Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DSCR6	53820	broad.mit.edu	37	21	38390374	38390374	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr21:38390374G>C	uc002yvv.3	+	3	650	c.440G>C	c.(439-441)gGc>gCc	p.G147A	DSCR6_uc011aec.2_Missense_Mutation_p.A34P|DSCR6_uc010gnd.3_Missense_Mutation_p.A34P	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Homo sapiens Down syndrome critical region gene 6 (DSCR6), mRNA.	147						nucleus				NS(1)|breast(1)|kidney(2)|lung(3)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(46;0.0632)				CAGGAAAATGGCCCAGGGGGA	0.632000													16	17					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	123855466	123855466	+	Silent	SNP	G	G	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:123855466G>T	uc003iez.4	+	4	793	c.720G>T	c.(718-720)ctG>ctT	p.L240L	SPATA5_uc003iey.3_Silent_p.L239L	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	Homo sapiens spermatogenesis associated 5 (SPATA5), mRNA.	240					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						AGTTAGATCTGGAGGATACCC	0.428000													23	29					0	0	1	0	0
FAM5C	339479	broad.mit.edu	37	1	190067523	190067523	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:190067523C>T	uc001gse.1	-	7	2158	c.1926G>A	c.(1924-1926)gaG>gaA	p.E642E	FAM5C_uc010pot.1_Silent_p.E540E	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	Homo sapiens family with sequence similarity 5, member C (FAM5C), mRNA.	642						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGTAAATGCTCTCATTACCAT	0.418000													101	5					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10711029	10711029	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:10711029G>A	uc001aro.3	-	11	3105	c.2785C>T	c.(2785-2787)Cgc>Tgc	p.R929C	CASZ1_uc001arp.1_Missense_Mutation_p.R929C	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	Homo sapiens castor zinc finger 1 (CASZ1), transcript variant 1, mRNA.	929					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCTAGACTGCGGTCCTGGGAG	0.711000													8	19					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936095	178936095	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:178936095A>G	uc003fjk.3	+	9	1794	c.1637A>G	c.(1636-1638)cAg>cGg	p.Q546R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	Homo sapiens phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA), mRNA.	546	PI3K helical.		Q -> E (in cancer).|Q -> K (in cancer).|Q -> P (in cancer).|Q -> R (in cancer).		T cell costimulation|T cell receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(1071)|p.E545A(96)|p.Q546K(94)|p.E545G(79)|p.Q546R(58)|p.Q546P(33)|p.E545D(23)|p.E545Q(21)|p.E545?(19)|p.Q546E(12)|p.Q546L(11)|p.E545V(6)|p.Q546H(5)|p.(542_545)E>K(4)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCACTGAGCAGGAGAAAGAT	0.363000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	19					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64453157	64453157	+	Silent	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:64453157G>A	uc021qkw.1	-	5	1575	c.1113C>T	c.(1111-1113)aaC>aaT	p.N371N	NRXN2_uc021qkx.1_Silent_p.N347N|NRXN2_uc001oas.3_Silent_p.N347N|NRXN2_uc001oaq.3_Silent_p.N45N	NM_015080	NP_055895	Q9P2S2	NRX2A_HUMAN	Homo sapiens neurexin 2 (NRXN2), transcript variant alpha-1, mRNA.	371	Laminin G-like 2.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CGTGCCAGGCGTTGTCGTTGA	0.592000													62	65					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531787	140531787	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:140531787G>C	uc003lir.3	+	0	1949	c.1949G>C	c.(1948-1950)cGc>cCc	p.R650P		NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	Homo sapiens protocadherin beta 6 (PCDHB6), mRNA.	650	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCCTCCGCGCTCGGCCACC	0.701000													44	40					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142562260	142562260	+	Silent	SNP	C	C	A	rs148221019		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:142562260C>A	uc011kst.2	+	6	1489	c.702C>A	c.(700-702)gcC>gcA	p.A234A	EPHB6_uc011ksu.2_Silent_p.A234A|EPHB6_uc003wbs.3_5'UTR|EPHB6_uc003wbt.3_Intron|EPHB6_uc003wbu.3_5'UTR|EPHB6_uc003wbv.3_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	Homo sapiens EPH receptor B6 (EPHB6), mRNA.	234	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CCTGCCCTGCCGTGCTCCGAT	0.667000													41	78					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789392	21789392	+	Missense_Mutation	SNP	G	G	A	rs72657369		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:21789392G>A	uc003svc.3	+	53	8822	c.8791G>A	c.(8791-8793)Gtg>Atg	p.V2931M		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	Homo sapiens dynein, axonemal, heavy chain 11 (DNAH11), mRNA.	2931	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GAGCTTCCTCGTGCTGATTAA	0.428000									Kartagener syndrome				21	17					0	0	1	0	0
