Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRIML2	205860	broad.mit.edu	37	4	189022258	189022258	+	Silent	SNP	C	C	T	rs141580546	by1000genomes	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr4:189022258C>T	uc011cle.1	-	2	654	c.432G>A	c.(430-432)gcG>gcA	p.A144A	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc003izl.2_Silent_p.A94A|TRIML2_uc011clf.1_Silent_p.A144A	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	Homo sapiens tripartite motif family-like 2 (TRIML2), mRNA.	94							ligase activity	p.E143*(1)		central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CAAGCTTGATCGCTTGATTCA	0.433000													10	3					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228860403	228860403	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr2:228860403G>A	uc002vpq.2	-	7	4503	c.4456C>T	c.(4456-4458)Ctt>Ttt	p.L1486F	SPHKAP_uc002vpp.2_Missense_Mutation_p.L1486F|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	Homo sapiens SPHK1 interactor, AKAP domain containing (SPHKAP), transcript variant 1, mRNA.	1486						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGGTATCAAGGCTGTCACTG	0.532000													7	46					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	644395	644395	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr12:644395C>T	uc001qii.1	+	1	233	c.233C>T	c.(232-234)cCa>cTa	p.P78L		NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	Homo sapiens beta-1,4-N-acetyl-galactosaminyl transferase 3 (B4GALNT3), mRNA.	78						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GCTGTGGATCCACACCTCCAG	0.597000													6	29					0	0	1	0	0
XYLT2	64132	broad.mit.edu	37	17	48431783	48431783	+	Missense_Mutation	SNP	G	G	A	rs148860176	byFrequency	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:48431783G>A	uc002iqo.3	+	2	752	c.643G>A	c.(643-645)Ggc>Agc	p.G215S	XYLT2_uc010dbo.3_Non-coding_Transcript	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	Homo sapiens xylosyltransferase II (XYLT2), mRNA.	215					glycosaminoglycan biosynthetic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					GATGAGCCCCGGCATCCAGTG	0.667000													33	17					0	0	1	0	0
DHPS	1725	broad.mit.edu	37	19	12792434	12792434	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:12792434G>C	uc002muh.2	-	0	268	c.147C>G	c.(145-147)ttC>ttG	p.F49L	DHPS_uc002mug.2_5'Flank|DHPS_uc002mui.2_Missense_Mutation_p.F49L|DHPS_uc002muk.2_Non-coding_Transcript|DHPS_uc010xmn.2_Non-coding_Transcript	NM_001930	NP_001921	P49366	DHYS_HUMAN	Homo sapiens deoxyhypusine synthase (DHPS), transcript variant 1, mRNA.	49					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8					Sulfadoxine(DB01299)	CGGTGGTGCCGAAGGCCTCCA	0.632000													44	8					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr3:195505836G>C	uc021xjp.1	-	1	12771	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	9					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140801920	140801920	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:140801920G>A	uc003lkq.2	+	0	1384	c.1126G>A	c.(1126-1128)Gat>Aat	p.D376N	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljq.2_Intron|PCDHGC5_uc003ljs.2_Intron|PCDHGC5_uc003lju.2_Intron|PCDHGC5_uc003ljw.2_Intron|PCDHGC5_uc003ljy.2_Intron|PCDHGC5_uc003lka.2_Intron|PCDHGC5_uc003lkc.2_Intron|PCDHGC5_uc003lkd.2_Intron|PCDHGC5_uc003lkf.2_Intron|PCDHGC5_uc003lkh.2_Intron|PCDHGC5_uc003lkj.2_Intron|PCDHGC5_uc003lkl.2_Intron|PCDHGC5_uc003lkn.2_Intron|PCDHGC5_uc003lko.1_Missense_Mutation_p.D376N|PCDHGC5_uc003lkp.2_Missense_Mutation_p.D376N	NM_018914	NP_061737	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant 1, mRNA.	378	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D376H(1)		breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGATCAAGATTCTGGAGA	0.348000													5	37					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88937264	88937264	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:88937264C>A	uc004aou.3	-	13	3142	c.3004G>T	c.(3004-3006)Gat>Tat	p.D1002Y	ZCCHC6_uc010mqe.3_5'Flank|ZCCHC6_uc011ltf.2_Non-coding_Transcript|ZCCHC6_uc004aoq.3_Missense_Mutation_p.D1002Y|ZCCHC6_uc004aot.3_Intron|ZCCHC6_uc004aor.3_Non-coding_Transcript|ZCCHC6_uc004aos.3_Non-coding_Transcript	NM_001185059	NP_078893	Q5VYS8	TUT7_HUMAN	Homo sapiens zinc finger, CCHC domain containing 6 (ZCCHC6), transcript variant 2, mRNA.	1002					RNA 3'-end processing		RNA uridylyltransferase activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						CAGACTTGATCTAAGATATTT	0.343000													18	8					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207751246	207751246	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:207751246G>A	uc001hfy.3	+	20	3424	c.3284G>A	c.