Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPN2	5771	broad.mit.edu	37	18	12802000	12802000	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr18:12802000T>C	uc002krp.3	-	7	1203	c.1009A>G	c.(1009-1011)Atg>Gtg	p.M337V	PTPN2_uc002krn.3_Missense_Mutation_p.M360V|PTPN2_uc002krl.3_Missense_Mutation_p.M337V|PTPN2_uc002krm.3_Missense_Mutation_p.M337V	NM_002828	NP_002819	P17706	PTN2_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1, mRNA.	337					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)|skin(3)	13		Lung NSC(161;8.94e-06)				GTATCTTGCATTTTAGAGGAA	0.348000													122	110					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533470	92533470	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr11:92533470T>C	uc001pdj.4	+	8	7308	c.7291T>C	c.(7291-7293)Tat>Cat	p.Y2431H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	Homo sapiens FAT tumor suppressor homolog 3 (Drosophila) (FAT3), mRNA.	2431	Cadherin 22.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCGGTTGGAATATAGCATTTT	0.478000										TCGA Ovarian(4;0.039)			45	60					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34067407	34067407	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr21:34067407T>G	uc002yqh.2	-	4	782	c.782A>C	c.(781-783)aAt>aCt	p.N261T	SYNJ1_uc011ads.1_Missense_Mutation_p.N222T|SYNJ1_uc002yqf.2_Missense_Mutation_p.N222T|SYNJ1_uc002yqg.2_Missense_Mutation_p.N222T|SYNJ1_uc002yqi.2_Missense_Mutation_p.N261T	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	Homo sapiens synaptojanin 1 (SYNJ1), transcript variant 1, mRNA.	222	SAC.						RNA binding|inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						ACCATCATCATTTGTTCCCCG	0.358000													48	80					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173330368	173330368	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:173330368C>A	uc002uhp.1	+	1	487	c.284C>A	c.(283-285)aCg>aAg	p.T95K	ITGA6_uc010fqk.1_5'UTR|ITGA6_uc010zdy.1_5'UTR|ITGA6_uc002uho.1_Missense_Mutation_p.T95K	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	Homo sapiens integrin, alpha 6 (ITGA6), transcript variant 1, mRNA.	95					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			GGGCCATGCACGCGGATCGAG	0.622000											OREG0015066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	17					0	0	1	0	0
ATP6V1A	523	broad.mit.edu	37	3	113507676	113507676	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:113507676G>T	uc003eao.3	+	6	941	c.833G>T	c.(832-834)gGt>gTt	p.G278V	ATP6V1A_uc011bik.2_Missense_Mutation_p.G245V	NM_001690	NP_001681	P38606	VATA_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (ATP6V1A), mRNA.	278					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTAGGATGTGGTGAAAGAGGA	0.418000													37	61					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51138473	51138473	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:51138473G>T	uc001rwv.3	+	37	4738	c.4582G>T	c.(4582-4584)Gaa>Taa	p.E1528*	DIP2B_uc009zlt.3_Nonsense_Mutation_p.E958*	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	Homo sapiens DIP2 disco-interacting protein 2 homolog B (Drosophila) (DIP2B), mRNA.	1528						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CGTGGTCCTGGAAGAGCATTA	0.547000													16	55					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33989021	33989021	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:33989021C>T	uc003ztq.1	-	4	505	c.392G>A	c.(391-393)gGa>gAa	p.G131E	UBAP2_uc011loc.1_Missense_Mutation_p.G93E|UBAP2_uc011lod.1_5'UTR|UBAP2_uc011loe.1_Intron|UBAP2_uc011lof.1_Missense_Mutation_p.G56E|UBAP2_uc011log.1_Missense_Mutation_p.G130E|UBAP2_uc003ztr.2_Missense_Mutation_p.G56E	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	Homo sapiens ubiquitin associated protein 2 (UBAP2), mRNA.	131										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GTTTCCACGTCCACGACTCGA	0.403000													6	183					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18023592	18023592	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:18023592C>A	uc001ban.3	+	28	3716	c.3557C>A	c.(3556-3558)cCg>cAg	p.P1186Q	ARHGEF10L_uc001bao.3_Missense_Mutation_p.P1147Q|ARHGEF10L_uc001bap.3_Missense_Mutation_p.P1142Q|ARHGEF10L_uc001baq.3_Missense_Mutation_p.P947Q|ARHGEF10L_uc010ocs.2_Missense_Mutation_p.P959Q|ARHGEF10L_uc001bar.3_Missense_Mutation_p.P889Q|ARHGEF10L_uc009vpf.3_Non-coding_Transcript|ARHGEF10L_uc001bas.3_Missense_Mutation_p.P210Q	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10-like (ARHGEF10L), transcript variant 1, mRNA.	1186					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CTCCCGGGCCCGCTGCTCTCC	0.677000													3	29					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5038269	5038269	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:5038269C>G	uc002cye.2	+	3	513	c.333C>G	c.(331-333)caC>caG	p.H111Q		NM_014692	NP_055507	O43304	S14L5_HUMAN	Homo sapiens SEC14-like 5 (S. cerevisiae) (SEC14L5), mRNA.	111	PRELI/MSF1.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGAACGAGCACTGCAGCTACA	0.632000													10	31					0	0	1	0	0