ICAM4	3386	broad.mit.edu	37	19	10398002	10398002	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:10398002G>C	uc002mnr.2	+	0	360	c.314G>C	c.(313-315)aGg>aCg	p.R105T	ICAM4_uc002mns.2_Missense_Mutation_p.R105T|ICAM4_uc002mnt.2_Missense_Mutation_p.R105T|ICAM5_uc002mnu.4_5'Flank	NM_001039132	NP_001034221	Q14773	ICAM4_HUMAN	Homo sapiens intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ICAM4), transcript variant 3, mRNA.	105	Ig-like C2-type 1.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CTCGACGTGAGGGCCTGGAGC	0.667000													10	29					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31835102	31835102	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr13:31835102C>T	uc010aaz.3	+	6	589	c.479C>T	c.(478-480)gCa>gTa	p.A160V	B3GALTL_uc001utn.4_Non-coding_Transcript	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	Homo sapiens beta 1,3-galactosyltransferase-like (B3GALTL), mRNA.	160					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		TTGGGAAAAGCATTACATGAT	0.348000													7	8					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124006949	124006949	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:124006949C>G	uc001pzu.3	+	12	1682	c.1473C>G	c.(1471-1473)atC>atG	p.I491M	VWA5A_uc001pzt.3_Missense_Mutation_p.I491M	NM_001130142	NP_055437	O00534	VMA5A_HUMAN	Homo sapiens von Willebrand factor A domain containing 5A (VWA5A), transcript variant 3, mRNA.	491								p.I491I(2)|p.V490I(1)		autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						AGACTGTCATCTTTAGGGGTC	0.493000													26	39					0	0	1	0	0
ANKRD20A2	441430	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:95522815A>G	uc010fhp.3	-	0		c.6T>C						Q5SQ80	A20A2_HUMAN	Homo sapiens ankyrin repeat domain 20 family, member A8, pseudogene (ANKRD20A8P), non-coding RNA.											large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	4						ATCTTCTGCAATTCGGAGTCC	0.652000													4	87					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367311	142367311	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:142367311C>T	uc022bby.1	-	0	713	c.713G>A	c.(712-714)cGg>cAg	p.R238Q	GPR20_uc003ywf.3_Missense_Mutation_p.R238Q	NM_005293	NP_005284	Q99678	GPR20_HUMAN	Homo sapiens G protein-coupled receptor 20 (GPR20), mRNA.	238						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CTGCATGGCCCGCACGCGGCG	0.667000													3	23					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962715	41962715	+	RNA	SNP	A	A	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr9:41962715A>T	uc004aca.4	-	2		c.794T>A								Homo sapiens keratinocyte growth factor-like protein 2 (KGFLP2), non-coding RNA.																		CCAGAATTAGATCTTTGAAGT	0.353000													3	11					0	0	1	0	0
LOC100233156	100233156	broad.mit.edu	37	GL000218.1	40869	40869	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chrGL000218.1:40869G>A	uc011mfn.2	-	2	150	c.61C>T	c.(61-63)Cgc>Tgc	p.R21C	LOC100233156_uc003jah.2_Missense_Mutation_p.R21C					Homo sapiens tektin 4 pseudogene (LOC100233156), transcript variant 1, non-coding RNA.																		GAGGCGCTGCGGGGCTGGGGA	0.682000													3	8					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110754451	110754451	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:110754451C>T	uc009wfr.3	+	0	1116	c.330C>T	c.(328-330)taC>taT	p.Y110Y	KCNC4_uc001dzf.3_Silent_p.Y110Y|KCNC4_uc001dzh.3_Silent_p.Y110Y|KCNC4_uc001dzi.3_Non-coding_Transcript|KCNC4_uc001dzg.3_Silent_p.Y110Y	NM_001039574	NP_001034663	Q03721	KCNC4_HUMAN	Homo sapiens potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), transcript variant 3, mRNA.	110					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCAACTACTACCGCACCGGCA	0.677000													23	26					0	0	1	0	0
AL117485	0	broad.mit.edu	37	22	18846025	18846025	+	RNA	SNP	G	G	C	rs5993363		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr22:18846025G>C	uc002zoe.3	+	4		c.2387G>C			AL117485_uc002zof.3_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		GACGTTGAAGGCTGCCTTCAG	0.647000													4	73					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75439191	75439191	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:75439191T>C	uc010rru.2	+	4	650	c.650_splice	c.e4+2	p.G217_splice	MOGAT2_uc001oww.1_Missense_Mutation_p.Y218H|MOGAT2_uc010rrv.2_Splice_Site_p.G135_splice	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	Homo sapiens monoacylglycerol O-acyltransferase 2 (MOGAT2), mRNA.	217					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					GACACACGGGTATCAAGCCTC	0.547000													15	3					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	58289244	58289244	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:58289244G>C	uc003jsa.2	-	6	1142	c.970C>G	c.(970-972)Cgg>Ggg	p.R324G	PDE4D_uc003jrx.2_Missense_Mutation_p.R188G|PDE4D_uc003jry.3_Missense_Mutation_p.R22G|PDE4D_uc003jrz.3_Missense_Mutation_p.R260G|PDE4D_uc003jsb.3_Missense_Mutation_p.R263G|PDE4D_uc003jrt.2_Missense_Mutation_p.R22G|PDE4D_uc003jru.3_Missense_Mutation_p.R100G|PDE4D_uc003jrv.2_Missense_Mutation_p.R194G|PDE4D_uc003jrw.2_Missense_Mutation_p.R202G|PDE4D_uc010iwi.1_3'UTR|PDE4D_uc003jrs.2_Missense_Mutation_p.R33G	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	Homo sapiens phosphodiesterase 4D, cAMP-specific (PDE4D), transcript variant 1, mRNA.	324					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TTTCCAGACCGACTCATTTCA	0.318000													10	16					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344949	20344949	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr14:20344949G>T	uc001vwh.1	+	0	523	c.523G>T	c.(523-525)Gac>Tac	p.D175Y		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily K, member 2 (OR4K2), mRNA.	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTATGAGGTAGACAGCTTTTT	0.458000													124	229					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577569	7577569	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:7577569A>G	uc002gim.2	-	6	906	c.712T>C	c.