Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	68					0	0	0.004482	0	0	
ARID1A	8289	broad.mit.edu	37	1	27099124	27099124	+	Splice_Site	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:27099124G>A	uc001bmv.1	+	13	3912	c.3539_splice	c.e13+1	p.S1180_splice	ARID1A_uc001bmt.1_Splice_Site_p.R1180_splice|ARID1A_uc001bmu.1_Splice_Site_p.S1180_splice|ARID1A_uc001bmw.1_Splice_Site_p.S797_splice|ARID1A_uc001bmx.1_Splice_Site_p.R27_splice|ARID1A_uc009vsm.1_5'Flank|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGCATGAGGTAAGGCCAAG	0.572000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								42	25					0	0	0.010771	0	0	
C1orf87	127795	broad.mit.edu	37	1	60499178	60499178	+	Silent	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:60499178G>T	uc001czs.1	-	7	1091	c.999C>A	c.(997-999)CGC>CGA	p.R333R		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	333							calcium ion binding			ovary(1)|breast(1)	2						CAGAGAACGAGCGATCTTCTT	0.428000													46	69					2.43468e-25	2.72281e-25	0.014410	1	0	
LRRC39	127495	broad.mit.edu	37	1	100614640	100614640	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:100614640G>A	uc001dsw.1	-	10	1165	c.966C>T	c.(964-966)AAC>AAT	p.N322N	CCDC76_uc001dsv.2_3'UTR|CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_3'UTR|LRRC39_uc001dsx.1_Silent_p.N322N|LRRC39_uc001dsy.1_3'UTR|LRRC39_uc001dsz.1_Silent_p.N322N	NM_144620	NP_653221	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	322										ovary(2)|skin(1)	3		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		TAGTTGAACCGTTGACTTGGT	0.303000													3	26					0	0	0.004672	0	0	
NTNG1	22854	broad.mit.edu	37	1	107867370	107867370	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:107867370G>A	uc001dvh.3	+	3	1431	c.713G>A	c.(712-714)CGC>CAC	p.R238H	NTNG1_uc001dvf.3_Missense_Mutation_p.R238H|NTNG1_uc010out.1_Missense_Mutation_p.R238H|NTNG1_uc001dvc.3_Missense_Mutation_p.R238H|NTNG1_uc001dvd.1_Missense_Mutation_p.R238H	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	238	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CCTCGCCTACGCAATATGGCT	0.433000													10	48					0	0	0.016723	0	0	
SPAG17	200162	broad.mit.edu	37	1	118624180	118624180	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:118624180C>T	uc001ehk.2	-	14	1916	c.1848G>A	c.(1846-1848)GGG>GGA	p.G616G		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	616						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GTTTCAGTTTCCCTTTTTCAT	0.438000													21	85					0	0	0.008871	0	0	
BCL9	607	broad.mit.edu	37	1	147095750	147095750	+	Missense_Mutation	SNP	C	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:147095750C>G	uc001epq.2	+	10	4011	c.3271C>G	c.(3271-3273)CAG>GAG	p.Q1091E	BCL9_uc010ozr.1_Missense_Mutation_p.Q1005E	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1091	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TCACTCCAATCAGATGCCCTC	0.537000			T	IGH@|IGL@	B-ALL								14	298					0	0	0.020292	0	0	
OR6Y1	391112	broad.mit.edu	37	1	158517100	158517100	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:158517100G>A	uc010pil.1	-	1	796	c.796C>T	c.(796-798)CGT>TGT	p.R266C		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGTTTGGGACGGGCATAGGTG	0.483000													21	103					0	0	0.010504	0	0	
CACNA1E	777	broad.mit.edu	37	1	181706750	181706750	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:181706750C>T	uc001gow.2	+	23	3677	c.3512C>T	c.(3511-3513)GCG>GTG	p.A1171V	CACNA1E_uc009wxs.2_Missense_Mutation_p.A1059V|CACNA1E_uc001gox.1_Missense_Mutation_p.A397V|CACNA1E_uc009wxt.2_Missense_Mutation_p.A397V	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1171	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ATCGCCCTGGCGGCAGAGGAC	0.622000													86	73					0	0	0.014410	0	0	
IVNS1ABP	10625	broad.mit.edu	37	1	185270181	185270181	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:185270181T>C	uc001grl.2	-	10	1666	c.1043A>G	c.(1042-1044)GAA>GGA	p.E348G	IVNS1ABP_uc001gri.2_Missense_Mutation_p.E8G|IVNS1ABP_uc001grj.2_Missense_Mutation_p.E8G|IVNS1ABP_uc009wyj.2_Missense_Mutation_p.E130G|IVNS1ABP_uc009wyk.2_RNA|IVNS1ABP_uc001grm.2_Missense_Mutation_p.E8G	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	348	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						CATGGGCTTTTCGATTAGCTC	0.438000													51	36					0	0	0.014410	0	0	
SIPA1L2	57568	broad.mit.edu	37	1	232615460	232615460	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:232615460C>T	uc001hvg.2	-	5	2156	c.1998G>A	c.(1996-1998)ACG>ACA	p.T666T		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	666	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AGAGAGAGTGCGTGCCCGTGG	0.433000													7	61					0	0	0.003080	0	0	
OR2G6	391211	broad.mit.edu	37	1	248685576	248685576	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr1:248685576C>T	uc001ien.1	+	1	629	c.629C>T	c.(628-630)CCG>CTG	p.P210L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTAATTGTCCCGGTGTTACTC	0.478000													14	83					0	0	0.020292	0	0	
ITGA8	8516	broad.mit.edu	37	10	15628600	15628600	+	Silent	SNP	C	T	T	rs145199076	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:15628600C>T	uc001ioc.1	-	23	2355	c.2355G>A	c.(2353-2355)GCG>GCA	p.A785A	ITGA8_uc010qcb.1_Silent_p.A770A	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	785	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TTTCCACCTGCGCTACAGCAG	0.363000													19	37					0	0	0.012319	0	0	
PTCHD3	374308	broad.mit.edu	37	10	27702628	27702628	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:27702628G>A	uc001itu.2	-	1	670	c.552C>T	c.(550-552)TTC>TTT	p.F184F		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	184					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GGCCCTGCACGAAGCGCCGCT	0.627000													162	207					0	0	0.014410	0	0	
ZNF438	220929	broad.mit.edu	37	10	31139181	31139181	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:31139181C>T	uc010qdz.1	-	7	588	c.153G>A	c.(151-153)CTG>CTA	p.L51L	ZNF438_uc001ivn.2_Silent_p.L2L|ZNF438_uc010qdy.1_Silent_p.L41L|ZNF438_uc001ivo.3_5'UTR|ZNF438_uc009xlg.2_Silent_p.L51L|ZNF438_uc001ivp.3_Silent_p.L41L|ZNF438_uc010qea.1_Silent_p.L51L|ZNF438_uc010qeb.1_Silent_p.L51L|ZNF438_uc010qec.1_5'UTR	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				AATGACATGGCAGCATTCTGG	0.488000													73	173					0	0	0.014410	0	0	
ARHGAP12	94134	broad.mit.edu	37	10	32150542	32150542	+	Silent	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:32150542A>G	uc001ivz.1	-	4	999	c.729T>C	c.(727-729)TAT>TAC	p.Y243Y	ARHGAP12_uc001ivy.1_Silent_p.Y241Y|ARHGAP12_uc009xls.2_Silent_p.Y241Y|ARHGAP12_uc001iwb.1_Silent_p.Y241Y|ARHGAP12_uc001iwc.1_Silent_p.Y241Y|ARHGAP12_uc009xlq.1_Silent_p.Y241Y|ARHGAP12_uc001iwd.1_Silent_p.Y241Y|ARHGAP12_uc009xlr.1_Silent_p.Y241Y	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	243					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GAAGGTTAGCATAGACAGGAG	0.398000													14	67					0	0	0.004007	0	0	
BMS1	9790	broad.mit.edu	37	10	43287160	43287160	+	Missense_Mutation	SNP	T	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:43287160T>G	uc001jaj.2	+	6	1080	c.722T>G	c.(721-723)GTT>GGT	p.V241G		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	241					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTTATTACAGTTATGAAGTTT	0.398000													14	58					0	0	0.004990	0	0	
RET	5979	broad.mit.edu	37	10	43596039	43596039	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:43596039G>A	uc001jal.2	+	2	396	c.206G>A	c.(205-207)GGC>GAC	p.G69D	RET_uc001jak.1_Missense_Mutation_p.G69D	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	69	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TTCCGCCTGGGCCAGCATCTC	0.637000		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				10	63					0	0	0.008291	0	0	
Unknown	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:48968566A>G	uc001jgc.1	+	3		c.1234A>G								full-length cDNA clone CS0DI009YC01 of Placenta Cot 25-normalized of Homo sapiens (human).																		ACAGGATAACAAACTGGAAAA	0.284000													4	20					0	0	0.009096	0	0	
SIRT1	23411	broad.mit.edu	37	10	69672419	69672419	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:69672419C>T	uc001jnd.2	+	8	1599	c.1546C>T	c.(1546-1548)CGA>TGA	p.R516*	SIRT1_uc010qis.1_Nonsense_Mutation_p.R221*|SIRT1_uc009xpp.2_Nonsense_Mutation_p.R324*|SIRT1_uc001jne.2_Nonsense_Mutation_p.R213*	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	516					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						AAAACCTCCACGAACACAAAA	0.388000													6	40					0	0	0.001168	0	0	
IFIT1B	439996	broad.mit.edu	37	10	91143907	91143907	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:91143907G>A	uc001kgh.2	+	2	917	c.837G>A	c.(835-837)GAG>GAA	p.E279E	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	279	TPR 5.						binding				0						TGGCCTTGGAGACAACACCCA	0.458000													9	147					0	0	0.008291	0	0	
