Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
PRAMEF4	400735	broad.mit.edu	37	1	12942129	12942129	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:12942129G>A	uc001aun.2	-	3	492	c.421C>T	c.(421-423)CCA>TCA	p.P141S		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	141										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTCATCCTTGGACAGTCCTCC	0.502000													34	283					0	0	0.004289	0	0	
DMAP1	55929	broad.mit.edu	37	1	44684864	44684864	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:44684864G>A	uc001clq.1	+	7	937	c.857G>A	c.(856-858)CGC>CAC	p.R286H	DMAP1_uc001clr.1_Missense_Mutation_p.R286H|DMAP1_uc001cls.1_Missense_Mutation_p.R286H|DMAP1_uc010oku.1_Missense_Mutation_p.R276H	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	286					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CGCACGGAACGCAAGGCCCCC	0.612000													6	53					0	0	0.001984	0	0	
LRRIQ3	127255	broad.mit.edu	37	1	74621486	74621486	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:74621486A>G	uc001dfy.3	-	4	830	c.638T>C	c.(637-639)CTG>CCG	p.L213P	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	213										ovary(2)	2						ATTATGAGCCAGAATTGCATT	0.244000													4	18					0	0	0.000602	0	0	
DRAM2	128338	broad.mit.edu	37	1	111663184	111663184	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:111663184C>G	uc001ead.3	-	6	728	c.471G>C	c.(469-471)TGG>TGC	p.W157C	DRAM2_uc001eae.3_Missense_Mutation_p.W157C|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_Missense_Mutation_p.W27C	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	157					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0						ACAGTCTGATCCAGAAGACTT	0.423000													3	52					0	0	0.004672	0	0	
FLG	2312	broad.mit.edu	37	1	152284662	152284662	+	Silent	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:152284662T>C	uc001ezu.1	-	3	2736	c.2700A>G	c.(2698-2700)GAA>GAG	p.E900E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	900	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTTGATTGTTCCTCATTAC	0.562000									Ichthyosis				37	689					0	0	0.005524	0	0	
LCE2C	353140	broad.mit.edu	37	1	152648577	152648577	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:152648577C>G	uc001fah.2	+	2	141	c.86C>G	c.(85-87)CCC>CGC	p.P29R		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	29	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			cctaagtgtccccccaaATGC	0.438000													26	241					0	0	0.005443	0	0	
FCRL2	79368	broad.mit.edu	37	1	157739893	157739893	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:157739893C>T	uc001fre.2	-	4	417	c.358G>A	c.(358-360)GAA>AAA	p.E120K	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.E120K|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Missense_Mutation_p.E120K	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	120	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGACCCCCTTCGATGGGCTGG	0.532000													5	87					0	0	0.001984	0	0	
ADAMTS4	9507	broad.mit.edu	37	1	161166028	161166028	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:161166028C>T	uc001fyt.3	-	3	1451	c.1023G>A	c.(1021-1023)CCG>CCA	p.P341P	ADAMTS4_uc001fyu.2_3'UTR	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	341	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGCTCCGAGCCGGGTCACAGA	0.562000													30	38					0	0	0.012213	0	0	
PAPPA2	60676	broad.mit.edu	37	1	176668713	176668713	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:176668713A>C	uc001gkz.2	+	8	4388	c.3224A>C	c.(3223-3225)AAG>ACG	p.K1075T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1075					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCTCACAGGAAGTTCACGGAC	0.537000													25	269					0	0	0.009535	0	0	
B3GALT2	8707	broad.mit.edu	37	1	193150565	193150565	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:193150565A>T	uc001gtc.3	-	2	843	c.128T>A	c.(127-129)TTC>TAC	p.F43Y	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	43	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1						ATGATGATTGAAAAACAAAAA	0.418000													10	78					0	0	0.006214	0	0	
KCNT2	343450	broad.mit.edu	37	1	196250003	196250003	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:196250003A>G	uc001gtd.1	-	25	2957	c.2897T>C	c.(2896-2898)CTT>CCT	p.L966P	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.L892P|KCNT2_uc001gtf.1_Missense_Mutation_p.L942P|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.L942P|KCNT2_uc001gth.1_Missense_Mutation_p.L463P	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	966	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AGATGTAGTAAGTTTCTGAGA	0.328000													9	64					0	0	0.008291	0	0	
ZNF281	23528	broad.mit.edu	37	1	200377112	200377112	+	Silent	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:200377112A>C	uc001gve.2	-	2	1829	c.1722T>G	c.(1720-1722)GTT>GTG	p.V574V	ZNF281_uc001gvf.1_Silent_p.V574V|ZNF281_uc001gvg.1_Silent_p.V538V	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	574					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CATTGTCCAAAACACTGACAC	0.423000													6	42					0	0	0.001168	0	0	
CR1	1378	broad.mit.edu	37	1	207684998	207684998	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:207684998C>G	uc001hfy.2	+	4	626	c.486C>G	c.(484-486)GAC>GAG	p.D162E	CR1_uc009xcl.1_Missense_Mutation_p.D162E|CR1_uc001hfx.2_Missense_Mutation_p.D162E|CR1_uc009xcj.1_Missense_Mutation_p.D162E|CR1_uc009xck.1_Missense_Mutation_p.D162E	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	162	Extracellular (Potential).|Sushi 2.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CTATTTGTGACAGtgagttga	0.214000													9	65					0	0	0.004482	0	0	
LIN9	286826	broad.mit.edu	37	1	226475499	226475499	+	Splice_Site	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:226475499C>T	uc001hqa.2	-	5	623	c.313_splice	c.e5-1	p.K105_splice	LIN9_uc001hqb.2_Splice_Site_p.K70_splice|LIN9_uc001hqc.2_Splice_Site_p.K37_splice|LIN9_uc009xel.1_Splice_Site_p.K70_splice	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog						cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CTGTAAATTTCTATACAATAA	0.294000													9	71					0	0	0.006214	0	0	
ACTA1	58	broad.mit.edu	37	1	229568156	229568156	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:229568156G>A	uc001htm.2	-	4	582	c.477C>T	c.(475-477)GAC>GAT	p.D159D		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	159					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GGGTGACGCCGTCGCCGGAGT	0.637000													6	56					0	0	0.001984	0	0	
ACTN2	88	broad.mit.edu	37	1	236902755	236902755	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:236902755A>G	uc001hyf.2	+	10	1234	c.1030A>G	c.(1030-1032)AAC>GAC	p.N344D	ACTN2_uc001hyg.2_Missense_Mutation_p.N136D|ACTN2_uc009xgi.1_Missense_Mutation_p.N344D|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_Missense_Mutation_p.N32D	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	344	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCTGGAGATCAACTTCAACAC	0.582000													9	110					0	0	0.010729	0	0	
ACTN2	88	broad.mit.edu	37	1	236910982	236910982	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:236910982C>T	uc001hyf.2	+	13	1626	c.1422C>T	c.(1420-1422)CAC>CAT	p.H474H	ACTN2_uc001hyg.2_Silent_p.H266H|ACTN2_uc009xgi.1_Silent_p.H474H|ACTN2_uc010pxu.1_Silent_p.H163H|ACTN2_uc001hyh.2_Silent_p.H162H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	474	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGGACTATCACGACGCTGTGA	0.408000													4	40					0	0	0.000602	0	0	
TRIM58	25893	broad.mit.edu	37	1	248020713	248020713	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr1:248020713C>T	uc001ido.2	+	1	213	c.165C>T	c.(163-165)TAC>TAT	p.Y55Y		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	55	RING-type.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCGGCGTCTACGCCTGTCCGC	0.701000													5	13					0	0	0.001168	0	0	
KIAA1462	57608	broad.mit.edu	37	10	30318221	30318221	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr10:30318221G>A	uc001iux.2	-	2	915	c.856C>T	c.(856-858)CGG>TGG	p.R286W	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.R148W|KIAA1462_uc009xle.1_Missense_Mutation_p.R286W	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	286	Pro-rich.									ovary(4)	4						AACTTAGGCCGGGGAAATGGG	0.562000													7	79					0	0	0.001984	0	0	
PCDH15	65217	broad.mit.edu	37	10	56423950	56423950	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr10:56423950A>C	uc001jju.1	-	2	468	c.73T>G	c.(73-75)TTG>GTG	p.L25V	PCDH15_uc010qhq.1_Missense_Mutation_p.L25V|PCDH15_uc010qhr.1_Missense_Mutation_p.L25V|PCDH15_uc010qhs.1_Missense_Mutation_p.L25V|PCDH15_uc010qht.1_Missense_Mutation_p.L25V|PCDH15_uc010qhu.1_Missense_Mutation_p.L25V|PCDH15_uc001jjv.1_Missense_Mutation_p.L25V|PCDH15_uc010qhv.1_Missense_Mutation_p.L25V|PCDH15_uc010qhw.1_Missense_Mutation_p.L25V|PCDH15_uc010qhx.1_Missense_Mutation_p.L25V|PCDH15_uc010qhy.1_Missense_Mutation_p.L25V|PCDH15_uc010qhz.1_Missense_Mutation_p.L25V|PCDH15_uc010qia.1_Missense_Mutation_p.L25V|PCDH15_uc010qib.1_Missense_Mutation_p.L25V|PCDH15_uc001jjw.2_Missense_Mutation_p.L25V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	25					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACTGGCCCAAGCAGATTTCA	0.388000										HNSCC(58;0.16)			4	35					0	0	0.009096	0	0	
TRIM22	10346	broad.mit.edu	37	11	5730455	5730455	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:5730455A>C	uc001mbr.2	+	8	1351	c.1074A>C	c.(1072-1074)GAA>GAC	p.E358D	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.E354D|TRIM22_uc010qzm.1_Missense_Mutation_p.E186D|TRIM22_uc009yeu.2_Missense_Mutation_p.E169D|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	358	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ATTACTGGGAAGTAGATGTGT	0.418000													20	139					0	0	0.014323	0	0	
NLRP14	338323	broad.mit.edu	37	11	7064388	7064388	+	Silent	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:7064388T>G	uc001mfb.1	+	4	1454	c.1131T>G	c.(1129-1131)ACT>ACG	p.T377T		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	377	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CCGCTTGTACTTGTCTGAAGC	0.463000													19	145					0	0	0.012319	0	0	
OR10A6	390093	broad.mit.edu	37	11	7950014	7950014	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:7950014A>C	uc010rbh.1	-	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACCACAGATAAGTTCAGGAGA	0.443000													20	166					0	0	0.002780	0	0	
AMPD3	272	broad.mit.edu	37	11	10500162	10500162	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:10500162C>T	uc001mio.1	+	3	646	c.311C>T	c.(310-312)CCG>CTG	p.P104L	AMPD3_uc010rbz.1_Intron|AMPD3_uc001min.1_Missense_Mutation_p.P113L|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.P104L|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.P111L|AMPD3_uc009yfy.2_Missense_Mutation_p.P104L	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	104					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GCAGCCAGTCCGGCCATGTCT	0.592000													8	84					0	0	0.007291	0	0	
COPB1	1315	broad.mit.edu	37	11	14497331	14497331	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:14497331C>T	uc001mli.2	-	13	1923	c.1616G>A	c.(1615-1617)AGA>AAA	p.R539K	COPB1_uc001mlg.2_Missense_Mutation_p.R539K|COPB1_uc001mlh.2_Missense_Mutation_p.R539K	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	539					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						CATAAATTACCTGTCTTCCTC	0.403000													4	123					0	0	0.000602	0	0	
QSER1	79832	broad.mit.edu	37	11	32954335	32954335	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:32954335T>G	uc001mty.2	+	4	1411	c.1144T>G	c.(1144-1146)TCT>GCT	p.S382A	QSER1_uc001mtz.1_Intron|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	382	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TTCTGGGTCATCTCAGACTGT	0.383000													25	123					0	0	0.007291	0	0	
OR4A15	81328	broad.mit.edu	37	11	55135904	55135904	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55135904T>G	uc010rif.1	+	1	545	c.545T>G	c.(544-546)CTT>CGT	p.L182R		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	182	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGAGGCTTTCTTCACTCATTG	0.423000													31	271					0	0	0.010818	0	0	
