Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr2:107049631C>T	uc010ywi.1	-	15	2373	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	Homo sapiens RANBP2-like and GRIP domain containing 3 (RGPD3), mRNA.	772					intracellular transport		binding	p.A772A(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													5	198					0	0	1	0	0
ZNF738	148203	broad.mit.edu	37	19	21558687	21558687	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:21558687G>A	uc002nps.4	+	3	448	c.240G>A	c.(238-240)aaG>aaA	p.K80K	ZNF738_uc002npt.3_Non-coding_Transcript					Homo sapiens zinc finger protein 738 (ZNF738), non-coding RNA.											kidney(1)|lung(1)	2						ATGTCTCTAAGCCAGATCTGA	0.388000													19	47					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844290	128844290	+	Silent	SNP	T	T	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr11:128844290T>C	uc009zcp.3	-	19	2760	c.2760A>G	c.(2758-2760)tcA>tcG	p.S920S	ARHGAP32_uc009zcq.2_Silent_p.S880S|ARHGAP32_uc009zco.3_5'UTR|ARHGAP32_uc001qez.3_Silent_p.S571S	NM_001142685	NP_055530	A7KAX9	RHG32_HUMAN	Homo sapiens Rho GTPase activating protein 32 (ARHGAP32), transcript variant 1, mRNA.	920					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	Golgi membrane|cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CAATGACTTCTGACACCCGTG	0.453000													13	76					0	0	1	0	0
WDR82	80335	broad.mit.edu	37	3	52304795	52304795	+	Silent	SNP	A	A	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr3:52304795A>G	uc003ddl.2	-	1	474	c.192T>C	c.(190-192)taT>taC	p.Y64Y	WDR82_uc003ddk.2_5'Flank|MIRLET7G_uc011bee.2_5'Flank	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	Homo sapiens WD repeat domain 82 (WDR82), mRNA.	64					histone H3-K4 methylation	PTW/PP1 phosphatase complex|Set1C/COMPASS complex|chromatin	protein binding								BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		GGTCCACACCATATTTCTTAC	0.383000													20	197					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1900969	1900969	+	Silent	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr8:1900969C>T	uc003wpr.3	+	27	3674	c.3496C>T	c.(3496-3498)Ctg>Ttg	p.L1166L	ARHGEF10_uc003wps.3_Silent_p.L1128L|ARHGEF10_uc010lre.3_Silent_p.L817L	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10 (ARHGEF10), mRNA.	1191					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	Rho guanyl-nucleotide exchange factor activity|kinesin binding			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GGTCCCACGTCTGCAAGGGAT	0.622000													39	13					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128186	152128186	+	Silent	SNP	A	A	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr1:152128186A>G	uc001ezs.1	-	2	1454	c.1389T>C	c.(1387-1389)taT>taC	p.Y463Y		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	Homo sapiens repetin (RPTN), mRNA.	463	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.H462N(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTCTGACCATAGTGGGAAC	0.512000													9	896					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5510455	5510455	+	Silent	SNP	T	T	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr11:5510455T>C	uc010qzg.2	+	0	541	c.519T>C	c.(517-519)ggT>ggC	p.G173G	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc021qcv.1_Intron|OR51B5_uc001maq.2_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	Homo sapiens olfactory receptor, family 52, subfamily D, member 1 (OR52D1), mRNA.	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTACTGTGGTCACCGTGTCA	0.512000													9	226					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228846444	228846444	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr2:228846444C>A	uc002vpq.2	-	11	5139	c.5092G>T	c.(5092-5094)Gaa>Taa	p.E1698*	SPHKAP_uc002vpp.2_Nonsense_Mutation_p.E1669*|SPHKAP_uc010zlx.1_3'UTR	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	Homo sapiens SPHK1 interactor, AKAP domain containing (SPHKAP), transcript variant 1, mRNA.	1698						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TATCCCAGTTCCAAGAGCCAG	0.428000													7	73					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111618107	111618107	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:111618107G>A	uc004bdi.3	-	0	169	c.104C>T	c.