MGEA5	10724	broad.mit.edu	37	10	103550838	103550838	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:103550838C>T	uc001ktv.2	-	14	2712	c.2269G>A	c.(2269-2271)GGA>AGA	p.G757R	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.G704R|MGEA5_uc009xws.2_Missense_Mutation_p.G690R	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	757	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		AGCAGCCCTCCTACTAACCTG	0.448000													4	56					0	0	0.001168	0	0	
SORCS1	114815	broad.mit.edu	37	10	108923946	108923946	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:108923946C>T	uc001kym.2	-	1	347	c.339G>A	c.(337-339)GCG>GCA	p.A113A	SORCS1_uc001kyl.2_Silent_p.A113A|SORCS1_uc009xxs.2_Silent_p.A113A|SORCS1_uc001kyn.1_Silent_p.A113A|SORCS1_uc001kyo.2_Silent_p.A113A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	113	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCTCCTGATCCGCTCCGCTCC	0.721000													11	60					0	0	0.010729	0	0	
DCLRE1A	9937	broad.mit.edu	37	10	115609996	115609996	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:115609996C>T	uc001law.2	-	2	1786	c.868G>A	c.(868-870)GAA>AAA	p.E290K		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	290					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		AAGTCATTTTCTGGCAATGGC	0.378000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					5	79					0	0	0.014758	0	0	
PNLIP	5406	broad.mit.edu	37	10	118320019	118320019	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:118320019G>A	uc001lcm.2	+	11	1195	c.1152G>A	c.(1150-1152)AAG>AAA	p.K384K		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	384	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	GAAACTCTAAGCAGTATGAAA	0.264000													16	16					0	0	0.003163	0	0	
MGMT	4255	broad.mit.edu	37	10	131334524	131334524	+	Missense_Mutation	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr10:131334524A>G	uc001lkh.2	+	2	127	c.101A>G	c.(100-102)AAG>AGG	p.K34R		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	3										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		AAAATGGACAAGGATTGTGAA	0.433000								Direct_reversal_of_damage					7	84					0	0	0.004482	0	0	
MICAL2	9645	broad.mit.edu	37	11	12229626	12229626	+	Missense_Mutation	SNP	A	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:12229626A>T	uc001mjz.2	+	5	817	c.529A>T	c.(529-531)ATC>TTC	p.I177F	MICAL2_uc010rch.1_Missense_Mutation_p.I177F|MICAL2_uc001mjy.2_Missense_Mutation_p.I177F|MICAL2_uc001mka.2_Missense_Mutation_p.I177F|MICAL2_uc010rci.1_Missense_Mutation_p.I177F|MICAL2_uc001mkb.2_Missense_Mutation_p.I177F|MICAL2_uc001mkc.2_Missense_Mutation_p.I177F|MICAL2_uc001mkd.2_Missense_Mutation_p.I6F	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	177						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GGGAGTTGAAATCCATGTGAA	0.443000													79	112					0	0	0.014410	0	0	
KCNA4	3739	broad.mit.edu	37	11	30032457	30032457	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:30032457G>A	uc001msk.2	-	2	2921	c.1769C>T	c.(1768-1770)CCC>CTC	p.P590L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	590						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAAATTAGAGGGGAGGTATGG	0.433000													18	68					0	0	0.004990	0	0	
OR4C3	256144	broad.mit.edu	37	11	48346854	48346854	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:48346854G>A	uc010rhv.1	+	1	362	c.362G>A	c.(361-363)TGC>TAC	p.C121Y		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTTATGAGTGCTGCATGGCT	0.458000													44	398					0	0	0.014410	0	0	
OR4C46	119749	broad.mit.edu	37	11	51515370	51515370	+	Missense_Mutation	SNP	T	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:51515370T>G	uc010ric.1	+	1	89	c.89T>G	c.(88-90)TTT>TGT	p.F30C		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTTGTGTTTTTTGTCATCTAT	0.433000													88	127					0	0	0.014410	0	0	
OR4C11	219429	broad.mit.edu	37	11	55371644	55371644	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:55371644G>A	uc010rii.1	-	1	206	c.206C>T	c.(205-207)TCT>TTT	p.S69F		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAAAAGCAAGAATCTGCAAA	0.408000													28	66					0	0	0.006320	0	0	
EML3	256364	broad.mit.edu	37	11	62376557	62376557	+	Missense_Mutation	SNP	C	T	T	rs35971607	byFrequency	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:62376557C>T	uc001ntu.1	-	7	1114	c.806G>A	c.(805-807)CGC>CAC	p.R269H	EML3_uc001ntr.1_Missense_Mutation_p.R241H|EML3_uc001nts.1_Missense_Mutation_p.R241H|EML3_uc001ntt.1_Missense_Mutation_p.R153H|EML3_uc010rly.1_Missense_Mutation_p.R269H|EML3_uc009yny.1_Missense_Mutation_p.R52H	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	269						cytoplasm|microtubule	protein binding			ovary(1)	1						CTCCCCAGAGCGCAACACAAA	0.597000													65	515					0	0	0.014410	0	0	
DSCAML1	57453	broad.mit.edu	37	11	117299086	117299086	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:117299086C>T	uc001prh.1	-	33	6302	c.6300G>A	c.(6298-6300)AAG>AAA	p.K2100K		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2040	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGGCCCCCTGCTTCTGAGACC	0.692000													40	47					0	0	0.013114	0	0	
CHEK1	1111	broad.mit.edu	37	11	125514068	125514068	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr11:125514068G>A	uc009zbo.2	+	10	1898	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	CHEK1_uc010sbh.1_Missense_Mutation_p.D352N|CHEK1_uc010sbi.1_Missense_Mutation_p.D336N|CHEK1_uc001qcf.3_Missense_Mutation_p.D336N|CHEK1_uc009zbp.2_Missense_Mutation_p.D336N|CHEK1_uc001qcg.3_Missense_Mutation_p.D336N|CHEK1_uc009zbq.2_Missense_Mutation_p.D336N|CHEK1_uc001qci.1_RNA|CHEK1_uc001qcj.2_5'UTR	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	336					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		CTCATACATTGATAAATTGGT	0.468000								Other_conserved_DNA_damage_response_genes					7	91					0	0	0.001984	0	0	
LOC653113	653113	broad.mit.edu	37	12	8386955	8386955	+	RNA	SNP	T	C	C	rs75997195		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:8386955T>C	uc010sgk.1	-	4		c.501A>G				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						CTTGTGCTCCTGGCAGGCAGC	0.612000													10	118					0	0	0.016723	0	0	
A2M	2	broad.mit.edu	37	12	9254201	9254201	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:9254201G>T	uc001qvk.1	-	12	1449	c.1336C>A	c.(1336-1338)CAC>AAC	p.H446N	A2M_uc009zgk.1_Missense_Mutation_p.H296N	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	446					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TAAGCAGTGTGATGTGCCTCT	0.443000													6	24					8.12818e-05	8.34906e-05	0.001984	1	0	
KLRC1	3821	broad.mit.edu	37	12	10603730	10603730	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:10603730G>A	uc001qyl.2	-	2	190	c.26C>T	c.(25-27)TCA>TTA	p.S9L	KLRC1_uc009zhm.1_Missense_Mutation_p.S9L|KLRC1_uc001qym.2_Missense_Mutation_p.S9L|KLRC1_uc001qyn.2_Missense_Mutation_p.S9L|KLRC1_uc001qyo.2_Missense_Mutation_p.S9L	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	9	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						ATTCAGGTCTGAGTAGATTAC	0.388000													6	42					0	0	0.001168	0	0	
SLC4A8	9498	broad.mit.edu	37	12	51882580	51882580	+	Missense_Mutation	SNP	T	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:51882580T>G	uc001rys.1	+	18	2562	c.2384T>G	c.(2383-2385)ATC>AGC	p.I795S	SLC4A8_uc001rym.2_Missense_Mutation_p.I742S|SLC4A8_uc001ryn.2_Missense_Mutation_p.I742S|SLC4A8_uc001ryo.2_Missense_Mutation_p.I742S|SLC4A8_uc010snj.1_Missense_Mutation_p.I822S|SLC4A8_uc001ryr.2_Missense_Mutation_p.I795S	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	795	Helical; (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		CTCTGTACTATCTTGATATTC	0.458000													9	61					0	0	0.004482	0	0	
SP1	6667	broad.mit.edu	37	12	53776035	53776035	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:53776035C>T	uc001scw.2	+	3	401	c.304C>T	c.(304-306)CAG>TAG	p.Q102*	SP1_uc010sog.1_Nonsense_Mutation_p.Q95*	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	102	Ser/Thr-rich.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		ACAACTTTCACAGGGTGCCAA	0.552000													24	32					0	0	0.016522	0	0	
CALCOCO1	57658	broad.mit.edu	37	12	54109688	54109688	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:54109688G>A	uc001sef.2	-	9	1293	c.1149C>T	c.(1147-1149)AGC>AGT	p.S383S	CALCOCO1_uc001see.2_5'Flank|CALCOCO1_uc010som.1_Silent_p.S298S|CALCOCO1_uc010son.1_Silent_p.S260S|CALCOCO1_uc001seh.2_Silent_p.S383S|CALCOCO1_uc009znd.2_Silent_p.S383S|CALCOCO1_uc001seg.2_Silent_p.S208S|CALCOCO1_uc010soo.1_Silent_p.S376S	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	383					steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CTTCCAGGCGGCTGCGGTGTA	0.602000													12	48					0	0	0.016723	0	0	
NEUROD4	58158	broad.mit.edu	37	12	55420273	55420273	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:55420273C>T	uc001sgp.3	+	2	428	c.50C>T	c.(49-51)ACA>ATA	p.T17I		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	17					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CTAGTCAACACACCATCCTGG	0.443000													15	19					0	0	0.004990	0	0	
