Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LRP3	4037	broad.mit.edu	37	19	33687683	33687683	+	Splice_Site	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:33687683G>C	uc010edh.3	+	2	214	c.121_splice	c.e2+1	p.A41_splice	LRP3_uc010xrp.1_Splice_Site	NM_002333	NP_002324	O75074	LRP3_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 3 (LRP3), mRNA.	41					receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					TCCTGCCTTAGGTAAGTAAGC	0.552000													35	55					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39660328	39660328	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:39660328G>C	uc002okj.1	+	3	596	c.135G>C	c.(133-135)gaG>gaC	p.E45D	PAK4_uc002okl.1_Missense_Mutation_p.E45D|PAK4_uc002okn.1_Missense_Mutation_p.E45D|PAK4_uc002okm.1_Missense_Mutation_p.E45D|PAK4_uc002oko.1_Missense_Mutation_p.E45D|PAK4_uc002okp.1_Missense_Mutation_p.E45D	NM_001014831	NP_005875	O96013	PAK4_HUMAN	Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4), transcript variant 2, mRNA.	45	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			TGATCGAGGAGTCGGCTCGCC	0.706000													28	9					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376865	18376865	+	Silent	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:18376865G>C	uc010ebn.2	-	2	1701	c.1485C>G	c.(1483-1485)acC>acG	p.T495T	KIAA1683_uc002nin.2_Silent_p.T495T|KIAA1683_uc010xqe.1_Silent_p.T449T	NM_001145304	NP_001138776	Q9H0B3	K1683_HUMAN	Homo sapiens KIAA1683 (KIAA1683), transcript variant 1, mRNA.	495						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTGGCAGGCGGGTCTGGGGTG	0.572000													100	56					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47060923	47060923	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:47060923T>C	uc004dhj.4	+	7	876	c.725T>C	c.(724-726)tTt>tCt	p.F242S	UBA1_uc004dhk.4_Missense_Mutation_p.F242S	NM_153280	NP_695012	P22314	UBA1_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 1 (UBA1), transcript variant 2, mRNA.	242	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CGACACGGGTTTGAGAGCGGG	0.547000													11	31					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28610154	28610154	+	Splice_Site	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:28610154G>C	uc003szq.3	+	5	854	c.464_splice	c.e5+1	p.G155_splice	CREB5_uc003szo.3_Splice_Site_p.G122_splice|CREB5_uc003szr.3_Splice_Site_p.G148_splice	NM_182898	NP_878902	Q02930	CREB5_HUMAN	Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript variant 1, mRNA.	155					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CCGCCAGATCGGGTAAGGAGC	0.572000													40	22					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141756660	141756660	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:141756660C>T	uc003vwy.3	+	29	3665	c.3611C>T	c.(3610-3612)aCa>aTa	p.T1204I		NM_004668	NP_004659	O43451	MGA_HUMAN	Homo sapiens maltase-glucoamylase (alpha-glucosidase) (MGAM), mRNA.	1204	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGCCTTGACATACCGCACC	0.517000													9	28					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76045946	76045946	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:76045946G>A	uc002jud.2	+	3	1403	c.803G>A	c.(802-804)gGg>gAg	p.G268E	TNRC6C_uc002juf.2_Missense_Mutation_p.G268E|TNRC6C_uc002jue.2_Missense_Mutation_p.G268E	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	Homo sapiens trinucleotide repeat containing 6C (TNRC6C), transcript variant 2, mRNA.	268	Gly-rich.|Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		RNA binding|nucleotide binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTCAGTCAGGGGAATGGAGAC	0.493000													30	115					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80660253	80660253	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr12:80660253G>A	uc001szd.3	+	19	2226	c.2220G>A	c.(2218-2220)atG>atA	p.M740I		NM_173591	NP_775862			Homo sapiens otogelin-like (OTOGL), mRNA.											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGAAGGGCATGCTGTACCATC	0.483000													4	22					0	0	1	0	0