(103-105)gCg>gTg	p.A35V		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	Homo sapiens actin-like 7B (ACTL7B), mRNA.	35						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CTGAGTGGCCGCACCTGTGTC	0.657000													5	136					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52960700	52960700	+	Missense_Mutation	SNP	G	G	A	rs143324533		TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr4:52960700G>A	uc003gzl.3	+	11	1849	c.1571G>A	c.(1570-1572)cGa>cAa	p.R524Q	SPATA18_uc010igl.1_Non-coding_Transcript|SPATA18_uc011bzq.2_Missense_Mutation_p.R492Q	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	Homo sapiens spermatogenesis associated 18 (SPATA18), mRNA.	524					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CAGATGTCTCGAAGTCGGAGT	0.343000													5	53					0	0	1	0	0
GKN2	200504	broad.mit.edu	37	2	69173530	69173530	+	Silent	SNP	C	C	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr2:69173530C>G	uc002sfa.3	-	4	487	c.378G>C	c.(376-378)ctG>ctC	p.L126L	GKN2_uc002sfb.4_Silent_p.L126L	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	Homo sapiens gastrokine 2 (GKN2), mRNA.	126	BRICHOS.					extracellular region				autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	15						CGTCTTTGATCAGAGACTCCA	0.433000													82	102					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140809212	140809212	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:140809212G>A	uc004cog.3	+	4	874	c.729G>A	c.(727-729)gaG>gaA	p.E243E	CACNA1B_uc022bqn.1_Silent_p.E243E	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), transcript variant 1, mRNA.	243					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TTGGCCTGGAGTTCTACATGG	0.557000													6	26					0	0	1	0	0
C4orf51	646603	broad.mit.edu	37	4	146650335	146650335	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr4:146650335G>T	uc003ikk.3	+	3	381	c.381G>T	c.(379-381)tgG>tgT	p.W127C		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	Homo sapiens chromosome 4 open reading frame 51 (C4orf51), mRNA.	127										haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)	6						ATCAAATTTGGGATTTTGGTG	0.313000													5	7					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42989096	42989096	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr17:42989096C>A	uc021tyh.1	-	4	916	c.850G>T	c.(850-852)Gac>Tac	p.D284Y	GFAP_uc002ihq.3_Missense_Mutation_p.D284Y|GFAP_uc002ihr.3_Missense_Mutation_p.D284Y|GFAP_uc010wjg.2_Non-coding_Transcript	NM_001242376	NP_001229305	P14136	GFAP_HUMAN	Homo sapiens glial fibrillary acidic protein (GFAP), transcript variant 3, mRNA.	284	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				CGCCGGTAGTCGTTGGCTTCG	0.682000													39	53					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380363	56380363	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr11:56380363T>G	uc001nja.1	-	0	616	c.616A>C	c.(616-618)Aat>Cat	p.N206H	OR8U8_uc001nit.2_Intron	NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily M, member 1 (OR5M1), mRNA.	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						CTTGAGAGATTAAAGCCTGCA	0.443000													37	73					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540948	40540948	+	Silent	SNP	A	A	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:40540948A>G	uc002omu.3	-	4	1883	c.1818T>C	c.(1816-1818)ttT>ttC	p.F606F	ZNF780B_uc002omv.3_Silent_p.F458F	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	Homo sapiens zinc finger protein 780B (ZNF780B), mRNA.	606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CACCAGTATGAAATTTCTGAT	0.418000													9	129					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230198	38230198	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:38230198C>A	uc002ohe.3	-	4	1262	c.1193G>T	c.(1192-1194)gGt>gTt	p.G398V	ZNF573_uc010efs.2_Missense_Mutation_p.G311V|ZNF573_uc002ohd.3_Missense_Mutation_p.G396V|ZNF573_uc002ohf.3_Missense_Mutation_p.G340V|ZNF573_uc002ohg.3_Missense_Mutation_p.G310V|ZNF573_uc021utv.1_Missense_Mutation_p.G310V	NM_001172690	NP_001166161	Q86YE8	ZN573_HUMAN	Homo sapiens zinc finger protein 573 (ZNF573), transcript variant 3, mRNA.	