Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
HIVEP3	59269	broad.mit.edu	37	1	41979398	41979398	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:41979398C>A	uc001cgz.3	-	8	6707	c.5494G>T	c.(5494-5496)GAC>TAC	p.D1832Y	HIVEP3_uc001cha.3_Missense_Mutation_p.D1832Y|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1832	Acidic 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCTTCCGAGTCCTGGAACAGG	0.562													17	53					6.49762e-13	7.26771e-13	0.175082	1	0	
FGGY	55277	broad.mit.edu	37	1	60073530	60073530	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:60073530T>A	uc001czi.3	+	9	1171	c.959T>A	c.(958-960)ATG>AAG	p.M320K	FGGY_uc001czg.2_Missense_Mutation_p.M208K|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.M320K|FGGY_uc001czj.3_Missense_Mutation_p.M319K|FGGY_uc001czk.3_Missense_Mutation_p.M208K|FGGY_uc001czl.3_Missense_Mutation_p.M232K|FGGY_uc001czm.3_Missense_Mutation_p.M21K	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	320					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TTCTCAGCCATGGTACCTGGG	0.438													14	214					0	0	0.146539	0	0	
DOCK7	85440	broad.mit.edu	37	1	63119745	63119745	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:63119745C>T	uc001daq.2	-	3	264	c.230G>A	c.(229-231)CGG>CAG	p.R77Q	DOCK7_uc001dan.2_5'Flank|DOCK7_uc001dao.2_5'Flank|DOCK7_uc001dap.2_Missense_Mutation_p.R77Q|DOCK7_uc009wah.1_Missense_Mutation_p.R77Q	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	77					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AATCAAATCCCGTAAAGGCCC	0.433													56	60					0	0	0.139131	0	0	
SERBP1	26135	broad.mit.edu	37	1	67895811	67895811	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:67895811G>A	uc001ddv.2	-	1	313	c.173C>T	c.(172-174)GCG>GTG	p.A58V	SERBP1_uc001ddx.2_Missense_Mutation_p.A58V|SERBP1_uc001ddy.2_Missense_Mutation_p.A58V|SERBP1_uc001ddw.2_Missense_Mutation_p.A58V	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	58					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						GGTCTGGGCCGCGGCCTGAGC	0.657													70	83					0	0	0.139131	0	0	
TMEM56	148534	broad.mit.edu	37	1	95609526	95609526	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:95609526C>A	uc001drb.2	+	2	360	c.69C>A	c.(67-69)TTC>TTA	p.F23L	RWDD3_uc001drd.3_Missense_Mutation_p.F23L|TMEM56_uc001drc.2_Missense_Mutation_p.F23L	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	23	Helical; (Potential).					integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		AGCTTCTTTTCTACTTTGTAA	0.353													36	93					9.17885e-22	1.03433e-21	0.183431	1	0	
NTNG1	22854	broad.mit.edu	37	1	107691262	107691262	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:107691262T>A	uc001dvh.3	+	2	765	c.47T>A	c.(46-48)GTG>GAG	p.V16E	NTNG1_uc001dvf.3_Missense_Mutation_p.V16E|NTNG1_uc010out.1_Missense_Mutation_p.V16E|NTNG1_uc001dvc.3_Missense_Mutation_p.V16E|NTNG1_uc001dvd.1_Missense_Mutation_p.V16E	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	16					axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		TGGGTTACGGTGTCCTCAGTG	0.418													51	179					0	0	0.139131	0	0	
STXBP3	6814	broad.mit.edu	37	1	109342845	109342845	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:109342845G>A	uc001dvy.2	+	17	1528	c.1453G>A	c.(1453-1455)GCT>ACT	p.A485T	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	485					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TCCTTAGGATGCTATTGATAA	0.358													24	112					0	0	0.116897	0	0	
TCHH	7062	broad.mit.edu	37	1	152081126	152081126	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:152081126G>T	uc001ezp.2	-	2	4567	c.4567C>A	c.(4567-4569)CAG>AAG	p.Q1523K	TCHH_uc009wne.1_Missense_Mutation_p.Q1523K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1523	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGGTGCAGCTGCTGTTCCTCC	0.597													5	77					0.000602214	0.000649531	0.014758	1	0	
FLG2	388698	broad.mit.edu	37	1	152328248	152328248	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:152328248C>T	uc001ezw.3	-	3	2087	c.2014G>A	c.(2014-2016)GTT>ATT	p.V672I	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	672	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAGAAACATGTTGTCCA	0.483													128	334					0	0	0.139131	0	0	
OR10Z1	128368	broad.mit.edu	37	1	158576420	158576420	+	Silent	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:158576420C>A	uc010pio.1	+	1	192	c.192C>A	c.(190-192)TCC>TCA	p.S64S		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTTCCTTTCCTTCCTATCCT	0.522													107	292					4.00015e-43	4.61086e-43	0.139131	1	0	
ALDH9A1	223	broad.mit.edu	37	1	165664521	165664521	+	Silent	SNP	G	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:165664521G>T	uc001gdh.1	-	2	400	c.295C>A	c.(295-297)CGA>AGA	p.R99R	ALDH9A1_uc010pky.1_Silent_p.R5R|ALDH9A1_uc010pkz.1_Silent_p.R89R|ALDH9A1_uc010pla.1_Silent_p.R5R	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	75					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	AAAAGGATTCGGCAACGCTCC	0.398													3	119					0.00909568	0.00974076	0.150653	1	0	
FAM5B	57795	broad.mit.edu	37	1	177250031	177250031	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:177250031G>C	uc001glf.2	+	8	2031	c.1719G>C	c.(1717-1719)CAG>CAC	p.Q573H	FAM5B_uc001glg.2_Missense_Mutation_p.Q468H	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	573						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGTCCTTGCAGATCTGTCTCA	0.567													13	47					0	0	0.105934	0	0	
PTPRC	5788	broad.mit.edu	37	1	198719669	198719669	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:198719669G>T	uc001gur.1	+	29	3295	c.3115G>T	c.(3115-3117)GAG>TAG	p.E1039*	PTPRC_uc001gus.1_Nonsense_Mutation_p.E991*|PTPRC_uc001gut.1_Nonsense_Mutation_p.E878*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1039	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACCACTGAAGGAGACCATTGG	0.418													35	142					6.02846e-25	6.84434e-25	0.183431	1	0	
C1orf116	79098	broad.mit.edu	37	1	207198408	207198408	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:207198408C>T	uc001hfd.2	-	3	366	c.107G>A	c.(106-108)AGT>AAT	p.S36N	C1orf116_uc009xcb.1_Translation_Start_Site	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	36						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					GCTGCTATCACTCTGTTGGGT	0.368													7	44					0	0	0.038147	0	0	
RYR2	6262	broad.mit.edu	37	1	237774171	237774171	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:237774171G>A	uc001hyl.1	+	36	4913	c.4793G>A	c.(4792-4794)AGA>AAA	p.R1598K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1598	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGTGGAGCAGAATGCCCAAC	0.547													13	24					0	0	0.093190	0	0	
MAP1LC3C	440738	broad.mit.edu	37	1	242159615	242159615	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:242159615G>A	uc001hzk.2	-	4	369	c.294C>T	c.(292-294)AGC>AGT	p.S98S		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	98					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCATGGTTGCGCTCATGCTGA	0.567													50	167					0	0	0.139131	0	0	
