Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
KLHL21	9903	broad.mit.edu	37	1	6653646	6653646	+	Nonsense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:6653646C>A	uc001aoa.2	-	4	1625	c.1573G>T	c.(1573-1575)GAA>TAA	p.E525*	KLHL21_uc001anz.1_3'UTR|KLHL21_uc009vme.2_Nonsense_Mutation_p.E158*	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	525	Kelch 6.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		TCCGAGAGTTCAAATGTATTG	0.607													5	25					0.000602214	0.000638492	0.000602	1	0	
MST1P2	11209	broad.mit.edu	37	1	16974312	16974312	+	RNA	SNP	G	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:16974312G>C	uc009vow.2	+	5		c.1122G>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_RNA|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GAGGCCACAAGTGTCAGCTGC	0.657													7	45					0	0	0.004482	0	0	
AKR7A3	22977	broad.mit.edu	37	1	19612421	19612421	+	Silent	SNP	G	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:19612421G>C	uc001bbv.1	-	3	545	c.468C>G	c.(466-468)CTC>CTG	p.L156L		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	156					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTCTTGCAGAGGGTACAGA	0.587													11	35					0	0	0.010729	0	0	
DLGAP3	58512	broad.mit.edu	37	1	35370318	35370318	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:35370318G>T	uc001byc.2	-	1	667	c.667C>A	c.(667-669)CAT>AAT	p.H223N		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	223	Poly-His.				cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				tggtggtgatggGAGGTGTGG	0.552													12	47					9.05144e-12	1.07639e-11	0.001855	1	0	
TIE1	7075	broad.mit.edu	37	1	43778104	43778104	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:43778104G>A	uc001ciu.2	+	12	1838	c.1759G>A	c.(1759-1761)GGG>AGG	p.G587R	TIE1_uc010okd.1_Missense_Mutation_p.G587R|TIE1_uc010oke.1_Missense_Mutation_p.G542R|TIE1_uc009vwq.2_Missense_Mutation_p.G543R|TIE1_uc010okf.1_Missense_Mutation_p.G232R|TIE1_uc010okg.1_Missense_Mutation_p.G232R	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	587	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTGTGGGACGGGACACGGGG	0.692													9	25					0	0	0.008291	0	0	
CYP4Z2P	163720	broad.mit.edu	37	1	47351203	47351203	+	RNA	SNP	A	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:47351203A>T	uc001cqo.1	-	4		c.458T>A			CYP4Z2P_uc009vyn.1_RNA	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						CAGGTTTCACAATCTGGCGGT	0.448													8	27					0	0	0.003080	0	0	
ORC1L	4998	broad.mit.edu	37	1	52861837	52861837	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:52861837G>A	uc001ctt.2	-	5	821	c.602C>T	c.(601-603)TCT>TTT	p.S201F	ORC1L_uc010oni.1_Missense_Mutation_p.S201F|ORC1L_uc001ctu.2_Missense_Mutation_p.S201F|ORC1L_uc009vzd.2_5'UTR	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	201					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TGGGGTCCAAGAAGGGCTCTC	0.512													19	53					0	0	0.007413	0	0	
ROR1	4919	broad.mit.edu	37	1	64643444	64643444	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:64643444G>A	uc001dbj.2	+	9	2119	c.1720G>A	c.(1720-1722)GGC>AGC	p.G574S	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	574	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CTCTGATGTTGGCTGCAGCAG	0.483													13	44					0	0	0.013537	0	0	
LRRC8B	23507	broad.mit.edu	37	1	90050004	90050004	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:90050004C>T	uc001dni.2	+	7	2302	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	LRRC8B_uc001dnh.2_Missense_Mutation_p.R599C|LRRC8B_uc001dnj.2_Missense_Mutation_p.R599C	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	599	LRR 6.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TGACCTGGAACGCATCCCACA	0.403													19	53					0	0	0.006122	0	0	
FLG	2312	broad.mit.edu	37	1	152283559	152283559	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:152283559G>T	uc001ezu.1	-	3	3839	c.3803C>A	c.(3802-3804)TCC>TAC	p.S1268Y	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1268	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTAACACTGGATCCCTGGTG	0.468									Ichthyosis				63	192					4.45325e-31	5.59838e-31	0.014410	1	0	
FLG	2312	broad.mit.edu	37	1	152286203	152286203	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:152286203C>T	uc001ezu.1	-	3	1195	c.1159G>A	c.(1159-1161)GGC>AGC	p.G387S	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	387	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGGTGGCCGGATCCATGT	0.582									Ichthyosis				101	309					0	0	0.014410	0	0	
IQGAP3	128239	broad.mit.edu	37	1	156496382	156496382	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:156496382G>T	uc001fpf.2	-	38	4867	c.4792C>A	c.(4792-4794)CAG>AAG	p.Q1598K		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1598					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TACTGGAGCTGCAGGAGATCC	0.493													6	44					0.00198382	0.00209073	0.001984	1	0	
ADCY10	55811	broad.mit.edu	37	1	167874377	167874377	+	Missense_Mutation	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:167874377A>G	uc001ger.2	-	2	300	c.2T>C	c.(1-3)ATG>ACG	p.M1T	ADCY10_uc009wvk.2_5'UTR|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Missense_Mutation_p.M1T|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TGGAGTGTTCATGTTCAAGAC	0.398													20	63					0	0	0.012319	0	0	
HMCN1	83872	broad.mit.edu	37	1	186114580	186114580	+	Missense_Mutation	SNP	G	A	A	rs141397809		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:186114580G>A	uc001grq.1	+	92	14541	c.14312G>A	c.(14311-14313)CGG>CAG	p.R4771Q	HMCN1_uc001grs.1_Missense_Mutation_p.R340Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4771	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACATGCAGCCGGACGTGTAAC	0.552													13	30					0	0	0.001855	0	0	
CFHR3	10878	broad.mit.edu	37	1	196749062	196749062	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:196749062C>T	uc001gtl.2	+	3	476	c.389C>T	c.(388-390)ACG>ATG	p.T130M	CFHR3_uc001gtk.2_Missense_Mutation_p.T130M|CFHR3_uc010poy.1_Missense_Mutation_p.T130M|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	130	Sushi 2.					extracellular space					0						GTTACATGTACGGAGAAAGGC	0.473													13	48					0	0	0.001855	0	0	
PM20D1	148811	broad.mit.edu	37	1	205817084	205817084	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:205817084G>A	uc001hdj.2	-	2	230	c.185C>T	c.(184-186)CCA>CTA	p.P62L	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	62						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGTCACTGTTGGAATCTGGAT	0.403													15	36					0	0	0.004007	0	0	
FMN2	56776	broad.mit.edu	37	1	240371492	240371492	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr1:240371492C>T	uc010pyd.1	+	5	3605	c.3380C>T	c.(3379-3381)GCG>GTG	p.A1127V	FMN2_uc010pye.1_Missense_Mutation_p.A1131V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1127	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTACCCGGAGCGGGCATACCC	0.721													5	18					0	0	0.001984	0	0	
DOCK1	1793	broad.mit.edu	37	10	129179558	129179558	+	Missense_Mutation	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr10:129179558T>C	uc001ljt.2	+	37	3734	c.3670T>C	c.(3670-3672)TGT>CGT	p.C1224R	DOCK1_uc010qun.1_Missense_Mutation_p.C1245R|DOCK1_uc009yaq.2_Missense_Mutation_p.C219R	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1224	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GTACAAGCTCTGTGACCTGCA	0.388													15	50					0	0	0.004990	0	0	
MUC5B	727897	broad.mit.edu	37	11	1263339	1263339	+	Silent	SNP	G	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:1263339G>C	uc009ycr.1	+	47	7434	c.7308G>C	c.(7306-7308)ACG>ACC	p.T2436T	MUC5B_uc001ltb.2_Silent_p.T1746T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1743	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGCTGACCACGAGCCTGGCGC	0.642													7	20					0	0	0.001984	0	0	