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			GAGTTTTGAACCAGTAGTATA	0.378000													25	139					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100866042	100866042	+	Silent	SNP	A	A	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr8:100866042A>G	uc003yiv.3	+	55	10611	c.10500A>G	c.(10498-10500)aaA>aaG	p.K3500K	VPS13B_uc003yiw.3_Silent_p.K3475K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	Homo sapiens vacuolar protein sorting 13 homolog B (yeast) (VPS13B), transcript variant 5, mRNA.	3500					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACAAGGAAAAATGTTTTATCA	0.393000													5	273					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342280	60342280	+	RNA	SNP	C	C	T	rs80012429		TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr17:60342280C>T	uc010woz.2	-	13		c.1849G>A								Homo sapiens TBC1 domain family, member 3 pseudogene 2 (TBC1D3P2), non-coding RNA.											breast(2)|kidney(1)|lung(2)	5						TTAATACATTCTCATAAGTTT	0.488000													8	107					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155147951	155147951	+	Silent	SNP	C	C	T	rs149212033		TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr1:155147951C>T	uc001fhs.1	+	1	236	c.153C>T	c.(151-153)aaC>aaT	p.N51N	KRTCAP2_uc001fho.3_5'Flank|KRTCAP2_uc001fhp.1_5'Flank|TRIM46_uc009wpe.1_Non-coding_Transcript|TRIM46_uc010pez.1_Silent_p.N38N|TRIM46_uc001fhq.3_Non-coding_Transcript|TRIM46_uc001fhr.3_Silent_p.N51N|TRIM46_uc001fht.1_Non-coding_Transcript|TRIM46_uc010pfa.1_Intron|TRIM46_uc001fhu.1_Silent_p.N28N|TRIM46_uc009wpg.1_Silent_p.N38N|TRIM46_uc009wpf.2_Silent_p.N38N|TRIM46_uc001fhw.1_Non-coding_Transcript	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	Homo sapiens tripartite motif containing 46 (TRIM46), mRNA.	51						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTACCCACAACGTGTGCCAGG	0.607000													13	169					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111761374	111761374	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:111761374T>C	uc004bdo.1	-	1	346	c.304A>G	c.(304-306)Att>Gtt	p.I102V	CTNNAL1_uc004bdp.1_Missense_Mutation_p.I102V	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	Homo sapiens catenin (cadherin-associated protein), alpha-like 1 (CTNNAL1), mRNA.	102					Rho protein signal transduction|cell adhesion	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		ATACAAGCAATATTTATTTCT	0.338000													42	53					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41277810	41277810	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr22:41277810C>T	uc003azh.3	+	2	319	c.218C>T	c.(217-219)gCa>gTa	p.A73V	XPNPEP3_uc011aox.2_Missense_Mutation_p.A73V|XPNPEP3_uc003azi.3_5'UTR|XPNPEP3_uc011aoy.1_Non-coding_Transcript|XPNPEP3_uc010gyh.1_Non-coding_Transcript	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	Homo sapiens X-prolyl aminopeptidase (aminopeptidase P) 3, putative (XPNPEP3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	73					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						GTGGAATATGCACTTCGCAGA	0.453000													4	82					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46294679	46294679	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr20:46294679G>A	uc002xto.3	-	12	2154	c.1824C>T	c.(1822-1824)aaC>aaT	p.N608N	SULF2_uc002xtr.3_Silent_p.N608N|SULF2_uc002xtq.3_Silent_p.N608N|SULF2_uc010zyd.2_5'Flank	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	Homo sapiens sulfatase 2 (SULF2), transcript variant 1, mRNA.	608					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	Golgi stack|cell surface|endoplasmic reticulum|extracellular space	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						GGACTGTGTCGTTCTCTAGGA	0.602000													9	86					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140237684	140237684	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr5:140237684G>A	uc003lhx.2	+	0	2051	c.2051G>A	c.(2050-2052)gGc>gAc	p.G684D	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc011dad.2_Missense_Mutation_p.G684D	NM_018901	NP_061724	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 10 (PCDHA10), transcript variant 1, mRNA.	694	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTCAGTGGGCGTGGCGCCC	0.657000													23	48					0	0	1	0	0