(712-714)Tgt>Cgt	p.C238R	TP53_uc002gig.1_Missense_Mutation_p.C238R|TP53_uc002gih.3_Missense_Mutation_p.C238R|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Missense_Mutation_p.C106R|TP53_uc010cnf.1_Missense_Mutation_p.C106R|TP53_uc002gii.1_Missense_Mutation_p.C106R|TP53_uc010cni.1_Missense_Mutation_p.C238R|TP53_uc010cnh.1_Missense_Mutation_p.C238R|TP53_uc002gij.2_Missense_Mutation_p.C238R|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_Missense_Mutation_p.C145R|TP53_uc002gio.2_Missense_Mutation_p.C106R|DL476309_uc021tpg.1_Non-coding_Transcript|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	238	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(109)|p.C238Y(57)|p.C238F(36)|p.C238S(31)|p.C238R(28)|p.M237K(9)|p.0?(8)|p.M237_N239delMCN(6)|p.C238G(6)|p.M237V(6)|p.?(5)|p.C238*(4)|p.M237fs*10(4)|p.C238del(3)|p.M237R(3)|p.M237L(3)|p.Y236_M243delYMCNSSCM(2)|p.C238fs*2(2)|p.M237_C238insX(2)|p.C238fs*9(2)|p.C238_M246delCNSSCMGGM(2)|p.C238W(2)|p.C238fs*21(2)|p.M237fs*1(2)|p.H233_C242del10(2)|p.M237T(2)|p.C238_N239insX(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.M144_N146delMCN(1)|p.C238C(1)|p.Y236_M237delYM(1)|p.C145G(1)|p.Y236_M237insXX(1)|p.H233fs*6(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAACTGTTACACATGTAGTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	6					0	0	1	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33122480	33122480	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:33122480C>T	uc002xal.3	+	2	188	c.128C>T	c.(127-129)gCc>gTc	p.A43V	DYNLRB1_uc010zuk.2_Missense_Mutation_p.A43V	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Homo sapiens dynein, light chain, roadblock-type 1 (DYNLRB1), mRNA.	43					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity			endometrium(1)|large_intestine(1)|lung(1)	3						ACCCAGTATGCCAGCCTCATG	0.572000													4	119					0	0	1	0	0
CHST10	9486	broad.mit.edu	37	2	101011979	101011979	+	Silent	SNP	A	A	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:101011979A>G	uc002tam.3	-	5	923	c.525T>C	c.(523-525)atT>atC	p.I175I		NM_004854	NP_004845	O43529	CHSTA_HUMAN	Homo sapiens carbohydrate sulfotransferase 10 (CHST10), mRNA.	175					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						ACCGCTTCTGAATTTCTGCAT	0.507000													18	35					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134671235	134671235	+	Silent	SNP	C	C	T	rs146998210	by1000genomes	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr10:134671235C>T	uc021qbc.1	-	38	5534	c.5433G>A	c.(5431-5433)gcG>gcA	p.A1811A		NM_001200049	NP_001186978	Q8IYW2	CJ092_HUMAN	Homo sapiens tetratricopeptide repeat domain 40 (TTC40), mRNA.	476								p.A1811A(2)		breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						CCAGGCCATACGCTTCCAAGT	0.473000													16	13					0	0	1	0	0
FGF10	2255	broad.mit.edu	37	5	44305205	44305205	+	Silent	SNP	C	C	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:44305205C>A	uc003jog.1	-	2	519	c.519G>T	c.(517-519)ggG>ggT	p.G173G		NM_004465	NP_004456	O15520	FGF10_HUMAN	Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.	173					ERK1 and ERK2 cascade|actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of Ras protein signal transduction|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					ACATTTGCCTCCCATTATGCT	0.413000													30	130					0	0	1	0	0
OR2C1	4993	broad.mit.edu	37	16	3406726	3406726	+	Silent	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr16:3406726G>A	uc002cuw.1	+	0	838	c.786G>A	c.(784-786)ccG>ccA	p.P262P		NM_012368	NP_036500	O95371	OR2C1_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily C, member 1 (OR2C1), mRNA.	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						ATCTGCTTCCGGCCAAGAACA	0.552000													15	38					0	0	1	0	0
MBD1	4152	broad.mit.edu	37	18	47799975	47799975	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr18:47799975C>G	uc002lem.4	-	11	1842	c.1405G>C	c.(1405-1407)Gtg>Ctg	p.V469L	MBD1_uc002lef.3_Missense_Mutation_p.V220L|MBD1_uc002leg.3_Missense_Mutation_p.V419L|MBD1_uc010dow.2_Missense_Mutation_p.V469L|MBD1_uc010xdi.2_Missense_Mutation_p.V520L|MBD1_uc010xdj.2_Missense_Mutation_p.V413L|MBD1_uc002lel.4_Missense_Mutation_p.V446L|MBD1_uc002len.3_Missense_Mutation_p.V469L|MBD1_uc002leh.4_Missense_Mutation_p.V413L|MBD1_uc002lei.4_Missense_Mutation_p.V469L|MBD1_uc002lej.4_Missense_Mutation_p.V413L|MBD1_uc002lek.4_Missense_Mutation_p.V420L|MBD1_uc021ukd.1_Missense_Mutation_p.V493L|MBD1_uc021uke.1_Missense_Mutation_p.V438L|MBD1_uc010xdk.2_Missense_Mutation_p.V494L|MBD1_uc010dox.1_Missense_Mutation_p.V446L|MBD1_uc002leo.2_Missense_Mutation_p.V469L	NM_001204136	NP_001191065	Q9UIS9	MBD1_HUMAN	Homo sapiens methyl-CpG binding domain protein 1 (MBD1), transcript variant 6, mRNA.	469					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						GGGCCCGGCACCTGCACAGGA	0.642000													21	20					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182597349	182597349	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:182597349T>G	uc003flb.3	+	19	2575	c.2318T>G	c.