MMP19	4327	broad.mit.edu	37	12	56234970	56234970	+	Missense_Mutation	SNP	G	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:56234970G>C	uc001sib.2	-	3	345	c.224C>G	c.(223-225)GCC>GGC	p.A75G	MMP19_uc001sia.2_5'Flank|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_Missense_Mutation_p.A75G	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	75					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						GGCCCTTGTGGCATCATCCAG	0.522000													13	92					0	0	0.016723	0	0	
USP44	84101	broad.mit.edu	37	12	95926835	95926835	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:95926835C>A	uc001teg.2	-	2	1342	c.1198G>T	c.(1198-1200)GTC>TTC	p.V400F	USP44_uc001teh.2_Missense_Mutation_p.V400F|USP44_uc009zte.2_Missense_Mutation_p.V397F	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	400					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						AATGGTGAGACCAACGCCCAC	0.443000													51	45					7.90463e-13	8.537e-13	0.014410	1	0	
MMP17	4326	broad.mit.edu	37	12	132329865	132329865	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr12:132329865C>T	uc001ujc.1	+	8	1174	c.1075C>T	c.(1075-1077)CGG>TGG	p.R359W	MMP17_uc001ujd.1_Missense_Mutation_p.R275W	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	359	Hemopexin-like 1.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GCGGCTGACGCGGGACCGGCA	0.711000													18	31					0	0	0.004990	0	0	
MIPEP	4285	broad.mit.edu	37	13	24380153	24380153	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr13:24380153G>A	uc001uox.3	-	16	1884	c.1784C>T	c.(1783-1785)TCA>TTA	p.S595L		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	595					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		GTCTGTGGTTGAATTCCTCAG	0.403000													40	96					0	0	0.007835	0	0	
LECT1	11061	broad.mit.edu	37	13	53298181	53298181	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr13:53298181C>T	uc001vhf.2	-	4	530	c.419G>A	c.(418-420)CGT>CAT	p.R140H	LECT1_uc001vhg.2_Missense_Mutation_p.R140H|LECT1_uc001vhh.2_Intron	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	140	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CTCAGGAATACGAGCCTTCAC	0.473000													14	59					0	0	0.020292	0	0	
MYCBP2	23077	broad.mit.edu	37	13	77754282	77754282	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr13:77754282C>T	uc001vkf.2	-	35	5090	c.4999G>A	c.(4999-5001)GCG>ACG	p.A1667T	MYCBP2_uc010aev.2_Missense_Mutation_p.A1071T	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1667					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGGGCTGACGCTGTCAGTTCA	0.428000													34	44					0	0	0.015359	0	0	
Unknown	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:19857036A>G	uc001vvq.1	-	5		c.494T>C								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		CTGGATAATAAAGTTCATCTC	0.373000													7	40					0	0	0.001984	0	0	
NKX2-1	7080	broad.mit.edu	37	14	36987207	36987207	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:36987207G>A	uc001wtt.2	-	2	733	c.392C>T	c.(391-393)CCG>CTG	p.P131L	SFTA3_uc001wts.2_Intron|NKX2-1_uc001wtu.2_Missense_Mutation_p.P161L|NKX2-1_uc001wtv.2_Missense_Mutation_p.P131L|uc001wtw.1_5'Flank	NM_003317	NP_003308	P43699	NKX21_HUMAN	thyroid transcription factor 1 isoform 2	131					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			skin(1)	1	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		GCCGCTCGCCGGGCCCATGAA	0.716000			A		NSCLC								5	30					0	0	0.001168	0	0	
KCNH5	27133	broad.mit.edu	37	14	63417125	63417125	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:63417125G>A	uc001xfx.2	-	7	1146	c.1095C>T	c.(1093-1095)TGC>TGT	p.C365C	KCNH5_uc001xfy.2_Silent_p.C365C|KCNH5_uc001xfz.1_Silent_p.C307C|KCNH5_uc001xga.2_Silent_p.C307C	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	365	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TATACCATATGCAGGCCAGCC	0.522000													11	101					0	0	0.013537	0	0	
C14orf156	81892	broad.mit.edu	37	14	78174460	78174460	+	Silent	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:78174460G>T	uc001xue.3	+	1	36	c.6G>T	c.(4-6)GCG>GCT	p.A2A	ALKBH1_uc001xuc.1_5'Flank|ALKBH1_uc001xud.1_5'Flank	NM_031210	NP_112487	Q9GZT3	SLIRP_HUMAN	SRA stem-loop-interacting RNA-binding protein	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	nucleotide binding|RNA binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0276)		TGAAGATGGCGGCCTCAGCAG	0.562000													8	41					1.01871e-10	1.09396e-10	0.008871	1	0	
INF2	64423	broad.mit.edu	37	14	105174317	105174317	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:105174317G>A	uc001ypb.2	+	8	1856	c.1713G>A	c.(1711-1713)AAG>AAA	p.K571K	INF2_uc010tyi.1_Silent_p.K571K|INF2_uc001ypc.2_Silent_p.K571K|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	571	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		ACTGGCAGAAGCTGCCATCCA	0.657000													25	54					0	0	0.018920	0	0	
PACS2	23241	broad.mit.edu	37	14	105836184	105836184	+	Missense_Mutation	SNP	A	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr14:105836184A>T	uc001yqt.2	+	8	923	c.748A>T	c.(748-750)AAC>TAC	p.N250Y	PACS2_uc001yqs.2_Missense_Mutation_p.N175Y|PACS2_uc001yqv.2_Missense_Mutation_p.N250Y|PACS2_uc001yqu.2_Missense_Mutation_p.N250Y	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	250					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCAGCAACAGAACTTCAAGCA	0.677000													9	7					0	0	0.006214	0	0	
Unknown	0	broad.mit.edu	37	15	20588661	20588661	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:20588661C>A	uc001ytg.2	-	27	4109	c.3400G>T	c.(3400-3402)GAG>TAG	p.E1134*	uc010tyx.1_RNA					RecName: Full=Putative HERC2-like protein 3;																		AGTATTTGCTCTAACTTTGTA	0.358000													7	55					0.00198382	0.00199437	0.001984	1	0	
DISP2	85455	broad.mit.edu	37	15	40656717	40656717	+	Missense_Mutation	SNP	G	T	T	rs146996300		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:40656717G>T	uc001zlk.1	+	4	664	c.575G>T	c.(574-576)CGG>CTG	p.R192L		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	192					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TTGGGGGCCCGGCTGCCCGAC	0.637000													12	142					7.93312e-07	8.23824e-07	0.020292	1	0	
DISP2	85455	broad.mit.edu	37	15	40661395	40661395	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:40661395C>A	uc001zlk.1	+	8	3171	c.3082C>A	c.(3082-3084)CTC>ATC	p.L1028I		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	1028	Helical; (Potential).				smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CTCAGTGGGCCTCTCAGTAGA	0.602000													33	203					4.31634e-10	4.55747e-10	0.012213	1	0	
PLA2G4F	255189	broad.mit.edu	37	15	42438358	42438358	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:42438358C>T	uc001zoz.2	-	14	1564	c.1501G>A	c.(1501-1503)GTC>ATC	p.V501I	PLA2G4F_uc010bcq.2_5'Flank|PLA2G4F_uc001zoy.2_Missense_Mutation_p.V133I|PLA2G4F_uc010bcr.2_Missense_Mutation_p.V252I|PLA2G4F_uc001zpa.2_Missense_Mutation_p.V252I|PLA2G4F_uc010bcs.2_Missense_Mutation_p.V288I	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	501	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		TTGGTGCGGACGTTGACACTG	0.592000													31	90					0	0	0.013726	0	0	
CAPN3	825	broad.mit.edu	37	15	42652295	42652295	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:42652295G>A	uc001zpn.1	+	1	598	c.292G>A	c.(292-294)GTC>ATC	p.V98I	CAPN3_uc001zpk.1_Intron|CAPN3_uc001zpl.1_Intron|CAPN3_uc010udf.1_Intron|CAPN3_uc010udg.1_Intron|CAPN3_uc001zpo.1_Missense_Mutation_p.V98I|CAPN3_uc001zpp.1_Missense_Mutation_p.V98I	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	98	Calpain catalytic.		Missing (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CATCCAGTTCGTCTGGAAGAG	0.532000													137	271					0	0	0.014410	0	0	
UNC13C	440279	broad.mit.edu	37	15	54306827	54306827	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:54306827G>T	uc002ack.2	+	1	1727	c.1727G>T	c.(1726-1728)AGC>ATC	p.S576I		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	576					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACTAATGGAAGCTCTCTCCTG	0.433000													29	36					5.61819e-17	6.17347e-17	0.005443	1	0	
BNC1	646	broad.mit.edu	37	15	83932806	83932806	+	Silent	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:83932806T>C	uc002bjt.1	-	4	1285	c.1197A>G	c.(1195-1197)CTA>CTG	p.L399L	BNC1_uc010uos.1_Silent_p.L387L	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	399	C2H2-type 2.				epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCCGGCTCCTTAGGGAGCTGA	0.517000													106	116					0	0	0.014410	0	0	
NTRK3	4916	broad.mit.edu	37	15	88420326	88420326	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr15:88420326C>T	uc002bme.1	-	19	2522	c.2360G>A	c.(2359-2361)CGT>CAT	p.R787H	NTRK3_uc002bmh.2_Missense_Mutation_p.R765H|NTRK3_uc002bmf.1_Missense_Mutation_p.R773H	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	787	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTCCAAAACACGACCTTGGGT	0.537000			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			20	61					0	0	0.012319	0	0	