FAM55C	91775	broad.mit.edu	37	3	101535763	101535763	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr3:101535763G>A	uc003dvn.3	+	6	1684	c.1047G>A	c.(1045-1047)gaG>gaA	p.E349E	FAM55C_uc010hpn.3_Silent_p.E349E	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	Homo sapiens family with sequence similarity 55, member C (FAM55C), transcript variant 2, mRNA.	349						extracellular region				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	32						ACATTACAGAGTGCTTACAAA	0.398000													14	213					0	0	1	0	0
CDK10	8558	broad.mit.edu	37	16	89760586	89760586	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr16:89760586G>A	uc010cio.3	+	8	657	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	CDK10_uc010cip.2_3'UTR|CDK10_uc010vpl.1_3'UTR|CDK10_uc002fob.2_Missense_Mutation_p.E111K|CDK10_uc002fod.3_Missense_Mutation_p.R134Q|CDK10_uc002foe.3_Missense_Mutation_p.R134Q|CDK10_uc002fof.3_Missense_Mutation_p.R134Q|CDK10_uc002fog.4_Missense_Mutation_p.R134Q|CDK10_uc002foh.4_Missense_Mutation_p.R134Q|CDK10_uc002foi.3_5'Flank	NM_052988	NP_001153839	Q15131	CDK10_HUMAN	Homo sapiens cyclin-dependent kinase 10 (CDK10), transcript variant a, mRNA.	205	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		TGTAGGTACCGAGCCCCTGAA	0.637000													3	24					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40323995	40323995	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr17:40323995G>A	uc002hzb.2	-	6	1339	c.1006C>T	c.(1006-1008)Ctg>Ttg	p.L336L		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 4 (KCNH4), mRNA.	336					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		aCTGTCTTCAGTAGGTGCACC	0.647000													4	18					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29856426	29856426	+	Missense_Mutation	SNP	C	C	G	rs116604310	by1000genomes	TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr6:29856426C>G	uc010jro.3	+	2	678	c.532C>G	c.(532-534)Cgg>Ggg	p.R178G	HLA-G_uc021ytw.1_Non-coding_Transcript|HLA-G_uc011dmb.2_Intron|HLA-J_uc021yty.1_5'Flank|HLA-G_uc021ytv.1_Missense_Mutation_p.R176G|HLA-J_uc021ytx.1_5'Flank			P17693	HLAG_HUMAN	Homo sapiens major histocompatibility complex, class I, H (pseudogene) (HLA-H), non-coding RNA.	176	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GGCGGCCCGTCGGGCGGAGCA	0.667000													3	25					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	231931019	231931019	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr1:231931019T>C	uc010pxh.2	+	7	1815	c.1762T>C	c.(1762-1764)Tca>Cca	p.S588P	DISC1_uc010pwj.1_Missense_Mutation_p.S545P|DISC1_uc010pwk.1_Missense_Mutation_p.S545P|DISC1_uc010pwg.1_Missense_Mutation_p.S545P|DISC1_uc010pwh.1_Missense_Mutation_p.S511P|DISC1_uc010pwi.1_Missense_Mutation_p.S511P|DISC1_uc010pwl.2_Intron|DISC1_uc010pwr.1_Missense_Mutation_p.S556P|DISC1_uc010pws.1_Missense_Mutation_p.S556P|DISC1_uc010pwt.1_Intron|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.2_Non-coding_Transcript|DISC1_uc010pwx.2_Non-coding_Transcript|DISC1_uc010pww.2_Missense_Mutation_p.S556P|DISC1_uc001huy.3_Missense_Mutation_p.S556P|DISC1_uc010pwy.2_Non-coding_Transcript|DISC1_uc010pwz.2_Non-coding_Transcript|DISC1_uc010pxa.2_Non-coding_Transcript|DISC1_uc010pxb.1_Missense_Mutation_p.S556P|DISC1_uc010pxc.1_Intron|DISC1_uc010pxe.2_Missense_Mutation_p.S556P|DISC1_uc010pxf.2_Missense_Mutation_p.S556P|DISC1_uc010pxg.2_Intron|DISC1_uc010pxd.2_Missense_Mutation_p.S201P|DISC1_uc009xfr.3_Missense_Mutation_p.S511P|DISC1_uc010pxn.1_Missense_Mutation_p.S201P|DISC1_uc010pxk.1_Non-coding_Transcript|DISC1_uc010pxi.1_Non-coding_Transcript|DISC1_uc010pxj.1_Missense_Mutation_p.S201P|DISC1_uc010pxl.1_Intron|DISC1_uc010pxm.2_Missense_Mutation_p.S434P|DISC1_uc001huz.3_Missense_Mutation_p.S556P|DISC1_uc001hva.3_Missense_Mutation_p.S556P	NM_001164537	NP_001158009	Q9NRI5	DISC1_HUMAN	Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant a, mRNA.	556	Interaction with TRAF3IP1.