TRPV2	51393	broad.mit.edu	37	17	16321003	16321003	+	Silent	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:16321003T>C	uc002gpy.3	+	1	420	c.21T>C	c.(19-21)tcT>tcC	p.S7S	TRPV2_uc002gpz.3_5'UTR	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily V, member 2 (TRPV2), mRNA.	7	Required for interaction with SLC50A1 (By similarity).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCTCCAGCTCTCCAGTTTTCA	0.577000													3	76					0	0	1	0	0
RLBP1	6017	broad.mit.edu	37	15	89760395	89760395	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr15:89760395C>T	uc002bnl.3	-	4	682	c.302G>A	c.(301-303)cGc>cAc	p.R101H		NM_000326	NP_000317	P12271	RLBP1_HUMAN	Homo sapiens retinaldehyde binding protein 1 (RLBP1), mRNA.	101					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	CTTCCGTGCGCGGATGAAGCG	0.667000													22	35					0	0	1	0	0
CDK17	5128	broad.mit.edu	37	12	96677410	96677410	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:96677410C>T	uc001tep.2	-	13	1968	c.1336G>A	c.(1336-1338)Gga>Aga	p.G446R	CDK17_uc009ztk.3_Missense_Mutation_p.G446R|CDK17_uc010svb.2_Missense_Mutation_p.G393R	NM_002595	NP_002586	Q00537	CDK17_HUMAN	Homo sapiens cyclin-dependent kinase 17 (CDK17), transcript variant 1, mRNA.	446	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AACTCAATTCCTTCAGAGTCT	0.313000													6	95					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1844605	1844605	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:1844605A>C	uc003wpr.3	+	13	1725	c.1547A>C	c.(1546-1548)gAa>gCa	p.E516A	ARHGEF10_uc003wpq.1_Missense_Mutation_p.E541A|ARHGEF10_uc003wps.3_Missense_Mutation_p.E478A|ARHGEF10_uc003wpt.3_Missense_Mutation_p.E392A|ARHGEF10_uc003wpv.3_Missense_Mutation_p.E249A|ARHGEF10_uc010lre.3_Missense_Mutation_p.E196A	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10 (ARHGEF10), mRNA.	541	DH.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	Rho guanyl-nucleotide exchange factor activity|kinesin binding			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GCTTTTCTTGAATTTTTAAAG	0.388000													4	82					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29367179	29367179	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr15:29367179C>A	uc001zck.3	+	3	1211	c.1007C>A	c.(1006-1008)cCt>cAt	p.P336H	APBA2_uc010azj.2_Missense_Mutation_p.P336H|APBA2_uc010uat.2_Missense_Mutation_p.P336H|APBA2_uc001zcl.3_Missense_Mutation_p.P336H|APBA2_uc001zcm.1_Missense_Mutation_p.P40H	NM_005503	NP_005494	Q99767	APBA2_HUMAN	Homo sapiens amyloid beta (A4) precursor protein-binding, family A, member 2 (APBA2), transcript variant 1, mRNA.	336					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CTCAATGGACCTGTTGACAAT	0.453000													3	27					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42742922	42742922	+	Silent	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr13:42742922A>G	uc001uyl.2	+	10	1402	c.1335A>G	c.(1333-1335)aaA>aaG	p.K445K	DGKH_uc010tfh.2_Silent_p.K445K|DGKH_uc001uym.2_Silent_p.K445K|DGKH_uc001uyn.2_Non-coding_Transcript|DGKH_uc010tfi.2_Silent_p.K200K|DGKH_uc001uyo.2_Silent_p.K309K|DGKH_uc010tfj.2_Silent_p.K309K|DGKH_uc001uyp.3_Non-coding_Transcript	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	Homo sapiens diacylglycerol kinase, eta (DGKH), transcript variant 2, mRNA.	445	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TCCTAGAGAAACTGGAACGAG	0.423000													37	15					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88027604	88027604	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr5:88027604C>T	uc003kjl.3	-	8	1235	c.806G>A	c.