Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LSP1	4046	broad.mit.edu	37	11	1901362	1901362	+	Missense_Mutation	SNP	C	C	A	rs150172209		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:1901362C>A	uc001lui.3	+	1	274	c.99C>A	c.(97-99)caC>caA	p.H33Q	LSP1_uc001luj.3_Missense_Mutation_p.H161Q|LSP1_uc001luk.3_5'UTR|LSP1_uc001lul.3_5'UTR|LSP1_uc001lum.3_5'UTR	NM_002339	NP_001013273	P33241	LSP1_HUMAN	Homo sapiens lymphocyte-specific protein 1 (LSP1), transcript variant 1, mRNA.	33					cellular component movement|cellular defense response	Golgi apparatus|actin cytoskeleton|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		AGGCCGTCCACGAGCAATGCC	0.647000													8	34					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80739569	80739569	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr17:80739569T>C	uc002kfy.1	+	6	873	c.743T>C	c.(742-744)aTc>aCc	p.I248T	TBCD_uc002kfx.1_Missense_Mutation_p.I231T|TBCD_uc002kfz.3_Missense_Mutation_p.I248T	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	Homo sapiens tubulin folding cofactor D (TBCD), mRNA.	248					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	GTPase activator activity|beta-tubulin binding|chaperone binding					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CAGGGGGTCATCACCATGGAT	0.587000											OREG0024827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	66					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526716	32526716	+	Missense_Mutation	SNP	C	C	T	rs77092908	byFrequency	TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr21:32526716C>T	uc002yow.1	-	17	3492	c.3020G>A	c.(3019-3021)cGc>cAc	p.R1007H	TIAM1_uc011adk.1_Missense_Mutation_p.R1007H|TIAM1_uc011adl.1_Missense_Mutation_p.R947H	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	Homo sapiens T-cell lymphoma invasion and metastasis 1 (TIAM1), mRNA.	1007					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	Rho guanyl-nucleotide exchange factor activity|receptor signaling protein activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATGCAAACTGCGGCAAAATGC	0.577000													4	105					0	0	1	0	0
PTRH1	138428	broad.mit.edu	37	9	130477855	130477855	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:130477855A>G	uc004bro.3	-	0	1384	c.64T>C	c.(64-66)Ttg>Ctg	p.L22L	PTRH1_uc004brm.3_Silent_p.L22L|PTRH1_uc010mxm.3_Silent_p.L35L|PTRH1_uc011mah.2_Silent_p.L22L|TTC16_uc004brq.1_5'Flank|TTC16_uc011mai.1_5'Flank|TTC16_uc004brr.1_5'Flank	NM_001002913	NP_001002913	Q86Y79	PTH_HUMAN	Homo sapiens peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) (PTRH1), mRNA.	22					translation		aminoacyl-tRNA hydrolase activity|protein binding			NS(1)	1						CGAGGCTCCAAAACACATCGG	0.677000													14	24					0	0	1	0	0
GUSBP11	91316	broad.mit.edu	37	22	23980782	23980782	+	RNA	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr22:23980782G>A	uc002zxh.4	-	4		c.3708C>T			GUSBP11_uc002zxi.4_Non-coding_Transcript|GUSBP11_uc002zxk.4_Non-coding_Transcript|GUSBP11_uc010gua.3_Non-coding_Transcript|GUSBP11_uc002zxl.4_Non-coding_Transcript|GUSBP11_uc011aiz.2_Non-coding_Transcript					Homo sapiens glucuronidase, beta pseudogene 11 (GUSBP11), non-coding RNA.																		GCAGCTCCAGGCCCCTGTGGG	0.567000													9	17					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140719242	140719242	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr5:140719242C>T	uc003ljk.2	+	0	889	c.704C>T	c.(703-705)gCg>gTg	p.A235V	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc011dao.2_Missense_Mutation_p.A235V	NM_018915	NP_061738	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 2 (PCDHGA2), transcript variant 1, mRNA.	235	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A235V(2)		breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTGGATGCGAACGACAAT	0.592000													4	81					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67154846	67154846	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:67154846C>T	uc001dcr.3	+	15	1548	c.1331C>T	c.