Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
TAS1R3	83756	broad.mit.edu	37	1	1268156	1268156	+	Silent	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:1268156C>T	uc010nyk.1	+	3	1245	c.1245C>T	c.(1243-1245)TGC>TGT	p.C415C		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	415	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCTCAGGCTGCCCCGCGCAGG	0.657000													4	45					0	0	0.001984	0	0	
PLEKHM2	23207	broad.mit.edu	37	1	16059105	16059105	+	Splice_Site	SNP	A	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:16059105A>C	uc010obo.1	+	19	3033	c.2806_splice	c.e19-2	p.E936_splice		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M						Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GGCTCTCCCTAGGAGTTCTCC	0.622000													3	16					0	0	0.009096	0	0	
USP48	84196	broad.mit.edu	37	1	22030758	22030758	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:22030758G>A	uc001bfb.2	-	20	2750	c.2512C>T	c.(2512-2514)CCC>TCC	p.P838S	USP48_uc001bfa.2_Missense_Mutation_p.P376S|USP48_uc010odq.1_Missense_Mutation_p.P850S|USP48_uc009vqc.2_Missense_Mutation_p.P772S|USP48_uc001bfc.2_Missense_Mutation_p.P838S|USP48_uc001bfd.1_5'UTR	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	838					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		AACTTACTGGGCTCAGAAATA	0.353000													9	52					0	0	0.008291	0	0	
ARID1A	8289	broad.mit.edu	37	1	27097694	27097694	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:27097694C>T	uc001bmv.1	+	12	3656	c.3283C>T	c.(3283-3285)CAG>TAG	p.Q1095*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1095*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1095*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q712*|ARID1A_uc001bmx.1_5'UTR|ARID1A_uc009vsm.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1095	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTGAAAAAGCAGTATATCCA	0.483000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								8	61					0	0	0.006214	0	0	
LRRC7	57554	broad.mit.edu	37	1	70503977	70503977	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:70503977G>A	uc001dep.2	+	19	2386	c.2356G>A	c.(2356-2358)GCC>ACC	p.A786T	LRRC7_uc009wbg.2_Missense_Mutation_p.A70T|LRRC7_uc001deq.2_Missense_Mutation_p.A27T	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	786						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GGAAACCACAGCCGAGAATGC	0.493000													4	174					0	0	0.009096	0	0	
EXO1	9156	broad.mit.edu	37	1	242045261	242045261	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr1:242045261A>T	uc001hzh.2	+	14	2693	c.2153A>T	c.(2152-2154)CAG>CTG	p.Q718L	EXO1_uc001hzi.2_Missense_Mutation_p.Q718L|EXO1_uc001hzj.2_Missense_Mutation_p.Q718L|EXO1_uc009xgq.2_Missense_Mutation_p.Q717L	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	718	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			CAAAGTGACCAGACCTCCAAG	0.294000								Direct_reversal_of_damage|Editing_and_processing_nucleases					7	50					0	0	0.003080	0	0	
MYO3A	53904	broad.mit.edu	37	10	26482184	26482184	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr10:26482184C>T	uc001isn.2	+	32	4849	c.4489C>T	c.(4489-4491)CGG>TGG	p.R1497W	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1497					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AAGACGACCCCGGAAACCCAA	0.378000													6	36					0	0	0.003080	0	0	
LOC642826	642826	broad.mit.edu	37	10	47207813	47207813	+	RNA	SNP	T	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr10:47207813T>C	uc001jei.2	-	12		c.1586A>G			uc009xnf.2_Missense_Mutation_p.H132R					Homo sapiens cDNA, FLJ99065.												0						TTTACTTACATGGTTTGTACA	0.294000													5	27					0	0	0.014758	0	0	
PANK1	53354	broad.mit.edu	37	10	91371722	91371722	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr10:91371722C>A	uc001kgp.1	-	2	943	c.787G>T	c.(787-789)GAG>TAG	p.E263*	PANK1_uc001kgn.1_Nonsense_Mutation_p.E38*|PANK1_uc001kgo.1_Nonsense_Mutation_p.E38*|PANK1_uc009xtu.1_Nonsense_Mutation_p.E65*	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	263					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	TCCTCTTGCTCCTCTTCGGCT	0.468000													9	93					3.86212e-05	4.31893e-05	0.008291	1	0	
CTNND1	1500	broad.mit.edu	37	11	57575682	57575682	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr11:57575682C>A	uc001nmc.3	+	13	2580	c.2009C>A	c.(2008-2010)TCA>TAA	p.S670*	CTNND1_uc001nlh.1_Nonsense_Mutation_p.S670*|CTNND1_uc001nlu.3_Nonsense_Mutation_p.S563*|CTNND1_uc001nlt.3_Nonsense_Mutation_p.S563*|CTNND1_uc001nls.3_Nonsense_Mutation_p.S563*|CTNND1_uc001nlw.3_Nonsense_Mutation_p.S563*|CTNND1_uc001nmf.3_Nonsense_Mutation_p.S670*|CTNND1_uc001nmd.3_Nonsense_Mutation_p.S616*|CTNND1_uc001nlk.3_Nonsense_Mutation_p.S616*|CTNND1_uc001nme.3_Nonsense_Mutation_p.S664*|CTNND1_uc001nll.3_Nonsense_Mutation_p.S610*|CTNND1_uc001nmg.3_Nonsense_Mutation_p.S610*|CTNND1_uc001nlj.3_Nonsense_Mutation_p.S610*|CTNND1_uc001nlr.3_Nonsense_Mutation_p.S610*|CTNND1_uc001nlp.3_Nonsense_Mutation_p.S610*|CTNND1_uc001nlx.3_Nonsense_Mutation_p.S347*|CTNND1_uc001nlz.3_Nonsense_Mutation_p.S347*|CTNND1_uc009ymn.2_Nonsense_Mutation_p.S341*|CTNND1_uc001nlm.3_Nonsense_Mutation_p.S664*|CTNND1_uc001nly.3_Nonsense_Mutation_p.S341*|CTNND1_uc001nmb.3_Nonsense_Mutation_p.S341*|CTNND1_uc001nma.3_Nonsense_Mutation_p.S341*|CTNND1_uc001nmi.3_Nonsense_Mutation_p.S569*|CTNND1_uc001nmh.3_Nonsense_Mutation_p.S664*|CTNND1_uc001nlq.3_Nonsense_Mutation_p.S569*|CTNND1_uc001nln.3_Nonsense_Mutation_p.S664*|CTNND1_uc001nli.3_Nonsense_Mutation_p.S664*|CTNND1_uc001nlo.3_Nonsense_Mutation_p.S563*|CTNND1_uc001nlv.3_Nonsense_Mutation_p.S563*	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	670	ARM 7.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				ATATACATCTCACTTCTTAAG	0.483000													4	30					3.59834e-05	4.06768e-05	0.001168	1	0	