BC012753	0	broad.mit.edu	37	GL000214.1	30761	30761	+	RNA	SNP	G	G	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrGL000214.1:30761G>T	uc011mfm.2	+	0		c.381G>T								Homo sapiens cDNA clone IMAGE:3625232, partial cds.																		ATGTGTCCCGGTGCTAACACA	0.572000													3	5					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31381340	31381340	+	Splice_Site	SNP	A	A	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr20:31381340A>G	uc002wyc.3	+	10	1388	c.1067_splice	c.e10-2	p.V356_splice	DNMT3B_uc010ztx.1_Intron|DNMT3B_uc010zty.1_Intron|DNMT3B_uc002wyd.3_Intron|DNMT3B_uc002wye.3_Intron|DNMT3B_uc010ztz.2_Intron|DNMT3B_uc010zua.2_Intron|DNMT3B_uc010gee.3_Intron|DNMT3B_uc010gef.3_Intron|DNMT3B_uc002wyf.3_Intron|DNMT3B_uc002wyg.3_Splice_Site_p.V55_splice	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	Homo sapiens DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B), transcript variant 1, mRNA.	356					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						tcccctcaaaagtggttaata	0.388000													14	21					0	0	1	0	0
RS1	6247	broad.mit.edu	37	X	18660259	18660259	+	Silent	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:18660259C>T	uc004cyo.3	-	5	575	c.540G>A	c.(538-540)tcG>tcA	p.S180S	CDKL5_uc004cym.3_Intron|CDKL5_uc004cyn.3_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	Homo sapiens retinoschisin 1 (RS1), mRNA.	180	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					AGGTGCGGTCCGAGTTGCCAT	0.587000													48	40					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26448652	26448652	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:26448652A>G	uc003nhz.3	+	5	1135	c.892A>G	c.(892-894)Aca>Gca	p.T298A	BTN3A3_uc011dkn.2_Missense_Mutation_p.T256A|BTN3A3_uc021ynh.1_Intron	NM_006994	NP_008925	O00478	BT3A3_HUMAN	Homo sapiens butyrophilin, subfamily 3, member A3 (BTN3A3), transcript variant 1, mRNA.	298						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						ATACGCTGCAACAGAGCAAGA	0.498000													23	39					0	0	1	0	0
BC042649	0	broad.mit.edu	37	12	131781266	131781266	+	RNA	SNP	A	A	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr12:131781266A>G	uc001uix.3	-	1		c.704T>C								Homo sapiens cDNA clone IMAGE:4826012.																		AGCTGTGGGAAGGGGAAGCAT	0.662000													3	5					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861426	108861426	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr13:108861426T>C	uc001vqn.3	-	1	2464	c.2191A>G	c.(2191-2193)Aag>Gag	p.K731E	LIG4_uc001vqo.3_Missense_Mutation_p.K731E|LIG4_uc010agf.3_Missense_Mutation_p.K731E|LIG4_uc001vqp.3_Missense_Mutation_p.K731E|LIG4_uc010agg.1_Missense_Mutation_p.K664E|LIG4_uc021rmk.1_Missense_Mutation_p.K731E	NM_002312	NP_996820	P49917	DNLI4_HUMAN	Homo sapiens ligase IV, DNA, ATP-dependent (LIG4), transcript variant 1, mRNA.	731	BRCT 1.				DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|T cell differentiation in thymus|T cell receptor V(D)J recombination|cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to X-ray|response to gamma radiation|single strand break repair|somatic stem cell maintenance	DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|condensed chromosome|cytoplasm|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTTTTGGTCTTAAAACATTCT	0.383000								Non-homologous end-joining					26	45					0	0	1	0	0
CREBRF	153222	broad.mit.edu	37	5	172513552	172513552	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr5:172513552C>G	uc003mch.3	+	2	377	c.58C>G	c.(58-60)Cac>Gac	p.H20D	CREBRF_uc003mcf.3_Missense_Mutation_p.H20D|CREBRF_uc003mcg.3_Missense_Mutation_p.H20D|CREBRF_uc011dfd.1_Missense_Mutation_p.H20D	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	Homo sapiens chromosome 5 open reading frame 41 (C5orf41), transcript variant 1, mRNA.	20							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										CTTTCGAAGCCACACCTTTTC	0.408000													50	28					0	0	1	0	0
NPM1	4869	broad.mit.edu	37	5	170819814	170819814	+	Silent	SNP	T	T	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr5:170819814T>A	uc003mbi.3	+	4	698	c.453T>A	c.(451-453)gtT>gtA	p.V151V	NPM1_uc003mbh.3_Silent_p.V151V|NPM1_uc003mbj.3_Silent_p.V151V	NM_002520	NP_002511	P06748	NPM_HUMAN	Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA.	151	Required for interaction with SENP3.				CenH3-containing nucleosome assembly at centromere|DNA repair|anti-apoptosis|cell aging|centrosome cycle|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	NF-kappaB binding|RNA binding|Tat protein binding|histone binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4261)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	4269	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTAGCAAGGTTCCACAGGTAG	0.408000			"""T, F """	"""ALK, RARA, MLF1"""	"""NHL, APL, AML"""								37	64					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139715631	139715631	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:139715631G>A	uc011kqv.2	+	11	1711	c.1476G>A	c.