Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EPB41L3	23136	broad.mit.edu	37	18	5423443	5423443	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr18:5423443G>A	uc002kmt.1	-	10	1359	c.1273C>T	c.(1273-1275)Cgc>Tgc	p.R425C	EPB41L3_uc010wzh.1_Missense_Mutation_p.R425C|EPB41L3_uc002kmu.1_Missense_Mutation_p.R425C|EPB41L3_uc010dkq.1_Missense_Mutation_p.R316C|EPB41L3_uc010dkr.2_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	Homo sapiens erythrocyte membrane protein band 4.1-like 3 (EPB41L3), mRNA.	425	Hydrophilic.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GGTGCTGGGCGATCTATCAAC	0.493000													12	49					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30963507	30963507	+	Silent	SNP	C	C	T	rs144528849		TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr21:30963507C>T	uc002yno.1	-	9	1754	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	GRIK1_uc002ynn.3_Silent_p.T415T|GRIK1_uc011acs.2_Silent_p.T430T|GRIK1_uc011act.2_Silent_p.T359T|GRIK1_uc010glq.1_Silent_p.T273T	NM_000830	NP_000821	P39086	GRIK1_HUMAN	Homo sapiens glutamate receptor, ionotropic, kainate 1 (GRIK1), transcript variant 1, mRNA.	430					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity	p.T430T(1)|p.T415T(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TGTTGCTGTCCGTCATGTTAA	0.448000													6	175					0	0	1	0	0
LOC283788	283788	broad.mit.edu	37	GL000219.1	88318	88318	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chrGL000219.1:88318G>A	uc022brb.1	-	2	326	c.13C>T	c.(13-15)Ccc>Tcc	p.P5S	LOC283788_uc011mfq.2_Non-coding_Transcript					Homo sapiens FSHD region gene 1 pseudogene (LOC283788), non-coding RNA.																		AGCTCCCAGGGTAAAAAGACC	0.413000													7	151					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134079319	134079319	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr11:134079319C>T	uc001qhd.1	-	4	1226	c.620G>A	c.(619-621)cGg>cAg	p.R207Q	NCAPD3_uc010scm.1_Non-coding_Transcript|NCAPD3_uc009zda.1_Non-coding_Transcript	NM_015261	NP_056076	P42695	CNDD3_HUMAN	Homo sapiens non-SMC condensin II complex, subunit D3 (NCAPD3), mRNA.	207					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		AGAAAGGTCCCGGGCAGAAAA	0.343000													4	56					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30715429	30715429	+	Silent	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr16:30715429C>T	uc002dze.1	+	3	484	c.99C>T	c.(97-99)gcC>gcT	p.A33A	SRCAP_uc021tgn.1_Silent_p.A33A|SRCAP_uc002dzf.3_Non-coding_Transcript	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA.	33					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGTCCCCTGCCTCATCCAGTT	0.552000													31	108					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63526188	63526188	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr17:63526188G>A	uc002jfi.3	-	10	2727	c.2438C>T	c.(2437-2439)gCc>gTc	p.A813V	AXIN2_uc002jfh.3_Missense_Mutation_p.A748V	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	Homo sapiens axin 2 (AXIN2), mRNA.	813	DIX.				Wnt receptor signaling pathway involved in somitogenesis|cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|mRNA stabilization|maintenance of DNA repeat elements|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	GTPase activator activity|armadillo repeat domain binding|beta-catenin binding|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						CGCTCCACAGGCAAACTCATC	0.453000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				4	128					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58126185	58126185	+	Missense_Mutation	SNP	G	G	A	rs142474037		TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr11:58126185G>A	uc010rke.2	-	0	358	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily B, member 17 (OR5B17), mRNA.	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R120C(2)		NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCTGCGTAGCGGTCATAGGCC	0.473000													4	84					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107976000	107976000	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chrX:107976000G>A	uc004eoc.2	-	0	3608	c.3575C>T	c.(3574-3576)cCa>cTa	p.P1192L		NM_003604	NP_003595	O14654	IRS4_HUMAN	Homo sapiens insulin receptor substrate 4 (IRS4), mRNA.	1192	Ala-rich.					plasma membrane	SH3/SH2 adaptor activity|insulin receptor binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GTTTGCAGATGGGTTGTGGGC	0.637000													6	130					0	0	1	0	0