WNK1	65125	broad.mit.edu	37	12	939261	939261	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:939261G>A	uc001qio.3	+	4	1753	c.1246G>A	c.(1246-1248)GCT>ACT	p.A416T	WNK1_uc001qip.3_Missense_Mutation_p.A416T	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	416	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCTTGAGATGGCTACATCTGA	0.458000													13	56					0	0	0.003163	0	0	
CD163	9332	broad.mit.edu	37	12	7651576	7651576	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:7651576C>G	uc001qsz.3	-	4	794	c.666G>C	c.(664-666)TGG>TGC	p.W222C	CD163_uc001qta.3_Missense_Mutation_p.W222C|CD163_uc009zfw.2_Missense_Mutation_p.W222C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	222	SRCR 2.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GATCATCAAACCAGATTGGTC	0.428000													14	160					0	0	0.004007	0	0	
ADAMTS20	80070	broad.mit.edu	37	12	43771289	43771289	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:43771289T>G	uc010skx.1	-	32	4874	c.4874A>C	c.(4873-4875)AAG>ACG	p.K1625T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1625	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCGATGGAGCTTATGTTTCTT	0.403000													5	35					0	0	0.014758	0	0	
MON2	23041	broad.mit.edu	37	12	62943575	62943575	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:62943575G>C	uc001sre.2	+	23	3272	c.2881G>C	c.(2881-2883)GAA>CAA	p.E961Q	MON2_uc009zqj.2_Missense_Mutation_p.E961Q|MON2_uc010ssl.1_Missense_Mutation_p.E889Q|MON2_uc010ssm.1_Missense_Mutation_p.E938Q|MON2_uc010ssn.1_Missense_Mutation_p.E961Q|MON2_uc001srf.2_Missense_Mutation_p.E724Q	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	962					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CCATAACCAAGAACTCAATAT	0.343000													5	58					0	0	0.014758	0	0	
BTBD11	121551	broad.mit.edu	37	12	108010928	108010928	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:108010928G>A	uc001tmk.1	+	8	2585	c.2064G>A	c.(2062-2064)TCG>TCA	p.S688S	BTBD11_uc009zut.1_Silent_p.S688S|BTBD11_uc001tmj.2_Silent_p.S688S|BTBD11_uc001tml.1_Silent_p.S225S	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	688	ANK 3.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						AGAACTACTCGGAAACACCCC	0.617000													13	77					0	0	0.020292	0	0	
CCDC60	160777	broad.mit.edu	37	12	119926657	119926657	+	Silent	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:119926657C>T	uc001txe.2	+	5	1008	c.543C>T	c.(541-543)ACC>ACT	p.T181T	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	181										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CTGTGATCACCTGCTGGAACC	0.547000													19	92					0	0	0.014323	0	0	
HNF1A	6927	broad.mit.edu	37	12	121435302	121435302	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr12:121435302T>G	uc001tzg.2	+	7	1358	c.1335T>G	c.(1333-1335)AGT>AGG	p.S445R	HNF1A_uc001tzf.2_Missense_Mutation_p.S445R|HNF1A_uc010szn.1_Missense_Mutation_p.S445R	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	445					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGGCACAGAGTGTGCCGGTCA	0.662000									Hepatic_Adenoma_Familial_Clustering_of				3	39					0	0	0.014758	0	0	
FRY	10129	broad.mit.edu	37	13	32653026	32653026	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr13:32653026G>A	uc001utx.2	+	2	622	c.126G>A	c.(124-126)ACG>ACA	p.T42T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	42					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTCTGGCACGCACAGGGAGA	0.478000													4	275					0	0	0.014758	0	0	
SLITRK5	26050	broad.mit.edu	37	13	88328641	88328641	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr13:88328641G>A	uc001vln.2	+	2	1217	c.998G>A	c.(997-999)GGG>GAG	p.G333E	SLITRK5_uc010tic.1_Missense_Mutation_p.G92E	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	333	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCCCCTAAGGGGACTCGCCAA	0.587000													10	98					0	0	0.020292	0	0	
TEP1	7011	broad.mit.edu	37	14	20852247	20852247	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr14:20852247T>C	uc001vxe.2	-	24	3524	c.3484A>G	c.(3484-3486)AGG>GGG	p.R1162G	TEP1_uc010ahk.2_Missense_Mutation_p.R512G|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.R1054G|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1162	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGCTCAGCCTTCCGTGGGGC	0.652000													10	50					0	0	0.010729	0	0	
CLEC14A	161198	broad.mit.edu	37	14	38724436	38724436	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr14:38724436G>A	uc001wum.1	-	1	1139	c.792C>T	c.(790-792)GAC>GAT	p.D264D		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	264	Extracellular (Potential).|EGF-like.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CTCCCAAGTCGTCTAGGCAGT	0.637000													10	161					0	0	0.010729	0	0	
