Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HOMEZ	57594	broad.mit.edu	37	14	23746240	23746240	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr14:23746240C>G	uc001wja.2	-	1	345	c.197G>C	c.(196-198)aGc>aCc	p.S66T	HOMEZ_uc001wjb.2_Missense_Mutation_p.S68T	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	Homo sapiens homeobox and leucine zipper encoding (HOMEZ), mRNA.	66						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTGTTCATTGCTGTCTAGCTC	0.537000													18	60					0	0	1	0	0
LOC283788	283788	broad.mit.edu	37	GL000219.1	83307	83307	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chrGL000219.1:83307G>T	uc022brb.1	-	3	360	c.47C>A	c.(46-48)gCt>gAt	p.A16D	LOC283788_uc011mfq.2_Non-coding_Transcript					Homo sapiens FSHD region gene 1 pseudogene (LOC283788), non-coding RNA.																		GGCCAACAAAGCCATTTTCCC	0.373000													3	14					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	106586202	106586202	+	RNA	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr14:106586202T>C	uc021ser.1	-	1811		c.34094A>G			abParts_uc001ysv.3_Non-coding_Transcript					Parts of antibodies, mostly variable regions.																		TACAAGGAGTTCTTGGCATTT	0.507000													25	91					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36128374	36128374	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr14:36128374G>A	uc001wtj.3	-	26	4230	c.3839C>T	c.(3838-3840)tCg>tTg	p.S1280L	RALGAPA1_uc010amp.3_Non-coding_Transcript|RALGAPA1_uc001wti.3_Missense_Mutation_p.S1280L|RALGAPA1_uc010tpv.2_Missense_Mutation_p.S1293L|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1327L	NM_194301	NP_919277	Q6GYQ0	RGPA1_HUMAN	Homo sapiens Ral GTPase activating protein, alpha subunit 1 (catalytic) (RALGAPA1), transcript variant 2, mRNA.	1280					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	Ral GTPase activator activity|protein heterodimerization activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ATCTCTTGCCGAGCTTAATAC	0.353000													12	3					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36488358	36488358	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:36488358C>T	uc021wdj.1	+	13	1541	c.1450C>T	c.(1450-1452)Cgg>Tgg	p.R484W	CTNNBL1_uc002xhh.3_Missense_Mutation_p.R297W|CTNNBL1_uc002xhi.3_Non-coding_Transcript|CTNNBL1_uc002xhj.3_Missense_Mutation_p.R232W	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	Homo sapiens catenin, beta like 1 (CTNNBL1), mRNA.	484					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GTTCTACCTCCGGCGCCTGGA	0.537000													30	16					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344089	248344089	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:248344089C>G	uc010pzf.2	+	0	802	c.802C>G	c.(802-804)Cca>Gca	p.P268A		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily M, member 2 (OR2M2), mRNA.	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGATCACTCCCCAACGCAGGA	0.502000													101	139					0	0	1	0	0
FAM50B	26240	broad.mit.edu	37	6	3850736	3850736	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:3850736G>A	uc003mvu.3	+	1	803	c.691G>A	c.(691-693)Ggc>Agc	p.G231S	FAM50B_uc021ykt.1_Missense_Mutation_p.G231S	NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	Homo sapiens family with sequence similarity 50, member B (FAM50B), mRNA.	231						nucleus		p.A230A(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCGCTCCGCCGGCGTGGAGCA	0.657000													86	77					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148916171	148916171	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:148916171G>T	uc003ewy.4	-	8	1949	c.1696C>A	c.(1696-1698)Cat>Aat	p.H566N	CP_uc011bnr.2_Non-coding_Transcript|CP_uc003ewx.4_Missense_Mutation_p.H347N|CP_uc003ewz.3_Missense_Mutation_p.H566N|CP_uc010hvf.1_Missense_Mutation_p.H292N	NM_000096	NP_000087	P00450	CERU_HUMAN	Homo sapiens ceruloplasmin (ferroxidase) (CP), mRNA.	566	F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CCATTTGCATGTAAACTTCCT	0.353000													6	48					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68956262	68956262	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:68956262C>G	uc003hdt.1	-	2	310	c.261G>C	c.