APBB1	322	broad.mit.edu	37	11	6432394	6432394	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:6432394G>T	uc001mdb.1	-	2	284	c.184C>A	c.(184-186)CCA>ACA	p.P62T	APBB1_uc001mdc.1_Missense_Mutation_p.P62T|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	62					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCAGGGCCTGGCTCAGGCCCA	0.662													30	109					1.16021e-09	1.33462e-09	0.007291	1	0	
PTPRJ	5795	broad.mit.edu	37	11	48149352	48149352	+	Missense_Mutation	SNP	G	A	A	rs2229703	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:48149352G>A	uc001ngp.3	+	7	1469	c.1114G>A	c.(1114-1116)GTC>ATC	p.V372I	PTPRJ_uc001ngo.3_Missense_Mutation_p.V372I	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	372	Extracellular (Potential).|Fibronectin type-III 4.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity	p.V372L(1)		breast(3)|kidney(3)|ovary(1)|skin(1)	8						GGTTTTTGACGTCACCGCTGT	0.498													13	47					0	0	0.013537	0	0	
OR9G4	283189	broad.mit.edu	37	11	56510343	56510343	+	Silent	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:56510343G>T	uc010rjo.1	-	1	945	c.945C>A	c.(943-945)GCC>GCA	p.A315A		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTTTCCTGAAGGCCTCTTTGA	0.408													25	56					4.26978e-12	5.11211e-12	0.003330	1	0	
BAD	572	broad.mit.edu	37	11	64037700	64037700	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:64037700C>T	uc001nzd.2	-	4	570	c.488G>A	c.(487-489)AGC>AAC	p.S163N	BAD_uc001nzc.2_Missense_Mutation_p.S163N|GPR137_uc009ypj.1_5'UTR	NM_032989	NP_116784	Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	163					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)	1						GGGGGCGGAGCTTCCCCTGCC	0.637													8	31					0	0	0.004482	0	0	
SLC22A12	116085	broad.mit.edu	37	11	64360337	64360337	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:64360337C>T	uc001oam.1	+	2	1236	c.489C>T	c.(487-489)TGC>TGT	p.C163C	SLC22A12_uc009ypr.1_Silent_p.C163C|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Silent_p.C163C|SLC22A12_uc001oan.1_Silent_p.C163C|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	163	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CTGCTGCGTGCGGCCCTGCCT	0.627													15	46					0	0	0.002450	0	0	
CADM1	23705	broad.mit.edu	37	11	115099839	115099839	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:115099839C>A	uc001ppi.3	-	5	844	c.715G>T	c.(715-717)GTA>TTA	p.V239L	CADM1_uc001ppf.3_Missense_Mutation_p.V239L|CADM1_uc001ppk.3_Missense_Mutation_p.V239L|CADM1_uc001ppj.3_Missense_Mutation_p.V239L|CADM1_uc001ppl.2_Missense_Mutation_p.V239L	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	239	Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TCACACTGTACTTCTAGATAC	0.483													9	23					0.00829132	0.00858395	0.008291	1	0	
APOA5	116519	broad.mit.edu	37	11	116661339	116661339	+	Silent	SNP	G	A	A	rs140482460		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:116661339G>A	uc001ppr.2	-	3	614	c.606C>T	c.(604-606)ATC>ATT	p.I202I	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Silent_p.I202I|APOA5_uc009yzf.2_Silent_p.I202I|APOA5_uc009yzg.2_Silent_p.I228I	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	202					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		CGTGGCGCCCGATGCCGCTCA	0.697													7	30					0	0	0.001984	0	0	
GRIK4	2900	broad.mit.edu	37	11	120531035	120531035	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:120531035G>A	uc001pxn.2	+	3	295	c.8G>A	c.(7-9)CGC>CAC	p.R3H	GRIK4_uc009zav.1_Missense_Mutation_p.R3H|GRIK4_uc009zaw.1_Missense_Mutation_p.R3H|GRIK4_uc009zax.1_Missense_Mutation_p.R3H	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	3					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AAGATGCCCCGCGTCTCGGCG	0.637											OREG0021424	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	64					0	0	0.006122	0	0	
GRIK4	2900	broad.mit.edu	37	11	120732714	120732714	+	Missense_Mutation	SNP	A	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:120732714A>T	uc001pxn.2	+	9	1078	c.791A>T	c.(790-792)AAC>ATC	p.N264I	GRIK4_uc009zav.1_Missense_Mutation_p.N264I|GRIK4_uc009zaw.1_Missense_Mutation_p.N264I|GRIK4_uc009zax.1_Missense_Mutation_p.N264I	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	264	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GATCGTGTCAACATCCTGGGA	0.488													145	135					0	0	0.014410	0	0	
ADAMTS8	11095	broad.mit.edu	37	11	130297579	130297579	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr11:130297579C>T	uc001qgg.3	-	1	961	c.603G>A	c.(601-603)CCG>CCA	p.P201P		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	201	Poly-Pro.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGGGCGGTGGCGGCTCGCTAG	0.657													6	11					0	0	0.001168	0	0	
PDZRN4	29951	broad.mit.edu	37	12	41900470	41900470	+	Silent	SNP	T	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:41900470T>A	uc010skn.1	+	4	527	c.459T>A	c.(457-459)CCT>CCA	p.P153P	PDZRN4_uc001rmq.3_Silent_p.P94P|PDZRN4_uc009zjz.2_Silent_p.P92P|PDZRN4_uc001rmr.2_5'Flank	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	352							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTCGTCCACCTACCCCTCCAG	0.493													17	49					0	0	0.004990	0	0	
MAP3K12	7786	broad.mit.edu	37	12	53879109	53879109	+	Silent	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:53879109G>T	uc001sdm.1	-	6	971	c.873C>A	c.(871-873)GTC>GTA	p.V291V	MAP3K12_uc001sdn.1_Silent_p.V324V	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	291	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						ACCAGATGTCGACCTTCTCAG	0.557													25	79					9.57634e-11	1.12362e-10	0.003330	1	0	
MARS	4141	broad.mit.edu	37	12	57898029	57898029	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:57898029C>T	uc001sog.2	+	11	1338	c.1315C>T	c.(1315-1317)CGA>TGA	p.R439*	MARS_uc001sof.1_RNA|MARS_uc010srp.1_Nonsense_Mutation_p.R312*|MARS_uc010srq.1_Nonsense_Mutation_p.R205*	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	439					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TAAAGTCTGCCGATCATGCCC	0.557													5	46					0	0	0.001168	0	0	
OS9	10956	broad.mit.edu	37	12	58109707	58109707	+	Silent	SNP	T	G	G	rs73125477	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:58109707T>G	uc001spj.2	+	6	803	c.744T>G	c.(742-744)CCT>CCG	p.P248P	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Silent_p.P248P|OS9_uc001spl.2_Silent_p.P248P|OS9_uc001spm.2_Silent_p.P248P|OS9_uc001spn.2_Silent_p.P248P|OS9_uc010sry.1_Silent_p.P215P|OS9_uc010srz.1_Silent_p.P189P	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	248					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCTGTCACCCTTCCCTACAGC	0.627													6	66					0	0	0.001984	0	0	
C12orf66	144577	broad.mit.edu	37	12	64587770	64587770	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:64587770C>T	uc001srw.3	-	3	1249	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	C12orf66_uc009zql.2_Missense_Mutation_p.R344H	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	397										ovary(1)	1						AGGTTCCGGGCGGGTTAGGAA	0.448													29	85					0	0	0.009535	0	0	
MGAT4C	25834	broad.mit.edu	37	12	86373542	86373542	+	Missense_Mutation	SNP	G	A	A	rs145801611	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:86373542G>A	uc001tai.3	-	8	2212	c.962C>T	c.(961-963)ACG>ATG	p.T321M	MGAT4C_uc001tal.3_Missense_Mutation_p.T321M|MGAT4C_uc001taj.3_Missense_Mutation_p.T321M|MGAT4C_uc001tak.3_Missense_Mutation_p.T321M|MGAT4C_uc010sum.1_Missense_Mutation_p.T345M|MGAT4C_uc001tah.3_Missense_Mutation_p.T321M	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	321	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						CTTATTCTCCGTCCCTTTGTA	0.403													12	62					0	0	0.001855	0	0	