(1474-1476)tgG>tgA	p.W492*	TBXAS1_uc003vvh.3_Nonsense_Mutation_p.W446*|TBXAS1_uc010lne.3_Nonsense_Mutation_p.W378*|TBXAS1_uc011kqu.2_Nonsense_Mutation_p.W397*|TBXAS1_uc003vvi.3_Nonsense_Mutation_p.W446*|TBXAS1_uc011kqw.2_Nonsense_Mutation_p.W426*|TBXAS1_uc003vvj.3_Nonsense_Mutation_p.W446*	NM_001166253	NP_001159725	P24557	THAS_HUMAN	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA.	445					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CTGAGCACTGGCCAAGCCCGG	0.597000													19	43					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11426743	11426743	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:11426743G>C	uc002rbd.1	-	2	695	c.246C>G	c.(244-246)atC>atG	p.I82M		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 (ROCK2), mRNA.	82					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTAGACCTCTGATTTTTTTCA	0.279000													42	196					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108373036	108373036	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr3:108373036C>A	uc003dxd.3	+	18	2500	c.2078C>A	c.(2077-2079)gCa>gAa	p.A693E	DZIP3_uc003dxf.1_Missense_Mutation_p.A693E|DZIP3_uc011bhm.2_Missense_Mutation_p.A144E|DZIP3_uc003dxg.1_Missense_Mutation_p.A416E	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	Homo sapiens DAZ interacting protein 3, zinc finger (DZIP3), mRNA.	693					protein polyubiquitination	cytoplasm	RNA binding|polyubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AAAGAACAAGCAAATCCACAC	0.373000													36	59					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760423	54760423	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:54760423C>T	uc010yer.1	-	2	395	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	LILRB3_uc002qew.2_Intron|LILRB5_uc002qey.3_Missense_Mutation_p.R95Q|LILRB5_uc002qez.3_Missense_Mutation_p.R95Q|LILRB5_uc002qex.3_Missense_Mutation_p.R95Q|LILRB5_uc002qfa.1_Missense_Mutation_p.R85Q|LILRB5_uc010yes.1_Non-coding_Transcript			O75023	LIRB5_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 (LILRB5), transcript variant 1, mRNA.	95	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCAGCGGTATCGCCCTGCACT	0.627000													111	135					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105859066	105859066	+	Missense_Mutation	SNP	C	C	T	rs112504064		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:105859066C>T	uc002tco.1	+	0	867	c.751C>T	c.(751-753)Cgg>Tgg	p.R251W		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	Homo sapiens G protein-coupled receptor 45 (GPR45), mRNA.	251						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						GCGCCTGCAGCGGCAGCAACA	0.652000													82	77					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648140	150648140	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:150648140G>A	uc003wic.3	-	7	2415	c.2014C>T	c.(2014-2016)Cgc>Tgc	p.R672C	KCNH2_uc003wib.3_Missense_Mutation_p.R332C|KCNH2_uc011kux.2_Missense_Mutation_p.R576C|KCNH2_uc003wid.3_Missense_Mutation_p.R332C|KCNH2_uc003wie.3_Missense_Mutation_p.R672C	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1, mRNA.	672					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity	p.A671T(1)		NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTGTGGTAGCGGGCTGTGCCC	0.652000													18	35					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501523	12501523	+	Silent	SNP	T	T	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:12501523T>C	uc010dyt.3	-	3	1893	c.1689A>G	c.(1687-1689)caA>caG	p.Q563Q	ZNF799_uc002mts.4_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	Homo sapiens zinc finger protein 799 (ZNF799), mRNA.	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TACCACATTGTTGACACTCAT	0.413000													17	117					0	0	1	0	0
ADCK3	56997	broad.mit.edu	37	1	227174205	227174205	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:227174205G>A	uc001hqm.1	+	19	5130	c.1711G>A	c.(1711-1713)Gcc>Acc	p.A571T	ADCK3_uc001hqn.1_Missense_Mutation_p.A571T|ADCK3_uc009xeq.1_Missense_Mutation_p.A519T|ADCK3_uc010pvq.1_Missense_Mutation_p.A292T|ADCK3_uc010pvr.1_Missense_Mutation_p.A245T|ADCK3_uc001hqo.1_Missense_Mutation_p.A292T|ADCK3_uc009xer.1_Missense_Mutation_p.A87T	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	Homo sapiens aarF domain containing kinase 3 (ADCK3), nuclear gene encoding mitochondrial protein, mRNA.	571					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						GGAGGCCTTCGCCTCTGATGA	0.592000													32	41					0	0	1	0	0