OR4C15	81309	broad.mit.edu	37	11	55322128	55322128	+	Silent	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55322128T>C	uc010rig.1	+	1	346	c.346T>C	c.(346-348)TTG>CTG	p.L116L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTACTTCTTCTTGGGCTTCCT	0.448000										HNSCC(20;0.049)			23	268					0	0	0.012319	0	0	
OR4C15	81309	broad.mit.edu	37	11	55322572	55322572	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55322572T>C	uc010rig.1	+	1	790	c.790T>C	c.(790-792)TTC>CTC	p.F264L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CATCATAAACTTCTCCTTGTT	0.478000										HNSCC(20;0.049)			13	115					0	0	0.013537	0	0	
OR5L2	26338	broad.mit.edu	37	11	55595575	55595575	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55595575A>T	uc001nhy.1	+	1	881	c.881A>T	c.(880-882)AAT>ATT	p.N294I		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				AGCCTGAGAAATAAGGATGTG	0.468000										HNSCC(27;0.073)			5	73					0	0	0.001984	0	0	
OR5W2	390148	broad.mit.edu	37	11	55681965	55681965	+	Silent	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55681965A>G	uc010rir.1	-	1	94	c.94T>C	c.(94-96)TTG>CTG	p.L32L		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAAACAGCCAAGAATACAGCA	0.353000													10	54					0	0	0.008291	0	0	
OR8H3	390152	broad.mit.edu	37	11	55890599	55890599	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:55890599T>C	uc001nii.1	+	1	751	c.751T>C	c.(751-753)TTC>CTC	p.F251L		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AGTCACCATCTTCTATGGAAC	0.388000													4	117					0	0	0.009096	0	0	
SLC29A2	3177	broad.mit.edu	37	11	66134027	66134027	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:66134027C>T	uc001oht.2	-	8	971	c.742G>A	c.(742-744)GGG>AGG	p.G248R	SLC29A2_uc001ohs.2_Missense_Mutation_p.G128R|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.G128R|SLC29A2_uc001ohu.2_Missense_Mutation_p.G248R|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	248					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						CTGGGAATCCCGTTCTCATCT	0.577000													4	59					0	0	0.009096	0	0	
PDE2A	5138	broad.mit.edu	37	11	72291953	72291953	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:72291953T>A	uc010rrc.1	-	24	2353	c.2110A>T	c.(2110-2112)AAC>TAC	p.N704Y	PDE2A_uc001oso.2_Missense_Mutation_p.N683Y|PDE2A_uc010rra.1_Missense_Mutation_p.N697Y|PDE2A_uc001osn.2_Missense_Mutation_p.N448Y|PDE2A_uc010rrb.1_Missense_Mutation_p.N695Y|PDE2A_uc010rrd.1_Missense_Mutation_p.N589Y	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	704	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AAAGAGTTGTTTGTGCCTCTG	0.532000													5	62					0	0	0.001168	0	0	
FAT3	120114	broad.mit.edu	37	11	92531044	92531044	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:92531044T>A	uc001pdj.3	+	9	4882	c.4865T>A	c.(4864-4866)ATC>AAC	p.I1622N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1622	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTCCTAGGCATCATCACCATT	0.443000										TCGA Ovarian(4;0.039)			13	93					0	0	0.004007	0	0	
TMEM133	83935	broad.mit.edu	37	11	100863358	100863358	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:100863358G>A	uc001pgf.2	+	1	548	c.319G>A	c.(319-321)GTT>ATT	p.V107I		NM_032021	NP_114410	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	107	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		CATTGTCACCGTTATCCCCCT	0.413000													59	136					0	0	0.014410	0	0	
DDI1	414301	broad.mit.edu	37	11	103908678	103908678	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:103908678A>C	uc001phr.2	+	1	1371	c.1128A>C	c.(1126-1128)CAA>CAC	p.Q376H	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	376					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TAAGTGGGCAAGATGAGTCTT	0.443000													8	57					0	0	0.004482	0	0	
FEZ1	9638	broad.mit.edu	37	11	125359440	125359440	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:125359440G>A	uc001qbx.2	-	2	386	c.234C>T	c.(232-234)AAC>AAT	p.N78N	FEZ1_uc010sbc.1_Silent_p.N78N|FEZ1_uc001qby.1_Silent_p.N78N	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	78					axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		CGGTCTTGGCGTTGTAGTTCC	0.458000													46	88					0	0	0.014410	0	0	
OPCML	4978	broad.mit.edu	37	11	132527068	132527068	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr11:132527068A>G	uc001qgs.2	-	2	364	c.314T>C	c.(313-315)GTG>GCG	p.V105A	OPCML_uc001qgu.2_Missense_Mutation_p.V98A|OPCML_uc010sck.1_Missense_Mutation_p.V105A|OPCML_uc001qgt.2_Missense_Mutation_p.V105A|OPCML_uc010scl.1_Missense_Mutation_p.V64A	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	105	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATACACATCCACATTTTGGAT	0.502000													13	90					0	0	0.002450	0	0	
ATF7IP	55729	broad.mit.edu	37	12	14577210	14577210	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:14577210C>T	uc001rbw.2	+	2	519	c.361C>T	c.(361-363)CCA>TCA	p.P121S	ATF7IP_uc010shs.1_Missense_Mutation_p.P121S|ATF7IP_uc001rbu.2_Missense_Mutation_p.P121S|ATF7IP_uc001rbv.1_Missense_Mutation_p.P121S|ATF7IP_uc001rbx.2_Missense_Mutation_p.P121S|ATF7IP_uc010sht.1_Missense_Mutation_p.P121S|ATF7IP_uc001rby.3_Missense_Mutation_p.P121S|ATF7IP_uc001rbz.1_Missense_Mutation_p.P121S|ATF7IP_uc001rca.2_Missense_Mutation_p.P121S|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	121					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AACTCCAGAACCAGTCTCTAA	0.463000													8	96					0	0	0.004482	0	0	
PLCZ1	89869	broad.mit.edu	37	12	18865822	18865822	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:18865822A>C	uc010sid.1	-	6	859	c.668T>G	c.(667-669)CTT>CGT	p.L223R	PLCZ1_uc001rdv.3_Missense_Mutation_p.L119R|PLCZ1_uc001rdw.3_Intron|PLCZ1_uc001rdu.1_5'UTR|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	223	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTTAAACAGAAGTTTGCTTGT	0.378000													5	37					0	0	0.000602	0	0	
GYS2	2998	broad.mit.edu	37	12	21733310	21733310	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:21733310C>T	uc001rfb.2	-	2	524	c.269G>A	c.(268-270)AGA>AAA	p.R90K		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	90					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GTCCACTGCTCTTCTGACAGC	0.408000													17	181					0	0	0.008871	0	0	
TM7SF3	51768	broad.mit.edu	37	12	27148201	27148201	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:27148201C>A	uc010sjl.1	-	5	897	c.659G>T	c.(658-660)AGT>ATT	p.S220I		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	220						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					CTGGGGCACACTGACCATCCT	0.498000													44	58					1.23713e-20	1.35363e-20	0.014410	1	0	
CPNE8	144402	broad.mit.edu	37	12	39087498	39087498	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:39087498T>G	uc001rls.1	-	15	1188	c.1104A>C	c.(1102-1104)AAA>AAC	p.K368N	CPNE8_uc001rlr.1_Missense_Mutation_p.K27N	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	368	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTGGAGGCAGTTTTGCACCAA	0.353000													5	139					0	0	0.001168	0	0	
SLC38A4	55089	broad.mit.edu	37	12	47173394	47173394	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:47173394C>T	uc001rpi.2	-	10	1116	c.717G>A	c.(715-717)GTG>GTA	p.V239V	SLC38A4_uc001rpj.2_Silent_p.V239V|SLC38A4_uc009zkl.2_Silent_p.V239V	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	239	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					CATCACTTACCACACTAACAA	0.378000													15	94					0	0	0.004007	0	0	
VDR	7421	broad.mit.edu	37	12	48272758	48272758	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:48272758A>T	uc001rqm.2	-	4	421	c.139T>A	c.(139-141)TTC>ATC	p.F47I	VDR_uc001rql.2_Missense_Mutation_p.F97I|VDR_uc001rqn.2_Missense_Mutation_p.F47I|VDR_uc010slq.1_5'UTR	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	47	Nuclear receptor.		F -> I (in VDDR2A).		decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CACCTGAAGAAGCCTTTGCAG	0.557000													4	65					0	0	0.000602	0	0	
AQP2	359	broad.mit.edu	37	12	50344953	50344953	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:50344953G>A	uc001rvn.2	+	1	430	c.340G>A	c.(340-342)GGG>AGG	p.G114R		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	114	Extracellular (Potential).				cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						AGACATCCGCGGGGACCTGGC	0.627000													5	10					0	0	0.001168	0	0	
KRT5	3852	broad.mit.edu	37	12	52910460	52910460	+	Missense_Mutation	SNP	A	G	G	rs60271599		TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:52910460A>G	uc001san.2	-	7	1563	c.1400T>C	c.(1399-1401)ATC>ACC	p.I467T	KRT5_uc009zmh.2_Missense_Mutation_p.I467T	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	467	Rod.|Coil 2.		I -> T (in DM-EBS).		epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GTAAGTGGCGATCTCCACGTC	0.587000													18	141					0	0	0.014323	0	0	
MYO1H	283446	broad.mit.edu	37	12	109826622	109826622	+	Silent	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:109826622C>A	uc010sxn.1	+	1	99	c.99C>A	c.(97-99)CGC>CGA	p.R33R		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						ACAACCTCCGCAAGCGTTTCA	0.527000													19	313					4.72057e-08	5.05184e-08	0.003954	1	0	
KNTC1	9735	broad.mit.edu	37	12	123019236	123019236	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:123019236C>T	uc001ucv.2	+	3	318	c.155C>T	c.(154-156)GCA>GTA	p.A52V	KNTC1_uc010taf.1_Missense_Mutation_p.A52V	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	52					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AAGATACAGGCATGCAGCTTA	0.338000													3	7					0	0	0.009096	0	0	
FZD10	11211	broad.mit.edu	37	12	130648113	130648113	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr12:130648113C>T	uc001uii.2	+	1	1082	c.626C>T	c.(625-627)CCG>CTG	p.P209L	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	209	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCGTGCGCGCCGCTCTGCACG	0.602000													3	25					0	0	0.009096	0	0	
USPL1	10208	broad.mit.edu	37	13	31232148	31232148	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:31232148T>C	uc001utc.2	+	9	2366	c.1934T>C	c.(1933-1935)ATT>ACT	p.I645T	USPL1_uc001utd.2_Missense_Mutation_p.I316T|USPL1_uc001ute.1_Missense_Mutation_p.I316T	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	645					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GAAAAGCTTATTCAAGACCAA	0.348000													22	126					0	0	0.012319	0	0	
NBEA	26960	broad.mit.edu	37	13	36006493	36006493	+	Silent	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:36006493T>G	uc001uvb.2	+	39	6473	c.6267T>G	c.(6265-6267)ACT>ACG	p.T2089T	NBEA_uc010abi.2_Silent_p.T745T	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2089						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TTGGCTCCACTCATGCTGAAG	0.433000													10	19					0	0	0.008291	0	0	
ENOX1	55068	broad.mit.edu	37	13	43896631	43896631	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:43896631G>A	uc001uza.3	-	11	1450	c.1150C>T	c.(1150-1152)CGG>TGG	p.R384W	ENOX1_uc001uzb.3_Missense_Mutation_p.R384W|ENOX1_uc001uzc.3_Missense_Mutation_p.R384W|ENOX1_uc001uyz.3_5'UTR|ENOX1_uc010tfm.1_Missense_Mutation_p.R197W	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	384					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TGAGCATTCCGGAGCTCCTGC	0.448000													17	135					0	0	0.012319	0	0	
C13orf31	144811	broad.mit.edu	37	13	44455529	44455529	+	Silent	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:44455529G>T	uc010acg.2	+	2	893	c.408G>T	c.(406-408)GTG>GTT	p.V136V	CCDC122_uc010acf.2_5'Flank|C13orf31_uc001uzf.3_Silent_p.V136V	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	136											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)		ATTTGCAAGTGACTTTTAGGG	0.328000													8	190					0.00448238	0.00465405	0.004482	1	0	
THSD1	55901	broad.mit.edu	37	13	52952648	52952648	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:52952648G>A	uc001vgo.2	-	5	2002	c.1457C>T	c.(1456-1458)ACG>ATG	p.T486M	THSD1_uc001vgp.2_Missense_Mutation_p.T433M|THSD1_uc010tgz.1_Missense_Mutation_p.T107M|THSD1_uc010aea.2_Translation_Start_Site	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	486	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		TGGACTCCCCGTGGGCCCGTC	0.652000													12	177					0	0	0.001855	0	0	