(805-807)cGt>cAt	p.R269H	MEF2C_uc021ybg.1_Missense_Mutation_p.R203H|MEF2C_uc021ybh.1_Missense_Mutation_p.R203H|MEF2C_uc003kji.2_Missense_Mutation_p.R251H|MEF2C_uc003kjj.3_Missense_Mutation_p.R251H|MEF2C_uc003kjk.3_Missense_Mutation_p.R251H|MEF2C_uc003kjm.3_Missense_Mutation_p.R249H	NM_001193347	NP_001180276	Q06413	MEF2C_HUMAN	Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant 3, mRNA.	251					B cell proliferation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|apoptosis|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATCTGGTTTACGGTTATTCAT	0.388000										HNSCC(66;0.2)			19	30					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287673	16287673	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr22:16287673C>G	uc010gqp.2	-	0	265	c.213G>C	c.(211-213)tgG>tgC	p.W71C	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	Homo sapiens POTE ankyrin domain family, member H (POTEH), mRNA.	71								p.W71C(2)|p.P70T(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TCCCCCTGCACCAGGGGAAGC	0.582000													3	164					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080190	29080190	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:29080190C>A	uc011dll.2	+	0	523	c.523C>A	c.(523-525)Cgc>Agc	p.R175S		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily J, member 3 (OR2J3), mRNA.	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R175S(2)|p.H174N(1)		endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						GTGTGGACACCGCCAAGTAGA	0.488000													4	164					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750645	94750645	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:94750645A>G	uc003hta.1	+	0	568	c.568A>G	c.(568-570)Aac>Gac	p.N190D		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	Homo sapiens atonal homolog 1 (Drosophila) (ATOH1), mRNA.	190	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CCCGTCGTTCAACAACGACAA	0.577000													31	39					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813420	106813420	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:106813420C>T	uc003ymd.3	+	7	1133	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F	ZFPM2_uc011lhs.2_Silent_p.F101F	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	Homo sapiens zinc finger protein, multitype 2 (ZFPM2), mRNA.	370					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACTGCCATTTCGGCTTCCAGA	0.512000													9	196					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442221	103442221	+	Splice_Site	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:103442221T>G	uc001ymi.1	-	10	1619	c.1387_splice	c.e10+1	p.E463_splice		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	Homo sapiens CDC42 binding protein kinase beta (DMPK-like) (CDC42BPB), mRNA.	463					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGCCCTCACCTTGCAGCTTCC	0.662000													8	128					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46889635	46889635	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr11:46889635G>C	uc001ndn.4	-	33	5225	c.4982C>G	c.(4981-4983)gCt>gGt	p.A1661G	LOC100507401_uc001ndl.3_Intron	NM_002334	NP_002325	O75096	LRP4_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 4 (LRP4), mRNA.	1661					Wnt receptor signaling pathway|endocytosis|negative regulation of canonical Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATGCCAGTAGCCCTAGGAGC	0.537000													4	85					0	0	1	0	0
C9orf174	100499483	broad.mit.edu	37	9	100128910	100128910	+	Missense_Mutation	SNP	G	G	A	rs147885690		TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:100128910G>A	uc011lut.2	+	44	5672	c.4666G>A	c.(4666-4668)Gcc>Acc	p.A1556T	C9orf174_uc004axe.2_Missense_Mutation_p.A1362T|C9orf174_uc011lus.2_Missense_Mutation_p.A1143T|C9orf174_uc004axg.2_Missense_Mutation_p.A1417T|C9orf174_uc004axh.2_Non-coding_Transcript	NM_020893	NP_065944	Q9P1Z9	CI174_HUMAN	Homo sapiens chromosome 9 open reading frame 174 (C9orf174), mRNA.	1362						integral to membrane				breast(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(1)	16						TGACCAGTGCGCCGAGAACAT	0.532000													4	46					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56152862	56152862	+	Silent	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr15:56152862G>T	uc002adj.3	-	5	2346	c.2046C>A	c.(2044-2046)tcC>tcA	p.S682S	NEDD4_uc002adl.3_Silent_p.S263S|NEDD4_uc002adi.3_Silent_p.S610S|NEDD4_uc010ugj.2_Silent_p.S666S|NEDD4_uc010bfm.3_Silent_p.S665S|NEDD4_uc002adk.3_Non-coding_Transcript	NM_198400	NP_006145	P46934	NEDD4_HUMAN	Homo sapiens neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 2, mRNA.	682	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	RNA polymerase binding|beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CTTATACCTCGGAAGACTCTC	0.423000													4	121					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75516119	75516119	+	Silent	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:75516119C>A	uc001xrd.1	-	1	456	c.240G>T	c.