RNF113B	140432	broad.mit.edu	37	13	98829047	98829047	+	Silent	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr13:98829047C>T	uc001vnk.3	-	0	475	c.444G>A	c.(442-444)cgG>cgA	p.R148R	FARP1_uc001vnh.3_Intron|FARP1_uc001vni.3_Intron|FARP1_uc001vnj.3_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	Homo sapiens ring finger protein 113B (RNF113B), mRNA.	148							nucleic acid binding|zinc ion binding	p.R148Q(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TGTGGATTCCCCGGTAGATGT	0.647000													11	51					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159976	152159976	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:152159976A>T	uc022chn.1	-	0	167	c.167T>A	c.(166-168)tTc>tAc	p.F56Y	PNMA5_uc010ntx.3_Missense_Mutation_p.F56Y|PNMA5_uc010ntw.3_Missense_Mutation_p.F56Y|PNMA5_uc004fgy.4_Missense_Mutation_p.F56Y|PNMA5_uc022chm.1_Missense_Mutation_p.F56Y	NM_052926	NP_443158	Q96PV4	PNMA5_HUMAN	Homo sapiens paraneoplastic antigen like 5 (PNMA5), transcript variant 3, mRNA.	56					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					ttccctcctgaacattctccc	0.522000													56	99					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35381192	35381192	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr9:35381192C>T	uc003zwr.3	+	17	2516	c.2224C>T	c.(2224-2226)Cag>Tag	p.Q742*	UNC13B_uc003zwq.3_Nonsense_Mutation_p.Q742*	NM_006377	NP_006368	O14795	UN13B_HUMAN	Homo sapiens unc-13 homolog B (C. elegans) (UNC13B), mRNA.	742					excretion|induction of apoptosis|intracellular signal transduction	Golgi apparatus|cell junction|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ATACCACGTGCAGTATACATG	0.537000													18	31					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285416	16285416	+	Silent	SNP	G	G	T	rs146449749		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:16285416G>T	uc002gpx.3	+	1	333	c.195G>T	c.(193-195)tcG>tcT	p.S65S	UBB_uc010vwe.1_Silent_p.S65S|UBB_uc021tqs.1_Silent_p.S65S	NM_018955	NP_061828	P0CG47	UBB_HUMAN	Homo sapiens ubiquitin B (UBB), mRNA.	65	Ubiquitin-like 1.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|JNK cascade|M/G1 transition of mitotic cell cycle|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|S phase of mitotic cell cycle|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|innate immune response|mRNA metabolic process|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGAAGGAGTCGACCCTGCACC	0.562000													4	125					0	0	1	0	0
TTC27	55622	broad.mit.edu	37	2	33036105	33036105	+	Silent	SNP	A	A	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:33036105A>T	uc002rom.3	+	16	2286	c.2013A>T	c.(2011-2013)ctA>ctT	p.L671L	TTC27_uc010ymx.2_Silent_p.L621L	NM_017735	NP_001180438	Q6P3X3	TTC27_HUMAN	Homo sapiens tetratricopeptide repeat domain 27 (TTC27), transcript variant 1, mRNA.	671							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						TTAAAATTCTAGTCAGGGCAG	0.403000													34	80					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333707	28333707	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:28333707C>A	uc010jrc.3	+	6	1595	c.1262C>A	c.(1261-1263)aCt>aAt	p.T421N	ZKSCAN3_uc003nle.4_Missense_Mutation_p.T421N|ZKSCAN3_uc003nlf.4_Missense_Mutation_p.T273N	NM_001242894	NP_001229823	Q9BRR0	ZKSC3_HUMAN	Homo sapiens zinc finger with KRAB and SCAN domains 3 (ZKSCAN3), transcript variant 1, mRNA.	421					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						AGAATCCACACTGGGGAGAAG	0.502000													34	21					0	0	1	0	0
HTRA4	203100	broad.mit.edu	37	8	38834215	38834215	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr8:38834215T>C	uc003xmj.3	+	2	843	c.728T>C	c.(727-729)aTt>aCt	p.I243T		NM_153692	NP_710159	P83105	HTRA4_HUMAN	Homo sapiens HtrA serine peptidase 4 (HTRA4), mRNA.	243	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GTCAAGGATATTGACCTTAAA	0.433000													21	25					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44591382	44591382	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:44591382T>G	uc002oyg.1	+	4	1967	c.1751T>G	c.(1750-1752)aTg>aGg	p.M584R	ZNF284_uc010ejd.2_Non-coding_Transcript	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	Homo sapiens zinc finger protein 284 (ZNF284), mRNA.	