(1330-1332)gCt>gTt	p.A444V	SGIP1_uc010opd.2_Missense_Mutation_p.A44V|SGIP1_uc001dcs.3_Missense_Mutation_p.A44V|SGIP1_uc001dct.3_Missense_Mutation_p.A44V|SGIP1_uc009wat.3_Missense_Mutation_p.A238V	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	Homo sapiens SH3-domain GRB2-like (endophilin) interacting protein 1 (SGIP1), mRNA.	444	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	SH3 domain binding|microtubule binding|phospholipid binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TCATCCCCTGCTCGACCAGCC	0.537000													8	382					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310294	24310294	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr19:24310294T>G	uc002nru.3	+	3	1626	c.1492T>G	c.(1492-1494)Tct>Gct	p.S498A	ZNF254_uc010xrk.2_Missense_Mutation_p.S413A	NM_203282	NP_975011	O75437	ZN254_HUMAN	Homo sapiens zinc finger protein 254 (ZNF254), mRNA.	498					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408000													3	68					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34312500	34312500	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:34312500C>T	uc002xeb.3	-	7	1088	c.679G>A	c.(679-681)Gca>Aca	p.A227T	RBM39_uc002xdz.3_Missense_Mutation_p.A203T|RBM39_uc010gfn.3_Missense_Mutation_p.A70T|RBM39_uc002xef.3_Missense_Mutation_p.A70T|RBM39_uc010zvn.2_Missense_Mutation_p.A70T|RBM39_uc002xec.3_Missense_Mutation_p.A227T|RBM39_uc010zvm.2_Missense_Mutation_p.A205T|RBM39_uc002xeg.3_Missense_Mutation_p.A205T|RBM39_uc002xed.3_5'UTR|RBM39_uc002xee.3_Missense_Mutation_p.A70T	NM_184234	NP_909122	Q14498	RBM39_HUMAN	Homo sapiens RNA binding motif protein 39 (RBM39), transcript variant 1, mRNA.	227	RRM 1.				RNA splicing|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nuclear speck	RNA binding|nucleotide binding|protein binding	p.A227T(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					ACCTGTGATGCCTGTACTATG	0.433000													20	58					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38933946	38933946	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr17:38933946A>G	uc002hvg.3	-	5	1052	c.1011T>C	c.(1009-1011)agT>agC	p.S337S		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	Homo sapiens keratin 27 (KRT27), mRNA.	337	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity	p.S337R(2)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				CACAGTAGTTACTCTCGGTCT	0.527000													36	156					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50168708	50168708	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr15:50168708G>T	uc001zxu.3	-	24	2936	c.2794C>A	c.(2794-2796)Cag>Aag	p.Q932K	ATP8B4_uc010ber.3_Missense_Mutation_p.Q805K|ATP8B4_uc010ufd.2_Missense_Mutation_p.Q742K|ATP8B4_uc010ufe.2_Non-coding_Transcript|ATP8B4_uc001zxt.3_5'UTR	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	Homo sapiens ATPase, class I, type 8B, member 4 (ATP8B4), mRNA.	932					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		ACGCTGTTCTGGTCACTCACA	0.423000													12	39					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130506867	130506867	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:130506867C>T	uc004bsc.3	-	6	1918	c.1776G>A	c.(1774-1776)cgG>cgA	p.R592R	SH2D3C_uc010mxo.3_Silent_p.R432R|SH2D3C_uc004bry.3_Silent_p.R434R|SH2D3C_uc004brz.4_Silent_p.R238R|SH2D3C_uc011mak.2_Silent_p.R238R|SH2D3C_uc004bsb.3_Silent_p.R524R|SH2D3C_uc004bsa.3_Silent_p.R435R	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 1, mRNA.	592	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	SH3/SH2 adaptor activity|guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGGTGACATGCCGGGCCAGCG	0.632000													4	129					0	0	1	0	0
