Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LIN28B	389421	broad.mit.edu	37	6	105406094	105406094	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:105406094G>T	uc003pqv.1	+	1	334	c.131G>T	c.(130-132)gGa>gTa	p.G44V	LIN28B_uc010kda.1_Missense_Mutation_p.G4V	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	Homo sapiens lin-28 homolog B (C. elegans) (LIN28B), mRNA.	44	CSD.				RNA 3'-end processing|miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|RNA binding|protein binding|zinc ion binding			large_intestine(1)|lung(10)|ovary(1)	12		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				ATGGGATTTGGATTCATCTCC	0.517000													19	114					0	0	1	0	0
AK022914	0	broad.mit.edu	37	22	16151010	16151010	+	RNA	SNP	T	T	C	rs143820047	by1000genomes	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr22:16151010T>C	uc002zks.4	-	7		c.1647A>G								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		AGTTGTTCTCTGGAATCAATC	0.393000													4	19					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54617801	54617801	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr7:54617801G>A	uc022adk.1	+	3	977	c.572G>A	c.(571-573)cGa>cAa	p.R191Q	VSTM2A_uc010kzf.3_Missense_Mutation_p.R191Q	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	Homo sapiens V-set and transmembrane domain containing 2A (VSTM2A), mRNA.	191						extracellular region		p.R191Q(2)|p.R190Q(2)		endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GCCAACCAACGAACGCACTCC	0.547000													7	13					0	0	1	0	0
FUT1	2523	broad.mit.edu	37	19	49253917	49253917	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:49253917C>T	uc002pkk.3	-	3	1597	c.622G>A	c.(622-624)Ggg>Agg	p.G208R	FUT1_uc021uwy.1_Missense_Mutation_p.G208R	NM_000148	NP_000139	P19526	FUT1_HUMAN	Homo sapiens fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) (FUT1), mRNA.	208					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(3)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		GGGCGGTCCCCTGTGCGGCCC	0.667000													11	257					0	0	1	0	0
C9orf156	51531	broad.mit.edu	37	9	100675695	100675695	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr9:100675695C>T	uc004axv.1	-	2	474	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	C9orf156_uc004axw.1_5'UTR|C9orf156_uc010msq.1_5'UTR|C9orf156_uc022bku.1_Missense_Mutation_p.E133K	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Homo sapiens chromosome 9 open reading frame 156 (C9orf156), mRNA.	133					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				TCTACCTTTTCCAGCTTGGCC	0.433000													27	62					0	0	1	0	0
VGLL2	245806	broad.mit.edu	37	6	117593620	117593620	+	Missense_Mutation	SNP	G	G	A	rs143287461	by1000genomes	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:117593620G>A	uc003pxn.3	+	3	1123	c.917G>A	c.(916-918)cGt>cAt	p.R306H	VGLL2_uc003pxo.3_Missense_Mutation_p.R132H	NM_182645	NP_872586	Q8N8G2	VGLL2_HUMAN	Homo sapiens vestigial like 2 (Drosophila) (VGLL2), transcript variant 1, mRNA.	306					transcription, DNA-dependent	nucleus				central_nervous_system(1)|kidney(1)|lung(3)	5				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		TTTGCAGCTCGTCGTTATTCC	0.537000													7	323					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482242	142482242	+	Missense_Mutation	SNP	G	G	A	rs143538588	by1000genomes	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr7:142482242G>A	uc011ksq.2	+	4	705	c.622G>A	c.(622-624)Gga>Aga	p.G208R	TCRBV2S1_uc003vzp.2_Intron|TCRBV3S1_uc011ksh.2_Intron|TCRBV3S1_uc003vzw.2_Intron|TCRBV3S1_uc011ksi.2_Intron|TCRBV3S1_uc010loj.2_Intron|TCRBV3S1_uc003wag.2_Intron|BV6S4-BJ2S2_uc003wan.1_Intron					Homo sapiens protease, serine, 3 pseudogene (TRY6), non-coding RNA.																		GGTCTGCAATGGACAGCTTCA	0.493000													4	85					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28986327	28986327	+	Silent	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr18:28986327C>T	uc002kwr.2	+	11	2059	c.1924C>T	c.(1924-1926)Cta>Tta	p.L642L	DSG4_uc002kwq.2_Silent_p.L642L	NM_001134453	NP_001127925	Q86SJ6	DSG4_HUMAN	Homo sapiens desmoglein 4 (DSG4), transcript variant 1, mRNA.	642					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGGCATCCTGCTACTGATTTG	0.458000													23	89					0	0	1	0	0