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				AATCTAGATATGATTTTATCA	0.338000													17	18					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	587405	587405	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr11:587405G>C	uc001lqe.3	+	3	492	c.361G>C	c.(361-363)Ggg>Cgg	p.G121R	PHRF1_uc010qwc.2_Missense_Mutation_p.G121R|PHRF1_uc010qwd.2_Missense_Mutation_p.G120R|PHRF1_uc010qwe.2_Missense_Mutation_p.G117R	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	Homo sapiens PHD and ring finger domains 1 (PHRF1), mRNA.	121							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CCAGGCCGTGGGGACGCCGGA	0.552000													16	55					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107331463	107331463	+	Silent	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr9:107331463C>T	uc011lvo.2	+	0	15	c.15C>T	c.(13-15)aaC>aaT	p.N5N		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	Homo sapiens olfactory receptor, family 13, subfamily C, member 8 (OR13C8), mRNA.	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						AAAGGACCAACGATTCCACGT	0.408000													50	5					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886383	23886383	+	Missense_Mutation	SNP	G	G	A	rs45544633		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr14:23886383G>A	uc001wjx.3	-	31	4604	c.4498C>T	c.(4498-4500)Cgg>Tgg	p.R1500W		NM_000257	NP_000248	P12883	MYH7_HUMAN	Homo sapiens myosin, heavy chain 7, cardiac muscle, beta (MYH7), mRNA.	1500			R -> P (in MPD1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	ATP binding|actin binding|actin-dependent ATPase activity|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1500W(2)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGTTCTCCCGCTTGAAGGTC	0.597000													90	8					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77224931	77224931	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:77224931T>A	uc004ecy.1	-	0	205	c.205A>T	c.(205-207)Aca>Tca	p.T69S	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.4_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	Homo sapiens phosphoglycerate mutase family member 4 (PGAM4), mRNA.	69					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						TCTAGCACTGTCCAGAGGGTC	0.577000													90	112					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578479	7578479	+	Missense_Mutation	SNP	G	G	A	rs28934874		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr17:7578479G>A	uc002gim.2	-	4	645	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	TP53_uc002gig.1_Missense_Mutation_p.P151S|TP53_uc002gih.3_Missense_Mutation_p.P151S|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Missense_Mutation_p.P19S|TP53_uc010cnf.1_Missense_Mutation_p.P19S|TP53_uc002gii.1_Missense_Mutation_p.P19S|TP53_uc010cni.1_Missense_Mutation_p.P151S|TP53_uc010cnh.1_Missense_Mutation_p.P151S|TP53_uc002gij.2_Missense_Mutation_p.P151S|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_Missense_Mutation_p.P58S|TP53_uc002gio.2_Missense_Mutation_p.P19S|TP53_uc010vug.2_Missense_Mutation_p.P112S	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	151	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(134)|p.P151T(30)|p.P151H(27)|p.P151A(22)|p.P151fs*30(13)|p.P151P(12)|p.T150fs*16(10)|p.P152fs*18(9)|p.0?(8)|p.P151L(7)|p.P151R(7)|p.?(5)|p.T150I(4)|p.P151_V173del23(2)|p.P151del(2)|p.D148_T155delDSTPPPGT(2)|p.T150_P153delTPPP(2)|p.P58A(2)|p.P58S(2)|p.P19A(2)|p.Q144_G154del11(2)|p.P19S(2)|p.T150_P151delTP(2)|p.P152_P153del(1)|p.T150R(1)|p.P152fs*28(1)|p.T150fs*31(1)|p.T150fs*23(1)|p.T150K(1)|p.T57fs*16(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.P58T(1)|p.S149fs*17(1)|p.Q144fs*16(1)|p.P19T(1)|p.P152fs*14(1)|p.T18fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	4					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197071386	197071386	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:197071386C>A	uc001gtu.3	-	17	7252	c.6995G>T	c.(6994-6996)cGa>cTa	p.R2332L	ASPM_uc001gtv.3_Intron|ASPM_uc001gtw.4_Missense_Mutation_p.R180L	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	Homo sapiens asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ASPM), transcript variant 1, mRNA.	2332	IQ 22.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GTGCATCTCTCGCATCCTTTT	0.403000													40	44					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60707095	60707095	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr11:60707095T>A	uc001nqn.2	-	5	1526	c.1292A>T	c.(1291-1293)gAg>gTg	p.E431V	SLC15A3_uc001nqo.2_Missense_Mutation_p.S375C	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	Homo sapiens solute carrier family 15, member 3 (SLC15A3), transcript variant 1, mRNA.	431					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GTGTAAGCGCTCCATCTCCAG	0.592000													14	30					0	0	1	0	0
