Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD36BP2	645784	broad.mit.edu	37	2	89086005	89086005	+	RNA	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:89086005C>T	uc010fhg.3	+	7		c.796C>T			ANKRD36BP2_uc010fhh.3_Non-coding_Transcript					Homo sapiens ankyrin repeat domain 36B pseudogene 2 (ANKRD36BP2), non-coding RNA.																		CAGAAACAATCGGCCTGGAAG	0.303000													3	6					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241725859	241725859	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:241725859G>A	uc010fzk.3	-	5	748	c.501C>T	c.(499-501)cgC>cgT	p.R167R	KIF1A_uc002vzy.3_Silent_p.R167R|KIF1A_uc002vzz.2_Silent_p.R167R	NM_001244008	NP_001230937	Q12756	KIF1A_HUMAN	Homo sapiens kinesin family member 1A (KIF1A), transcript variant 1, mRNA.	167	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GCTCCCTCACGCGAAGGTTGC	0.602000													62	94					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:29628245G>A	uc010ztl.1	+	2	189	c.157G>A	c.(157-159)Gcc>Acc	p.A53T	FRG1B_uc002wvm.1_Non-coding_Transcript|FRG1B_uc010ztj.1_Non-coding_Transcript|FRG1B_uc010gdr.1_Non-coding_Transcript|FRG1B_uc010ztk.1_Missense_Mutation_p.A5T					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.									p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													4	188					0	0	1	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85055854	85055854	+	RNA	SNP	T	T	A	rs4039972		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:85055854T>A	uc002bkm.2	-	5		c.706A>T								Homo sapiens golgin A6 family-like 5 (pseudogene) (GOLGA6L5), non-coding RNA.																		CTGTTCACGTTGCCTCTCCTC	0.542000													3	20					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:107049631C>T	uc010ywi.1	-	15	2373	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	Homo sapiens RANBP2-like and GRIP domain containing 3 (RGPD3), mRNA.	772					intracellular transport		binding	p.A772A(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													5	311					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55524135	55524135	+	Missense_Mutation	SNP	G	G	A	rs77545847	byFrequency	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:55524135G>A	uc010spe.2	+	0	583	c.583G>A	c.(583-585)Gct>Act	p.A195T		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	Homo sapiens olfactory receptor, family 9, subfamily K, member 2 (OR9K2), mRNA.	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C194C(1)		NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						ATCTTTTTGCGCTTCTCGGGC	0.418000													24	70					0	0	1	0	0
AGAP9	642517	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr10:47207813T>C	uc009xnf.2	-	4	508	c.396_splice	c.e4+1	p.H132_splice	AGAP9_uc001jei.3_Splice_Site	NM_001190810	NP_001177739	D3YTF3	D3YTF3_HUMAN	Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 (AGAP9), mRNA.	132					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.H228R(20)									TTTACTTACATGGTTTGTACA	0.294000													3	23					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16593777	16593777	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:16593777C>T	uc002gqk.1	+	0	139	c.63C>T	c.(61-63)taC>taT	p.Y21Y		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	Homo sapiens coiled-coil domain containing 144A (CCDC144A), mRNA.	21																	CGGCAGTCTACGCCACGAGGA	0.667000													18	27					0	0	1	0	0