WSCD2	9671	broad.mit.edu	37	12	108641943	108641943	+	Silent	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:108641943G>T	uc001tms.2	+	9	2265	c.1521G>T	c.(1519-1521)CTG>CTT	p.L507L	WSCD2_uc001tmt.2_Silent_p.L507L|WSCD2_uc001tmu.2_Silent_p.L275L	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	507						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGGACCGGCTGCTCTGTGTGG	0.602													14	29					7.93312e-07	8.67223e-07	0.002450	1	0	
RAP2A	5911	broad.mit.edu	37	13	98116563	98116563	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr13:98116563G>T	uc001vnd.2	+	2	669	c.419G>T	c.(418-420)TGC>TTC	p.C140F		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	140					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			GAGTGGGGCTGCCCCTTTATG	0.488													43	53					6.4771e-29	8.08489e-29	0.010771	1	0	
MYO16	23026	broad.mit.edu	37	13	109792648	109792648	+	Missense_Mutation	SNP	G	T	T	rs145367903		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr13:109792648G>T	uc001vqt.1	+	32	4148	c.4022G>T	c.(4021-4023)AGC>ATC	p.S1341I	MYO16_uc010agk.1_Missense_Mutation_p.S1363I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1341					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GACGACTACAGCACCATGAAG	0.602													11	16					5.50884e-06	5.98491e-06	0.013537	1	0	
PRKD1	5587	broad.mit.edu	37	14	30102110	30102110	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:30102110G>A	uc001wqh.2	-	9	1538	c.1357C>T	c.(1357-1359)CTC>TTC	p.L453F		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	453	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTCTGAAAGAGGGTAATACAT	0.368													29	184					0	0	0.010818	0	0	
BAZ1A	11177	broad.mit.edu	37	14	35224069	35224069	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:35224069G>A	uc001wsk.2	-	26	5006	c.4438C>T	c.(4438-4440)CGT>TGT	p.R1480C	BAZ1A_uc001wsl.2_Missense_Mutation_p.R1448C	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1480	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ACTTTTTCACGAATTATATTT	0.284													10	71					0	0	0.013537	0	0	
LRFN5	145581	broad.mit.edu	37	14	42356169	42356169	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:42356169T>G	uc001wvm.2	+	3	1539	c.341T>G	c.(340-342)ATT>AGT	p.I114S	LRFN5_uc010ana.2_Missense_Mutation_p.I114S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	114	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTGACTAAAATTACAAATGAT	0.353										HNSCC(30;0.082)			16	60					0	0	0.003163	0	0	
FSCB	84075	broad.mit.edu	37	14	44974311	44974311	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:44974311G>A	uc001wvn.2	-	1	2189	c.1880C>T	c.(1879-1881)GCT>GTT	p.A627V		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	627	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GGCCTCCTCAGCTGGTGGAGG	0.632													5	36					0	0	0.001168	0	0	
GNPNAT1	64841	broad.mit.edu	37	14	53251263	53251263	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:53251263C>T	uc001xab.2	-	2	361	c.106G>A	c.(106-108)GGA>AGA	p.G36R		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	36					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					AAGCCTTCTCCAGGATGTGTT	0.408													8	72					0	0	0.004482	0	0	
TMEM90A	646658	broad.mit.edu	37	14	74876050	74876050	+	Missense_Mutation	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:74876050T>C	uc001xpx.2	-	2	646	c.398A>G	c.(397-399)GAT>GGT	p.D133G		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	133					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		CTCCTGGTCATCCTCCTGGTC	0.418													36	90					0	0	0.006999	0	0	
KCNK13	56659	broad.mit.edu	37	14	90651110	90651110	+	Silent	SNP	C	T	T	rs139112374		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:90651110C>T	uc001xye.1	+	2	1432	c.990C>T	c.(988-990)GAC>GAT	p.D330D		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	330	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TAGAGACAGACGGGGTGGCAG	0.622													15	47					0	0	0.002450	0	0	
ADAM6	8755	broad.mit.edu	37	14	106725392	106725392	+	RNA	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:106725392T>C	uc010tyt.1	-	588		c.18155A>G								Parts of antibodies, mostly variable regions.												0						CGGACCCAGCTCATGGCATAG	0.602													51	222					0	0	0.014410	0	0	
SLTM	79811	broad.mit.edu	37	15	59186099	59186099	+	Silent	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:59186099A>G	uc002afp.2	-	12	1657	c.1569T>C	c.(1567-1569)GGT>GGC	p.G523G	SLTM_uc002afn.2_Splice_Site_p.G92_splice|SLTM_uc002afo.2_Silent_p.G505G|SLTM_uc002afq.2_Silent_p.G92G|SLTM_uc010bgd.2_Silent_p.G92G	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	523					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TCTCATCTTTACCTTCTATTT	0.348													44	23					0	0	0.011902	0	0	
DENND4A	10260	broad.mit.edu	37	15	65988761	65988761	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:65988761C>T	uc002aph.2	-	21	3271	c.2893G>A	c.(2893-2895)GTT>ATT	p.V965I	DENND4A_uc002api.2_Missense_Mutation_p.V1008I|DENND4A_uc002apj.3_Missense_Mutation_p.V965I	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GTGAGGCGAACGATACTGGAA	0.383													6	20					0	0	0.001168	0	0	
CORO2B	10391	broad.mit.edu	37	15	69004026	69004026	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:69004026G>A	uc002arj.3	+	5	658	c.629G>A	c.(628-630)CGC>CAC	p.R210H	CORO2B_uc010bic.2_Missense_Mutation_p.R205H|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	210	WD 3.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						ATTGAGCCCCGCTCTGGCCGT	0.557													22	9					0	0	0.003330	0	0	
C15orf42	90381	broad.mit.edu	37	15	90164697	90164697	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr15:90164697G>T	uc002boe.2	+	19	3228	c.3228G>T	c.(3226-3228)ATG>ATT	p.M1076I	C15orf42_uc010upv.1_5'Flank	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1076					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTCTGAGATGATCAGCCCCT	0.423													12	31					1.36491e-13	1.64537e-13	0.001855	1	0	
PKD1	5310	broad.mit.edu	37	16	2143019	2143019	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:2143019C>A	uc002cos.1	-	38	11301	c.11092G>T	c.(11092-11094)GCC>TCC	p.A3698S	PKD1_uc002cot.1_Missense_Mutation_p.A3697S|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3698	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGACGGTAGGCGTGCCCATGG	0.642													24	84					3.7963e-18	4.67237e-18	0.003330	1	0	
TRAP1	10131	broad.mit.edu	37	16	3724366	3724366	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:3724366G>A	uc002cvt.3	-	9	1107	c.1018C>T	c.(1018-1020)CGC>TGC	p.R340C	TRAP1_uc002cvs.2_Missense_Mutation_p.R131C|TRAP1_uc010uxf.1_Missense_Mutation_p.R287C	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	340					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				AAGATGCTGCGGATGTTGAGC	0.607													7	44					0	0	0.003080	0	0	
SEC14L5	9717	broad.mit.edu	37	16	5064914	5064914	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:5064914C>T	uc002cye.2	+	16	2214	c.2034C>T	c.(2032-2034)GCC>GCT	p.A678A		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	678	Ser-rich.					integral to membrane|intracellular	transporter activity				0						AGCTCAGCGCCGCCACCTCGT	0.662													7	27					0	0	0.003080	0	0	
GP2	2813	broad.mit.edu	37	16	20335179	20335179	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:20335179C>A	uc002dgv.2	-	3	577	c.494G>T	c.(493-495)CGG>CTG	p.R165L	GP2_uc002dgw.2_Missense_Mutation_p.R165L|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	165						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						GCCTTCCAACCGGTACACATG	0.577													5	17					1.6384e-10	1.90966e-10	0.001984	1	0	