SNRPC	6631	broad.mit.edu	37	6	34725706	34725706	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr6:34725706G>A	uc003ojt.2	+	1	476	c.26G>A	c.(25-27)tGc>tAc	p.C9Y	SNRPC_uc021yyv.1_Intron|SNRPC_uc021yyw.1_Missense_Mutation_p.C30Y	NM_003093	NP_003084	P09234	RU1C_HUMAN	Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC), transcript variant 1, mRNA.	9					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)	6						TGTGACTACTGCGATACATAC	0.368000													20	40					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125082754	125082754	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr8:125082754G>A	uc003yqw.3	+	29	4087	c.3881G>A	c.(3880-3882)tGg>tAg	p.W1294*	AK057332_uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	Homo sapiens fer-1-like 6 (C. elegans) (FER1L6), mRNA.	1294						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TTTGAAGACTGGGTGAAAACT	0.418000													16	88					0	0	1	0	0
THAP8	199745	broad.mit.edu	37	19	36526381	36526381	+	Silent	SNP	G	G	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:36526381G>T	uc002oda.1	-	3	1331	c.786C>A	c.(784-786)gcC>gcA	p.A262A	BC071809_uc002ocy.3_Intron|CLIP3_uc010eeq.2_5'Flank|CLIP3_uc002ocz.2_5'Flank|THAP8_uc010xtb.1_Silent_p.A219A|THAP8_uc010xtc.1_Non-coding_Transcript	NM_152658	NP_689871	Q8NA92	THAP8_HUMAN	Homo sapiens THAP domain containing 8 (THAP8), mRNA.	262							DNA binding|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	8	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCTCCGGCTTGGCATCCACTG	0.537000													16	69					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107015549	107015549	+	Silent	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr10:107015549G>A	uc001kyi.1	+	23	3554	c.3327G>A	c.(3325-3327)caG>caA	p.Q1109Q		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	Homo sapiens sortilin-related VPS10 domain containing receptor 3 (SORCS3), mRNA.	1109						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATGTCACACAGCTGACGTTAG	0.443000													27	34					0	0	1	0	0
FHOD3	80206	broad.mit.edu	37	18	34297864	34297864	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr18:34297864G>A	uc021uiv.1	+	18	2700	c.2603G>A	c.(2602-2604)cGg>cAg	p.R868Q	FHOD3_uc002kzs.1_Missense_Mutation_p.R693Q|FHOD3_uc002kzt.1_Missense_Mutation_p.R676Q|FHOD3_uc010dmz.1_Missense_Mutation_p.R408Q|FHOD3_uc010dna.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	Homo sapiens formin homology 2 domain containing 3 (FHOD3), mRNA.	676	Pro-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				ACCAACAAACGGTTCATGCTT	0.542000													49	59					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101912152	101912152	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrX:101912152C>T	uc010nod.3	+	2	3953	c.3311C>T	c.(3310-3312)cCt>cTt	p.P1104L	ARMCX5-GPRASP2_uc022cay.1_Intron|GPRASP1_uc022cbc.1_Missense_Mutation_p.P1104L|GPRASP1_uc004ejj.4_Missense_Mutation_p.P1104L|GPRASP1_uc004eji.4_Missense_Mutation_p.P1104L|GPRASP1_uc022cbd.1_Missense_Mutation_p.P1104L	NM_001099411	NP_055525	Q5JY77	GASP1_HUMAN	Homo sapiens G protein-coupled receptor associated sorting protein 1 (GPRASP1), transcript variant 3, mRNA.	1104	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTGCTTCAGCCTGATCAGCCT	0.488000													101	93					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31464365	31464365	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr5:31464365C>A	uc003jhg.2	-	18	2911	c.2552G>T	c.(2551-2553)gGc>gTc	p.G851V	DROSHA_uc003jhh.2_Missense_Mutation_p.G814V|DROSHA_uc003jhi.2_Missense_Mutation_p.G814V	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	Homo sapiens drosha, ribonuclease type III (DROSHA), transcript variant 1, mRNA.	851	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				RNA processing|gene silencing by RNA|ribosome biogenesis	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						AGAACGGATGCCAGTTTTCCA	0.428000													13	27					0	0	1	0	0