ZSCAN30	100101467	broad.mit.edu	37	18	32843993	32843993	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr18:32843993C>T	uc002kyl.3	-	2	780	c.324G>A	c.(322-324)ctG>ctA	p.L108L	ZNF397_uc010dmr.3_Intron|ZSCAN30_uc002kym.3_Silent_p.L108L|ZSCAN30_uc002kyn.1_Silent_p.L108L	NM_001166012	NP_001159484	Q86W11	ZSC30_HUMAN	Homo sapiens zinc finger and SCAN domain containing 30 (ZSCAN30), mRNA.	108	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|lung(3)|urinary_tract(1)	9						GATGCTCTCGCAGCCAAGCTT	0.547000													5	96					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50344881	50344881	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:50344881G>A	uc001rvn.3	+	0	358	c.268G>A	c.(268-270)Gtg>Atg	p.V90M		NM_000486	NP_000477	P41181	AQP2_HUMAN	Homo sapiens aquaporin 2 (collecting duct) (AQP2), mRNA.	90					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						CGCCTTCTACGTGGCTGCCCA	0.662000													13	37					0	0	1	0	0
OR4N3P	390539	broad.mit.edu	37	15	22413985	22413985	+	Missense_Mutation	SNP	A	A	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:22413985A>G	uc001yuf.3	+	0	524	c.284A>G	c.(283-285)gAc>gGc	p.D95G	abParts_uc001yuj.2_Intron					Homo sapiens olfactory receptor, family 4, subfamily N, member 3 pseudogene (OR4N3P), non-coding RNA.																		AACCAGCTGGACAACTTCTTC	0.507000													33	308					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3017847	3017847	+	Missense_Mutation	SNP	T	T	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:3017847T>A	uc010zqd.2	+	21	2596	c.2279T>A	c.(2278-2280)cTg>cAg	p.L760Q	PTPRA_uc002whj.3_Missense_Mutation_p.L749Q|PTPRA_uc002whk.3_Missense_Mutation_p.L740Q|PTPRA_uc002whl.3_Missense_Mutation_p.L740Q|PTPRA_uc002whm.3_Missense_Mutation_p.L516Q|PTPRA_uc002whn.3_Missense_Mutation_p.L740Q|PTPRA_uc002who.3_Missense_Mutation_p.L412Q	NM_002836	NP_002827	P18433	PTPRA_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript variant 1, mRNA.	749	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AGCACCGTCCTGGAGCGTGTG	0.592000													38	76					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57458438	57458438	+	Missense_Mutation	SNP	G	G	A	rs138462668	byFrequency	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrX:57458438G>A	uc004dvc.3	+	7	1233	c.1084G>A	c.(1084-1086)Gca>Aca	p.A362T		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	Homo sapiens fatty acid amide hydrolase 2 (FAAH2), mRNA.	362						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GTTGTGGATCGCAATGATGTC	0.348000										HNSCC(52;0.14)			31	4					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19041626	19041626	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:19041626G>A	uc002dfp.2	+	5	922	c.792G>A	c.(790-792)ctG>ctA	p.L264L	TMC7_uc010vao.1_Silent_p.L264L|TMC7_uc002dfq.3_Silent_p.L264L|TMC7_uc010vap.2_Silent_p.L154L	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	Homo sapiens transmembrane channel-like 7 (TMC7), transcript variant 1, mRNA.	264						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CCTATGATCTGCCCCTGGCGT	0.468000													36	63					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3691150	3691150	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:3691150C>T	uc001lyf.3	-	1	155	c.83G>A	c.(82-84)cGg>cAg	p.R28Q	CHRNA10_uc010qxt.2_5'UTR|CHRNA10_uc010qxu.2_Intron	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	Homo sapiens cholinergic receptor, nicotinic, alpha 10 (CHRNA10), mRNA.	28					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GAGAGCCAGCCGGCCCTCAGC	0.612000													31	62					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76435207	76435207	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:76435207C>T	uc010dhp.2	-	72	11895	c.11770G>A	c.(11770-11772)Gtg>Atg	p.V3924M	DNAH17_uc002jvq.3_Missense_Mutation_p.V209M|DNAH17_uc002jvs.3_Non-coding_Transcript	NM_173628	NP_775899			Homo sapiens dynein, axonemal, heavy chain 17 (DNAH17), mRNA.									p.G3924A(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGCAGCCACGTCCAGGGCG	0.562000													4	37					0	0	1	0	0