(259-261)agG>agC	p.R87S		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	Homo sapiens transmembrane protease, serine 11F (TMPRSS11F), mRNA.	87	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						TCTGATGACTCCTTTCTATAA	0.294000													4	18					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183866921	183866921	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:183866921C>G	uc002upc.3	-	4	848	c.446G>C	c.(445-447)cGa>cCa	p.R149P	NCKAP1_uc002upb.3_Missense_Mutation_p.R155P	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	Homo sapiens NCK-associated protein 1 (NCKAP1), transcript variant 1, mRNA.	149					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding	p.R155Q(1)		breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTCTTCAATTCGAGACAGCAG	0.313000													5	36					0	0	1	0	0
TOR3A	64222	broad.mit.edu	37	1	179064258	179064258	+	Missense_Mutation	SNP	G	G	T	rs78309022		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:179064258G>T	uc001gmd.3	+	5	1251	c.1099G>T	c.(1099-1101)Gcc>Tcc	p.A367S	TOR3A_uc010pnd.2_Missense_Mutation_p.A151S	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	Homo sapiens torsin family 3, member A (TOR3A), mRNA.	367					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|urinary_tract(1)	13						GGATGAAATAGCCCAGATGAT	0.512000													5	233					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475639	75475639	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:75475639T>C	uc003dpp.4	-	6	958	c.599A>G	c.(598-600)cAc>cGc	p.H200R	FAM86DP_uc003dps.4_Non-coding_Transcript|FAM86DP_uc003dpq.4_Missense_Mutation_p.H108R|FAM86DP_uc003dpr.4_Non-coding_Transcript					Homo sapiens family with sequence similarity 86, member D, pseudogene (FAM86DP), non-coding RNA.									p.H284R(1)									CTCTGGGTTGTGGACGGTAAA	0.662000													3	10					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23299857	23299857	+	RNA	SNP	A	A	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr19:23299857A>T	uc002nrb.1	+	0		c.81A>T								Synthetic construct DNA, clone: pF1KB7766, Homo sapiens ZNF730 gene for zinc finger protein 730, without stop codon, in Flexi system.											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						CCGAAGCTCCAATTTTCGTCT	0.637000													36	19					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83724416	83724416	+	Silent	SNP	G	G	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chrX:83724416G>T	uc011mqv.2	-	3	562	c.315C>A	c.(313-315)gtC>gtA	p.V105V	HDX_uc004eel.2_Silent_p.V47V|HDX_uc004eek.2_Silent_p.V105V	NM_001177479	NP_001170949	Q7Z353	HDX_HUMAN	Homo sapiens highly divergent homeobox (HDX), transcript variant 1, mRNA.	105						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.V105A(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CAGTTACAATGACATCATTAT	0.413000													22	9					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	121100275	121100275	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:121100275G>T	uc003eec.4	+	22	2695	c.2555G>T	c.(2554-2556)tGt>tTt	p.C852F	STXBP5L_uc011bji.2_Missense_Mutation_p.C828F	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	Homo sapiens syntaxin binding protein 5-like (STXBP5L), mRNA.	852					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATCTCTCCTTGTCTGTTCGTT	0.408000													55	83					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73732658	73732658	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:73732658C>T	uc002jpg.3	+	15	2060	c.1873C>T	c.(1873-1875)Ctc>Ttc	p.L625F	ITGB4_uc002jph.3_Missense_Mutation_p.L625F|ITGB4_uc010dgo.3_Missense_Mutation_p.L625F|ITGB4_uc002jpi.4_Missense_Mutation_p.L625F|ITGB4_uc010dgp.1_Missense_Mutation_p.L625F|ITGB4_uc002jpj.3_Missense_Mutation_p.L625F|ITGB4_uc010wsh.1_Missense_Mutation_p.L180F	NM_000213	NP_000204	P16144	ITB4_HUMAN	Homo sapiens integrin, beta 4 (ITGB4), transcript variant 1, mRNA.	625				IHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDEL KRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHK KK -> STRASARTYAPACSARRGAPARRRGARVRNATSRS RWWTSLREARRWWCAAPSGTRMTTAPTATPWKVTAPLGPTA LSWCTRRR (in Ref. 5; CAB61345).	cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACCCGGGCCTCTGCGAGGA	0.657000													12	42					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151271532	151271532	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:151271532C>A	uc001exr.3	-	9	2442	c.1803G>T	c.(1801-1803)gaG>gaT	p.E601D	PI4KB_uc001exs.3_Missense_Mutation_p.E574D|PI4KB_uc001exu.3_Missense_Mutation_p.E574D|PI4KB_uc010pcw.2_Missense_Mutation_p.E257D|PI4KB_uc001ext.3_Missense_Mutation_p.E589D	NM_002651	NP_001185704	Q9UBF8	PI4KB_HUMAN	Homo sapiens phosphatidylinositol 4-kinase, catalytic, beta (PI4KB), transcript variant 1, mRNA.	589	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	Golgi apparatus|endosome|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGGCACTCGCTCCTGTTCCC	0.473000													31	87					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511839	195511839	+	Silent	SNP	A	A	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:195511839A>T	uc021xjp.1	-	1	6768	c.6612T>A	c.(6610-6612)ggT>ggA	p.G2204G	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	993					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGTGGCCTGACCTGTGGATG	0.597000													3	18					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164741472	164741472	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:164741472T>C	uc003fei.3	-	25	3048	c.2985A>G	c.(2983-2985)atA>atG	p.I995M		NM_001041	NP_001032	P14410	SUIS_HUMAN	Homo sapiens sucrase-isomaltase (alpha-glucosidase) (SI), mRNA.	995	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	Golgi apparatus|apical plasma membrane|brush border|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.G994C(1)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGTCAGCTGTTATACCCATGG	0.403000										HNSCC(35;0.089)			7	61					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:39274291T>C	uc002hvz.3	-	0	316	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(8)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													4	12					0	0	1	0	0
HNRNPL	3191	broad.mit.edu	37	19	39330769	39330769	+	Silent	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr19:39330769G>A	uc021uuh.1	-	7	1211	c.1200C>T	c.(1198-1200)ttC>ttT	p.F400F	HNRNPL_uc002ojj.1_Silent_p.F56F|HNRNPL_uc010ege.1_Silent_p.F56F|HNRNPL_uc002ojk.3_Silent_p.F56F|HNRNPL_uc002ojl.3_Silent_p.F56F|HNRNPL_uc021uui.1_Silent_p.F267F|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojp.1_Silent_p.F56F|HNRNPL_uc010xun.2_3'UTR	NM_001533	NP_001005335	P14866	HNRPL_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRNPL), transcript variant 1, mRNA.	400	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	RNA binding|nucleotide binding|protein binding|transcription regulatory region DNA binding	p.F400F(2)|p.F267F(1)|p.F400L(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			AGAAGACATTGAAGACTCGGT	0.577000													44	9					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97681791	97681791	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:97681791C>A	uc003ppb.3	-	11	1514	c.1248G>T	c.(1246-1248)tgG>tgT	p.W416C	MIR548H3_uc021zda.1_Intron|MMS22L_uc011eaf.2_Intron|MMS22L_uc010kcn.1_Missense_Mutation_p.W190C	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	Homo sapiens MMS22-like, DNA repair protein (MMS22L), mRNA.	416					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						TGTTTGGCTCCCAGAAATCAC	0.323000													28	20					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38457436	38457436	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:38457436C>G	uc003tgu.3	-	16	1603	c.1387G>C	c.