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	A	A	rs150520281	by1000genomes	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254													4	22					0	0	0.001984	0	0	
NKD1	85407	broad.mit.edu	37	16	50642255	50642255	+	Silent	SNP	C	T	T	rs115028583	by1000genomes	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:50642255C>T	uc002egg.1	+	4	467	c.243C>T	c.(241-243)GAC>GAT	p.D81D		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	81					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AAGAGGAGGACGACTTTCGGC	0.602													23	79					0	0	0.003330	0	0	
NDRG4	65009	broad.mit.edu	37	16	58538551	58538551	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:58538551G>T	uc002eno.2	+	5	476	c.370G>T	c.(370-372)GCA>TCA	p.A124S	NDRG4_uc002enk.2_Missense_Mutation_p.A156S|NDRG4_uc002enm.2_Missense_Mutation_p.A176S|NDRG4_uc010vif.1_Missense_Mutation_p.A156S|NDRG4_uc010cdk.2_Missense_Mutation_p.A142S|NDRG4_uc010vig.1_Missense_Mutation_p.A154S|NDRG4_uc010vih.1_Missense_Mutation_p.A69S|NDRG4_uc010vii.1_Missense_Mutation_p.A142S|NDRG4_uc002enp.2_Missense_Mutation_p.A124S|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	124					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						GGCCAAGTTTGCAGTGAGTCT	0.607													11	37					7.03913e-09	7.99281e-09	0.013537	1	0	
MLKL	197259	broad.mit.edu	37	16	74716642	74716642	+	Missense_Mutation	SNP	A	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:74716642A>C	uc002fdb.2	-	6	1304	c.863T>G	c.(862-864)CTC>CGC	p.L288R	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	288	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						CAGGGTCCCGAGTTCACAGTA	0.557													6	43					0	0	0.001984	0	0	
C16orf46	123775	broad.mit.edu	37	16	81097557	81097557	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr16:81097557C>A	uc002fgc.3	-	3	263	c.4G>T	c.(4-6)GAT>TAT	p.D2Y	C16orf46_uc010chf.2_Missense_Mutation_p.D2Y|C16orf46_uc010vno.1_Intron	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	2											0						TGACAGAGATCCATTACTGTG	0.294													17	46					1.02788e-11	1.21414e-11	0.004990	1	0	
Unknown	0	broad.mit.edu	37	17	20405874	20405874	+	RNA	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:20405874G>A	uc002gxb.2	-	5		c.1145C>T								Homo sapiens similar to Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16), mRNA (cDNA clone IMAGE:4752428).																		TGACTTGGGGGCTGCTGCTGT	0.577													5	51					0	0	0.001168	0	0	
KRT36	8689	broad.mit.edu	37	17	39645762	39645762	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:39645762C>T	uc002hwt.2	-	1	355	c.355G>A	c.(355-357)GCG>ACG	p.A119T		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	119	Rod.|Coil 1A.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TCCAGCTCCGCGTTCTCCCGC	0.572													24	116					0	0	0.014323	0	0	
CD300A	11314	broad.mit.edu	37	17	72470705	72470705	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:72470705G>A	uc002jkv.2	+	3	735	c.414G>A	c.(412-414)GCG>GCA	p.A138A	CD300A_uc002jkw.2_Silent_p.A25A|CD300A_uc010dfr.2_Silent_p.A25A|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	138	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	receptor activity	p.A138A(1)		ovary(1)|skin(1)	2						GTATCACTGCGGCCAAGACCT	0.547													10	42					0	0	0.008291	0	0	
SEC14L1	6397	broad.mit.edu	37	17	75186883	75186883	+	Splice_Site	SNP	A	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr17:75186883A>T	uc002jto.2	+	4	331	c.64_splice	c.e4-2	p.A22_splice	SEC14L1_uc010dhc.2_Splice_Site_p.A22_splice|SEC14L1_uc010wth.1_Splice_Site_p.A22_splice|SEC14L1_uc002jtm.2_Splice_Site_p.A22_splice|SEC14L1_uc010wti.1_Splice_Site	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a						transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						TTAAATTTATAGGCCTATGAA	0.483													18	32					0	0	0.006122	0	0	
PIK3C3	5289	broad.mit.edu	37	18	39570432	39570432	+	Nonsense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:39570432C>T	uc002lap.2	+	6	686	c.628C>T	c.(628-630)CGA>TGA	p.R210*	PIK3C3_uc010xcl.1_Nonsense_Mutation_p.R147*	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	210					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						GAGTGAAAAACGAAGTTCTAA	0.284										TSP Lung(28;0.18)			9	50					0	0	0.004482	0	0	
ST8SIA5	29906	broad.mit.edu	37	18	44272196	44272196	+	Missense_Mutation	SNP	C	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:44272196C>G	uc002lcj.1	-	3	815	c.247G>C	c.(247-249)GAC>CAC	p.D83H	ST8SIA5_uc002lci.1_5'UTR|ST8SIA5_uc010xcy.1_Missense_Mutation_p.D119H|ST8SIA5_uc010xcz.1_Missense_Mutation_p.D52H|ST8SIA5_uc010dno.1_Missense_Mutation_p.D119H	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	83	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						TTCCACCTGTCGAACAGCTCT	0.527													5	35					0	0	0.000602	0	0	
SMAD4	4089	broad.mit.edu	37	18	48593393	48593393	+	Missense_Mutation	SNP	C	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:48593393C>G	uc010xdp.1	+	10	1682	c.1144C>G	c.(1144-1146)CAC>GAC	p.H382D	SMAD4_uc002lfb.3_Missense_Mutation_p.H227D	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	382	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CCTAAGGTTGCACATAGGCAA	0.333									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				16	37					0	0	0.006122	0	0	
NETO1	81832	broad.mit.edu	37	18	70417501	70417501	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr18:70417501T>G	uc002lkw.2	-	9	1621	c.1337A>C	c.(1336-1338)AAC>ACC	p.N446T	NETO1_uc002lkx.1_Missense_Mutation_p.N445T|NETO1_uc002lky.1_Missense_Mutation_p.N446T	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	446	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TGTGCTGAGGTTACTGCGGCT	0.463													12	18					0	0	0.001855	0	0	
ARID3A	1820	broad.mit.edu	37	19	971927	971927	+	Missense_Mutation	SNP	C	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:971927C>G	uc002lql.2	+	9	1934	c.1644C>G	c.(1642-1644)AAC>AAG	p.N548K		NM_005224	NP_005215	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT- like)	548	Important for cytoplasmic localization (By similarity).					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCCCAACAAAGGAggcg	0.532													6	57					0	0	0.001984	0	0	
ADAMTS10	81794	broad.mit.edu	37	19	8668685	8668685	+	Silent	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:8668685T>C	uc002mkj.1	-	5	793	c.519A>G	c.(517-519)GAA>GAG	p.E173E	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	173					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GTGGTCCACTTTCCTCCGGGC	0.597													8	20					0	0	0.003080	0	0	
ZNF491	126069	broad.mit.edu	37	19	11917976	11917976	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:11917976G>T	uc002mso.1	+	3	1493	c.1208G>T	c.(1207-1209)AGA>ATA	p.R403I		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	403	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATACATGAAAGAATTCACACT	0.368													7	30					8.12818e-05	8.72293e-05	0.001984	1	0	
TSHZ3	57616	broad.mit.edu	37	19	31769087	31769087	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:31769087G>T	uc002nsy.3	-	2	1677	c.1612C>A	c.(1612-1614)CAG>AAG	p.Q538K		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	538					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GTGCCGTTCTGGGCCTTGTTG	0.532													9	121					3.09899e-07	3.45203e-07	0.004482	1	0	
TRPM4	54795	broad.mit.edu	37	19	49661469	49661469	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:49661469C>A	uc002pmw.2	+	2	117	c.45C>A	c.(43-45)TTC>TTA	p.F15L	TRPM4_uc010emu.2_Missense_Mutation_p.F15L|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Missense_Mutation_p.F15L|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	15	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCAAGATCTTCAAGAAGAAGA	0.602													46	115					2.74695e-27	3.40467e-27	0.014410	1	0	