RPA4	29935	broad.mit.edu	37	X	96140039	96140039	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrX:96140039G>A	uc004efv.4	+	0	1133	c.730G>A	c.(730-732)Gtt>Att	p.V244I	DIAPH2_uc004eft.4_Intron|DIAPH2_uc004efu.4_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	Homo sapiens replication protein A4, 30kDa (RPA4), mRNA.	244					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						TTATCTGACCGTTGAGGGCCA	0.507000								Other identified genes with known or suspected DNA repair function					3	39					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76117241	76117241	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:76117241G>A	uc002juj.1	-	10	1514	c.1388C>T	c.(1387-1389)cCa>cTa	p.P463L	TMC6_uc002jui.1_Missense_Mutation_p.P102L|TMC6_uc010dhf.1_Missense_Mutation_p.P296L|TMC6_uc002juk.2_Missense_Mutation_p.P463L|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Missense_Mutation_p.P463L|TMC6_uc002jum.4_Missense_Mutation_p.P254L|TMC6_uc002jun.4_Missense_Mutation_p.P463L|TMC6_uc002juo.2_Missense_Mutation_p.P236L	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	Homo sapiens transmembrane channel-like 6 (TMC6), transcript variant 2, mRNA.	463						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCAGCCTCTGGACTCTGCAG	0.697000													6	15					0	0	1	0	0
LOC390660	390660	broad.mit.edu	37	15	82620400	82620400	+	RNA	SNP	T	T	C			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:82620400T>C	uc021ssl.1	+	18		c.3880T>C			LOC390660_uc010bls.1_Non-coding_Transcript					Homo sapiens FLJ00317 protein (LOC390660), non-coding RNA.																		GACCCAAGGGTCAGCCTGAGT	0.672000													4	29					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117104291	117104291	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr9:117104291G>A	uc004biq.3	-	18	4007	c.3872C>T	c.(3871-3873)tCt>tTt	p.S1291F	AKNA_uc004bin.3_Missense_Mutation_p.S538F|AKNA_uc004bio.3_Missense_Mutation_p.S751F|AKNA_uc004bip.3_Missense_Mutation_p.S1210F|AKNA_uc004bir.3_Missense_Mutation_p.S1291F|AKNA_uc004bis.3_Missense_Mutation_p.S1291F|AKNA_uc010mve.2_Missense_Mutation_p.S1172F	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	Homo sapiens AT-hook transcription factor (AKNA), mRNA.	1291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GTCCCTACCAGAGGTGGCTGA	0.567000													33	71					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6554692	6554692	+	Missense_Mutation	SNP	A	A	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:6554692A>G	uc001qod.3	+	1	450	c.239A>G	c.(238-240)cAc>cGc	p.H80R	CD27-AS1_uc001qob.2_Intron|CD27-AS1_uc009zel.1_Intron	NM_001242	NP_001233	P26842	CD27_HUMAN	Homo sapiens CD27 molecule (CD27), mRNA.	80					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						ACCCGGCCCCACTGTGAGAGC	0.587000													21	45					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73622050	73622050	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:73622050G>A	uc002avp.3	-	3	2448	c.1454C>T	c.(1453-1455)gCg>gTg	p.A485V		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA.	485					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GCCCACGGGCGCCTGCCGCCC	0.622000													39	62					0	0	1	0	0
BC063132	0	broad.mit.edu	37	GL000241.1	36849	36849	+	RNA	SNP	C	C	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrGL000241.1:36849C>G	uc011mgv.2	-	0		c.27G>C								Homo sapiens cDNA clone IMAGE:4673444, containing frame-shift errors.																		CGGAGCAGCACCAGGGCGGGG	0.577000													3	20					0	0	1	0	0
