Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC16	94025	broad.mit.edu	37	19	9073638	9073638	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:9073638C>T	uc002mkp.3	-	2	14012	c.13808G>A	c.(13807-13809)cGa>cAa	p.R4603Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	4605	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.R4603Q(5)|p.R236Q(2)|p.G4602G(1)|p.R4603*(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCTCTTTTCGTCCAGCAGT	0.502000													5	71					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013055	75013055	+	Silent	SNP	A	A	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr15:75013055A>T	uc002ayp.4	-	6	1436	c.1314T>A	c.(1312-1314)gcT>gcA	p.A438A	CYP1A1_uc010bjy.3_Silent_p.A409A|CYP1A1_uc010bju.3_Silent_p.A174A|CYP1A1_uc010bjv.3_Non-coding_Transcript|CYP1A1_uc010bjw.3_Non-coding_Transcript|CYP1A1_uc010bjx.3_Silent_p.A174A|CYP1A1_uc002ayq.4_Silent_p.A438A	NM_000499	NP_000490	P04798	CP1A1_HUMAN	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.	438					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity	p.A438V(1)		autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCTTGTCGATAGCACCATCAG	0.527000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				6	283					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6224992	6224992	+	Silent	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr6:6224992T>C	uc003mwv.3	-	6	1023	c.900A>G	c.(898-900)ctA>ctG	p.L300L	F13A1_uc011dib.2_Silent_p.L237L	NM_000129	NP_000120	P00488	F13A_HUMAN	Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA.	300					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGTATTCCAATAGAATGTCAA	0.478000													5	254					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180053141	180053141	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:180053141G>A	uc003mlz.4	-	8	1307	c.1228C>T	c.(1228-1230)Cgc>Tgc	p.R410C	FLT4_uc003mma.4_Missense_Mutation_p.R410C|FLT4_uc003mmb.1_5'UTR|FLT4_uc011dgy.2_Missense_Mutation_p.R410C	NM_182925	NP_891555	P35916	VGFR3_HUMAN	Homo sapiens fms-related tyrosine kinase 4 (FLT4), transcript variant 1, mRNA.	410	Ig-like C2-type 4.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGATGTTGCGCCTCAGGCCA	0.667000													17	197					0	0	1	0	0
CD69	969	broad.mit.edu	37	12	9913395	9913395	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr12:9913395C>T	uc001qwk.3	-	0	103	c.22G>A	c.(22-24)Gta>Ata	p.V8I	CD69_uc010sgu.2_Missense_Mutation_p.V8I|CD69_uc010sgv.1_Missense_Mutation_p.V8I	NM_001781	NP_001772	Q07108	CD69_HUMAN	Homo sapiens CD69 molecule (CD69), transcript variant 1, mRNA.	8						integral to plasma membrane	sugar binding|transmembrane receptor activity			endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10						TTCTCTGCTACGAAACAATTT	0.393000													4	174					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151489	158151489	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:158151489C>T	uc001frr.3	+	2	805	c.306C>T	c.(304-306)ttC>ttT	p.F102F	CD1D_uc009wsr.1_Silent_p.F102F|CD1D_uc009wss.3_Silent_p.F102F|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	Homo sapiens CD1d molecule (CD1D), mRNA.	102					T cell selection|antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGAAGGAATTCGCCAAAATGC	0.557000													9	133					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	977124	977124	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:977124C>T	uc001lst.2	+	4	716	c.503C>T	c.(502-504)gCg>gTg	p.A168V	AP2A2_uc009yco.2_Non-coding_Transcript|AP2A2_uc001lss.3_Missense_Mutation_p.A168V|AP2A2_uc001lsu.1_Missense_Mutation_p.A41V	NM_001242837	NP_001229766	O94973	AP2A2_HUMAN	Homo sapiens adaptor-related protein complex 2, alpha 2 subunit (AP2A2), transcript variant 1, mRNA.	168					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		AAGCAGAGCGCGGCCCTGTGC	0.612000													4	81					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75107127	75107127	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:75107127C>A	uc001dgg.3	-	4	551	c.332G>T	c.(331-333)aGg>aTg	p.R111M		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	Homo sapiens chromosome 1 open reading frame 173 (C1orf173), mRNA.	111										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCAACAGACCTTCTTGTGTG	0.408000													7	105					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	RNA	SNP	C	C	A	rs79307257	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593016C>A	uc010yug.1	-	26		c.1897G>T			ANKRD36C_uc002sva.1_Non-coding_Transcript|ANKRD36C_uc002svc.1_Non-coding_Transcript					Homo sapiens cDNA FLJ54441 complete cds, highly similar to Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	98					0	0	1	0	0
