Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SERPINB5	5268	broad.mit.edu	37	18	61160285	61160285	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr18:61160285T>C	uc002liz.4	+	4	666	c.524T>C	c.(523-525)tTt>tCt	p.F175S	SERPINB5_uc002liy.2_Missense_Mutation_p.F175S	NM_002639	NP_002630	P36952	SPB5_HUMAN	Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 5 (SERPINB5), mRNA.	175					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						ATGAAGAAATTTTCTGAATCA	0.403000													29	99					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43205697	43205697	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr18:43205697T>A	uc002lbe.3	+	2	1016	c.200T>A	c.(199-201)cTc>cAc	p.L67H	SLC14A2_uc002lbb.3_Missense_Mutation_p.L67H|SLC14A2_uc010dnj.3_Missense_Mutation_p.L67H	NM_007163	NP_009094	Q15849	UT2_HUMAN	Homo sapiens solute carrier family 14 (urea transporter), member 2 (SLC14A2), transcript variant 1, mRNA.	67						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATCGAAAAGCTCAATGAAAGG	0.502000													4	15					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63453881	63453881	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr14:63453881G>T	uc001xfx.3	-	4	509	c.458C>A	c.(457-459)aCa>aAa	p.T153K	KCNH5_uc001xfy.3_Missense_Mutation_p.T153K|KCNH5_uc001xfz.1_Missense_Mutation_p.T95K|KCNH5_uc001xga.3_Missense_Mutation_p.T95K	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 5 (KCNH5), transcript variant 1, mRNA.	153					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CAAAGCCCGTGTCAATCGGGC	0.378000													10	60					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419263	55419263	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:55419263C>A	uc001nhs.1	+	0	884	c.884C>A	c.(883-885)gCa>gAa	p.A295E		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily S, member 2 (OR4S2), mRNA.	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GTAAAGAATGCAATGAAGAAA	0.363000													13	217					0	0	1	0	0
TSPY2	64591	broad.mit.edu	37	Y	6114373	6114373	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chrY:6114373G>A	uc004fqr.1	+	0	110	c.64G>A	c.(64-66)Gtg>Atg	p.V22M	TTTY23_uc004fqq.1_5'Flank|TSPY2_uc004fqs.1_Missense_Mutation_p.V22M	NM_022573	NP_072095	A6NKD2	TSPY2_HUMAN	Homo sapiens testis specific protein, Y-linked 2 (TSPY2), mRNA.	22					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus		p.V22L(2)		liver(1)|lung(4)|prostate(1)|skin(1)	7						TTCCTGTGGCGTGGGTCGGGC	0.711000													11	20					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681387	142681387	+	Silent	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr3:142681387G>A	uc003evg.3	-	0	792	c.792C>T	c.(790-792)ttC>ttT	p.F264F	PAQR9_uc003evf.1_Non-coding_Transcript	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	Homo sapiens progestin and adipoQ receptor family member IX (PAQR9), mRNA.	264						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						CACGCAGGTCGAAGAGCCAGC	0.622000													4	84					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6387480	6387480	+	Silent	SNP	G	G	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:6387480G>C	uc002meq.2	-	4	702	c.417C>G	c.(415-417)ccC>ccG	p.P139P	GTF2F1_uc010xjb.1_5'UTR|GTF2F1_uc010xjc.1_Intron	NM_002096	NP_002087	P35269	T2FA_HUMAN	Homo sapiens general transcription factor IIF, polypeptide 1, 74kDa (GTF2F1), mRNA.	139					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	DNA binding|catalytic activity|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						AGTTGTGCACGGGGAAGGCCT	0.627000													11	80					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978841	58978841	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:58978841C>T	uc001nnu.4	-	0	1654	c.1498G>A	c.(1498-1500)Ggc>Agc	p.G500S		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	Homo sapiens macrophage expressed 1 (MPEG1), mRNA.	500						integral to membrane		p.A499G(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GGAAAGTAGCCGGCTGGGCAT	0.512000													9	89					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480545	10480545	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr8:10480545C>T	uc003wtc.3	-	1	396	c.167G>A	c.(166-168)cGc>cAc	p.R56H		NM_178857	NP_849188	A6NKC6	A6NKC6_HUMAN	Homo sapiens retinitis pigmentosa 1-like 1 (RP1L1), mRNA.	56					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTTAAAGGCGCGCTGGTGAAC	0.652000													10	68					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904093	21904093	+	RNA	SNP	A	A	G	rs76302591		TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:21904093A>G	uc002gza.2	+	0		c.32A>G								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		cacggggtccacaggaacgtc	0.682000													4	31					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47278910	47278910	+	Silent	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr2:47278910C>T	uc010fbb.3	+	18	2483	c.2115C>T	c.