MIR329-1	574408	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr14:101493161A>T	hsa-mir-329-1|MI0001725	+			c.40A>T			MIR329-2_hsa-mir-329-2|MI0001726_5'Flank|MIR494_hsa-mir-494|MI0003134_5'Flank|uc010txm.1_5'Flank																	0						TGTTTCTTTAATGAGGACGAA	0.468000													5	94					0	0	0.014758	0	0	
HSP90AA1	3320	broad.mit.edu	37	14	102551035	102551035	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr14:102551035C>T	uc001yku.3	-	5	1154	c.964G>A	c.(964-966)GAT>AAT	p.D322N	HSP90AA1_uc001ykv.3_Missense_Mutation_p.D444N|HSP90AA1_uc001ykw.1_Missense_Mutation_p.D143N|HSP90AA1_uc001ykx.1_Missense_Mutation_p.D311N	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	322					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	GCCAAGTGATCTTCCCAGTCA	0.428000													10	135					0	0	0.013537	0	0	
AHNAK2	113146	broad.mit.edu	37	14	105415147	105415147	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr14:105415147G>A	uc010axc.1	-	7	6761	c.6641C>T	c.(6640-6642)GCT>GTT	p.A2214V	AHNAK2_uc001ypx.2_Missense_Mutation_p.A2114V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2214						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCTGGCCAGCCTGGACCTT	0.637000													10	105					0	0	0.008291	0	0	
ABCA3	21	broad.mit.edu	37	16	2326738	2326738	+	Silent	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr16:2326738C>T	uc002cpy.1	-	33	5764	c.5052G>A	c.(5050-5052)TCG>TCA	p.S1684S	ABCA3_uc010bsk.1_Silent_p.S1626S	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1684					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCTGTTCCAGCGAGATCTGGC	0.597000													3	63					0	0	0.004672	0	0	
ABCA3	21	broad.mit.edu	37	16	2331442	2331442	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr16:2331442G>A	uc002cpy.1	-	27	4816	c.4104C>T	c.(4102-4104)ATC>ATT	p.I1368I	ABCA3_uc010bsk.1_Silent_p.I1310I	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1368					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGGGGGCCAGGATGCGGGTCC	0.567000													6	89					0	0	0.003080	0	0	
BCL7C	9274	broad.mit.edu	37	16	30903924	30903924	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr16:30903924C>T	uc002dzv.2	-	4	559	c.425G>A	c.(424-426)CGG>CAG	p.R142Q	BCL7C_uc002dzt.1_Missense_Mutation_p.R142Q|uc002dzu.2_Intron|MIR762_hsa-mir-762|MI0003892_5'Flank	NM_004765	NP_004756	Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	142	Pro-rich.				apoptosis						0			Colorectal(24;0.198)			TTGGCCCAGCCGTGGGGGCTG	0.642000													4	25					0	0	0.014758	0	0	
ARMC5	79798	broad.mit.edu	37	16	31476027	31476027	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr16:31476027G>A	uc002ecc.2	+	4	2212	c.1683G>A	c.(1681-1683)CCG>CCA	p.P561P	ARMC5_uc010vfn.1_Silent_p.P656P|ARMC5_uc010vfo.1_Silent_p.P593P|ARMC5_uc002eca.3_Silent_p.P561P|ARMC5_uc010vfp.1_Silent_p.P369P|ARMC5_uc002ecb.2_Silent_p.P561P	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	561							binding			pancreas(1)	1						CACCGGGCCCGCCCAGCCCAC	0.701000													8	26					0	0	0.006214	0	0	
COX4I1	1327	broad.mit.edu	37	16	85839345	85839345	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr16:85839345G>A	uc002fje.2	+	4	412	c.248G>A	c.(247-249)CGC>CAC	p.R83H	COX4I1_uc002fjf.2_3'UTR|COX4I1_uc002fjg.1_Missense_Mutation_p.R83H|COX4I1_uc010vom.1_Missense_Mutation_p.R50H	NM_001861	NP_001852	P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	83					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			lung(1)	1		Renal(780;0.228)				CCAGTGTATCGCATTAAGTTC	0.537000													3	73					0	0	0.009096	0	0	
CAMKK1	84254	broad.mit.edu	37	17	3787704	3787704	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr17:3787704G>A	uc002fwt.2	-	3	472	c.378C>T	c.(376-378)AAC>AAT	p.N126N	CAMKK1_uc002fwu.2_Silent_p.N126N|CAMKK1_uc002fwv.2_Silent_p.N126N	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	126					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity	p.N126N(1)		ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		GCTTGTACTGGTTCAGCTGCA	0.612000													13	178					0	0	0.016723	0	0	
RNF167	26001	broad.mit.edu	37	17	4848302	4848302	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr17:4848302C>G	uc002fzq.2	+	11	1460	c.1044C>G	c.(1042-1044)ATC>ATG	p.I348M	RNF167_uc002fzr.2_Missense_Mutation_p.I348M|RNF167_uc002fzs.2_Missense_Mutation_p.I348M|RNF167_uc002fzt.2_Missense_Mutation_p.I348M|RNF167_uc002fzu.2_Missense_Mutation_p.I347M|RNF167_uc002fzv.2_Missense_Mutation_p.I313M|RNF167_uc002fzx.2_Missense_Mutation_p.I312M|RNF167_uc002fzy.2_Missense_Mutation_p.I147M	NM_015528	NP_056343	Q9H6Y7	RN167_HUMAN	ring finger protein 167 precursor	348					negative regulation of cell cycle|protein polyubiquitination	cytoplasm|endomembrane system|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						CCCCTGTTATCCTGGTCTAAT	0.552000													11	188					0	0	0.016723	0	0	
CCR7	1236	broad.mit.edu	37	17	38711207	38711207	+	Silent	SNP	G	A	A	rs116263918	byFrequency	TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr17:38711207G>A	uc002huw.2	-	3	987	c.924C>T	c.(922-924)TAC>TAT	p.Y308Y		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	308	Extracellular (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				AGGTGACGTCGTAGGCGATGT	0.567000													15	50					0	0	0.004990	0	0	
