Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF232	7775	broad.mit.edu	37	17	5009595	5009595	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr17:5009595T>C	uc002gat.3	-	4	1514	c.859A>G	c.(859-861)Agg>Ggg	p.R287G	ZNF232_uc002gar.1_Missense_Mutation_p.R278G	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	Homo sapiens zinc finger protein 232 (ZNF232), mRNA.	260					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						ACCATCTGCCTGAAACTTTCC	0.453000													4	111					0	0	1	0	0
WASH6P	653440	broad.mit.edu	37	X	155255036	155255036	+	Silent	SNP	C	C	G			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chrX:155255036C>G	uc022cip.1	+	6	996	c.792C>G	c.(790-792)tcC>tcG	p.S264S						RecName: Full=WAS protein family homolog 6; AltName: Full=Protein FAM39A;									p.S478S(1)									ACTGGGAATCCTAGGGGGCTC	0.642000													4	32					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13346468	13346468	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr19:13346468G>T	uc002mwy.3	-	31	5263	c.5027C>A	c.(5026-5028)aCc>aAc	p.T1676N	CACNA1A_uc002mwx.3_Missense_Mutation_p.T382N|CACNA1A_uc010dzc.2_Missense_Mutation_p.T1202N|CACNA1A_uc010xnd.2_Missense_Mutation_p.T1679N|CACNA1A_uc021ups.1_Missense_Mutation_p.T1676N|CACNA1A_uc010xne.2_Missense_Mutation_p.T1679N|CACNA1A_uc010dze.2_Missense_Mutation_p.T1676N|CACNA1A_uc021upt.1_Missense_Mutation_p.T1677N|CACNA1A_uc002mwv.3_Missense_Mutation_p.T193N	NM_001127222	NP_001120694	O00555	CAC1A_HUMAN	Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 4, mRNA.	1677					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AATGCGGATGGTGTAACCCTG	0.562000											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	80					0	0	1	0	0
PANK1	53354	broad.mit.edu	37	10	91371708	91371708	+	Silent	SNP	C	C	G			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr10:91371708C>G	uc001kgp.2	-	1	1071	c.801G>C	c.(799-801)gtG>gtC	p.V267V	PANK1_uc001kgn.2_Silent_p.V42V|PANK1_uc001kgo.2_Silent_p.V42V|PANK1_uc009xtu.2_Silent_p.V69V	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	Homo sapiens pantothenate kinase 1 (PANK1), transcript variant alpha, mRNA.	267					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	TCAGGTTCTCCACTTCCTCTT	0.473000													11	79					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37903970	37903970	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr7:37903970A>C	uc003tfn.3	+	8	847	c.475A>C	c.(475-477)Att>Ctt	p.I159L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	Homo sapiens thioredoxin domain containing 3 (spermatozoa) (TXNDC3), mRNA.	159	NDK 1.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process|cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										CAGTATTGCTATTATCAAACC	0.279000													3	13					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90178510	90178510	+	Silent	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr1:90178510C>T	uc001dnl.4	+	2	623	c.381C>T	c.(379-381)ttC>ttT	p.F127F		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member C (LRRC8C), mRNA.	127						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CCAAGTATTTCCCTTACCTTG	0.433000													14	150					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345964	92345964	+	Silent	SNP	G	G	A	rs147274494		TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr13:92345964G>A	uc010tif.2	+	2	1215	c.849G>A	c.(847-849)gcG>gcA	p.A283A		NM_004466	NP_004457	P78333	GPC5_HUMAN	Homo sapiens glypican 5 (GPC5), mRNA.	283						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding	p.L282L(1)		NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCTGCCTGGCGCACATGGCGG	0.552000													13	84					0	0	1	0	0