DCI	1632	broad.mit.edu	37	16	2290000	2290000	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:2290000G>A	uc002cpr.2	-	7	925	c.889C>T	c.(889-891)CTC>TTC	p.L297F	DCI_uc002cps.2_Missense_Mutation_p.L280F	NM_001919	NP_001910	P42126	ECI1_HUMAN	dodecenoyl-Coenzyme A delta isomerase precursor	297					fatty acid beta-oxidation	mitochondrial matrix	dodecenoyl-CoA delta-isomerase activity				0						TCTTCTTTGAGCCTCTCTAAG	0.537000													60	57					0	0	0.014410	0	0	
OR1F1	4992	broad.mit.edu	37	16	3254578	3254578	+	Missense_Mutation	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:3254578A>G	uc010uwu.1	+	1	332	c.332A>G	c.(331-333)GAC>GGC	p.D111G		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGGACATGGACAATTTCCTC	0.507000													33	254					0	0	0.012213	0	0	
ZFHX3	463	broad.mit.edu	37	16	72821612	72821612	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:72821612G>A	uc002fck.2	-	10	11236	c.10563C>T	c.(10561-10563)GGC>GGT	p.G3521G	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.G2607G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3521	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				cgccgccgccgccgccaccgc	0.408000													19	35					0	0	0.008871	0	0	
ZFHX3	463	broad.mit.edu	37	16	72821614	72821614	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:72821614C>T	uc002fck.2	-	10	11234	c.10561G>A	c.(10561-10563)GGC>AGC	p.G3521S	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Missense_Mutation_p.G2607S	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3521	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ccgccgccgccgccaccgccg	0.408000													17	35					0	0	0.006122	0	0	
PLCG2	5336	broad.mit.edu	37	16	81925130	81925130	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:81925130C>T	uc002fgt.2	+	11	1073	c.921C>T	c.(919-921)GAC>GAT	p.D307D	PLCG2_uc010chg.1_Silent_p.D307D	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	307					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						AGAAGTATGACGCGGTGGACA	0.498000													20	38					0	0	0.010504	0	0	
LRRC50	123872	broad.mit.edu	37	16	84203642	84203642	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr16:84203642C>A	uc002fhl.3	+	8	1389	c.1208C>A	c.(1207-1209)GCT>GAT	p.A403D	LRRC50_uc010vnw.1_Missense_Mutation_p.A167D	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	403	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CCTGTGGAGGCTAAAAGAGAG	0.557000									Kartagener_syndrome				17	102					2.23348e-06	2.30671e-06	0.004007	1	0	
SGSM2	9905	broad.mit.edu	37	17	2279113	2279113	+	Missense_Mutation	SNP	G	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:2279113G>C	uc002fun.3	+	17	2468	c.2293G>C	c.(2293-2295)GCC>CCC	p.A765P	SGSM2_uc002fum.3_Missense_Mutation_p.A810P|SGSM2_uc010vqw.1_Missense_Mutation_p.A765P|SGSM2_uc002fup.1_5'UTR|SGSM2_uc002fuq.2_5'Flank	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	765	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GAAGCCTCAGGCCGGAGAACT	0.682000													41	48					0	0	0.010771	0	0	
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	rs28934578		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652000	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	27					0	0	0.013726	0	0	
CCDC144NL	339184	broad.mit.edu	37	17	20799061	20799061	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:20799061G>A	uc002gyf.2	-	1	393	c.273C>T	c.(271-273)GGC>GGT	p.G91G	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	91											0						CAGGGACGTCGCCCGACCGGG	0.642000													72	37					0	0	0.014410	0	0	
SPAG5	10615	broad.mit.edu	37	17	26919760	26919760	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:26919760C>T	uc002hbq.2	-	3	594	c.502G>A	c.(502-504)GAT>AAT	p.D168N	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	168					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					CTCACCAGATCGTCTGTTCTC	0.473000													35	75					0	0	0.013726	0	0	
SCN4A	6329	broad.mit.edu	37	17	62019209	62019209	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:62019209G>A	uc002jds.1	-	24	4510	c.4433C>T	c.(4432-4434)TCG>TTG	p.S1478L		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1478	IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GGCAGGCAGCGACATCATGAG	0.607000													21	59					0	0	0.014323	0	0	
TTYH2	94015	broad.mit.edu	37	17	72233438	72233438	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr17:72233438C>T	uc002jkc.2	+	4	451	c.420C>T	c.(418-420)TCC>TCT	p.S140S	TTYH2_uc010wqw.1_Silent_p.S119S	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	140	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CCTAGGTTTCCGGAACTACCC	0.557000													31	114					0	0	0.009535	0	0	
MYOM1	8736	broad.mit.edu	37	18	3188832	3188832	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr18:3188832C>T	uc002klp.2	-	4	1019	c.685G>A	c.(685-687)GCT>ACT	p.A229T	MYOM1_uc002klq.2_Missense_Mutation_p.A229T	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	229						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TGTTGAAGAGCGGATGTGGCC	0.512000													15	41					0	0	0.020292	0	0	
SETBP1	26040	broad.mit.edu	37	18	42531860	42531860	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr18:42531860C>T	uc010dni.2	+	4	2851	c.2555C>T	c.(2554-2556)ACG>ATG	p.T852M		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	852						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGGAAATCACGCTGTCCCCT	0.562000									Schinzel-Giedion_syndrome				13	49					0	0	0.013537	0	0	
PLIN4	729359	broad.mit.edu	37	19	4510934	4510934	+	Missense_Mutation	SNP	T	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:4510934T>G	uc002mar.1	-	3	2996	c.2996A>C	c.(2995-2997)CAG>CCG	p.Q999P	PLIN4_uc010dub.1_Missense_Mutation_p.Q23P	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	999						lipid particle|plasma membrane					0						CAGGCCCCCCTGGACGGCCCC	0.642000													11	77					0	0	0.013537	0	0	
SMARCA4	6597	broad.mit.edu	37	19	11134252	11134252	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:11134252G>A	uc002mqf.3	+	20	3202	c.2918G>A	c.(2917-2919)CGG>CAG	p.R973Q	SMARCA4_uc010dxp.2_Missense_Mutation_p.R973Q|SMARCA4_uc010dxo.2_Missense_Mutation_p.R973Q|SMARCA4_uc002mqg.1_Missense_Mutation_p.R973Q|SMARCA4_uc010dxq.2_Missense_Mutation_p.R973Q|SMARCA4_uc010dxr.2_Missense_Mutation_p.R973Q|SMARCA4_uc002mqj.3_Missense_Mutation_p.R973Q|SMARCA4_uc010dxs.2_Missense_Mutation_p.R973Q|SMARCA4_uc010dxt.1_Missense_Mutation_p.R193Q|SMARCA4_uc002mqh.3_Missense_Mutation_p.R96Q|SMARCA4_uc002mqi.1_Missense_Mutation_p.R176Q	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	973					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AAAGTGCTGCGGCCCTTCTTG	0.562000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				22	4					0	0	0.018920	0	0	
EMR2	30817	broad.mit.edu	37	19	14862365	14862365	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:14862365T>C	uc002mzp.1	-	16	2363	c.1907A>G	c.(1906-1908)TAC>TGC	p.Y636C	EMR2_uc010dzs.1_Missense_Mutation_p.Y95C|EMR2_uc010xnw.1_Missense_Mutation_p.Y578C|EMR2_uc002mzo.1_Missense_Mutation_p.Y625C|EMR2_uc002mzq.1_Missense_Mutation_p.Y576C|EMR2_uc002mzr.1_Missense_Mutation_p.Y587C|EMR2_uc002mzs.1_Missense_Mutation_p.Y494C|EMR2_uc002mzt.1_Missense_Mutation_p.Y532C|EMR2_uc002mzu.1_Missense_Mutation_p.Y543C|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	636	Cytoplasmic (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GATGCTTGAGTAGTTGACCAC	0.562000													81	70					0	0	0.014410	0	0	
IL12RB1	3594	broad.mit.edu	37	19	18179266	18179266	+	Silent	SNP	G	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:18179266G>C	uc002nhw.1	-	11	1324	c.1260C>G	c.(1258-1260)GCC>GCG	p.A420A	IL12RB1_uc010xqb.1_Silent_p.A420A|IL12RB1_uc002nhx.1_Silent_p.A460A	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	420	Extracellular (Potential).|Fibronectin type-III 4.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GGTGCGCAGAGGCAAAGATGG	0.522000													12	152					0	0	0.013537	0	0	
ZNF492	57615	broad.mit.edu	37	19	22847938	22847938	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:22847938C>T	uc002nqw.3	+	4	1711	c.1467C>T	c.(1465-1467)TCC>TCT	p.S489S		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	489	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TTAACAACTCCTCTATTCTTA	0.368000													16	7					0	0	0.012319	0	0	
ZNF569	148266	broad.mit.edu	37	19	37903672	37903672	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:37903672C>T	uc002ogi.2	-	6	2446	c.1888G>A	c.(1888-1890)GGT>AGT	p.G630S	ZNF569_uc002ogh.2_Missense_Mutation_p.G471S|ZNF569_uc002ogj.2_Missense_Mutation_p.G654S	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	630					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTTTCTCACCTGTATGTCCT	0.408000													9	75					0	0	0.004482	0	0	
NUMBL	9253	broad.mit.edu	37	19	41188680	41188680	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:41188680G>A	uc002oon.2	-	5	520	c.352C>T	c.(352-354)CTG>TTG	p.L118L	NUMBL_uc010xvq.1_Silent_p.L77L|NUMBL_uc002ooo.2_Silent_p.L118L|NUMBL_uc010xvr.1_Silent_p.L77L	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	118	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			GACACCCACAGGACAGACTTC	0.647000													27	42					0	0	0.006320	0	0	