(238-240)tcG>tcT	p.S80S	MLH3_uc001xre.1_Silent_p.S80S|MLH3_uc010tuy.1_Non-coding_Transcript	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	Homo sapiens mutL homolog 3 (E. coli) (MLH3), transcript variant 1, mRNA.	80					mismatch repair|reciprocal meiotic recombination	MutLbeta complex|chiasma|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		AGTCCTGTACCGAGTGGCATT	0.443000								Mismatch excision repair (MMR)					4	77					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103404601	103404601	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:103404601T>G	uc001dum.3	-	43	3782	c.3464A>C	c.(3463-3465)aAg>aCg	p.K1155T	COL11A1_uc001duk.3_Missense_Mutation_p.K339T|COL11A1_uc001dul.3_Missense_Mutation_p.K1143T|COL11A1_uc001dun.3_Missense_Mutation_p.K1104T|COL11A1_uc009weh.3_Missense_Mutation_p.K1027T	NM_080629	NP_542196	P12107	COBA1_HUMAN	Homo sapiens collagen, type XI, alpha 1 (COL11A1), transcript variant B, mRNA.	1143	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATTTTCTCCCTTGTCACCCTT	0.338000													4	63					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159409943	159409943	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:159409943A>G	uc010piv.2	+	0	432	c.395A>G	c.(394-396)gAc>gGc	p.D132G	BC038194_uc001fts.4_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily J, member 1 (OR10J1), mRNA.	132					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					ATGGGATATGACCGCTATGTG	0.498000													3	130					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101047392	101047392	+	Splice_Site	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:101047392T>C	uc003dut.3	-	22	2907	c.2796_splice	c.e22-1	p.R932_splice	SENP7_uc003duu.3_Splice_Site_p.R867_splice|SENP7_uc003duv.3_Splice_Site_p.R899_splice|SENP7_uc003duw.3_Splice_Site_p.R866_splice|SENP7_uc003dux.3_Splice_Site_p.R768_splice|SENP7_uc003dus.3_Splice_Site_p.R120_splice	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	Homo sapiens SUMO1/sentrin specific peptidase 7 (SENP7), transcript variant 1, mRNA.	932	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ATACATGGCCTATGAAAAGCA	0.318000													3	173					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763654	5763654	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:5763654G>T	uc003zjl.4	+	17	2707	c.2516G>T	c.(2515-2517)cGg>cTg	p.R839L	KIAA1432_uc003zjh.3_Missense_Mutation_p.R797L|KIAA1432_uc003zji.3_Missense_Mutation_p.R797L|KIAA1432_uc003zjj.1_Missense_Mutation_p.R339L	NM_001206557	NP_001193486	Q4ADV7	RIC1_HUMAN	Homo sapiens KIAA1432 (KIAA1432), transcript variant 3, mRNA.	876						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GCTACCTCACGGGAGCCCATT	0.532000													4	124					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117012	117012	+	RNA	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chrGL000205.1:117012C>A	uc002kgk.4	+	0		c.390C>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		ACCAAAGAAGCTGTATTCCCT	0.478000													3	5					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107824969	107824969	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:107824969G>A	uc003prx.3	+	1	709	c.205G>A	c.(205-207)Gag>Aag	p.E69K	SOBP_uc003prw.1_Missense_Mutation_p.E69K	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	Homo sapiens sine oculis binding protein homolog (Drosophila) (SOBP), mRNA.	69							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TACAGATGGGGAGAGCCGGCA	0.403000													6	94					0	0	1	0	0
TCAP	8557	broad.mit.edu	37	17	37821715	37821715	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:37821715G>A	uc002hsh.3	+	0	117	c.103G>A	c.(103-105)Gag>Aag	p.E35K	PNMT_uc002hsi.1_5'Flank	NM_003673	NP_003664	O15273	TELT_HUMAN	Homo sapiens titin-cap (telethonin) (TCAP), mRNA.	35					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	Z disc|cytosol	structural constituent of muscle|titin Z domain binding|titin binding	p.P34P(1)		kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CACACGGCCCGAGGAGGGGTG	0.617000													29	43					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389323	1389323	+	Missense_Mutation	SNP	G	G	A	rs71299249	byFrequency	TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:1389323G>A	uc003gdf.2	+	0	3984	c.1024G>A	c.