(1387-1389)Gag>Cag	p.E463Q	AMPH_uc003tgv.3_Intron|AMPH_uc003tgt.3_Intron|AMPH_uc003tgw.1_Intron|AMPH_uc010kxl.1_Intron	NM_001635	NP_001626	P49418	AMPH_HUMAN	Homo sapiens amphiphysin (AMPH), transcript variant 1, mRNA.	463					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						ACTGCCTCCTCCACTGGCTCC	0.602000													26	30					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002239	98002239	+	Silent	SNP	A	A	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:98002239A>C	uc003dsj.1	+	0	508	c.508A>C	c.(508-510)Aga>Cga	p.R170R		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily H, member 2 (OR5H2), mRNA.	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CCTTATATTCAGATTAACCTT	0.328000													25	60					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658188	72658188	+	Missense_Mutation	SNP	T	T	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:72658188T>G	uc003txs.1	-	12	1724	c.796A>C	c.(796-798)Att>Ctt	p.I266L	FKBP6_uc003twz.2_Intron					Homo sapiens GTF2I repeat domain containing 2 pseudogene 1 (GTF2IRD2P1), non-coding RNA.																		ttcggatgaattatacaacag	0.512000													74	99					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39735322	39735322	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:39735322C>A	uc001rly.3	-	13	2326	c.1906G>T	c.(1906-1908)Gaa>Taa	p.E636*	KIF21A_uc001rlw.3_5'Flank|KIF21A_uc001rlx.3_Nonsense_Mutation_p.E623*|KIF21A_uc001rlz.3_Nonsense_Mutation_p.E623*|KIF21A_uc010skl.2_Nonsense_Mutation_p.E623*	NM_001173464	NP_001166935	Q7Z4S6	KI21A_HUMAN	Homo sapiens kinesin family member 21A (KIF21A), transcript variant 1, mRNA.	636					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TCATCTGATTCAGAATCTGAT	0.388000													17	19					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152432754	152432754	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:152432754G>A	uc021vrb.1	-	76	11745	c.11716C>T	c.(11716-11718)Cgg>Tgg	p.R3906W	NEB_uc002txr.3_Missense_Mutation_p.R372W|NEB_uc002txu.3_Missense_Mutation_p.R5607W|NEB_uc021vrc.1_Missense_Mutation_p.R5607W|NEB_uc010fnx.3_Missense_Mutation_p.R3894W|NEB_uc021vrd.1_Missense_Mutation_p.R3906W	NM_004543	NP_004534	P20929	NEBU_HUMAN	Homo sapiens nebulin (NEB), transcript variant 3, mRNA.	3906					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	Z disc|actin cytoskeleton|cytosol	actin binding|structural constituent of muscle	p.R3906Q(1)		NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACAGGCGTCCGATAGACACTG	0.448000													51	25					0	0	1	0	0
NCK1	4690	broad.mit.edu	37	3	136667191	136667191	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:136667191C>T	uc003erh.3	+	3	1160	c.1030C>T	c.(1030-1032)Cgt>Tgt	p.R344C	NCK1_uc011bme.2_Missense_Mutation_p.R280C	NM_006153	NP_006144	P16333	NCK1_HUMAN	Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA.	344	SH2.				T cell activation|T cell receptor signaling pathway|axon guidance|positive regulation of T cell proliferation|positive regulation of actin filament polymerization|regulation of translation|signal complex assembly	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						CATTGGGCAGCGTAAATTCAG	0.348000													19	32					0	0	1	0	0
RNASEH2B	79621	broad.mit.edu	37	13	51530513	51530513	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:51530513C>T	uc001vfa.4	+	10	1241	c.842C>T	c.(841-843)gCa>gTa	p.A281V	RNASEH2B_uc001vfb.4_Intron	NM_024570	NP_078846	Q5TBB1	RNH2B_HUMAN	Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant 1, mRNA.	281					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		AAAATGACTGCAGCTCAGAAG	0.289000													4	1					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525481	248525481	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:248525481T>C	uc001ieh.1	+	0	599	c.599T>C	c.(598-600)tTc>tCc	p.F200S		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily T, member 4 (OR2T4), mRNA.	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTCCCCTTCCGTGGATCC	0.493000													65	183					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797646	93797646	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr11:93797646G>A	uc001pep.2	+	3	935	c.778G>A	c.