IRF2BP1	26145	broad.mit.edu	37	19	46388028	46388028	+	Silent	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:46388028G>T	uc002pds.1	-	1	1349	c.1005C>A	c.(1003-1005)ACC>ACA	p.T335T		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		GGACGCCGTCGGTAAGCAGCT	0.692000													11	36					1.61879e-10	1.71883e-10	0.013537	1	0	
LILRA3	11026	broad.mit.edu	37	19	54803070	54803070	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr19:54803070G>A	uc002qfd.2	-	4	672	c.607C>T	c.(607-609)CGC>TGC	p.R203C	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	203	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TAGGGAGCGCGCGAGTCATAA	0.612000													134	43					0	0	0.014410	0	0	
GREB1	9687	broad.mit.edu	37	2	11750887	11750887	+	Missense_Mutation	SNP	G	A	A	rs139446036	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:11750887G>A	uc002rbk.1	+	18	3040	c.2740G>A	c.(2740-2742)GTA>ATA	p.V914I	GREB1_uc002rbo.1_Missense_Mutation_p.V548I|GREB1_uc002rbp.1_5'Flank	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	914						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCTGATGGCCGTAAGCGGCCT	0.632000													71	110					0	0	0.014410	0	0	
OTOF	9381	broad.mit.edu	37	2	26684574	26684574	+	Silent	SNP	G	A	A	rs145894536	byFrequency	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:26684574G>A	uc002rhk.2	-	43	5650	c.5523C>T	c.(5521-5523)GAC>GAT	p.D1841D	OTOF_uc010yla.1_Silent_p.D571D|OTOF_uc002rhh.2_Silent_p.D1074D|OTOF_uc002rhi.2_Silent_p.D1151D|OTOF_uc002rhj.2_Silent_p.D1074D	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1841	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGGAAGTCGTCAGCGGAGA	0.632000													73	33					0	0	0.014410	0	0	
OTOF	9381	broad.mit.edu	37	2	26702140	26702140	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:26702140C>T	uc002rhk.2	-	18	2333	c.2206G>A	c.(2206-2208)GAC>AAC	p.D736N	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	736	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCAGCTTGTCGGCAATGTGG	0.642000													5	24					0	0	0.001984	0	0	
OTOF	9381	broad.mit.edu	37	2	26712138	26712138	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:26712138C>T	uc002rhk.2	-	11	1113	c.986G>A	c.(985-987)CGC>CAC	p.R329H		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	329	Cytoplasmic (Potential).|C2 1.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGCCACTGCGCAGCAGGTT	0.617000													30	13					0	0	0.007291	0	0	
XDH	7498	broad.mit.edu	37	2	31595105	31595105	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:31595105G>A	uc002rnv.1	-	17	1924	c.1845C>T	c.(1843-1845)CAC>CAT	p.H615H		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	615					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGATCTTGGCGTGGGCCCGGG	0.617000													41	205					0	0	0.011902	0	0	
MSH2	4436	broad.mit.edu	37	2	47639634	47639634	+	Missense_Mutation	SNP	C	T	T	rs138857091		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:47639634C>T	uc002rvy.1	+	4	795	c.727C>T	c.(727-729)CGG>TGG	p.R243W	MSH2_uc010yoh.1_Missense_Mutation_p.R177W|MSH2_uc002rvz.2_Missense_Mutation_p.R243W|MSH2_uc010fbg.2_Missense_Mutation_p.R103W|MSH2_uc010fbf.1_Missense_Mutation_p.R150W	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	243					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding			large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGACCTCAACCGGTTGTTGAA	0.338000			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				19	14					0	0	0.008871	0	0	
LRRTM1	347730	broad.mit.edu	37	2	80530432	80530432	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:80530432G>A	uc002sok.1	-	2	783	c.513C>T	c.(511-513)AAC>AAT	p.N171N	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	171	LRR 4.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ACTGGATGGCGTTGGCCCGCA	0.612000										HNSCC(69;0.2)			30	56					0	0	0.006320	0	0	
GPR45	11250	broad.mit.edu	37	2	105859311	105859311	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:105859311C>T	uc002tco.1	+	1	1112	c.996C>T	c.(994-996)CGC>CGT	p.R332R		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AAAAATTCCGCGAGGCCTGCA	0.552000													110	138					0	0	0.014410	0	0	
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	G	G	rs115341812	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567000													5	43					0	0	0.014758	0	0	
NEB	4703	broad.mit.edu	37	2	152521048	152521048	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:152521048C>T	uc010fnx.2	-	44	5609	c.5418G>A	c.(5416-5418)AAG>AAA	p.K1806K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1806	Nebulin 47.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCTTGCAGCCTTTATTGCAA	0.428000													6	4					0	0	0.001168	0	0	
TTN	7273	broad.mit.edu	37	2	179472320	179472320	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:179472320G>A	uc010zfg.1	-	226	45615	c.45391C>T	c.(45391-45393)CGC>TGC	p.R15131C	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8826C|TTN_uc010zfi.1_Missense_Mutation_p.R8759C|TTN_uc010zfj.1_Missense_Mutation_p.R8634C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16058							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R8634C(1)|p.R15131C(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTACAGGGCGACCAGTCACC	0.443000													37	163					0	0	0.021022	0	0	
TTN	7273	broad.mit.edu	37	2	179483531	179483531	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:179483531G>A	uc010zfg.1	-	200	39266	c.39042C>T	c.(39040-39042)GGC>GGT	p.G13014G	TTN_uc010zfh.1_Silent_p.G6709G|TTN_uc010zfi.1_Silent_p.G6642G|TTN_uc010zfj.1_Silent_p.G6517G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13941							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGAGGCTTGCCAACATCAA	0.413000													6	26					0	0	0.001168	0	0	
TTN	7273	broad.mit.edu	37	2	179501304	179501304	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:179501304G>T	uc010zfg.1	-	174	33670	c.33446C>A	c.(33445-33447)ACA>AAA	p.T11149K	TTN_uc010zfh.1_Missense_Mutation_p.T4844K|TTN_uc010zfi.1_Missense_Mutation_p.T4777K|TTN_uc010zfj.1_Missense_Mutation_p.T4652K|TTN_uc010fre.1_Missense_Mutation_p.T1010K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12076							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCCAGGTTGTAATTGCAGT	0.413000													13	54					6.81908e-15	7.44974e-15	0.020292	1	0	
TNS1	7145	broad.mit.edu	37	2	218700881	218700881	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:218700881G>A	uc002vgt.2	-	18	3084	c.2686C>T	c.(2686-2688)CGG>TGG	p.R896W	TNS1_uc002vgr.2_Missense_Mutation_p.R896W|TNS1_uc002vgs.2_Missense_Mutation_p.R896W|TNS1_uc010zjv.1_Missense_Mutation_p.R896W	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	896						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CTGGCCGCCCGCCTCCGCAGA	0.617000													20	88					0	0	0.008871	0	0	
STK36	27148	broad.mit.edu	37	2	219558685	219558685	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:219558685G>A	uc002viu.2	+	19	2581	c.2315G>A	c.(2314-2316)CGG>CAG	p.R772Q	STK36_uc002viv.2_Missense_Mutation_p.R772Q|STK36_uc002viw.2_5'Flank|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	772					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTTGTCTTTCGGCTCCAAAAC	0.438000													31	41					0	0	0.012213	0	0	
DOCK10	55619	broad.mit.edu	37	2	225669928	225669928	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:225669928G>A	uc010fwz.1	-	36	4285	c.4046C>T	c.(4045-4047)TCG>TTG	p.S1349L	DOCK10_uc002vob.2_Missense_Mutation_p.S1343L|DOCK10_uc002voa.2_Missense_Mutation_p.S5L|DOCK10_uc002voc.2_Missense_Mutation_p.S203L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1349							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TTTACCGTACGAAATCGTTTT	0.363000													15	73					0	0	0.020292	0	0	
COL6A3	1293	broad.mit.edu	37	2	238259791	238259791	+	Silent	SNP	G	A	A	rs116541926	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:238259791G>A	uc002vwl.2	-	27	7083	c.6798C>T	c.(6796-6798)ACC>ACT	p.T2266T	COL6A3_uc002vwo.2_Silent_p.T2060T|COL6A3_uc010znj.1_Silent_p.T1659T|COL6A3_uc002vwp.1_Silent_p.T87T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2266	Triple-helical region.|Collagen-like 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCAGTGGACCGGTTCTGCCTC	0.577000													49	77					0	0	0.014410	0	0	
AQP12B	653437	broad.mit.edu	37	2	241622318	241622318	+	Splice_Site	SNP	C	T	T	rs139037294	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr2:241622318C>T	uc010fzj.2	-	1	1	c.-62_splice	c.e1-1		AQP12B_uc002vzt.2_RNA	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B							integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		AGGAGCTGGCCGGTTCCCACA	0.672000													3	20					0	0	0.009096	0	0	
TPX2	22974	broad.mit.edu	37	20	30371652	30371652	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:30371652G>T	uc002wwp.1	+	12	2039	c.1341G>T	c.(1339-1341)AAG>AAT	p.K447N	TPX2_uc010gdv.1_Missense_Mutation_p.K483N	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	447					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GAGAATCAAAGAAGAAAACAG	0.453000													33	137					2.61193e-14	2.8371e-14	0.009535	1	0	