BCAS3	54828	broad.mit.edu	37	17	59155713	59155713	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr17:59155713C>T	uc002iyv.3	+	22	2304	c.2195C>T	c.(2194-2196)ACT>ATT	p.T732I	BCAS3_uc002iyu.3_Missense_Mutation_p.T717I|BCAS3_uc002iyw.3_Missense_Mutation_p.T713I|BCAS3_uc002iyy.3_Missense_Mutation_p.T488I|BCAS3_uc002iyz.3_Missense_Mutation_p.T286I|BCAS3_uc002iza.3_Missense_Mutation_p.T271I	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	732						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GTAACACACACTGGACCCCAT	0.443000													13	45					0	0	0.003163	0	0	
MIB1	57534	broad.mit.edu	37	18	19444574	19444574	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr18:19444574A>T	uc002ktq.2	+	21	2968	c.2968A>T	c.(2968-2970)AGT>TGT	p.S990C	MIB1_uc002ktp.2_Missense_Mutation_p.S629C	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	990	RING-type 3.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			AGACCGCATGAGTGAATGTCC	0.408000													14	108					0	0	0.004990	0	0	
FHOD3	80206	broad.mit.edu	37	18	34340633	34340633	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr18:34340633G>A	uc002kzt.1	+	22	4009	c.3912G>A	c.(3910-3912)GCG>GCA	p.A1304A	FHOD3_uc002kzs.1_Silent_p.A1321A|FHOD3_uc010dmz.1_Silent_p.A1036A|FHOD3_uc010dnb.1_Intron	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1304					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TGAGCTATGCGGAGGACGCGG	0.652000													10	61					0	0	0.006214	0	0	
UHRF1	29128	broad.mit.edu	37	19	4929291	4929291	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:4929291C>A	uc002mbo.2	+	3	379	c.211C>A	c.(211-213)CTC>ATC	p.L71I	UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.L84I	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	71	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CACCATCCAGCTCCTGGTCCG	0.637000													7	68					0.000157383	0.000170499	0.003080	1	0	
DHPS	1725	broad.mit.edu	37	19	12790510	12790510	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:12790510T>A	uc002muh.1	-	4	615	c.518A>T	c.(517-519)AAT>ATT	p.N173I	DHPS_uc002muf.1_Missense_Mutation_p.N50I|DHPS_uc002mug.1_Missense_Mutation_p.N131I|DHPS_uc002mui.1_Missense_Mutation_p.N173I|DHPS_uc002muj.1_Missense_Mutation_p.N173I|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	173					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	GTAATTCTCATTGGGCACCAG	0.592000													38	155					0	0	0.008740	0	0	
ZNF737	100129842	broad.mit.edu	37	19	20728254	20728254	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:20728254C>G	uc002npa.2	-	4	935	c.755G>C	c.(754-756)AGT>ACT	p.S252T		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	252					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTTCTCTCCACTATGAATTAT	0.403000													3	40					0	0	0.004672	0	0	
ZNF626	199777	broad.mit.edu	37	19	20807184	20807184	+	Missense_Mutation	SNP	T	C	C	rs71332197		TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:20807184T>C	uc002npb.1	-	4	1649	c.1499A>G	c.(1498-1500)GAG>GGG	p.E500G	ZNF626_uc002npc.1_Missense_Mutation_p.E424G	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	500	C2H2-type 12; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TATGATTCTCTCATGTGTAGT	0.398000													3	103					0	0	0.004672	0	0	
CYP2S1	29785	broad.mit.edu	37	19	41700606	41700606	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:41700606A>T	uc002opw.2	+	2	390	c.335A>T	c.(334-336)GAT>GTT	p.D112V	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Missense_Mutation_p.M1L	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	112					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						GGGACTTTTGATGGCCATGGT	0.473000													4	53					0	0	0.014758	0	0	
CEACAM5	1048	broad.mit.edu	37	19	42219758	42219758	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:42219758C>T	uc002ork.2	+	4	1014	c.893C>T	c.(892-894)ACG>ATG	p.T298M	CEACAM5_uc010ehz.1_3'UTR|CEACAM5_uc002orj.1_Missense_Mutation_p.T298M|CEACAM5_uc002orl.2_Missense_Mutation_p.T298M	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	298	Ig-like 3.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GGATCCTATACGTGCCAAGCC	0.473000													25	88					0	0	0.021523	0	0	
ZNF221	7638	broad.mit.edu	37	19	44470470	44470470	+	Silent	SNP	T	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:44470470T>C	uc002oxx.2	+	6	1144	c.816T>C	c.(814-816)CAT>CAC	p.H272H	ZNF221_uc010ejb.1_Silent_p.H272H|ZNF221_uc010xws.1_Silent_p.H272H	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	272	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				TTAATGTTCATTGCAAATTGC	0.413000													33	182					0	0	0.019004	0	0	
MYBPC2	4606	broad.mit.edu	37	19	50958504	50958504	+	Silent	SNP	T	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:50958504T>C	uc002psf.2	+	19	2205	c.2154T>C	c.(2152-2154)GCT>GCC	p.A718A		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	718	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCGTCAATGCTATAGGGGTCT	0.483000													33	185					0	0	0.009718	0	0	
