Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD30BP2	149992	broad.mit.edu	37	21	14439208	14439208	+	RNA	SNP	A	A	G			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr21:14439208A>G	uc002yja.4	+	9		c.2726A>G								Homo sapiens ankyrin repeat domain 30B pseudogene 2 (ANKRD30BP2), non-coding RNA.																		AAGAGAAGAAATGCCAATATA	0.299000													9	26					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68614298	68614298	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr1:68614298C>T	uc001dee.3	-	6	1314	c.1012G>A	c.(1012-1014)Gga>Aga	p.G338R	GNG12-AS1_uc001deb.2_Intron|GNG12-AS1_uc001dec.2_Intron|WLS_uc001def.2_Missense_Mutation_p.G340R|WLS_uc001deg.2_Missense_Mutation_p.G249R|WLS_uc009wbf.1_Missense_Mutation_p.G295R	NM_001002292	NP_001002292	Q5T9L3	WLS_HUMAN	Homo sapiens wntless homolog (Drosophila) (WLS), transcript variant 2, mRNA.	340					Wnt receptor signaling pathway|multicellular organismal development|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of canonical Wnt receptor signaling pathway	Golgi membrane|cytoplasmic vesicle membrane|integral to membrane	signal transducer activity	p.Q338*(1)|p.K337N(1)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						GCAATGGGTCCGACTTGCTTC	0.512000													4	19					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061208	38061208	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr14:38061208G>A	uc001wuf.3	-	1	1093	c.781C>T	c.(781-783)Cgc>Tgc	p.R261C	FOXA1_uc010tpz.2_Missense_Mutation_p.R228C	NM_004496	NP_004487	P55317	FOXA1_HUMAN	Homo sapiens forkhead box A1 (FOXA1), mRNA.	261					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TTCTGGCGGCGCAAGTAGCAG	0.716000													7	10					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42169758	42169758	+	Missense_Mutation	SNP	C	C	A	rs140895306		TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr17:42169758C>A	uc002iff.1	-	7	1245	c.913G>T	c.(913-915)Ggg>Tgg	p.G305W	HDAC5_uc002ifd.1_Missense_Mutation_p.G304W|HDAC5_uc002ife.1_Missense_Mutation_p.G304W|HDAC5_uc010czp.1_Missense_Mutation_p.G304W|HDAC5_uc002ifh.2_Missense_Mutation_p.G304W	NM_001015053	NP_001015053	Q9UQL6	HDAC5_HUMAN	Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA.	304					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity (H3-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		CCCCCAGGCCCGGCACCTGTG	0.582000													4	58					0	0	1	0	0
PTPN4	5775	broad.mit.edu	37	2	120567473	120567473	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr2:120567473T>A	uc002tmf.1	+	1	815	c.44T>A	c.(43-45)gTa>gAa	p.V15E		NM_002830	NP_002821	P29074	PTN4_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) (PTPN4), mRNA.	15						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	ACCTACAATGTACGAGCATCA	0.403000													3	51					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71952952	71952952	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr15:71952952G>T	uc002atb.1	+	6	1315	c.1236G>T	c.(1234-1236)caG>caT	p.Q412H	THSD4_uc002atd.1_Missense_Mutation_p.Q86H|THSD4_uc010ukg.1_Missense_Mutation_p.Q52H|THSD4_uc002ate.2_Missense_Mutation_p.Q52H	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	Homo sapiens thrombospondin, type I, domain containing 4 (THSD4), mRNA.	412						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CGGGCTGTCAGGTTGTGTCGG	0.542000													46	104					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65907564	65907564	+	Silent	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr17:65907564C>T	uc002jgf.3	+	10	3625	c.3564C>T	c.(3562-3564)gaC>gaT	p.D1188D	BPTF_uc002jge.3_Silent_p.D1314D	NM_182641	NP_872579	Q12830	BPTF_HUMAN	Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA.	1314					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex|cytoplasm	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTGAAAATGACATAGAAGAAA	0.378000													13	10					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87726074	87726074	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr6:87726074C>T	uc003pli.3	+	1	1725	c.1022C>T	c.