VRK3	51231	broad.mit.edu	37	19	50498471	50498471	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:50498471G>A	uc002prg.2	-	8	839	c.741C>T	c.(739-741)TTC>TTT	p.F247F	VRK3_uc002prh.1_Silent_p.F247F|VRK3_uc002pri.1_Silent_p.F197F|VRK3_uc010ens.2_Silent_p.F247F|VRK3_uc010ybl.1_Silent_p.F197F|VRK3_uc010ybm.1_Intron|VRK3_uc002prj.1_Silent_p.F197F|VRK3_uc002prk.1_Silent_p.F247F|VRK3_uc010ent.1_Silent_p.F3F|VRK3_uc002prl.2_Silent_p.F247F|VRK3_uc010ybn.1_Missense_Mutation_p.S225L	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	247	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGTGAACACCGAAACCCATGC	0.562													6	25					0	0	0.001984	0	0	
LRRC4B	94030	broad.mit.edu	37	19	51022345	51022345	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:51022345G>A	uc002pss.2	-	3	762	c.625C>T	c.(625-627)CTG>TTG	p.L209L		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	209	Extracellular (Potential).|LRR 6.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGGTAGCGCAGGTTGACCAGC	0.667													7	17					0	0	0.001984	0	0	
SIGLEC14	100049587	broad.mit.edu	37	19	52149516	52149516	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:52149516C>A	uc002pxf.3	-	2	535	c.415G>T	c.(415-417)GTG>TTG	p.V139L		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	139	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		ATACCTGTCACCTCCAAGTTC	0.557													20	37					1.50538e-07	1.68756e-07	0.006320	1	0	
LILRA3	11026	broad.mit.edu	37	19	54802027	54802027	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:54802027C>T	uc002qfd.2	-	6	1226	c.1161G>A	c.(1159-1161)GTG>GTA	p.V387V	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.V323V	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	387	Ig-like C2-type 4.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGCCGAGGTCACAGGACTCA	0.587													23	99					0	0	0.002780	0	0	
FCAR	2204	broad.mit.edu	37	19	55396777	55396777	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:55396777G>A	uc002qhr.1	+	3	398	c.201G>A	c.(199-201)ACG>ACA	p.T67T	FCAR_uc002qhq.2_Silent_p.T67T|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T40T|FCAR_uc010esi.1_Silent_p.T40T|FCAR_uc002qhu.1_Silent_p.T67T|FCAR_uc002qhv.1_Silent_p.T67T|FCAR_uc002qhw.1_Silent_p.T55T|FCAR_uc002qhx.1_Silent_p.T55T|FCAR_uc002qhy.1_Silent_p.T55T|FCAR_uc002qhz.1_Silent_p.T55T|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	67	Extracellular (Potential).|Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		AAAACTCCACGTACCGAGAGA	0.488													20	49					0	0	0.008871	0	0	
NCR1	9437	broad.mit.edu	37	19	55421410	55421410	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr19:55421410G>A	uc002qib.2	+	5	705	c.667G>A	c.(667-669)GAC>AAC	p.D223N	NCR1_uc002qic.2_Missense_Mutation_p.D223N|NCR1_uc002qie.2_Missense_Mutation_p.D223N|NCR1_uc002qid.2_Missense_Mutation_p.D128N|NCR1_uc002qif.2_Missense_Mutation_p.D128N|NCR1_uc010esj.2_Missense_Mutation_p.D116N	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	223	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TGCACCTGAAGACCCCACCTT	0.438													29	100					0	0	0.006320	0	0	
TXNDC9	10190	broad.mit.edu	37	2	99944024	99944024	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:99944024G>A	uc002szz.2	-	3	473	c.282C>T	c.(280-282)TGC>TGT	p.C94C	TXNDC9_uc010yvp.1_Silent_p.C111C|TXNDC9_uc002taa.1_Silent_p.C94C	NM_005783	NP_005774	O14530	TXND9_HUMAN	thioredoxin domain containing 9	94	Thioredoxin.				cell redox homeostasis		protein binding				0						TGTAGAAATGGCAAACCACAT	0.378													7	57					0	0	0.003080	0	0	
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	G	G	rs115341812	by1000genomes	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567													3	20					0	0	0.004672	0	0	
THSD7B	80731	broad.mit.edu	37	2	138169203	138169203	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:138169203G>A	uc002tva.1	+	13	2627	c.2627G>A	c.(2626-2628)TGC>TAC	p.C876Y	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.C766Y	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAGGAGAAATGCCAGGATTCT	0.373													29	35					0	0	0.007291	0	0	
ZEB2	9839	broad.mit.edu	37	2	145162506	145162506	+	Silent	SNP	G	A	A	rs138859323	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:145162506G>A	uc002tvu.2	-	5	969	c.489C>T	c.(487-489)ATC>ATT	p.I163I	ZEB2_uc002tvv.2_Silent_p.I157I|ZEB2_uc010zbm.1_Silent_p.I134I|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.I192I	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	163						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGTACTCCTCGATGCTGACTG	0.478													3	24					0	0	0.009096	0	0	
NEUROD1	4760	broad.mit.edu	37	2	182542645	182542645	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:182542645C>T	uc002uof.2	-	2	1179	c.943G>A	c.(943-945)GGA>AGA	p.G315R	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	315					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			AAGATTGATCCGTGGCTTTGG	0.512													31	51					0	0	0.009535	0	0	
DNAH7	56171	broad.mit.edu	37	2	196737066	196737066	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:196737066G>A	uc002utj.3	-	40	6642	c.6541C>T	c.(6541-6543)CGT>TGT	p.R2181C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2181	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAGAAATCACGGAGGTTGAAC	0.393													7	96					0	0	0.001984	0	0	
PLCL1	5334	broad.mit.edu	37	2	198948639	198948639	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:198948639G>A	uc010fsp.2	+	2	689	c.398G>A	c.(397-399)CGT>CAT	p.R133H	PLCL1_uc002uuv.3_Missense_Mutation_p.R54H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	133	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ATTTACAACCGTTTTTTCACT	0.443													4	38					0	0	0.009096	0	0	
ERBB4	2066	broad.mit.edu	37	2	212248608	212248608	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:212248608T>G	uc002veg.1	-	28	3757	c.3659A>C	c.(3658-3660)GAG>GCG	p.E1220A	ERBB4_uc002veh.1_Missense_Mutation_p.E1204A|ERBB4_uc010zji.1_Missense_Mutation_p.E1210A|ERBB4_uc010zjj.1_Missense_Mutation_p.E1194A	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1220	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CTTCAGGTACTCAGCTTTTCC	0.502										TSP Lung(8;0.080)			13	158					0	0	0.002450	0	0	
SPEG	10290	broad.mit.edu	37	2	220329225	220329225	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:220329225C>T	uc010fwg.2	+	9	2776	c.2776C>T	c.(2776-2778)CGG>TGG	p.R926W	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Missense_Mutation_p.R134W|SPEG_uc002vln.1_Missense_Mutation_p.R134W|SPEG_uc002vlp.1_Missense_Mutation_p.R134W|SPEG_uc002vlq.2_Missense_Mutation_p.R77W	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	926	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGGGCTGTGCCGGCTGCGGAT	0.647													25	36					0	0	0.002780	0	0	
SLC19A3	80704	broad.mit.edu	37	2	228566967	228566967	+	Missense_Mutation	SNP	C	A	A	rs121917882		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:228566967C>A	uc002vpi.2	-	2	157	c.68G>T	c.(67-69)GGT>GTT	p.G23V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_5'UTR	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	23	Helical; (Potential).		G -> V (in BBGD).		thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	GGAGAAAAAACCAAATAAGCA	0.393													10	74					2.80697e-09	3.20797e-09	0.010729	1	0	
TRIP12	9320	broad.mit.edu	37	2	230664072	230664072	+	Missense_Mutation	SNP	T	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr2:230664072T>A	uc002vpw.1	-	21	3118	c.3009A>T	c.(3007-3009)AAA>AAT	p.K1003N	TRIP12_uc002vpx.1_Missense_Mutation_p.K1051N|TRIP12_uc002vpy.1_Missense_Mutation_p.K733N|TRIP12_uc010zlz.1_Intron	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1003					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTGGCAGTCGTTTTCTCTTTA	0.393													4	58					0	0	0.000602	0	0	