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Required for localization to punctate cytoplasmic foci.				Wnt receptor signaling pathway|microtubule cytoskeleton organization|neuron migration|positive regulation of Wnt receptor signaling pathway|positive regulation of neuroblast proliferation	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				CCTCAACTTGTCACTTAAAGA	0.348000													6	46					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29856427	29856427	+	Missense_Mutation	SNP	G	G	T	rs112476351	by1000genomes	TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr6:29856427G>T	uc010jro.3	+	2	679	c.533G>T	c.(532-534)cGg>cTg	p.R178L	HLA-G_uc021ytw.1_Non-coding_Transcript|HLA-G_uc011dmb.2_Intron|HLA-J_uc021yty.1_5'Flank|HLA-G_uc021ytv.1_Missense_Mutation_p.R176L|HLA-J_uc021ytx.1_5'Flank			P17693	HLAG_HUMAN	Homo sapiens major histocompatibility complex, class I, H (pseudogene) (HLA-H), non-coding RNA.	176	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GCGGCCCGTCGGGCGGAGCAG	0.667000													3	26					0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51457368	51457368	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr3:51457368C>T	uc003dbe.2	-	13	3082	c.2897G>A	c.(2896-2898)tGc>tAc	p.C966Y	VPRBP_uc021wys.1_Missense_Mutation_p.C965Y|VPRBP_uc003dbf.1_Missense_Mutation_p.C295Y	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	Homo sapiens Vpr (HIV-1) binding protein (VPRBP), transcript variant 1, mRNA.	1019					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TGGATTCTTGCAGCGAGCATG	0.488000													5	164					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088367	94088367	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr14:94088367G>A	uc001ybv.1	+	27	4406	c.4323G>A	c.(4321-4323)ccG>ccA	p.P1441P	UNC79_uc001ybs.1_Silent_p.P1419P	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	Homo sapiens unc-79 homolog (C. elegans) (UNC79), mRNA.	1596						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TTGACTCGCCGGTAAAGCCTG	0.478000													4	127					0	0	1	0	0
HPS3	84343	broad.mit.edu	37	3	148885755	148885755	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr3:148885755C>A	uc003ewu.1	+	15	3012	c.2872C>A	c.(2872-2874)Ctg>Atg	p.L958M	CP_uc011bnr.2_Intron|HPS3_uc011bnq.1_Missense_Mutation_p.L793M|HPS3_uc003ewv.1_Non-coding_Transcript	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Homo sapiens Hermansky-Pudlak syndrome 3 (HPS3), mRNA.	958						cytoplasm				breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	34			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TCAACTCTACCTGTCATCATT	0.299000									Hermansky-Pudlak syndrome				21	30					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15278212	15278212	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:15278212G>A	uc002nan.3	-	28	5286	c.5210C>T	c.(5209-5211)cCa>cTa	p.P1737L		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Homo sapiens notch 3 (NOTCH3), mRNA.	1737					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi lumen|cytosol|endoplasmic reticulum lumen|extracellular region|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCCCATGCCTGGCTCCTCTAC	0.622000													25	41					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225362501	225362501	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr2:225362501A>C	uc010fwy.1	-	11	1747	c.1694T>G	c.(1693-1695)cTc>cGc	p.L565R	CUL3_uc010zls.1_Missense_Mutation_p.L493R|CUL3_uc002vny.2_Missense_Mutation_p.L559R	NM_003590	NP_003581	Q13618	CUL3_HUMAN	Homo sapiens cullin 3 (CUL3), mRNA.	559					G1/S transition of mitotic cell cycle|cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TGTGGCATTGAGATCTGCAGA	0.353000													32	63					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47694671	47694671	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr16:47694671G>A	uc002eev.4	+	21	2189	c.2137G>A	c.(2137-2139)Gat>Aat	p.D713N	PHKB_uc002eeu.4_Missense_Mutation_p.D706N	NM_000293	NP_000284	Q93100	KPBB_HUMAN	Homo sapiens phosphorylase kinase, beta (PHKB), transcript variant 1, mRNA.	713					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				ACAGCAGCCGGATGTCAACAT	0.463000													66	76					0	0	1	0	0