(2317-2319)cTc>cGc	p.L773R	ATP11B_uc003flc.3_Missense_Mutation_p.L357R|ATP11B_uc011bqm.1_Missense_Mutation_p.L77R|ATP11B_uc010hxf.1_5'UTR	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	Homo sapiens ATPase, class VI, type 11B (ATP11B), mRNA.	773					ATP biosynthetic process|aminophospholipid transport	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TCTCTTGCACTCAGGGAGCAT	0.378000													45	24					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154360937	154360937	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr6:154360937C>T	uc011efe.2	+	2	1060	c.537C>T	c.(535-537)ttC>ttT	p.F179F	OPRM1_uc011efb.2_Silent_p.F134F|OPRM1_uc011efd.2_Intron|OPRM1_uc011efc.1_Intron|OPRM1_uc003qpn.2_Silent_p.F86F|OPRM1_uc003qpo.1_Silent_p.F86F|OPRM1_uc011eff.1_Silent_p.F86F|OPRM1_uc011efg.1_Silent_p.F86F|OPRM1_uc011efi.2_Silent_p.F86F|OPRM1_uc011efh.1_Silent_p.F86F|OPRM1_uc003qpq.1_Silent_p.F86F|OPRM1_uc003qpr.2_Silent_p.F86F|OPRM1_uc003qpt.1_Silent_p.F86F|OPRM1_uc003qpp.2_Non-coding_Transcript|OPRM1_uc003qps.2_Non-coding_Transcript	NM_001145279	NP_001138751	P35372	OPRM_HUMAN	Homo sapiens opioid receptor, mu 1 (OPRM1), transcript variant MOR-1H, mRNA.	86					behavior|negative regulation of cell proliferation|sensory perception	Golgi apparatus|endoplasmic reticulum|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TGGGGCTCTTCGGAAACTTCC	0.592000													21	52					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86302260	86302260	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:86302260C>T	uc002sqs.3	-	11	1883	c.1504G>A	c.(1504-1506)Ggc>Agc	p.G502S		NM_015425	NP_056240	O95602	RPA1_HUMAN	Homo sapiens polymerase (RNA) I polypeptide A, 194kDa (POLR1A), mRNA.	502					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GTGCGGCTGCCGTCCTCATTG	0.627000													12	7					0	0	1	0	0
BC080605	0	broad.mit.edu	37	9	68413573	68413573	+	RNA	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr9:68413573G>A	uc004aex.3	+	0		c.128G>A								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CAGTGGCGCCGGATCTAGGAA	0.597000													5	16					0	0	1	0	0
MFSD3	113655	broad.mit.edu	37	8	145735980	145735980	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:145735980G>A	uc003zdi.1	+	3	996	c.831_splice	c.e3-1	p.W277_splice		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	Homo sapiens major facilitator superfamily domain containing 3 (MFSD3), mRNA.	277	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCCCATCCCAGGAAACTGCTG	0.637000													164	158					0	0	1	0	0
FLJ43315	644316	broad.mit.edu	37	GL000211.1	107044	107044	+	RNA	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chrGL000211.1:107044T>C	uc003boa.3	+	3		c.743T>C								Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding RNA.																		ACAAAGAAAATAGAACGCCTT	0.358000													6	123					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233346218	233346218	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:233346218G>A	uc002vsv.2	-	13	2192	c.1987C>T	c.(1987-1989)Cgg>Tgg	p.R663W	ECEL1_uc010fya.1_Missense_Mutation_p.R661W|ECEL1_uc010fyb.1_Missense_Mutation_p.R370W	NM_004826	NP_004817	O95672	ECEL1_HUMAN	Homo sapiens endothelin converting enzyme-like 1 (ECEL1), mRNA.	663					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTCTCACCCGCTGGTTGTAG	0.622000													10	15					0	0	1	0	0
CEP41	95681	broad.mit.edu	37	7	130080807	130080807	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:130080807T>C	uc003vpz.3	-	0	48	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	CEP41_uc010lmf.3_5'UTR|CEP41_uc003vqa.3_Missense_Mutation_p.M1V|CEP41_uc011kpg.2_Missense_Mutation_p.M1V|CEP41_uc003vqb.1_Non-coding_Transcript	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	Homo sapiens centrosomal protein 41kDa (CEP41), mRNA.	1					G2/M transition of mitotic cell cycle	centrosome|cytosol											CGGAGGGACATATTTTCTCCA	0.632000													17	32					0	0	1	0	0
UQCRC1	7384	broad.mit.edu	37	3	48646687	48646687	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:48646687G>C	uc003cub.1	-	1	163	c.118C>G	c.(118-120)Cag>Gag	p.Q40E		NM_003365	NP_003356	P31930	QCR1_HUMAN	Homo sapiens ubiquinol-cytochrome c reductase core protein I (UQCRC1), mRNA.	40					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	TGGAGCGCCTGAGCGAAGGTT	0.667000													35	1					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135012115	135012115	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:135012115C>T	uc002ttw.4	+	0	286	c.141C>T	c.(139-141)cgC>cgT	p.R47R		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5), mRNA.	47					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CCATGCTGCGCGAGCAGATCC	0.512000													19	39					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140174613	140174613	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:140174613G>A	uc003lhd.2	+	0	170	c.64G>A	c.(64-66)Gca>Aca	p.A22T	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhc.1_Missense_Mutation_p.A22T|PCDHAC2_uc011czy.2_Missense_Mutation_p.A22T	NM_018905	NP_061728	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 2 (PCDHA2), transcript variant 1, mRNA.	35					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCTCCTCGCAGCCTGGGA	0.622000													30	30					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929145	4929145	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:4929145G>C	uc010qyq.2	+	0	546	c.546G>C	c.(544-546)caG>caC	p.Q182H		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily A, member 7 (OR51A7), mRNA.	