PRIC285	85441	broad.mit.edu	37	20	62196338	62196338	+	Silent	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr20:62196338C>T	uc002yfm.2	-	8	4729	c.3837G>A	c.(3835-3837)ccG>ccA	p.P1279P	PRIC285_uc002yfl.1_Silent_p.P710P	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	Homo sapiens peroxisomal proliferator-activated receptor A interacting complex 285 (PRIC285), transcript variant 1, mRNA.	1279					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|RNA binding|helicase activity|ribonuclease activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(4)|cervix(3)|endometrium(6)|kidney(3)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(4)|urinary_tract(2)	47	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CGATGCCCAGCGGGTAGTAGA	0.687000													3	28					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863147	85863147	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr9:85863147A>C	uc004ams.2	-	13	1682	c.1480T>G	c.(1480-1482)Ttg>Gtg	p.L494V	FRMD3_uc004amr.1_Missense_Mutation_p.L494V|FRMD3_uc022bja.1_Missense_Mutation_p.L450V|FRMD3_uc004amq.1_Missense_Mutation_p.L151V|FRMD3_uc022biz.1_Missense_Mutation_p.L300V	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	Homo sapiens FERM domain containing 3 (FRMD3), transcript variant 1, mRNA.	494						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						TCAGCAATCAAAAAGGCGTTT	0.478000													20	150					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29395335	29395335	+	Silent	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr6:29395335C>T	uc003nmg.3	-	0	175	c.84G>A	c.(82-84)ttG>ttA	p.L28L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily A, member 1 (OR11A1), mRNA.	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CAATAAAAAACAAGAAATGCA	0.408000													4	83					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42035035	42035035	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr15:42035035C>T	uc010ucy.2	+	14	5058	c.4877C>T	c.(4876-4878)aCt>aTt	p.T1626I	MGA_uc010ucz.2_Intron|MGA_uc010uda.1_Missense_Mutation_p.T242I	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	Homo sapiens MAX gene associated (MGA), transcript variant 1, mRNA.	1626	Thr-rich.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ACTAAAGAAACTACTTATTCT	0.448000													8	78					0	0	1	0	0
COBRA1	25920	broad.mit.edu	37	9	140157669	140157669	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr9:140157669C>T	uc004cmm.4	+	4	981	c.778C>T	c.(778-780)Cac>Tac	p.H260Y		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	Homo sapiens cofactor of BRCA1 (COBRA1), mRNA.	260					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding			endometrium(2)|large_intestine(5)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	16	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		GGACCCGTGCCACAAGGTAGC	0.662000													11	67					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814182	123814182	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr11:123814182G>A	uc010sab.2	-	0	364	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily T, member 1 (OR6T1), mRNA.	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122S(2)|p.R122C(2)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GCCAGGTAACGATCCAGAGAC	0.527000													3	34					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91406702	91406702	+	Missense_Mutation	SNP	T	T	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr1:91406702T>A	uc001dnw.3	-	2	492	c.209A>T	c.(208-210)aAt>aTt	p.N70I	ZNF644_uc001dnv.3_Intron|ZNF644_uc001dnx.3_Intron|ZNF644_uc001dny.2_Missense_Mutation_p.N70I	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA.	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGTCAACGTATTATTTTTCTG	0.393000													14	94					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64559403	64559403	+	Silent	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr11:64559403C>T	uc001obh.3	-	26	2162	c.2070G>A	c.(2068-2070)acG>acA	p.T690T	MAP4K2_uc001obi.3_Silent_p.T682T	NM_004579	NP_004570	Q12851	M4K2_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), mRNA.	690	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	Golgi membrane|basolateral plasma membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						GGATGTCGGGCGTCAGGCCAG	0.692000													5	7					0	0	1	0	0