C2orf86	51057	broad.mit.edu	37	2	63631623	63631623	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:63631623G>C	uc002sch.2	-	10	1441	c.995C>G	c.(994-996)ACC>AGC	p.T332S	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.T173S|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.T140S|C2orf86_uc002sci.1_Missense_Mutation_p.T308S|C2orf86_uc010fcr.1_Missense_Mutation_p.T222S	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	332	WD 1.				cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TGGTATTCTGGTGACTGACAC	0.443000													7	120					0	0	0.003080	0	0	
TUBA3E	112714	broad.mit.edu	37	2	130951688	130951688	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:130951688G>A	uc002tqv.2	-	4	828	c.727C>T	c.(727-729)CGA>TGA	p.R243*		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	243					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CCATCAAATCGCAGGGAGGCC	0.582000													23	151					0	0	0.005443	0	0	
FAM123C	205147	broad.mit.edu	37	2	131520836	131520836	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:131520836G>C	uc002trw.2	+	2	1381	c.1191G>C	c.(1189-1191)GAG>GAC	p.E397D	FAM123C_uc010fmv.2_Missense_Mutation_p.E397D|FAM123C_uc010fms.1_Missense_Mutation_p.E397D|FAM123C_uc010fmt.1_Missense_Mutation_p.E397D|FAM123C_uc010fmu.1_Missense_Mutation_p.E397D	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	397										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GACTTGAGGAGGACAAGAAGG	0.622000													12	50					0	0	0.016723	0	0	
RAPGEF4	11069	broad.mit.edu	37	2	173898667	173898667	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:173898667T>A	uc002uhv.3	+	27	2862	c.2675T>A	c.(2674-2676)TTC>TAC	p.F892Y	RAPGEF4_uc002uhw.3_Missense_Mutation_p.F748Y	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	892	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTCAAGAAGTTCTATGCGGAG	0.348000													13	59					0	0	0.004990	0	0	
VWC2L	402117	broad.mit.edu	37	2	215278974	215278974	+	Silent	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:215278974C>T	uc002vet.2	+	2	187	c.57C>T	c.(55-57)GTC>GTT	p.V19V	VWC2L_uc010zjl.1_Silent_p.V19V	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	19						extracellular region					0						CTGGATTGGTCACCTCTGCTG	0.433000													6	93					0	0	0.003080	0	0	
ARPC2	10109	broad.mit.edu	37	2	219110154	219110154	+	Silent	SNP	A	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr2:219110154A>G	uc002vhd.2	+	8	673	c.561A>G	c.(559-561)GAA>GAG	p.E187E	ARPC2_uc002vhe.2_Silent_p.E187E|ARPC2_uc002vhf.2_Silent_p.E73E	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	187					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		AGTTCAAAGAAGGACGCAGAG	0.517000													10	120					0	0	0.008291	0	0	
ELMO2	63916	broad.mit.edu	37	20	45003173	45003173	+	Splice_Site	SNP	A	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr20:45003173A>T	uc002xrt.1	-	14	1380	c.1170_splice	c.e14+1	p.R390_splice	ELMO2_uc010zxq.1_Splice_Site_p.R122_splice|ELMO2_uc002xrs.1_Splice_Site_p.R137_splice|ELMO2_uc002xru.1_Splice_Site_p.R390_splice|ELMO2_uc010zxr.1_Splice_Site_p.R402_splice|ELMO2_uc010zxs.1_Splice_Site_p.R207_splice|ELMO2_uc002xrv.1_Splice_Site_p.R109_splice|ELMO2_uc002xrw.2_Splice_Site_p.R207_splice	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2						apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCCTGCCTTTACCCGGATGTA	0.542000													4	71					0	0	0.014758	0	0	
SNAI1	6615	broad.mit.edu	37	20	48600433	48600433	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr20:48600433C>G	uc002xuz.2	+	2	225	c.155C>G	c.(154-156)CCC>CGC	p.P52R		NM_005985	NP_005976	O95863	SNAI1_HUMAN	snail 1 homolog	52					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			ATCCTCAACCCCACCGCCTCG	0.637000													5	122					0	0	0.001168	0	0	
MOCS3	27304	broad.mit.edu	37	20	49576176	49576176	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr20:49576176G>T	uc002xvy.1	+	1	814	c.797G>T	c.(796-798)GGT>GTT	p.G266V	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	266					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						ATCGCTGCGGGTCTGGGCCCC	0.637000													6	66					0.00116845	0.00123998	0.001168	1	0	
SON	6651	broad.mit.edu	37	21	34918589	34918589	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr21:34918589G>A	uc002yse.1	+	2	197	c.148G>A	c.(148-150)GCT>ACT	p.A50T	SON_uc002ysb.1_Missense_Mutation_p.A50T|SON_uc002ysc.2_Missense_Mutation_p.A50T|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Missense_Mutation_p.A50T	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	50					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GGGTGATGCAGCTGCCTCTGC	0.428000													3	77					0	0	0.009096	0	0	
DYRK1A	1859	broad.mit.edu	37	21	38877823	38877823	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr21:38877823G>A	uc002ywk.2	+	9	1552	c.1477G>A	c.(1477-1479)GTA>ATA	p.V493I	DYRK1A_uc002ywi.2_Missense_Mutation_p.V493I|DYRK1A_uc002ywj.2_Missense_Mutation_p.V484I|DYRK1A_uc002ywl.2_Missense_Mutation_p.V493I|DYRK1A_uc002ywm.2_Missense_Mutation_p.V493I|DYRK1A_uc011aei.1_Missense_Mutation_p.V254I	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	493					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						AAGTAATAGTGTATCTACAAG	0.468000													20	143					0	0	0.018920	0	0	