(778-780)Gct>Act	p.A260T		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	Homo sapiens hephaestin-like 1 (HEPHL1), mRNA.	260	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CAAGAAAGATGCTGTTTTCCA	0.378000													21	3					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46553965	46553965	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:46553965C>T	uc010tfw.1	-	9	1901	c.1895G>A	c.(1894-1896)cGt>cAt	p.R632H	ZC3H13_uc001vas.1_Missense_Mutation_p.R632H|ZC3H13_uc001vat.1_Missense_Mutation_p.R632H	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	Homo sapiens zinc finger CCCH-type containing 13 (ZC3H13), mRNA.	632	Arg/Ser-rich.						nucleic acid binding|zinc ion binding	p.R631C(1)		cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTGTTGTCACGACGGTCTCG	0.373000													16	103					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41741044	41741044	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr21:41741044C>T	uc002yyq.1	-	3	1089	c.637G>A	c.(637-639)Gcc>Acc	p.A213T	DSCAM_uc002yyr.1_Non-coding_Transcript	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA.	213	Ig-like C2-type 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AAAAGTCTGGCGCTGTTGCTC	0.428000													28	38					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4119118	4119118	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:4119118C>A	uc003smx.3	+	21	3365	c.3226C>A	c.(3226-3228)Ctg>Atg	p.L1076M	SDK1_uc010kso.3_Missense_Mutation_p.L352M	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	Homo sapiens sidekick cell adhesion molecule 1 (SDK1), transcript variant 1, mRNA.	1076	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCATCCAACCTGGTCATTTC	0.547000													90	20					0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66500839	66500839	+	RNA	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr9:66500839T>C	uc004aed.1	+	2		c.932T>C								Homo sapiens uncharacterized LOC442421 (LOC442421), non-coding RNA.																		AACCACCTGGTGCCCAGGGCT	0.637000													5	33					0	0	1	0	0
AK021933	0	broad.mit.edu	37	GL000195.1	31536	31536	+	RNA	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chrGL000195.1:31536C>T	uc003woi.3	-	0		c.445G>A								Homo sapiens cDNA FLJ11871 fis, clone HEMBA1007052.																		GAGACTACCTCTCCCAGCAAG	0.557000													6	6					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636638	73636638	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:73636638C>T	uc001vje.3	+	1	1225	c.901C>T	c.(901-903)Ccc>Tcc	p.P301S	KLF5_uc001vjd.3_Missense_Mutation_p.P210S	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Homo sapiens Kruppel-like factor 5 (intestinal) (KLF5), mRNA.	301			P -> S (in a colorectal cancer sample; somatic mutation).		transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.P301S(2)		breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CACTTACTTTCCCCCGTCACC	0.512000													28	19					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620650	144620650	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr8:144620650G>A	uc003yyd.2	-	1	916	c.887C>T	c.(886-888)tCg>tTg	p.S296L		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	Homo sapiens zinc finger CCCH-type containing 3 (ZC3H3), mRNA.	296					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CACAACCAGCGAGGCCTCCCG	0.627000													50	98					0	0	1	0	0
RFC4	5984	broad.mit.edu	37	3	186510374	186510374	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:186510374A>G	uc003fqz.3	-	6	803	c.580T>C	c.(580-582)Tgt>Cgt	p.C194R	RFC4_uc011bsc.2_Missense_Mutation_p.C194R|RFC4_uc011bsd.2_Missense_Mutation_p.C194R	NM_002916	NP_853551	P35249	RFC4_HUMAN	Homo sapiens replication factor C (activator 1) 4, 37kDa (RFC4), transcript variant 1, mRNA.	194					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle|cell cycle checkpoint|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding	p.R193I(1)		breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		AATTTTGAACATCTAGAGGTC	0.363000													20	240					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33328602	33328602	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:33328602C>T	uc002xav.3	-	11	8029	c.5458G>A	c.