HOXD4	3233	broad.mit.edu	37	2	177016758	177016758	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:177016758G>A	uc002uks.3	+	0	646	c.397G>A	c.(397-399)Gtc>Atc	p.V133I		NM_014621	NP_055436	P09016	HXD4_HUMAN	Homo sapiens homeobox D4 (HOXD4), mRNA.	133						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GCCGGCCGTGGTCTACCCCTG	0.672000													6	45					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136256483	136256483	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:136256483T>G	uc004cdk.3	+	6	555	c.494T>G	c.(493-495)cTc>cGc	p.L165R	C9orf96_uc004cdl.3_Intron	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	Homo sapiens chromosome 9 open reading frame 96 (C9orf96), mRNA.	165	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		AACATCATCCTCATCAGCAGT	0.552000													17	335					0	0	1	0	0
RPL23AP32	56969	broad.mit.edu	37	2	54756736	54756736	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:54756736T>C	uc010yot.1	+	0	378	c.254T>C	c.(253-255)tTt>tCt	p.F85S	SPTBN1_uc002rxu.3_Intron|SPTBN1_uc002rxv.1_Intron					Homo sapiens ribosomal protein L23a pseudogene 32 (RPL23AP32), non-coding RNA.																		ACCACTGAGTTTGCCATGAAG	0.483000													3	36					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211438054	211438054	+	Silent	SNP	A	A	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:211438054A>T	uc010fur.3	+	2	259	c.177A>T	c.(175-177)ggA>ggT	p.G59G	CPS1_uc002vee.4_Silent_p.G53G	NM_001122633	NP_001116105	P31327	CPSM_HUMAN	Homo sapiens carbamoyl-phosphate synthase 1, mitochondrial (CPS1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	53	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGAAGATGGAACTAAGATGA	0.418000													35	67					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228238397	228238397	+	Silent	SNP	C	C	T	rs151253698		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:228238397C>T	uc001hrp.2	+	2	461	c.354C>T	c.(352-354)gcC>gcT	p.A118A	WNT3A_uc001hrq.2_Silent_p.A118A	NM_033131	NP_149122	P56704	WNT3A_HUMAN	Homo sapiens wingless-type MMTV integration site family, member 3A (WNT3A), mRNA.	118					Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway|axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TTGCCTCAGCCGGTGTGGCCT	0.622000													18	15					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55496573	55496573	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr19:55496573T>G	uc021vbq.1	+	6	2300	c.2189T>G	c.(2188-2190)cTc>cGc	p.L730R	NLRP2_uc010yfp.2_Missense_Mutation_p.L707R|NLRP2_uc002qij.3_Missense_Mutation_p.L730R|NLRP2_uc010esp.3_Missense_Mutation_p.L708R|NLRP2_uc010esn.3_Missense_Mutation_p.L706R|NLRP2_uc010eso.3_Missense_Mutation_p.L727R	NM_001174081	NP_060322	Q9NX02	NALP2_HUMAN	Homo sapiens NLR family, pyrin domain containing 2 (NLRP2), transcript variant 2, mRNA.	730					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACCTGTCATCTCCAGAGAGTG	0.403000													6	83					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406191	55406191	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:55406191C>T	uc010rij.2	+	0	358	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily P, member 4 (OR4P4), mRNA.	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D119Y(1)		autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						GGCCTATGACCGCTATGTGGC	0.403000													21	60					0	0	1	0	0
RPL23AP32	56969	broad.mit.edu	37	2	54756737	54756737	+	Silent	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:54756737T>C	uc010yot.1	+	0	379	c.255T>C	c.(253-255)ttT>ttC	p.F85F	SPTBN1_uc002rxu.3_Intron|SPTBN1_uc002rxv.1_Intron					Homo sapiens ribosomal protein L23a pseudogene 32 (RPL23AP32), non-coding RNA.																		CCACTGAGTTTGCCATGAAGA	0.478000													3	38					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9798825	9798825	+	Silent	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:9798825G>A	uc003bsi.3	+	6	1372	c.1029G>A	c.