PCDH17	27253	broad.mit.edu	37	13	58299057	58299057	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:58299057A>C	uc001vhq.1	+	4	4001	c.3109A>C	c.(3109-3111)AGC>CGC	p.S1037R	PCDH17_uc010aec.1_Missense_Mutation_p.S1036R|PCDH17_uc001vhr.1_Missense_Mutation_p.S126R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1037	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTCAGCATCAAGCAGCCCAAC	0.532000													6	169					0	0	0.004482	0	0	
SCEL	8796	broad.mit.edu	37	13	78130848	78130848	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:78130848A>C	uc001vki.2	+	3	331	c.161A>C	c.(160-162)AAA>ACA	p.K54T	SCEL_uc001vkj.2_Missense_Mutation_p.K54T|SCEL_uc010thx.1_Missense_Mutation_p.K54T	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	54					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		GAAGAAGAAAAGTAAGCTGGT	0.453000													4	91					0	0	0.009096	0	0	
SLITRK1	114798	broad.mit.edu	37	13	84453960	84453960	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr13:84453960C>T	uc001vlk.2	-	1	2569	c.1683G>A	c.(1681-1683)CCG>CCA	p.P561P		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	561	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AGAAGTTCACCGGCGTCTCAC	0.522000													15	18					0	0	0.002450	0	0	
PRKD1	5587	broad.mit.edu	37	14	30068245	30068245	+	Silent	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:30068245A>G	uc001wqh.2	-	15	2335	c.2154T>C	c.(2152-2154)GAT>GAC	p.D718D		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	718	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GAGGAAAAGGATCAGCTGAGG	0.423000													23	144					0	0	0.007291	0	0	
PPP2R3C	55012	broad.mit.edu	37	14	35554856	35554856	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:35554856C>T	uc001wss.2	-	13	1656	c.1302G>A	c.(1300-1302)GAG>GAA	p.E434E	PPP2R3C_uc001wst.2_Silent_p.E318E|PPP2R3C_uc010tpr.1_Silent_p.E318E|PPP2R3C_uc001wsu.2_RNA	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	434						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		CCTCTCTGTTCTCGTAAGTCC	0.383000													10	77					0	0	0.008291	0	0	
LRFN5	145581	broad.mit.edu	37	14	42356892	42356892	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:42356892T>G	uc001wvm.2	+	3	2262	c.1064T>G	c.(1063-1065)TTT>TGT	p.F355C	LRFN5_uc010ana.2_Missense_Mutation_p.F355C	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	355	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ACAGGTGCTTTTACCTGCATT	0.388000										HNSCC(30;0.082)			8	156					0	0	0.003080	0	0	
C14orf106	55320	broad.mit.edu	37	14	45716199	45716199	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:45716199G>A	uc001wwf.2	-	2	750	c.291C>T	c.(289-291)CCC>CCT	p.P97P	C14orf106_uc010anh.2_RNA	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	97					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						CATCCTTGTTGGGCTTTATAG	0.313000													9	104					0	0	0.004482	0	0	
ABHD12B	145447	broad.mit.edu	37	14	51368592	51368592	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:51368592C>G	uc001wys.2	+	10	841	c.826C>G	c.(826-828)CTG>GTG	p.L276V	ABHD12B_uc001wyq.2_Missense_Mutation_p.L169V|ABHD12B_uc001wyr.2_Missense_Mutation_p.L199V|ABHD12B_uc010any.2_RNA	NM_181533	NP_853511	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B isoform b	276							hydrolase activity			breast(1)	1	all_epithelial(31;0.00481)|Breast(41;0.148)					TATGGATGCCCTGAGAAAAGA	0.308000													4	60					0	0	0.000602	0	0	
RHOJ	57381	broad.mit.edu	37	14	63735880	63735880	+	Silent	SNP	G	A	A	rs148425776		TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:63735880G>A	uc001xgb.1	+	2	674	c.231G>A	c.(229-231)GCG>GCA	p.A77A		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	77	GTP (By similarity).				actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		ATGACACCGCGGGACAGGTAC	0.398000													37	24					0	0	0.010771	0	0	
SIPA1L1	26037	broad.mit.edu	37	14	72138230	72138230	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:72138230T>C	uc001xms.2	+	8	2998	c.2650T>C	c.(2650-2652)TTC>CTC	p.F884L	SIPA1L1_uc001xmt.2_Missense_Mutation_p.F884L|SIPA1L1_uc001xmu.2_Missense_Mutation_p.F884L|SIPA1L1_uc001xmv.2_Missense_Mutation_p.F884L|SIPA1L1_uc010ttm.1_Missense_Mutation_p.F359L	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	884					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTCCAATGAGTTCATTGTGCT	0.488000													6	140					0	0	0.001984	0	0	
ACOT2	10965	broad.mit.edu	37	14	74036495	74036495	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr14:74036495A>G	uc001xon.3	+	1	724	c.551A>G	c.(550-552)CAG>CGG	p.Q184R	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Intron	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	184					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CTGCTGTGCCAGACGCGGCAC	0.736000													4	7					0	0	0.000602	0	0	
NF1P1	440225	broad.mit.edu	37	15	22145745	22145745	+	RNA	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:22145745A>C	uc010tzs.1	-	1		c.58T>G								Human NF1-related locus DNA in A9 mouse DNA background.												0						GCACTGAGTAAGTTTGACATT	0.473000													4	74					0	0	0.000602	0	0	
TJP1	7082	broad.mit.edu	37	15	30010566	30010567	+	Missense_Mutation	DNP	CT	GG	GG			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:30010566_30010567CT>GG	uc001zcr.2	-	21	4254_4255	c.3779_3780AG>CC	c.(3778-3780)AAG>ACC	p.K1260T	TJP1_uc010azl.2_Missense_Mutation_p.K1248T|TJP1_uc001zcq.2_Missense_Mutation_p.K1184T|TJP1_uc001zcs.2_Missense_Mutation_p.K1180T	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1260					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CAGACTGTGGCTTCATTGCTGG	0.441000													10	77					0	0	0.004672	0	0	
RYR3	6263	broad.mit.edu	37	15	34134178	34134178	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:34134178C>T	uc001zhi.2	+	91	13221	c.13151C>T	c.(13150-13152)CCG>CTG	p.P4384L	RYR3_uc010bar.2_Missense_Mutation_p.P4379L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4384					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTTGAGAAGCCGGAAGCTTTC	0.473000													4	1					0	0	0.000602	0	0	
GPR176	11245	broad.mit.edu	37	15	40094423	40094423	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:40094423T>C	uc001zkj.1	-	3	1324	c.458A>G	c.(457-459)AAA>AGA	p.K153R	GPR176_uc010uck.1_Missense_Mutation_p.K93R	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	153	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		ATCAGATATTTTCCTCTCCAG	0.448000											OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	36					0	0	0.014410	0	0	
SEMA6D	80031	broad.mit.edu	37	15	48052517	48052517	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:48052517G>A	uc010bek.2	+	3	486	c.126G>A	c.(124-126)CCG>CCA	p.P42P	SEMA6D_uc001zvw.2_Silent_p.P42P|SEMA6D_uc001zvx.1_Silent_p.P42P|SEMA6D_uc001zvy.2_Silent_p.P42P|SEMA6D_uc001zvz.2_Silent_p.P42P|SEMA6D_uc001zwa.2_Silent_p.P42P|SEMA6D_uc001zwb.2_Silent_p.P42P|SEMA6D_uc001zwc.2_Silent_p.P42P	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	42	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GGCAATATCCGGTTTTTAGAG	0.413000													21	19					0	0	0.012319	0	0	
USP8	9101	broad.mit.edu	37	15	50791187	50791187	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:50791187G>C	uc001zym.3	+	21	3759	c.3259G>C	c.(3259-3261)GAA>CAA	p.E1087Q	USP8_uc001zyl.3_Missense_Mutation_p.E1087Q|USP8_uc001zyn.3_Missense_Mutation_p.E1087Q|USP8_uc010ufh.1_Missense_Mutation_p.E981Q|USP8_uc001zyp.3_Missense_Mutation_p.E254Q	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	1087					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TGATGATCATGAAGTTTCTGA	0.423000													9	85					0	0	0.004482	0	0	
SGK269	79834	broad.mit.edu	37	15	77407493	77407493	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:77407493C>G	uc002bcm.2	-	6	4554	c.4246G>C	c.(4246-4248)GAT>CAT	p.D1416H		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1416	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCCATGTCATCCTCATCCTTT	0.488000													11	102					0	0	0.008291	0	0	
MEF2A	4205	broad.mit.edu	37	15	100211761	100211761	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:100211761C>T	uc010urw.1	+	4	654	c.295C>T	c.(295-297)CCA>TCA	p.P99S	MEF2A_uc010urv.1_Intron|MEF2A_uc010bos.2_Intron|MEF2A_uc002bvf.2_Missense_Mutation_p.P99S|MEF2A_uc002bve.2_Intron|MEF2A_uc002bvg.2_Intron|MEF2A_uc002bvi.2_Intron|MEF2A_uc010bot.2_Intron	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	99					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			GTGCGACAGCCCAGACCCTGA	0.333000													3	13					0	0	0.004672	0	0	
RHBDF1	64285	broad.mit.edu	37	16	108437	108437	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr16:108437C>T	uc002cfl.3	-	21	2618	c.2470G>A	c.(2470-2472)GTC>ATC	p.V824I		NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	824	Helical; (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				ACAGGATAGACGTAGAAGAGG	0.557000													111	172					0	0	0.014410	0	0	
BTBD12	84464	broad.mit.edu	37	16	3639115	3639115	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr16:3639115C>T	uc002cvp.2	-	12	5151	c.4524G>A	c.(4522-4524)TCG>TCA	p.S1508S		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1508	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CCCACAGAGCCGAATTCAGAA	0.632000								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				22	226					0	0	0.003954	0	0	
DNAH3	55567	broad.mit.edu	37	16	21008739	21008739	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr16:21008739G>A	uc010vbe.1	-	44	6467	c.6467C>T	c.(6466-6468)CCC>CTC	p.P2156L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2156	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GAGCTCGATGGGTGGCTGGGC	0.522000													10	104					0	0	0.013537	0	0	
SETD1A	9739	broad.mit.edu	37	16	30980994	30980994	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr16:30980994G>C	uc002ead.1	+	12	3686	c.3000G>C	c.(2998-3000)GAG>GAC	p.E1000D		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1000	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CAAAGAAGGAGACAGAGGTGT	0.507000													6	81					0	0	0.001168	0	0	
VKORC1	79001	broad.mit.edu	37	16	31104640	31104640	+	Silent	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr16:31104640T>A	uc002eas.2	-	2	502	c.276A>T	c.(274-276)CTA>CTT	p.L92L	PRSS53_uc002ear.2_5'UTR|VKORC1_uc002eat.2_Intron|VKORC1_uc002eau.2_Silent_p.L92L	NM_024006	NP_076869	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	92	Cytoplasmic (Potential).				peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity				0					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	CACCTAACAATAGCTGTAGTG	0.343000													33	51					0	0	0.005524	0	0	
TMEM102	284114	broad.mit.edu	37	17	7339728	7339728	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:7339728G>T	uc002ggx.1	+	3	703	c.430G>T	c.(430-432)GTC>TTC	p.V144F	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Missense_Mutation_p.V144F	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	144	Extracellular (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				TTACGCACAGGTCTGCCTCCC	0.592000													8	59					0.00621372	0.00642435	0.006214	1	0	
SHBG	6462	broad.mit.edu	37	17	7535245	7535245	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:7535245G>C	uc002gie.2	+	6	802	c.764G>C	c.(763-765)GGA>GCA	p.G255A	SHBG_uc010cmo.2_Missense_Mutation_p.G143A|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Missense_Mutation_p.G143A|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Missense_Mutation_p.G197A|SHBG_uc010cmu.2_Missense_Mutation_p.G197A|SHBG_uc010cmz.2_Intron|SHBG_uc010cmv.2_Missense_Mutation_p.G143A|SHBG_uc010cmw.2_Intron|SHBG_uc010cmx.2_Intron|SHBG_uc010cmy.2_Missense_Mutation_p.G197A|SHBG_uc002gid.3_Missense_Mutation_p.G197A|SHBG_uc010cnd.2_Intron|SHBG_uc010cna.2_Intron|SHBG_uc010vue.1_Missense_Mutation_p.G237A|SHBG_uc010vuf.1_Missense_Mutation_p.G255A|SHBG_uc010cnb.2_Intron|SHBG_uc010cnc.2_Missense_Mutation_p.G201A	NM_001040	NP_001031	P04278	SHBG_HUMAN	sex hormone-binding globulin isoform 1	255	Laminin G-like 2.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)			0		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	TTGGACCTGGGACTCAAGCAG	0.572000													161	131					0	0	0.014410	0	0	