RGS16	6004	broad.mit.edu	37	1	182571581	182571581	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr1:182571581G>C	uc001gpl.4	-	2	348	c.194C>G	c.(193-195)tCg>tGg	p.S65W	RGS16_uc010pnv.1_Missense_Mutation_p.S65W	NM_002928	NP_002919	O15492	RGS16_HUMAN	Homo sapiens regulator of G-protein signaling 16 (RGS16), mRNA.	65	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	GTPase activator activity|calmodulin binding|signal transducer activity			NS(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)	11						CAGGTCGAACGACTCTCTCCA	0.438000													11	54					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001362	109001362	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr8:109001362G>A	uc003yms.3	-	2	863	c.205C>T	c.(205-207)Cgc>Tgc	p.R69C	RSPO2_uc003ymq.3_Missense_Mutation_p.R2C|RSPO2_uc003ymr.3_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	Homo sapiens R-spondin 2 (RSPO2), mRNA.	69					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CCATACTGGCGCATCCCTTCT	0.473000													15	66					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002491	69002491	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr2:69002491A>G	uc010fdg.3	+	1	619	c.200A>G	c.(199-201)tAc>tGc	p.Y67C	ARHGAP25_uc010yqk.2_Missense_Mutation_p.Y41C|ARHGAP25_uc010yql.2_Missense_Mutation_p.Y67C|ARHGAP25_uc002sev.3_Missense_Mutation_p.Y60C|ARHGAP25_uc002sew.3_Missense_Mutation_p.Y60C|ARHGAP25_uc002sex.3_Missense_Mutation_p.Y60C|ARHGAP25_uc010fdh.1_Intron	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Homo sapiens Rho GTPase activating protein 25 (ARHGAP25), transcript variant 1, mRNA.	67	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CAGCAGAGGTACTTTGTGCTG	0.577000													7	223					0	0	1	0	0
KIRREL	55243	broad.mit.edu	37	1	158059381	158059381	+	Silent	SNP	C	C	T	rs146308217	byFrequency	TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr1:158059381C>T	uc001frn.4	+	8	1538	c.1134C>T	c.(1132-1134)atC>atT	p.I378I	KIRREL_uc010pib.2_Silent_p.I278I|KIRREL_uc009wsq.3_Silent_p.I214I|KIRREL_uc001fro.4_Silent_p.I192I	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	Homo sapiens kin of IRRE like (Drosophila) (KIRREL), mRNA.	378	Ig-like C2-type 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					TGCCTCGAATCGGAGTGGCTG	0.622000													18	96					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62173140	62173140	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr15:62173140G>T	uc002agz.3	-	71	9881	c.9790C>A	c.(9790-9792)Ctc>Atc	p.L3264I	VPS13C_uc002aha.3_Missense_Mutation_p.L3221I|VPS13C_uc002ahb.2_Missense_Mutation_p.L3264I|VPS13C_uc002ahc.2_Missense_Mutation_p.L3221I	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	Homo sapiens vacuolar protein sorting 13 homolog C (S. cerevisiae) (VPS13C), transcript variant 2A, mRNA.	3264					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TCCTGAATGAGGACCATAAAA	0.338000													3	54					0	0	1	0	0
ERMAP	114625	broad.mit.edu	37	1	43296726	43296726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr1:43296726C>T	uc001cic.1	+	3	643	c.373C>T	c.(373-375)Cga>Tga	p.R125*	ERMAP_uc010ojw.1_Nonsense_Mutation_p.R186*|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Nonsense_Mutation_p.R125*|ERMAP_uc001cif.1_Nonsense_Mutation_p.R35*	NM_001017922	NP_061008	Q96PL5	ERMAP_HUMAN	Homo sapiens erythroblast membrane-associated protein (Scianna blood group) (ERMAP), transcript variant 1, mRNA.	125	Ig-like V-type.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGGTCTTACCGATGTCTGAT	0.527000													9	48					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41622408	41622408	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr19:41622408C>T	uc002opu.1	+	2	276	c.220C>T	c.(220-222)Cgg>Tgg	p.R74W	CYP2F1_uc021uuv.1_5'UTR|CYP2F1_uc010xvv.1_Missense_Mutation_p.R74W|CYP2F1_uc002opv.1_Non-coding_Transcript	NM_000774	NP_000765	P24903	CP2F1_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily F, polypeptide 1 (CYP2F1), mRNA.	74					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						GGGACCCAGGCGGGTGGTGGT	0.602000													23	178					0	0	1	0	0