CEP170	9859	broad.mit.edu	37	1	243328999	243328999	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:243328999C>T	uc001hzs.2	-	13	2671	c.2263G>A	c.(2263-2265)GAG>AAG	p.E755K	CEP170_uc001hzt.2_Missense_Mutation_p.E657K|CEP170_uc001hzu.2_Missense_Mutation_p.E657K|CEP170_uc001hzv.1_Missense_Mutation_p.E133K	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	755						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TGAGCCTCCTCCCTTTGTTCT	0.393													10	278					0	0	0.069234	0	0	
C10orf18	54906	broad.mit.edu	37	10	5789022	5789022	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:5789022C>G	uc001iij.2	+	15	4263	c.3638C>G	c.(3637-3639)ACC>AGC	p.T1213S	C10orf18_uc001iik.2_Missense_Mutation_p.T57S	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1213										ovary(1)|central_nervous_system(1)	2						TCAGCCTCTACCACCTTGGGA	0.468													3	139					0	0	0.115264	0	0	
USP54	159195	broad.mit.edu	37	10	75289641	75289641	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:75289641G>C	uc001juo.2	-	13	1874	c.1857C>G	c.(1855-1857)AGC>AGG	p.S619R	USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.S619R|USP54_uc010qkl.1_Missense_Mutation_p.S619R	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	619					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					AAGGTGGCTTGCTTGGTTCAT	0.468											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	127					0	0	0.139131	0	0	
NDST2	8509	broad.mit.edu	37	10	75567759	75567759	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:75567759T>C	uc001jvk.2	-	3	1192	c.388A>G	c.(388-390)AAT>GAT	p.N130D	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Missense_Mutation_p.N7D|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Missense_Mutation_p.N7D	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	130	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					CCATGGGTATTATCAGTCAAT	0.527													37	115					0	0	0.092188	0	0	
TDRD1	56165	broad.mit.edu	37	10	115970506	115970506	+	Silent	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:115970506C>A	uc001lbg.1	+	12	1704	c.1551C>A	c.(1549-1551)GGC>GGA	p.G517G	TDRD1_uc001lbf.2_Silent_p.G508G|TDRD1_uc001lbh.1_Silent_p.G508G|TDRD1_uc001lbi.1_Silent_p.G508G|TDRD1_uc010qsc.1_Silent_p.G178G|TDRD1_uc001lbj.2_Silent_p.G226G	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	517					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGCAAAGTGGCCGTAAGTCAG	0.363													18	117					5.3912e-06	5.89907e-06	0.175082	1	0	
PDZD8	118987	broad.mit.edu	37	10	119043857	119043857	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:119043857A>C	uc001lde.1	-	5	2586	c.2387T>G	c.(2386-2388)TTG>TGG	p.L796W		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	796					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TCCTTCTTTCAAATATTTGAA	0.373													23	75					0	0	0.062417	0	0	
PPP2R2D	55844	broad.mit.edu	37	10	133757520	133757520	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr10:133757520C>T	uc001lks.2	+	4	670	c.427C>T	c.(427-429)CGA>TGA	p.R143*	PPP2R2D_uc001lkr.2_Intron|PPP2R2D_uc001lkt.2_Intron|PPP2R2D_uc009yay.2_Nonsense_Mutation_p.R11*	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	176					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		GAGTCCACGGCGAATTTTTGC	0.353													20	39					0	0	0.043863	0	0	
APBB1	322	broad.mit.edu	37	11	6432549	6432549	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:6432549G>A	uc001mdb.1	-	2	129	c.29C>T	c.(28-30)TCG>TTG	p.S10L	APBB1_uc001mdc.1_Missense_Mutation_p.S10L|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	10					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		ATTAATGGCCGACTGGCTCAG	0.617													41	60					0	0	0.111260	0	0	
LOC440040	440040	broad.mit.edu	37	11	49598099	49598099	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:49598099A>C	uc010rhy.1	+	2	690	c.212A>C	c.(211-213)CAT>CCT	p.H71P	LOC440040_uc009ymb.2_Missense_Mutation_p.H71P	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TCCTGCTGGCATTCGGCTGTG	0.532													12	20					0	0	0.093190	0	0	
DAGLA	747	broad.mit.edu	37	11	61488300	61488300	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:61488300G>A	uc001nsa.2	+	3	356	c.245G>A	c.(244-246)CGC>CAC	p.R82H		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	82	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CTGAGCATGCGCGGGGGCATC	0.657													32	77					0	0	0.086207	0	0	
SLC3A2	6520	broad.mit.edu	37	11	62652974	62652974	+	Missense_Mutation	SNP	C	T	T	rs1140538		TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:62652974C>T	uc001nwd.2	+	10	1564	c.1340C>T	c.(1339-1341)GCT>GTT	p.A447V	SLC3A2_uc001nwb.2_Missense_Mutation_p.A478V|SLC3A2_uc001nwc.2_Missense_Mutation_p.A448V|SLC3A2_uc001nwe.2_Missense_Mutation_p.A416V|SLC3A2_uc001nwf.2_Missense_Mutation_p.A385V|SLC3A2_uc001nwg.2_Missense_Mutation_p.A346V	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	447	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						TTCTTGCCGGCTCAACTTCTC	0.577													33	373					0	0	0.173368	0	0	
ARAP1	116985	broad.mit.edu	37	11	72408180	72408180	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:72408180A>C	uc001osu.2	-	22	3203	c.3014T>G	c.(3013-3015)CTG>CGG	p.L1005R	ARAP1_uc001osv.2_Missense_Mutation_p.L1005R|ARAP1_uc001osr.2_Missense_Mutation_p.L765R|ARAP1_uc001oss.2_Missense_Mutation_p.L760R|ARAP1_uc009yth.2_Missense_Mutation_p.L699R|ARAP1_uc010rre.1_Missense_Mutation_p.L760R	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1005	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CAGGCTCTCCAGCAGCCGCTG	0.662													4	40					0	0	0.038147	0	0	
GRM5	2915	broad.mit.edu	37	11	88780628	88780628	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:88780628C>T	uc001pcq.2	-	1	613	c.413G>A	c.(412-414)CGC>CAC	p.R138H	GRM5_uc009yvm.2_Missense_Mutation_p.R138H|GRM5_uc009yvn.1_Missense_Mutation_p.R138H	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	138	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CTTCTTGGAGCGGAAGGAAGA	0.502													16	65					0	0	0.160694	0	0	
FAT3	120114	broad.mit.edu	37	11	92086577	92086577	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:92086577G>A	uc001pdj.3	+	1	1316	c.1299G>A	c.(1297-1299)CGG>CGA	p.R433R		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	433	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTACAGCACGGCCACTGAATA	0.413										TCGA Ovarian(4;0.039)			7	20					0	0	0.029380	0	0	
DYNC2H1	79659	broad.mit.edu	37	11	103022865	103022865	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr11:103022865A>T	uc001pho.2	+	21	3091	c.2947A>T	c.(2947-2949)ATT>TTT	p.I983F	DYNC2H1_uc001phn.1_Missense_Mutation_p.I983F|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	983	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TAACCTTTAGATTTTGCCCTT	0.254													5	25					0	0	0.021553	0	0	
CD4	920	broad.mit.edu	37	12	6923370	6923370	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:6923370C>A	uc001qqv.1	+	4	522	c.277C>A	c.(277-279)CCC>ACC	p.P93T	CD4_uc009zez.1_Missense_Mutation_p.P38T|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_5'UTR|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	93	Extracellular (Potential).|Ig-like V-type.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				AGGAAACTTTCCCCTGATCAT	0.498													58	230					1.54043e-34	1.76216e-34	0.139131	1	0	