(3283-3285)tGc>tAc	p.C1095Y	CR1_uc009xcl.1_Missense_Mutation_p.C645Y|CR1_uc001hfx.3_Missense_Mutation_p.C1545Y|CR1_uc021pij.1_Missense_Mutation_p.C1095Y	NM_000573	NP_000564	P17927	CR1_HUMAN	Homo sapiens complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.	1095	Sushi 17.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACCTACCGCTGCAATCTTGGA	0.522000													8	223					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150067548	150067548	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:150067548G>A	uc003qmz.3	-	0	141	c.84C>T	c.(82-84)acC>acT	p.T28T	NUP43_uc011eef.1_Silent_p.T28T	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	Homo sapiens nucleoporin 43kDa (NUP43), transcript variant 1, mRNA.	28					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mRNA transport|mitotic prometaphase|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|condensed chromosome kinetochore|cytosol	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		ACGTCTCCGCGGTCTGTAAAC	0.587000											OREG0017720	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	94	130					0	0	1	0	0
CKM	1158	broad.mit.edu	37	19	45811690	45811690	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:45811690G>A	uc002pbd.3	-	5	927	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C		NM_001824	NP_001815	P06732	KCRM_HUMAN	Homo sapiens creatine kinase, muscle (CKM), mRNA.	252	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(3)|prostate(2)|skin(2)	17		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	ACGCAGAAGCGGCGGAAAACC	0.597000													11	46					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102506745	102506745	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:102506745G>A	uc001yks.2	+	62	12027	c.11863G>A	c.(11863-11865)Gag>Aag	p.E3955K		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA.	3955					G2/M transition of mitotic cell cycle|cytoplasmic mRNA processing body assembly|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	Golgi apparatus|centrosome|cytoplasmic dynein complex|cytosol|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TCAGGCAGACGAGGTGATTGT	0.512000													20	33					0	0	1	0	0
NBPF15	284565	broad.mit.edu	37	1	148594544	148594544	+	Silent	SNP	T	T	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:148594544T>C	uc001esb.2	+	21	3079	c.1917T>C	c.(1915-1917)caT>caC	p.H639H	NBPF15_uc001esc.2_Silent_p.H639H	NM_001170755	NP_775909	Q8N660	NBPFF_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 15 (NBPF15), transcript variant 1, mRNA.	639	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					AGGAAGAGCATATCAGCTTCG	0.433000													5	242					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14938184	14938184	+	Silent	SNP	A	A	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:14938184A>G	uc002mzw.3	-	0	1093	c.870T>C	c.(868-870)taT>taC	p.Y290Y	OR7A5_uc010xoa.2_Silent_p.Y290Y	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	Homo sapiens olfactory receptor, family 7, subfamily A, member 5 (OR7A5), mRNA.	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y290Y(4)		breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						TCCTCAGACTATAGATAAAGG	0.478000													4	91					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41467297	41467297	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:41467297G>A	uc003xnz.2	+	3	1298	c.359G>A	c.(358-360)cGg>cAg	p.R120Q		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (AGPAT6), mRNA.	120					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			TACTTTTGCCGGAAAGGAATG	0.443000													121	50					0	0	1	0	0
PPYR1	5540	broad.mit.edu	37	10	47087186	47087186	+	Missense_Mutation	SNP	G	G	A	rs144429123		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:47087186G>A	uc001jee.3	+	2	822	c.403G>A	c.(403-405)Gtg>Atg	p.V135M	ANXA8L1_uc001jed.4_Intron|PPYR1_uc009xna.3_Missense_Mutation_p.V135M|PPYR1_uc021ppu.1_Missense_Mutation_p.V135M	NM_005972	NP_005963	P50391	NPY4R_HUMAN	Homo sapiens pancreatic polypeptide receptor 1 (PPYR1), mRNA.	135					blood circulation|digestion|feeding behavior	integral to plasma membrane		p.V135M(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						GCTCGTCCTCGTGGCCCTGGA	0.572000													42	353					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57057477	57057477	+	Silent	SNP	C	C	T	rs140315231		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:57057477C>T	uc002iwx.3	+	6	1480	c.1353C>T	c.