LZTS1	11178	broad.mit.edu	37	8	20107496	20107496	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr8:20107496C>T	uc003wzr.3	-	2	1639	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	LZTS1_uc010ltg.2_Intron	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	Homo sapiens leucine zipper, putative tumor suppressor 1 (LZTS1), mRNA.	510					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	Golgi apparatus|cell junction|dendritic spine|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TCCCGCAGCTCGGCCCGCAGC	0.701000													4	154					0	0	1	0	0
C20orf118	140711	broad.mit.edu	37	20	35504580	35504580	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:35504580G>C	uc002xgg.1	+	0	11	c.3G>C	c.(1-3)atG>atC	p.M1I	C20orf118_uc021wcz.1_Missense_Mutation_p.M1I	NM_080628	NP_542195	A0PJX2	CT118_HUMAN	Homo sapiens chromosome 20 open reading frame 118 (C20orf118), mRNA.	1										kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	9		Myeloproliferative disorder(115;0.00874)				ACAGGAGAATGAGAGGCCTCC	0.617000													7	284					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26094758	26094758	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:26094758C>T	uc002gzu.3	-	17	2404	c.2140G>A	c.(2140-2142)Gac>Aac	p.D714N	NOS2_uc010wab.1_Missense_Mutation_p.D679N	NM_000625	NP_000616	P35228	NOS2_HUMAN	Homo sapiens nitric oxide synthase 2, inducible (NOS2), mRNA.	714					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	FMN binding|NADP binding|arginine binding|calmodulin binding|flavin adenine dinucleotide binding|heme binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGCTGTGAGTCCTGCACGAGC	0.557000													8	65					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50682700	50682700	+	Silent	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr22:50682700T>C	uc003bkb.1	-	0	701	c.189A>G	c.(187-189)aaA>aaG	p.K63K	TUBGCP6_uc010har.1_Silent_p.K63K|TUBGCP6_uc010has.1_Non-coding_Transcript|TUBGCP6_uc010hau.1_Silent_p.K63K	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	Homo sapiens tubulin, gamma complex associated protein 6 (TUBGCP6), mRNA.	63					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCGCTGGTAGTTTTGACATGT	0.522000													14	165					0	0	1	0	0
C2orf55	343990	broad.mit.edu	37	2	99413924	99413924	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:99413924C>T	uc002szf.1	-	7	2787	c.2493G>A	c.(2491-2493)cgG>cgA	p.R831R		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	Homo sapiens chromosome 2 open reading frame 55 (C2orf55), mRNA.	831								p.R831R(2)		NS(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28						TCCGCTTCTGCCGAGTGACGG	0.612000													5	205					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904139	21904139	+	RNA	SNP	T	T	G			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:21904139T>G	uc002gza.2	+	0		c.78T>G								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ccgagcaggatgaggaaacca	0.692000													5	212					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084225	99084225	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:99084225A>C	uc003uqq.1	+	4	611	c.392A>C	c.(391-393)aAg>aCg	p.K131T	ZNF789_uc010lfw.1_Missense_Mutation_p.K36T|ZNF789_uc003uqr.1_Missense_Mutation_p.K73T	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	Homo sapiens zinc finger protein 789 (ZNF789), transcript variant 1, mRNA.	