FAM90A1	55138	broad.mit.edu	37	12	8375060	8375060	+	Silent	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:8375060G>C	uc001qui.2	-	7	1312	c.753C>G	c.(751-753)CTC>CTG	p.L251L	FAM90A1_uc001quh.2_Silent_p.L251L	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	251							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TGACGGCCTGGAGCAGGCCGT	0.662													9	104					0	0	0.069234	0	0	
A2ML1	144568	broad.mit.edu	37	12	8988261	8988261	+	Silent	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:8988261T>C	uc001quz.3	+	6	740	c.642T>C	c.(640-642)TAT>TAC	p.Y214Y		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	58						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGGAGGAATATGGTAGGTGGG	0.418													23	41					0	0	0.083992	0	0	
KRT72	140807	broad.mit.edu	37	12	52992799	52992799	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:52992799A>G	uc001sar.2	-	2	610	c.524T>C	c.(523-525)ATT>ACT	p.I175T	KRT72_uc001saq.2_Missense_Mutation_p.I175T|KRT72_uc010sns.1_Missense_Mutation_p.I175T|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	175	Linker 1.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		GCCCTCATAAATGGGCTCCAG	0.557													103	144					0	0	0.139131	0	0	
ESPL1	9700	broad.mit.edu	37	12	53668761	53668761	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:53668761C>T	uc001sck.2	+	7	1758	c.1667C>T	c.(1666-1668)GCG>GTG	p.A556V	ESPL1_uc001scj.2_Missense_Mutation_p.A231V	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	556					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AAGATGGATGCGGCCAGGGCT	0.403													3	31					0	0	0.115264	0	0	
HOXC10	3226	broad.mit.edu	37	12	54383121	54383121	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:54383121T>G	uc001sen.2	+	2	1018	c.920T>G	c.(919-921)CTT>CGT	p.L307R	uc001seo.2_5'Flank|MIR196A2_hsa-mir-196a-2|MI0000279_5'Flank	NM_017409	NP_059105	Q9NYD6	HXC10_HUMAN	homeobox C10	307	Homeobox.				positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1						ACCATTAACCTTACAGACAGA	0.418											OREG0021882	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	76					0	0	0.069456	0	0	
SLC16A7	9194	broad.mit.edu	37	12	60173407	60173407	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:60173407G>A	uc001sqs.2	+	6	1683	c.1384G>A	c.(1384-1386)GTC>ATC	p.V462I	SLC16A7_uc001sqt.2_Missense_Mutation_p.V462I|SLC16A7_uc001squ.2_Missense_Mutation_p.V462I|SLC16A7_uc009zqi.2_Missense_Mutation_p.V363I|SLC16A7_uc010ssi.1_Missense_Mutation_p.V363I	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	462	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	AGATGTTAACGTCAAAGTTTC	0.373													10	31					0	0	0.058154	0	0	
MSRB3	253827	broad.mit.edu	37	12	65720710	65720710	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:65720710G>A	uc001ssn.2	+	2	263	c.202G>A	c.(202-204)GAA>AAA	p.E68K	MSRB3_uc001ssm.2_Missense_Mutation_p.E61K|MSRB3_uc009zqp.2_Missense_Mutation_p.E61K	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	68					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GAAAGGGACCGAAAGGTAAGG	0.448													7	24					0	0	0.029380	0	0	
OAS3	4940	broad.mit.edu	37	12	113379501	113379501	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr12:113379501C>T	uc001tug.2	+	2	391	c.304C>T	c.(304-306)CGG>TGG	p.R102W	OAS3_uc001tue.2_Missense_Mutation_p.R102W|OAS3_uc001tuf.2_Missense_Mutation_p.R102W	NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	102	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						CAGTGAGATGCGGGCATCGCT	0.587													5	169					0	0	0.021553	0	0	
SLC46A3	283537	broad.mit.edu	37	13	29287281	29287281	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr13:29287281G>A	uc001usi.2	-	2	1566	c.596C>T	c.(595-597)TCG>TTG	p.S199L	SLC46A3_uc001usg.2_Missense_Mutation_p.S124L|SLC46A3_uc001usj.2_Missense_Mutation_p.S199L|SLC46A3_uc001ush.2_Missense_Mutation_p.S199L|SLC46A3_uc001usk.2_Missense_Mutation_p.S124L	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	199	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		AATTAGAAACGACCACTCAAA	0.353													31	62					0	0	0.153744	0	0	
NAA16	79612	broad.mit.edu	37	13	41947902	41947902	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr13:41947902A>T	uc001uyf.2	+	18	2609	c.2285A>T	c.(2284-2286)CAG>CTG	p.Q762L	NAA16_uc010tfg.1_RNA	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	762					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						ACCTCTCTTCAGCATCTACTT	0.363													50	166					0	0	0.139131	0	0	
ERCC5	2073	broad.mit.edu	37	13	103468859	103468859	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr13:103468859C>G	uc001vpu.1	+	2	682	c.560C>G	c.(559-561)CCT>CGT	p.P187R	BIVM_uc001vps.2_Missense_Mutation_p.P187R|BIVM_uc010agc.2_5'UTR|BIVM_uc001vpt.2_Missense_Mutation_p.P187R	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CAGCATTCTCCTCTTGAAGAT	0.323			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				51	113					0	0	0.139131	0	0	
Unknown	0	broad.mit.edu	37	14	22090682	22090682	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:22090682G>C	uc001wbi.2	+	2	334	c.321G>C	c.(319-321)CAG>CAC	p.Q107H						SubName: Full=Putative uncharacterized protein ENSP00000374929;																		AGGAGCTCCAGATGAAAGACT	0.448													4	100					0	0	0.014758	0	0	
ADCY4	196883	broad.mit.edu	37	14	24788315	24788315	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:24788315C>T	uc001wov.2	-	23	2951	c.2945G>A	c.(2944-2946)CGC>CAC	p.R982H	ADCY4_uc001wow.2_Missense_Mutation_p.R982H|ADCY4_uc010toh.1_Missense_Mutation_p.R668H|ADCY4_uc001wox.2_Missense_Mutation_p.R982H|ADCY4_uc001woy.2_Missense_Mutation_p.R982H	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	982	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		CACTCGCAGGCGGAAGTTGTT	0.567													38	105					0	0	0.104719	0	0	
PRKD1	5587	broad.mit.edu	37	14	30095727	30095727	+	Silent	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:30095727T>C	uc001wqh.2	-	12	1942	c.1761A>G	c.(1759-1761)GAA>GAG	p.E587E		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	587	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AACCCAGTACTTCATCAGGAA	0.318													29	54					0	0	0.163468	0	0	
NRXN3	9369	broad.mit.edu	37	14	80328211	80328211	+	Silent	SNP	C	T	T	rs150091542		TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:80328211C>T	uc001xun.2	+	17	3581	c.3090C>T	c.(3088-3090)TCC>TCT	p.S1030S	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.S606S|NRXN3_uc010asw.2_Silent_p.S428S|NRXN3_uc001xur.3_Silent_p.S401S	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1612	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCAGCAACTCCGCCCAGAGCA	0.527													6	28					0	0	0.047766	0	0	
RIN3	79890	broad.mit.edu	37	14	93125521	93125521	+	Missense_Mutation	SNP	C	T	T	rs138388973		TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:93125521C>T	uc001yap.2	+	7	2194	c.2042C>T	c.(2041-2043)TCT>TTT	p.S681F	RIN3_uc010auk.2_Missense_Mutation_p.S343F|RIN3_uc001yaq.2_Missense_Mutation_p.S606F|RIN3_uc001yar.1_Missense_Mutation_p.S343F|RIN3_uc001yas.1_Missense_Mutation_p.S343F	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	681	Interaction with RAB5B.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				ATTGTAGAGTCTGCCTTGTAC	0.532													11	676					0	0	0.080935	0	0	
AHNAK2	113146	broad.mit.edu	37	14	105410138	105410138	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:105410138C>A	uc010axc.1	-	7	11770	c.11650G>T	c.(11650-11652)GGA>TGA	p.G3884*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.G3784*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3884						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCAGGTGTCCTTTGAGGCCG	0.587													17	225					1.50039e-11	1.66587e-11	0.062417	1	0	