USP1	7398	broad.mit.edu	37	1	62908931	62908931	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:62908931T>A	uc001daj.2	+	4	826	c.498T>A	c.(496-498)aaT>aaA	p.N166K	USP1_uc001dak.2_Missense_Mutation_p.N166K|USP1_uc001dal.2_Missense_Mutation_p.N166K	NM_001017415	NP_003359	O94782	UBP1_HUMAN	Homo sapiens ubiquitin specific peptidase 1 (USP1), transcript variant 2, mRNA.	166					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		TTCTCTTAAATCCAGAGAAAT	0.368000													30	37					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7585559	7585559	+	Silent	SNP	A	A	G			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:7585559A>G	uc002mgn.2	+	1	1601	c.1431A>G	c.(1429-1431)aaA>aaG	p.K477K	ZNF358_uc021unu.1_Silent_p.K477K|MCOLN1_uc010dvh.2_5'Flank|MCOLN1_uc002mgo.3_5'Flank|MCOLN1_uc002mgp.3_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	Homo sapiens zinc finger protein 358 (ZNF358), mRNA.	477					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						ccagctccaaacccctccccg	0.682000													12	27					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr9:20414340G>A	uc003zoe.2	-	4	763	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_uc011lne.1_Silent_p.S136S|MLLT3_uc011lnf.1_Silent_p.S165S|MLLT3_uc003zof.3_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mRNA.	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)|p.S168S(10)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	76					0	0	1	0	0
LOC283788	283788	broad.mit.edu	37	GL000219.1	83216	83216	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chrGL000219.1:83216G>C	uc022brb.1	-	3	451	c.138C>G	c.(136-138)atC>atG	p.I46M	LOC283788_uc011mfq.2_Non-coding_Transcript					Homo sapiens FSHD region gene 1 pseudogene (LOC283788), non-coding RNA.																		TCGTTACCTTGATCATTTCTT	0.358000													3	20					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916930	178916930	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr3:178916930G>T	uc003fjk.3	+	1	474	c.317G>T	c.(316-318)gGc>gTc	p.G106V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	Homo sapiens phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA), mRNA.	106	PI3K-ABD.		G -> V (in cancer; shows an increase in lipid kinase activity).		T cell costimulation|T cell receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G106V(12)|p.G106_R108del(4)|p.G106_R108delGNR(3)|p.G106R(2)|p.E103_G106>D(2)|p.G106A(2)|p.P104_G106>R(1)|p.G106G(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAACCAGTAGGCAACCGTGAA	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			102	38					0	0	1	0	0
USP1	7398	broad.mit.edu	37	1	62910418	62910418	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:62910418delC	uc001daj.2	+	5	895	c.567delC	c.(565-567)aacfs	p.N189fs	USP1_uc001dak.2_Frame_Shift_Del_p.N189fs|USP1_uc001dal.2_Frame_Shift_Del_p.N189fs	NM_001017415	NP_003359	O94782	UBP1_HUMAN	Homo sapiens ubiquitin specific peptidase 1 (USP1), transcript variant 2, mRNA.	189					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		GGGAACTCAACCCTATGTATG	0.303													27	39	---	---	---	---					
C1orf106	55765	broad.mit.edu	37	1	200881172	200881172	+	Frame_Shift_Del	DEL	C	C	-	rs296521	by1000genomes	TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr1:200881172delC	uc001gvo.3	+	8	1848	c.1806delC	c.(1804-1806)cgcfs	p.R602fs	C1orf106_uc010ppm.2_Frame_Shift_Del_p.R517fs	NM_018265	NP_001136041	Q3KP66	CA106_HUMAN	Homo sapiens chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mRNA.	602										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GGAGCACCCGCCCCCACTCAC	0.716													2	4	---	---	---	---					
MYT1L	23040	broad.mit.edu	37	2	1946857	1946859	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr2:1946857_1946859delCTC	uc002qxe.3	-	8	1227_1229	c.400_402delGAG	c.(400-402)gagdel	p.E134del	MYT1L_uc002qxd.3_In_Frame_Del_p.E134del	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	Homo sapiens myelin transcription factor 1-like (MYT1L), mRNA.	134	Asp/Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		cctcctcgatctcctcctcctcc	0.576													4	4	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr3:184039744_184039746delGAA	uc003fnp.3	+	9	1643_1645	c.1372_1374delGAA	c.(1372-1374)gaadel	p.E465del	EIF4G1_uc003fno.2_In_Frame_Del_p.E406del|EIF4G1_uc010hxw.2_In_Frame_Del_p.E301del|EIF4G1_uc010hxx.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnt.3_In_Frame_Del_p.E176del|EIF4G1_uc010hxy.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnq.3_In_Frame_Del_p.E378del|EIF4G1_uc003fnr.3_In_Frame_Del_p.E301del|EIF4G1_uc003fns.3_In_Frame_Del_p.E425del|EIF4G1_uc003fnv.4_In_Frame_Del_p.E465del|EIF4G1_uc003fnw.3_In_Frame_Del_p.E472del|EIF4G1_uc003fnx.3_In_Frame_Del_p.E269del	NM_198241	NP_937885	Q04637	IF4G1_HUMAN	Homo sapiens eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1), transcript variant 2, mRNA.	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.562													7	226	---	---	---	---					