DTX2P1-UPK3BP1-PMS2P11	441263	broad.mit.edu	37	7	76610521	76610521	+	RNA	SNP	C	C	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr7:76610521C>A	uc011kgn.1	+	0		c.383C>A			DTX2P1-UPK3BP1-PMS2P11_uc003ufw.4_Non-coding_Transcript					Homo sapiens DTX2P1-UPK3BP1-PMS2P11 readthrough (non-protein coding) (DTX2P1-UPK3BP1-PMS2P11), non-coding RNA.																		GCTCCAGCCTCTCCCACCTGG	0.677000													8	70					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	369173	369173	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr12:369173G>A	uc001qic.2	-	1	136	c.46C>T	c.(46-48)Cca>Tca	p.P16S	SLC6A13_uc009zdj.2_Missense_Mutation_p.P16S|SLC6A13_uc010sdl.2_Missense_Mutation_p.P16S|SLC6A13_uc001qid.2_Missense_Mutation_p.P16S	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	Homo sapiens solute carrier family 6 (neurotransmitter transporter, GABA), member 13 (SLC6A13), transcript variant 1, mRNA.	16					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGATACACTGGTTTTGTCTCT	0.517000													20	179					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863145	85863145	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr9:85863145C>G	uc004ams.2	-	13	1684	c.1482G>C	c.(1480-1482)ttG>ttC	p.L494F	FRMD3_uc004amr.1_Missense_Mutation_p.L494F|FRMD3_uc022bja.1_Missense_Mutation_p.L450F|FRMD3_uc004amq.1_Missense_Mutation_p.L151F|FRMD3_uc022biz.1_Missense_Mutation_p.L300F	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	Homo sapiens FERM domain containing 3 (FRMD3), transcript variant 1, mRNA.	494						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CTTCAGCAATCAAAAAGGCGT	0.468000													20	148					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153136389	153136389	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chrX:153136389G>A	uc004fjb.3	-	5	658	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W	L1CAM_uc004fjc.3_Missense_Mutation_p.R184W|L1CAM_uc010nuo.3_Missense_Mutation_p.R179W|L1CAM_uc004fjd.1_5'UTR|L1CAM_uc022chz.1_Missense_Mutation_p.R179W	NM_000425	NP_000416	P32004	L1CAM_HUMAN	Homo sapiens L1 cell adhesion molecule (L1CAM), transcript variant 1, mRNA.	184	Ig-like C2-type 2.		R -> Q (in HSAS; severe).|R -> W (in HSAS).		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATCGTCACCCGCTCGTCCTGC	0.612000													16	74					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103416203	103416203	+	Silent	SNP	G	G	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr14:103416203G>T	uc001ymi.1	-	25	3580	c.3348C>A	c.(3346-3348)cgC>cgA	p.R1116R	CDC42BPB_uc001ymj.1_Silent_p.R218R	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	Homo sapiens CDC42 binding protein kinase beta (DMPK-like) (CDC42BPB), mRNA.	1116	PH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CTGCATATGCGCGCTGCCATC	0.557000													18	115					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73951097	73951097	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr4:73951097G>A	uc003hgp.3	-	29	7145	c.7028C>T	c.(7027-7029)gCt>gTt	p.A2343V	ANKRD17_uc003hgo.3_Missense_Mutation_p.A2230V|ANKRD17_uc003hgq.3_Missense_Mutation_p.A2092V|ANKRD17_uc003hgr.3_Missense_Mutation_p.A2342V	NM_032217	NP_115593	O75179	ANR17_HUMAN	Homo sapiens ankyrin repeat domain 17 (ANKRD17), transcript variant 1, mRNA.	2343					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATGTTTGAAGCAAAGTTTCC	0.428000													4	161					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98349377	98349377	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr2:98349377G>A	uc002syd.1	+	4	802	c.595G>A	c.(595-597)Gcc>Acc	p.A199T	ZAP70_uc010yvf.1_Missense_Mutation_p.A199T|ZAP70_uc002sye.1_Missense_Mutation_p.A89T|ZAP70_uc002syf.1_5'Flank	NM_001079	NP_997402	P43403	ZAP70_HUMAN	Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1, mRNA.	199	SH2 2.				T cell receptor signaling pathway|immune response|intracellular protein kinase cascade|positive thymic T cell selection	T cell receptor complex|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						GGGCACATACGCCCTGTCCCT	0.627000													5	59					0	0	1	0	0