(5458-5460)Gtg>Atg	p.V1820M	NCOA6_uc002xaw.3_Missense_Mutation_p.V1820M|NCOA6_uc021wcd.1_Intron|NCOA6_uc021wce.1_Missense_Mutation_p.V1820M|NCOA6_uc021wcf.1_Intron	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	Homo sapiens nuclear receptor coactivator 6 (NCOA6), transcript variant 1, mRNA.	1820	EP300/CRSP3-binding region.				DNA recombination|DNA repair|DNA replication|brain development|cellular lipid metabolic process|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						ATTTTGTCCACTTTTCCTTTG	0.468000													62	46					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129867279	129867279	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:129867279C>T	uc003igp.2	-	15	1828	c.1322G>A	c.(1321-1323)aGt>aAt	p.S441N	SCLT1_uc003ign.2_Missense_Mutation_p.S105N|SCLT1_uc003igo.2_Missense_Mutation_p.S51N|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	Homo sapiens sodium channel and clathrin linker 1 (SCLT1), mRNA.	441			S -> C (in dbSNP:rs10028124).			centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TCTGTAATCACTCTCATTTCC	0.348000													9	5					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67022537	67022537	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:67022537C>T	uc002jhu.3	-	15	2265	c.2122G>A	c.(2122-2124)Ggc>Agc	p.G708S	ABCA9_uc010dez.3_Missense_Mutation_p.G708S	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 9 (ABCA9), mRNA.	708	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TAGCCTATGCCCCATTTCTTC	0.423000													299	22					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578271	7578271	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr17:7578271T>C	uc002gim.2	-	5	772	c.578A>G	c.(577-579)cAt>cGt	p.H193R	TP53_uc002gig.1_Missense_Mutation_p.H193R|TP53_uc002gih.3_Missense_Mutation_p.H193R|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Missense_Mutation_p.H61R|TP53_uc010cnf.1_Missense_Mutation_p.H61R|TP53_uc002gii.1_Missense_Mutation_p.H61R|TP53_uc010cni.1_Missense_Mutation_p.H193R|TP53_uc010cnh.1_Missense_Mutation_p.H193R|TP53_uc002gij.2_Missense_Mutation_p.H193R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100R|TP53_uc002gio.2_Missense_Mutation_p.H61R|TP53_uc010vug.2_Missense_Mutation_p.H154R	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(152)|p.H193L(77)|p.Q192*(71)|p.H193P(32)|p.H193Y(27)|p.H193D(9)|p.0?(8)|p.A189_V197delAPPQHLIRV(8)|p.H193fs*16(6)|p.?(6)|p.Q192R(5)|p.P191_E198>Q(4)|p.H193N(4)|p.H61R(4)|p.H100R(4)|p.H100L(4)|p.H61L(4)|p.Q192H(3)|p.H193_I195delHLI(2)|p.P191fs*53(2)|p.H193H(2)|p.Q192Q(2)|p.Q192K(2)|p.H61P(2)|p.H100P(2)|p.H193_I195>AP(2)|p.A189fs*53(1)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.P98_E105>Q(1)|p.Q192del(1)|p.Q192fs*56(1)|p.Q192fs*16(1)|p.Q192fs*30(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	4					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50407647	50407647	+	Missense_Mutation	SNP	G	G	A	rs144505438		TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr20:50407647G>A	uc002xwh.4	-	1	1476	c.1375C>T	c.(1375-1377)Ctc>Ttc	p.L459F	SALL4_uc010gii.3_Intron|SALL4_uc002xwi.4_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	Homo sapiens sal-like 4 (Drosophila) (SALL4), mRNA.	459					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGTACAGAGAGTGCATAGGGG	0.537000													33	77					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475607	75475607	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:75475607C>T	uc003dpp.4	-	6	990	c.631G>A	c.(631-633)Gag>Aag	p.E211K	FAM86DP_uc003dps.4_Non-coding_Transcript|FAM86DP_uc003dpq.4_Missense_Mutation_p.E119K|FAM86DP_uc003dpr.4_Non-coding_Transcript					Homo sapiens family with sequence similarity 86, member D, pseudogene (FAM86DP), non-coding RNA.																		TCACCTAGCTCGGTGGTGAAC	0.652000													3	11					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:25161397C>G	uc001upm.3	+	7		c.921C>G			TPTE2P6_uc001upn.3_Non-coding_Transcript|TPTE2P6_uc001upo.3_Non-coding_Transcript					Homo sapiens transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6 (TPTE2P6), non-coding RNA.																		