TP53	7157	broad.mit.edu	37	17	7576897	7576897	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:7576897G>A	uc002gim.2	-	9	1143	c.949C>T	c.(949-951)CAG>TAG	p.Q317*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q317*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q185*|TP53_uc010cng.1_Nonsense_Mutation_p.Q185*|TP53_uc002gii.1_Nonsense_Mutation_p.Q185*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q317*|TP53_uc010cni.1_Nonsense_Mutation_p.Q317*|TP53_uc002gij.2_Nonsense_Mutation_p.Q317*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	317	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		Q -> H (in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation).|Q -> P (in a sporadic cancer; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q317*(19)|p.0?(7)|p.Q317K(3)|p.Q317R(2)|p.S315fs*22(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)|p.Q317P(1)|p.Q317fs*28(1)|p.Q317fs*45(1)|p.Q317fs*19(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTTTGGCTGGGGAGAGGAG	0.473000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			49	39					0	0	0.014410	0	0	
C17orf63	55731	broad.mit.edu	37	17	27085478	27085478	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:27085478C>A	uc002hct.1	-	3	1766	c.1499G>T	c.(1498-1500)GGG>GTG	p.G500V	C17orf63_uc010wax.1_Missense_Mutation_p.G500V|C17orf63_uc010way.1_Missense_Mutation_p.G500V|C17orf63_uc002hcw.2_Missense_Mutation_p.G372V	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	500										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			TGGACCGCCCCCGGTCCCTGC	0.637000													11	50					7.03913e-09	7.59976e-09	0.013537	1	0	
CCL8	6355	broad.mit.edu	37	17	32646540	32646540	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:32646540T>G	uc002hib.2	+	1	475	c.20T>G	c.(19-21)CTT>CGT	p.L7R		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	7					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				TCTGCAGCGCTTCTGTGCCTG	0.532000													13	61					0	0	0.003163	0	0	
CWC25	54883	broad.mit.edu	37	17	36963083	36963083	+	Silent	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:36963083T>A	uc002hqu.2	-	7	990	c.837A>T	c.(835-837)GCA>GCT	p.A279A	CWC25_uc010wdv.1_Silent_p.A216A|CWC25_uc010wdw.1_RNA|CWC25_uc010wdx.1_RNA	NM_017748	NP_060218	Q9NXE8	CWC25_HUMAN	coiled-coil domain containing 49	279											0						CCCGGGACCCTGCTTCCCTGG	0.567000													9	103					0	0	0.010729	0	0	
KIF2B	84643	broad.mit.edu	37	17	51901928	51901928	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:51901928T>A	uc002iua.2	+	1	1690	c.1534T>A	c.(1534-1536)TCC>ACC	p.S512T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	512					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGGCCAGAACTCCTCCACTTG	0.448000													5	70					0	0	0.000602	0	0	
TEX14	56155	broad.mit.edu	37	17	56699054	56699054	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:56699054G>A	uc010dcz.1	-	5	629	c.511C>T	c.(511-513)CGG>TGG	p.R171W	TEX14_uc002iwr.1_Missense_Mutation_p.R171W|TEX14_uc002iws.1_Missense_Mutation_p.R171W|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	171						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TAGACAAGCCGCTGCGGGGAG	0.587000													5	54					0	0	0.003080	0	0	
CACNG1	786	broad.mit.edu	37	17	65040761	65040761	+	Translation_Start_Site	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:65040761C>T	uc002jfu.2	+	1	56	c.-15C>T	c.(-17--13)CACGC>CATGC			NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1						muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	AGGGCACCCACGCCTCGGCGA	0.647000													4	42					0	0	0.000602	0	0	
DNAH17	8632	broad.mit.edu	37	17	76437168	76437168	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr17:76437168G>A	uc010dhp.1	-	17	2864	c.2642C>T	c.(2641-2643)CCG>CTG	p.P881L	DNAH17_uc002jvq.2_Missense_Mutation_p.P166L|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCAACCCCCGGGGAGAGGAT	0.473000													7	18					0	0	0.001984	0	0	
EPB41L3	23136	broad.mit.edu	37	18	5394733	5394733	+	Silent	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr18:5394733T>C	uc002kmt.1	-	22	3299	c.3213A>G	c.(3211-3213)AAA>AAG	p.K1071K	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Silent_p.K849K|EPB41L3_uc010dkq.1_Silent_p.K740K|EPB41L3_uc002kms.1_Silent_p.K306K|EPB41L3_uc010wze.1_Silent_p.K376K|EPB41L3_uc010wzf.1_Silent_p.K368K|EPB41L3_uc010wzg.1_Silent_p.K343K|EPB41L3_uc010dkr.2_Silent_p.K463K	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1071	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGACCACTACTTTGGTCACTG	0.507000													4	104					0	0	0.001168	0	0	
C18orf34	374864	broad.mit.edu	37	18	30672872	30672872	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr18:30672872T>A	uc002kxn.2	-	20	2383	c.2241A>T	c.(2239-2241)AAA>AAT	p.K747N	C18orf34_uc010xbq.1_Intron|C18orf34_uc010dme.1_Intron|C18orf34_uc010xbr.1_Missense_Mutation_p.K747N|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.K709N|C18orf34_uc002kxp.2_Missense_Mutation_p.K747N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	747										ovary(1)	1						CAGCTATTATTTTCTAGAAGG	0.234000													4	8					0	0	0.009096	0	0	
C18orf34	374864	broad.mit.edu	37	18	30846889	30846889	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr18:30846889G>T	uc002kxn.2	-	13	1542	c.1400C>A	c.(1399-1401)ACC>AAC	p.T467N	C18orf34_uc010dme.1_5'UTR|C18orf34_uc010xbr.1_Missense_Mutation_p.T467N|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.T467N|C18orf34_uc002kxp.2_Missense_Mutation_p.T467N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	467	Potential.									ovary(1)	1						CCTTTCATTGGTTTTTACTGT	0.294000													6	6					3.59834e-05	3.80084e-05	0.001168	1	0	
TCEB3C	162699	broad.mit.edu	37	18	44554652	44554652	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr18:44554652C>T	uc010xdb.1	-	1	1798	c.1562G>A	c.(1561-1563)CGA>CAA	p.R521Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						AGCCTGTTTTCGGGTTTTGTc	0.353000													17	307					0	0	0.004289	0	0	
PTPRS	5802	broad.mit.edu	37	19	5265160	5265160	+	Silent	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:5265160A>G	uc002mbv.2	-	5	661	c.427T>C	c.(427-429)TTG>CTG	p.L143L	PTPRS_uc002mbu.1_Silent_p.L143L|PTPRS_uc010xin.1_Silent_p.L143L|PTPRS_uc002mbw.2_Silent_p.L143L|PTPRS_uc002mbx.2_Silent_p.L143L|PTPRS_uc002mby.2_Silent_p.L143L	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	143	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		ACCACCTTCAACTGTGGGCCC	0.602000													13	34					0	0	0.001855	0	0	
ZNRF4	148066	broad.mit.edu	37	19	5456567	5456567	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:5456567G>A	uc002mca.3	+	1	1142	c.1065G>A	c.(1063-1065)GTG>GTA	p.V355V		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	355	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		AACAGTCGGTGGCCGCCACAG	0.637000													15	50					0	0	0.004990	0	0	
STXBP2	6813	broad.mit.edu	37	19	7707378	7707378	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:7707378C>A	uc002mha.3	+	10	903	c.858C>A	c.(856-858)GAC>GAA	p.D286E	STXBP2_uc002mhb.3_Missense_Mutation_p.D283E|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.D297E|STXBP2_uc010dvk.2_Missense_Mutation_p.D254E|STXBP2_uc002mhc.3_Missense_Mutation_p.D54E|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	286					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AGGACGATGACTTGTGGGTGG	0.667000													29	170					1.39806e-14	1.52288e-14	0.008361	1	0	
SLC1A6	6511	broad.mit.edu	37	19	15072963	15072963	+	Silent	SNP	G	A	A	rs115350519	byFrequency	TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:15072963G>A	uc002naa.1	-	5	794	c.786C>T	c.(784-786)TCC>TCT	p.S262S	SLC1A6_uc010dzu.1_Silent_p.S262S|SLC1A6_uc010xod.1_Silent_p.S198S|SLC1A6_uc002nab.2_Silent_p.S262S|SLC1A6_uc002nac.2_Silent_p.S262S	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	262	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TGCCATTGGCGGAGCCAGGCA	0.582000													9	65					0	0	0.010729	0	0	
OR10H2	26538	broad.mit.edu	37	19	15839756	15839756	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:15839756C>T	uc002nbm.2	+	1	923	c.903C>T	c.(901-903)GCC>GCT	p.A301A		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TGAAGGTTGCCATGAAGAGGA	0.517000													4	36					0	0	0.009096	0	0	
ZNF493	284443	broad.mit.edu	37	19	21607715	21607715	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:21607715C>T	uc002npx.2	+	2	2150	c.1870C>T	c.(1870-1872)CGG>TGG	p.R624W	ZNF493_uc002npw.2_Missense_Mutation_p.R752W|ZNF493_uc002npy.2_Missense_Mutation_p.R624W	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	624	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCTTTTAGGCGGTCTTCACA	0.373000													10	27					0	0	0.006214	0	0	
STRN4	29888	broad.mit.edu	37	19	47234126	47234126	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:47234126C>T	uc002pfl.2	-	6	775	c.742G>A	c.(742-744)GCG>ACG	p.A248T	STRN4_uc002pfm.2_Missense_Mutation_p.A248T|STRN4_uc010xyf.1_RNA|STRN4_uc010xyg.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	248						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		TTGCCTGCCGCGTTCCTGCCA	0.612000													8	124					0	0	0.003163	0	0	
SYT3	84258	broad.mit.edu	37	19	51132647	51132647	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:51132647G>A	uc002pst.2	-	4	1819	c.1185C>T	c.(1183-1185)CAC>CAT	p.H395H	SYT3_uc002psv.2_Silent_p.H395H|SYT3_uc010ycd.1_Silent_p.H395H	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	395	C2 1.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CGATGAGGTCGTGCCGCGAGA	0.637000													11	13					0	0	0.004007	0	0	
CLEC11A	6320	broad.mit.edu	37	19	51228685	51228685	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:51228685C>A	uc002psy.2	+	4	1111	c.933C>A	c.(931-933)TGC>TGA	p.C311*		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	311	C-type lectin.				positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		ACCACGACTGCCAGCGGCGTC	0.711000													4	13					0.00116845	0.00122361	0.001168	1	0	
ZIM2	23619	broad.mit.edu	37	19	57286430	57286430	+	Silent	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:57286430T>G	uc002qnr.2	-	11	1592	c.1210A>C	c.(1210-1212)AGA>CGA	p.R404R	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Silent_p.R200R|ZIM2_uc010ygr.1_Silent_p.R200R|ZIM2_uc002qnq.2_Silent_p.R404R|ZIM2_uc010etp.2_Silent_p.R404R|ZIM2_uc010ygs.1_Silent_p.R404R	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CTGTGAATTCTTACACGTTCA	0.468000													8	57					0	0	0.003080	0	0	
VN1R1	57191	broad.mit.edu	37	19	57967836	57967836	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:57967836T>G	uc002qos.1	-	1	19	c.19A>C	c.(19-21)AAA>CAA	p.K7Q	ZNF547_uc002qpm.3_Intron	NM_020633	NP_065684	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	7	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		GACAGAAGTTTTAATGTGTCT	0.373000													5	58					0	0	0.001984	0	0	
ZSCAN4	201516	broad.mit.edu	37	19	58190001	58190001	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:58190001G>A	uc002qpu.2	+	5	1727	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	344	C2H2-type 2.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTTTGTCCCGAGTGTCAAAA	0.423000													25	71					0	0	0.003330	0	0	
ZSCAN18	65982	broad.mit.edu	37	19	58601321	58601321	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr19:58601321A>C	uc002qri.2	-	2	623	c.314T>G	c.(313-315)GTC>GGC	p.V105G	ZSCAN18_uc002qrj.3_Missense_Mutation_p.V105G|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Missense_Mutation_p.V105G|ZSCAN18_uc010yht.1_Missense_Mutation_p.V161G|ZSCAN18_uc002qrk.1_Missense_Mutation_p.V105G|ZSCAN18_uc002qrl.2_Missense_Mutation_p.V105G	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	105	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCAGGGCCGGACCTTATCAGG	0.647000													7	103					0	0	0.004482	0	0	