LOC494141	494141	broad.mit.edu	37	11	18231202	18231202	+	RNA	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr11:18231202G>A	uc009yhh.3	+	1		c.226G>A			LOC494141_uc001mnx.4_Non-coding_Transcript|LOC494141_uc009yhi.2_Non-coding_Transcript					Homo sapiens mitochondrial carrier triple repeat 1 pseudogene (LOC494141), transcript variant 1, non-coding RNA.																		AAAAAAAAAAGAAAAAGTCCT	0.328000													8	17					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150699374	150699374	+	Silent	SNP	T	T	C			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr7:150699374T>C	uc003wif.3	+	13	2030	c.1734T>C	c.(1732-1734)gaT>gaC	p.D578D	NOS3_uc011kuy.2_Silent_p.D372D|NOS3_uc011kva.2_Silent_p.D578D|NOS3_uc011kuz.2_Silent_p.D578D|NOS3_uc011kvb.2_Silent_p.D578D	NM_000603	NP_000594	P29474	NOS3_HUMAN	Homo sapiens nitric oxide synthase 3 (endothelial cell) (NOS3), transcript variant 1, mRNA.	578	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	Golgi membrane|caveola|cytoskeleton|cytosol	FMN binding|NADP binding|actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|heme binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGAATGGGGATCCCCCGGAGA	0.562000													3	10					0	0	1	0	0
LOC440905	440905	broad.mit.edu	37	2	130786055	130786055	+	RNA	SNP	A	A	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr2:130786055A>T	uc002tpy.1	-	0		c.3437T>A			LOC440905_uc002tpz.2_Splice_Site					Homo sapiens uncharacterized LOC440905 (LOC440905), non-coding RNA.																		AGACCTGGAAACCTGGGGGAA	0.428000													3	4					0	0	1	0	0
TATDN1	83940	broad.mit.edu	37	8	125535240	125535240	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr8:125535240A>G	uc003yrd.2	-	1	68	c.26T>C	c.(25-27)aTt>aCt	p.I9T	TATDN1_uc003yre.2_Non-coding_Transcript|TATDN1_uc010mdm.2_Intron	NM_032026	NP_001139632	Q6P1N9	TATD1_HUMAN	Homo sapiens TatD DNase domain containing 1 (TATDN1), transcript variant 1, mRNA.	9						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	15	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GTTGATACCAATATCTGTAGA	0.328000													9	49					0	0	1	0	0
LOC440905	440905	broad.mit.edu	37	2	130786063	130786063	+	RNA	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr2:130786063G>A	uc002tpy.1	-	0		c.3429C>T			LOC440905_uc002tpz.2_Intron					Homo sapiens uncharacterized LOC440905 (LOC440905), non-coding RNA.																		AAACCTGGGGGAAAAAAGAGA	0.423000													3	5					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78328255	78328255	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr17:78328255G>A	uc002jyh.2	+	36	11031	c.10888G>A	c.(10888-10890)Gta>Ata	p.V3630I	RNF213_uc021uen.1_Missense_Mutation_p.V3581I|LOC100294362_uc002jyi.2_3'UTR	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	SubName: Full=Uncharacterized protein;	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TTTCTTGCGGGTATCCAAGAT	0.552000													11	96					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44144631	44144631	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr6:44144631C>A	uc003owt.1	+	10	1171	c.1133C>A	c.(1132-1134)aCg>aAg	p.T378K	CAPN11_uc011dvn.2_Missense_Mutation_p.T32K	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	Homo sapiens calpain 11 (CAPN11), mRNA.	378	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCAACCTCACGCCTGATACA	0.597000													6	263					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4910802	4910802	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr16:4910802C>T	uc002cyb.3	+	6	1148	c.809C>T	c.