NIPSNAP1	8508	broad.mit.edu	37	22	29956772	29956772	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr22:29956772G>A	uc003afx.3	-	8	730	c.657C>T	c.(655-657)GGC>GGT	p.G219G	NIPSNAP1_uc011akp.1_Silent_p.G199G	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1	219								p.?(1)		skin(1)	1						AGAAGAAGCCGCCCACTGCCT	0.557000													19	183					0	0	0.005443	0	0	
PKDREJ	10343	broad.mit.edu	37	22	46657925	46657925	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr22:46657925C>G	uc003bhh.2	-	1	1295	c.1295G>C	c.(1294-1296)AGA>ACA	p.R432T		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	432	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AATCACCATTCTGAAGAAATA	0.502000													8	78					0	0	0.008291	0	0	
MYRIP	25924	broad.mit.edu	37	3	40251427	40251427	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:40251427G>A	uc003cka.2	+	11	1883	c.1748G>A	c.(1747-1749)CGG>CAG	p.R583Q	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.R583Q|MYRIP_uc010hhw.2_Missense_Mutation_p.R494Q|MYRIP_uc011ayz.1_Missense_Mutation_p.R396Q|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	583	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GAGGAGAAACGGAGAAACAGG	0.478000													5	71					0	0	0.014758	0	0	
ZPLD1	131368	broad.mit.edu	37	3	102171950	102171950	+	Silent	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:102171950C>A	uc003dvs.1	+	10	1176	c.294C>A	c.(292-294)CTC>CTA	p.L98L	ZPLD1_uc003dvt.1_Silent_p.L114L|ZPLD1_uc011bhg.1_Silent_p.L98L	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	98	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						TCATCAATCTCAGCACCTTGG	0.448000													3	65					0.00024832	0.00026624	0.009096	1	0	
MYLK	4638	broad.mit.edu	37	3	123419688	123419688	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:123419688C>T	uc003ego.2	-	18	2909	c.2627G>A	c.(2626-2628)CGC>CAC	p.R876H	MYLK_uc011bjw.1_Missense_Mutation_p.R876H|MYLK_uc003egp.2_Missense_Mutation_p.R807H|MYLK_uc003egq.2_Missense_Mutation_p.R876H|MYLK_uc003egr.2_Missense_Mutation_p.R807H|MYLK_uc003egs.2_Missense_Mutation_p.R700H|MYLK_uc003egt.2_Missense_Mutation_p.R67H	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	876	5 X 28 AA approximate tandem repeats.|1-1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CGTCTCCACGCGCCTCTTCAG	0.642000													26	95					0	0	0.013726	0	0	
PIK3CA	5290	broad.mit.edu	37	3	178921553	178921553	+	Missense_Mutation	SNP	T	A	A	rs121913284		TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:178921553T>A	uc003fjk.2	+	5	1192	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(29)|p.N345I(2)|p.N345S(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTACGTGAATGTAAATATTC	0.308000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	72					0	0	0.020292	0	0	
LEPREL1	55214	broad.mit.edu	37	3	189690711	189690711	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:189690711T>G	uc011bsk.1	-	11	2039	c.1651A>C	c.(1651-1653)ACT>CCT	p.T551P	LEPREL1_uc003fsg.2_Missense_Mutation_p.T370P	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	551					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAATACAGAGTTGAGTTCAGC	0.433000													17	53					0	0	0.010504	0	0	
BDH1	622	broad.mit.edu	37	3	197238850	197238850	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr3:197238850G>A	uc003fxr.2	-	8	1350	c.948C>T	c.(946-948)CAC>CAT	p.H316H	BDH1_uc003fxs.2_Silent_p.H316H|BDH1_uc003fxt.2_Silent_p.H229H|BDH1_uc003fxu.2_Silent_p.H316H	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	316					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	AGTCCATGGGGTGGTAGCGGG	0.592000													53	166					0	0	0.014410	0	0	
GABRA2	2555	broad.mit.edu	37	4	46264078	46264078	+	Silent	SNP	A	G	G	rs35058221	byFrequency	TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:46264078A>G	uc003gxc.3	-	8	1597	c.924T>C	c.(922-924)GCT>GCC	p.A308A	GABRA2_uc010igc.2_Silent_p.A308A|GABRA2_uc011bzc.1_Silent_p.A253A|GABRA2_uc003gxe.2_Silent_p.A308A	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	308					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGTTGCATAAGCCACTTTGG	0.393000													9	104					0	0	0.008291	0	0	
PPAT	5471	broad.mit.edu	37	4	57301585	57301585	+	Nonsense_Mutation	SNP	G	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:57301585G>C	uc003hbr.2	-	1	261	c.59C>G	c.(58-60)TCA>TGA	p.S20*	PAICS_uc003hbs.1_5'Flank|PAICS_uc011cac.1_5'Flank|PAICS_uc003hbt.1_5'Flank|PAICS_uc003hbu.1_5'Flank|PAICS_uc010ihd.1_5'Flank	NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	20	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	CCACTCTCCTGAGGCGATGCA	0.662000													23	142					0	0	0.014323	0	0	
TRPC3	7222	broad.mit.edu	37	4	122801003	122801003	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:122801003G>T	uc003ieg.2	-	12	2728	c.2654C>A	c.(2653-2655)TCC>TAC	p.S885Y	TRPC3_uc010inr.2_Missense_Mutation_p.S757Y|TRPC3_uc003ief.2_Missense_Mutation_p.S812Y|TRPC3_uc011cgl.1_Missense_Mutation_p.S549Y	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	800	Extracellular (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ACGAAGGCTGGAGATATCTTG	0.333000													7	58					3.09899e-07	3.5417e-07	0.004482	1	0	