TGAAACATCTCTACAACTGGA	0.343000													5	26					0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66500833	66500833	+	RNA	SNP	A	A	C			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr9:66500833A>C	uc004aed.1	+	2		c.926A>C								Homo sapiens uncharacterized LOC442421 (LOC442421), non-coding RNA.																		CCATGAAACCACCTGGTGCCC	0.632000													4	36					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	119013	119013	+	RNA	SNP	C	C	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chrGL000205.1:119013C>T	uc002kgk.4	+	0		c.2391C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		TGTACAGAGACGCGTCTCTCA	0.403000													3	3					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17556635	17556635	+	Missense_Mutation	SNP	T	T	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr6:17556635T>G	uc003ncb.3	+	12	1639	c.1396T>G	c.(1396-1398)Tcc>Gcc	p.S466A	CAP2_uc011dja.2_Missense_Mutation_p.S440A|CAP2_uc011djb.2_Missense_Mutation_p.S402A|CAP2_uc011djc.2_Missense_Mutation_p.S354A|CAP2_uc011djd.2_Missense_Mutation_p.S206A	NM_006366	NP_006357	P40123	CAP2_HUMAN	Homo sapiens CAP, adenylate cyclase-associated protein, 2 (yeast) (CAP2), mRNA.	466					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			ATGGGATGGATCCAAGTTAAT	0.403000													32	39					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160643	104160643	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr1:104160643C>A	uc001dut.3	+	1	300	c.236C>A	c.(235-237)cCa>cAa	p.P79Q	AMY2A_uc010ouq.1_Missense_Mutation_p.P79Q	NM_000699	NP_000690	P04746	AMYP_HUMAN	Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.	79					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AGATACCAACCAGTTAGCTAT	0.353000													23	231					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183041097	183041097	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:183041097C>A	uc003fli.1	-	5	619	c.529G>T	c.(529-531)Gac>Tac	p.D177Y	MCF2L2_uc003flj.1_Missense_Mutation_p.D177Y|MCF2L2_uc003flp.1_Missense_Mutation_p.D212Y	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Homo sapiens MCF.2 cell line derived transforming sequence-like 2 (MCF2L2), mRNA.	177	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGGCTTTTGTCGATGTAGCCG	0.423000													21	174					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446750	10446750	+	Missense_Mutation	SNP	T	T	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr4:10446750T>G	uc003gmn.3	-	2	1690	c.1203A>C	c.(1201-1203)gaA>gaC	p.E401D	ZNF518B_uc021xme.1_Missense_Mutation_p.E401D	NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	Homo sapiens zinc finger protein 518B (ZNF518B), mRNA.	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ACTTTGTTTTTTCTGCAGAAA	0.378000													8	151					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163099498	163099498	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr2:163099498C>G	uc002ucd.3	-	1	219	c.11G>C	c.(10-12)tGg>tCg	p.W4S	FAP_uc010zct.2_Missense_Mutation_p.W4S|FAP_uc010fpe.1_Missense_Mutation_p.W4S	NM_004460	NP_004451	Q12884	SEPR_HUMAN	Homo sapiens fibroblast activation protein, alpha (FAP), mRNA.	4					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GATTTTTACCCAAGTCTACAT	0.388000													4	11					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105260569	105260570	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr3:105260569_105260570insA	uc003dvx.3	+	7	1647_1648	c.951_952insA	c.(949-954)gacaaafs	p.D317fs	ALCAM_uc003dvw.2_Frame_Shift_Ins_p.D317fs|ALCAM_uc003dvy.3_Frame_Shift_Ins_p.D317fs|ALCAM_uc011bhh.1_Frame_Shift_Ins_p.D266fs|ALCAM_uc010hpp.3_Intron|ALCAM_uc003dvz.3_5'Flank	NM_001627	NP_001618	Q13740	CD166_HUMAN	Homo sapiens activated leukocyte cell adhesion molecule (ALCAM), transcript variant 1, mRNA.	317	Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CCCTGATAGACAAAAAAAGCAT	0.426													30	40	---	---	---	---					
