c.(2977-2979)aCg>aAg	p.T993K		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA.	993	Pro-rich.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity	p.T993K(2)		NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TGTCTCTGGCGTGCTCAGTGG	0.697000													7	13					0	0	1	0	0
DPT	1805	broad.mit.edu	37	1	168698284	168698284	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:168698284C>T	uc001gfp.3	-	0	159	c.129G>A	c.(127-129)cgG>cgA	p.R43R		NM_001937	NP_001928	Q07507	DERM_HUMAN	Homo sapiens dermatopontin (DPT), mRNA.	43	2 X 53-55 AA tandem repeats.				cell adhesion	extracellular space|proteinaceous extracellular matrix		p.R43R(3)		kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TGAAGCCTTGCCGGTTCAAAT	0.542000													4	64					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100177455	100177455	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:100177455G>A	uc021pwv.1	-	19	2215	c.1969C>T	c.(1969-1971)Cgc>Tgc	p.R657C	PYROXD2_uc001kpc.3_5'Flank|PYROXD2_uc010qpe.2_5'Flank	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Homo sapiens Hermansky-Pudlak syndrome 1 (HPS1), transcript variant 1, mRNA.	657					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity	p.R657C(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		TCGGTTGGGCGGTTCTTGCTG	0.662000									Hermansky-Pudlak syndrome				21	31					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195538675	195538675	+	Missense_Mutation	SNP	C	C	A	rs112836612	byFrequency	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr3:195538675C>A	uc021xjp.1	-	0	170	c.14G>T	c.(13-15)cGc>cTc	p.R5L	MUC4_uc003fvo.3_Missense_Mutation_p.R5L|MUC4_uc003fvp.3_Missense_Mutation_p.R5L|MUC4_uc010hzv.3_Non-coding_Transcript	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	5					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CCTCCTCCAGCGTGCCCCCTT	0.652000													3	29					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73498339	73498339	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr7:73498339T>G	uc003uaa.2	+	0	233	c.19T>G	c.(19-21)Tgt>Ggt	p.C7G	LIMK1_uc010lbl.2_Non-coding_Transcript	NM_002314	NP_002305	P53667	LIMK1_HUMAN	Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1, mRNA.	7					Rho protein signal transduction|actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				GACGCTACTTTGTTGCACCTG	0.776000													4	5					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21450761	21450761	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chrX:21450761C>A	uc004czx.2	+	2	740	c.260C>A	c.(259-261)aCc>aAc	p.T87N	CNKSR2_uc004czw.3_Missense_Mutation_p.T87N|CNKSR2_uc011mjn.2_Missense_Mutation_p.T87N|CNKSR2_uc011mjo.2_Missense_Mutation_p.T87N	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 1, mRNA.	87	CRIC.				regulation of signal transduction	cytoplasm|membrane	protein binding	p.T87N(4)		breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AATCTAAAAACCCTTTCTCAC	0.328000													7	76					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168278015	168278015	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:168278015G>C	uc001gfl.3	+	6	1003	c.952G>C	c.(952-954)Gtt>Ctt	p.V318L	TBX19_uc001gfj.4_Missense_Mutation_p.V186L|TBX19_uc001gfm.3_Missense_Mutation_p.V21L	NM_005149	NP_005140	O60806	TBX19_HUMAN	Homo sapiens T-box 19 (TBX19), mRNA.	318					anatomical structure morphogenesis	nucleus	DNA binding	p.V318L(2)		NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					TAATCTGCAAGTTTTCTCGGG	0.463000													3	92					0	0	1	0	0