(1024-1026)Gcc>Acc	p.A342T		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	Homo sapiens cysteine-rich PAK1 inhibitor (CRIPAK), mRNA.	342					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding	p.P341P(1)		NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGGAGTGCCCGCCTGCTCACA	0.667000													13	778					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78667056	78667056	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:78667056C>T	uc003dqe.2	-	26	4219	c.4011G>A	c.(4009-4011)gaG>gaA	p.E1337E	ROBO1_uc003dqc.2_Silent_p.E1237E|ROBO1_uc003dqd.2_Silent_p.E1292E|ROBO1_uc003dqb.2_Silent_p.E1298E|ROBO1_uc010hoh.2_Silent_p.E529E|ROBO1_uc011bgl.1_Silent_p.E909E	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	Homo sapiens roundabout, axon guidance receptor, homolog 1 (Drosophila) (ROBO1), transcript variant 1, mRNA.	1337					Roundabout signaling pathway|activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis	cell surface|cytoplasm|integral to plasma membrane	LRR domain binding|axon guidance receptor activity|identical protein binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TCTTGGCTACCTCCATGTCGG	0.547000													41	45					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86832491	86832491	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:86832491G>T	uc002srn.3	-	3	1524	c.533C>A	c.(532-534)cCa>cAa	p.P178Q	RNF103_uc010ytl.2_Intron|RNF103_uc002srm.3_Missense_Mutation_p.P39Q|RNF103_uc021vkg.1_Missense_Mutation_p.P174Q|BC066991_uc002sro.3_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	Homo sapiens ring finger protein 103 (RNF103), transcript variant 1, mRNA.	178					ER-associated protein catabolic process|central nervous system development	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						ACTTGTTTGTGGAACAGACAT	0.398000													4	104					0	0	1	0	0
SLC50A1	55974	broad.mit.edu	37	1	155110477	155110477	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:155110477C>T	uc001fhj.4	+	4	567	c.467C>T	c.(466-468)tCa>tTa	p.S156L	SLC50A1_uc001fhk.4_Missense_Mutation_p.S101L|SLC50A1_uc001fhl.4_Missense_Mutation_p.S102L	NM_018845	NP_061333	Q9BRV3	SWET1_HUMAN	Homo sapiens solute carrier family 50 (sugar transporter), member 1 (SLC50A1), transcript variant 1, mRNA.	156	Mediates interaction with TRPV2 (By similarity).|MtN3/slv 2.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						CAAACTAAATCAACCCAATGT	0.463000													56	62					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32053654	32053654	+	Silent	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:32053654C>A	uc003nzl.2	-	6	3223	c.3021G>T	c.(3019-3021)gtG>gtT	p.V1007V		NM_019105	NP_061978	P22105	TENX_HUMAN	Homo sapiens tenascin XB (TNXB), transcript variant XB, mRNA.	1094	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCCCTGGCAGCACTTCCTCAT	0.682000													5	109					0	0	1	0	0
ANKRD20A9P	284232	broad.mit.edu	37	13	19415655	19415655	+	RNA	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr13:19415655C>A	uc010tcj.1	-	0		c.30455G>T								Homo sapiens ankyrin repeat domain 20 family, member A9, pseudogene (ANKRD20A9P), non-coding RNA.																		ccaaacaaaacaaaaCAAAAC	0.398000													9	48					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68719844	68719844	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:68719844T>G	uc003hdq.3	-	2	256	c.191A>C	c.(190-192)cAg>cCg	p.Q64P	LOC550112_uc003hdl.4_Intron|TMPRSS11D_uc011caj.2_5'UTR	NM_004262	NP_004253	O60235	TM11D_HUMAN	Homo sapiens transmembrane protease, serine 11D (TMPRSS11D), mRNA.	64	SEA.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.Q64*(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TGAATTTAACTGACTATTATA	0.303000													6	79					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21726417	21726417	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:21726417G>A	uc002djh.3	+	12	1433	c.1432G>A	c.(1432-1434)Gtc>Atc	p.V478I	LOC23117_uc021tel.1_Intron|OTOA_uc010vbj.2_Missense_Mutation_p.V399I|OTOA_uc002dji.3_Missense_Mutation_p.V154I|OTOA_uc010vbk.2_Missense_Mutation_p.V126I	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	Homo sapiens otoancorin (OTOA), transcript variant 1, mRNA.	492					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix		p.V478I(2)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GAGAAGTGCCGTCTCCCAGTA	0.577000													18	252					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55848836	55848836	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:55848836G>A	uc001xbx.2	-	5	757	c.721C>T	c.