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H181N(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCTTCATCAGGATACCATGA	0.403000													21	41					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23345059	23345059	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr14:23345059C>G	uc001whd.3	+	4	1455	c.902C>G	c.(901-903)aCc>aGc	p.T301S	LRP10_uc001whe.3_Missense_Mutation_p.T177S	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 10 (LRP10), mRNA.	301	CUB 2.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TTCAATGCCACCTACCATGTG	0.582000													24	39					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129853995	129853995	+	Silent	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr9:129853995G>A	uc004bqr.1	-	3	1736	c.1236C>T	c.(1234-1236)aaC>aaT	p.N412N	RALGPS1_uc022bno.1_Intron|RALGPS1_uc011mab.2_Intron|RALGPS1_uc011mac.2_Intron|RALGPS1_uc004bqo.2_Intron|RALGPS1_uc004bqq.4_Intron|ANGPTL2_uc010mxg.1_Silent_p.N110N	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	Homo sapiens angiopoietin-like 2 (ANGPTL2), mRNA.	412	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						ACTGCTTGCCGTTGTGCCATG	0.537000													99	94					0	0	1	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958846	57958846	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:57958846A>G	uc010rka.2	+	0	941	c.884A>G	c.(883-885)aAg>aGg	p.K295R		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	Homo sapiens olfactory receptor, family 9, subfamily Q, member 2 (OR9Q2), mRNA.	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(24)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41		Breast(21;0.0589)				CTGAGAAACAAGGAGGTAAAA	0.498000													32	49					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173907982	173907982	+	Silent	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:173907982T>C	uc010pmt.2	-	18	3369	c.3282A>G	c.(3280-3282)acA>acG	p.T1094T	RC3H1_uc001gju.4_Silent_p.T1093T|RC3H1_uc010pms.2_Silent_p.T1084T|RC3H1_uc001gjv.3_Silent_p.T1085T	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	Homo sapiens ring finger and CCCH-type domains 1 (RC3H1), mRNA.	1093					cytoplasmic mRNA processing body assembly|negative regulation of B cell proliferation|negative regulation of T-helper cell differentiation|negative regulation of activated T cell proliferation|negative regulation of germinal center formation|nuclear-transcribed mRNA catabolic process|regulation of T cell receptor signaling pathway|regulation of mRNA stability	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TATTCTCTTGTGTCAAGGCTG	0.413000													17	19					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9343593	9343593	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:9343593C>T	uc021wam.1	+	4	435	c.420C>T	c.(418-420)aaC>aaT	p.N140N	PLCB4_uc010gbw.1_Silent_p.N140N|PLCB4_uc010gbx.3_Silent_p.N140N|PLCB4_uc021wal.1_Silent_p.N140N	NM_000933	NP_000924	Q15147	PLCB4_HUMAN	Homo sapiens phospholipase C, beta 4 (PLCB4), transcript variant 1, mRNA.	140					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GGGCCAACAACGTCAGTCCAA	0.413000													8	7					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87912423	87912423	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:87912423G>A	uc022agz.1	-	3	740	c.517C>T	c.(517-519)Ctt>Ttt	p.L173F	STEAP4_uc003ujs.3_Missense_Mutation_p.L173F|STEAP4_uc010lek.3_Intron	NM_001205315	NP_001192244	Q687X5	STEA4_HUMAN	Homo sapiens STEAP family member 4 (STEAP4), transcript variant 2, mRNA.	173					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					GTAAGTCCAAGATTACGAACA	0.388000													18	20					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58965695	58965695	+	Silent	SNP	C	C	T	rs148369158	by1000genomes	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:58965695C>T	uc002qsv.1	+	2	329	c.222C>T	c.(220-222)taC>taT	p.Y74Y	ZNF324B_uc002qsu.1_5'UTR|ZNF324B_uc010euq.1_Silent_p.Y74Y	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	Homo sapiens zinc finger protein 324B (ZNF324B), mRNA.	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GGAACACCTACGGGAGGCTCA	0.577000													18	55					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32712485	32712485	+	Silent	SNP	A	A	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:32712485A>C	uc003jhv.3	+	0	1048	c.603A>C	c.(601-603)gcA>gcC	p.A201A	NPR3_uc010iuo.3_Intron|NPR3_uc003jhw.2_Intron|NPR3_uc003jhu.3_Silent_p.A201A	NM_001204375	NP_001191304	P17342	ANPRC_HUMAN	Homo sapiens natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (NPR3), transcript variant 1, mRNA.	201					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	GCCGCGCTGCACTGGTCTACA	0.632000													26	133					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183600828	183600828	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:183600828G>A	uc003ivd.1	+	6	1411	c.1336G>A	c.