(1027-1029)ccG>ccA	p.P343P	OGG1_uc003bsj.3_Missense_Mutation_p.R349Q|OGG1_uc003bsh.3_3'UTR|OGG1_uc003bsl.3_Intron|OGG1_uc003bsk.3_Intron|OGG1_uc003bsm.3_Intron|OGG1_uc003bsn.3_Intron|OGG1_uc003bso.3_Intron|OGG1_uc003bsr.2_Silent_p.P108P|OGG1_uc010hcm.2_Missense_Mutation_p.R136Q|OGG1_uc003bsq.2_Missense_Mutation_p.R58Q|OGG1_uc003bsp.2_Missense_Mutation_p.R114Q	NM_002542	NP_002533	O15527	OGG1_HUMAN	Homo sapiens 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a, mRNA.	343					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					CCAAAGGGCCGGAAGGCTAGA	0.602000								Base excision repair (BER), DNA glycosylases					4	128					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43056985	43056985	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:43056985C>T	uc002xma.3	+	8	1229	c.1140C>T	c.(1138-1140)agC>agT	p.S380S	HNF4A_uc002xlu.3_Silent_p.S358S|HNF4A_uc002xlv.3_Silent_p.S358S|HNF4A_uc010ggq.3_Silent_p.S373S|HNF4A_uc002xlz.3_Silent_p.S380S	NM_000457	NP_000448	P41235	HNF4A_HUMAN	Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2, mRNA.	380					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|activating transcription factor binding|protein homodimerization activity|receptor binding|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTCCCCCAGCGATGCACCCC	0.592000													21	71					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133928258	133928258	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:133928258C>T	uc004caa.1	+	10	1943	c.1845C>T	c.(1843-1845)gaC>gaT	p.D615D		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	Homo sapiens laminin, gamma 3 (LAMC3), mRNA.	615	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCTCCGAGGACGTGGCCCCTC	0.697000											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	63					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248569715	248569715	+	Silent	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:248569715G>A	uc010pzm.2	+	0	420	c.420G>A	c.(418-420)agG>agA	p.R140R		NM_030904	NP_112166	O43869	OR2T1_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily T, member 1 (OR2T1), mRNA.	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATCAAAGGACCATTTCCT	0.478000													15	144					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13592062	13592062	+	Silent	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:13592062C>A	uc003nay.3	+	4	723	c.411C>A	c.(409-411)gtC>gtA	p.V137V	SIRT5_uc003naw.3_Silent_p.V137V|SIRT5_uc003nax.3_Silent_p.V29V|SIRT5_uc011dit.2_Silent_p.V137V	NM_012241	NP_001229756	Q9NXA8	SIRT5_HUMAN	Homo sapiens sirtuin 5 (SIRT5), transcript variant 1, mRNA.	137	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	NAD+ ADP-ribosyltransferase activity|NAD+ binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GAGTCGTGGTCATCACCCAGA	0.652000													13	46					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108862482	108862482	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr13:108862482G>A	uc001vqn.3	-	1	1408	c.1135C>T	c.(1135-1137)Cat>Tat	p.H379Y	LIG4_uc001vqo.3_Missense_Mutation_p.H379Y|LIG4_uc010agf.3_Missense_Mutation_p.H379Y|LIG4_uc001vqp.3_Missense_Mutation_p.H379Y|LIG4_uc010agg.1_Missense_Mutation_p.H312Y|LIG4_uc021rmk.1_Missense_Mutation_p.H379Y	NM_002312	NP_996820	P49917	DNLI4_HUMAN	Homo sapiens ligase IV, DNA, ATP-dependent (LIG4), transcript variant 1, mRNA.	379					DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|T cell differentiation in thymus|T cell receptor V(D)J recombination|cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to X-ray|response to gamma radiation|single strand break repair|somatic stem cell maintenance	DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|condensed chromosome|cytoplasm|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AGAGTCTCATGCCCTAGCTTT	0.328000								Non-homologous end-joining					7	55					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689987	21689987	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:21689987C>T	uc002wsj.2	+	3	1241	c.1187C>T	c.