(2113-2115)gcC>gcT	p.A705A	TTC7A_uc002rvm.3_Silent_p.A647A|TTC7A_uc002rvo.3_Silent_p.A681A|TTC7A_uc010fbc.3_Silent_p.A327A|TTC7A_uc002rvp.3_Silent_p.A562A|TTC7A_uc002rvq.3_Silent_p.A421A|TTC7A_uc002rvr.3_Silent_p.A130A	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	Homo sapiens tetratricopeptide repeat domain 7A (TTC7A), mRNA.	681							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CGTCCATCGCCGCCTCCCGGC	0.657000													16	57					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145629382	145629382	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr4:145629382C>A	uc003ijs.2	+	6	1900	c.1220C>A	c.(1219-1221)tCc>tAc	p.S407Y		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	Homo sapiens hedgehog interacting protein (HHIP), mRNA.	407						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GTGCCTTATTCCATACCAAGG	0.507000													8	59					0	0	1	0	0
DIO1	1733	broad.mit.edu	37	1	54360027	54360027	+	Silent	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr1:54360027G>A	uc021onq.1	+	0	167	c.144G>A	c.(142-144)acG>acA	p.T48T	DIO1_uc021onp.1_Splice_Site_p.G49_splice|DIO1_uc009vzl.3_Silent_p.T48T|DIO1_uc001cwb.3_Silent_p.T48T|DIO1_uc021onr.1_Silent_p.T48T|DIO1_uc001cwd.3_Splice_Site|DIO1_uc001cwe.3_Splice_Site|DIO1_uc001cwf.3_Non-coding_Transcript|DIO1_uc001cwg.3_Non-coding_Transcript	NM_000792	NP_001034804	P49895	IOD1_HUMAN	Homo sapiens deiodinase, iodothyronine, type I (DIO1), transcript variant 1, mRNA.	48					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(2)|skin(1)	9						GCGAGAAGACGGGTATGACCA	0.527000													14	64					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249309	61249309	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:61249309G>A	uc001nru.2	+	1	160	c.28G>A	c.(28-30)Gtc>Atc	p.V10I	PPP1R32_uc009ynq.2_Missense_Mutation_p.V10I	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 32 (PPP1R32), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	10																	CCTGGGGGTCGTCTCCCCTTA	0.632000													3	29					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959779	38959779	+	Splice_Site	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:38959779C>T	uc002oit.3	+	26	3686	c.3556_splice	c.e26+1	p.G1186_splice	RYR1_uc002oiu.3_Splice_Site_p.G1186_splice	NM_000540	NP_000531	P21817	RYR1_HUMAN	Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 1, mRNA.	1186	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	I band|cell cortex|cytosol|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGATTGGGGACGGTGAGGGCT	0.557000													5	57					0	0	1	0	0
CCDC144B	284047	broad.mit.edu	37	17	18528485	18528485	+	Silent	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:18528485G>A	uc002guc.2	-	0	446	c.276C>T	c.(274-276)gaC>gaT	p.D92D	CCDC144B_uc002gua.4_Non-coding_Transcript|CCDC144B_uc010vyc.2_Non-coding_Transcript					Homo sapiens coiled-coil domain containing 144B (pseudogene) (CCDC144B), non-coding RNA.											NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(6)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	36						CCCCAGGGACGTCGCCCGACC	0.652000													12	162					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103623	53103623	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr7:53103623G>A	uc003tpz.3	+	0	275	c.259G>A	c.(259-261)Gcc>Acc	p.A87T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	Homo sapiens POM121 membrane glycoprotein-like 12 (POM121L12), mRNA.	87										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCAGGACCCCGCCAAGCCGCA	0.701000													11	26					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49485161	49485161	+	Silent	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:49485161C>T	uc001rtf.3	-	1	622	c.315G>A	c.(313-315)gaG>gaA	p.E105E		NM_021044	NP_066382	O43323	DHH_HUMAN	Homo sapiens desert hedgehog (DHH), mRNA.	105					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						CGTTCACCCGCTCCTTACAAC	0.587000													4	26					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45317538	45317538	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:45317538G>A	uc002ozu.3	+	6	958	c.914G>A	c.(913-915)cGc>cAc	p.R305H	BCAM_uc002ozt.1_Missense_Mutation_p.R305H	NM_005581	NP_005572	P50895	BCAM_HUMAN	Homo sapiens basal cell adhesion molecule (Lutheran blood group) (BCAM), transcript variant 1, mRNA.	305	Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				ACGCTTTTCCGCCTTCAGGTG	0.652000													7	87					0	0	1	0	0