NARS2	79731	broad.mit.edu	37	11	78277282	78277282	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr11:78277282C>A	uc001ozi.3	-	3	785	c.409G>T	c.(409-411)Gag>Tag	p.E137*	NARS2_uc010rsq.2_5'UTR	NM_024678	NP_001230180	Q96I59	SYNM_HUMAN	Homo sapiens asparaginyl-tRNA synthetase 2, mitochondrial (putative) (NARS2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	137					asparaginyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|asparagine-tRNA ligase activity|nucleic acid binding	p.E137D(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CGCAGATACTCCAGAGGATGC	0.373000													5	82					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38165192	38165192	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr22:38165192C>T	uc003atr.3	+	19	7004	c.6733C>T	c.(6733-6735)Cag>Tag	p.Q2245*	TRIOBP_uc003atu.3_Nonsense_Mutation_p.Q2073*|TRIOBP_uc003atw.3_Nonsense_Mutation_p.Q532*|TRIOBP_uc003atx.1_Nonsense_Mutation_p.Q128*|TRIOBP_uc010gxh.3_Nonsense_Mutation_p.Q128*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	Homo sapiens TRIO and F-actin binding protein (TRIOBP), transcript variant 6, mRNA.	2245					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	GTP-Rho binding|actin binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCGCCACAACCAGGTGGGCCT	0.711000													7	14					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73544680	73544680	+	Silent	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr10:73544680C>T	uc001jrx.4	+	40	5916	c.5526C>T	c.(5524-5526)aaC>aaT	p.N1842N		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	Homo sapiens cadherin-related 23 (CDH23), transcript variant 1, mRNA.	1845	Cadherin 17.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						TGGACATCAACGACAACGACC	0.597000													20	43					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21240178	21240178	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr19:21240178A>G	uc002npj.3	+	4	1245	c.1064A>G	c.(1063-1065)aAc>aGc	p.N355S	ZNF430_uc002npk.3_Missense_Mutation_p.N354S	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	Homo sapiens zinc finger protein 430 (ZNF430), transcript variant 1, mRNA.	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.N355S(2)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						AAAGCTTTTAACCAATCCTCA	0.388000													4	90					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167217986	167217986	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr3:167217986C>A	uc003fev.1	-	13	2234	c.1930G>T	c.(1930-1932)Gag>Tag	p.E644*	WDR49_uc003feu.1_Nonsense_Mutation_p.E469*|WDR49_uc011bpd.1_Nonsense_Mutation_p.E609*|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	Homo sapiens WD repeat domain 49 (WDR49), mRNA.	644										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CGCTCTTCCTCTGGTTCTTTC	0.428000													47	206					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21240182	21240182	+	Silent	SNP	A	A	G			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr19:21240182A>G	uc002npj.3	+	4	1249	c.1068A>G	c.(1066-1068)caA>caG	p.Q356Q	ZNF430_uc002npk.3_Silent_p.Q355Q	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	Homo sapiens zinc finger protein 430 (ZNF430), transcript variant 1, mRNA.	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q356Q(2)|p.N355S(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						CTTTTAACCAATCCTCAACCC	0.383000													4	88					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90904247	90904247	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr15:90904247G>A	uc002bpk.4	+	3	1370	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	Homo sapiens zinc finger protein 774 (ZNF774), mRNA.	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAGCACCAACGAATCCACACC	0.498000													27	79					0	0	1	0	0
SPINK9	643394	broad.mit.edu	37	5	147718067	147718067	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr5:147718067A>C	uc003lpe.1	+	2	169	c.114A>C	c.(112-114)ttA>ttC	p.L38F	AK054753_uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	Homo sapiens serine peptidase inhibitor, Kazal type 9 (SPINK9), mRNA.	38	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|urinary_tract(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAAAAAGTTACCACCAGGAC	0.308000													14	33					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84075582	84075582	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr16:84075582C>T	uc002fhg.1	-	0	181	c.181G>A	c.(181-183)Gtg>Atg	p.V61M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	Homo sapiens solute carrier family 38, member 8 (SLC38A8), mRNA.	61					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						ACCAGCTCCACCAGGAAGGCA	0.632000													33	119					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220402012	220402012	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr2:220402012C>T	uc002vlz.3	+	7	1925	c.1751C>T	c.