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGTTACATAAGTGTAAAGAA	0.368000													25	161					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176310790	176310790	+	Silent	SNP	G	G	A	rs140261586	byFrequency	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:176310790G>A	uc003mfa.3	-	14	2126	c.2034C>T	c.(2032-2034)tgC>tgT	p.C678C	HK3_uc003mez.3_Silent_p.C234C	NM_002115	NP_002106	P52790	HXK3_HUMAN	Homo sapiens hexokinase 3 (white cell) (HK3), nuclear gene encoding mitochondrial protein, mRNA.	678	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTATCTCGCAACGGGGGT	0.547000													6	142					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16577790	16577790	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:16577790G>A	uc001ayg.3	-	9	1745	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F	FBXO42_uc001ayf.3_Missense_Mutation_p.S417F	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	Homo sapiens F-box protein 42 (FBXO42), mRNA.	510										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ATTACTACTGGAAGCGGGTTT	0.483000													17	161					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52574519	52574519	+	Silent	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr12:52574519G>A	uc001rzw.3	-	1	600	c.549C>T	c.(547-549)ttC>ttT	p.F183F	KRT80_uc001rzy.3_Intron|KRT80_uc001rzx.3_Intron	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	Homo sapiens keratin 80 (KRT80), transcript variant 1, mRNA.	0	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		TCAGAGCCTCGAAAAAGGAGC	0.592000													5	29					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7286330	7286330	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:7286330G>A	uc002ggi.4	+	1	317	c.85G>A	c.(85-87)Gag>Aag	p.E29K	TNK1_uc002ggj.4_Missense_Mutation_p.E29K|TNK1_uc010cmf.3_Non-coding_Transcript	NM_001251902	NP_001238831	Q13470	TNK1_HUMAN	Homo sapiens tyrosine kinase, non-receptor, 1 (TNK1), transcript variant 1, mRNA.	29					protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				CATCCTTGAGGAGCTTAATGT	0.597000													6	100					0	0	1	0	0
BC063132	0	broad.mit.edu	37	GL000241.1	36849	36849	+	RNA	SNP	C	C	G			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chrGL000241.1:36849C>G	uc011mgv.2	-	0		c.27G>C								Homo sapiens cDNA clone IMAGE:4673444, containing frame-shift errors.																		CGGAGCAGCACCAGGGCGGGG	0.577000													3	22					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37132662	37132662	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:37132662C>T	uc001wty.4	+	2	1291	c.565C>T	c.(565-567)Ccg>Tcg	p.P189S	PAX9_uc010amq.3_5'Flank	NM_006194	NP_006185	P55771	PAX9_HUMAN	Homo sapiens paired box 9 (PAX9), mRNA.	189	Interaction with KDM5B.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		GGTGGCCATGCCGCGCACCTG	0.682000													4	117					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	RNA	SNP	A	A	G	rs111976783		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593000A>G	uc010yug.1	-	26		c.1913T>C			ANKRD36C_uc002sva.1_Non-coding_Transcript|ANKRD36C_uc002svc.1_Non-coding_Transcript					Homo sapiens cDNA FLJ54441 complete cds, highly similar to Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	95					0	0	1	0	0
TRA2A	29896	broad.mit.edu	37	7	23561395	23561395	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:23561395G>A	uc003swi.3	-	1	314	c.101C>T	c.(100-102)tCa>tTa	p.S34L	TRA2A_uc011jzb.2_Non-coding_Transcript|TRA2A_uc011jzc.2_5'UTR|TRA2A_uc011jzd.2_5'UTR|TRA2A_uc010kuo.1_Non-coding_Transcript	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	Homo sapiens transformer 2 alpha homolog (Drosophila) (TRA2A), mRNA.	34	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	RNA binding|nucleotide binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						ACGAGATCCTGACCTGCTCTC	0.418000													4	140					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47857211	47857211	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:47857211G>A	uc001ngm.3	-	6	1178	c.1093C>T	c.