SLC32A1	140679	broad.mit.edu	37	20	37356300	37356300	+	Missense_Mutation	SNP	C	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:37356300C>G	uc002xjc.2	+	2	859	c.596C>G	c.(595-597)CCA>CGA	p.P199R		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	199	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CCGCGCTTCCCAACGCTGGGC	0.627000													48	62					0	0	0.014410	0	0	
SEMG1	6406	broad.mit.edu	37	20	43837007	43837007	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:43837007C>T	uc002xni.2	+	2	1126	c.1069C>T	c.(1069-1071)CGA>TGA	p.R357*	SEMG1_uc002xnj.2_Nonsense_Mutation_p.R297*|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	357	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				GGAAGAAAGACGACTCCACTA	0.413000													21	42					0	0	0.012319	0	0	
CSTF1	1477	broad.mit.edu	37	20	54972832	54972832	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:54972832G>A	uc002xxl.1	+	4	780	c.580G>A	c.(580-582)GAT>AAT	p.D194N	CSTF1_uc002xxm.1_Missense_Mutation_p.D194N|CSTF1_uc002xxn.1_Missense_Mutation_p.D194N|CSTF1_uc002xxo.1_Missense_Mutation_p.D137N	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	194	WD 2.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			TGGTTCAAGGGATTATACTCT	0.393000													6	84					0	0	0.001168	0	0	
CTSZ	1522	broad.mit.edu	37	20	57571768	57571768	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:57571768C>T	uc002yai.2	-	5	853	c.727G>A	c.(727-729)GTT>ATT	p.V243I	CTSZ_uc002yaj.3_Missense_Mutation_p.V243I	NM_001336	NP_001327	Q9UBR2	CATZ_HUMAN	cathepsin Z preproprotein	243					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			kidney(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			GCCACAGAAACGACATGGTTT	0.473000													44	129					0	0	0.010771	0	0	
ZNF831	128611	broad.mit.edu	37	20	57767395	57767395	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:57767395G>A	uc002yan.2	+	1	1321	c.1321G>A	c.(1321-1323)GAC>AAC	p.D441N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	441						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGCAGCATCGACCTGCCCAC	0.677000													36	33					0	0	0.015359	0	0	
CDH4	1002	broad.mit.edu	37	20	60485495	60485495	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:60485495C>T	uc002ybn.1	+	9	1220	c.1206C>T	c.(1204-1206)CCC>CCT	p.P402P	CDH4_uc002ybp.1_Silent_p.P328P	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	402	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGGAGGTCCCCGAAAACCGCG	0.428000													18	85					0	0	0.006122	0	0	
PSMA7	5688	broad.mit.edu	37	20	60714221	60714221	+	Silent	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:60714221A>G	uc002ybx.1	-	4	496	c.381T>C	c.(379-381)TTT>TTC	p.F127F	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	127					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CAGAGATGCCAAACGGCCTGC	0.512000													82	110					0	0	0.014410	0	0	
C20orf135	140701	broad.mit.edu	37	20	62493709	62493709	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:62493709C>T	uc002ygx.1	+	1	1144	c.816C>T	c.(814-816)TTC>TTT	p.F272F	TPD52L2_uc002ygy.2_5'Flank|TPD52L2_uc002ygz.2_5'Flank|TPD52L2_uc002yha.2_5'Flank|TPD52L2_uc002yhb.2_5'Flank|TPD52L2_uc002yhc.2_5'Flank|TPD52L2_uc002yhd.2_5'Flank|TPD52L2_uc011abk.1_5'Flank|TPD52L2_uc011abl.1_5'Flank	NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	272							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					ACGCCACCTTCGACGACCTTG	0.667000													21	29					0	0	0.018920	0	0	
SMTN	6525	broad.mit.edu	37	22	31495818	31495818	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr22:31495818G>A	uc003ajl.1	+	19	2757	c.2539G>A	c.(2539-2541)GAC>AAC	p.D847N	SMTN_uc003ajk.1_Missense_Mutation_p.D847N|SMTN_uc003ajm.1_Missense_Mutation_p.D847N|SMTN_uc011ale.1_Missense_Mutation_p.D932N|SMTN_uc011alf.1_Missense_Mutation_p.D903N|SMTN_uc003ajn.1_Missense_Mutation_p.D870N|SMTN_uc011alg.1_Missense_Mutation_p.D303N|SMTN_uc003ajo.1_Missense_Mutation_p.D370N|SMTN_uc010gwe.1_Missense_Mutation_p.D227N|SMTN_uc003ajp.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	847	CH.				muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						TGAGGCCTTCGACTATGGGCA	0.572000													18	44					0	0	0.004990	0	0	
SEMA3F	6405	broad.mit.edu	37	3	50224175	50224175	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr3:50224175G>A	uc003cyj.2	+	18	2141	c.1943G>A	c.(1942-1944)CGA>CAA	p.R648Q	SEMA3F_uc003cyk.2_Missense_Mutation_p.R617Q	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	648	Ig-like C2-type.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GACCGGCGCCGAGAGGTGAGT	0.612000													4	22					0	0	0.009096	0	0	
FLNB	2317	broad.mit.edu	37	3	58064475	58064475	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr3:58064475G>A	uc003djj.2	+	3	738	c.573G>A	c.(571-573)CCG>CCA	p.P191P	FLNB_uc010hne.2_Silent_p.P191P|FLNB_uc003djk.2_Silent_p.P191P|FLNB_uc010hnf.2_Silent_p.P191P|FLNB_uc003djl.2_Silent_p.P22P|FLNB_uc003djm.2_Silent_p.P22P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	191	CH 2.|Actin-binding.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCTGGGACCCGCAGAAGCCTG	0.517000													8	14					0	0	0.006214	0	0	
PLCXD2	257068	broad.mit.edu	37	3	111432935	111432935	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr3:111432935C>T	uc003dya.2	+	3	1412	c.826C>T	c.(826-828)CGG>TGG	p.R276W	PLCXD2_uc003dyb.2_Missense_Mutation_p.R276W|PLCXD2_uc003dxz.2_Missense_Mutation_p.R276W	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	276					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						GACCATTGCCCGGGGCTTGGT	0.502000													22	29					0	0	0.014323	0	0	
CLSTN2	64084	broad.mit.edu	37	3	140281655	140281655	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr3:140281655G>A	uc003etn.2	+	14	2405	c.2215G>A	c.(2215-2217)GTG>ATG	p.V739M		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	739	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGGCACAGGTGTGGGCTCCAT	0.572000										HNSCC(16;0.037)			24	34					0	0	0.021523	0	0	
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587000													3	24					0	0	0.004672	0	0	
ACOX3	8310	broad.mit.edu	37	4	8401309	8401309	+	Missense_Mutation	SNP	C	T	T	rs142830697		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr4:8401309C>T	uc010idk.2	-	8	992	c.847G>A	c.(847-849)GAG>AAG	p.E283K	ACOX3_uc003glc.3_Missense_Mutation_p.E283K|ACOX3_uc003gld.3_Missense_Mutation_p.E283K|ACOX3_uc003gle.1_Missense_Mutation_p.E188K	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	283					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						TAGGTGCCCTCGGGGGTGACG	0.607000													16	61					0	0	0.007413	0	0	
DRD5	1816	broad.mit.edu	37	4	9783986	9783986	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr4:9783986G>A	uc003gmb.3	+	1	729	c.333G>A	c.(331-333)GCG>GCA	p.A111A		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	111	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCTTTGGAGCGTTCTGCGACG	0.617000													13	50					0	0	0.016723	0	0	
GRID2	2895	broad.mit.edu	37	4	93225854	93225854	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr4:93225854G>A	uc011cdt.1	+	1	305	c.47G>A	c.(46-48)CGA>CAA	p.R16Q	GRID2_uc010ikx.2_Missense_Mutation_p.R16Q|GRID2_uc011cdu.1_Missense_Mutation_p.R16Q	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	16					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGTGGTCTCGAACCTGGGAC	0.443000													13	40					0	0	0.016723	0	0	
ANK2	287	broad.mit.edu	37	4	114254239	114254239	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr4:114254239C>T	uc003ibe.3	+	29	3354	c.3254C>T	c.(3253-3255)GCG>GTG	p.A1085V	ANK2_uc003ibd.3_Missense_Mutation_p.A1076V|ANK2_uc003ibf.3_Missense_Mutation_p.A1085V|ANK2_uc011cgc.1_Missense_Mutation_p.A261V|ANK2_uc003ibg.3_Missense_Mutation_p.A80V|ANK2_uc003ibc.2_Missense_Mutation_p.A1061V|ANK2_uc011cgb.1_Missense_Mutation_p.A1100V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1052	ZU5.|Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCTCACTTTGCGGCCCTTCGA	0.502000													52	55					0	0	0.014410	0	0	
KIAA1109	84162	broad.mit.edu	37	4	123252601	123252601	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr4:123252601C>T	uc003ieh.2	+	65	11415	c.11370C>T	c.(11368-11370)GAC>GAT	p.D3790D	KIAA1109_uc003iem.2_Silent_p.D181D	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3790					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GAAATATTGACTTTGAACTTG	0.408000													5	13					0	0	0.014758	0	0	
IRX1	79192	broad.mit.edu	37	5	3600242	3600242	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:3600242G>A	uc003jde.2	+	2	1232	c.1180G>A	c.(1180-1182)GTT>ATT	p.V394I		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	394						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CTTCCTGGGCGTTGGCGCTCC	0.657000													43	21					0	0	0.014410	0	0	