(721-723)Cgg>Tgg	p.R241W	FBXO34_uc001xbv.3_Intron|ATG14_uc001xbw.2_Missense_Mutation_p.R128W	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Homo sapiens ATG14 autophagy related 14 homolog (S. cerevisiae) (ATG14), mRNA.	241					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding	p.R241L(1)|p.A240D(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						GTTGTCCTCCGGGCTTCAGCA	0.527000													56	62					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1542704	1542704	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr7:1542704G>A	uc003skn.2	-	2	283	c.182C>T	c.(181-183)gCg>gTg	p.A61V	INTS1_uc003skq.2_Missense_Mutation_p.A61V	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	Homo sapiens integrator complex subunit 1 (INTS1), mRNA.	61	Poly-Ala.				snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CGCGGCCGCCGCATCCCGCTT	0.657000													5	110					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42264750	42264750	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr22:42264750C>A	uc003bbi.3	+	2	843	c.674C>A	c.(673-675)cCg>cAg	p.P225Q	bK250D10.C22.8_uc003bba.1_Intron|SREBF2_uc003bbj.3_5'Flank	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	Homo sapiens sterol regulatory element binding transcription factor 2 (SREBF2), mRNA.	225	Gln-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|SREBP-SCAP-Insig complex|nucleus	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ACCCTTGCCCCGGCTACGGTG	0.622000													3	43					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696432	47696432	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:47696432A>C	uc002ipg.3	-	4	688	c.391T>G	c.(391-393)Tgg>Ggg	p.W131G	SPOP_uc010dbk.3_Missense_Mutation_p.W131G|SPOP_uc002ipb.3_Missense_Mutation_p.W131G|SPOP_uc002ipc.3_Missense_Mutation_p.W131G|SPOP_uc002ipd.3_Missense_Mutation_p.W131G|SPOP_uc002ipe.3_Missense_Mutation_p.W131G|SPOP_uc002ipf.3_Missense_Mutation_p.W131G	NM_001007228	NP_003554	O43791	SPOP_HUMAN	Homo sapiens speckle-type POZ protein (SPOP), transcript variant 4, mRNA.	131	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.W131G(4)|p.W131R(2)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTGAATCCCCAGTCTTTGCCT	0.458000										Prostate(2;0.17)			79	106					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57864192	57864192	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:57864192C>T	uc001snx.3	+	11	1763	c.1669C>T	c.(1669-1671)Cgc>Tgc	p.R557C	GLI1_uc021qzi.1_Missense_Mutation_p.R516C|GLI1_uc009zpq.3_Missense_Mutation_p.R429C	NM_005269	NP_001153517	P08151	GLI1_HUMAN	Homo sapiens GLI family zinc finger 1 (GLI1), transcript variant 1, mRNA.	557					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TACTGTCAGCCGCCGCTCCTC	0.647000													43	74					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113122826	113122826	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:113122826C>A	uc003ead.2	-	8	1110	c.1043G>T	c.(1042-1044)tGg>tTg	p.W348L	WDR52_uc003eae.2_Missense_Mutation_p.W348L	NM_001164496	NP_001157968	Q96MT7	WDR52_HUMAN	Homo sapiens WD repeat domain 52 (WDR52), transcript variant 1, mRNA.	348										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						ACCACCTTCCCAAAGCAGCAT	0.453000													5	195					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	6995922	6995922	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:6995922C>T	uc011bwg.2	+	3	934	c.855C>T	c.(853-855)gaC>gaT	p.D285D	TBC1D14_uc003gjs.4_Silent_p.D285D|TBC1D14_uc010idh.3_Silent_p.D5D	NM_001113361	NP_065824	Q9P2M4	TBC14_HUMAN	Homo sapiens TBC1 domain family, member 14 (TBC1D14), transcript variant 2, mRNA.	285						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						aatatgaagacaaggctggaa	0.458000													8	94					0	0	1	0	0
RP9	6100	broad.mit.edu	37	7	33138944	33138944	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr7:33138944C>T	uc003tdm.3	-	2	306	c.288G>A	c.(286-288)ctG>ctA	p.L96L		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	Homo sapiens retinitis pigmentosa 9 (autosomal dominant) (RP9), mRNA.	96	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding	p.P95S(1)		large_intestine(3)|lung(3)|urinary_tract(1)	7			GBM - Glioblastoma multiforme(11;0.0403)			CTTCTTTCCCCAGTGGCATCC	0.428000													4	151					0	0	1	0	0