(1186-1188)gCg>gTg	p.A396V	PAX1_uc010zsl.2_Missense_Mutation_p.A396V|PAX1_uc010zsm.2_Missense_Mutation_p.A372V	NM_006192	NP_006183	P15863	PAX1_HUMAN	Homo sapiens paired box 1 (PAX1), mRNA.	396					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.G395G(1)		autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						TGGCCGCCTGCGCAAGGTCCT	0.736000													5	17					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113321171	113321171	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr12:113321171G>A	uc010syl.2	+	15	1762	c.1400G>A	c.(1399-1401)gGc>gAc	p.G467D	RPH3A_uc001ttz.3_Missense_Mutation_p.G467D|RPH3A_uc001tty.3_Missense_Mutation_p.G463D|RPH3A_uc009zwe.1_Missense_Mutation_p.G463D|RPH3A_uc010sym.2_Missense_Mutation_p.G418D|RPH3A_uc001tua.3_Missense_Mutation_p.G227D	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	Homo sapiens rabphilin 3A homolog (mouse) (RPH3A), transcript variant 1, mRNA.	467	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GTGTATCACGGCATCACCGAT	0.562000													3	26					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48573435	48573435	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:48573435T>C	uc002rwh.1	+	2	397	c.82T>C	c.(82-84)Tac>Cac	p.Y28H		NM_002158	NP_002149	P32314	FOXN2_HUMAN	Homo sapiens forkhead box N2 (FOXN2), mRNA.	28					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			AAGCCAGATTTACAAAATGGG	0.463000													38	86					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41836190	41836190	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr8:41836190G>A	uc010lxb.3	-	6	1557	c.1013C>T	c.(1012-1014)cCa>cTa	p.P338L	KAT6A_uc010lxc.3_Missense_Mutation_p.P338L|KAT6A_uc003xon.4_Missense_Mutation_p.P338L|KAT6A_uc010lxd.3_Missense_Mutation_p.P338L	NM_001099412	NP_006757	Q92794	MYST3_HUMAN	Homo sapiens K(lysine) acetyltransferase 6A (KAT6A), transcript variant 1, mRNA.	338	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding	p.P338Q(1)									CCTGTTTTTTGGACGTCCTAT	0.403000													61	163					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158449735	158449735	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:158449735C>A	uc010pik.2	+	0	68	c.68C>A	c.(67-69)gCa>gAa	p.A23E	AK057554_uc001fso.1_Non-coding_Transcript	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily R, member 2 (OR10R2), mRNA.	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L22_A23>FS(1)|p.A23S(1)|p.L22F(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CAGATCTTGGCAGAAAACCTC	0.423000													12	112					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	106237754	106237754	+	RNA	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr14:106237754A>G	uc001ysh.1	-	0		c.1360T>C			abParts_uc021ser.1_Splice_Site|DKFZp686O16217_uc001yrs.3_Intron|DKFZp686O16217_uc001yrt.3_Intron|IGHE_uc001yrw.1_Intron|IGHE_uc001yrx.2_Intron|IGHE_uc001yrz.2_Intron|IGHG1_uc001yse.3_Intron|abParts_uc001ysi.1_Non-coding_Transcript					Homo sapiens mRNA for FLJ00385 protein.																		TGCAAGAGAGATGGCGCCATG	0.672000													5	51					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276100	186276100	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:186276100A>C	uc001gru.4	+	6	1300	c.1249A>C	c.(1249-1251)Acc>Ccc	p.T417P	MIR548F1_uc021pgf.1_Intron|PRG4_uc001grt.4_Missense_Mutation_p.T376P|PRG4_uc009wyl.3_Missense_Mutation_p.T324P|PRG4_uc009wym.3_Missense_Mutation_p.T283P|PRG4_uc010poo.2_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	Homo sapiens proteoglycan 4 (PRG4), transcript variant A, mRNA.	417	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T417P(2)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCACCAAGGAGCC	0.652000													10	107					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231299652	231299652	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:231299652A>C	uc009xfn.1	+	0	979	c.937A>C	c.