FAM176B	55194	broad.mit.edu	37	1	36788016	36788016	+	Silent	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr1:36788016C>T	uc001caj.1	-	2	670	c.378G>A	c.(376-378)gaG>gaA	p.E126E	SH3D21_uc010oic.1_Non-coding_Transcript|FAM176B_uc001cai.1_Silent_p.E126E	NM_018166	NP_060636	Q9NVM1	F176B_HUMAN	Homo sapiens family with sequence similarity 176, member B (FAM176B), mRNA.	126						integral to membrane				lung(1)|pancreas(1)	2						GTTCGCGCTCCTCCAGCCGCT	0.746000													6	20					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3113516	3113516	+	Silent	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:3113516C>T	uc010jni.3	+	10	2191	c.1959C>T	c.(1957-1959)ctC>ctT	p.L653L	RIPK1_uc003muv.4_Silent_p.L490L|RIPK1_uc003mux.3_Silent_p.L653L|RIPK1_uc011dhs.2_Silent_p.L607L	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mRNA.	653	Death.				MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|activation of JUN kinase activity|activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of anti-apoptosis|positive regulation of interleukin-8 production|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CCCAGGCGCTCCACCAGTGTT	0.547000													5	47					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653656	46653656	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr22:46653656C>G	uc003bhh.3	-	0	5564	c.5564G>C	c.(5563-5565)gGa>gCa	p.G1855A		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	Homo sapiens polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin) (PKDREJ), mRNA.	1855					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATAAGTAAATCCATTGGTACT	0.388000													31	121					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14804406	14804406	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr12:14804406C>G	uc001rcd.3	-	14	1782	c.1645G>C	c.(1645-1647)Ggc>Cgc	p.G549R		NM_004963	NP_004954	P25092	GUC2C_HUMAN	Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor) (GUCY2C), mRNA.	549	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.G549C(2)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TTCACTGTGCCGTAGAACTTG	0.403000													10	42					0	0	1	0	0
IFFO1	25900	broad.mit.edu	37	12	6657960	6657960	+	Missense_Mutation	SNP	C	C	T	rs149041603		TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr12:6657960C>T	uc010sfe.2	-	5	1190	c.1136G>A	c.(1135-1137)cGc>cAc	p.R379H	IFFO1_uc001qoy.3_Non-coding_Transcript|IFFO1_uc001qoz.2_Missense_Mutation_p.R8H|IFFO1_uc001qpa.2_Missense_Mutation_p.R8H|IFFO1_uc001qpb.1_Missense_Mutation_p.R45H|IFFO1_uc001qpc.2_Missense_Mutation_p.R371H|IFFO1_uc001qpf.2_Missense_Mutation_p.R371H|IFFO1_uc001qpe.2_Non-coding_Transcript|IFFO1_uc001qpg.3_Missense_Mutation_p.R8H	NM_001193457	NP_001180386	Q0D2I5	IFFO1_HUMAN	Homo sapiens intermediate filament family orphan 1 (IFFO1), transcript variant 5, mRNA.	368						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						GGCAGCCTTGCGCTCCCGCTT	0.657000													3	31					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14162942	14162942	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:14162942C>T	uc002mxx.3	+	13	2174	c.1751C>T	c.(1750-1752)cCc>cTc	p.P584L		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	Homo sapiens interleukin 27 receptor, alpha (IL27RA), mRNA.	584					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						GGGGACTTGCCCATCCTGGAA	0.652000													7	21					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68024898	68024898	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr16:68024898C>A	uc010cey.3	-	5	899	c.735G>T	c.