TGFA	7039	broad.mit.edu	37	2	70680366	70680366	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:70680366G>A	uc002sgs.4	-	4	707	c.459C>T	c.(457-459)tgC>tgT	p.C153C	TGFA_uc010fdq.3_Silent_p.C159C|TGFA_uc010fdr.3_Silent_p.C158C|TGFA_uc002sgt.4_Silent_p.C152C|TGFA_uc002sgu.3_Silent_p.C152C|TGFA_uc002sgv.3_Silent_p.C153C|TGFA_uc002sgw.3_Silent_p.C152C|Mir_548_uc021vjb.1_5'Flank	NM_003236	NP_003227	P01135	TGFA_HUMAN	Homo sapiens transforming growth factor, alpha (TGFA), transcript variant 1, mRNA.	153					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	MAP kinase kinase activity|epidermal growth factor receptor binding|growth factor activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|lung(2)|prostate(1)	4						CTGAGTGGCAGCAAGCGGTTC	0.577000													4	171					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131395	72131395	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:72131395G>A	uc004ahh.2	-	1	1008	c.732C>T	c.(730-732)ggC>ggT	p.G244G		NM_001163	NP_001154	Q02410	APBA1_HUMAN	Homo sapiens amyloid beta (A4) precursor protein-binding, family A, member 1 (APBA1), mRNA.	244	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						TGTCGGACTCGCCGTCGGAGC	0.701000													24	23					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7808017	7808017	+	Splice_Site	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:7808017G>T	uc001ijt.3	-	9	943	c.849_splice	c.e9+1	p.P283_splice	KIN_uc010qaz.2_Splice_Site|KIN_uc010qba.2_Splice_Site_p.P177_splice	NM_012311	NP_036443	O60870	KIN17_HUMAN	Homo sapiens KIN, antigenic determinant of recA protein homolog (mouse) (KIN), transcript variant 1, mRNA.	283					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	RNA binding|double-stranded DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AATACTTACAGGCTGTAGCCA	0.328000													11	42					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35632112	35632112	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr20:35632112G>T	uc002xgi.3	-	20	3108	c.3029C>A	c.(3028-3030)cCt>cAt	p.P1010H	RBL1_uc002xgj.1_Missense_Mutation_p.P1010H|FKSG51_uc021wda.1_5'Flank	NM_002895	NP_002886	P28749	RBL1_HUMAN	Homo sapiens retinoblastoma-like 1 (p107) (RBL1), transcript variant 1, mRNA.	1010					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				TACCTTAGAAGGGCTGCCATT	0.428000													4	109					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66753620	66753620	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:66753620G>A	uc003xvq.3	-	0	350	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	PDE7A_uc003xvr.3_Missense_Mutation_p.R42W	NM_001242318	NP_001229247	Q13946	PDE7A_HUMAN	Homo sapiens phosphodiesterase 7A (PDE7A), transcript variant 3, mRNA.	42						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GAGAGCTGCCGGGGATTGGGG	0.657000													17	32					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44171919	44171919	+	Silent	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chrX:44171919T>C	uc004dgb.4	-	1	215	c.126A>G	c.(124-126)ggA>ggG	p.G42G		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	Homo sapiens EF-hand domain (C-terminal) containing 2 (EFHC2), mRNA.	42							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						CTCCACCTATTCCAGGCTTTT	0.418000													24	2					0	0	1	0	0
CLUAP1	23059	broad.mit.edu	37	16	3570006	3570006	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:3570006G>T	uc002cvk.1	+	6	788	c.683G>T	c.(682-684)cGg>cTg	p.R228L	CLUAP1_uc002cvj.1_Missense_Mutation_p.R228L|CLUAP1_uc002cvm.1_Missense_Mutation_p.R62L|CLUAP1_uc021tcg.1_5'UTR	NM_015041	NP_079069	Q96AJ1	CLUA1_HUMAN	Homo sapiens clusterin associated protein 1 (CLUAP1), transcript variant 1, mRNA.	228						nucleus	protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(2)	16						GAAAGAAATCGGAAGCGACTA	0.423000													4	101					0	0	1	0	0
SLC18B1	116843	broad.mit.edu	37	6	133118163	133118163	+	Silent	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:133118163G>T	uc003qdw.1	-	1	293	c.141C>A	c.(139-141)tcC>tcA	p.S47S	SLC18B1_uc011eco.1_5'UTR	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	Homo sapiens chromosome 6 open reading frame 192 (C6orf192), mRNA.	47					transmembrane transport	integral to membrane											AGCACATCATGGAACCTAAGT	0.423000													4	137					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11090273	11090273	+	Silent	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:11090273C>A	uc001aru.3	-	9	1289	c.1257G>T	c.(1255-1257)acG>acT	p.T419T		NM_006610	NP_006601	O00187	MASP2_HUMAN	Homo sapiens mannan-binding lectin serine peptidase 2 (MASP2), transcript variant 1, mRNA.	419	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CTTTGGAGCTCGTCCAGAATC	0.403000													3	62					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262103	39262103	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:39262103A>T	uc010wfp.2	+	0	463	c.463A>T	c.