FLJ43315	644316	broad.mit.edu	37	GL000211.1	91951	91951	+	RNA	SNP	C	C	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrGL000211.1:91951C>G	uc003bnz.1	+	6		c.1307C>G			FLJ43315_uc003boa.3_Intron					Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding RNA.																		GTAAATTTATCTATAGATTTC	0.318000													3	9					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50900484	50900484	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr22:50900484C>T	uc003blh.3	-	19	2656	c.2461G>A	c.(2461-2463)Gac>Aac	p.D821N	SBF1_uc011arx.2_Missense_Mutation_p.D485N|SBF1_uc003bli.2_Missense_Mutation_p.D822N	NM_002972	NP_002963	O95248	MTMR5_HUMAN	Homo sapiens SET binding factor 1 (SBF1), mRNA.	821					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CCAGCTACGTCGCAGGTCTCT	0.617000													63	158					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796912	127796912	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr6:127796912G>A	uc003qbd.3	-	5	3124	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	KIAA0408_uc003qbc.3_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	Homo sapiens chromosome 6 open reading frame 174 (C6orf174), mRNA.	753						integral to membrane											CGTCGCTCTCGGCGTCGCTGT	0.697000													7	132					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52383437	52383437	+	Splice_Site	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr3:52383437G>A	uc011bef.2	+	14	2787	c.2526_splice	c.e14+1	p.S842_splice	DNAH1_uc003ddt.1_Splice_Site_p.S842_splice	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA.	842	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGTGGATAGCGTAAGTGCCCA	0.582000													3	35					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54410070	54410070	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr5:54410070C>T	uc003jpo.2	-	11	1713	c.1536G>A	c.(1534-1536)acG>acA	p.T512T	CDC20B_uc003jpn.2_Silent_p.T508T|CDC20B_uc010ivu.2_Silent_p.T470T	NM_001170402	NP_001163873	Q86Y33	CD20B_HUMAN	Homo sapiens cell division cycle 20 homolog B (S. cerevisiae) (CDC20B), transcript variant 3, mRNA.	512										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			atacagaggccgtcccatcag	0.527000													26	57					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156786061	156786061	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr5:156786061G>A	uc021ygm.1	+	23	2857	c.2719G>A	c.(2719-2721)Gtg>Atg	p.V907M	CYFIP2_uc011ddn.2_Missense_Mutation_p.V882M|CYFIP2_uc011ddo.2_Missense_Mutation_p.V712M|CYFIP2_uc021ygn.1_Missense_Mutation_p.V907M|CYFIP2_uc021ygo.1_Missense_Mutation_p.V907M|CYFIP2_uc003lwt.3_Missense_Mutation_p.V811M|CYFIP2_uc011ddp.2_Missense_Mutation_p.V642M	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	Homo sapiens cytoplasmic FMR1 interacting protein 2 (CYFIP2), transcript variant 1, mRNA.	933					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGGAATTTCGTGGGGCCACC	0.488000													6	280					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238562	104238562	+	Missense_Mutation	SNP	C	C	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr9:104238562C>A	uc004bbm.3	-	1	1135	c.813G>T	c.(811-813)ttG>ttT	p.L271F	AK094413_uc004bbl.1_5'Flank|TMEM246_uc022blf.1_Missense_Mutation_p.L271F	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	Homo sapiens chromosome 9 open reading frame 125 (C9orf125), mRNA.	271						integral to membrane											AGGGCCCCAGCAACATGCCTA	0.537000													70	129					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89013441	89013441	+	Missense_Mutation	SNP	A	A	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr4:89013441A>G	uc003hrg.3	-	15	2406	c.1913T>C	c.(1912-1914)gTt>gCt	p.V638A	ABCG2_uc003hrh.3_3'UTR|ABCG2_uc003hrf.3_Missense_Mutation_p.V506A	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), mRNA.	638	ABC transmembrane type-2.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGGAAAATAACAATCATACA	0.363000													22	45					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	A	G	rs2257765		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr10:38654432A>G	uc010qex.1	+	4	599	c.524A>G	c.(523-525)aAt>aGt	p.N175S	HSD17B7P2_uc001izq.3_Non-coding_Transcript|HSD17B7P2_uc001izo.1_Non-coding_Transcript|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					Homo sapiens hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 (HSD17B7P2), non-coding RNA.																		