AHNAK2	113146	broad.mit.edu	37	14	105414701	105414701	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr14:105414701T>C	uc010axc.1	-	7	7207	c.7087A>G	c.(7087-7089)ACC>GCC	p.T2363A	AHNAK2_uc001ypx.2_Missense_Mutation_p.T2263A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2363						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGTCAGTGGTCTTGAGGTCC	0.657													4	211					0	0	0.150653	0	0	
C15orf2	23742	broad.mit.edu	37	15	24921084	24921084	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr15:24921084G>A	uc001ywo.2	+	1	544	c.70G>A	c.(70-72)GCC>ACC	p.A24T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	24					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AGGGCGTGGCGCCCCCGCTCC	0.692													6	11					0	0	0.029380	0	0	
WDR72	256764	broad.mit.edu	37	15	53815461	53815461	+	Silent	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr15:53815461C>T	uc002acj.2	-	19	3249	c.3207G>A	c.(3205-3207)GTG>GTA	p.V1069V	WDR72_uc010bfh.1_RNA	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1069										lung(1)|skin(1)	2				all cancers(107;0.0511)		GCATGTCCTCCACGTCTTGGA	0.358													77	184					0	0	0.139131	0	0	
C17orf97	400566	broad.mit.edu	37	17	263712	263712	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:263712G>A	uc002frh.2	+	3	1124	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	C17orf97_uc010vpz.1_RNA	NM_001013672	NP_001013694	Q6ZQX7	CQ097_HUMAN	hypothetical protein LOC400566	390	20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.|19.									ovary(1)	1						CCCCGACCCCGAGGCCCTCAA	0.682													4	47					0	0	0.029380	0	0	
TP53	7157	broad.mit.edu	37	17	7577532	7577532	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:7577532G>A	uc002gim.2	-	7	943	c.749C>T	c.(748-750)CCC>CTC	p.P250L	TP53_uc002gig.1_Missense_Mutation_p.P250L|TP53_uc002gih.2_Missense_Mutation_p.P250L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P118L|TP53_uc010cng.1_Missense_Mutation_p.P118L|TP53_uc002gii.1_Missense_Mutation_p.P118L|TP53_uc010cnh.1_Missense_Mutation_p.P250L|TP53_uc010cni.1_Missense_Mutation_p.P250L|TP53_uc002gij.2_Missense_Mutation_p.P250L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P157L|TP53_uc002gio.2_Missense_Mutation_p.P118L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	250	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> L (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|RP -> SS (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P250L(37)|p.P250S(12)|p.0?(7)|p.P250P(4)|p.P250F(3)|p.P250N(2)|p.P250A(2)|p.M246_P250delMNRRP(2)|p.P250Q(2)|p.P250_L252delPIL(2)|p.P250H(1)|p.P250_I251insXXXXXX(1)|p.N247_P250delNRRP(1)|p.P250T(1)|p.P250_T253delPILT(1)|p.R249_P250insR(1)|p.R249_I251delRPI(1)|p.R248_P250delRRP(1)|p.P250_I251insXXXXXXX(1)|p.R249_T256delRPILTIIT(1)|p.I251fs*94(1)|p.R249_P250>SS(1)|p.R249_P250delRP(1)|p.P250_I251insX(1)|p.P250fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGAGGATGGGCCTCCGGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			46	37					0	0	0.139131	0	0	
HS3ST3A1	9955	broad.mit.edu	37	17	13400097	13400097	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:13400097A>G	uc002gob.1	-	2	1436	c.638T>C	c.(637-639)ATG>ACG	p.M213T		NM_006042	NP_006033	Q9Y663	HS3SA_HUMAN	heparan sulfate D-glucosaminyl	213	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			ovary(1)|central_nervous_system(1)	2		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CGTCTTCTCCATGGTGATCTG	0.607													13	82					0	0	0.119110	0	0	
HS3ST3B1	9953	broad.mit.edu	37	17	14248383	14248383	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:14248383T>C	uc002goh.1	+	2	923	c.593T>C	c.(592-594)ATG>ACG	p.M198T		NM_006041	NP_006032	Q9Y662	HS3SB_HUMAN	heparan sulfate D-glucosaminyl	198	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CAGATCACCATGGAGAAGACG	0.612													8	9					0	0	0.080935	0	0	
ZNF624	57547	broad.mit.edu	37	17	16525840	16525840	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:16525840T>G	uc010cpi.1	-	6	2443	c.2360A>C	c.(2359-2361)AAG>ACG	p.K787T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	787	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AATACAACCCTTTCCACATTC	0.438													4	72					0	0	0.150653	0	0	
RHOT1	55288	broad.mit.edu	37	17	30521045	30521045	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:30521045G>C	uc002hgz.2	+	11	1027	c.788G>C	c.(787-789)AGA>ACA	p.R263T	RHOT1_uc002hgw.2_Missense_Mutation_p.R263T|RHOT1_uc002hgy.2_Missense_Mutation_p.R263T|RHOT1_uc002hha.2_Missense_Mutation_p.R136T|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Missense_Mutation_p.R136T|RHOT1_uc010wby.1_Missense_Mutation_p.R263T|RHOT1_uc002hhb.2_Missense_Mutation_p.R242T|RHOT1_uc002hgv.2_Missense_Mutation_p.R263T	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	263	Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				CAGAGAGGGAGACACGAAACT	0.363													11	473					0	0	0.069234	0	0	
C17orf102	400591	broad.mit.edu	37	17	32906083	32906083	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:32906083T>C	uc002hie.1	-	1	306	c.217A>G	c.(217-219)ACC>GCC	p.T73A	TMEM132E_uc002hif.2_5'Flank	NM_207454	NP_997337	A2RUQ5	CQ102_HUMAN	hypothetical protein LOC400591	73										ovary(1)	1						GGGGTGGGGGTAGGGTGCCCC	0.682													8	61					0	0	0.069234	0	0	
AARSD1	80755	broad.mit.edu	37	17	41102638	41102638	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:41102638T>C	uc002icc.2	-	12	1214	c.1211A>G	c.(1210-1212)TAC>TGC	p.Y404C	AARSD1_uc002icd.2_Missense_Mutation_p.Y517C|AARSD1_uc002ice.2_Missense_Mutation_p.Y487C|AARSD1_uc002icf.2_Missense_Mutation_p.Y578C|AARSD1_uc010whg.1_Missense_Mutation_p.Y578C	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	404					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGTGCTGATGTAGTCCTGGAG	0.537													24	23					0	0	0.083992	0	0	
BRCA1	672	broad.mit.edu	37	17	41245963	41245963	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:41245963G>A	uc002icq.2	-	10	1817	c.1585C>T	c.(1585-1587)CCT>TCT	p.P529S	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.P458S|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.P482S|BRCA1_uc002ict.2_Missense_Mutation_p.P529S|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.P529S|BRCA1_uc002ide.1_Missense_Mutation_p.P360S|BRCA1_uc010cyy.1_Missense_Mutation_p.P529S|BRCA1_uc010whs.1_Missense_Mutation_p.P529S|BRCA1_uc010cyz.2_Missense_Mutation_p.P482S|BRCA1_uc010cza.2_Missense_Mutation_p.P503S|BRCA1_uc010wht.1_Missense_Mutation_p.P233S	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	529					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ATCATTTCAGGAGTCTTTTGA	0.378			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			22	27					0	0	0.062417	0	0	
USP32	84669	broad.mit.edu	37	17	58299833	58299833	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:58299833G>A	uc002iyo.1	-	15	1972	c.1686C>T	c.(1684-1686)GTC>GTT	p.V562V	USP32_uc002iyn.1_Silent_p.V232V	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	562	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CAGGTTCTGGGACCATTTCAT	0.413													115	371					0	0	0.139131	0	0	