ODF1	4956	broad.mit.edu	37	8	103564150	103564150	+	Silent	SNP	C	C	T	rs150929068		TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr8:103564150C>T	uc003ykt.2	+	0	303	c.195C>T	c.(193-195)tgC>tgT	p.C65C		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	Homo sapiens outer dense fiber of sperm tails 1 (ODF1), mRNA.	65	2 X 5 AA repeats of [RC]-C-L-C-D.				cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CACGCTCTTGCGGCCTGTGTG	0.507000													5	368					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38633280	38633280	+	Silent	SNP	C	C	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:38633280C>A	uc002ohk.3	+	11	3972	c.3463C>A	c.(3463-3465)Cga>Aga	p.R1155R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 3 (SIPA1L3), mRNA.	1155					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCTCCCTACCGACAGCCTTC	0.572000											OREG0025445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	132	225					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169173727	169173727	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr4:169173727C>T	uc003irp.3	-	26	3930	c.3638G>A	c.(3637-3639)tGt>tAt	p.C1213Y		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60), mRNA.	1213							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CTTCTCTAGACACTTCACTAG	0.388000													65	112					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21854677	21854677	+	Silent	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:21854677G>A	uc003zph.3	+	5	611	c.498G>A	c.(496-498)aaG>aaA	p.K166K	MTAP_uc003zpi.1_Intron|MTAP_uc010mit.3_Non-coding_Transcript|MTAP_uc011lnk.2_Silent_p.K183K|MTAP_uc011lnl.2_Silent_p.K99K	NM_002451	NP_002442	Q13126	MTAP_HUMAN	Homo sapiens methylthioadenosine phosphorylase (MTAP), mRNA.	166					nucleoside metabolic process	cytoplasm	S-methyl-5-thioadenosine phosphorylase activity|phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	GCCACTCAAAGGGGACAATGG	0.473000													40	62					0	0	1	0	0
AL117485	0	broad.mit.edu	37	22	18845990	18845990	+	RNA	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr22:18845990C>T	uc002zoe.3	+	4		c.2352C>T			AL117485_uc002zof.3_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		ACCTCCATCCCGTCCTGCGCA	0.582000													8	42					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58490217	58490217	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr19:58490217G>C	uc002qqw.3	-	6	2449	c.1831C>G	c.(1831-1833)Ctc>Gtc	p.L611V	ZNF606_uc010yhp.2_Missense_Mutation_p.L521V	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	Homo sapiens zinc finger protein 606 (ZNF606), mRNA.	611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGTTTAGTGAGGGCTGAGCGT	0.433000													44	43					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38651315	38651315	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr3:38651315G>A	uc021wvo.1	-	5	896	c.844C>T	c.(844-846)Cgc>Tgc	p.R282C	SCN5A_uc021wvk.1_Missense_Mutation_p.R282C|SCN5A_uc021wvl.1_Missense_Mutation_p.R282C|SCN5A_uc021wvm.1_Missense_Mutation_p.R282C|SCN5A_uc021wvn.1_Missense_Mutation_p.R282C|SCN5A_uc021wvp.1_Missense_Mutation_p.R282C|SCN5A_uc021wvq.1_Missense_Mutation_p.R282C|SCN5A_uc021wvr.1_Missense_Mutation_p.R282C|SCN5A_uc021wvs.1_Missense_Mutation_p.R282C|SCN5A_uc021wvt.1_Missense_Mutation_p.R282C|SCN5A_uc021wvu.1_Missense_Mutation_p.R282C|SCN5A_uc021wvv.1_Missense_Mutation_p.R282C|SCN5A_uc021wvj.1_Missense_Mutation_p.R148C|SCN5A_uc021wvi.1_Missense_Mutation_p.R148C|SCN5A_uc010hhl.1_Missense_Mutation_p.R105C	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	Homo sapiens sodium channel, voltage-gated, type V, alpha subunit (SCN5A), transcript variant 1, mRNA.	282			R -> H (in BRS1).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGAAGTTGCGCACGCACTTG	0.587000													57	55					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740871	37740871	+	Silent	SNP	C	C	G			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:37740871C>G	uc004aag.1	+	14	2390	c.2346C>G	c.