PIWIL3	440822	broad.mit.edu	37	22	25153973	25153973	+	Missense_Mutation	SNP	T	C	C	rs142994368	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr22:25153973T>C	uc003abd.1	-	4	674	c.257A>G	c.(256-258)CAT>CGT	p.H86R	PIWIL3_uc011ajx.1_5'UTR|PIWIL3_uc011ajy.1_5'UTR|PIWIL3_uc010gut.1_Missense_Mutation_p.H86R	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	86					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						GGGCGCTGTATGCAACCCAGC	0.438													53	181					0	0	0.014410	0	0	
CHL1	10752	broad.mit.edu	37	3	407660	407660	+	Missense_Mutation	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:407660A>G	uc003bou.2	+	14	1836	c.1565A>G	c.(1564-1566)AAG>AGG	p.K522R	CHL1_uc003bot.2_Missense_Mutation_p.K538R|CHL1_uc003bow.1_Missense_Mutation_p.K522R|CHL1_uc011asi.1_Missense_Mutation_p.K538R|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	522	Ig-like C2-type 6.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GTTTCTCCTAAGAATCCTCGT	0.338													4	22					0	0	0.009096	0	0	
GRM7	2917	broad.mit.edu	37	3	7456790	7456790	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:7456790T>G	uc003bqm.2	+	5	1388	c.1114T>G	c.(1114-1116)TTC>GTC	p.F372V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.F372V|GRM7_uc003bql.2_Missense_Mutation_p.F372V|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	372	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGAGGAAAACTTCAACTGCAA	0.388													20	35					0	0	0.008871	0	0	
IL17RC	84818	broad.mit.edu	37	3	9971770	9971770	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:9971770C>A	uc003bua.2	+	14	1664	c.1428C>A	c.(1426-1428)GAC>GAA	p.D476E	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcs.2_Missense_Mutation_p.D380E|IL17RC_uc003btz.2_Missense_Mutation_p.D405E|IL17RC_uc011atp.1_Missense_Mutation_p.D244E|IL17RC_uc003bud.2_Intron|IL17RC_uc003bub.2_Missense_Mutation_p.D390E|IL17RC_uc010hct.2_Missense_Mutation_p.D405E|IL17RC_uc010hcu.2_Missense_Mutation_p.D388E|IL17RC_uc010hcv.2_Missense_Mutation_p.D373E|IL17RC_uc011atq.1_Missense_Mutation_p.D390E|IL17RC_uc003buc.2_5'UTR|IL17RC_uc003bue.2_Missense_Mutation_p.D41E	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	476	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCCCCCAGGACAACAGATCCC	0.587													14	48					7.93312e-07	8.67223e-07	0.002450	1	0	
RFTN1	23180	broad.mit.edu	37	3	16475457	16475457	+	Nonsense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:16475457G>T	uc003cay.2	-	3	515	c.233C>A	c.(232-234)TCG>TAG	p.S78*	RFTN1_uc010hes.2_Nonsense_Mutation_p.S42*	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	78						plasma membrane				ovary(3)|central_nervous_system(1)	4						GGCCGCCAGCGAGAAGCCCTG	0.652													23	53					1.10923e-09	1.28437e-09	0.002780	1	0	
GRM2	2912	broad.mit.edu	37	3	51749520	51749520	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:51749520C>T	uc010hlv.2	+	4	1970	c.1731C>T	c.(1729-1731)CTC>CTT	p.L577L	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	577	Helical; Name=1; (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCGCCTGCCTCGGTGCCCTGG	0.637													19	48					0	0	0.007413	0	0	
POLQ	10721	broad.mit.edu	37	3	121228447	121228447	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:121228447C>A	uc003eee.3	-	12	2049	c.1920G>T	c.(1918-1920)AAG>AAT	p.K640N		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	640					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAACAAAGCCCTTCATTGCTC	0.343								DNA_polymerases_(catalytic_subunits)					10	63					1.76689e-08	1.99342e-08	0.006214	1	0	
XRN1	54464	broad.mit.edu	37	3	142031582	142031582	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:142031582G>A	uc003eus.2	-	41	4743	c.4676C>T	c.(4675-4677)TCG>TTG	p.S1559L	XRN1_uc010huu.2_Missense_Mutation_p.S1013L|XRN1_uc003eut.2_Missense_Mutation_p.S1546L|XRN1_uc003euu.2_Missense_Mutation_p.S1547L	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1559					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						GAGATGAGACGACGAAGGCAT	0.443													14	102					0	0	0.001855	0	0	
P2RY1	5028	broad.mit.edu	37	3	152554180	152554180	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:152554180C>T	uc003ezq.2	+	1	1445	c.609C>T	c.(607-609)TAC>TAT	p.Y203Y		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	203	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TCACCTGTTACGACACCACCT	0.537													50	44					0	0	0.014410	0	0	
CCDC50	152137	broad.mit.edu	37	3	191107374	191107374	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr3:191107374C>T	uc003fsw.2	+	10	1474	c.884C>T	c.(883-885)TCA>TTA	p.S295L	CCDC50_uc003fsv.2_Missense_Mutation_p.S471L	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	295						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		TTCTCAAAATCAGAGTCCTCT	0.388													35	85					0	0	0.012213	0	0	
GPRIN3	285513	broad.mit.edu	37	4	90169424	90169424	+	Missense_Mutation	SNP	C	T	T	rs148884438		TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr4:90169424C>T	uc003hsm.1	-	2	2357	c.1838G>A	c.(1837-1839)GGT>GAT	p.G613D		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	613										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GCTGGAGTCACCCATGGGATC	0.582													4	60					0	0	0.000602	0	0	
SLC9A3	6550	broad.mit.edu	37	5	488520	488520	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:488520C>T	uc003jbe.2	-	3	698	c.586G>A	c.(586-588)GTC>ATC	p.V196I	SLC9A3_uc011clx.1_Missense_Mutation_p.V196I	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	196	Helical; Name=F/M5A; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACGGCCAGGACGGCCACCGGG	0.642													3	16					0	0	0.004672	0	0	
ENC1	8507	broad.mit.edu	37	5	73931384	73931384	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:73931384C>T	uc003kdc.3	-	2	2058	c.927G>A	c.(925-927)AAG>AAA	p.K309K	ENC1_uc011css.1_Silent_p.K236K	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	309	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CCAGATACAACTTGTCACACA	0.507													6	57					0	0	0.001984	0	0	
DMGDH	29958	broad.mit.edu	37	5	78338268	78338268	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:78338268C>A	uc003kfs.2	-	7	1037	c.1031G>T	c.(1030-1032)CGA>CTA	p.R344L	DMGDH_uc011cte.1_Missense_Mutation_p.R194L|DMGDH_uc011ctf.1_Missense_Mutation_p.R143L|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	344					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TTCCATGATTCGATCTAGATC	0.428													8	59					0.00307968	0.00322633	0.003080	1	0	
DMXL1	1657	broad.mit.edu	37	5	118484637	118484637	+	Missense_Mutation	SNP	A	T	T	rs149431940	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:118484637A>T	uc003ksd.2	+	18	3296	c.3115A>T	c.(3115-3117)AGT>TGT	p.S1039C	DMXL1_uc010jcl.1_Missense_Mutation_p.S1039C	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1039										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAGCAATAGTAGTATAACTGT	0.398													9	122					0	0	0.004482	0	0	
PCDHB9	56127	broad.mit.edu	37	5	140567301	140567301	+	Missense_Mutation	SNP	G	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:140567301G>C	uc003liw.1	+	1	409	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	137	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCACAAAGAGATGGTCTT	0.403													22	35					0	0	0.010504	0	0	
TCERG1	10915	broad.mit.edu	37	5	145838886	145838886	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr5:145838886C>T	uc003lob.2	+	4	918	c.878C>T	c.(877-879)GCG>GTG	p.A293V	TCERG1_uc003loc.2_Missense_Mutation_p.A293V|TCERG1_uc011dbt.1_Missense_Mutation_p.A293V	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	293	Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTTCAGTTGCGCAGACAGTA	0.463													10	75					0	0	0.008291	0	0	