TCATCTCGCAATGCAAGGAAA	0.453000													5	60					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895797	24895797	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr13:24895797G>A	uc001upj.3	+	3	954	c.893G>A	c.(892-894)gGg>gAg	p.G298E	SPATA13_uc001upe.3_Non-coding_Transcript	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	Homo sapiens C1q and tumor necrosis factor related protein 9 (C1QTNF9), mRNA.	298	C1q.					collagen	hormone activity	p.G298R(1)		endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CTGAAGCTCGGGGATGAGGTG	0.507000													4	121					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95795914	95795914	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:95795914G>T	uc003ygx.2	+	16	1856	c.1732G>T	c.(1732-1734)Gca>Tca	p.A578S		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	Homo sapiens dpy-19-like 4 (C. elegans) (DPY19L4), mRNA.	578						integral to membrane		p.A578T(2)		breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					AGCTCCAGTTGCAGCTGTGTT	0.403000													15	24					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10464989	10464989	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:10464989G>T	uc003wtc.3	-	3	6848	c.6619C>A	c.(6619-6621)Cca>Aca	p.P2207T		NM_178857	NP_849188	A6NKC6	A6NKC6_HUMAN	Homo sapiens retinitis pigmentosa 1-like 1 (RP1L1), mRNA.	2207					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCTAACTCTGGTTGGGCCTCC	0.632000													26	429					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75929559	75929559	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:75929559C>T	uc003yan.3	+	9	1511	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	CRISPLD1_uc011lfk.2_Missense_Mutation_p.S146F|CRISPLD1_uc011lfl.2_Missense_Mutation_p.S146F	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	Homo sapiens cysteine-rich secretory protein LCCL domain containing 1 (CRISPLD1), mRNA.	334	LCCL 1.					extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TCCAAGCAATCCAGCATCTGT	0.338000													5	84					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718522	103718522	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr13:103718522G>T	uc001vpy.4	-	0	675	c.78C>A	c.(76-78)ttC>ttA	p.F26L		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (SLC10A2), mRNA.	26					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGATGTTATTGAAATTGCTCT	0.478000													7	133					0	0	1	0	0
ZFYVE27	118813	broad.mit.edu	37	10	99502873	99502873	+	Missense_Mutation	SNP	T	T	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr10:99502873T>G	uc001kol.2	+	2	426	c.220T>G	c.(220-222)Ttg>Gtg	p.L74V	ZFYVE27_uc001kok.2_Non-coding_Transcript|ZFYVE27_uc010qpc.2_Non-coding_Transcript|ZFYVE27_uc001kom.2_Missense_Mutation_p.L74V|ZFYVE27_uc010qpb.2_Intron|ZFYVE27_uc010qpd.2_Intron|ZFYVE27_uc001koq.3_Intron|ZFYVE27_uc010qpa.2_Intron|ZFYVE27_uc021pwq.1_Missense_Mutation_p.L74V	NM_144588	NP_653189	Q5T4F4	ZFY27_HUMAN	Homo sapiens zinc finger, FYVE domain containing 27 (ZFYVE27), transcript variant 2, mRNA.	74					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		TTTGTGTTCCTTGCTGACCTG	0.547000													41	87					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3797159	3797159	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:3797159G>T	uc001lyh.3	-	4	869	c.448C>A	c.(448-450)Cca>Aca	p.P150T	NUP98_uc001lyi.3_Missense_Mutation_p.P150T|NUP98_uc001lyj.2_Missense_Mutation_p.P150T|NUP98_uc001lyk.2_Missense_Mutation_p.P150T|NUP98_uc010qxv.2_Missense_Mutation_p.P113T	NM_016320	NP_057404	P52948	NUP98_HUMAN	Homo sapiens nucleoporin 98kDa (NUP98), transcript variant 1, mRNA.	150	Gly/Thr-rich.				