LRBA	987	broad.mit.edu	37	4	151836804	151836804	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:151836804G>A	uc010ipj.2	-	8	1444	c.970C>T	c.(970-972)CTG>TTG	p.L324L	LRBA_uc003ilu.3_Silent_p.L324L|LRBA_uc010ipk.1_Silent_p.L243L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	324						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TAGGAAGCCAGCTCACCATTC	0.353000													3	51					0	0	0.009096	0	0	
PLRG1	5356	broad.mit.edu	37	4	155461124	155461124	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:155461124C>A	uc003iny.2	-	11	1084	c.1021G>T	c.(1021-1023)GCA>TCA	p.A341S	PLRG1_uc003inz.2_Missense_Mutation_p.A332S	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	341	WD 4.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				TGTGGTTCTGCAGCCTGACAT	0.333000													19	122					7.16444e-05	7.84318e-05	0.021523	1	0	
GUCY1A3	2982	broad.mit.edu	37	4	156638314	156638314	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:156638314G>A	uc003iov.2	+	9	2112	c.1576G>A	c.(1576-1578)GAG>AAG	p.E526K	GUCY1A3_uc010iqc.2_Missense_Mutation_p.E526K|GUCY1A3_uc003iow.2_Missense_Mutation_p.E526K|GUCY1A3_uc010iqd.2_Missense_Mutation_p.E525K|GUCY1A3_uc003iox.2_Missense_Mutation_p.E526K|GUCY1A3_uc003ioz.2_Missense_Mutation_p.E291K|GUCY1A3_uc003ioy.2_Missense_Mutation_p.E526K|GUCY1A3_uc010iqe.2_Missense_Mutation_p.E291K|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.E526K	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	526	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGTCTAGGTGGAGACCATTGG	0.408000													17	98					0	0	0.018920	0	0	
TRIML2	205860	broad.mit.edu	37	4	189012674	189012674	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr4:189012674C>A	uc003izl.2	-	7	1053	c.1017G>T	c.(1015-1017)ATG>ATT	p.M339I	TRIML2_uc003izj.1_Missense_Mutation_p.M167I|TRIML2_uc003izk.1_Missense_Mutation_p.M147I|TRIML2_uc011cle.1_Missense_Mutation_p.M414I	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	339	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AAATGAGGGACATCTCGGTCA	0.493000													9	123					1.08611e-07	1.25506e-07	0.010729	1	0	
PTGER4	5734	broad.mit.edu	37	5	40692250	40692250	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr5:40692250A>C	uc003jlz.2	+	3	1829	c.1237A>C	c.(1237-1239)AAT>CAT	p.N413H		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	413	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TGGAGGCAGGAATTTGCTTCC	0.557000													16	49					0	0	0.004007	0	0	
HCN1	348980	broad.mit.edu	37	5	45695943	45695943	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr5:45695943C>A	uc003jok.2	-	1	278	c.253G>T	c.(253-255)GAG>TAG	p.E85*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	85	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CGGGGCCCCTCGGCGTCTTCG	0.502000													5	29					1.024e-07	1.19658e-07	0.014758	1	0	
IPO11	51194	broad.mit.edu	37	5	61857028	61857028	+	Silent	SNP	T	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr5:61857028T>A	uc003jtc.2	+	27	2716	c.2526T>A	c.(2524-2526)CCT>CCA	p.P842P	IPO11_uc011cqr.1_Silent_p.P882P|IPO11_uc003jtd.1_RNA|IPO11_uc010iwr.2_Silent_p.P107P	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	842	HEAT 13.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TTACCCAGCCTGAAAGAAGAA	0.383000													11	30					0	0	0.010729	0	0	
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348000													6	26					6.40141e-05	7.08241e-05	0.010729	1	0	
TTBK1	84630	broad.mit.edu	37	6	43251528	43251528	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:43251528G>A	uc003ouq.1	+	14	3329	c.3050G>A	c.(3049-3051)GGC>GAC	p.G1017D		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1017						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CTGCCCAATGGCCCGGCCCTT	0.667000													10	59					0	0	0.013537	0	0	
LRRC1	55227	broad.mit.edu	37	6	53785539	53785539	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:53785539G>A	uc003pcd.1	+	13	1673	c.1396G>A	c.(1396-1398)GAT>AAT	p.D466N		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	466						cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GGATGAGAAAGATGAAGAAGA	0.418000													8	58					0	0	0.006214	0	0	
PRDM1	639	broad.mit.edu	37	6	106553508	106553508	+	Silent	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:106553508G>A	uc003prd.2	+	5	1707	c.1473G>A	c.(1471-1473)GCG>GCA	p.A491A	PRDM1_uc003pre.2_Silent_p.A357A	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	491					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TTGTCCCGGCGCCCCACAGTG	0.682000			D|N|Mis|F|S		DLBCL								9	48					0	0	0.008291	0	0	
ROS1	6098	broad.mit.edu	37	6	117641088	117641088	+	Silent	SNP	T	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:117641088T>C	uc003pxp.1	-	36	6082	c.5883A>G	c.(5881-5883)GAA>GAG	p.E1961E	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Silent_p.E287E	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1961	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTGCTGTTCCTTCATACACTT	0.448000			T	GOPC|ROS1	glioblastoma|NSCLC								10	111					0	0	0.016723	0	0	