(1750-1752)aCg>aTg	p.T584M	ASIC4_uc002vma.3_Missense_Mutation_p.T565M|ASIC4_uc002vmb.3_Missense_Mutation_p.T238M	NM_018674	NP_061144	Q96FT7	ACCN4_HUMAN	Homo sapiens amiloride-sensitive cation channel 4, pituitary (ACCN4), transcript variant 1, mRNA.	565						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										AGCATCCTCACGTTGCTGGAG	0.657000													9	30					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38938515	38938515	+	Silent	SNP	G	G	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr17:38938515G>A	uc002hvg.3	-	0	272	c.231C>T	c.(229-231)caC>caT	p.H77H		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	Homo sapiens keratin 27 (KRT27), mRNA.	77	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity	p.E76*(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				AGAGGAGGCCGTGCTCATTCC	0.597000													31	93					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10561280	10561280	+	Splice_Site	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr19:10561280C>T	uc002moj.2	+	5	729	c.621_splice	c.e5-1	p.K207_splice	PDE4A_uc021uow.1_Splice_Site_p.K185_splice|PDE4A_uc002mok.2_Splice_Site_p.K181_splice|PDE4A_uc002mol.2_Splice_Site_p.K146_splice|PDE4A_uc002mom.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 1, mRNA.	207					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TTTCTGCAGGCGGTCCCCGCT	0.627000													6	15					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359169	145359169	+	Missense_Mutation	SNP	T	T	A			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr1:145359169T>A	uc021oul.1	+	71	9144	c.9109T>A	c.(9109-9111)Ttg>Atg	p.L3037M	NBPF10_uc010oye.2_Intron|NBPF10_uc010oyi.2_Intron|NBPF10_uc010oyj.2_Intron|NBPF10_uc010oyl.2_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc021ouq.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 10 (NBPF10), mRNA.	3037								p.L3037M(14)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCGTGTTGGCTTGGCTGTTGA	0.458000													6	344					0	0	1	0	0
CYP2W1	54905	broad.mit.edu	37	7	1026363	1026363	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr7:1026363C>T	uc003sjq.1	+	4	762	c.749C>T	c.(748-750)gCg>gTg	p.A250V	CYP2W1_uc003sjr.1_Missense_Mutation_p.A250V	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily W, polypeptide 1 (CYP2W1), mRNA.	250					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CTCCTGGAGGCGCGGAGGCCC	0.672000													10	21					0	0	1	0	0
STAG3L2	442582	broad.mit.edu	37	7	74300557	74300564	+	Frame_Shift_Del	DEL	AGAGCTCC	AGAGCTCC	-			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr7:74300557_74300564delAGAGCTCC	uc022afy.1	-	2	316_323	c.243_250delGGAGCTCT	c.(241-252)ctggagctcttcfs	p.L81fs	STAG3L2_uc011kfj.2_Non-coding_Transcript|STAG3L2_uc022afz.1_Non-coding_Transcript			P0CL84	ST3L2_HUMAN	Homo sapiens stromal antigen 3-like 2 (STAG3L2), non-coding RNA.	81	SCD.					nucleus	binding	p.E82fs*32(4)|p.R80C(1)		breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CGGCCAGTGAAGAGCTCCAGGCGTGCGG	0.572													3	4	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr7:131241030_131241035delGGCGAC	uc003vqw.4	-	0	342_347	c.84_89delGTCGCC	c.(82-90)ccgtcgccc>ccc	p.28_30PSP>P	PODXL_uc003vqx.4_In_Frame_Del_p.28_30PSP>P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	Homo sapiens podocalyxin-like (PODXL), transcript variant 1, mRNA.	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(4)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													7	7	---	---	---	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-J4-A67S-01A-11D-A30E-08	TCGA-J4-A67S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f76caec-6872-4f66-a84d-5c31c5cc24c5	b384da3b-69cc-4f3a-a804-090440fa25f6	g.chr18:34261459_34261460delAG	uc021uiv.1	+	14	1993_1994	c.1896_1897delAG	c.(1894-1899)gcagagfs	p.A632fs	FHOD3_uc002kzr.1_Frame_Shift_Del_p.A457fs|FHOD3_uc002kzs.1_Frame_Shift_Del_p.A457fs|FHOD3_uc002kzt.1_Frame_Shift_Del_p.A457fs|FHOD3_uc010dmz.1_Frame_Shift_Del_p.A172fs	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	Homo sapiens formin homology 2 domain containing 3 (FHOD3), mRNA.	457	Poly-Ser.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													7	114	---	---	---	---					