(1336-1338)Gtg>Atg	p.V446M	ODZ3_uc003ive.1_5'Flank	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	Homo sapiens odz, odd Oz/ten-m homolog 3 (Drosophila) (ODZ3), mRNA.	446					signal transduction	integral to membrane				NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(35)|lung(56)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(4)	129		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GTATGACTTCGTGGAGCTCCT	0.532000													12	27					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904194	21904194	+	RNA	SNP	C	C	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:21904194C>A	uc002gza.2	+	0		c.133C>A								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		agcctcaggcctgccaggacg	0.677000													4	95					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64167232	64167232	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:64167232G>A	uc003ttd.3	+	6	1336	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	ZNF107_uc003tte.3_Missense_Mutation_p.E184K	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	Homo sapiens zinc finger protein 107 (ZNF107), transcript variant 1, mRNA.	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AATTCATACTGAAGAGAAACC	0.368000													11	21					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122726442	122726442	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr11:122726442G>A	uc001pyj.3	+	4	530	c.530G>A	c.(529-531)tGt>tAt	p.C177Y		NM_019604	NP_062550	O95727	CRTAM_HUMAN	Homo sapiens cytotoxic and regulatory T cell molecule (CRTAM), mRNA.	177	Ig-like C2-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding	p.C177*(1)		breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GGGAAGAAATGTAATACTACC	0.413000													16	25					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192227005	192227005	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:192227005C>G	uc010fsg.2	+	8	928	c.673C>G	c.(673-675)Ctt>Gtt	p.L225V	MYO1B_uc002usq.2_Missense_Mutation_p.L225V|MYO1B_uc002usr.2_Missense_Mutation_p.L225V|MYO1B_uc002uss.1_Missense_Mutation_p.L225V	NM_001130158	NP_001155291	O43795	MYO1B_HUMAN	Homo sapiens myosin IB (MYO1B), transcript variant 1, mRNA.	225	Myosin head-like.					myosin complex	ATP binding|actin binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TAAACTTAAGCTTGAGAGGGA	0.383000													19	25					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228511259	228511259	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:228511259G>A	uc009xez.1	+	55	15648	c.15604G>A	c.(15604-15606)Gag>Aag	p.E5202K	OBSCN_uc001hsn.3_Missense_Mutation_p.E5202K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	5202	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding	p.P5202P(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGCCTGGCCGAGAACAGCAT	0.582000													21	22					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105543428	105543428	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr12:105543428C>T	uc010swr.2	+	24	2640	c.2553C>T	c.(2551-2553)ttC>ttT	p.F851F	KIAA1033_uc001tld.3_Silent_p.F850F|KIAA1033_uc010sws.2_Silent_p.F662F	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	Homo sapiens KIAA1033 (KIAA1033), mRNA.	850					endosome transport	WASH complex		p.F850L(2)		breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						AAAAGAAGTTCTATATATTTA	0.234000													21	24					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98429149	98429149	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:98429149C>G	uc002syh.4	-	15	1910	c.1681G>C	c.(1681-1683)Gaa>Caa	p.E561Q		NM_015348	NP_056163	Q92545	TM131_HUMAN	Homo sapiens transmembrane protein 131 (TMEM131), mRNA.	561						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TTACTTGCTTCTGTAGCACTC	0.308000													10	18					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56434921	56434921	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:56434921G>A	uc002iwf.3	-	7	4172	c.2216C>T	c.(2215-2217)cCa>cTa	p.P739L	RNF43_uc010wnv.2_Missense_Mutation_p.P698L|RNF43_uc002iwh.4_Missense_Mutation_p.P739L|RNF43_uc002iwg.4_Missense_Mutation_p.P739L|RNF43_uc010dcw.3_Missense_Mutation_p.P612L	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	Homo sapiens ring finger protein 43 (RNF43), mRNA.	739	Pro-rich.					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCCCCAGGTGGATGTGGTTC	0.607000													44	83					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940592	144940592	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:144940592C>T	uc003zaa.1	-	0	6843	c.6830G>A	c.(6829-6831)cGc>cAc	p.R2277H		NM_031308	NP_112598	P58107	EPIPL_HUMAN	Homo sapiens epiplakin 1 (EPPK1), mRNA.	2277						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTCAGGTTGCGCACGGGGTC	0.726000													13	263					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19018402	19018402	+	Silent	SNP	C	C	T	rs148641282	by1000genomes	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr1:19018402C>T	uc001bay.3	+	4	1339	c.741C>T	c.(739-741)cgC>cgT	p.R247R	PAX7_uc001baz.3_Silent_p.R245R|PAX7_uc010oct.2_Silent_p.R247R	NM_002584	NP_002575	P23759	PAX7_HUMAN	Homo sapiens paired box 7 (PAX7), transcript variant 1, mRNA.	247					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R247L(1)	PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TATACACCCGCGAGGAGCTGG	0.607000			T	FOXO1A	alveolar rhabdomyosarcoma								13	20					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56270402	56270402	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr8:56270402T>G	uc003xsf.3	+	1	1003	c.971T>G	c.(970-972)aTt>aGt	p.I324S		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	Homo sapiens XK, Kell blood group complex subunit-related family, member 4 (XKR4), mRNA.	324						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTCTGCATTATCGTACAG	0.453000													12	76					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173355990	173355990	+	Silent	SNP	G	G	A	rs34599583	byFrequency	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:173355990G>A	uc002uhp.1	+	21	3023	c.2820G>A	c.