(1021-1023)cCt>cTt	p.P341L	HTR1E_uc021zcg.1_Missense_Mutation_p.P341L	NM_000865	NP_000856	P28566	5HT1E_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1E (HTR1E), mRNA.	341					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CTGATCAACCCTCTGCTCTAT	0.433000													50	73					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654714	247654714	+	Silent	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr1:247654714C>T	uc001icz.2	+	0	345	c.285C>T	c.(283-285)caC>caT	p.H95H		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily W, member 5 (OR2W5), mRNA.	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H95H(2)		breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TCACCTACCACGGCTGTGTGG	0.557000													5	68					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14439185	14439185	+	RNA	SNP	C	C	A	rs112098339		TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr21:14439185C>A	uc002yja.4	+	9		c.2703C>A								Homo sapiens ankyrin repeat domain 30B pseudogene 2 (ANKRD30BP2), non-coding RNA.																		TGACTTTAAACCAAGAAGAAG	0.269000													9	27					0	0	1	0	0
HLCS	3141	broad.mit.edu	37	21	38311178	38311178	+	Silent	SNP	T	T	C			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr21:38311178T>C	uc010gnb.3	-	3	1420	c.6A>G	c.(4-6)gaA>gaG	p.E2E	HLCS_uc021wjb.1_Silent_p.E2E|HLCS_uc002yvs.3_Silent_p.E2E|HLCS_uc010gnc.2_Silent_p.E149E	NM_001242784	NP_001229713	P50747	BPL1_HUMAN	Homo sapiens holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (HLCS), transcript variant 3, mRNA.	2					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GGAGTCTATCTTCCATGAACG	0.458000													32	48					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37263465	37263465	+	Silent	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr22:37263465C>T	uc003apy.4	+	3	487	c.303C>T	c.(301-303)atC>atT	p.I101I	NCF4_uc003apz.4_Silent_p.I101I	NM_000631	NP_000622	Q15080	NCF4_HUMAN	Homo sapiens neutrophil cytosolic factor 4, 40kDa (NCF4), transcript variant 1, mRNA.	101	PX.				cell communication|immune response|oxidation-reduction process	NADPH oxidase complex|cytosol	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AACAGGAGATCGCCGAGATGC	0.607000													14	32					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50788105	50788105	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr15:50788105G>T	uc001zym.4	+	17	3219	c.2719G>T	c.(2719-2721)Gca>Tca	p.A907S	USP8_uc001zyl.4_Missense_Mutation_p.A907S|USP8_uc001zyn.4_Missense_Mutation_p.A907S|USP8_uc010ufh.2_Missense_Mutation_p.A801S|AX746640_uc001zyo.1_5'Flank|USP8_uc001zyp.4_Missense_Mutation_p.A74S	NM_001128611	NP_005145	P40818	UBP8_HUMAN	Homo sapiens ubiquitin specific peptidase 8 (USP8), transcript variant 3, mRNA.	907					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	SH3 domain binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTTTAAAGCTGCAGAACATGC	0.353000													17	19					0	0	1	0	0
ZRSR1	7310	broad.mit.edu	37	5	112228018	112228018	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr5:112228018G>A	uc021ycm.1	+	0	710	c.682G>A	c.(682-684)Gca>Aca	p.A228T	SRP19_uc011cvu.2_3'UTR|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_Intron|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron					RecName: Full=U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; AltName: Full=CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1; AltName: Full=U2(RNU2) small nuclear RNA auxiliary factor 1-like 1;											breast(1)|skin(1)|stomach(2)	4						TGACCCTGACGCAAGCCTGGA	0.448000													7	67					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48333127	48333127	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr18:48333127G>A	uc010dpa.3	-	2	384	c.235C>T	c.(235-237)Cgt>Tgt	p.R79C	MRO_uc010xdn.2_Missense_Mutation_p.R65C|MRO_uc002lew.4_Missense_Mutation_p.R65C|MRO_uc010dpb.3_Missense_Mutation_p.R79C|MRO_uc010dpc.3_Missense_Mutation_p.R65C|MRO_uc002lex.4_Missense_Mutation_p.R65C	NM_001127176	NP_001120648	Q9BYG7	MSTRO_HUMAN	Homo sapiens maestro (MRO), transcript variant 4, mRNA.	65						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		GCCATGTGACGCTTTTTAGCA	0.542000													12	121					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212779	26212779	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chrX:26212779T>A	uc022buc.1	+	0	816	c.816T>A	c.(814-816)agT>agA	p.S272R	MAGEB6_uc004dbr.3_Missense_Mutation_p.S272R	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	Homo sapiens melanoma antigen family B, 6 (MAGEB6), mRNA.	272	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						GCCTCCCCAGTGAAGGAATTC	0.532000													51	11					0	0	1	0	0