IL6ST	3572	broad.mit.edu	37	5	55237554	55237554	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:55237554G>A	uc003jqq.2	-	17	2368	c.2113C>T	c.(2113-2115)CCA>TCA	p.P705S	uc003jqp.2_5'Flank|IL6ST_uc010iwb.2_Missense_Mutation_p.P644S|IL6ST_uc010iwc.2_3'UTR|IL6ST_uc010iwd.2_Missense_Mutation_p.P24S|IL6ST_uc011cqk.1_Missense_Mutation_p.P416S|IL6ST_uc003jqr.2_3'UTR	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	705	Cytoplasmic (Potential).				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AGATCTTCTGGAAAAGGCTTT	0.358000			O		hepatocellular ca								7	79					0	0	0.001984	0	0	
VCAN	1462	broad.mit.edu	37	5	82836187	82836187	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:82836187C>A	uc003kii.3	+	8	7721	c.7365C>A	c.(7363-7365)AGC>AGA	p.S2455R	VCAN_uc003kij.3_Missense_Mutation_p.S1468R|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.S1119R	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2455	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GACAAGAAAGCAGCACCACAT	0.448000													42	26					4.67007e-22	5.19201e-22	0.008740	1	0	
VCAN	1462	broad.mit.edu	37	5	82836404	82836404	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:82836404G>A	uc003kii.3	+	8	7938	c.7582G>A	c.(7582-7584)GAG>AAG	p.E2528K	VCAN_uc003kij.3_Missense_Mutation_p.E1541K|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.E1192K	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2528	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGGGAATTCGAGGATTCCAC	0.408000													31	12					0	0	0.009535	0	0	
DMXL1	1657	broad.mit.edu	37	5	118533640	118533640	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:118533640C>T	uc003ksd.2	+	32	7915	c.7734C>T	c.(7732-7734)AAC>AAT	p.N2578N	DMXL1_uc010jcl.1_Silent_p.N2578N	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2578										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AACCTACAAACACTCCTTTCA	0.308000													16	107					0	0	0.003163	0	0	
ZNF474	133923	broad.mit.edu	37	5	121488536	121488536	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:121488536T>C	uc003ksv.2	+	2	1227	c.851T>C	c.(850-852)CTT>CCT	p.L284P		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	284						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		CAAGCTCAGCTTGTGTTCTGC	0.527000													14	70					0	0	0.016723	0	0	
NEUROG1	4762	broad.mit.edu	37	5	134871035	134871035	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:134871035G>A	uc003lax.2	-	1	605	c.346C>T	c.(346-348)CGC>TGC	p.R116C		NM_006161	NP_006152	Q92886	NGN1_HUMAN	neurogenin 1	116	Helix-loop-helix motif.				positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCACGCTGCGCAGTGCGTCC	0.657000													5	25					0	0	0.014758	0	0	
PCDHB3	56132	broad.mit.edu	37	5	140482078	140482078	+	Silent	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:140482078C>T	uc003lio.2	+	1	1845	c.1845C>T	c.(1843-1845)TTC>TTT	p.F615F	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	615	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCTGTTCGGCGTGTGGG	0.692000													12	169					0	0	0.016723	0	0	
C1QTNF2	114898	broad.mit.edu	37	5	159776631	159776631	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr5:159776631C>A	uc003lyd.2	-	3	541	c.537G>T	c.(535-537)GAG>GAT	p.E179D		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	134	Collagen-like.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAGGCCTGGCTCCCCCTTCT	0.677000													41	239					1.8453e-21	2.03954e-21	0.010771	1	0	
RNF182	221687	broad.mit.edu	37	6	13977379	13977379	+	Missense_Mutation	SNP	C	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:13977379C>T	uc003nbe.2	+	3	447	c.29C>T	c.(28-30)GCG>GTG	p.A10V	RNF182_uc003nbf.2_Missense_Mutation_p.A10V|RNF182_uc003nbg.2_Missense_Mutation_p.A10V	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	10						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			GAAGACACTGCGGAGTCTCAG	0.468000													24	100					0	0	0.018920	0	0	
BTN1A1	696	broad.mit.edu	37	6	26501921	26501921	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:26501921G>T	uc003nif.3	+	2	203	c.183G>T	c.(181-183)TTG>TTT	p.L61F		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	61	Extracellular (Potential).|Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						CCGAGCACTTGGAGCTACGCT	0.677000													5	57					0.00116845	0.00118094	0.001168	1	0	
SCAND3	114821	broad.mit.edu	37	6	28543893	28543893	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:28543893T>C	uc003nlo.2	-	3	1207	c.589A>G	c.(589-591)ATG>GTG	p.M197V		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	197					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGAGACATCATGGAAAACCAC	0.333000													6	20					0	0	0.001168	0	0	
GRM4	2914	broad.mit.edu	37	6	34004261	34004261	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:34004261G>A	uc003oir.3	-	8	1796	c.1626C>T	c.(1624-1626)TGC>TGT	p.C542C	GRM4_uc011dsn.1_Silent_p.C495C|GRM4_uc010jvh.2_Silent_p.C542C|GRM4_uc010jvi.2_Silent_p.C234C|GRM4_uc003oio.2_Silent_p.C234C|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.C402C|GRM4_uc003oiq.2_Silent_p.C409C|GRM4_uc011dsm.1_Silent_p.C373C	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	542	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TGCAAGGCTCGCAGTGCCAGC	0.657000													39	33					0	0	0.006999	0	0	
SYNE1	23345	broad.mit.edu	37	6	152563500	152563500	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:152563500G>A	uc010kiw.2	-	107	20370	c.19768C>T	c.(19768-19770)CAG>TAG	p.Q6590*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.Q1114*|SYNE1_uc003qos.3_Nonsense_Mutation_p.Q1114*|SYNE1_uc003qot.3_Nonsense_Mutation_p.Q6519*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q6590*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6590	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTCATACTGACTCTTGAGT	0.478000										HNSCC(10;0.0054)			20	74					0	0	0.008871	0	0	
MYCT1	80177	broad.mit.edu	37	6	153043291	153043291	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:153043291G>A	uc003qpd.3	+	2	619	c.611G>A	c.(610-612)CGT>CAT	p.R204H	MYCT1_uc010kjc.1_Missense_Mutation_p.R156H|MYCT1_uc003qpc.3_Missense_Mutation_p.R204H	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	204						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		AGTCTGAGCCGTCCTGACTAC	0.532000													20	83					0	0	0.008871	0	0	
FNDC1	84624	broad.mit.edu	37	6	159677562	159677562	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr6:159677562G>T	uc010kjv.2	+	18	5273	c.5073G>T	c.(5071-5073)TTG>TTT	p.L1691F		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1691	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAGGTTACTTGGTTTACAGTG	0.458000													20	70					4.96729e-08	5.21565e-08	0.008871	1	0	
DPY19L2P1	554236	broad.mit.edu	37	7	35131484	35131484	+	Missense_Mutation	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:35131484G>T	uc003teq.1	-	20	2209	c.1102C>A	c.(1102-1104)CCA>ACA	p.P368T	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						TCGTAAAGTGGATGATTCACA	0.413000													11	55					1.61879e-10	1.71883e-10	0.013537	1	0	
POM121	9883	broad.mit.edu	37	7	72418975	72418975	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:72418975G>A	uc010lam.1	+	16	4007	c.2966G>A	c.(2965-2967)GGA>GAA	p.G989E	NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_Missense_Mutation_p.S275F|NSUN5P2_uc003twn.2_Missense_Mutation_p.S299F|NSUN5P2_uc003two.2_Missense_Mutation_p.S299F|NSUN5P2_uc003twq.2_3'UTR|NSUN5P2_uc010lan.1_3'UTR|NSUN5P2_uc003twp.2_3'UTR	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	Error:Variant_position_missing_in_Q96HA1_after_alignment					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CCACGGAGAGGACAGGCATCT	0.572000													24	178					0	0	0.016522	0	0	
MAGI2	9863	broad.mit.edu	37	7	77789454	77789454	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:77789454G>A	uc003ugx.2	-	16	2987	c.2733C>T	c.(2731-2733)TTC>TTT	p.F911F	MAGI2_uc003ugy.2_Silent_p.F897F|MAGI2_uc010ldx.1_Silent_p.F504F	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	911						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGTGGGAGGCGAAGCCTTCAG	0.577000													25	65					0	0	0.018920	0	0	
SEMA3C	10512	broad.mit.edu	37	7	80432050	80432050	+	Missense_Mutation	SNP	A	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:80432050A>C	uc003uhj.2	-	9	1409	c.847T>G	c.(847-849)TTC>GTC	p.F283V	SEMA3C_uc011kgw.1_Missense_Mutation_p.F301V|SEMA3C_uc011kgx.1_Missense_Mutation_p.F135V	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	283	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						GCCTTTAAGAAAGTGGTCCAC	0.393000													22	69					0	0	0.014323	0	0	
RELN	5649	broad.mit.edu	37	7	103234184	103234184	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:103234184C>A	uc003vca.2	-	27	4017	c.3857G>T	c.(3856-3858)CGA>CTA	p.R1286L	RELN_uc010liz.2_Missense_Mutation_p.R1286L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1286					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TACTGCAAATCGATCTCCATC	0.403000													5	83					0.000602214	0.000615235	0.014758	1	0	
SLC26A4	5172	broad.mit.edu	37	7	107334909	107334909	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:107334909T>C	uc003vep.2	+	11	1549	c.1325T>C	c.(1324-1326)CTG>CCG	p.L442P	SLC26A4_uc011kmb.1_Missense_Mutation_p.L29P|SLC26A4_uc011kmc.1_Intron|SLC26A4_uc011kmd.1_Missense_Mutation_p.L11P	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	442	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GGGAAGCTTCTGGAACCCTTG	0.458000									Pendred_syndrome				39	39					0	0	0.005524	0	0	