DNA replication|carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|mitotic prometaphase|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|cytosol|nuclear membrane|nucleoplasm	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AAACTACTTGGCCCAAAGAGG	0.398000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								4	131					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398710	89398710	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:89398710C>T	uc010upo.1	+	11	3268	c.2894C>T	c.(2893-2895)aCc>aTc	p.T965I	ACAN_uc010upp.1_Missense_Mutation_p.T965I|ACAN_uc002bna.2_Non-coding_Transcript	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	Homo sapiens aggrecan (ACAN), transcript variant 2, mRNA.	965					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GTTCTAGAGACCTCTGCCTCT	0.562000													5	226					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121746844	121746844	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:121746844C>T	uc010flp.3	+	12	3384	c.3354C>T	c.(3352-3354)ggC>ggT	p.G1118G	GLI2_uc002tmq.1_Silent_p.G790G|GLI2_uc002tmr.1_Silent_p.G773G|GLI2_uc002tmt.4_Silent_p.G790G|GLI2_uc002tmu.4_Silent_p.G773G	NM_005270	NP_005261	P10070	GLI2_HUMAN	Homo sapiens GLI family zinc finger 2 (GLI2), mRNA.	1118					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCAACGTGGGCCCCTCCGCCC	0.622000													33	62					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605984	47605984	+	Missense_Mutation	SNP	C	C	T	rs9600		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:47605984C>T	uc001nga.2	+	6	828	c.746C>T	c.(745-747)cCg>cTg	p.P249L	NDUFS3_uc001nft.3_Missense_Mutation_p.P228L|FAM180B_uc001ngb.2_5'Flank	NM_004551	NP_004542	O75489	NDUS3_HUMAN	Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (NDUFS3), nuclear gene encoding mitochondrial protein, mRNA.	249			P -> Q (in dbSNP:rs9600).		induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|electron carrier activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	CGCCAACCCCCGGAGAGTCTC	0.567000													61	190					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:33345744C>T	uc002xav.3	-	7	3378	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_uc002xaw.3_Silent_p.Q269Q|NCOA6_uc021wcd.1_Silent_p.Q269Q|NCOA6_uc021wce.1_Silent_p.Q269Q|NCOA6_uc021wcf.1_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	Homo sapiens nuclear receptor coactivator 6 (NCOA6), transcript variant 1, mRNA.	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				DNA recombination|DNA repair|DNA replication|brain development|cellular lipid metabolic process|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(29)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	58					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328050	126328050	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr4:126328050G>A	uc003ifj.4	+	2	5323	c.5323G>A	c.(5323-5325)Gtc>Atc	p.V1775I	FAT4_uc011cgp.2_Missense_Mutation_p.V73I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	1775	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAATGCTCTCGTCACATACAC	0.433000													17	127					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58545390	58545390	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:58545390G>A	uc002enm.3	+	15	1427	c.1086G>A	c.(1084-1086)tcG>tcA	p.S362S	NDRG4_uc002enk.3_Silent_p.S342S|NDRG4_uc010vif.2_Silent_p.S342S|NDRG4_uc002eno.3_Silent_p.S323S|NDRG4_uc010cdk.3_Silent_p.S328S|NDRG4_uc010vig.2_Silent_p.S340S|NDRG4_uc010vih.2_Silent_p.S255S|NDRG4_uc010vii.2_Silent_p.S328S|NDRG4_uc002enp.3_Silent_p.S310S|NDRG4_uc002enq.1_Intron	NM_001130487	NP_075061	Q9ULP0	NDRG4_HUMAN	Homo sapiens NDRG family member 4 (NDRG4), transcript variant 2, mRNA.	323					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						GTGCCAGCTCGGTGGATGGCA	0.657000													4	136					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182468750	182468751	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:182468750_182468751delAT	uc002unx.3	-	1	395_396	c.294_295delAT	c.