PRPF19	27339	broad.mit.edu	37	11	60658695	60658695	+	Silent	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr11:60658695G>A	uc001nqf.3	-	15	1665	c.1458C>T	c.(1456-1458)caC>caT	p.H486H		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	Homo sapiens PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) (PRPF19), mRNA.	486					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity	p.H486H(2)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						TGAACTTGGCGTGATGCCCGA	0.542000													13	20					0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	120452	120452	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chrGL000209.1:120452C>A	uc010yie.2	+	3	415	c.404C>A	c.(403-405)cCg>cAg	p.P135Q	KIR2DL2_uc021vdc.1_Intron|KIR2DL2_uc021vdd.1_Intron|KIR2DL2_uc002qty.3_Missense_Mutation_p.P132Q|KIR2DL2_uc002qum.3_Missense_Mutation_p.P135Q	NM_014512	NP_055327	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 (KIR2DS1), mRNA.	135					regulation of immune response	integral to membrane|plasma membrane	receptor activity										TCAGCCCAGCCGGGCCCCACG	0.562000													31	85					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98222052	98222052	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr9:98222052C>T	uc004avk.4	-	16	2905	c.2717G>A	c.(2716-2718)cGt>cAt	p.R906H	PTCH1_uc010mro.3_Missense_Mutation_p.R755H|PTCH1_uc010mrp.3_Missense_Mutation_p.R755H|PTCH1_uc010mrq.3_Missense_Mutation_p.R755H|PTCH1_uc004avl.4_Missense_Mutation_p.R755H|PTCH1_uc004avm.4_Missense_Mutation_p.R905H|PTCH1_uc010mrr.3_Missense_Mutation_p.R840H	NM_000264	NP_001077076	Q13635	PTC1_HUMAN	Homo sapiens patched 1 (PTCH1), transcript variant 1b, mRNA.	906					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.Q905*(1)|p.Q905fs*20(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				ATCCACCAGACGCTGTTTAGT	0.537000													4	31					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42860182	42860182	+	Splice_Site	SNP	T	T	C			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr12:42860182T>C	uc010skv.2	-	6	876	c.589_splice	c.e6-1	p.I197_splice	PRICKLE1_uc001rnl.3_Splice_Site_p.I197_splice|PRICKLE1_uc010skw.2_Splice_Site_p.I197_splice|PRICKLE1_uc001rnm.3_Splice_Site_p.I197_splice	NM_001144881	NP_694571	Q96MT3	PRIC1_HUMAN	Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 2, mRNA.	197	LIM zinc-binding 2.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GCAAAAATTATCTTCAAAAAG	0.433000													19	21					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62813870	62813870	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr4:62813870G>A	uc010ihh.3	+	13	2650	c.2477G>A	c.(2476-2478)cGt>cAt	p.R826H	LPHN3_uc003hcq.4_Missense_Mutation_p.R826H|LPHN3_uc003hct.3_Missense_Mutation_p.R219H	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	Homo sapiens latrophilin 3 (LPHN3), mRNA.	813	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.R826H(4)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TACTCCAAGCGTACAATGACA	0.383000													11	13					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18923109	18923109	+	Silent	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr17:18923109C>T	uc002gut.1	+	12	1583	c.1542C>T	c.(1540-1542)tgC>tgT	p.C514C	SLC5A10_uc002gur.1_Silent_p.C468C|SLC5A10_uc002guu.1_Silent_p.C498C|SLC5A10_uc002guv.1_Silent_p.C471C|SLC5A10_uc010vyl.1_Silent_p.C462C	NM_152351	NP_689564	A0PJK1	SC5AA_HUMAN	Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 10 (SLC5A10), transcript variant 1, mRNA.	498					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						CCCCACCGTGCGGAGAGCCAG	0.667000													9	7					0	0	1	0	0