(2344-2346)ggC>ggG	p.G782G	FRMPD1_uc004aah.1_Silent_p.G782G|FRMPD1_uc011lqm.2_Silent_p.G604G|FRMPD1_uc011lqn.2_Silent_p.G651G	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	Homo sapiens FERM and PDZ domain containing 1 (FRMPD1), mRNA.	782						cytoskeleton|cytosol|plasma membrane		p.P781S(1)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTCCCCCAGGCCCCCCGTCAG	0.637000													19	39					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904578	5904578	+	Silent	SNP	C	C	T			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr20:5904578C>T	uc002wmg.3	+	3	2094	c.1788C>T	c.(1786-1788)gaC>gaT	p.D596D	CHGB_uc010zqz.2_Silent_p.D279D	NM_001819	NP_001810	P05060	SCG1_HUMAN	Homo sapiens chromogranin B (secretogranin 1) (CHGB), mRNA.	596						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CCAAGCTGGACCTGAAAAGGC	0.517000													7	64					0	0	1	0	0
DLX2	1746	broad.mit.edu	37	2	172967129	172967131	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr2:172967129_172967131delGCT	uc002uhn.3	-	0	348_350	c.136_138delAGC	c.(136-138)agcdel	p.S46del	DLX2_uc010zdx.1_In_Frame_Del_p.S46del	NM_004405	NP_004396	Q07687	DLX2_HUMAN	Homo sapiens distal-less homeobox 2 (DLX2), mRNA.	46	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GCTTGTGGAGgctgctgctgctg	0.739													2	4	---	---	---	---					
CADPS2	93664	broad.mit.edu	37	7	122303546	122303546	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr7:122303546delA	uc022akp.1	-	2	953	c.531delT	c.(529-531)tttfs	p.F177fs	CADPS2_uc022akq.1_Frame_Shift_Del_p.F177fs|CADPS2_uc010lkq.3_Frame_Shift_Del_p.F177fs|CADPS2_uc022akr.1_Frame_Shift_Del_p.F177fs	NM_001167940	NP_001161412	Q86UW7	CAPS2_HUMAN	Homo sapiens Ca++-dependent secretion activator 2 (CADPS2), transcript variant 3, mRNA.	177					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TGTTTTTCTTAAATACTTCTC	0.398													14	6	---	---	---	---					
PTGR1	22949	broad.mit.edu	37	9	114345847	114345848	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr9:114345847_114345848delGT	uc010mue.3	-	5	662_663	c.399_400delAC	c.(397-402)ctacttfs	p.L133fs	PTGR1_uc011lwr.2_Frame_Shift_Del_p.L133fs|PTGR1_uc004bfh.2_Frame_Shift_Del_p.L133fs|PTGR1_uc004bfi.3_Frame_Shift_Del_p.L133fs|PTGR1_uc004bfj.3_Frame_Shift_Del_p.L10fs	NM_001146109	NP_001139581	Q14914	PTGR1_HUMAN	Homo sapiens prostaglandin reductase 1 (PTGR1), transcript variant 3, mRNA.	133					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)	11						CAGATTTCAAGTAGGCCAAAGT	0.421													33	180	---	---	---	---					
LOC441666	441666	broad.mit.edu	37	10	42833086	42833087	+	RNA	DEL	TA	TA	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr10:42833086_42833087delTA	uc010qey.2	-	2		c.888_889delTA								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		CAGTATGAACTATGTTATGTTG	0.361													6	5	---	---	---	---					
FOXA1	3169	broad.mit.edu	37	14	38061223	38061228	+	In_Frame_Del	DEL	TCTCGA	TCTCGA	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr14:38061223_38061228delTCTCGA	uc001wuf.3	-	1	1073_1078	c.761_766delTCGAGA	c.(760-768)ttcgagaac>tac	p.254_256FEN>Y	FOXA1_uc010tpz.2_In_Frame_Del_p.221_223FEN>Y	NM_004496	NP_004487	P55317	FOXA1_HUMAN	Homo sapiens forkhead box A1 (FOXA1), mRNA.	254					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.M253R(2)|p.M253K(2)		breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TAGCAGCCGTTCTCGAACATGTTGCC	0.689													19	26	---	---	---	---					
PHOSPHO1	162466	broad.mit.edu	37	17	47302390	47302392	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-QU-A6IL-01A-11D-A31L-08	TCGA-QU-A6IL-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d5ce82e-de92-420b-abab-003d7bee208e	c2fe33a1-6c76-42e6-9708-e7ea911d2f85	g.chr17:47302390_47302392delAGG	uc002ios.2	-	2	513_515	c.95_97delCCT	c.(94-99)tcctgc>tgc	p.S32del	PHOSPHO1_uc010wlv.1_Intron|PHOSPHO1_uc021tzr.1_In_Frame_Del_p.S32del	NM_001143804	NP_001137276	Q8TCT1	PHOP1_HUMAN	Homo sapiens phosphatase, orphan 1 (PHOSPHO1), transcript variant 1, mRNA.	0					regulation of bone mineralization		metal ion binding|phosphoethanolamine/phosphocholine phosphatase activity							Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)		Choline(DB00122)	ggagagcagcaggaggaggagga	0.700													2	4	---	---	---	---					