C17orf77	146723	broad.mit.edu	37	17	72588276	72588276	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr17:72588276T>C	uc002jla.1	+	3	453	c.91T>C	c.(91-93)TGC>CGC	p.C31R	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	31						extracellular region					0						GTCATTCCAGTGCCTTAAAGC	0.547													15	41					0	0	0.099896	0	0	
OSBPL1A	114876	broad.mit.edu	37	18	21894248	21894248	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr18:21894248G>A	uc002kve.2	-	12	1108	c.934C>T	c.(934-936)CGG>TGG	p.R312W	OSBPL1A_uc010xbc.1_5'Flank|OSBPL1A_uc002kvf.3_Missense_Mutation_p.R92W	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	312	PH.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TTAGGAACCCGGAAGCCATGA	0.363													36	173					0	0	0.080422	0	0	
ZBTB7C	201501	broad.mit.edu	37	18	45566902	45566902	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr18:45566902C>G	uc002lda.2	-	1	593	c.577G>C	c.(577-579)GAC>CAC	p.D193H	ZBTB7C_uc002ldb.2_Missense_Mutation_p.D193H|ZBTB7C_uc010dnu.2_Missense_Mutation_p.D202H|ZBTB7C_uc010dnv.2_Missense_Mutation_p.D215H|ZBTB7C_uc010dnw.2_Missense_Mutation_p.D193H|ZBTB7C_uc010dnx.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dny.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dnz.1_Missense_Mutation_p.D215H|ZBTB7C_uc010dob.1_Missense_Mutation_p.D193H|ZBTB7C_uc010doc.1_Missense_Mutation_p.D202H|ZBTB7C_uc010dod.1_Missense_Mutation_p.D215H|ZBTB7C_uc010doe.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dof.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dog.1_Missense_Mutation_p.D193H|ZBTB7C_uc010doh.1_Missense_Mutation_p.D202H|ZBTB7C_uc010doi.1_Missense_Mutation_p.D193H|ZBTB7C_uc010doj.1_Missense_Mutation_p.D202H|ZBTB7C_uc010dok.1_Missense_Mutation_p.D242H|ZBTB7C_uc010dol.1_Missense_Mutation_p.D202H|ZBTB7C_uc010doa.1_Missense_Mutation_p.D215H|ZBTB7C_uc010don.1_Missense_Mutation_p.D201H|ZBTB7C_uc010doo.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dop.1_Missense_Mutation_p.D193H|ZBTB7C_uc010doq.1_Missense_Mutation_p.D202H|ZBTB7C_uc010dor.1_Missense_Mutation_p.D215H|ZBTB7C_uc010dos.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dot.1_Missense_Mutation_p.D193H|ZBTB7C_uc010dou.1_Missense_Mutation_p.D202H|ZBTB7C_uc010dom.1_Missense_Mutation_p.D202H	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	193						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GTGAGATGGTCTGTCTTGGAA	0.537													3	139					0	0	0.150653	0	0	
ATP8B1	5205	broad.mit.edu	37	18	55362738	55362738	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr18:55362738G>C	uc002lgw.2	-	8	725	c.725C>G	c.(724-726)TCA>TGA	p.S242*	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	242	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GATTTCAAGTGACATCTTAAA	0.308									Byler_disease				4	69					0	0	0.014758	0	0	
ZNF532	55205	broad.mit.edu	37	18	56646352	56646352	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr18:56646352G>A	uc002lho.2	+	9	3763	c.3216G>A	c.(3214-3216)CGG>CGA	p.R1072R	ZNF532_uc002lhp.2_Silent_p.R1070R|ZNF532_uc010xeg.1_Silent_p.R1070R|ZNF532_uc002lhr.2_Silent_p.R1070R|ZNF532_uc002lhs.2_Silent_p.R1070R|ZNF532_uc010xeh.1_Silent_p.R164R	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1072	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCCTGTGCCGGCACAACCGGA	0.532													4	184					0	0	0.014758	0	0	
WDR18	57418	broad.mit.edu	37	19	992110	992110	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:992110C>T	uc002lqm.1	+	8	1113	c.1087C>T	c.(1087-1089)CTC>TTC	p.L363F	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Missense_Mutation_p.L326F|WDR18_uc010dry.1_Missense_Mutation_p.L363F	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	363										skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCCTGGGCCTCCACCAGCA	0.726													3	2					0	0	0.150653	0	0	
RDH8	50700	broad.mit.edu	37	19	10129585	10129585	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:10129585G>A	uc002mmr.2	+	3	690	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	147	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TGGGCCTGCAGGGTGAGCTGT	0.552													27	33					0	0	0.153744	0	0	
DNMT1	1786	broad.mit.edu	37	19	10273405	10273405	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:10273405C>T	uc002mng.2	-	12	1078	c.898G>A	c.(898-900)GAA>AAA	p.E300K	DNMT1_uc010xlc.1_Missense_Mutation_p.E316K|DNMT1_uc002mnh.2_Missense_Mutation_p.E195K|DNMT1_uc010xld.1_Missense_Mutation_p.E300K|DNMT1_uc002mnk.2_RNA	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	300	Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCTTTTTCTTCGGGCCTCCGT	0.408													5	123					0	0	0.021553	0	0	
CACNA1A	773	broad.mit.edu	37	19	13411396	13411396	+	Silent	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:13411396A>G	uc010dze.2	-	18	2486	c.2250T>C	c.(2248-2250)AGT>AGC	p.S750S	CACNA1A_uc010dzc.2_Silent_p.S275S|CACNA1A_uc002mwy.3_Silent_p.S749S|CACNA1A_uc010xne.1_Silent_p.S278S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	750	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGGACAGAGGACTCACTTCTG	0.527													63	302					0	0	0.139131	0	0	
WIZ	58525	broad.mit.edu	37	19	15559049	15559049	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:15559049G>A	uc002nbb.3	-	2	284	c.70C>T	c.(70-72)CCG>TCG	p.P24S	MIR1470_hsa-mir-1470|MI0007075_5'Flank	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1105	Pro-rich.					nucleus	zinc ion binding				0						CTTGGCGCCGGGCCAGGCAGT	0.647													10	177					0	0	0.080935	0	0	
ZNF738	148203	broad.mit.edu	37	19	21558722	21558722	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:21558722A>T	uc002nps.3	+	4	483	c.275A>T	c.(274-276)GAT>GTT	p.D92V	ZNF738_uc002npt.3_RNA	NR_027130				SubName: Full=cDNA FLJ14673 fis, clone NT2RP2003714, moderately similar to Zinc finger protein 430;												0						CAAGGAAAAGATCCCTGGAAT	0.373													23	359					0	0	0.069288	0	0	
ZNF599	148103	broad.mit.edu	37	19	35250430	35250430	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr19:35250430T>A	uc010edn.1	-	4	1664	c.1276A>T	c.(1276-1278)AAA>TAA	p.K426*	ZNF599_uc010edm.1_Nonsense_Mutation_p.K389*	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	426	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CCACATTCTTTGCACTCAAAG	0.473													21	309					0	0	0.062417	0	0	
IAH1	285148	broad.mit.edu	37	2	9624561	9624561	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:9624561G>T	uc002qzr.2	+	5	472	c.446G>T	c.(445-447)GGT>GTT	p.G149V	IAH1_uc002qzs.2_Missense_Mutation_p.G36V|IAH1_uc002qzt.2_Missense_Mutation_p.G36V|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	149					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TCTTCAATAGGTTGCAAACTA	0.458													4	103					0.00024832	0.000269758	0.150653	1	0	
TET3	200424	broad.mit.edu	37	2	74328640	74328640	+	Silent	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:74328640G>C	uc002skb.3	+	9	4320	c.4320G>C	c.(4318-4320)CTG>CTC	p.L1440L		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1440							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CCAGCCAGCTGGACAGGGCCT	0.612													4	18					0	0	0.038147	0	0	