UHRF2	115426	broad.mit.edu	37	9	6504676	6504676	+	Silent	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr9:6504676C>T	uc003zjy.3	+	14	2587	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F	UHRF2_uc003zjz.3_Non-coding_Transcript|UHRF2_uc003zkb.3_Non-coding_Transcript	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	Homo sapiens ubiquitin-like with PHD and ring finger domains 2 (UHRF2), mRNA.	749					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		CTGAGTGCTTCCACAATGTCT	0.383000													9	11					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688043	27688043	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr10:27688043A>G	uc001itu.2	-	3	1602	c.1484T>C	c.(1483-1485)aTc>aCc	p.I495T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	Homo sapiens patched domain containing 3 (PTCHD3), mRNA.	495	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GATGTTAGTGATGGTGGTGAT	0.403000													30	42					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103468003	103468003	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr1:103468003T>A	uc001dum.3	-	22	2432	c.2114A>T	c.(2113-2115)cAa>cTa	p.Q705L	COL11A1_uc001duk.3_5'UTR|COL11A1_uc001dul.3_Missense_Mutation_p.Q693L|COL11A1_uc001dun.3_Missense_Mutation_p.Q654L|COL11A1_uc009weh.3_Missense_Mutation_p.Q577L	NM_080629	NP_542196	P12107	COBA1_HUMAN	Homo sapiens collagen, type XI, alpha 1 (COL11A1), transcript variant B, mRNA.	693	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGATTCCCTTGTTGACCTGG	0.433000													7	11					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr3:178952085A>G	uc003fjk.3	+	20	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	Homo sapiens phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA), mRNA.	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		T cell costimulation|T cell receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(3170)|p.H1047L(409)|p.H1047Y(46)|p.A1046T(6)|p.H1047Q(3)|p.A1046E(2)|p.H1047P(2)|p.A1046V(2)|p.A1046A(1)|p.H1047T(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			22	41					0	0	1	0	0
FAM123C	205147	broad.mit.edu	37	2	131521766	131521766	+	Silent	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr2:131521766G>A	uc021voy.1	+	0	2121	c.2121G>A	c.(2119-2121)ggG>ggA	p.G707G	FAM123C_uc002trw.2_Silent_p.G707G|FAM123C_uc010fmv.2_Silent_p.G707G|FAM123C_uc010fms.1_Silent_p.G707G|FAM123C_uc010fmt.1_Silent_p.G707G|FAM123C_uc010fmu.1_Silent_p.G707G	NM_152698	NP_689911	Q8N944	F123C_HUMAN	Homo sapiens family with sequence similarity 123C (FAM123C), transcript variant 1, mRNA.	707										breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(43)|ovary(2)|pancreas(4)|prostate(3)|skin(8)	73	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGCTCTTTGGGCAGCGCTGGG	0.642000													5	26					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43913222	43913222	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr1:43913222T>A	uc001cjk.2	+	65	9206	c.6596T>A	c.(6595-6597)tTg>tAg	p.L2199*	SZT2_uc001cjl.2_Nonsense_Mutation_p.L187*	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	Homo sapiens seizure threshold 2 homolog (mouse) (SZT2), mRNA.	3098						peroxisome		p.L2199L(1)		NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TCAGGGACATTGGAGCTCCCC	0.552000													29	47					0	0	1	0	0
CELF1	10658	broad.mit.edu	37	11	47493882	47493882	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr11:47493882G>A	uc001nfp.3	-	14	1847	c.1445C>T	c.(1444-1446)tCg>tTg	p.S482L	CELF1_uc001nfl.3_Missense_Mutation_p.S454L|CELF1_uc010rhm.2_Missense_Mutation_p.S453L|CELF1_uc001nfm.3_Missense_Mutation_p.S451L|CELF1_uc001nfk.2_Missense_Mutation_p.S480L|CELF1_uc001nfn.3_Missense_Mutation_p.S450L|CELF1_uc001nfr.1_Missense_Mutation_p.S454L	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	Homo sapiens CUGBP, Elav-like family member 1 (CELF1), transcript variant 3, mRNA.	454					RNA interference|embryo development|mRNA splice site selection|regulation of RNA splicing	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						AGCTTGGGCCGAAACAGGATT	0.483000													4	145					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17855689	17855689	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr6:17855689C>T	uc003ncg.4	-	5	633	c.473G>A	c.