(463-465)Agc>Tgc	p.S155C		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	Homo sapiens keratin associated protein 4-9 (KRTAP4-9), mRNA.	155	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						ccccagctgcagcatctccag	0.672000													3	18					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238243486	238243486	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:238243486G>A	uc002vwl.2	-	40	9297	c.9012C>T	c.(9010-9012)agC>agT	p.S3004S	COL6A3_uc002vwo.2_Silent_p.S2798S|COL6A3_uc010znj.1_Silent_p.S2397S|COL6A3_uc002vwj.2_Silent_p.S385S	NM_004369	NP_004360	P12111	CO6A3_HUMAN	Homo sapiens collagen, type VI, alpha 3 (COL6A3), transcript variant 1, mRNA.	3004	Fibronectin type-III.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAGTTTGGCGCTGTTCTCTG	0.483000													13	90					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6069654	6069654	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr20:6069654C>A	uc002wmr.3	-	9	2011	c.1222G>T	c.(1222-1224)Gaa>Taa	p.E408*	FERMT1_uc002wmq.3_5'UTR|FERMT1_uc010gbt.3_Nonsense_Mutation_p.E151*|FERMT1_uc002wms.3_Nonsense_Mutation_p.E408*	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	Homo sapiens fermitin family member 1 (FERMT1), mRNA.	408	FERM.|PH.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TGTTCAAGTTCCTTATTTTTA	0.383000													4	107					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88232463	88232463	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:88232463G>A	uc001kdn.3	-	6	1919	c.1910C>T	c.(1909-1911)gCa>gTa	p.A637V	WAPAL_uc009xsv.3_5'Flank|WAPAL_uc001kdo.3_Missense_Mutation_p.A600V|WAPAL_uc009xsw.3_Missense_Mutation_p.A594V	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	Homo sapiens wings apart-like homolog (Drosophila) (WAPAL), mRNA.	600	Mediates interaction with the cohesin complex.|WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of DNA replication|negative regulation of chromatin binding|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						GGATGGTGGTGCAGGAGCCTT	0.358000													36	28					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9780269	9780269	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:9780269C>A	uc001aqe.4	+	9	1542	c.1334C>A	c.(1333-1335)cCg>cAg	p.P445Q	PIK3CD_uc001aqb.4_Missense_Mutation_p.P480Q|PIK3CD_uc010oaf.2_Missense_Mutation_p.P480Q|PIK3CD_uc021ogb.1_Missense_Mutation_p.P264Q	NM_005026	NP_005017	O00329	PK3CD_HUMAN	Homo sapiens phosphoinositide-3-kinase, catalytic, delta polypeptide (PIK3CD), mRNA.	480					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GAGGTGGCCCCGCACCCCGTG	0.706000													3	48					0	0	1	0	0
SPINK1	6690	broad.mit.edu	37	5	147204248	147204250	+	In_Frame_Del	DEL	GAG	-	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr5:147204248_147204250delGAG	uc003los.2	-	3	334_336	c.214_216delCTC	c.(214-216)ctcdel	p.L72del		NM_003122	NP_003113	P00995	ISK1_HUMAN	Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA.	72	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			endometrium(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTTTGAATGAGGATAGAAGTC	0.399									Hereditary Pancreatitis				8	85	---	---	---	---					
CC2D2B	387707	broad.mit.edu	37	10	97779073	97779076	+	Frame_Shift_Del	DEL	TTGT	-	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:97779073_97779076delTTGT	uc010qop.2	+	7	868_871	c.636_639delTTGT	c.(634-639)gattgtfs	p.D212fs	LOC728558_uc001klg.2_Intron|LOC728558_uc001klj.2_Intron|CC2D2B_uc001klk.3_Intron|CC2D2B_uc001kll.3_Frame_Shift_Del_p.D212fs	NM_001159747	NP_001153219	Q6DHV5	C2D2B_HUMAN	Homo sapiens coiled-coil and C2 domain containing 2B (CC2D2B), transcript variant 1, mRNA.	212										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AAAGTGTAGATTGTTTGTTTGATG	0.363													9	130	---	---	---	---					
INSM2	84684	broad.mit.edu	37	14	36003785	36003785	+	Frame_Shift_Del	DEL	C	-	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:36003785delC	uc001wth.1	+	0	538	c.327delC	c.(325-327)agcfs	p.S109fs		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	Homo sapiens insulinoma-associated 2 (INSM2), mRNA.	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	10	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		ccagccccagccccagtccAG	0.781													3	5	---	---	---	---					