WDR43	23160	broad.mit.edu	37	2	29137031	29137031	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:29137031T>C	uc002rmo.2	+	5	735	c.703T>C	c.(703-705)TAT>CAT	p.Y235H		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	235	WD 5.					nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TACAGGTCTTTATTTCTTATC	0.428000													6	47					0	0	0.001168	0	0	
TTC27	55622	broad.mit.edu	37	2	32958967	32958967	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:32958967G>T	uc002rom.2	+	11	1537	c.1306G>T	c.(1306-1308)GTA>TTA	p.V436L	TTC27_uc010ymx.1_Missense_Mutation_p.V386L|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	436							protein binding			central_nervous_system(1)	1						TTGCTGTCAAGTACCACCTCA	0.353000													16	124					2.94398e-08	3.16446e-08	0.007413	1	0	
LTBP1	4052	broad.mit.edu	37	2	33623444	33623444	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:33623444C>T	uc002ros.2	+	34	5001	c.5001C>T	c.(4999-5001)TGC>TGT	p.C1667C	LTBP1_uc002rot.2_Silent_p.C1341C|LTBP1_uc002rou.2_Silent_p.C1340C|LTBP1_uc002rov.2_Silent_p.C1287C|LTBP1_uc010ymz.1_Silent_p.C1298C|LTBP1_uc010yna.1_Silent_p.C1245C|LTBP1_uc010ynb.1_Silent_p.C564C	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1666	EGF-like 18; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAATGAATGCGATGAGTTGA	0.463000													28	55					0	0	0.009535	0	0	
ST6GAL2	84620	broad.mit.edu	37	2	107450508	107450508	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:107450508C>T	uc002tdq.2	-	3	1157	c.1038G>A	c.(1036-1038)TCG>TCA	p.S346S	ST6GAL2_uc002tdr.2_Silent_p.S346S|ST6GAL2_uc002tds.3_Silent_p.S346S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	346	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTCTTACCTGCGAATTAATGA	0.388000													8	114					0	0	0.003080	0	0	
CCDC138	165055	broad.mit.edu	37	2	109429148	109429148	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:109429148G>A	uc002ten.1	+	8	977	c.917G>A	c.(916-918)CGT>CAT	p.R306H	CCDC138_uc002teo.1_Missense_Mutation_p.R306H|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	306	Potential.										0						GTTCAAGCTCGTTTAGATAAT	0.318000													10	79					0	0	0.008291	0	0	
NCKAP5	344148	broad.mit.edu	37	2	133542769	133542769	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:133542769T>G	uc002ttp.2	-	14	1989	c.1615A>C	c.(1615-1617)AGT>CGT	p.S539R	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	539							protein binding				0						CTGGCGCAACTTGTCAGCTTT	0.552000													23	132					0	0	0.004656	0	0	
XIRP2	129446	broad.mit.edu	37	2	168103323	168103323	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:168103323C>G	uc002udx.2	+	8	5439	c.5421C>G	c.(5419-5421)GAC>GAG	p.D1807E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D1632E|XIRP2_uc010fpq.2_Missense_Mutation_p.D1585E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1632					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTGAAACTGACATCATCCCTG	0.388000													52	97					0	0	0.014410	0	0	
MYO3B	140469	broad.mit.edu	37	2	171323173	171323173	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:171323173G>A	uc002ufy.2	+	25	3109	c.2966G>A	c.(2965-2967)CGC>CAC	p.R989H	MYO3B_uc002ufv.2_Missense_Mutation_p.R976H|MYO3B_uc010fqb.1_Missense_Mutation_p.R976H|MYO3B_uc002ufz.2_Missense_Mutation_p.R989H|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	989	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GTCAGCATCCGCCGCCAGGGC	0.522000													26	74					0	0	0.003271	0	0	
TTN	7273	broad.mit.edu	37	2	179438783	179438783	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:179438783C>T	uc010zfg.1	-	275	64596	c.64372G>A	c.(64372-64374)GCA>ACA	p.A21458T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A15153T|TTN_uc010zfi.1_Missense_Mutation_p.A15086T|TTN_uc010zfj.1_Missense_Mutation_p.A14961T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22385							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTGGTGCCTCAACATCA	0.468000													23	48					0	0	0.012319	0	0	
TTN	7273	broad.mit.edu	37	2	179495978	179495978	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:179495978C>G	uc010zfg.1	-	186	36317	c.36093G>C	c.(36091-36093)GAG>GAC	p.E12031D	TTN_uc010zfh.1_Missense_Mutation_p.E5726D|TTN_uc010zfi.1_Missense_Mutation_p.E5659D|TTN_uc010zfj.1_Missense_Mutation_p.E5534D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12958							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCATCTTTCTCTACACCAG	0.353000													4	26					0	0	0.009096	0	0	
ERBB4	2066	broad.mit.edu	37	2	212426722	212426722	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:212426722A>G	uc002veg.1	-	20	2491	c.2393T>C	c.(2392-2394)CTT>CCT	p.L798P	ERBB4_uc002veh.1_Missense_Mutation_p.L798P|ERBB4_uc010zji.1_Missense_Mutation_p.L788P|ERBB4_uc010zjj.1_Missense_Mutation_p.L788P|ERBB4_uc010fut.1_Missense_Mutation_p.L798P	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	798	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATGGGGCATAAGTTGAGTAAC	0.493000										TSP Lung(8;0.080)			11	130					0	0	0.010729	0	0	
ABCA12	26154	broad.mit.edu	37	2	215818800	215818800	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:215818800C>T	uc002vew.2	-	44	6645	c.6425G>A	c.(6424-6426)CGC>CAC	p.R2142H	ABCA12_uc002vev.2_Missense_Mutation_p.R1824H|ABCA12_uc010zjn.1_Missense_Mutation_p.R1069H	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2142					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAGGAAAATGCGCTTGAGGGT	0.333000													12	118					0	0	0.001855	0	0	
CXCR2	3579	broad.mit.edu	37	2	219000083	219000083	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:219000083G>A	uc002vgz.1	+	4	784	c.559G>A	c.(559-561)GTC>ATC	p.V187I	CXCR2_uc002vha.1_Missense_Mutation_p.V187I|CXCR2_uc002vhb.1_Missense_Mutation_p.V187I	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	187	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CCGAAGGACCGTCTACTCATC	0.527000													13	105					0	0	0.001855	0	0	
ALPP	250	broad.mit.edu	37	2	233246019	233246019	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:233246019C>T	uc002vsq.2	+	10	1416	c.1251C>T	c.(1249-1251)AAC>AAT	p.N417N	ALPP_uc002vsr.2_RNA	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	417						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TATACGGAAACGGTCCAGGCT	0.657000													9	63					0	0	0.003163	0	0	
ANO7	50636	broad.mit.edu	37	2	242142897	242142897	+	Silent	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr2:242142897C>G	uc002wax.2	+	9	1138	c.1035C>G	c.(1033-1035)CTC>CTG	p.L345L		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	345	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						AGGTGGCCCTCTACTTCGCCT	0.647000													3	12					0	0	0.009096	0	0	
EIF6	3692	broad.mit.edu	37	20	33868600	33868600	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:33868600T>C	uc002xbv.1	-	3	442	c.226A>G	c.(226-228)ACC>GCC	p.T76A	EDEM2_uc010zuv.1_5'Flank|EIF6_uc002xbx.1_Missense_Mutation_p.T76A|EIF6_uc002xbz.1_Intron|EIF6_uc002xby.1_Intron	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	76					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGGTCGGTGGTATTGTTGGGT	0.567000													4	54					0	0	0.009096	0	0	
UQCC	55245	broad.mit.edu	37	20	33935043	33935043	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:33935043C>T	uc002xcd.2	-	7	564	c.497G>A	c.(496-498)CGG>CAG	p.R166Q	UQCC_uc010zuy.1_Missense_Mutation_p.R67Q|UQCC_uc010zuz.1_Missense_Mutation_p.R11Q|UQCC_uc010zva.1_Intron|UQCC_uc002xce.2_Missense_Mutation_p.R139Q|UQCC_uc002xcg.2_Missense_Mutation_p.R32Q|UQCC_uc010gfb.2_Missense_Mutation_p.R166Q|UQCC_uc010zvb.1_Missense_Mutation_p.R98Q|UQCC_uc002xcf.2_Missense_Mutation_p.R54Q|GDF5_uc010gfc.1_Intron|UQCC_uc002xci.1_Missense_Mutation_p.R120Q|UQCC_uc010gfd.1_Missense_Mutation_p.R152Q	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	166						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTTCCCACTCCGGCCTTCCTG	0.473000													14	252					0	0	0.004007	0	0	
PTPRT	11122	broad.mit.edu	37	20	40790013	40790013	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:40790013G>T	uc002xkg.2	-	17	2845	c.2661C>A	c.(2659-2661)TAC>TAA	p.Y887*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Y906*|PTPRT_uc010ggi.2_Nonsense_Mutation_p.Y90*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	887	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTTGAACCCGTAGCCCTGGC	0.512000													11	127					4.36969e-10	4.73869e-10	0.001855	1	0	
ZSWIM3	140831	broad.mit.edu	37	20	44486607	44486607	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:44486607G>A	uc002xqd.2	+	1	346	c.143G>A	c.(142-144)CGC>CAC	p.R48H	ACOT8_uc002xqa.1_5'Flank|ACOT8_uc010zxe.1_5'Flank|ACOT8_uc002xqc.1_5'Flank|ACOT8_uc010zxf.1_5'Flank|ZSWIM3_uc010zxg.1_5'UTR	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	48							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				ACCTCCATCCGCGAAGACATC	0.532000													9	83					0	0	0.007413	0	0	
SYCP2	10388	broad.mit.edu	37	20	58450395	58450395	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:58450395G>C	uc002yaz.2	-	33	3419	c.3280C>G	c.(3280-3282)CGA>GGA	p.R1094G		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1094					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			CAATTATCTCGTATAGCATCT	0.348000													6	60					0	0	0.001984	0	0	
OSBPL2	9885	broad.mit.edu	37	20	60847217	60847217	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr20:60847217G>A	uc002yck.1	+	5	497	c.295G>A	c.(295-297)GAG>AAG	p.E99K	OSBPL2_uc002ycl.1_Missense_Mutation_p.E87K|OSBPL2_uc011aah.1_Missense_Mutation_p.E7K	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	99					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			CGCCTTCAACGAGCCTCTGAG	0.602000													5	86					0	0	0.003080	0	0	
POTED	317754	broad.mit.edu	37	21	14982839	14982839	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr21:14982839A>C	uc002yjb.1	+	1	342	c.290A>C	c.(289-291)AAG>ACG	p.K97T		NM_174981	NP_778146	Q86YR6	POTED_HUMAN	pote protein	97						plasma membrane				ovary(3)|skin(3)	6						CTCAGGAGCAAGATGGGCAAG	0.607000													5	79					0	0	0.003080	0	0	
CCT8	10694	broad.mit.edu	37	21	30433674	30433674	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr21:30433674C>T	uc002ynb.2	-	13	1448	c.1349G>A	c.(1348-1350)CGC>CAC	p.R450H	CCT8_uc002ymz.2_Missense_Mutation_p.R66H|CCT8_uc011acp.1_Missense_Mutation_p.R431H|CCT8_uc002yna.2_Missense_Mutation_p.R399H|CCT8_uc002ync.2_Missense_Mutation_p.R449H|CCT8_uc010glm.2_Missense_Mutation_p.R391H|CCT8_uc011acq.1_Missense_Mutation_p.R377H	NM_006585	NP_006576	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	450					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding				0						TGCCAGTGCGCGGGGAATAGC	0.368000													10	111					0	0	0.013537	0	0	
GAL3ST1	9514	broad.mit.edu	37	22	30951855	30951855	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:30951855G>A	uc003aig.1	-	4	497	c.357C>T	c.(355-357)ACC>ACT	p.T119T	GAL3ST1_uc003aih.1_Silent_p.T119T|GAL3ST1_uc003aii.1_Silent_p.T119T|GAL3ST1_uc010gvz.1_Silent_p.T119T	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	119	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						GGGCGAAGAAGGTCGGGTAGT	0.632000													9	107					0	0	0.003163	0	0	
CYTH4	27128	broad.mit.edu	37	22	37688719	37688719	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:37688719G>A	uc003arf.2	+	2	193	c.77G>A	c.(76-78)CGA>CAA	p.R26Q	CYTH4_uc003ard.3_Missense_Mutation_p.R26Q|CYTH4_uc003are.2_Missense_Mutation_p.R26Q|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	26	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AAGTGGCACCGAAAGCAGCTC	0.612000													18	152					0	0	0.008871	0	0	
TRIOBP	11078	broad.mit.edu	37	22	38120337	38120337	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:38120337A>G	uc003atr.2	+	7	2045	c.1774A>G	c.(1774-1776)AGA>GGA	p.R592G	TRIOBP_uc003atu.2_Missense_Mutation_p.R420G|TRIOBP_uc003atq.1_Missense_Mutation_p.R592G|TRIOBP_uc003ats.1_Missense_Mutation_p.R420G	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	592					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTCTCCCAATAGAGCTACACG	0.582000													7	344					0	0	0.006214	0	0	