ADCK2	90956	broad.mit.edu	37	7	140373825	140373825	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr7:140373825delT	uc003vvy.1	+	0	873	c.695delT	c.(694-696)cttfs	p.L232fs	ADCK2_uc003vvz.3_Frame_Shift_Del_p.L232fs	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	Homo sapiens aarF domain containing kinase 2 (ADCK2), mRNA.	232	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GTCCAGAGACTTGGCAGGGCC	0.582													40	119	---	---	---	---					
PLEKHG6	55200	broad.mit.edu	37	12	6436668	6436670	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:6436668_6436670delCTC	uc001qnr.3	+	14	2067_2069	c.1919_1921delCTC	c.(1918-1923)gctcct>gct	p.P641del	PLEKHG6_uc010sew.2_In_Frame_Del_p.P641del|PLEKHG6_uc010sex.2_In_Frame_Del_p.P609del	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 6 (PLEKHG6), transcript variant 1, mRNA.	641					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GACCCCCAAGCTCCTCAACGCCG	0.640													50	48	---	---	---	---					
SOX5	6660	broad.mit.edu	37	12	23699267	23699268	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:23699267_23699268insT	uc001rfw.3	-	11	1681_1682	c.1579_1580insA	c.(1579-1581)ctgfs	p.L527fs	SOX5_uc001rfx.3_Frame_Shift_Ins_p.L514fs|SOX5_uc001rfy.3_Frame_Shift_Ins_p.L406fs|SOX5_uc001rfv.3_Frame_Shift_Ins_p.L141fs|SOX5_uc010siv.2_Frame_Shift_Ins_p.L514fs|SOX5_uc010siw.1_Intron|SOX5_uc001rfz.1_Frame_Shift_Ins_p.L479fs	NM_006940	NP_694534	P35711	SOX5_HUMAN	Homo sapiens SRY (sex determining region Y)-box 5 (SOX5), transcript variant 1, mRNA.	527					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						ATCTCCACTCAGATTGAAATCC	0.337													33	43	---	---	---	---					
PARPBP	55010	broad.mit.edu	37	12	102590065	102590066	+	In_Frame_Ins	INS	-	-	ATA			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr12:102590065_102590066insATA	uc010swa.2	+	11	2079_2080	c.1967_1968insATA	c.(1966-1968)cta>ctATAa	p.657_658ins*	PARPBP_uc001tjf.3_In_Frame_Ins_p.580_581ins*|PARPBP_uc001tjg.3_In_Frame_Ins_p.499_500ins*|PARPBP_uc001tjh.3_In_Frame_Ins_p.499_500ins*|PARPBP_uc010swb.2_3'UTR|PARPBP_uc009zuc.3_In_Frame_Ins_p.134_135ins*|PARPBP_uc001tjj.3_In_Frame_Ins_p.295_296ins*|PARPBP_uc001tjk.3_3'UTR|PARPBP_uc009zud.3_3'UTR	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	Homo sapiens PARP1 binding protein (PARPBP), mRNA.	0					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						TTTTTTAGACTATAAATTTGTG	0.312													30	36	---	---	---	---					
COL4A1	1282	broad.mit.edu	37	13	110835578	110835578	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr13:110835578delG	uc001vqw.4	-	26	2065	c.1943delC	c.(1942-1944)cctfs	p.P648fs		NM_001845	NP_001836	P02462	CO4A1_HUMAN	Homo sapiens collagen, type IV, alpha 1 (COL4A1), mRNA.	648	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding	p.P647S(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TTCTGCTCCAGGGGGGCCTGG	0.527													2	4	---	---	---	---					
TCF25	22980	broad.mit.edu	37	16	89951019	89951020	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr16:89951019_89951020insA	uc002fpb.2	+	2	466_467	c.384_385insA	c.(382-387)aagaaafs	p.K128fs	TCF25_uc002fpc.2_5'UTR	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	Homo sapiens transcription factor 25 (basic helix-loop-helix) (TCF25), mRNA.	128					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TCCGGAAGAAGAAAAAAAAACA	0.446													11	97	---	---	---	---					
PTTG1IP	754	broad.mit.edu	37	21	46276194	46276196	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-N9-A4Q1-01A-11D-A28R-08	TCGA-N9-A4Q1-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f4b4c142-2d19-4ab4-92a4-ba0e6d8e8ed2	2a7a47d8-6e46-43e3-8262-9f7444070369	g.chr21:46276194_46276196delGCA	uc002zgb.2	-	3	648_650	c.361_363delTGC	c.(361-363)tgcdel	p.C121del	PTTG1IP_uc011afk.2_Intron	NM_004339	NP_004330	P53801	PTTG_HUMAN	Homo sapiens pituitary tumor-transforming 1 interacting protein (PTTG1IP), mRNA.	121	Poly-Cys.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TCTTCCTCCTGCAGCAGCAGCAG	0.616													7	134	---	---	---	---					