GGT8P	645367	broad.mit.edu	37	2	91968599	91968599	+	RNA	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:91968599G>C	uc010fho.1	+	2		c.930G>C				NR_003503				Homo sapiens cDNA FLJ31276 fis, clone KIDNE2006376, weakly similar to GAMMA-GLUTAMYLTRANSPEPTIDASE 1 PRECURSOR (EC 2.3.2.2).												0						AAAACAAGCGGACCGTCATCG	0.672													4	67					0	0	0.014758	0	0	
RGPD5	84220	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:113127775G>C	uc002ths.1	-	23	5355	c.5278C>G	c.(5278-5280)CCT>GCT	p.P1760A	RGPD8_uc010fkk.1_Missense_Mutation_p.P1620A	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	1760					intracellular transport	cytoplasm	binding				0						GAACGGGAAGGATTTTCTTCC	0.308													3	90					0	0	0.115264	0	0	
XIRP2	129446	broad.mit.edu	37	2	168104460	168104460	+	Silent	SNP	T	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:168104460T>G	uc002udx.2	+	8	6576	c.6558T>G	c.(6556-6558)ACT>ACG	p.T2186T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T2011T|XIRP2_uc010fpq.2_Silent_p.T1964T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2011					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAAGCAAACTTTGTTAAAGC	0.408													25	75					0	0	0.091800	0	0	
XIRP2	129446	broad.mit.edu	37	2	168107180	168107180	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:168107180G>A	uc002udx.2	+	8	9296	c.9278G>A	c.(9277-9279)CGT>CAT	p.R3093H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2918H|XIRP2_uc010fpq.2_Missense_Mutation_p.R2871H|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2918					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCAACTGTTCGTAGTCACGTG	0.378													37	93					0	0	0.074837	0	0	
PGAP1	80055	broad.mit.edu	37	2	197708744	197708744	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:197708744G>C	uc002utw.2	-	25	2507	c.2393C>G	c.(2392-2394)TCA>TGA	p.S798*	PGAP1_uc002utx.2_Nonsense_Mutation_p.S624*|PGAP1_uc010fsi.2_Nonsense_Mutation_p.S72*	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	798	Cytoplasmic (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						ATGGTGTATTGAGGAGTCTTT	0.348													20	48					0	0	0.049695	0	0	
NBEAL1	65065	broad.mit.edu	37	2	204000806	204000806	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:204000806T>A	uc002uzt.3	+	27	4466	c.4133T>A	c.(4132-4134)ATT>AAT	p.I1378N	NBEAL1_uc002uzs.3_Missense_Mutation_p.I88N	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1378							binding			ovary(1)|skin(1)	2						CTCAGTGGAATTGACTCATGT	0.433													23	74					0	0	0.076483	0	0	
NEU4	129807	broad.mit.edu	37	2	242758315	242758315	+	Missense_Mutation	SNP	G	A	A	rs144038379	by1000genomes	TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr2:242758315G>A	uc010fzr.2	+	4	1482	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.A466T|NEU4_uc002wcn.1_Missense_Mutation_p.A478T|NEU4_uc002wco.1_Missense_Mutation_p.A466T|NEU4_uc002wcp.1_Missense_Mutation_p.A478T	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	466						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GAACGTGCCCGCCAGCCCCAA	0.642													6	9					0	0	0.029380	0	0	
HSPA12B	116835	broad.mit.edu	37	20	3726571	3726571	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr20:3726571G>A	uc002wjd.2	+	7	671	c.568G>A	c.(568-570)GAG>AAG	p.E190K	HSPA12B_uc010zqi.1_Missense_Mutation_p.E189K|HSPA12B_uc002wje.2_Missense_Mutation_p.E103K|HSPA12B_uc010zqj.1_Missense_Mutation_p.E24K	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	190							ATP binding				0						GGAGCTGAGGGAGCAGAGCCC	0.602													38	87					0	0	0.104719	0	0	
FAM182B	728882	broad.mit.edu	37	20	25848617	25848617	+	RNA	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr20:25848617A>G	uc002wvd.1	-	1		c.170T>C								Homo sapiens cDNA FLJ30282 fis, clone BRACE2002803.												0						ggcaggcctgaggctgggatg	0													3	5					0	0	0.150653	0	0	
BCL2L13	23786	broad.mit.edu	37	22	18209612	18209612	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr22:18209612C>T	uc002zmw.2	+	7	988	c.770C>T	c.(769-771)TCA>TTA	p.S257L	BCL2L13_uc002zmx.2_Missense_Mutation_p.S95L|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.S95L|BCL2L13_uc011agk.1_Missense_Mutation_p.S133L|BCL2L13_uc010gqz.2_5'UTR|BCL2L13_uc002zmz.2_Missense_Mutation_p.S95L|BCL2L13_uc002zna.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	257					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		GTGTCACTGTCAGCTAGCCAG	0.527													16	39					0	0	0.049695	0	0	
BCL2L13	23786	broad.mit.edu	37	22	18209747	18209747	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr22:18209747C>G	uc002zmw.2	+	7	1123	c.905C>G	c.(904-906)TCC>TGC	p.S302C	BCL2L13_uc002zmx.2_Missense_Mutation_p.S140C|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.S140C|BCL2L13_uc011agk.1_Missense_Mutation_p.S178C|BCL2L13_uc010gqz.2_Missense_Mutation_p.S22C|BCL2L13_uc002zmz.2_Missense_Mutation_p.S140C|BCL2L13_uc002zna.2_Missense_Mutation_p.S22C	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	302					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		GAGAACAACTCCTCTAATTCT	0.537													7	66					0	0	0.038147	0	0	
SGSM1	129049	broad.mit.edu	37	22	25313668	25313668	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr22:25313668A>G	uc003abg.2	+	24	3294	c.3137A>G	c.(3136-3138)GAC>GGC	p.D1046G	SGSM1_uc003abh.2_Missense_Mutation_p.D985G|SGSM1_uc010guu.1_Missense_Mutation_p.D991G|SGSM1_uc003abj.2_Missense_Mutation_p.D930G|SGSM1_uc003abi.1_Missense_Mutation_p.D966G	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	1046	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						CAGAACGGGGACTATACTCAC	0.502													4	55					0	0	0.150653	0	0	
ZNRF3	84133	broad.mit.edu	37	22	29445281	29445281	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr22:29445281G>A	uc003aeg.2	+	8	977	c.812G>A	c.(811-813)CGC>CAC	p.R271H	ZNRF3_uc003aeh.1_Missense_Mutation_p.R271H	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	371	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						TACCCCGGCCGCGTGCACAGG	0.642													29	76					0	0	0.069456	0	0	
EPM2AIP1	9852	broad.mit.edu	37	3	37033459	37033459	+	Silent	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:37033459G>C	uc003cgk.2	-	1	1337	c.1110C>G	c.(1108-1110)GTC>GTG	p.V370V	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	370						endoplasmic reticulum					0						CTGAGAAGTGGACTGTTGTTG	0.398													4	438					0	0	0.150653	0	0	
CNTN3	5067	broad.mit.edu	37	3	74351856	74351856	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:74351856C>G	uc003dpm.1	-	13	1851	c.1771G>C	c.(1771-1773)GAC>CAC	p.D591H		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	591	Ig-like C2-type 6.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACTATGAGGTCAGCAGCAGAT	0.403													10	33					0	0	0.093190	0	0	
OR5H14	403273	broad.mit.edu	37	3	97869090	97869090	+	Silent	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:97869090C>G	uc003dsg.1	+	1	861	c.861C>G	c.(859-861)CCC>CCG	p.P287P		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TATTAAATCCCATGATCTACA	0.363													20	47					0	0	0.083992	0	0	
ZBED2	79413	broad.mit.edu	37	3	111312961	111312961	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:111312961C>G	uc003dxy.2	-	2	973	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	30							DNA binding|metal ion binding			skin(1)	1						TCTCCTGTCTCACTAATCTCT	0.512													7	113					0	0	0.029380	0	0	