(1351-1353)tcC>tcT	p.S451S	PPM1E_uc010ddd.3_Silent_p.S214S	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E), mRNA.	460	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			AAGTTGTGTCCGACCACCTGA	0.502000													13	40					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7414885	7414885	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:7414885A>G	uc002ghf.4	+	23	4465	c.4079A>G	c.(4078-4080)aAt>aGt	p.N1360S		NM_000937	NP_000928	P24928	RPB1_HUMAN	Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (POLR2A), mRNA.	1360					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|RNA-directed RNA polymerase activity|metal ion binding|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ACCACGTCCAATGACATTGTG	0.592000													15	3					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:7577538C>T	uc002gim.2	-	6	937	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.3_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q|DL476309_uc021tpg.1_5'Flank|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(1145)|p.R248W(513)|p.R248L(145)|p.R248P(35)|p.R155Q(18)|p.R248G(12)|p.N247N(10)|p.R248R(10)|p.0?(8)|p.N247S(7)|p.N247D(5)|p.?(5)|p.N247_R248delNR(4)|p.M246_P250delMNRRP(4)|p.N247T(4)|p.N247I(3)|p.R155L(3)|p.N247Y(3)|p.R248fs*16(3)|p.N247_P250delNRRP(2)|p.N247_R248>KW(2)|p.R155P(2)|p.R248_P250delRRP(2)|p.N247_R249delNRR(2)|p.R248C(2)|p.R248fs*97(2)|p.N247_R248>IP(2)|p.N247K(2)|p.unknown(1)|p.R248fs*>39(1)|p.N247F(1)|p.R249fs*96(1)|p.R248Y(1)|p.G245fs*14(1)|p.N247fs*98(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	6					0	0	1	0	0
MTMR6	9107	broad.mit.edu	37	13	25848322	25848322	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:25848322C>T	uc001uqf.4	-	1	347	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K	MTMR6_uc001uqe.1_Missense_Mutation_p.E10K	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	Homo sapiens myotubularin related protein 6 (MTMR6), mRNA.	10						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTTACTTGTTCGACCTAAAAG	0.313000													22	8					0	0	1	0	0
ZNF654	55279	broad.mit.edu	37	3	88189976	88189976	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr3:88189976C>T	uc003dqv.3	+	0	1715	c.1516C>T	c.(1516-1518)Ccc>Tcc	p.P506S	CGGBP1_uc003dqu.3_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	Homo sapiens zinc finger protein 654 (ZNF654), mRNA.	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		ACCATTGCCTCCCAGTTACCT	0.393000													14	58					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76232491	76232491	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:76232491G>A	uc010ask.2	+	20	2112	c.1837G>A	c.(1837-1839)Gaa>Aaa	p.E613K	TTLL5_uc001xrx.3_Missense_Mutation_p.E599K|TTLL5_uc001xrz.3_Missense_Mutation_p.E174K|TTLL5_uc001xry.1_Non-coding_Transcript	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	Homo sapiens tubulin tyrosine ligase-like family, member 5 (TTLL5), mRNA.	599					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity	p.R612R(1)		NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGAAGATGAAGAACAGGAGGC	0.403000													12	19					0	0	1	0	0
DCXR	51181	broad.mit.edu	37	17	79994778	79994778	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:79994778G>A	uc002kdg.3	-	2	277	c.262C>T	c.(262-264)Ctg>Ttg	p.L88L	DCXR_uc021ufk.1_Silent_p.L86L	NM_016286	NP_057370	Q7Z4W1	DCXR_HUMAN	Homo sapiens dicarbonyl/L-xylulose reductase (DCXR), transcript variant 1, mRNA.	88					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	L-xylulose reductase (NADP+) activity|binding			kidney(1)|lung(3)	4	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGCTGCAGCAGGGCGACAGCG	0.687000													18	14					0	0	1	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23391160	23391160	+	Silent	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:23391160C>T	uc003swg.3	-	5	713	c.447G>A	c.(445-447)ttG>ttA	p.L149L		NM_006547	NP_006538	O00425	IF2B3_HUMAN	Homo sapiens insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), mRNA.	149	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						AGGCTACTTTCAAGGTGAAAT	0.527000													19	43					0	0	1	0	0
RPL3L	6123	broad.mit.edu	37	16	1995899	1995899	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr16:1995899G>A	uc002cnh.3	-	7	1031	c.984C>T	c.(982-984)aaC>aaT	p.N328N	TCRBV20S1_uc021tak.1_Intron|MSRB1_uc021tam.1_5'Flank	NM_005061	NP_005052	Q92901	RL3L_HUMAN	Homo sapiens ribosomal protein L3-like (RPL3L), mRNA.	328					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						TGACGAAGTCGTTGTTCACTT	0.612000													22	43					0	0	1	0	0