(2818-2820)ccG>ccA	p.P940P	ITGA6_uc010zdy.1_Silent_p.P821P|ITGA6_uc002uho.1_Silent_p.P940P|ITGA6_uc010fqm.1_Silent_p.P571P	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	Homo sapiens integrin, alpha 6 (ITGA6), transcript variant 1, mRNA.	979					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TCAGATGCCCGCTGCGGGGGC	0.483000													44	100					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25277119	25277119	+	Silent	SNP	C	C	T	rs141315124	byFrequency	TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr20:25277119C>T	uc002wup.3	+	19	2602	c.2493C>T	c.(2491-2493)tcC>tcT	p.S831S	ABHD12_uc002wuq.3_Intron	NM_002862	NP_002853	P11216	PYGB_HUMAN	Homo sapiens phosphorylase, glycogen; brain (PYGB), mRNA.	831					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	TGGAGCCCTCCGACCTGCAGA	0.612000													39	34					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119237434	119237434	+	Missense_Mutation	SNP	G	G	C	rs139059047		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:119237434G>C	uc003ica.2	-	5	1242	c.1195C>G	c.(1195-1197)Cgc>Ggc	p.R399G		NM_003619	NP_003610	P56730	NETR_HUMAN	Homo sapiens protease, serine, 12 (neurotrypsin, motopsin) (PRSS12), mRNA.	399	SRCR 3.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						ACCTCCAAGCGACCCTCATGG	0.458000													14	23					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215876784	215876784	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:215876784T>G	uc002vew.3	-	15	2252	c.2032A>C	c.(2032-2034)Aat>Cat	p.N678H	ABCA12_uc002vev.3_Missense_Mutation_p.N360H|ABCA12_uc010zjn.2_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 12 (ABCA12), transcript variant 1, mRNA.	678					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCCATCTGATTGAGAATCTCT	0.403000													28	79					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35157400	35157400	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr7:35157400G>A	uc003teq.1	-	15	1774	c.667C>T	c.(667-669)Cgt>Tgt	p.R223C	DPY19L2P1_uc003tep.1_Non-coding_Transcript|DPY19L2P1_uc010kwz.1_Non-coding_Transcript					Homo sapiens dpy-19-like 2 pseudogene 1 (C. elegans) (DPY19L2P1), non-coding RNA.																		GAAATATCACGAACAGTCTGT	0.264000													4	3					0	0	1	0	0
TMEM97	27346	broad.mit.edu	37	17	26652535	26652535	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:26652535A>C	uc002hat.3	+	1	278	c.133A>C	c.(133-135)Aac>Cac	p.N45H		NM_014573	NP_055388	Q5BJF2	TMM97_HUMAN	Homo sapiens transmembrane protein 97 (TMEM97), mRNA.	45					cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding			endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	6	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TCAGTTTAGAAACCTGCTGAA	0.468000													53	27					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57972082	57972082	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr12:57972082T>G	uc001sor.1	+	22	2703	c.2495T>G	c.(2494-2496)tTt>tGt	p.F832C	KIF5A_uc010srr.1_Missense_Mutation_p.F743C	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	Homo sapiens kinesin family member 5A (KIF5A), mRNA.	832					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity	p.S831S(1)		breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						AAGATTTCCTTTCTTGAGAAC	0.478000													41	113					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229382	8229382	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr4:8229382G>C	uc003gkv.4	+	11	2062	c.1961G>C	c.(1960-1962)cGg>cCg	p.R654P	SH3TC1_uc003gkw.4_Missense_Mutation_p.R578P|SH3TC1_uc003gkx.4_Non-coding_Transcript|SH3TC1_uc003gky.3_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	Homo sapiens SH3 domain and tetratricopeptide repeats 1 (SH3TC1), mRNA.	654							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GCGCTGCGGCGGGCGGTGGGT	0.726000													19	15					0	0	1	0	0
TRADD	8717	broad.mit.edu	37	16	67189313	67189313	+	Silent	SNP	C	C	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr16:67189313C>T	uc002eri.1	-	2	476	c.396G>A	c.(394-396)gaG>gaA	p.E132E	TRADD_uc002erh.1_Silent_p.E72E	NM_003789	NP_003780	Q15628	TRADD_HUMAN	Homo sapiens TNFRSF1A-associated via death domain (TRADD), mRNA.	132					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		AACAGCGCTCCTCGTCCGCCA	0.711000													19	1					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	106926482	106926482	+	RNA	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr14:106926482T>C	uc021ser.1	-	325		c.11386A>G								Parts of antibodies, mostly variable regions.																		CCAGCTGCACTTCACACTGGA	0.527000													4	176					0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49445979	49445979	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr12:49445979G>A	uc001rta.4	-	9	1487	c.1487C>T	c.(1486-1488)cCg>cTg	p.P496L		NM_003482	NP_003473	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2), mRNA.	496	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						CTCAGGCGGCGGAGAGAGGGG	0.617000			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)			20	78					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342516	40342516	+	Silent	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:40342516G>A	uc002rrx.3	-	9	2823	c.2799C>T	c.