(733-735)aaG>aaT	p.K245N	DPEP2_uc002eve.3_Missense_Mutation_p.K245N|DPEP2_uc002evf.3_Intron	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	Homo sapiens dipeptidase 2 (DPEP2), mRNA.	245					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CTGCCACCACCTTCTGCAGGG	0.527000													41	102					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52520088	52520088	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:52520088T>C	uc002pyj.3	-	4	1165	c.763A>G	c.(763-765)Aca>Gca	p.T255A	ZNF614_uc002pyi.4_Intron|ZNF614_uc010epj.3_5'UTR	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	Homo sapiens zinc finger protein 614 (ZNF614), mRNA.	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		ATTTTGTCTGTTGTATTAGTT	0.353000													15	53					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:58385546G>T	uc002qqo.2	-	2	1484	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.2_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	Homo sapiens zinc finger protein 814 (ZNF814), mRNA.	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(20)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													5	14					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2161134	2161134	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr16:2161134A>C	uc002cos.1	-	14	4243	c.4034T>G	c.(4033-4035)gTg>gGg	p.V1345G	TCRBV20S1_uc021tak.1_Intron|PKD1_uc002cot.1_Missense_Mutation_p.V1345G	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	Homo sapiens polycystic kidney disease 1 (autosomal dominant) (PKD1), transcript variant 1, mRNA.	1345	PKD 8.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTTGTGTGTCACCGTCGGGCA	0.667000													18	45					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239160327	239160327	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr2:239160327C>A	uc002vyc.3	-	19	3424	c.3187G>T	c.(3187-3189)Gag>Tag	p.E1063*	PER2_uc010znv.1_Nonsense_Mutation_p.E1063*	NM_022817	NP_073728	O15055	PER2_HUMAN	Homo sapiens period homolog 2 (Drosophila) (PER2), mRNA.	1063					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		CAGAGGTCCTCATTCAGCAGG	0.607000													5	77					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22951198	22951198	+	Silent	SNP	G	G	A	rs147397251		TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:22951198G>A	uc021urt.1	-	2	290	c.135C>T	c.(133-135)atC>atT	p.I45I		NM_001080409	NP_001073878			Homo sapiens zinc finger protein 99 (ZNF99), mRNA.									p.I66I(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAGAGACAGCGATACCTGttt	0.333000													16	33					0	0	1	0	0
C6orf89	221477	broad.mit.edu	37	6	36887410	36887410	+	Silent	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:36887410C>T	uc003omw.3	+	6	1066	c.903C>T	c.(901-903)ctC>ctT	p.L301L	C6orf89_uc003omv.3_Silent_p.L188L|C6orf89_uc003omx.3_Silent_p.L294L|C6orf89_uc011dtr.2_Silent_p.L188L	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	Homo sapiens chromosome 6 open reading frame 89 (C6orf89), mRNA.	294						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						TGTTGCAGCTCATCCCTCCCT	0.532000													10	89					0	0	1	0	0
CDC25B	994	broad.mit.edu	37	20	3785591	3785591	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr20:3785591C>T	uc002wjn.3	+	15	2504	c.1726C>T	c.(1726-1728)Cgg>Tgg	p.R576W	CDC25B_uc010zqk.2_Missense_Mutation_p.R512W|CDC25B_uc010zql.2_Missense_Mutation_p.R498W|CDC25B_uc010zqm.2_Missense_Mutation_p.R485W|CDC25B_uc002wjl.3_Missense_Mutation_p.R464W|CDC25B_uc002wjm.3_Missense_Mutation_p.R464W|CDC25B_uc021waa.1_Missense_Mutation_p.R423W|CDC25B_uc002wjo.3_Missense_Mutation_p.R562W|CDC25B_uc002wjp.3_Missense_Mutation_p.R535W|CDC25B_uc002wjq.3_Missense_Mutation_p.R376W	NM_021873	NP_068659	P30305	MPIP2_HUMAN	Homo sapiens cell division cycle 25 homolog B (S. pombe) (CDC25B), transcript variant 1, mRNA.	576					G2/M transition of mitotic cell cycle|cell division|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						