C7orf43	55262	broad.mit.edu	37	7	99755809	99755809	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr7:99755809delG	uc003utr.3	-	0	494	c.314delC	c.(313-315)ccafs	p.P105fs	C7orf43_uc010lgo.3_5'Flank|C7orf43_uc010lgp.3_5'Flank|C7orf43_uc011kjj.2_5'Flank|C7orf43_uc003uts.3_Intron|C7orf43_uc022aih.1_5'Flank	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	Homo sapiens chromosome 7 open reading frame 43 (C7orf43), mRNA.	105	Gly-rich.									breast(1)|endometrium(3)|large_intestine(3)|lung(2)|prostate(1)	10	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCTCCCCCTGGGGGCTCCGA	0.756													2	4	---	---	---	---					
C10orf137	26098	broad.mit.edu	37	10	127414264	127414266	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr10:127414264_127414266delGGA	uc001liq.1	+	5	942_944	c.649_651delGGA	c.(649-651)ggadel	p.G217del	C10orf137_uc001lin.3_In_Frame_Del_p.G217del|C10orf137_uc001lip.1_5'UTR|C10orf137_uc001lio.1_In_Frame_Del_p.G217del	NM_001202438	NP_001189367	Q3B7T1	EDRF1_HUMAN	Homo sapiens chromosome 10 open reading frame 137 (C10orf137), transcript variant 1, mRNA.	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CAATGGTGATGGAGCCGCTCAGC	0.448													21	31	---	---	---	---					
MKRN9P	400058	broad.mit.edu	37	12	88178272	88178274	+	In_Frame_Del	DEL	GCC	GCC	-	rs10577456		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr12:88178272_88178274delGCC	uc021rbq.1	-	0	215_217	c.72_74delGGC	c.(70-75)gcggca>gca	p.24_25AA>A						Homo sapiens makorin ring finger protein 9, pseudogene (MKRN9P), non-coding RNA.																		Ggccgctgctgccgccgccgccg	0.685													3	5	---	---	---	---					
USP10	9100	broad.mit.edu	37	16	84778803	84778803	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr16:84778803delC	uc010voe.2	+	4	979	c.728delC	c.(727-729)gcafs	p.A243fs	USP10_uc002fii.3_Frame_Shift_Del_p.A239fs|USP10_uc010vof.2_Intron|USP10_uc002fij.3_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	Homo sapiens ubiquitin specific peptidase 10 (USP10), mRNA.	239					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						ACCAGGACTGCAGGGCAGCCA	0.627													19	3	---	---	---	---					
THOC1	9984	broad.mit.edu	37	18	214519	214520	+	Splice_Site	INS	-	-	TTG	rs142588910		TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr18:214519_214520insTTG	uc002kkj.4	-	21	2120	c.2080_splice	c.e21+1		THOC1_uc002kkh.4_Splice_Site	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	Homo sapiens THO complex 1 (THOC1), mRNA.						RNA splicing|apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|signal transduction|transcription, DNA-dependent	THO complex part of transcription export complex|cytoplasm|nuclear matrix|nuclear speck	DNA binding|RNA binding|protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	20		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CTGTACAACAATTGTTATAAAA	0.351													3	3	---	---	---	---					
ZNF556	80032	broad.mit.edu	37	19	2878502	2878502	+	Splice_Site	DEL	A	A	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:2878502delA	uc002lwq.3	+	4	1631	c.1544_splice	c.e4+1			NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	Homo sapiens zinc finger protein 556 (ZNF556), mRNA.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		cgtctctactaaaaaaaaaaa	0.557													4	9	---	---	---	---					
SAFB2	9667	broad.mit.edu	37	19	5594052	5594066	+	In_Frame_Del	DEL	CGCTCCCGCTCCATG	CGCTCCCGCTCCATG	-			TCGA-N7-A59B-01A-11D-A28R-08	TCGA-N7-A59B-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c136f0c7-c211-4ac9-a755-1ac6b32b1196	8cc077f9-7398-4135-b4c3-dc18247f0879	g.chr19:5594052_5594066delCGCTCCCGCTCCATG	uc002mcd.3	-	14	2255_2269	c.2043_2057delCATGGAGCGGGAGCG	c.(2041-2058)cgcatggagcgggagcgg>cgg	p.681_686RMERER>R		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	Homo sapiens scaffold attachment factor B2 (SAFB2), mRNA.	681	Arg-rich.|Glu-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|RNA binding|nucleotide binding|protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GCGCTCCAGCCGCTCCCGCTCCATGCGCTCCCGCT	0.716													14	11	---	---	---	---					