(2797-2799)atC>atT	p.I933I	LOC100128590_uc002rrw.3_Intron|SLC8A1_uc002rry.3_Silent_p.I928I|SLC8A1_uc002rsb.2_Silent_p.I925I|SLC8A1_uc002rrz.3_Silent_p.I920I|SLC8A1_uc002rsa.3_Silent_p.I897I|SLC8A1_uc002rsd.4_Silent_p.I897I	NM_021097	NP_066920	P32418	NAC1_HUMAN	Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A, mRNA.	933					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTCACCTCCGATTTCTGGCC	0.547000													21	49					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5485302	5485302	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr17:5485302G>C	uc002gci.3	-	2	1084	c.529C>G	c.(529-531)Ccc>Gcc	p.P177A	NLRP1_uc002gcg.1_Missense_Mutation_p.P177A|NLRP1_uc002gch.4_Missense_Mutation_p.P177A|NLRP1_uc002gck.3_Missense_Mutation_p.P177A|NLRP1_uc002gcj.3_Missense_Mutation_p.P177A|NLRP1_uc002gcl.3_Missense_Mutation_p.P177A|NLRP1_uc010clh.3_Missense_Mutation_p.P177A	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	Homo sapiens NLR family, pyrin domain containing 1 (NLRP1), transcript variant 1, mRNA.	177					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	NALP1 inflammasome complex|cytoplasm|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GTGGATGTGGGGGCGTTGGGT	0.597000													18	24					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23908318	23908318	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr13:23908318T>C	uc001uon.2	-	9	10286	c.9697A>G	c.(9697-9699)Aag>Gag	p.K3233E	SACS_uc001uoo.2_Missense_Mutation_p.K3086E|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	Homo sapiens spastic ataxia of Charlevoix-Saguenay (sacsin) (SACS), mRNA.	3233					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|Hsp70 protein binding|chaperone binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCTTTCCACTTTGTGCAACTT	0.358000													22	40					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128350403	128350403	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr2:128350403G>A	uc002top.3	+	16	2080	c.2027G>A	c.(2026-2028)cGa>cAa	p.R676Q		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	Homo sapiens myosin VIIB (MYO7B), mRNA.	676	Myosin head-like.					apical plasma membrane|myosin complex	ATP binding|actin binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGGCAGCTGCGATACTCGGGC	0.667000													5	14					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48681080	48681081	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr3:48681080_48681081delCA	uc003cuf.1	-	29	8489_8490	c.8489_8490delTG	c.(8488-8490)ctgfs	p.L2830fs	CELSR3_uc010hkf.3_Frame_Shift_Del_p.L22fs|CELSR3_uc010hkg.3_Frame_Shift_Del_p.L715fs|CELSR3_uc003cul.3_Frame_Shift_Del_p.L2732fs	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) (CELSR3), mRNA.	2732					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|calcium ion binding|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACTGACCAGCAGAAGCAGCAG	0.599													2	4	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127670459	127670459	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr5:127670459delG	uc003kuu.3	-	30	4490	c.4051delC	c.(4051-4053)cacfs	p.H1351fs	FBN2_uc003kuv.2_Frame_Shift_Del_p.H1318fs	NM_001999	NP_001990	P35556	FBN2_HUMAN	Homo sapiens fibrillin 2 (FBN2), mRNA.	1351	EGF-like 21; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGCTGACAGTGGCAAATGAAG	0.398													26	32	---	---	---	---					
HIST1H2BJ	8970	broad.mit.edu	37	6	27100294	27100295	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr6:27100294_27100295insT	uc003niv.3	-	0	281_282	c.235_236insA	c.(235-237)tccfs	p.S79fs	HIST1H2BJ_uc003niu.1_Intron|HIST1H2AG_uc003niw.3_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	Homo sapiens histone cluster 1, H2bj (HIST1H2BJ), mRNA.	79					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						CGCCAGGCGGGAAGCCTCACCT	0.604													118	76	---	---	---	---					
LOC100131094	100131094	broad.mit.edu	37	19	4682879	4682880	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:4682879_4682880delAG	uc021ung.1	+	1	325_326	c.9_10delAG	c.(7-12)gcagagfs	p.A3fs	DPP9_uc002mba.3_Intron	NM_001242901	NP_001229830			Homo sapiens uncharacterized LOC100131094 (LOC100131094), mRNA.																		AGATGGGGGCAGAGAGAGAGAG	0.663													3	5	---	---	---	---					
ARHGAP35	2909	broad.mit.edu	37	19	47491244	47491249	+	Splice_Site	DEL	AGGACT	AGGACT	-			TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:47491244_47491249delAGGACT	uc010ekv.3	+	3	3827	c.3827_splice	c.e3-1	p.G1276_splice		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	Homo sapiens Rho GTPase activating protein 35 (ARHGAP35), mRNA.	1276	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity	p.G1276V(4)|p.?(2)									GTTTCTCCTCAGGACTGAGCACGGAA	0.558													15	9	---	---	---	---					
BC034929	0	broad.mit.edu	37	19	55703327	55703329	+	In_Frame_Del	DEL	CCT	CCT	-	rs10545294		TCGA-N7-A4Y5-01A-12D-A28R-08	TCGA-N7-A4Y5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42067f30-2429-4387-b816-990afa9365e3	ae33ea51-4262-478c-b4d9-1eb469541715	g.chr19:55703327_55703329delCCT	uc002qjr.3	+	1	429_431	c.411_413delCCT	c.(409-414)tacctc>tac	p.L142del	PTPRH_uc010esv.3_Intron|PTPRH_uc002qjq.3_Intron					Homo sapiens, clone IMAGE:4553293, mRNA.																		ccctctcctacctcctcctcctc	0.488													3	4	---	---	---	---					