CCDC112	153733	broad.mit.edu	37	5	114611297	114611297	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr5:114611297T>A	uc003kqz.2	-	5	752	c.534A>T	c.(532-534)gaA>gaT	p.E178D	CCDC112_uc003kqy.2_Missense_Mutation_p.E95D|CCDC112_uc003kra.2_Missense_Mutation_p.E178D	NM_001040440	NP_689762	Q8NEF3	CC112_HUMAN	Homo sapiens coiled-coil domain containing 112 (CCDC112), transcript variant 1, mRNA.	95										endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|skin(1)	20		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		TAATTAGCTCTTCATATCTAA	0.289000													5	40					0	0	1	0	0
BAGE1	0	broad.mit.edu	37	GL000237.1	2582	2582	+	RNA	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chrGL000237.1:2582C>T	uc011mgu.1	-	0		c.105G>A								Homo sapiens B melanoma antigen variant f (BAGE1) mRNA, complete cds, alternatively spliced.																		cagagcgagacgagccacggt	0.607000													3	11					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160047852	160047852	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr5:160047852T>C	uc003lym.1	-	14	2765	c.1918A>G	c.(1918-1920)Act>Gct	p.T640A	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.3_Missense_Mutation_p.T198A	NM_025153	NP_079429	O94823	AT10B_HUMAN	Homo sapiens ATPase, class V, type 10B (ATP10B), mRNA.	640					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGGGTGCAGTGGATGAGAAT	0.552000													10	154					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87225083	87225083	+	Splice_Site	SNP	A	A	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr7:87225083A>T	uc003uiz.2	-	4	610	c.117_splice	c.e4+1	p.M39_splice	ABCB1_uc011khc.2_Splice_Site_p.M39_splice	NM_000927	NP_000918	P08183	MDR1_HUMAN	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), mRNA.	39					G2/M transition of mitotic cell cycle|stem cell proliferation	Golgi membrane|apical plasma membrane|cell surface|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AAAACTCACCATTGAAAATAC	0.274000													4	32					0	0	1	0	0
LZTS2	84445	broad.mit.edu	37	10	102762582	102762582	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr10:102762582G>A	uc001ksj.3	+	1	457	c.287G>A	c.(286-288)cGg>cAg	p.R96Q	LZTS2_uc010qpw.2_Missense_Mutation_p.R96Q|LZTS2_uc001ksk.3_Missense_Mutation_p.R96Q|LZTS2_uc001ksl.3_Missense_Mutation_p.R96Q|LZTS2_uc001ksm.3_Non-coding_Transcript	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	Homo sapiens leucine zipper, putative tumor suppressor 2 (LZTS2), mRNA.	96	Required for centrosomal localization (By similarity).				Wnt receptor signaling pathway|cell division|mitosis	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GAGGACTTCCGGACAGAGTCA	0.627000													13	47					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018760	62018760	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:62018760C>T	uc002jds.1	-	23	4959	c.4882G>A	c.(4882-4884)Gac>Aac	p.D1628N		NM_000334	NP_000325	P35499	SCN4A_HUMAN	Homo sapiens sodium channel, voltage-gated, type IV, alpha subunit (SCN4A), mRNA.	1628					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCGTCGGGGTCGAACTTCTCC	0.562000													10	61					0	0	1	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163187	163187	+	RNA	SNP	T	T	C	rs143599805	by1000genomes	TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr8:163187T>C	uc010lra.3	-	3		c.946A>G			RPL23AP53_uc003woq.4_Non-coding_Transcript|RPL23AP53_uc010lrb.3_Non-coding_Transcript					Homo sapiens ribosomal protein L23a pseudogene 53 (RPL23AP53), non-coding RNA.																		TGAAAAACATTATTCTTTTAT	0.294000													3	28					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38924806	38924806	+	Missense_Mutation	SNP	C	C	T	rs147061364	byFrequency	TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr3:38924806C>T	uc021wvy.1	-	17	3336	c.3137G>A	c.(3136-3138)cGg>cAg	p.R1046Q	SCN11A_uc010hhn.1_Missense_Mutation_p.R124Q	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	Homo sapiens sodium channel, voltage-gated, type XI, alpha subunit (SCN11A), mRNA.	1046					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCAGGTTTTCCGCAGGTTCCA	0.453000													6	69					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40475084	40475084	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:40475084C>G	uc002hzl.1	-	19	2066	c.1826G>C	c.(1825-1827)aGa>aCa	p.R609T	STAT3_uc002hzk.1_Missense_Mutation_p.R609T|STAT3_uc002hzm.1_Missense_Mutation_p.R609T|STAT3_uc010wgh.1_Missense_Mutation_p.R511T|STAT3_uc002hzn.1_Missense_Mutation_p.R609T	NM_139276	NP_644805	P40763	STAT3_HUMAN	Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA.	609	SH2.				JAK-STAT cascade involved in growth hormone signaling pathway|cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TTCACTGAATCTTAGCAGGAA	0.562000									Hyperimmunoglobulin E Recurrent Infection Syndrome		OREG0024421	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	124					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118949955	118949955	+	Silent	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:118949955C>A	uc010ryx.2	+	14	2419	c.2377C>A	c.(2377-2379)Cgg>Agg	p.R793R	VPS11_uc010ryy.2_Silent_p.R641R	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	Homo sapiens vacuolar protein sorting 11 homolog (S. cerevisiae) (VPS11), mRNA.	795					protein transport	HOPS complex|endocytic vesicle|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GCGGGTGCGGCGGTACCGAGA	0.582000													3	13					0	0	1	0	0