PHLDB2	90102	broad.mit.edu	37	3	111659435	111659435	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:111659435G>A	uc010hqa.2	+	8	2751	c.2340G>A	c.(2338-2340)CAG>CAA	p.Q780Q	PHLDB2_uc003dyc.2_Silent_p.Q764Q|PHLDB2_uc003dyd.2_Silent_p.Q737Q|PHLDB2_uc003dyg.2_Silent_p.Q780Q|PHLDB2_uc003dyh.2_Silent_p.Q737Q|PHLDB2_uc003dyi.2_Silent_p.Q366Q	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	780	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AGCAGGCTCAGAGAGAGCAAG	0.348													13	40					0	0	0.093190	0	0	
WDR52	55779	broad.mit.edu	37	3	113120574	113120574	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:113120574C>T	uc003eae.1	-	10	1229	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	395	WD 4.									central_nervous_system(1)	1						TCTATTGTCTCAAAATCCCAT	0.313													18	78					0	0	0.069288	0	0	
GOLGB1	2804	broad.mit.edu	37	3	121445864	121445864	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr3:121445864C>T	uc003eei.3	-	5	553	c.427G>A	c.(427-429)GAG>AAG	p.E143K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E143K|GOLGB1_uc003eej.3_Missense_Mutation_p.E104K|GOLGB1_uc011bjm.1_Missense_Mutation_p.E104K|GOLGB1_uc010hrd.1_Missense_Mutation_p.E143K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	143	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ATTTCCATCTCTTCCTCTGTA	0.348													20	51					0	0	0.062417	0	0	
NDST3	9348	broad.mit.edu	37	4	119059215	119059215	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr4:119059215G>A	uc003ibx.2	+	5	1634	c.1231G>A	c.(1231-1233)GGC>AGC	p.G411S	NDST3_uc011cgf.1_Missense_Mutation_p.G330S	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	411	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TTAGGAGCACGGCATTCCAAC	0.418													28	40					0	0	0.144211	0	0	
SCAND3	114821	broad.mit.edu	37	6	28543037	28543037	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:28543037C>G	uc003nlo.2	-	3	2063	c.1445G>C	c.(1444-1446)AGG>ACG	p.R482T		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	482	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAGAAAATCCTCTTTCGGAT	0.423													29	96					0	0	0.125774	0	0	
RGL2	5863	broad.mit.edu	37	6	33263368	33263368	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:33263368C>A	uc003odv.2	-	7	1070	c.937G>T	c.(937-939)GAG>TAG	p.E313*	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Nonsense_Mutation_p.E231*|RGL2_uc011drb.1_Nonsense_Mutation_p.E231*	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	313	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CCAGGTCCCTCTCCAGTGGAA	0.597													7	49					4.68919e-08	5.16838e-08	0.069234	1	0	
ITPR3	3710	broad.mit.edu	37	6	33652629	33652629	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:33652629A>G	uc011drk.1	+	39	5435	c.5216A>G	c.(5215-5217)GAC>GGC	p.D1739G	ITPR3_uc003oey.2_5'Flank	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1739	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TTGGTATGCGACCTCATCACC	0.627													12	152					0	0	0.119110	0	0	
EYS	346007	broad.mit.edu	37	6	66063378	66063378	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:66063378C>T	uc011dxu.1	-	9	1970	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	EYS_uc003peq.2_Missense_Mutation_p.E478K|EYS_uc003per.1_Missense_Mutation_p.E478K	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	478					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CACACATATTCAAATTGAGCA	0.343													35	82					0	0	0.092188	0	0	
KHDC1	80759	broad.mit.edu	37	6	73952192	73952192	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:73952192G>A	uc003pgo.2	-	3	769	c.268C>T	c.(268-270)CCT>TCT	p.P90S	KHDC1_uc011dyl.1_RNA|KHDC1_uc003pgn.3_Missense_Mutation_p.P17S	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	90						integral to membrane	RNA binding			skin(1)	1						AAGTTTTGAGGCAGGGTCCAC	0.542													29	79					0	0	0.144211	0	0	
MRAP2	112609	broad.mit.edu	37	6	84798909	84798909	+	Silent	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:84798909C>T	uc003pkg.3	+	4	517	c.327C>T	c.(325-327)AAC>AAT	p.N109N	MRAP2_uc010kbo.2_Silent_p.N23N	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	109					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						GCCAAGGCAACGAGGAGTCCA	0.498													49	100					0	0	0.139131	0	0	
GRIK2	2898	broad.mit.edu	37	6	102247533	102247533	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:102247533C>T	uc003pqp.3	+	7	1211	c.962C>T	c.(961-963)GCT>GTT	p.A321V	GRIK2_uc003pqn.2_Missense_Mutation_p.A321V|GRIK2_uc003pqo.3_Missense_Mutation_p.A321V|GRIK2_uc010kcw.2_Missense_Mutation_p.A321V	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	321	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ACTGATGCTGCTCTAATGTAT	0.448													57	166					0	0	0.139131	0	0	
PERP	64065	broad.mit.edu	37	6	138428360	138428360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr6:138428360C>T	uc003qht.2	-	1	301	c.118G>A	c.(118-120)GAC>AAC	p.D40N		NM_022121	NP_071404	Q96FX8	PERP_HUMAN	PERP, TP53 apoptosis effector	40					apoptosis|cell adhesion	desmosome|Golgi apparatus|integral to membrane|nucleus					0	Breast(32;0.0799)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000878)|OV - Ovarian serous cystadenocarcinoma(155;0.000997)		TGGCCGTGGTCGCTAGACTGC	0.677													12	88					0	0	0.132662	0	0	
C7orf70	84792	broad.mit.edu	37	7	6370486	6370486	+	Silent	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr7:6370486C>T	uc003spu.2	-	2	768	c.300G>A	c.(298-300)CCG>CCA	p.P100P		NM_001037163	NP_001032240	Q7Z4H9	SIPAR_HUMAN	hypothetical protein LOC84792	100						nucleus					0						CGGCTGTGCTCGGAGTGGCTG	0.597													17	73					0	0	0.055883	0	0	
OGDH	4967	broad.mit.edu	37	7	44687316	44687316	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr7:44687316T>C	uc003tln.2	+	4	584	c.475T>C	c.(475-477)TCC>CCC	p.S159P	OGDH_uc003tlm.2_Missense_Mutation_p.S159P|OGDH_uc011kbx.1_Intron|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Intron|OGDH_uc011kbz.1_Silent_p.T5T|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	159					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TGATCTGGACTCCTCCGTGCC	0.557													3	118					0	0	0.115264	0	0	
SPDYE5	442590	broad.mit.edu	37	7	75130923	75130923	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr7:75130923A>G	uc011kfy.1	+	6	934	c.798A>G	c.(796-798)ATA>ATG	p.I266M		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	266	Arg-rich.										0						GCTCTCGCATACCCTTGCTCC	0.587													65	215					0	0	0.139131	0	0	
PTPRZ1	5803	broad.mit.edu	37	7	121653684	121653684	+	Silent	SNP	T	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr7:121653684T>C	uc003vjy.2	+	12	4979	c.4584T>C	c.(4582-4584)AGT>AGC	p.S1528S	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1528	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AGACTGGTAGTGCTCTGCTTC	0.448													10	49					0	0	0.069234	0	0	
ERICH1	157697	broad.mit.edu	37	8	642594	642594	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:642594G>A	uc003wph.2	-	3	253	c.188C>T	c.(187-189)CCG>CTG	p.P63L	ERICH1_uc011kwh.1_Missense_Mutation_p.P63L|ERICH1_uc003wpe.1_Intron	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	63										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		TCGGGCAGTCGGGGTCTCAGA	0.567													16	31					0	0	0.146539	0	0	