SLC16A8	23539	broad.mit.edu	37	22	38474460	38474460	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:38474460C>T	uc003auu.2	-	5	1580	c.1450G>A	c.(1450-1452)GCC>ACC	p.A484T		NM_013356	NP_037488	O95907	MOT3_HUMAN	solute carrier family 16, member 8	484	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|pyruvate metabolic process	integral to plasma membrane|membrane fraction	lactate transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity				0	Melanoma(58;0.045)				Pyruvic acid(DB00119)	TCGCCCCGGGCGCTGAGCACC	0.642000													61	70					0	0	0.014410	0	0	
SREBF2	6721	broad.mit.edu	37	22	42276858	42276858	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:42276858G>A	uc003bbi.2	+	10	2069	c.1900G>A	c.(1900-1902)GTG>ATG	p.V634M	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	634	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						GCTACGCCTGGTGCGCTGGCT	0.662000													7	47					0	0	0.003080	0	0	
KIAA1644	85352	broad.mit.edu	37	22	44681488	44681488	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:44681488C>T	uc003bet.2	-	4	552	c.419G>A	c.(418-420)CGA>CAA	p.R140Q		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	140	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TTTCATCCATCGTCCTTGGAT	0.637000													66	172					0	0	0.014410	0	0	
NUP50	10762	broad.mit.edu	37	22	45564068	45564068	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr22:45564068A>G	uc003bfr.2	+	2	472	c.10A>G	c.(10-12)AGA>GGA	p.R4G	NUP50_uc003bfs.2_5'UTR|NUP50_uc011aqn.1_5'UTR|NUP50_uc003bft.2_5'UTR	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	4					carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CATGGCCAAAAGAAATGCCGA	0.328000													6	79					0	0	0.004482	0	0	
MITF	4286	broad.mit.edu	37	3	70014029	70014029	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:70014029T>C	uc003dnz.2	+	10	1309	c.1193T>C	c.(1192-1194)CTT>CCT	p.L398P	MITF_uc011bgb.1_Missense_Mutation_p.L346P|MITF_uc003doa.2_Missense_Mutation_p.L397P|MITF_uc003dob.2_Missense_Mutation_p.L382P|MITF_uc003dod.2_Missense_Mutation_p.L373P|MITF_uc003doe.2_Missense_Mutation_p.L291P|MITF_uc003dof.2_Missense_Mutation_p.L297P	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	404	DNA binding regulation.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		GCTCATGGACTTTCCCTTATT	0.363000			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						22	129					0	0	0.003954	0	0	
ROBO1	6091	broad.mit.edu	37	3	78667086	78667086	+	Silent	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:78667086T>C	uc003dqe.2	-	27	4189	c.3981A>G	c.(3979-3981)CCA>CCG	p.P1327P	ROBO1_uc003dqb.2_Silent_p.P1288P|ROBO1_uc003dqc.2_Silent_p.P1227P|ROBO1_uc003dqd.2_Silent_p.P1282P|ROBO1_uc010hoh.2_Silent_p.P519P|ROBO1_uc011bgl.1_Silent_p.P899P	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1327	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTTCCTCTTCTGGCGCATCCG	0.557000													3	43					0	0	0.001168	0	0	
EPHA3	2042	broad.mit.edu	37	3	89259476	89259476	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:89259476A>C	uc003dqy.2	+	3	845	c.620A>C	c.(619-621)AAG>ACG	p.K207T	EPHA3_uc003dqx.1_Missense_Mutation_p.K207T|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	207	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TTTACAGTGAAGAATCTGGCT	0.453000										TSP Lung(6;0.00050)			14	124					0	0	0.004007	0	0	
EPHA3	2042	broad.mit.edu	37	3	89468391	89468391	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:89468391T>G	uc003dqy.2	+	11	2150	c.1925T>G	c.(1924-1926)CTT>CGT	p.L642R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	642	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCTTAAAACTTCCTTCAAAA	0.393000										TSP Lung(6;0.00050)			18	89					0	0	0.012319	0	0	
CCDC52	152185	broad.mit.edu	37	3	113187981	113187981	+	Missense_Mutation	SNP	G	A	A	rs148983792	byFrequency	TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:113187981G>A	uc003eag.3	-	8	1007	c.716C>T	c.(715-717)ACG>ATG	p.T239M	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.T135M	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	239					cell division|mitosis	centriole|spindle	protein binding				0						AGATGATGGCGTTCCTGGAGG	0.398000													32	134					0	0	0.003271	0	0	
GOLGB1	2804	broad.mit.edu	37	3	121448164	121448164	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:121448164G>C	uc003eei.3	-	4	399	c.273C>G	c.(271-273)AAC>AAG	p.N91K	GOLGB1_uc010hrc.2_Missense_Mutation_p.N91K|GOLGB1_uc003eej.3_Missense_Mutation_p.N52K|GOLGB1_uc011bjm.1_Missense_Mutation_p.N52K|GOLGB1_uc010hrd.1_Missense_Mutation_p.N91K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	91	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTTAATTTTGTTATCAGCAG	0.323000													13	157					0	0	0.002450	0	0	
MSL2	55167	broad.mit.edu	37	3	135870294	135870294	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:135870294G>A	uc003eqx.1	-	2	2162	c.1429C>T	c.(1429-1431)CGA>TGA	p.R477*	MSL2_uc011bmb.1_Nonsense_Mutation_p.R403*	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	477					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						CGTTGGCCTCGGCATGTAAGA	0.478000													17	53					0	0	0.004990	0	0	
SR140	23350	broad.mit.edu	37	3	142756989	142756989	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:142756989T>G	uc003evh.1	+	22	2360	c.2261T>G	c.(2260-2262)TTT>TGT	p.F754C	SR140_uc003evi.1_Missense_Mutation_p.F345C|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.F753C|SR140_uc003evl.1_Missense_Mutation_p.F321C	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	754					RNA processing	nucleus	nucleotide binding|RNA binding				0						GAGCCTATATTTAAAGTTGCC	0.348000													3	9					0	0	0.000602	0	0	
P2RY14	9934	broad.mit.edu	37	3	150931143	150931143	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:150931143T>C	uc003eyr.1	-	3	1440	c.962A>G	c.(961-963)GAC>GGC	p.D321G	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Missense_Mutation_p.D321G	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	321	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTGGAAATGTCTAGGTCATT	0.378000													30	213					0	0	0.008361	0	0	
IGSF10	285313	broad.mit.edu	37	3	151156235	151156235	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:151156235G>A	uc011bod.1	-	6	6114	c.6114C>T	c.(6112-6114)GCC>GCT	p.A2038A	IGSF10_uc011bob.1_Silent_p.A65A|IGSF10_uc011boc.1_Silent_p.A17A	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2038	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTCAATTTTGGCAGGTTTCA	0.433000													11	143					0	0	0.013537	0	0	
FNDC3B	64778	broad.mit.edu	37	3	172061989	172061989	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:172061989G>A	uc003fhy.2	+	19	2363	c.2191G>A	c.(2191-2193)GGC>AGC	p.G731S	FNDC3B_uc003fhz.3_Missense_Mutation_p.G731S	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	731	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GTGCACCGTCGGCAACCTGCT	0.562000													56	197					0	0	0.014410	0	0	
KCNMB3	27094	broad.mit.edu	37	3	178984528	178984528	+	Translation_Start_Site	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:178984528T>A	uc003fjp.1	-	1	311	c.-29A>T	c.(-31--27)AAAGG>AATGG		KCNMB3_uc011bqc.1_Translation_Start_Site	NM_171828	NP_741979	Q9NPA1	KCMB3_HUMAN	calcium-activated potassium channel beta 3						detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity				0	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			AATGGCTCCCTTTCACCTGAG	0.627000													6	42					0	0	0.001168	0	0	
ECE2	9718	broad.mit.edu	37	3	184008402	184008402	+	Silent	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:184008402C>T	uc003fni.3	+	15	2105	c.2067C>T	c.(2065-2067)ATC>ATT	p.I689I	ECE2_uc011brh.1_Silent_p.I542I|ECE2_uc003fnl.3_Silent_p.I617I|ECE2_uc003fnm.3_Silent_p.I571I|ECE2_uc003fnk.3_Silent_p.I542I|ECE2_uc011bri.1_Silent_p.I604I|ECE2_uc010hxv.2_Silent_p.I333I	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	689	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGAATGAGATCGTCTTCCCCG	0.507000													66	89					0	0	0.014410	0	0	
IGF2BP2	10644	broad.mit.edu	37	3	185369933	185369933	+	Silent	SNP	G	A	A	rs147590133	byFrequency	TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr3:185369933G>A	uc003fpo.2	-	13	1489	c.1410C>T	c.(1408-1410)GAC>GAT	p.D470D	IGF2BP2_uc010hyi.2_Silent_p.D413D|IGF2BP2_uc010hyj.2_Silent_p.D407D|IGF2BP2_uc010hyk.2_Silent_p.D334D|IGF2BP2_uc010hyl.2_Silent_p.D364D|IGF2BP2_uc003fpp.2_Silent_p.D427D|IGF2BP2_uc003fpq.2_Silent_p.D475D	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	470	KH 3.				anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTTCGCTGACGTCTGGGCCTT	0.597000													16	41					0	0	0.004007	0	0	
CPZ	8532	broad.mit.edu	37	4	8602891	8602891	+	Missense_Mutation	SNP	G	A	A	rs145429481		TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:8602891G>A	uc003glm.2	+	3	289	c.163G>A	c.(163-165)GCC>ACC	p.A55T	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Missense_Mutation_p.A44T|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	55	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAGTGATGCCGCCTACAACCA	0.642000													12	52					0	0	0.001855	0	0	
EPHA5	2044	broad.mit.edu	37	4	66197825	66197825	+	Silent	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:66197825T>C	uc003hcy.2	-	17	3067	c.2874A>G	c.(2872-2874)GAA>GAG	p.E958E	EPHA5_uc003hcx.2_Silent_p.E890E|EPHA5_uc003hcz.2_Silent_p.E936E|EPHA5_uc011cah.1_Silent_p.E959E|EPHA5_uc011cai.1_Silent_p.E937E|EPHA5_uc003hda.2_Silent_p.E959E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	958	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTGGGCTATGTTCTGCCAATA	0.328000										TSP Lung(17;0.13)			6	33					0	0	0.001984	0	0	
EPHA5	2044	broad.mit.edu	37	4	66231771	66231771	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:66231771T>G	uc003hcy.2	-	11	2122	c.1929A>C	c.(1927-1929)AAA>AAC	p.K643N	EPHA5_uc003hcx.2_Missense_Mutation_p.K575N|EPHA5_uc003hcz.2_Missense_Mutation_p.K621N|EPHA5_uc011cah.1_Missense_Mutation_p.K644N|EPHA5_uc011cai.1_Missense_Mutation_p.K622N|EPHA5_uc003hda.2_Missense_Mutation_p.K644N	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	643	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTCCTGGCAGTTTAACTGTAA	0.348000										TSP Lung(17;0.13)			4	39					0	0	0.009096	0	0	
GC	2638	broad.mit.edu	37	4	72620134	72620134	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:72620134T>G	uc003hge.2	-	10	1409	c.1256A>C	c.(1255-1257)AAG>ACG	p.K419T	GC_uc003hgd.2_Missense_Mutation_p.K297T|GC_uc010iie.2_Missense_Mutation_p.K419T|GC_uc010iif.2_Missense_Mutation_p.K438T	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	419	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTACTTTTTCTTGTACTCAGT	0.328000													3	6					0	0	0.004672	0	0	
PDHA2	5161	broad.mit.edu	37	4	96761480	96761480	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:96761480T>G	uc003htr.3	+	1	242	c.179T>G	c.(178-180)CTT>CGT	p.L60R		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	60					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GCGGAGGGGCTTAAATACTAC	0.458000													6	50					0	0	0.001984	0	0	
FAT4	79633	broad.mit.edu	37	4	126240751	126240751	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:126240751T>G	uc003ifj.3	+	1	3185	c.3185T>G	c.(3184-3186)CTT>CGT	p.L1062R		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1062	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GACCGTGAACTTCAAGACAGA	0.383000													25	155					0	0	0.008361	0	0	
FAT4	79633	broad.mit.edu	37	4	126371122	126371122	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:126371122T>G	uc003ifj.3	+	9	8951	c.8951T>G	c.(8950-8952)CTT>CGT	p.L2984R	FAT4_uc011cgp.1_Missense_Mutation_p.L1282R|FAT4_uc003ifi.1_Missense_Mutation_p.L462R	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2984	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCTCAATTTCTTAAAAGTAAA	0.338000													8	74					0	0	0.003080	0	0	