(472-474)cGg>cAg	p.R158Q	KIF13A_uc003ncf.3_Missense_Mutation_p.R158Q|KIF13A_uc003nch.4_Missense_Mutation_p.R158Q|KIF13A_uc003nci.4_Missense_Mutation_p.R158Q	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	Homo sapiens kinesin family member 13A (KIF13A), transcript variant 1, mRNA.	158	Kinesin-motor.				Golgi to plasma membrane protein transport|cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding	p.R158W(1)		breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TAAAAGATCCCGAACTTTCTC	0.338000													3	59					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750559	94750559	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr4:94750559G>A	uc003hta.1	+	0	482	c.482G>A	c.(481-483)cGg>cAg	p.R161Q		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	Homo sapiens atonal homolog 1 (Drosophila) (ATOH1), mRNA.	161					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		AAGCAGAGACGGCTAGCAGCC	0.617000													29	26					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726592	46726592	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr11:46726592C>T	uc001nde.2	+	4	1623	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	ZNF408_uc010rgw.2_Missense_Mutation_p.R440C	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	Homo sapiens zinc finger protein 408 (ZNF408), transcript variant 1, mRNA.	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGCCTTTGCCCGCCGGCCCTC	0.672000													9	80					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38182576	38182576	+	Silent	SNP	A	A	C			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr17:38182576A>C	uc002hts.3	-	17	2093	c.1893T>G	c.(1891-1893)acT>acG	p.T631T	MED24_uc010wer.2_5'Flank|MED24_uc010wes.2_Silent_p.T466T|MED24_uc010wet.2_Intron|MED24_uc002htt.3_Silent_p.T606T|MED24_uc002htu.3_Silent_p.T593T|MED24_uc010cwn.3_Silent_p.T593T|MED24_uc010weu.2_Silent_p.T516T|MED24_uc010wev.1_Silent_p.T556T|MED24_uc010wew.1_Silent_p.T547T|SNORD124_uc010wey.2_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	Homo sapiens mediator complex subunit 24 (MED24), transcript variant 1, mRNA.	606					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	RNA polymerase II transcription cofactor activity|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					TGATGTTATCAGTGATTTTCT	0.557000													39	63					0	0	1	0	0
CCDC48	79825	broad.mit.edu	37	3	128758620	128758620	+	Silent	SNP	T	T	C			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr3:128758620T>C	uc011bkt.2	+	7	1726	c.1726T>C	c.(1726-1728)Ttg>Ctg	p.L576L		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	Homo sapiens coiled-coil domain containing 48 (CCDC48), mRNA.	576										breast(1)|kidney(2)|lung(2)|skin(1)	6						CTGCCAGCTGTTGCGGAGACA	0.667000													6	85					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776169	38776169	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr4:38776169G>A	uc003gtj.3	-	3	1681	c.1043C>T	c.(1042-1044)aCg>aTg	p.T348M	TLR10_uc021xnk.1_Missense_Mutation_p.T334M|TLR10_uc003gti.3_Missense_Mutation_p.T348M|TLR10_uc021xnl.1_Missense_Mutation_p.T348M|TLR10_uc003gtk.3_Missense_Mutation_p.T348M|TLR10_uc021xnm.1_Missense_Mutation_p.T348M	NM_030956	NP_001182037	Q9BXR5	TLR10_HUMAN	Homo sapiens toll-like receptor 10 (TLR10), transcript variant 1, mRNA.	348					MyD88-dependent toll-like receptor signaling pathway|inflammatory response|innate immune response	integral to membrane|plasma membrane	transmembrane receptor activity	p.T348T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						TTGGAATTTCGTAGGATAATT	0.333000													38	46					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5352528	5352530	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-QU-A6IN-01A-11D-A31L-08	TCGA-QU-A6IN-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f8799b1d-3e1e-4d2a-ac5c-63509cd01c8b	9a41f5ef-4649-44de-883f-c7c0c4ee5de4	g.chr7:5352528_5352530delGAG	uc003soi.4	-	26	8341_8343	c.7992_7994delCTC	c.(7990-7995)tcctct>tct	p.2664_2665SS>S		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	Homo sapiens trinucleotide repeat containing 18 (TNRC18), mRNA.	2664	Ser-rich.						DNA binding	p.S2671delS(2)|p.P1177delP(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		agaggaggaagaggaggaggagg	0.640													2	4	---	---	---	---					