(1093-1095)Cga>Tga	p.R365*	NUP160_uc009ylw.3_Non-coding_Transcript|NUP160_uc021qiu.1_Nonsense_Mutation_p.R365*	NM_015231	NP_056046	Q12769	NU160_HUMAN	Homo sapiens nucleoporin 160kDa (NUP160), mRNA.	365					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|mitotic prometaphase|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|cytosol	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						ACCTGTCCTCGTTTTGGTGCA	0.448000													10	122					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623156	21623156	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:21623156C>T	uc010tlp.2	-	0	1029	c.1029G>A	c.(1027-1029)ttG>ttA	p.L343L		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily AU, member 1 (OR5AU1), mRNA.	343					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CCTTGTTTCTCAAAGAGTACA	0.463000													19	133					0	0	1	0	0
ZNF417	147687	broad.mit.edu	37	19	58423500	58423500	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:58423500G>C	uc002qqq.3	-	1	290	c.91C>G	c.(91-93)Ctt>Gtt	p.L31V	ZNF417_uc010yhm.2_5'UTR|ZNF417_uc002qqr.3_Missense_Mutation_p.L30V	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	Homo sapiens zinc finger protein 417 (ZNF417), mRNA.	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TCACTAAGAAGACACCACTCC	0.507000													9	212					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118572	118572	+	RNA	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chrGL000205.1:118572G>A	uc002kgk.4	+	0		c.1950G>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GGCCTTTTTAGCTGATTCCGG	0.398000													14	73					0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66499795	66499795	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr9:66499795G>A	uc004aee.1	+	0	605	c.605G>A	c.(604-606)cGc>cAc	p.R202H	X97876_uc004aed.1_Non-coding_Transcript					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).																		TGCAAGTCGCGCAAGGAGCAG	0.592000													9	138					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71649963	71649963	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:71649963C>A	uc002shx.3	+	21	3642	c.3319C>A	c.(3319-3321)Cca>Aca	p.P1107T	ZNF638_uc010yqw.1_Missense_Mutation_p.P686T|ZNF638_uc002shz.3_Missense_Mutation_p.P1107T|ZNF638_uc002shy.3_Missense_Mutation_p.P1107T|ZNF638_uc002sia.3_Missense_Mutation_p.P1107T|ZNF638_uc002sib.1_Intron|ZNF638_uc002sic.3_Missense_Mutation_p.P204T|ZNF638_uc002sid.3_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	Homo sapiens zinc finger protein 638 (ZNF638), transcript variant 1, mRNA.	1107	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	RNA binding|double-stranded DNA binding|nucleotide binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GAAAAACAGTCCAATTGATGA	0.338000													4	124					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	107062359	107062359	+	RNA	SNP	G	G	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:107062359G>T	uc021ser.1	-	150		c.6627C>A								Parts of antibodies, mostly variable regions.																		AGACAGCGCAGATGAGGGACA	0.607000													6	137					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96762205	96762205	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr4:96762205C>T	uc003htr.4	+	0	967	c.904C>T	c.(904-906)Cga>Tga	p.R302*		NM_005390	NP_005381	P29803	ODPAT_HUMAN	Homo sapiens pyruvate dehydrogenase (lipoamide) alpha 2 (PDHA2), mRNA.	302					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TTATCGTACACGAGAAGAAAT	0.423000													15	136					0	0	1	0	0
ANKRD20A2	441430	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:95522772T>C	uc010fhp.3	-	0		c.49A>G						Q5SQ80	A20A2_HUMAN	Homo sapiens ankyrin repeat domain 20 family, member A8, pseudogene (ANKRD20A8P), non-coding RNA.									p.E49G(1)		large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	4						GCGCTCCACCTCCGCGGCGTC	0.682000													4	115					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6649154	6649154	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:6649154G>A	uc009vmc.2	+	10	2072	c.1949G>A	c.