GCTCTGTAGCCGGCTGCAGGA	0.672000													7	78					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20056686	20056686	+	Splice_Site	SNP	T	T	C			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr13:20056686T>C	uc001umd.3	-	5	331	c.120_splice	c.e5-1	p.S40_splice	TPTE2_uc009zzk.3_Intron|TPTE2_uc009zzl.3_Splice_Site_p.S40_splice|TPTE2_uc001ume.3_Intron|TPTE2_uc009zzm.3_Intron|TPTE2_uc010tcm.2_Splice_Site	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	Homo sapiens transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (TPTE2), transcript variant 3, mRNA.	40						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTTCTAACATACTTTAGCCA	0.313000													4	66					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr17:39296167A>G	uc010cxk.2	-	0	573	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976	NP_112238	Q9BYQ5	KRA46_HUMAN	Homo sapiens keratin associated protein 4-6 (KRTAP4-6), mRNA.	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	11					0	0	1	0	0
RNF13	11342	broad.mit.edu	37	3	149563860	149563860	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr3:149563860A>G	uc003exn.4	+	2	831	c.47A>G	c.(46-48)tAc>tGc	p.Y16C	RNF13_uc003exp.4_Missense_Mutation_p.Y16C	NM_007282	NP_899237	O43567	RNF13_HUMAN	Homo sapiens ring finger protein 13 (RNF13), transcript variant 1, mRNA.	16					protein autoubiquitination	Golgi membrane|endoplasmic reticulum membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	11		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			ACACAAGTCTACACCATCTTG	0.428000													17	50					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680909	100680909	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr7:100680909C>T	uc003uxp.1	+	2	6265	c.6212C>T	c.(6211-6213)tCc>tTc	p.S2071F	MUC17_uc010lho.1_Non-coding_Transcript	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	Homo sapiens mucin 17, cell surface associated (MUC17), mRNA.	2071	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTTGACTCCAAAACTCAG	0.488000													83	215					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124160	12124160	+	Missense_Mutation	SNP	A	A	G	rs147240117	by1000genomes	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:12124160A>G	uc003nac.3	+	3	4311	c.4132A>G	c.(4132-4134)Atg>Gtg	p.M1378V	HIVEP1_uc011diq.2_Non-coding_Transcript	NM_002114	NP_002105	P15822	ZEP1_HUMAN	Homo sapiens human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1), mRNA.	1378					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCAAACGTCAATGGAGGTCTC	0.468000													12	97					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482229	142482229	+	Silent	SNP	T	T	A	rs145494190	by1000genomes	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr7:142482229T>A	uc011ksq.2	+	4	692	c.609T>A	c.(607-609)ccT>ccA	p.P203P	TCRBV2S1_uc003vzp.2_Intron|TCRBV3S1_uc011ksh.2_Intron|TCRBV3S1_uc003vzw.2_Intron|TCRBV3S1_uc011ksi.2_Intron|TCRBV3S1_uc010loj.2_Intron|TCRBV3S1_uc003wag.2_Intron|BV6S4-BJ2S2_uc003wan.1_Intron					Homo sapiens protease, serine, 3 pseudogene (TRY6), non-coding RNA.									p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													4	82					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574345	140574345	+	Silent	SNP	C	C	T	rs146513187	byFrequency	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr5:140574345C>T	uc003lix.3	+	0	2394	c.2220C>T	c.(2218-2220)gaC>gaT	p.D740D		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	Homo sapiens protocadherin beta 10 (PCDHB10), mRNA.	740					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.V739L(1)		breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCTGGTGGACGTGAGGGGCG	0.627000													5	189					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19565661	19565661	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr20:19565661C>T	uc002wrl.3	+	4	667	c.470C>T	c.