(808-810)gCg>gTg	p.A270V	UBN1_uc010uxw.2_Missense_Mutation_p.A270V|UBN1_uc002cyc.3_Missense_Mutation_p.A270V	NM_001079514	NP_058632	Q9NPG3	UBN1_HUMAN	Homo sapiens ubinuclein 1 (UBN1), transcript variant 2, mRNA.	270					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						AAGCCTGTTGCGGTCCCATCA	0.498000													4	113					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69097585	69097585	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr3:69097585C>T	uc011bfx.2	-	1	518	c.271G>A	c.(271-273)Gat>Aat	p.D91N	TMF1_uc003dnn.3_Missense_Mutation_p.D91N	NM_007114	NP_009045	P82094	TMF1_HUMAN	Homo sapiens TATA element modulatory factor 1 (TMF1), mRNA.	91					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TCAGATTCATCGACCACAGTC	0.463000													31	229					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784063	9784063	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr4:9784063A>G	uc003gmb.4	+	0	806	c.410A>G	c.(409-411)gAc>gGc	p.D137G		NM_000798	NP_000789	P21918	DRD5_HUMAN	Homo sapiens dopamine receptor D5 (DRD5), mRNA.	137					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.D137G(2)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCAGCGTGGACCGCTACTGG	0.612000													3	44					0	0	1	0	0
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr3:100148586_100148588delGAT	uc003dtx.4	+	1	1293_1295	c.13_15delGAT	c.(13-15)gatdel	p.D10del		NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	Homo sapiens leukemia NUP98 fusion partner 1 (LNP1), mRNA.	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													7	412	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618431	89618433	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr4:89618431_89618433delCCT	uc003hrx.3	-	0	591_593	c.473_475delAGG	c.(472-477)gaggct>gct	p.E158del	HERC3_uc011cdn.1_Intron|HERC3_uc003hrw.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	Homo sapiens nucleosome assembly protein 1-like 5 (NAP1L5), mRNA.	158	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TCTGCCGCAGcctcctcctcctc	0.626													7	188	---	---	---	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr7:92146721delT	uc003uly.3	-	4	1204	c.1108delA	c.(1108-1110)attfs	p.I370fs	PEX1_uc011khr.2_Frame_Shift_Del_p.I162fs|PEX1_uc010ley.3_Frame_Shift_Del_p.I370fs|PEX1_uc011khs.2_Intron|PEX1_uc011kht.1_Non-coding_Transcript	NM_000466	NP_000457	O43933	PEX1_HUMAN	Homo sapiens peroxisomal biogenesis factor 1 (PEX1), mRNA.	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													8	120	---	---	---	---					
DHX37	57647	broad.mit.edu	37	12	125465270	125465272	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr12:125465270_125465272delCTC	uc001ugy.3	-	3	601_603	c.502_504delGAG	c.(502-504)gagdel	p.E168del		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 37 (DHX37), mRNA.	168							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.E168delE(6)		breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCGATTCCGActcctcctcctcc	0.690													3	6	---	---	---	---					
CACNA1A	773	broad.mit.edu	37	19	13441098	13441098	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J4-A67O-01A-11D-A30E-08	TCGA-J4-A67O-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86a0580e-36fc-4afd-ae47-966d6b1dc108	f8e39928-9a59-4e5a-ba1e-f22910129528	g.chr19:13441098delG	uc002mwy.3	-	9	1541	c.1305delC	c.(1303-1305)cccfs	p.P435fs	CACNA1A_uc010dzc.2_5'UTR|CACNA1A_uc010xnd.2_Frame_Shift_Del_p.P435fs|CACNA1A_uc021ups.1_Frame_Shift_Del_p.P435fs|CACNA1A_uc010xne.2_Frame_Shift_Del_p.P435fs|CACNA1A_uc010dze.2_Frame_Shift_Del_p.P435fs|CACNA1A_uc021upt.1_Frame_Shift_Del_p.P436fs	NM_001127222	NP_001120694	O00555	CAC1A_HUMAN	Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 4, mRNA.	436					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAGCCTCTTCGGGGTTGAGCA	0.488													2	4	---	---	---	---					