(292-297)atattcfs	p.I98fs	CERKL_uc010frk.3_Non-coding_Transcript|CERKL_uc002uny.3_Frame_Shift_Del_p.I98fs|CERKL_uc010zfm.2_Frame_Shift_Del_p.I98fs|CERKL_uc002unz.3_5'UTR|CERKL_uc002uoa.3_Frame_Shift_Del_p.I98fs|CERKL_uc002uob.3_5'UTR|CERKL_uc002uoc.3_Frame_Shift_Del_p.I98fs|CERKL_uc021vth.1_5'UTR|CERKL_uc021vti.1_5'UTR|CERKL_uc021vtj.1_5'UTR|CERKL_uc021vtk.1_5'UTR|CERKL_uc021vtl.1_5'UTR|CERKL_uc021vtm.1_5'UTR|CERKL_uc002uod.2_5'UTR|CERKL_uc002uoe.3_Frame_Shift_Del_p.I98fs	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	Homo sapiens ceramide kinase-like (CERKL), transcript variant 2, mRNA.	98					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	Golgi apparatus|endoplasmic reticulum|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTCACAGAGAATATGTCTTTGA	0.307													19	34	---	---	---	---					
ABCA12	26154	broad.mit.edu	37	2	215843155	215843156	+	Frame_Shift_Ins	INS	-	-	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:215843155_215843156insT	uc002vew.3	-	32	5232_5233	c.5012_5013insA	c.(5011-5013)aatfs	p.N1671fs	ABCA12_uc002vev.3_Frame_Shift_Ins_p.N1353fs|ABCA12_uc010zjn.2_Frame_Shift_Ins_p.N598fs	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 12 (ABCA12), transcript variant 1, mRNA.	1671					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATAGCACTATTTTTTTGTGA	0.376													7	23	---	---	---	---					
SAMD3	154075	broad.mit.edu	37	6	130535491	130535491	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr6:130535491delG	uc003qbw.3	-	3	588	c.260delC	c.(259-261)gcafs	p.A87fs	SAMD3_uc003qbx.3_Frame_Shift_Del_p.A87fs|SAMD3_uc010kfg.1_Frame_Shift_Del_p.A87fs|SAMD3_uc003qby.3_Frame_Shift_Del_p.A87fs|SAMD3_uc003qbz.1_Frame_Shift_Del_p.A46fs	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	Homo sapiens sterile alpha motif domain containing 3 (SAMD3), transcript variant 1, mRNA.	87								p.A87A(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTCTCGAGCTGCTTCTGTTTG	0.428													12	197	---	---	---	---					
FJX1	24147	broad.mit.edu	37	11	35640220	35640220	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:35640220delG	uc001mwh.3	+	0	486	c.36delG	c.(34-36)gcgfs	p.A12fs		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	Homo sapiens four jointed box 1 (Drosophila) (FJX1), mRNA.	12						extracellular space				lung(1)|urinary_tract(1)	2	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				CCGCCACCGCGGGGCTCTGGC	0.801													2	4	---	---	---	---					
MLH3	27030	broad.mit.edu	37	14	75514337	75514338	+	Frame_Shift_Ins	INS	-	-	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr14:75514337_75514338insT	uc001xrd.1	-	1	2237_2238	c.2021_2022insA	c.(2020-2022)aatfs	p.N674fs	MLH3_uc001xre.1_Frame_Shift_Ins_p.N674fs|MLH3_uc010tuy.1_Non-coding_Transcript	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	Homo sapiens mutL homolog 3 (E. coli) (MLH3), transcript variant 1, mRNA.	674					mismatch repair|reciprocal meiotic recombination	MutLbeta complex|chiasma|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TCGTTCTGCAATTTTTTTTGTT	0.347								Mismatch excision repair (MMR)					26	48	---	---	---	---					
CACNA1H	8912	broad.mit.edu	37	16	1259227	1259227	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:1259227delG	uc002cks.3	+	16	3807	c.3559delG	c.(3559-3561)gggfs	p.G1187fs	CACNA1H_uc002ckt.3_Frame_Shift_Del_p.G1187fs|CACNA1H_uc002cku.3_5'Flank|CACNA1H_uc010brj.3_5'Flank|CACNA1H_uc002ckv.3_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H), transcript variant 1, mRNA.	1187					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCCGCGCCCGGGCCCCGTGC	0.761													2	4	---	---	---	---					