(469-471)gCg>gTg	p.A157V		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	Homo sapiens solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (SLC24A3), mRNA.	157						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTCATGGCAGCGGGAAGTTCG	0.547000													5	98					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165414095	165414095	+	Silent	SNP	G	G	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr1:165414095G>T	uc001gda.3	-	0	498	c.36C>A	c.(34-36)ccC>ccA	p.P12P	RXRG_uc021pea.1_5'UTR|RXRG_uc001gdb.2_Non-coding_Transcript	NM_006917	NP_008848	P48443	RXRG_HUMAN	Homo sapiens retinoid X receptor, gamma (RXRG), transcript variant 1, mRNA.	12	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CATAGCCTGCGGGAAACTTCA	0.448000													8	44					0	0	1	0	0
RSAD1	55316	broad.mit.edu	37	17	48559551	48559551	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr17:48559551G>A	uc002iqw.1	+	3	630	c.574G>A	c.(574-576)Gtg>Atg	p.V192M	RSAD1_uc010wmq.1_Non-coding_Transcript	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	Homo sapiens radical S-adenosyl methionine domain containing 1 (RSAD1), mRNA.	192					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding	p.V192M(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCCCGGGCGCGTGTCTGTAGA	0.667000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	76					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16436741	16436741	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr9:16436741C>T	uc003zml.3	-	5	1591	c.1451G>A	c.(1450-1452)cGa>cAa	p.R484Q	BNC2_uc011lmw.2_Missense_Mutation_p.R389Q|BNC2_uc003zmm.3_Missense_Mutation_p.R442Q|BNC2_uc003zmq.1_Missense_Mutation_p.R498Q|BNC2_uc003zmr.1_Missense_Mutation_p.R521Q|BNC2_uc003zmp.1_Missense_Mutation_p.R512Q|BNC2_uc010mij.1_Missense_Mutation_p.R406Q|BNC2_uc011lmv.2_Missense_Mutation_p.R310Q|BNC2_uc003zmo.1_Missense_Mutation_p.R406Q|BNC2_uc003zmj.3_Missense_Mutation_p.R249Q|BNC2_uc003zmk.3_Non-coding_Transcript|BNC2_uc003zmi.3_Missense_Mutation_p.R249Q|BNC2_uc003zmn.1_Missense_Mutation_p.R249Q	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	Homo sapiens basonuclin 2 (BNC2), mRNA.	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		ATTACGACTTCGGAGGGAGCT	0.448000													10	105					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31023729	31023729	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr20:31023729G>A	uc021wbw.1	+	12	3646	c.3214G>A	c.(3214-3216)Gtc>Atc	p.V1072I	ASXL1_uc002wxs.3_Missense_Mutation_p.V1071I|ASXL1_uc010geb.3_Missense_Mutation_p.V963I	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	Homo sapiens additional sex combs like 1 (Drosophila) (ASXL1), transcript variant 1, mRNA.	1072					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.A1071A(1)|p.(574_1542)fs*?(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AGTATGTGCGGTCCGCCAAAA	0.567000			"""F, N, Mis"""		"""MDS, CMML"""								4	179					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37816139	37816139	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr5:37816139C>A	uc011cpi.2	-	2	450	c.250G>T	c.(250-252)Gca>Tca	p.A84S	GDNF_uc011cpd.2_Missense_Mutation_p.A32S|GDNF_uc011cpe.2_Missense_Mutation_p.A58S|GDNF_uc011cpf.2_Missense_Mutation_p.A58S|GDNF_uc011cpg.2_Missense_Mutation_p.A101S|GDNF_uc011cph.2_Missense_Mutation_p.A75S	NM_000514	NP_000505	P39905	GDNF_HUMAN	Homo sapiens glial cell derived neurotrophic factor (GDNF), transcript variant 1, mRNA.	84					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					GGAAGCACTGCCATTTGTTTA	0.483000													11	93					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232902	21232902	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr2:21232902G>A	uc002red.3	-	25	6966	c.6838C>T	c.(6838-6840)Cac>Tac	p.H2280Y		NM_000384	NP_000375	P04114	APOB_HUMAN	Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB), mRNA.	2280					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCAGCTAGGTGCTGGATGTCT	0.348000													39	89					0	0	1	0	0