HOXC8	3224	broad.mit.edu	37	12	54403269	54403269	+	Silent	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:54403269C>A	uc001ser.3	+	0	380	c.201C>A	c.(199-201)atC>atA	p.I67I		NM_022658	NP_073149	P31273	HXC8_HUMAN	Homo sapiens homeobox C8 (HOXC8), mRNA.	67						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						CCTCCGGCATCTCCAACTCAG	0.637000													15	260					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296403	145296403	+	Silent	SNP	C	C	T	rs4996269	by1000genomes	TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr1:145296403C>T	uc021oul.1	+	2	360	c.325C>T	c.(325-327)Cta>Tta	p.L109L	NBPF10_uc021ots.1_Intron|NBPF10_uc010oye.2_Intron|NBPF10_uc021ouk.1_Silent_p.L109L|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	109										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGACCCAGCTAAGGGAGAA	0.517000													7	250					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130830316	130830316	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:130830316G>A	uc001uik.3	+	3	480	c.209G>A	c.(208-210)gGa>gAa	p.G70E	PIWIL1_uc001uij.2_Missense_Mutation_p.G70E	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	Homo sapiens piwi-like 1 (Drosophila) (PIWIL1), transcript variant 1, mRNA.	70					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	P granule|chromatoid body	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATATCTGCTGGATTTCAGGAG	0.378000													14	57					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938178	15938178	+	Frame_Shift_Del	DEL	T	T	-	rs144178676		TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr4:15938178delT	uc003gom.3	-	2	373	c.78delA	c.(76-78)aaafs	p.K26fs	FGFBP1_uc021xml.1_Frame_Shift_Del_p.K26fs	NM_005130	NP_005121	Q14512	FGFP1_HUMAN	Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.	26					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						CATTCTTCACTTTTTTTTTCC	0.527													7	107	---	---	---	---					
REV3L	5980	broad.mit.edu	37	6	111654323	111654324	+	Splice_Site	INS	-	-	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr6:111654323_111654324insA	uc003puy.4	-	23	8266	c.7925_splice	c.e23+1	p.K2642_splice	REV3L_uc003pux.4_Splice_Site_p.K2564_splice|REV3L_uc003puz.4_Splice_Site_p.K2564_splice|REV3L_uc003pva.1_Splice_Site	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	Homo sapiens REV3-like, catalytic subunit of DNA polymerase zeta (yeast) (REV3L), mRNA.	2642					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAAAAAACCTTACTTTCCCAAG	0.371								DNA polymerases (catalytic subunits)					9	45	---	---	---	---					
CSNK1A1L	122011	broad.mit.edu	37	13	37678967	37678967	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr13:37678967delG	uc001uwm.1	-	0	835	c.427delC	c.(427-429)ctgfs	p.L143fs		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	Homo sapiens casein kinase 1, alpha 1-like (CSNK1A1L), mRNA.	143	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GTACCCATCAGGAAGTTATCT	0.408													9	120	---	---	---	---					
MIS18BP1	55320	broad.mit.edu	37	14	45711597	45711601	+	Frame_Shift_Del	DEL	AGTGG	AGTGG	-			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr14:45711597_45711601delAGTGG	uc001wwf.3	-	3	1238_1242	c.779_783delCCACT	c.(778-783)accactfs	p.T260fs	MIS18BP1_uc010anh.2_Non-coding_Transcript	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	Homo sapiens MIS18 binding protein 1 (MIS18BP1), mRNA.	260					CenH3-containing nucleosome assembly at centromere|cell division|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						TTTTGGATTTAGTGGTTGCAACTAT	0.356													11	89	---	---	---	---					
THOC1	9984	broad.mit.edu	37	18	214519	214520	+	Splice_Site	INS	-	-	TTG	rs142588910		TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr18:214519_214520insTTG	uc002kkj.4	-	21	2120	c.2080_splice	c.e21+1		THOC1_uc002kkh.4_Splice_Site	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	Homo sapiens THO complex 1 (THOC1), mRNA.						RNA splicing|apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|signal transduction|transcription, DNA-dependent	THO complex part of transcription export complex|cytoplasm|nuclear matrix|nuclear speck	DNA binding|RNA binding|protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	20		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CTGTACAACAATTGTTATAAAA	0.351													3	3	---	---	---	---					