ZFHX4	79776	broad.mit.edu	37	8	77767078	77767078	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:77767078G>A	uc003yav.2	+	10	8173	c.7786G>A	c.(7786-7788)GAA>AAA	p.E2596K	ZFHX4_uc003yau.1_Missense_Mutation_p.E2641K|ZFHX4_uc003yaw.1_Missense_Mutation_p.E2596K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2596	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TATTGCCCGCGAAGTCGGGCT	0.512										HNSCC(33;0.089)			23	54					0	0	0.069288	0	0	
ZFAT	57623	broad.mit.edu	37	8	135614852	135614852	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:135614852G>C	uc003yup.2	-	6	1285	c.1110C>G	c.(1108-1110)ATC>ATG	p.I370M	ZFAT_uc003yun.2_Missense_Mutation_p.I358M|ZFAT_uc003yuo.2_Missense_Mutation_p.I358M|ZFAT_uc010meh.2_Missense_Mutation_p.I358M|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.I358M|ZFAT_uc010mej.2_Missense_Mutation_p.I308M|ZFAT_uc003yur.2_Missense_Mutation_p.I358M	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	370	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGATGTGCTTGATGAGGTTCT	0.567													10	126					0	0	0.058154	0	0	
TRAPPC9	83696	broad.mit.edu	37	8	141415757	141415757	+	Silent	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:141415757A>G	uc003yvj.2	-	6	1061	c.927T>C	c.(925-927)ACT>ACC	p.T309T	TRAPPC9_uc003yvh.2_Silent_p.T407T|TRAPPC9_uc003yvi.1_Silent_p.T300T	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	309					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						GTCCGATCTCAGTACTGGTGT	0.408													3	71					0	0	0.115264	0	0	
SLC45A4	57210	broad.mit.edu	37	8	142229090	142229090	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:142229090C>G	uc003ywd.1	-	4	804	c.496G>C	c.(496-498)GAC>CAC	p.D166H	SLC45A4_uc003ywc.1_Missense_Mutation_p.D166H|SLC45A4_uc010meq.1_Missense_Mutation_p.D164H	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	217					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGGGTCCAGTCCAGCCCACCC	0.667													26	78					0	0	0.134883	0	0	
CPSF1	29894	broad.mit.edu	37	8	145621891	145621891	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr8:145621891G>A	uc003zcj.2	-	25	2823	c.2748C>T	c.(2746-2748)GGC>GGT	p.G916G		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	916					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCTCTGCGCCGCCACCTTCTG	0.627													68	144					0	0	0.139131	0	0	
FLJ46321	389763	broad.mit.edu	37	9	84607898	84607898	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr9:84607898T>G	uc004amn.2	+	4	2560	c.2513T>G	c.(2512-2514)TTT>TGT	p.F838C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	838						integral to membrane					0						AGCAAGAAATTTGAGGAAATC	0.448													31	76					0	0	0.064281	0	0	
FAM120A	23196	broad.mit.edu	37	9	96214522	96214522	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr9:96214522G>A	uc004atw.2	+	1	350	c.325G>A	c.(325-327)GTC>ATC	p.V109I	FAM120AOS_uc004atm.2_5'Flank|FAM120AOS_uc004atn.3_5'Flank|FAM120AOS_uc004ato.3_5'Flank|FAM120AOS_uc004atp.3_5'Flank|FAM120AOS_uc004atq.3_5'Flank|FAM120AOS_uc004atr.3_5'Flank|FAM120AOS_uc004ats.3_Intron|FAM120AOS_uc004att.3_Intron|FAM120AOS_uc004atu.3_Missense_Mutation_p.T157I|FAM120A_uc004atv.2_Missense_Mutation_p.V109I	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	109						cytoplasm|plasma membrane	RNA binding				0						GCACGAGTGGGTCAAGCGGCA	0.667													5	4					0	0	0.069234	0	0	
RGS3	5998	broad.mit.edu	37	9	116346512	116346512	+	Silent	SNP	G	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr9:116346512G>A	uc004bhq.2	+	21	3029	c.2820G>A	c.(2818-2820)CGG>CGA	p.R940R	RGS3_uc004bhs.2_Silent_p.R830R|RGS3_uc004bht.2_Silent_p.R659R|RGS3_uc010muy.2_Intron|RGS3_uc004bhv.2_Silent_p.R261R|RGS3_uc010muz.1_Silent_p.R279R|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Silent_p.R250R|RGS3_uc004bhx.2_Silent_p.R261R|RGS3_uc004bhy.1_Silent_p.R250R|RGS3_uc004bhz.2_Silent_p.R282R	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	940					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						TGCGGCGCCGGACGCACAGCG	0.697													31	72					0	0	0.153744	0	0	
DFNB31	25861	broad.mit.edu	37	9	117185721	117185721	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr9:117185721A>G	uc004biz.3	-	7	2148	c.1499T>C	c.(1498-1500)ATT>ACT	p.I500T	DFNB31_uc004bix.2_Missense_Mutation_p.I149T|DFNB31_uc004biy.3_Missense_Mutation_p.I117T|DFNB31_uc004bja.3_Missense_Mutation_p.I500T	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	500					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CATGGACTCAATCTCACGCCT	0.622													24	118					0	0	0.183431	0	0	
HUWE1	10075	broad.mit.edu	37	X	53564520	53564520	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chrX:53564520C>T	uc004dsp.2	-	78	12536	c.12134G>A	c.(12133-12135)CGA>CAA	p.R4045Q	HUWE1_uc004dsn.2_Missense_Mutation_p.R2853Q|HUWE1_uc004dsq.1_Missense_Mutation_p.R345Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4045	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CCCTTACAATCGATTCTTCAT	0.537													8	4					0	0	0.058154	0	0	
NRK	203447	broad.mit.edu	37	X	105197150	105197150	+	Silent	SNP	C	T	T			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chrX:105197150C>T	uc004emd.2	+	28	4941	c.4638C>T	c.(4636-4638)TGC>TGT	p.C1546C	NRK_uc011msi.1_Silent_p.C127C	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1546	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GATTCCTGTGCACCCGGGGTG	0.463										HNSCC(51;0.14)			4	7					0	0	0.150653	0	0	
MTX1	4580	broad.mit.edu	37	1	155179076	155179076	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr1:155179076delG	uc001fjb.2	+	1	587	c.481delG	c.(481-483)GGGfs	p.G161fs	RAG1AP1_uc010pey.1_Intron|THBS3_uc001fix.2_5'Flank|THBS3_uc009wqi.2_5'Flank|THBS3_uc001fiz.2_5'Flank|THBS3_uc001fiy.2_5'Flank|THBS3_uc010pfu.1_5'Flank|THBS3_uc010pfv.1_5'Flank|THBS3_uc001fja.2_5'Flank|THBS3_uc009wqj.1_5'Flank|MTX1_uc001fjc.2_Frame_Shift_Del_p.G161fs	NM_002455	NP_002446	Q13505	MTX1_HUMAN	metaxin 1 isoform 1	161					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			skin(1)	1	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGCTGGTCAGGGGGCTGGGG	0.706													2	4	---	---	---	---						.
TPPP3	51673	broad.mit.edu	37	16	67424253	67424254	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr16:67424253_67424254delCT	uc002esz.2	-	3	1189_1190	c.354_355delAG	c.(352-357)ACAGGGfs	p.T118fs	TPPP3_uc002eta.2_Frame_Shift_Del_p.T118fs|TPPP3_uc002etb.2_Frame_Shift_Del_p.T118fs	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	118_119					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		ACAGCACCCCCTGTTTTTGCTT	0.619													47	107	---	---	---	---						.
ATP10B	23120	broad.mit.edu	37	5	160067471	160067472	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4449-01A-01D-1158-08	TCGA-CG-4449-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	fa76e231-afc1-490d-8463-4438ee64a36f	1318498f-4165-4777-b997-e3ec9346d8ef	g.chr5:160067471_160067472insA	uc003lym.1	-	10	1843_1844	c.996_997insT	c.(994-999)GCTGTAfs	p.A332fs	ATP10B_uc003lyp.2_Frame_Shift_Ins_p.A332fs|ATP10B_uc011deg.1_Frame_Shift_Ins_p.A376fs|ATP10B_uc003lyo.2_Frame_Shift_Ins_p.A304fs	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	332_333	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCATACCTACAGCTCCAATAA	0.371													46	80	---	---	---	---						.