(937-939)Atg>Ctg	p.M313L		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	Homo sapiens tripartite motif containing 67 (TRIM67), mRNA.	313						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GAACTACAGCATGTACTGCGT	0.672000													3	6					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45467247	45467247	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr10:45467247C>T	uc001jbp.3	+	1	1731	c.182C>T	c.(181-183)aCc>aTc	p.T61I	RASSF4_uc001jbo.3_Missense_Mutation_p.T30I|RASSF4_uc009xmn.3_Intron|RASSF4_uc001jbq.3_5'UTR			Q9H2L5	RASF4_HUMAN	Homo sapiens Ras association (RalGDS/AF-6) domain family member 4 (RASSF4), mRNA.	30					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTGCTGAAAACCTACAACTGC	0.562000													8	51					0	0	1	0	0
UBIAD1	29914	broad.mit.edu	37	1	11345718	11345718	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:11345718G>A	uc001asg.3	+	1	881	c.547G>A	c.(547-549)Gtg>Atg	p.V183M		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	Homo sapiens UbiA prenyltransferase domain containing 1 (UBIAD1), mRNA.	183					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity	p.V183M(2)		endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		ATTCAAGTACGTGGCTCTGGG	0.552000													4	54					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183521930	183521930	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:183521930C>T	uc003fly.2	+	26	3933	c.3738C>T	c.(3736-3738)gaC>gaT	p.D1246D	AX746590_uc003fma.1_3'UTR	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	Homo sapiens YEATS domain containing 2 (YEATS2), mRNA.	1246					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGAGGAATGACGGGGACTCCA	0.617000													4	156					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737056	157737056	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:157737056G>A	uc001fre.2	-	5	1186	c.1127C>T	c.(1126-1128)gCc>gTc	p.A376V	FCRL2_uc001frd.2_Missense_Mutation_p.A123V|FCRL2_uc010phz.1_Missense_Mutation_p.A376V|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Homo sapiens Fc receptor-like 2 (FCRL2), mRNA.	376	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	SH3/SH2 adaptor activity|receptor activity	p.G375W(2)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTGCACTGGGCCCCCAGGCC	0.572000													21	60					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76373050	76373050	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:76373050A>G	uc003pid.4	+	8	1429	c.810A>G	c.(808-810)ttA>ttG	p.L270L	SENP6_uc003pie.4_Silent_p.L263L|SENP6_uc003pic.2_Silent_p.L263L|SENP6_uc003pif.1_Silent_p.L161L	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	Homo sapiens SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1, mRNA.	270					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				ACACAGGATTAACAACCAAGA	0.343000													15	66					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72418283	72418283	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:72418283C>T	uc001osu.3	-	11	1849	c.1660G>A	c.(1660-1662)Ggg>Agg	p.G554R	ARAP1_uc001osv.3_Missense_Mutation_p.G554R|ARAP1_uc001osr.3_Missense_Mutation_p.G314R|ARAP1_uc001oss.3_Missense_Mutation_p.G309R|ARAP1_uc009yth.3_Missense_Mutation_p.G309R|ARAP1_uc010rre.2_Missense_Mutation_p.G309R	NM_001040118	NP_056057	Q96P48	ARAP1_HUMAN	Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1), transcript variant 3, mRNA.	554	Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	Golgi cisterna membrane|cytosol|plasma membrane	ARF GTPase activator activity|Rho GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						TGAGGAGCCCCGCAGTCAGCA	0.642000													4	6					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150415234	150415234	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr5:150415234C>T	uc003lti.3	-	13	1671	c.1430G>A	c.