ESR1	2099	broad.mit.edu	37	6	152420094	152420094	+	Missense_Mutation	SNP	C	T	T	rs138891155	byFrequency	TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:152420094C>T	uc003qom.3	+	10	2151	c.1781C>T	c.(1780-1782)ACG>ATG	p.T594M	ESR1_uc010kin.2_Missense_Mutation_p.T594M|ESR1_uc010kio.2_Missense_Mutation_p.T596M|ESR1_uc010kip.2_Missense_Mutation_p.T593M|ESR1_uc003qon.3_Missense_Mutation_p.T594M|ESR1_uc003qoo.3_Missense_Mutation_p.T594M|ESR1_uc010kiq.2_Missense_Mutation_p.T192M|ESR1_uc010kir.2_Missense_Mutation_p.T333M|ESR1_uc011eet.1_RNA|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Missense_Mutation_p.T179M|ESR1_uc011eew.1_3'UTR|ESR1_uc011eex.1_Missense_Mutation_p.T269M|ESR1_uc011eey.1_3'UTR	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	594	Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	TTCCCTGCCACGGTCTGAGAG	0.537000													11	33					0	0	0.016723	0	0	
FNDC1	84624	broad.mit.edu	37	6	159636057	159636057	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr6:159636057C>T	uc010kjv.2	+	5	741	c.541C>T	c.(541-543)CGC>TGC	p.R181C	FNDC1_uc010kjw.1_Missense_Mutation_p.R129C	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	181	Fibronectin type-III 2.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAAGGCACCACGCCTGTCTGG	0.562000													8	66					0	0	0.004482	0	0	
ZMIZ2	83637	broad.mit.edu	37	7	44797586	44797586	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr7:44797586C>G	uc003tlr.2	+	6	815	c.692C>G	c.(691-693)CCC>CGC	p.P231R	ZMIZ2_uc003tlq.2_Missense_Mutation_p.P199R|ZMIZ2_uc003tls.2_Missense_Mutation_p.P231R|ZMIZ2_uc003tlt.2_5'Flank|ZMIZ2_uc010kyj.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	231	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						GCTATGAACCCCACCCGGGCA	0.667000													4	73					0	0	0.001168	0	0	
OR2F2	135948	broad.mit.edu	37	7	143632812	143632812	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr7:143632812A>C	uc011ktv.1	+	1	487	c.487A>C	c.(487-489)ACC>CCC	p.T163P		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GACTGCTATCACCTTTCAGCT	0.522000													6	114					0	0	0.004482	0	0	
RPL23AP53	644128	broad.mit.edu	37	8	163401	163401	+	RNA	SNP	G	C	C			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr8:163401G>C	uc010lra.2	-	4		c.732C>G			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						TCTGGTGCTTGTTGGCTTTAA	0.463000													3	34					0	0	0.009096	0	0	
MYC	4609	broad.mit.edu	37	8	128753034	128753034	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr8:128753034T>G	uc003ysi.2	+	3	1720	c.1195T>G	c.(1195-1197)TTG>GTG	p.L399V		NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	384	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GATCCCGGAGTTGGAAAACAA	0.498000		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL								7	185					0	0	0.003080	0	0	
C9orf93	203238	broad.mit.edu	37	9	15920398	15920398	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr9:15920398G>A	uc003zmd.2	+	25	4046	c.3731G>A	c.(3730-3732)CGT>CAT	p.R1244H	C9orf93_uc003zme.2_Missense_Mutation_p.R1159H|C9orf93_uc011lmu.1_Missense_Mutation_p.R1252H	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1244											0				GBM - Glioblastoma multiforme(50;4.84e-07)		GCTTGTTTACGTGAAAATGCA	0.328000													10	83					0	0	0.010729	0	0	
PPP6C	5537	broad.mit.edu	37	9	127920613	127920613	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr9:127920613G>A	uc004bpg.3	-	4	507	c.286C>T	c.(286-288)CTT>TTT	p.L96F	PPP6C_uc010mwv.2_Missense_Mutation_p.L133F|PPP6C_uc010mww.2_Missense_Mutation_p.L74F|PPP6C_uc011lzr.1_Intron	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	96					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						AATGCAAGAAGGTAAGTGAAG	0.358000													17	144					0	0	0.007413	0	0	
BCOR	54880	broad.mit.edu	37	X	39923604	39923604	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chrX:39923604G>A	uc004den.3	-	7	3779	c.3487C>T	c.(3487-3489)CGA>TGA	p.R1163*	BCOR_uc004dep.3_Nonsense_Mutation_p.R1163*|BCOR_uc004deo.3_Nonsense_Mutation_p.R1145*|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Nonsense_Mutation_p.R1163*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1163					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GAGACTCGTCGGCGTTTGGCT	0.627000													11	29					0	0	0.010729	0	0	
ZBTB33	10009	broad.mit.edu	37	X	119389023	119389023	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chrX:119389023C>G	uc004esn.1	+	2	1981	c.1753C>G	c.(1753-1755)CGT>GGT	p.R585G	ZBTB33_uc010nqm.1_Missense_Mutation_p.R585G	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	585	Interaction with CTNND1 (By similarity).|Required for DNA-binding (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAAGCTTTATCGTTTACATCC	0.378000													5	55					0	0	0.014758	0	0	
SBNO2	22904	broad.mit.edu	37	19	1119967	1119967	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-7196-01A-11D-2053-08	TCGA-BR-7196-10A-01D-2053-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd3a3c08-528b-44e9-bd44-1b6c48248baa	8627b3c5-c183-425c-96a0-c86a4ac4de83	g.chr19:1119967delT	uc002lrk.3	-	12	1443	c.1205delA	c.(1204-1206)AAGfs	p.K402fs	SBNO2_uc002lrj.3_Frame_Shift_Del_p.K345fs|SBNO2_uc010dse.2_Frame_Shift_Del_p.K395fs|SBNO2_uc010xgj.1_Frame_Shift_Del_p.K345fs|SBNO2_uc010dsf.2_Frame_Shift_Del_p.K345fs	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	402					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCACAGCCTTGCCCATCTT	0.627													2	4	---	---	---	---						.