(1948-1950)gGc>gAc	p.G650D	ZBTB48_uc001anx.3_Missense_Mutation_p.G650D|ZBTB48_uc009vmd.2_Missense_Mutation_p.G650D|ZBTB48_uc001any.2_Missense_Mutation_p.G288D	NM_005341	NP_005332	P10074	ZBT48_HUMAN	Homo sapiens zinc finger and BTB domain containing 48 (ZBTB48), mRNA.	650						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GCCCAGGGCGGCCTGGCCTCC	0.672000													5	175					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	107062360	107062360	+	RNA	SNP	A	A	G			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:107062360A>G	uc021ser.1	-	150		c.6626T>C								Parts of antibodies, mostly variable regions.																		GACAGCGCAGATGAGGGACAG	0.612000													8	133					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51825914	51825914	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr13:51825914C>T	uc001vff.2	+	3	687	c.519C>T	c.(517-519)caC>caT	p.H173H	FAM124A_uc001vfe.3_Silent_p.H137H|FAM124A_uc001vfg.2_Silent_p.H137H	NM_145019	NP_659456	Q86V42	F124A_HUMAN	Homo sapiens family with sequence similarity 124A (FAM124A), transcript variant 1, mRNA.	137										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		AGCAGGTGCACGGCCGGTTCC	0.672000													4	16					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	RNA	SNP	C	C	T	rs75189823	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593025C>T	uc010yug.1	-	26		c.1888G>A			ANKRD36C_uc002sva.1_Non-coding_Transcript|ANKRD36C_uc002svc.1_Non-coding_Transcript					Homo sapiens cDNA FLJ54441 complete cds, highly similar to Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	100					0	0	1	0	0
AK302879	0	broad.mit.edu	37	15	76074470	76074470	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr15:76074470A>G	uc010umm.1	+	7	649	c.572A>G	c.(571-573)cAg>cGg	p.Q191R	DNM1P35_uc021sqp.1_Intron|DQ582939_uc002bba.1_5'Flank					SubName: Full=cDNA FLJ59077, highly similar to Golgin subfamily A member 6;									p.Q203R(4)									CGGTTACAGCAGACCATAAAG	0.577000													4	19					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645337	45645337	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:45645337G>A	uc003jok.3	-	1	824	c.799C>T	c.(799-801)Cgt>Tgt	p.R267C		NM_021072	NP_066550	O60741	HCN1_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1), mRNA.	267						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.R267L(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CGTAATAAACGCAAGAGACTG	0.313000													7	52					0	0	1	0	0
LRRC27	80313	broad.mit.edu	37	10	134158049	134158049	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr10:134158049G>T	uc010quw.1	+	4	643	c.448G>T	c.(448-450)Gaa>Taa	p.E150*	LRRC27_uc001llf.2_Nonsense_Mutation_p.E150*|LRRC27_uc010quv.1_Nonsense_Mutation_p.E150*|LRRC27_uc001llg.2_Non-coding_Transcript|LRRC27_uc001lli.2_Nonsense_Mutation_p.E150*|LRRC27_uc001llj.2_Nonsense_Mutation_p.E88*|LRRC27_uc001llk.4_Nonsense_Mutation_p.E23*	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	Homo sapiens leucine rich repeat containing 27 (LRRC27), transcript variant 1, mRNA.	150										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	18		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CTGCCCTCTGGAATTCCCTCC	0.498000													12	189					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr9:20414346G>A	uc003zoe.2	-	4	757	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_uc011lne.1_Silent_p.S134S|MLLT3_uc011lnf.1_Silent_p.S163S|MLLT3_uc003zof.3_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mRNA.	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(8)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	113					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9243051	9243051	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr12:9243051C>T	uc001qvk.1	-	19	2610	c.2497G>A	c.(2497-2499)Gcc>Acc	p.A833T	A2M_uc009zgk.1_Missense_Mutation_p.A683T	NM_000014	NP_000005	P01023	A2MG_HUMAN	Homo sapiens alpha-2-macroglobulin (A2M), mRNA.	833					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	GTPase activator activity|enzyme binding|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTAGGAAGGCGGGAGAGGCT	0.532000													12	137					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38958369	38958369	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:38958369C>T	uc002oit.3	+	24	3428	c.3298C>T	c.(3298-3300)Cgc>Tgc	p.R1100C	RYR1_uc002oiu.3_Missense_Mutation_p.R1100C	NM_000540	NP_000531	P21817	RYR1_HUMAN	Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 1, mRNA.	1100	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	I band|cell cortex|cytosol|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGCGAGATGCGCGTGGGCTG	0.622000													5	191					0	0	1	0	0