FKSG83	83954	broad.mit.edu	37	6	27293549	27293549	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:27293549C>T	uc010jqt.2	+	1	972	c.488C>T	c.(487-489)TCC>TTC	p.S163F	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	163						integral to membrane	pheromone receptor activity				0						ATGATTATTTCCCCCTGCTTA	0.294													8	15					0	0	0.006214	0	0	
VARS2	57176	broad.mit.edu	37	6	30890881	30890881	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:30890881C>T	uc003nsc.1	+	23	2818	c.2186C>T	c.(2185-2187)GCG>GTG	p.A729V	VARS2_uc011dmx.1_Missense_Mutation_p.A729V|VARS2_uc011dmy.1_Missense_Mutation_p.A589V|VARS2_uc011dmz.1_Missense_Mutation_p.A759V|VARS2_uc011dna.1_Missense_Mutation_p.A727V|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.A167V|VARS2_uc010jsg.1_Missense_Mutation_p.A101V|VARS2_uc010jsh.1_5'UTR	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	729					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						TCCCTTCCAGCGGGCGACTTG	0.582													19	87					0	0	0.006122	0	0	
C6orf27	80737	broad.mit.edu	37	6	31733757	31733757	+	Missense_Mutation	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:31733757A>G	uc011dog.1	-	16	2640	c.2402T>C	c.(2401-2403)GTG>GCG	p.V801A		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	801						extracellular region				ovary(3)	3						CACCATCACCACGGAATCCGG	0.647													29	139					0	0	0.007291	0	0	
TRERF1	55809	broad.mit.edu	37	6	42227349	42227349	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:42227349G>A	uc003osd.2	-	9	2560	c.1997C>T	c.(1996-1998)CCG>CTG	p.P666L	TRERF1_uc011duq.1_Missense_Mutation_p.P583L|TRERF1_uc003osb.2_Missense_Mutation_p.P422L|TRERF1_uc003osc.2_Missense_Mutation_p.P422L|TRERF1_uc003ose.2_Missense_Mutation_p.P686L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	666	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTAGGAGGGCGGCGGCGGGAT	0.672													8	40					0	0	0.003080	0	0	
ENPP5	59084	broad.mit.edu	37	6	46135702	46135702	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:46135702G>A	uc003oxz.1	-	2	506	c.298C>T	c.(298-300)CGG>TGG	p.R100W	ENPP5_uc003oya.1_Missense_Mutation_p.R100W|ENPP5_uc011dvz.1_Missense_Mutation_p.R6W|ENPP5_uc010jzc.1_Missense_Mutation_p.R100W	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	100						extracellular region|integral to membrane	hydrolase activity				0						GATTTGTTCCGAATAGGATCA	0.378													18	45					0	0	0.008871	0	0	
KIAA1586	57691	broad.mit.edu	37	6	56918804	56918804	+	Missense_Mutation	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:56918804T>C	uc003pdj.2	+	4	1677	c.1507T>C	c.(1507-1509)TAT>CAT	p.Y503H	KIAA1586_uc011dxm.1_Missense_Mutation_p.Y476H	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	503							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TCCTATATTATATATGCATTT	0.348													7	37					0	0	0.003080	0	0	
RIMS1	22999	broad.mit.edu	37	6	72678732	72678732	+	Missense_Mutation	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:72678732A>G	uc003pga.2	+	2	288	c.211A>G	c.(211-213)AGA>GGA	p.R71G		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	71	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAAACACCAAGAAATGCTGA	0.453													22	71					0	0	0.014323	0	0	
SNX14	57231	broad.mit.edu	37	6	86303411	86303411	+	Missense_Mutation	SNP	C	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:86303411C>G	uc003pkr.2	-	1	219	c.26G>C	c.(25-27)GGG>GCG	p.G9A	SNX14_uc011dzg.1_Intron|SNX14_uc003pks.2_Missense_Mutation_p.G9A|SNX14_uc003pkt.2_Missense_Mutation_p.G9A	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	9					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CAGCTTCTGCCCCATCGTCCG	0.672													5	24					0	0	0.000602	0	0	
EPDR1	54749	broad.mit.edu	37	7	37989889	37989889	+	Missense_Mutation	SNP	C	T	T	rs147990215	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:37989889C>T	uc003tfp.2	+	3	945	c.926C>T	c.(925-927)ACG>ATG	p.T309M	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Missense_Mutation_p.T128M	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	189					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						ATATTGTCTACGCGGTTTTTT	0.463													10	33					0	0	0.006214	0	0	
TNS3	64759	broad.mit.edu	37	7	47343060	47343060	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:47343060G>T	uc003tnv.2	-	22	3312	c.2945C>A	c.(2944-2946)TCC>TAC	p.S982Y	TNS3_uc003tnw.2_Missense_Mutation_p.S982Y	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	982						focal adhesion	protein binding			ovary(4)	4						CAGCACTGGGGAGTCCTTCCT	0.672													5	25					3.59834e-05	3.88532e-05	0.001168	1	0	
FZD1	8321	broad.mit.edu	37	7	90895695	90895695	+	Silent	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:90895695T>C	uc003ula.2	+	1	1913	c.1500T>C	c.(1498-1500)TTT>TTC	p.F500F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	500	Helical; Name=5; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGTACCTGTTTATCGGCACGT	0.602													6	99					0	0	0.001168	0	0	
WDR91	29062	broad.mit.edu	37	7	134889047	134889047	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:134889047C>T	uc003vsp.2	-	6	926	c.864G>A	c.(862-864)TCG>TCA	p.S288S	WDR91_uc010lmq.2_5'UTR|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	288										breast(2)|ovary(1)|skin(1)	4						CTTTCTTGGCCGAGCTCTGAG	0.592													12	14					0	0	0.013537	0	0	
TMEM213	155006	broad.mit.edu	37	7	138487766	138487766	+	Missense_Mutation	SNP	C	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:138487766C>A	uc010lna.2	+	3	387	c.276C>A	c.(274-276)GAC>GAA	p.D92E	TMEM213_uc010lnb.2_Missense_Mutation_p.D91E	NM_001085429	NP_001078898	A2RRL7	TM213_HUMAN	transmembrane protein 213	92	Cytoplasmic (Potential).					integral to membrane					0						TCTGTGTGGACAAACTGATGA	0.587													6	12					5.9392e-07	6.57421e-07	0.001168	1	0	
TAS2R41	259287	broad.mit.edu	37	7	143175728	143175728	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:143175728G>A	uc003wdc.1	+	1	763	c.763G>A	c.(763-765)GCA>ACA	p.A255T	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	255	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CATTGATGCCGCAAAATTTAT	0.493													5	49					0	0	0.000602	0	0	
SLC4A2	6522	broad.mit.edu	37	7	150772385	150772385	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr7:150772385G>A	uc003wit.3	+	20	3347	c.3091G>A	c.(3091-3093)GGC>AGC	p.G1031S	SLC4A2_uc011kve.1_Missense_Mutation_p.G1022S|SLC4A2_uc003wiu.3_Missense_Mutation_p.G1017S|SLC4A2_uc003wiv.3_Missense_Mutation_p.G225S|uc011kvf.1_Silent_p.A167A	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1031	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGGGCTCCGGCTTCCACCT	0.642													6	16					0	0	0.001168	0	0	
DDHD2	23259	broad.mit.edu	37	8	38095671	38095671	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:38095671G>A	uc003xlb.2	+	5	943	c.566G>A	c.(565-567)GGT>GAT	p.G189D	DDHD2_uc003xla.2_Missense_Mutation_p.G189D|DDHD2_uc003xlc.2_Missense_Mutation_p.G189D|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	189					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			ACGGAGCAGGGTCGACCAAGA	0.403													16	46					0	0	0.006122	0	0	
RBM12B	389677	broad.mit.edu	37	8	94746335	94746335	+	Silent	SNP	T	C	C			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:94746335T>C	uc003yfz.2	-	3	2497	c.2304A>G	c.(2302-2304)CCA>CCG	p.P768P		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	768							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TGAAATGCTCTGGGGGTGGCC	0.677													17	64					0	0	0.010504	0	0	