CERS2	29956	broad.mit.edu	37	1	150938748	150938748	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr1:150938748C>T	uc001evy.3	-	10	1445	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H	CERS2_uc001evz.3_Missense_Mutation_p.R340H|CERS2_uc009wmh.3_Missense_Mutation_p.R190H	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	Homo sapiens ceramide synthase 2 (CERS2), transcript variant 1, mRNA.	340						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CCGGTCACTGCGTTCATCTTC	0.542000													25	62					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155572137	155572137	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:155572137C>A	uc003qqb.3	+	23	5315	c.4042C>A	c.(4042-4044)Ctt>Att	p.L1348I	TIAM2_uc003qqe.3_Missense_Mutation_p.L1348I|TIAM2_uc010kjj.3_Missense_Mutation_p.L910I|TIAM2_uc003qqf.3_Missense_Mutation_p.L724I|TIAM2_uc011efl.1_Missense_Mutation_p.L684I|TIAM2_uc003qqg.3_Missense_Mutation_p.L660I|TIAM2_uc003qqh.3_Missense_Mutation_p.L273I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	Homo sapiens T-cell lymphoma invasion and metastasis 2 (TIAM2), transcript variant 1, mRNA.	1348	PH 2.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	Rho guanyl-nucleotide exchange factor activity|receptor signaling protein activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TAGAAAGGACCTTGAGCTCAC	0.453000													32	95					0	0	1	0	0
HTR2B	3357	broad.mit.edu	37	2	231988403	231988403	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr2:231988403C>G	uc002vro.3	-	1	581	c.76G>C	c.(76-78)Gtt>Ctt	p.V26L	PSMD1_uc002vrn.2_Intron|PSMD1_uc002vrm.2_Intron|PSMD1_uc010fxu.2_Intron|HTR2B_uc010fxv.3_Missense_Mutation_p.V26L	NM_000867	NP_000858	P41595	5HT2B_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B (HTR2B), mRNA.	26					ERK1 and ERK2 cascade|G-protein coupled receptor internalization|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cGMP biosynthetic process|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|embryonic morphogenesis|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	G-protein alpha-subunit binding|Ras GTPase activator activity|calcium channel activity|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	11		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	GAAGAGATAACGTGAACAAAG	0.418000													12	146					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551554	248551554	+	Silent	SNP	T	T	C			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr1:248551554T>C	uc001iei.1	+	0	645	c.645T>C	c.(643-645)acT>acC	p.T215T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily T, member 6 (OR2T6), mRNA.	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGGTGGTGACTGCATCCTACA	0.532000													8	83					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19203914	19203914	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr1:19203914delC	uc001bbb.3	-	9	1409	c.1133delG	c.(1132-1134)ggcfs	p.G378fs	ALDH4A1_uc010ocu.2_Frame_Shift_Del_p.G318fs|ALDH4A1_uc001bbc.3_Frame_Shift_Del_p.G378fs|ALDH4A1_uc021ohl.1_Frame_Shift_Del_p.G378fs	NM_170726	NP_001154976	P30038	AL4A1_HUMAN	Homo sapiens aldehyde dehydrogenase 4 family, member A1 (ALDH4A1), nuclear gene encoding mitochondrial protein, transcript variant P5CDhS, mRNA.	378					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	ACTCACGTCGCCCACTTTGAT	0.701													2	4	---	---	---	---					
CHDH	55349	broad.mit.edu	37	3	53852145	53852145	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr3:53852145delG	uc003dgz.3	-	8	1885	c.1444delC	c.(1444-1446)cgafs	p.R482fs		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	Homo sapiens choline dehydrogenase (CHDH), nuclear gene encoding mitochondrial protein, mRNA.	482					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	TCTTTCCCTCGGAACGGAGCC	0.522													17	103	---	---	---	---					