HSPA4L	22824	broad.mit.edu	37	4	128726846	128726846	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:128726846C>T	uc003ifm.2	+	10	1395	c.1142C>T	c.(1141-1143)GCG>GTG	p.A381V	HSPA4L_uc010iny.1_Missense_Mutation_p.A340V|HSPA4L_uc011cgr.1_Missense_Mutation_p.A348V	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	381					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TTTCAGTGTGCGATTCTCTCA	0.353000													7	43					0	0	0.001984	0	0	
PCDH18	54510	broad.mit.edu	37	4	138452730	138452730	+	Silent	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:138452730G>C	uc003ihe.3	-	1	900	c.513C>G	c.(511-513)CTC>CTG	p.L171L	PCDH18_uc003ihf.3_Silent_p.L164L|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	171	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AGTATGTGTGGAGGGAATTTT	0.463000													9	52					0	0	0.008291	0	0	
FGA	2243	broad.mit.edu	37	4	155508714	155508714	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:155508714G>T	uc003iod.1	-	4	518	c.460C>A	c.(460-462)CTT>ATT	p.L154I	FGA_uc003ioe.1_Missense_Mutation_p.L154I|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	154	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCTGCAGAAGCTGGATATGC	0.438000													8	96					0.000157383	0.000165524	0.003080	1	0	
FSTL5	56884	broad.mit.edu	37	4	162680664	162680664	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:162680664A>G	uc003iqh.2	-	6	1062	c.626T>C	c.(625-627)CTT>CCT	p.L209P	FSTL5_uc003iqi.2_Missense_Mutation_p.L208P|FSTL5_uc010iqv.2_Missense_Mutation_p.L208P	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	209	EF-hand 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATCCTTGCCAAGTTCTTCCTG	0.269000													6	68					0	0	0.004482	0	0	
ODZ3	55714	broad.mit.edu	37	4	183714348	183714348	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:183714348T>C	uc003ivd.1	+	25	6560	c.6523T>C	c.(6523-6525)TAT>CAT	p.Y2175H		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2175	Extracellular (Potential).|YD 20.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ACCCCTTCGCTATGACCTGCG	0.453000													20	57					0	0	0.008871	0	0	
TRIML1	339976	broad.mit.edu	37	4	189068074	189068074	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr4:189068074G>A	uc003izm.1	+	6	1070	c.955G>A	c.(955-957)GAC>AAC	p.D319N	TRIML1_uc003izn.1_Missense_Mutation_p.D43N	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	319	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GCAGCTACCCGACAACCCGGA	0.542000													15	113					0	0	0.004990	0	0	
AGXT2	64902	broad.mit.edu	37	5	35033594	35033594	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr5:35033594C>T	uc003jjf.2	-	6	725	c.646G>A	c.(646-648)GAA>AAA	p.E216K	AGXT2_uc011com.1_Missense_Mutation_p.E216K|AGXT2_uc011con.1_Missense_Mutation_p.E124K	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	216					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CCAGGGAGTTCCATCTTGTAG	0.473000													6	111					0	0	0.001984	0	0	
HCN1	348980	broad.mit.edu	37	5	45645499	45645499	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr5:45645499T>A	uc003jok.2	-	2	662	c.637A>T	c.(637-639)ATC>TTC	p.I213F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	213	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTCATCTTGATCACTTTGGGG	0.378000													6	113					0	0	0.001984	0	0	
PCDHB10	56126	broad.mit.edu	37	5	140572542	140572542	+	Silent	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr5:140572542C>G	uc003lix.2	+	1	591	c.417C>G	c.(415-417)GTC>GTG	p.V139V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	139	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGAAACAGTCTTAAAAATAT	0.408000													28	127					0	0	0.006320	0	0	
PCDHGA8	9708	broad.mit.edu	37	5	140773068	140773068	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr5:140773068G>A	uc003lkd.1	+	1	1586	c.688G>A	c.(688-690)GTG>ATG	p.V230M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V230M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCATCCACGTGACAGTGTT	0.607000													43	44					0	0	0.013114	0	0	
GABRA1	2554	broad.mit.edu	37	5	161322857	161322857	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr5:161322857A>G	uc010jiw.2	+	10	1510	c.1042A>G	c.(1042-1044)AGT>GGT	p.S348G	GABRA1_uc010jix.2_Missense_Mutation_p.S348G|GABRA1_uc010jiy.2_Missense_Mutation_p.S348G|GABRA1_uc003lyx.3_Missense_Mutation_p.S348G|GABRA1_uc010jiz.2_Missense_Mutation_p.S348G|GABRA1_uc010jja.2_Missense_Mutation_p.S348G|GABRA1_uc010jjb.2_Missense_Mutation_p.S348G	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	348	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GGATGGCAAAAGTGTGGTTCC	0.383000													10	110					0	0	0.010729	0	0	
MUC21	394263	broad.mit.edu	37	6	30955932	30955932	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:30955932G>A	uc003nsh.2	+	3	1913	c.1662G>A	c.(1660-1662)TCG>TCA	p.S554S	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	554	Cytoplasmic (Potential).|Cytoplasmic tail.					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CAGTATCCTCGATAGCCATGG	0.617000													9	26					0	0	0.010729	0	0	
TNXB	7148	broad.mit.edu	37	6	32015679	32015679	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:32015679C>T	uc003nzl.2	-	30	10352	c.10150G>A	c.(10150-10152)GTG>ATG	p.V3384M	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3431	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TACTGGACCACGAAGGAGTCG	0.632000													6	51					0	0	0.001168	0	0	
BRD2	6046	broad.mit.edu	37	6	32945673	32945673	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:32945673C>G	uc003ocn.3	+	9	3170	c.1469C>G	c.(1468-1470)TCC>TGC	p.S490C	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.S490C|BRD2_uc003ocp.3_Missense_Mutation_p.S370C|BRD2_uc010juh.2_Missense_Mutation_p.S490C	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	490	Glu/Ser-rich.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGTGAGAGCTCCTCTgaggaa	0.408000													46	64					0	0	0.011902	0	0	
SCUBE3	222663	broad.mit.edu	37	6	35199583	35199583	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:35199583G>A	uc003okf.1	+	4	422	c.416G>A	c.(415-417)CGG>CAG	p.R139Q	SCUBE3_uc003okg.1_Missense_Mutation_p.R139Q|SCUBE3_uc003okh.1_Missense_Mutation_p.R10Q	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	139	EGF-like 3; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						TGCCACTGCCGGGAAGGCTTC	0.607000													9	72					0	0	0.006214	0	0	
NCR2	9436	broad.mit.edu	37	6	41309551	41309551	+	Silent	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:41309551C>A	uc003oqh.2	+	3	501	c.414C>A	c.(412-414)ACC>ACA	p.T138T	NCR2_uc003oqi.2_Silent_p.T138T|NCR2_uc003oqj.2_Silent_p.T138T	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	138	Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCACACAGACCTCCTGGACTC	0.622000													9	119					1.08611e-07	1.15725e-07	0.010729	1	0	
RIMS1	22999	broad.mit.edu	37	6	72678732	72678732	+	Silent	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:72678732A>C	uc003pga.2	+	2	288	c.211A>C	c.(211-213)AGA>CGA	p.R71R		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	71	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAAACACCAAGAAATGCTGA	0.453000													14	89					0	0	0.004007	0	0	
KCNQ5	56479	broad.mit.edu	37	6	73751677	73751677	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:73751677G>A	uc003pgk.2	+	3	855	c.508G>A	c.(508-510)GTC>ATC	p.V170I	KCNQ5_uc003pgj.3_Missense_Mutation_p.V170I|KCNQ5_uc011dyh.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyi.1_Missense_Mutation_p.V170I|KCNQ5_uc010kat.2_Missense_Mutation_p.V170I|KCNQ5_uc011dyj.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	170	Helical; Name=Segment S2; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GATGATTGTCGTCTTTGGTTT	0.423000													117	266					0	0	0.014410	0	0	
EEF1A1	1915	broad.mit.edu	37	6	74229182	74229182	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:74229182C>G	uc003phi.2	-	2	239	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phf.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phg.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phh.2_Intron|EEF1A1_uc003phj.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phk.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phl.2_Missense_Mutation_p.E68Q|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	68						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ATACCACGTTCACGCTCAGCT	0.418000											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	47	148					0	0	0.014410	0	0	
TBX18	9096	broad.mit.edu	37	6	85470009	85470009	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:85470009G>C	uc003pkl.1	-	3	563	c.563C>G	c.(562-564)GCC>GGC	p.A188G	TBX18_uc010kbq.1_Missense_Mutation_p.A30G	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	188	T-box.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AATATCCATGGCAATGTAATA	0.398000													6	39					0	0	0.001168	0	0	
ASCC3	10973	broad.mit.edu	37	6	101246604	101246604	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr6:101246604G>C	uc003pqk.2	-	8	1709	c.1380C>G	c.(1378-1380)ATC>ATG	p.I460M	ASCC3_uc011eai.1_Missense_Mutation_p.I362M|ASCC3_uc003pql.2_Missense_Mutation_p.I460M	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTAAGTCTTGGATATAAACTG	0.368000													7	80					0	0	0.001984	0	0	
TXNDC3	51314	broad.mit.edu	37	7	37907401	37907401	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:37907401C>A	uc003tfn.2	+	11	1091	c.719C>A	c.(718-720)ACC>AAC	p.T240N		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	240	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTGAAGAAACCGAACCACAG	0.438000									Kartagener_syndrome				7	88					7.48243e-07	7.93788e-07	0.006214	1	0	
PCLO	27445	broad.mit.edu	37	7	82585562	82585562	+	Silent	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:82585562A>C	uc003uhx.2	-	5	4996	c.4707T>G	c.(4705-4707)GCT>GCG	p.A1569A	PCLO_uc003uhv.2_Silent_p.A1569A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1500					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGAACCTGAAGCATCTTCAT	0.418000													19	312					0	0	0.006122	0	0	
PCLO	27445	broad.mit.edu	37	7	82586037	82586037	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:82586037T>G	uc003uhx.2	-	5	4521	c.4232A>C	c.(4231-4233)AAG>ACG	p.K1411T	PCLO_uc003uhv.2_Missense_Mutation_p.K1411T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1342					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTTTCTAACTTAGCCAAATC	0.403000													8	126					0	0	0.004482	0	0	
ZNF804B	219578	broad.mit.edu	37	7	88965033	88965033	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:88965033T>G	uc011khi.1	+	4	3275	c.2737T>G	c.(2737-2739)TCA>GCA	p.S913A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	913						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AACCACAGAATCAAACACTGC	0.428000										HNSCC(36;0.09)			6	317					0	0	0.001168	0	0	
COL1A2	1278	broad.mit.edu	37	7	94038701	94038701	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:94038701T>A	uc003ung.1	+	17	1331	c.860T>A	c.(859-861)CTT>CAT	p.L287H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	287					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GAAGTGGGTCTTCCAGGCCTC	0.493000										HNSCC(75;0.22)			9	145					0	0	0.006122	0	0	
COPS6	10980	broad.mit.edu	37	7	99689073	99689073	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:99689073G>A	uc003usu.2	+	9	804	c.773G>A	c.(772-774)CGG>CAG	p.R258Q		NM_006833	NP_006824	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	258	Interaction with Vpr.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAGATCCTGCGGGAGGCCTAT	0.507000													18	283					0	0	0.012319	0	0	
NAPEPLD	222236	broad.mit.edu	37	7	102760348	102760348	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:102760348T>G	uc003vbc.2	-	3	945	c.617A>C	c.(616-618)GAG>GCG	p.E206A	NAPEPLD_uc003vbd.2_Missense_Mutation_p.E206A|NAPEPLD_uc011klj.1_Missense_Mutation_p.E279A|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	206					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						CCATCTCAACTCATTACCAAA	0.458000													21	335					0	0	0.014323	0	0	