RBM12B	389677	broad.mit.edu	37	8	94746349	94746349	+	Silent	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:94746349T>G	uc003yfz.2	-	3	2483	c.2290A>C	c.(2290-2292)AGG>CGG	p.R764R		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	764							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGTGGCCGCCTGAAGTGCTCT	0.677													9	76					0	0	0.013537	0	0	
TSPYL5	85453	broad.mit.edu	37	8	98289373	98289373	+	Nonsense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:98289373G>A	uc003yhy.2	-	1	804	c.700C>T	c.(700-702)CGA>TGA	p.R234*		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	234					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					TGCTGCAGTCGCAACTGCCCA	0.567													13	47					0	0	0.013537	0	0	
CSMD3	114788	broad.mit.edu	37	8	113332148	113332148	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr8:113332148C>T	uc003ynu.2	-	46	7387	c.7228G>A	c.(7228-7230)GAT>AAT	p.D2410N	CSMD3_uc003yns.2_Missense_Mutation_p.D1612N|CSMD3_uc003ynt.2_Missense_Mutation_p.D2370N|CSMD3_uc011lhx.1_Missense_Mutation_p.D2306N|CSMD3_uc003ynw.1_Missense_Mutation_p.D121N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2410	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTCATCATCTTCCGTCAAA	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	46					0	0	0.010504	0	0	
CYLC2	1539	broad.mit.edu	37	9	105767544	105767544	+	Missense_Mutation	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:105767544G>A	uc004bbs.2	+	5	701	c.631G>A	c.(631-633)GGA>AGA	p.G211R		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	211	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.|2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AGGTGAAAAAGGAGGTACAGA	0.279													8	16					0	0	0.003080	0	0	
SVEP1	79987	broad.mit.edu	37	9	113173397	113173397	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:113173397C>T	uc010mtz.2	-	37	6931	c.6594G>A	c.(6592-6594)ACG>ACA	p.T2198T	SVEP1_uc010mty.2_Silent_p.T124T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2198	Sushi 13.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCGGGTGGCACGTCGGTATAG	0.522													10	32					0	0	0.008291	0	0	
CERCAM	51148	broad.mit.edu	37	9	131186739	131186739	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:131186739C>T	uc004buz.3	+	5	1010	c.612C>T	c.(610-612)CGC>CGT	p.R204R	CERCAM_uc004buy.1_Silent_p.R126R|CERCAM_uc010mxz.2_Silent_p.R126R|CERCAM_uc010mya.1_Silent_p.R45R	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	204					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						ACCGCCAGCGCCGGGGCTGCT	0.647													22	86					0	0	0.014323	0	0	
COL5A1	1289	broad.mit.edu	37	9	137708924	137708924	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr9:137708924G>T	uc004cfe.2	+	53	4557	c.4175G>T	c.(4174-4176)AGG>ATG	p.R1392M		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1392	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCAGGAAAAAGGGTAAATAAT	0.572													8	30					0.000157383	0.000167876	0.003080	1	0	
CCNB3	85417	broad.mit.edu	37	X	50085293	50085293	+	Silent	SNP	A	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:50085293A>G	uc004dox.3	+	9	3907	c.3609A>G	c.(3607-3609)TTA>TTG	p.L1203L	CCNB3_uc004doy.2_Silent_p.L1203L|CCNB3_uc004doz.2_Silent_p.L99L|CCNB3_uc010njq.2_Silent_p.L95L|CCNB3_uc004dpa.2_Silent_p.L42L	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1203					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AGGATAAGTTACAACTCCTTG	0.473													20	13					0	0	0.008871	0	0	
HEPH	9843	broad.mit.edu	37	X	65483491	65483491	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:65483491T>G	uc011moz.1	+	20	3274	c.3214T>G	c.(3214-3216)TTA>GTA	p.L1072V	HEPH_uc004dwn.2_Missense_Mutation_p.L1072V|HEPH_uc004dwo.2_Missense_Mutation_p.L802V|HEPH_uc010nkr.2_Missense_Mutation_p.L880V|HEPH_uc011mpa.1_Missense_Mutation_p.L1072V	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1069	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						ACCAGAACACTTAAGCCCTCT	0.438													23	24					0	0	0.005443	0	0	
AR	367	broad.mit.edu	37	X	66765882	66765882	+	Silent	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:66765882C>T	uc004dwu.1	+	1	2009	c.894C>T	c.(892-894)AGC>AGT	p.S298S	AR_uc011mpd.1_Silent_p.S298S|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.S298S	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	296	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TAGACGACAGCGCAGGCAAGA	0.572									Androgen_Insensitivity_Syndrome				9	11					0	0	0.006214	0	0	
KLHL4	56062	broad.mit.edu	37	X	86877278	86877278	+	Missense_Mutation	SNP	T	G	G			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:86877278T>G	uc004efb.2	+	5	1174	c.992T>G	c.(991-993)CTT>CGT	p.L331R	KLHL4_uc004efa.2_Missense_Mutation_p.L331R	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	331						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATTTCAAAACTTCTGTGCAGT	0.398													13	7					0	0	0.001855	0	0	
AKAP14	158798	broad.mit.edu	37	X	119037549	119037549	+	Silent	SNP	G	A	A			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:119037549G>A	uc004ese.2	+	4	399	c.261G>A	c.(259-261)TCG>TCA	p.S87S	AKAP14_uc004esd.2_Silent_p.S87S|AKAP14_uc004esf.2_Silent_p.S87S	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	87						cytoplasm					0						AATATTTTTCGGTAAGTTAGG	0.413													16	9					0	0	0.003163	0	0	
ZNF75D	7626	broad.mit.edu	37	X	134426308	134426308	+	Missense_Mutation	SNP	G	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:134426308G>T	uc004eyp.2	-	4	3158	c.503C>A	c.(502-504)CCA>CAA	p.P168Q	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	168					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CACACCCATTGGTTGGGGCTC	0.507													26	23					4.87955e-14	5.92277e-14	0.005443	1	0	
PNMA5	114824	broad.mit.edu	37	X	152159886	152159886	+	Missense_Mutation	SNP	C	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chrX:152159886C>T	uc010ntw.2	-	3	596	c.257G>A	c.(256-258)GGT>GAT	p.G86D	PNMA5_uc004fha.3_Missense_Mutation_p.G86D|PNMA5_uc010ntx.2_Missense_Mutation_p.G86D|PNMA5_uc004fgy.3_Missense_Mutation_p.G86D	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	86					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ccaggagccaccctttcctgg	0													37	31					0	0	0.004878	0	0	
ABCC9	10060	broad.mit.edu	37	12	22059168	22059169	+	Frame_Shift_Ins	INS	-	T	T			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr12:22059168_22059169insT	uc001rfi.1	-	10	1529_1530	c.1509_1510insA	c.(1507-1512)AAACTTfs	p.K503fs	ABCC9_uc001rfh.2_Frame_Shift_Ins_p.K503fs|ABCC9_uc001rfj.1_Frame_Shift_Ins_p.K503fs	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	503_504	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATTTTAGAAGTTTGATGCCTT	0.337													13	24	---	---	---	---						.
ZDHHC22	283576	broad.mit.edu	37	14	77600151	77600151	+	Frame_Shift_Del	DEL	C	-	-			TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr14:77600151delC	uc010asp.2	-	3	870	c.667delG	c.(667-669)GTGfs	p.V223fs		NM_174976	NP_777636	Q8N966	ZDH22_HUMAN	zinc finger, DHHC domain containing 22	223						integral to membrane	acyltransferase activity|zinc ion binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		CTCACTGCCACCCCCTTCCGC	0.652													10	8	---	---	---	---						.
HIST1H4H	8365	broad.mit.edu	37	6	26285503	26285504	+	Frame_Shift_Del	DEL	CT	-	-	rs41266829	byFrequency	TCGA-IN-8462-01A-11D-2340-08	TCGA-IN-8462-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	c924532b-9a64-43cd-8d71-30c832d3214d	eb8505c1-8121-4be9-9e58-889c9d7cb1e0	g.chr6:26285503_26285504delCT	uc003nhm.2	-	1	224_225	c.224_225delAG	c.(223-225)GAGfs	p.E75fs	HIST1H4H_uc003nhl.1_RNA	NM_003543	NP_003534	P62805	H4_HUMAN	histone cluster 1, H4h	75					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GTTTGGCGTGCTCTGTGTAAGT	0.550										HNSCC(76;0.23)			21	43	---	---	---	---						.