C6	729	broad.mit.edu	37	5	41181559	41181560	+	Frame_Shift_Ins	INS	-	-	C			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr5:41181559_41181560insC	uc003jmk.2	-	6	1038_1039	c.828_829insG	c.(826-831)gggagcfs	p.G276fs	C6_uc003jml.1_Frame_Shift_Ins_p.G276fs	NM_000065	NP_001108603	P13671	CO6_HUMAN	Homo sapiens complement component 6 (C6), transcript variant 1, mRNA.	276	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.G275G(1)		central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTGAAAGAGCTCCCCCCCTGAC	0.376													8	82	---	---	---	---					
LMAN2	10960	broad.mit.edu	37	5	176778547	176778547	+	Frame_Shift_Del	DEL	A	A	-			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr5:176778547delA	uc003mge.3	-	0	339	c.102delT	c.(100-102)tttfs	p.F34fs		NM_006816	NP_006807	Q12907	LMAN2_HUMAN	Homo sapiens lectin, mannose-binding 2 (LMAN2), mRNA.	34					protein transport	ER-Golgi intermediate compartment membrane|Golgi membrane|endoplasmic reticulum membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAAAAGAAGAAAGAGAGGTG	0.602													11	51	---	---	---	---					
BTN2A3P	54718	broad.mit.edu	37	6	26422388	26422390	+	In_Frame_Del	DEL	CCT	CCT	-	rs113134648		TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr6:26422388_26422390delCCT	uc011dkl.1	+	0	72_74	c.42_44delCCT	c.(40-45)tccctc>tcc	p.L19del	BTN2A3P_uc011dkm.2_Non-coding_Transcript					Homo sapiens butyrophilin, subfamily 2, member A3, pseudogene (BTN2A3P), non-coding RNA.																		GGCCAGCCTCCCTCCTCCTCCTC	0.586													9	197	---	---	---	---					
BNC2	54796	broad.mit.edu	37	9	16436375	16436375	+	Frame_Shift_Del	DEL	G	G	-	rs116528562	byFrequency	TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr9:16436375delG	uc003zml.3	-	5	1957	c.1817delC	c.(1816-1818)ccgfs	p.P606fs	BNC2_uc011lmw.2_Frame_Shift_Del_p.P511fs|BNC2_uc003zmm.3_Frame_Shift_Del_p.P564fs|BNC2_uc003zmq.1_Frame_Shift_Del_p.P620fs|BNC2_uc003zmr.1_Frame_Shift_Del_p.P643fs|BNC2_uc003zmp.1_Frame_Shift_Del_p.P634fs|BNC2_uc010mij.1_Frame_Shift_Del_p.P528fs|BNC2_uc011lmv.2_Frame_Shift_Del_p.P432fs|BNC2_uc003zmo.1_Frame_Shift_Del_p.P528fs|BNC2_uc003zmj.3_Frame_Shift_Del_p.P371fs|BNC2_uc003zmk.3_Non-coding_Transcript|BNC2_uc003zmi.3_Frame_Shift_Del_p.P371fs|BNC2_uc003zmn.1_Frame_Shift_Del_p.P371fs	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	Homo sapiens basonuclin 2 (BNC2), mRNA.	606	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		AGAGGGTGGCGGGGGGTGCTG	0.562													28	127	---	---	---	---					
KANK3	256949	broad.mit.edu	37	19	8398950	8398961	+	In_Frame_Del	DEL	TCGCTGTCGCCA	TCGCTGTCGCCA	-	rs111751275		TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr19:8398950_8398961delTCGCTGTCGCCA	uc010dwa.3	-	4	1533_1544	c.1467_1478delTGGCGACAGCGA	c.(1465-1479)gatggcgacagcgag>gag	p.DGDS489del	KANK3_uc002mjp.1_In_Frame_Del_p.MATA1del	NM_198471	NP_940873	Q6NY19	KANK3_HUMAN	Homo sapiens KN motif and ankyrin repeat domains 3 (KANK3), mRNA.	489								p.D489_S492delDGDS(4)		breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GCCACCGTTCTCGCTGTCGCCATCGCTGTCGC	0.717													3	4	---	---	---	---					
SLC19A1	6573	broad.mit.edu	37	21	46950724	46950727	+	Frame_Shift_Del	DEL	GCAC	GCAC	-			TCGA-J4-A67K-01A-21D-A30E-08	TCGA-J4-A67K-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	68e09db6-a35c-43fc-ac1f-c5b66bb3ae2b	838d6528-8be3-48aa-887b-614a711bddf4	g.chr21:46950724_46950727delGCAC	uc002zhl.2	-	3	1261_1264	c.1108_1111delGTGC	c.(1108-1113)gtgctgfs	p.V370fs	SLC19A1_uc010gpy.1_Frame_Shift_Del_p.V370fs|SLC19A1_uc011aft.2_Frame_Shift_Del_p.V330fs|SLC19A1_uc002zhm.2_Frame_Shift_Del_p.V370fs|SLC19A1_uc010gpz.2_Frame_Shift_Del_p.V249fs	NM_194255	NP_919231	P41440	S19A1_HUMAN	Homo sapiens solute carrier family 19 (folate transporter), member 1 (SLC19A1), transcript variant 1, mRNA.	370					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CCGCGGAACAGCACGAAGGCCGCA	0.696													3	4	---	---	---	---					