(1429-1431)cGc>cAc	p.R477H	TNIP1_uc011dcn.2_5'UTR|TNIP1_uc010jhq.2_Missense_Mutation_p.R424H|TNIP1_uc010jho.2_Non-coding_Transcript|TNIP1_uc010jhp.2_Missense_Mutation_p.R424H|TNIP1_uc010jhl.3_Non-coding_Transcript|TNIP1_uc010jhn.3_Missense_Mutation_p.R477H|TNIP1_uc010jhm.3_Missense_Mutation_p.R477H|TNIP1_uc010jhr.2_Missense_Mutation_p.R477H|TNIP1_uc011dco.2_Missense_Mutation_p.R477H|TNIP1_uc003ltg.3_Missense_Mutation_p.R424H|TNIP1_uc003ltk.3_Missense_Mutation_p.R477H|TNIP1_uc003ltj.3_Missense_Mutation_p.R477H|TNIP1_uc021ygb.1_Missense_Mutation_p.R477H	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	Homo sapiens TNFAIP3 interacting protein 1 (TNIP1), transcript variant 5, mRNA.	477					defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACGATCACTGCGCTCCCTCTG	0.577000													4	84					0	0	1	0	0
TEX26	122046	broad.mit.edu	37	13	31506874	31506874	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr13:31506874G>T	uc001uti.3	+	0	41	c.22G>T	c.(22-24)Gct>Tct	p.A8S	TEX26-AS1_uc001utg.2_5'Flank|TEX26-AS1_uc021rht.1_5'Flank	NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	Homo sapiens chromosome 13 open reading frame 26 (C13orf26), mRNA.	8																	TGGGCCCAGGGCTCCGGATCC	0.687000													6	23					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32622470	32622470	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:32622470A>T	uc010ogy.2	+	2	197	c.170A>T	c.(169-171)aAt>aTt	p.N57I	KPNA6_uc001bug.3_Missense_Mutation_p.N52I|KPNA6_uc001buh.3_5'UTR|KPNA6_uc010ogx.2_Missense_Mutation_p.N49I	NM_012316	NP_036448	O60684	IMA7_HUMAN	Homo sapiens karyopherin alpha 6 (importin alpha 7) (KPNA6), mRNA.	52	IBB.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AAACGGAGAAATGTGGAGCTG	0.413000													12	68					0	0	1	0	0
SCGB1C1	147199	broad.mit.edu	37	11	194572	194572	+	Splice_Site	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:194572C>A	uc001loa.1	+	3	431	c.411_splice	c.e3+1		ODF3_uc001lob.3_5'Flank|ODF3_uc010qvk.2_5'Flank|ODF3_uc001loc.3_5'Flank	NM_145651	NP_663626	Q8TD33	SG1C1_HUMAN	Homo sapiens secretoglobin, family 1C, member 1 (SCGB1C1), mRNA.							extracellular region	binding			endometrium(1)|liver(2)|lung(1)|skin(1)	5		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		AAGCCTCTTCCGCAGCTCAGG	0.562000													3	17					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49986788	49986788	+	Silent	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:49986788T>G	uc003pac.3	-	1	152	c.106A>C	c.(106-108)Aga>Cga	p.R36R	DEFB110_uc011dwr.2_Intron	NM_001037497	NP_001032586	Q30KQ9	DB110_HUMAN	Homo sapiens defensin, beta 110 locus (DEFB110), transcript variant 1, mRNA.	36					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					TTACCTATTCTGCACTCTCTC	0.393000													18	47					0	0	1	0	0
AK296065	0	broad.mit.edu	37	7	150773092	150773092	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr7:150773092C>A	uc011kvf.2	-	0	526	c.353G>T	c.(352-354)gGc>gTc	p.G118V	SLC4A2_uc022apz.1_Intron|SLC4A2_uc003wit.4_Intron|SLC4A2_uc011kve.2_Intron|SLC4A2_uc003wiu.4_Intron					SubName: Full=cDNA FLJ59028;																		CCTGTCTCCGCCCCCCAGGTC	0.657000													25	56					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35383221	35383221	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:35383221C>T	uc010gfr.3	-	9	1279	c.906G>A	c.(904-906)ctG>ctA	p.L302L	DSN1_uc002xfz.3_Silent_p.L302L|DSN1_uc002xfy.4_Silent_p.L92L|DSN1_uc010zvs.2_Silent_p.L195L|DSN1_uc002xga.3_Silent_p.L302L|DSN1_uc002xgc.3_Silent_p.L286L|DSN1_uc002xgb.3_Silent_p.L286L	NM_001145316	NP_001138790	Q9H410	DSN1_HUMAN	Homo sapiens DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (DSN1), transcript variant 1, mRNA.	302					cell division|chromosome segregation|mitotic prometaphase	MIS12/MIND type complex|cytosol|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TAAAGGCCTGCAGCTGTTTCA	0.473000													12	49					0	0	1	0	0