GRM8	2918	broad.mit.edu	37	7	126882958	126882958	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:126882958G>A	uc003vlr.2	-	1	612	c.301C>T	c.(301-303)CGC>TGC	p.R101C	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.R101C|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	101	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCGAGGATGCGGACACCCAGA	0.483000										HNSCC(24;0.065)			6	126					0	0	0.001984	0	0	
MLL3	58508	broad.mit.edu	37	7	151860470	151860470	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:151860470G>A	uc003wla.2	-	43	10411	c.10192C>T	c.(10192-10194)CGG>TGG	p.R3398W	MLL3_uc003wkz.2_Missense_Mutation_p.R2459W|MLL3_uc003wky.2_Missense_Mutation_p.R907W	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3398	Potential.|Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTACGTTCCCGTTCTTGAAAA	0.468000			N		medulloblastoma								30	371					0	0	0.007291	0	0	
PTPRN2	5799	broad.mit.edu	37	7	157874063	157874063	+	Silent	SNP	G	A	A	rs145797552		TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr7:157874063G>A	uc003wno.2	-	11	1771	c.1650C>T	c.(1648-1650)CTC>CTT	p.L550L	PTPRN2_uc003wnp.2_Silent_p.L533L|PTPRN2_uc003wnq.2_Silent_p.L521L|PTPRN2_uc003wnr.2_Silent_p.L512L|PTPRN2_uc011kwa.1_Silent_p.L573L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	550	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTGCTGGTCCGAGAACCCTGG	0.433000													11	126					0	0	0.008291	0	0	
DKK4	27121	broad.mit.edu	37	8	42232307	42232307	+	Silent	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:42232307T>G	uc003xpb.2	-	3	498	c.387A>C	c.(385-387)CCA>CCC	p.P129P		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	129					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			TCTTAATACTTGGCTTCCTTT	0.448000													24	455					0	0	0.005443	0	0	
PXDNL	137902	broad.mit.edu	37	8	52322010	52322010	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:52322010G>A	uc003xqu.3	-	17	2275	c.2174C>T	c.(2173-2175)GCG>GTG	p.A725V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	725					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCGGTACTTCGCATGGAAACA	0.652000													14	46					0	0	0.001855	0	0	
FAM110B	90362	broad.mit.edu	37	8	59059176	59059176	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:59059176G>A	uc003xtj.1	+	5	1267	c.387G>A	c.(385-387)GAG>GAA	p.E129E		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	129						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				ATAGCTCCGAGGGCTCTAGCT	0.632000													7	43					0	0	0.001984	0	0	
RIMS2	9699	broad.mit.edu	37	8	104898169	104898169	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:104898169T>G	uc003yls.2	+	2	917	c.676T>G	c.(676-678)TTG>GTG	p.L226V	RIMS2_uc003ylp.2_Missense_Mutation_p.L448V|RIMS2_uc003ylw.2_Missense_Mutation_p.L256V|RIMS2_uc003ylq.2_Missense_Mutation_p.L256V|RIMS2_uc003ylr.2_Missense_Mutation_p.L256V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	479					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TAGACCAGACTTGAGGCGTAC	0.463000										HNSCC(12;0.0054)			13	93					0	0	0.002450	0	0	
KCNV1	27012	broad.mit.edu	37	8	110980483	110980483	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:110980483C>G	uc003ynr.3	-	3	1679	c.1337G>C	c.(1336-1338)AGA>ACA	p.R446T	KCNV1_uc010mcw.2_Missense_Mutation_p.R446T	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	446	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TTCACGCTGTCTAACAGCTGC	0.423000													21	75					0	0	0.010504	0	0	
COL22A1	169044	broad.mit.edu	37	8	139626133	139626133	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:139626133G>A	uc003yvd.2	-	56	4402	c.3955C>T	c.(3955-3957)CCC>TCC	p.P1319S	COL22A1_uc011ljo.1_Missense_Mutation_p.P599S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1319	Pro-rich.|Gly-rich.|Collagen-like 13.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGTCCTTGGGGACCCTGTGGC	0.453000										HNSCC(7;0.00092)			18	255					0	0	0.007413	0	0	
DENND3	22898	broad.mit.edu	37	8	142188188	142188188	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr8:142188188C>T	uc003yvy.2	+	16	2767	c.2489C>T	c.(2488-2490)GCG>GTG	p.A830V	DENND3_uc010mep.2_Missense_Mutation_p.A791V	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	830										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCAGCAGGCGCTGACCAAC	0.517000													36	93					0	0	0.010771	0	0	
SMU1	55234	broad.mit.edu	37	9	33068845	33068845	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:33068845G>A	uc003zsf.1	-	4	586	c.478C>T	c.(478-480)CGT>TGT	p.R160C	SMU1_uc010mjo.1_Missense_Mutation_p.R160C|SMU1_uc010mjp.1_Missense_Mutation_p.R160C|SMU1_uc011lnu.1_5'UTR	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	160						cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		GCCATGAGACGAGATGGAGGC	0.348000													31	47					0	0	0.012213	0	0	
FAM75A6	389730	broad.mit.edu	37	9	43624889	43624889	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:43624889T>G	uc011lrb.1	-	4	3827	c.3798A>C	c.(3796-3798)CAA>CAC	p.Q1266H		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1266						integral to membrane					0						TGAGAGTGGCTTGTTGACTGC	0.517000													13	178					0	0	0.004990	0	0	
FAM75A6	389730	broad.mit.edu	37	9	43627131	43627131	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:43627131A>T	uc011lrb.1	-	4	1585	c.1556T>A	c.(1555-1557)GTA>GAA	p.V519E		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	519						integral to membrane					0						AGGGCAAGCTACTCCAGTGTT	0.512000													53	302					0	0	0.014410	0	0	
PCSK5	5125	broad.mit.edu	37	9	78601082	78601082	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:78601082G>A	uc004ajz.2	+	3	870	c.332G>A	c.(331-333)CGG>CAG	p.R111Q	PCSK5_uc004ajy.2_Missense_Mutation_p.R111Q|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	111					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GTAAAAAAGCGGACAAAGAGG	0.443000													41	58					0	0	0.014410	0	0	
NTRK2	4915	broad.mit.edu	37	9	87570233	87570233	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:87570233G>A	uc004aoa.1	+	18	2863	c.1925G>A	c.(1924-1926)GGC>GAC	p.G642D	NTRK2_uc004any.1_Missense_Mutation_p.G642D|NTRK2_uc004anz.1_Missense_Mutation_p.G658D	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	642	Protein kinase.|Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						ATGGCTGAGGGCAACCCGCCC	0.642000										TSP Lung(25;0.17)			3	11					0	0	0.004672	0	0	
ACTL7B	10880	broad.mit.edu	37	9	111618016	111618016	+	Silent	SNP	G	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:111618016G>A	uc004bdi.2	-	1	260	c.195C>T	c.(193-195)TAC>TAT	p.Y65Y		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	65						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						GCTCTCCCGCGTAGCCGCACT	0.632000													101	136					0	0	0.014410	0	0	
SVEP1	79987	broad.mit.edu	37	9	113173353	113173353	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:113173353C>A	uc010mtz.2	-	37	6975	c.6638G>T	c.(6637-6639)GGC>GTC	p.G2213V	SVEP1_uc010mty.2_Missense_Mutation_p.G139V	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2213	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CTCCAGAAAGCCATTCTCAAC	0.458000													10	45					0.00136819	0.00142666	0.013537	1	0	
OR1L3	26735	broad.mit.edu	37	9	125437503	125437503	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:125437503T>G	uc011lzb.1	+	1	95	c.95T>G	c.(94-96)CTT>CGT	p.L32R		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCCCTCTTTCTTATCATATAC	0.443000													26	155					0	0	0.003954	0	0	
ABL1	25	broad.mit.edu	37	9	133759379	133759379	+	Missense_Mutation	SNP	G	A	A	rs141983052		TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr9:133759379G>A	uc004bzw.2	+	11	1705	c.1702G>A	c.(1702-1704)GTG>ATG	p.V568M	ABL1_uc004bzv.2_Missense_Mutation_p.V587M	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	568					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	TGAGCCTGCCGTGTCTCCATT	0.418000			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								16	154					0	0	0.008871	0	0	
KAL1	3730	broad.mit.edu	37	X	8555953	8555953	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:8555953T>G	uc004csf.2	-	5	758	c.608A>C	c.(607-609)AAG>ACG	p.K203T		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	203	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						CGAGGACCACTTAACCTCCAG	0.438000													7	32					0	0	0.004482	0	0	
DMD	1756	broad.mit.edu	37	X	32381009	32381009	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:32381009A>C	uc004dda.1	-	37	5465	c.5221T>G	c.(5221-5223)TTG>GTG	p.L1741V	DMD_uc004dcw.2_Missense_Mutation_p.L397V|DMD_uc004dcx.2_Missense_Mutation_p.L400V|DMD_uc004dcz.2_Missense_Mutation_p.L1618V|DMD_uc004dcy.1_Missense_Mutation_p.L1737V|DMD_uc004ddb.1_Missense_Mutation_p.L1733V|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1741	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTGCCATCAAGTTTGCTGCT	0.463000													11	77					0	0	0.008291	0	0	
DMD	1756	broad.mit.edu	37	X	32430012	32430012	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:32430012A>C	uc004dda.1	-	30	4334	c.4090T>G	c.(4090-4092)TTG>GTG	p.L1364V	DMD_uc004dcw.2_Missense_Mutation_p.L20V|DMD_uc004dcx.2_Missense_Mutation_p.L23V|DMD_uc004dcz.2_Missense_Mutation_p.L1241V|DMD_uc004dcy.1_Missense_Mutation_p.L1360V|DMD_uc004ddb.1_Missense_Mutation_p.L1356V|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1364	Spectrin 9.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGTTCAAGCAACTTTTGCCTC	0.393000													6	24					0	0	0.001984	0	0	
CXorf59	286464	broad.mit.edu	37	X	36122739	36122739	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:36122739A>T	uc004ddk.1	+	8	1162	c.976A>T	c.(976-978)ATT>TTT	p.I326F		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	326						integral to membrane				central_nervous_system(1)	1						TTCTGAAAGAATTTTGCTTAG	0.338000													13	62					0	0	0.013537	0	0	
USP11	8237	broad.mit.edu	37	X	47104245	47104245	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:47104245C>T	uc004dhp.2	+	15	2137	c.2137C>T	c.(2137-2139)CGC>TGC	p.R713C	USP11_uc004dhq.2_Missense_Mutation_p.R439C	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	713					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						AAGGCGACGACGCAAGCAGCT	0.597000													22	11					0	0	0.003954	0	0	
MAGEH1	28986	broad.mit.edu	37	X	55479467	55479467	+	Nonstop_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:55479467A>C	uc004dum.2	+	1	930	c.660A>C	c.(658-660)TAA>TAC	p.*220Y		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	220					apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCGCCCCTTAAGTAGATCTGA	0.502000													7	72					0	0	0.004482	0	0	
TSIX	9383	broad.mit.edu	37	X	73045157	73045157	+	RNA	SNP	G	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:73045157G>C	uc004ebn.2	+	1		c.33118G>C			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						AATTCCTTGTGTCTGCATAGT	0.308000													7	41					0	0	0.003080	0	0	
CYLC1	1538	broad.mit.edu	37	X	83128879	83128879	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:83128879A>C	uc004eei.1	+	4	1184	c.1163A>C	c.(1162-1164)AAG>ACG	p.K388T	CYLC1_uc004eeh.1_Missense_Mutation_p.K387T	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	388	4.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AGAAATTTGAAGAAAGCTTCA	0.303000													6	11					0	0	0.001984	0	0	
LOC442459	442459	broad.mit.edu	37	X	98974911	98974911	+	RNA	SNP	T	G	G			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chrX:98974911T>G	uc011mrd.1	-	8		c.1432A>C				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						GTCATCCAACTCCTCTTCCTG	0.468000													9	57					0	0	0.004482	0	0	
MEX3B	84206	broad.mit.edu	37	15	82336855	82336857	+	In_Frame_Del	DEL	TCC	-	-			TCGA-CG-4436-01A-01D-1158-08	TCGA-CG-4436-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	bdc1981a-f12f-47b8-a23a-439aaac8c9ce	27c8e775-c1fc-4bfa-b1e4-f0b353eff25b	g.chr15:82336855_82336857delTCC	uc002bgq.1	-	2	669_671	c.354_356delGGA	c.(352-357)GAGGAT>GAT	p.E118del		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	118	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						CATGGCCACATCCTCCTTCCTGC	0.576													11	25	---	---	---	---						.