SAMD1	90378	broad.mit.edu	37	19	14199510	14199510	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:14199510C>T	uc010xnl.2	-	4	1113	c.1113G>A	c.(1111-1113)ccG>ccA	p.P371P		NM_138352	NP_612361	Q6SPF0	SAMD1_HUMAN	Homo sapiens sterile alpha motif domain containing 1 (SAMD1), mRNA.	477						cytoplasm|extracellular region				endometrium(3)	3		Renal(1328;0.00183)|Hepatocellular(1079;0.00826)		GBM - Glioblastoma multiforme(1328;0.000411)|STAD - Stomach adenocarcinoma(1328;0.00644)|Lung(535;0.199)		TCGCCTGCTCCGGGAATCCAG	0.567000													4	89					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758619	5758619	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:5758619delC	uc001mbt.2	+	0	942	c.873delC	c.(871-873)atcfs	p.I291fs	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.2_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	Homo sapiens olfactory receptor, family 56, subfamily B, member 1 (OR56B1), mRNA.	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ACAACATCATCCCCCCTTCCC	0.403													7	585	---	---	---	---					
ANKRD20A9P	284232	broad.mit.edu	37	13	19420047	19420053	+	RNA	DEL	TTCGTAT	TTCGTAT	-	rs117180361	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr13:19420047_19420053delTTCGTAT	uc010tcj.1	-	0		c.26057_26063delATACGAA								Homo sapiens ankyrin repeat domain 20 family, member A9, pseudogene (ANKRD20A9P), non-coding RNA.																		ATAACATTTCTTCGTATTTTATATTTT	0.246													7	34	---	---	---	---					
FOXN3	1112	broad.mit.edu	37	14	89629149	89629151	+	In_Frame_Del	DEL	GAG	GAG	-	rs139532153		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:89629149_89629151delGAG	uc001xxo.4	-	6	1217_1219	c.1080_1082delCTC	c.(1078-1083)tcctca>tca	p.360_361SS>S	FOXN3_uc001xxn.4_In_Frame_Del_p.338_339SS>S|FOXN3_uc010atk.3_In_Frame_Del_p.338_339SS>S	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	Homo sapiens forkhead box N3 (FOXN3), transcript variant 1, mRNA.	360					DNA damage checkpoint|G2 phase of mitotic cell cycle|embryo development|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCGTCGGCTGAGGAGGAGGAGG	0.650													7	84	---	---	---	---					
MT4	84560	broad.mit.edu	37	16	56602769	56602769	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr16:56602769delC	uc002eje.1	+	2	194	c.114delC	c.(112-114)tgcfs	p.C38fs		NM_032935	NP_116324	P47944	MT4_HUMAN	Homo sapiens metallothionein 4 (MT4), mRNA.	38						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						GTCCCTGCTGCCCCCCGGGCT	0.597													8	485	---	---	---	---					
ANKRD24	170961	broad.mit.edu	37	19	4217746	4217746	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:4217746delG	uc010dtt.1	+	17	2865	c.2589delG	c.(2587-2589)acgfs	p.T863fs	ANKRD24_uc002lzs.2_Frame_Shift_Del_p.T834fs|ANKRD24_uc002lzt.2_Frame_Shift_Del_p.T835fs	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	Homo sapiens ankyrin repeat domain 24 (ANKRD24), mRNA.	863										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CCAGGGCCACGGGGGAGCAGC	0.791													2	4	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628310	29628312	+	In_Frame_Del	DEL	AGG	AGG	-	rs111939959		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:29628310_29628312delAGG	uc010ztl.1	+	2	254_256	c.222_224delAGG	c.(220-225)gcagga>gca	p.G75del	FRG1B_uc002wvm.1_Non-coding_Transcript|FRG1B_uc010ztj.1_Non-coding_Transcript|FRG1B_uc010gdr.1_Non-coding_Transcript|FRG1B_uc010ztk.1_In_Frame_Del_p.G27del					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.											endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTAAAACAGCAGGAGAAGAAGAA	0.355													7	218	---	---	---	---					