EOMES	8320	broad.mit.edu	37	3	27761814	27761814	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:27761814C>A	uc003cdy.3	-	1	884	c.884G>T	c.(883-885)cGc>cTc	p.R295L	EOMES_uc003cdx.3_Missense_Mutation_p.R295L|EOMES_uc010hfn.2_Missense_Mutation_p.R295L|EOMES_uc011axc.1_5'UTR	NM_005442	NP_005433	O95936	EOMES_HUMAN	Homo sapiens eomesodermin (EOMES), mRNA.	295					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						AGGAAACATGCGCCTGTGCAA	0.532000													12	124					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155646464	155646464	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:155646464T>C	uc010pgi.2	-	3	805	c.613A>G	c.(613-615)Atg>Gtg	p.M205V	GON4L_uc021paz.1_Missense_Mutation_p.M67V|GON4L_uc010pgg.2_Missense_Mutation_p.M1V|GON4L_uc010pgh.2_Missense_Mutation_p.M56V|GON4L_uc009wqt.3_Missense_Mutation_p.M56V|GON4L_uc001flh.3_Missense_Mutation_p.M205V|GON4L_uc001fll.3_Missense_Mutation_p.M67V|GON4L_uc001flk.3_Missense_Mutation_p.M56V|GON4L_uc001flm.3_Missense_Mutation_p.M56V|GON4L_uc009wqu.3_5'UTR|GON4L_uc009wqv.3_5'UTR|GON4L_uc009wqw.3_Missense_Mutation_p.M56V|GON4L_uc001flj.3_Missense_Mutation_p.M67V|GON4L_uc001fli.3_Missense_Mutation_p.M67V|GON4L_uc001flo.3_Missense_Mutation_p.M1V|GON4L_uc001fln.3_Missense_Mutation_p.M133V|GON4L_uc010pgj.2_Missense_Mutation_p.M133V|GON4L_uc001flp.3_Missense_Mutation_p.M67V|GON4L_uc009wqx.3_Missense_Mutation_p.M205V|GON4L_uc010pgk.2_Missense_Mutation_p.M205V	NM_001198903	NP_001185832	Q3T8J9	GON4L_HUMAN	Homo sapiens YY1 associated protein 1 (YY1AP1), transcript variant 10, mRNA.	656					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGTTTCTTCATCTTCAGCTGT	0.443000													16	74					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97808401	97808401	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:97808401T>G	uc010yva.2	+	6	1068	c.824T>G	c.(823-825)tTg>tGg	p.L275W	ANKRD36_uc021vlk.1_Intron|ANKRD36_uc010yuz.1_Non-coding_Transcript|ANKRD36_uc010fic.2_Silent_p.L18L|ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_Non-coding_Transcript	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.	275										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CAACCAGCCTTGAAGGTAATT	0.303000													3	29					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56114074	56114074	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:56114074G>T	uc010rjg.2	+	0	560	c.560G>T	c.(559-561)tGt>tTt	p.C187F		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily K, member 1 (OR8K1), mRNA.	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TACTGTGACTGTATCCCTCTG	0.353000										HNSCC(65;0.19)			4	90					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55370956	55370956	+	Frame_Shift_Del	DEL	C	C	-	rs140139106		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:55370956delC	uc010rii.2	-	0	919	c.894delG	c.(892-894)aagfs	p.K298fs		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 11 (OR4C11), mRNA.	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K298*(1)		endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						CATGCCATAACTTTCTCATGG	0.363													11	45	---	---	---	---					
CELF6	60677	broad.mit.edu	37	15	72582049	72582049	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr15:72582049delC	uc002aui.2	-	4	1445	c.984delG	c.(982-984)cggfs	p.R328fs	BC034424_uc002aug.3_Intron|CELF6_uc002auk.3_Non-coding_Transcript|CELF6_uc010biv.1_Non-coding_Transcript|CELF6_uc010ukl.1_Frame_Shift_Del_p.R107fs|CELF6_uc010biw.2_Frame_Shift_Del_p.R109fs|CELF6_uc002auh.2_Frame_Shift_Del_p.R222fs|CELF6_uc010ukm.1_Frame_Shift_Del_p.R222fs|CELF6_uc002auj.2_Frame_Shift_Del_p.R109fs	NM_001172685	NP_001166156	Q96J87	CELF6_HUMAN	Homo sapiens CUGBP, Elav-like family member 6 (CELF6), transcript variant 3, mRNA.	222					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	RNA binding|nucleotide binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						TCTGCTGCATCCGCCGCAGCG	0.751													2	4	---	---	---	---					