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507000													25	62					0	0	0.014410	0	0	
FLNC	2318	broad.mit.edu	37	7	128494556	128494556	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr7:128494556G>A	uc003vnz.3	+	41	7026	c.6817G>A	c.(6817-6819)GCC>ACC	p.A2273T	FLNC_uc003voa.3_Missense_Mutation_p.A2240T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2273	Filamin 20.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CGAGGACAGCGCCTACAGCGT	0.632000													16	16					0	0	0.003163	0	0	
MAK16	84549	broad.mit.edu	37	8	33353133	33353133	+	Missense_Mutation	SNP	C	T	T	rs150362163		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr8:33353133C>T	uc003xjj.2	+	7	561	c.521C>T	c.(520-522)ACG>ATG	p.T174M	C8orf41_uc010lvu.1_Intron	NM_032509	NP_115898	Q9BXY0	MAK16_HUMAN	MAK16 homolog	174						nucleolus				ovary(1)	1						AAACAAGATACGGTGAGAAAG	0.343000													14	45					0	0	0.003163	0	0	
GRHL2	79977	broad.mit.edu	37	8	102570941	102570941	+	Silent	SNP	C	T	T	rs144668624		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr8:102570941C>T	uc010mbu.2	+	4	909	c.579C>T	c.(577-579)GAC>GAT	p.D193D	GRHL2_uc011lhi.1_Silent_p.D193D	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	193						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CTCAGTATGACGTGCCCTCGC	0.567000													27	112					0	0	0.005443	0	0	
SYBU	55638	broad.mit.edu	37	8	110588230	110588230	+	Silent	SNP	G	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr8:110588230G>T	uc003ynj.3	-	7	1060	c.897C>A	c.(895-897)ATC>ATA	p.I299I	SYBU_uc003yni.3_Silent_p.I296I|SYBU_uc003ynk.3_Silent_p.I180I|SYBU_uc010mco.2_Silent_p.I298I|SYBU_uc003ynl.3_Silent_p.I298I|SYBU_uc010mcp.2_Silent_p.I299I|SYBU_uc010mcq.2_Silent_p.I299I|SYBU_uc003yno.3_Silent_p.I180I|SYBU_uc010mcr.2_Silent_p.I299I|SYBU_uc003ynm.3_Silent_p.I298I|SYBU_uc003ynn.3_Silent_p.I298I|SYBU_uc010mcs.2_Silent_p.I180I|SYBU_uc010mct.2_Silent_p.I299I|SYBU_uc010mcu.2_Silent_p.I298I|SYBU_uc003ynp.3_Silent_p.I231I|SYBU_uc010mcv.2_Silent_p.I299I|SYBU_uc003ynh.3_Silent_p.I93I|SYBU_uc011lhw.1_Silent_p.I169I	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	299	Potential.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TAAGCTCCACGATTTCACTTT	0.463000													12	101					0.000978159	0.000993936	0.010729	1	0	
ADCY8	114	broad.mit.edu	37	8	131793086	131793086	+	Silent	SNP	G	A	A	rs145809062		TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr8:131793086G>A	uc003ytd.3	-	18	3562	c.3306C>T	c.(3304-3306)GGC>GGT	p.G1102G	ADCY8_uc010mds.2_Silent_p.G971G	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1102	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTTTCTTAGCGCCGATAACGC	0.567000										HNSCC(32;0.087)			72	255					0	0	0.014410	0	0	
TG	7038	broad.mit.edu	37	8	133882060	133882060	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr8:133882060G>A	uc003ytw.2	+	3	304	c.263G>A	c.(262-264)CGG>CAG	p.R88Q		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	88	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGCCAGGACGGCCTGTGGCT	0.622000													19	90					0	0	0.006122	0	0	
RANBP6	26953	broad.mit.edu	37	9	6015438	6015438	+	Missense_Mutation	SNP	A	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:6015438A>G	uc003zjr.2	-	1	181	c.170T>C	c.(169-171)GTC>GCC	p.V57A	RANBP6_uc011lmf.1_Missense_Mutation_p.V57A|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	57					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TCTATTTCTGACGGCATCTAA	0.473000													22	51					0	0	0.010504	0	0	
ANKRD19	138649	broad.mit.edu	37	9	95599848	95599848	+	RNA	SNP	C	T	T	rs3824428	by1000genomes	TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:95599848C>T	uc004ass.2	+	9		c.1932C>T			ANKRD19_uc004asr.3_RNA	NR_026868				Homo sapiens cDNA FLJ36178 fis, clone TESTI2026534.												0						CGGGAGGCACCGGCCACAGGC	0.552000													3	27					0	0	0.004672	0	0	
SVEP1	79987	broad.mit.edu	37	9	113171166	113171166	+	Silent	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:113171166G>A	uc010mtz.2	-	38	7051	c.6714C>T	c.(6712-6714)GTC>GTT	p.V2238V	SVEP1_uc010mty.2_Silent_p.V164V	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2238	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CAGGACTTCCGACTGACTTAT	0.502000													28	109					0	0	0.005443	0	0	
MUSK	4593	broad.mit.edu	37	9	113562732	113562732	+	Missense_Mutation	SNP	C	G	G			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:113562732C>G	uc004bey.2	+	14	2172	c.2074C>G	c.(2074-2076)CCT>GCT	p.P692A	MUSK_uc004bez.1_Missense_Mutation_p.P272A	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	692	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						GGTCTCCAGCCCTGGGCCCCC	0.587000													22	182					0	0	0.014323	0	0	
COL27A1	85301	broad.mit.edu	37	9	117051000	117051000	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:117051000G>A	uc011lxl.1	+	43	4063	c.4063G>A	c.(4063-4065)GGA>AGA	p.G1355R	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1355	Collagen-like 12.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GGGTGATCGAGGAGACCGCGG	0.612000													25	21					0	0	0.005443	0	0	
PTGS1	5742	broad.mit.edu	37	9	125154794	125154794	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:125154794G>A	uc004bmg.1	+	11	1906	c.1771G>A	c.(1771-1773)GCT>ACT	p.A591T	PTGS1_uc011lys.1_Missense_Mutation_p.A529T|PTGS1_uc010mwb.1_Missense_Mutation_p.A445T|PTGS1_uc004bmf.1_Missense_Mutation_p.A554T|PTGS1_uc004bmh.1_Missense_Mutation_p.A482T|PTGS1_uc011lyt.1_Missense_Mutation_p.A482T	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	591					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TGATGGGCCTGCTGTGGAGCG	0.582000													8	54					0	0	0.010729	0	0	
FCN1	2219	broad.mit.edu	37	9	137806261	137806261	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:137806261G>A	uc004cfi.2	-	4	369	c.277C>T	c.(277-279)CGA>TGA	p.R93*		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	93	Collagen-like.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TTCTCTCCTCGGTCTCCTGGA	0.617000													28	47					0	0	0.007291	0	0	
NAP1L2	4674	broad.mit.edu	37	X	72433043	72433043	+	Missense_Mutation	SNP	T	C	C			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chrX:72433043T>C	uc004ebi.2	-	1	1642	c.1286A>G	c.(1285-1287)TAT>TGT	p.Y429C	NAP1L2_uc011mqj.1_Missense_Mutation_p.Y287C	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	429					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					AATTTTGTCATAAATTGCATC	0.358000													6	3					0	0	0.001984	0	0	
CXorf48	54967	broad.mit.edu	37	X	134294425	134294425	+	Missense_Mutation	SNP	C	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chrX:134294425C>A	uc004eyk.1	-	3	991	c.335G>T	c.(334-336)AGA>ATA	p.R112I	CXorf48_uc004eyl.1_Missense_Mutation_p.R112I	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	112											0	Acute lymphoblastic leukemia(192;0.000127)					AATTAAAACTCTGGTTCCTGA	0.328000													12	2					4.3838e-07	4.57756e-07	0.016723	1	0	
PDZD4	57595	broad.mit.edu	37	X	153072792	153072792	+	Missense_Mutation	SNP	G	A	A			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chrX:153072792G>A	uc004fiz.1	-	3	579	c.329C>T	c.(328-330)GCG>GTG	p.A110V	PDZD4_uc004fiy.1_Missense_Mutation_p.A35V|PDZD4_uc004fix.2_Missense_Mutation_p.A14V|PDZD4_uc004fja.1_Missense_Mutation_p.A116V|PDZD4_uc011mze.1_Intron	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	110						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CATAAACTCCGCCGGGTCATA	0.672000													3	24					0	0	0.004672	0	0	
NAPB	63908	broad.mit.edu	37	20	23370595	23370596	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr20:23370595_23370596insT	uc002wta.2	-	7	665_666	c.548_549insA	c.(547-549)GAGfs	p.E183fs	NAPB_uc002wtc.2_Frame_Shift_Ins_p.E89fs|NAPB_uc002wtb.2_Frame_Shift_Ins_p.E187fs|NAPB_uc002wtd.3_RNA|NAPB_uc010zss.1_Frame_Shift_Ins_p.E70fs|NAPB_uc010zst.1_Frame_Shift_Ins_p.E144fs	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	183					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					GCTCATAGATCTCAATGGCTTT	0.376													64	116	---	---	---	---						.
CDKN2A	1029	broad.mit.edu	37	9	21974697	21974697	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FP-8099-01A-11D-2340-08	TCGA-FP-8099-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3586481-ed72-4767-9679-09051e29f925	7cf5b9a5-a93c-4956-bb53-40d2cfea4994	g.chr9:21974697delA	uc003zpk.2	-	1	342	c.130delT	c.(130-132)TACfs	p.Y44fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.Y44fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	44	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.Y44*(3)|p.Y44fs*1(1)|p.Y44fs*76(1)|p.V28_V51del(1)|p.Y44S(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CTCCGACCGTAACTATTCGGT	0.692		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			51	74	---	---	---	---						.