BC080605	0	broad.mit.edu	37	9	68414799	68414799	+	RNA	SNP	A	A	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:68414799A>G	uc004aex.3	+	0		c.1354A>G								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		gcatggtggtagtacctgtaa	0.493000													3	19					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131600040	131600040	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:131600040G>A	uc004bwh.3	-	5	676	c.491C>T	c.(490-492)cCc>cTc	p.P164L	CCBL1_uc004bwg.3_Non-coding_Transcript|CCBL1_uc010myn.3_Missense_Mutation_p.P164L|CCBL1_uc004bwj.3_Missense_Mutation_p.P114L|CCBL1_uc004bwi.3_Non-coding_Transcript|CCBL1_uc011mbl.2_Missense_Mutation_p.P258L	NM_004059	NP_004050	Q16773	KAT1_HUMAN	Homo sapiens cysteine conjugate-beta lyase, cytoplasmic (CCBL1), transcript variant 1, mRNA.	164					L-phenylalanine catabolic process|kynurenine metabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CAGCTCCATGGGGTCCAGCTG	0.597000													46	6					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61585320	61585320	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr18:61585320C>T	uc010xev.2	+	3	446	c.356C>T	c.(355-357)aCg>aTg	p.T119M	SERPINB2_uc010xew.2_Missense_Mutation_p.T119M	NM_005024	NP_005015	P05120	PAI2_HUMAN	Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 10 (SERPINB10), mRNA.	134					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	Golgi apparatus|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.T119M(1)		NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	GGAGAGAAAACGTATGCATTT	0.348000													14	5					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19493718	19493718	+	Missense_Mutation	SNP	C	C	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:19493718C>G	uc001bbi.3	-	28	3911	c.3907G>C	c.(3907-3909)Gat>Cat	p.D1303H	UBR4_uc001bbm.1_Missense_Mutation_p.D514H	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA.	1303					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCATCTCATCTGACCAACTT	0.458000													20	26					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20483158	20483158	+	Silent	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr14:20483158C>T	uc010tky.2	-	0	195	c.195G>A	c.(193-195)ggG>ggA	p.G65G		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily K, member 14 (OR4K14), mRNA.	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L64L(1)		breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AAGCTAGGTTCCCCAGCAGGA	0.483000													15	59					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83855292	83855292	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:83855292G>A	uc011dyy.2	+	24	5824	c.5564G>A	c.(5563-5565)cGt>cAt	p.R1855H	DOPEY1_uc003pjs.1_Missense_Mutation_p.R1864H|DOPEY1_uc010kbl.1_Missense_Mutation_p.R1855H|DOPEY1_uc003pjt.3_Non-coding_Transcript	NM_001199942	NP_001186871	Q5JWR5	DOP1_HUMAN	Homo sapiens dopey family member 1 (DOPEY1), transcript variant 2, mRNA.	1864					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GAATTGGTTCGTTCAATCAGT	0.373000													7	12					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832426	42832426	+	RNA	SNP	T	T	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:42832426T>C	uc010qey.2	-	2		c.1549A>G								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		AATTCTCTTGTGTATAGTAAG	0.373000													3	16					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685017	248685017	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:248685017G>A	uc001ien.1	+	0	70	c.70G>A	c.(70-72)Gag>Aag	p.E24K		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily G, member 6 (OR2G6), mRNA.	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTCAGCTAGAGAGGTTTCT	0.463000													53	45					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114483989	114483989	+	Silent	SNP	C	C	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:114483989C>A	uc001eem.3	+	1	1145	c.984C>A	c.(982-984)cgC>cgA	p.R328R	HIPK1_uc001eel.3_Silent_p.R328R|HIPK1_uc001een.3_Silent_p.R328R	NM_198268	NP_938010	Q86Z02	HIPK1_HUMAN	Homo sapiens homeodomain interacting protein kinase 1 (HIPK1), transcript variant 1, mRNA.	328	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCCAGTTCGCCAGCCCTACC	0.502000													21	100					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31322991	31322991	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:31322991G>A	uc003nth.2	-	4	959	c.905C>T	c.(904-906)tCc>tTc	p.S302F	HLA-C_uc003ntf.2_Intron|HLA-C_uc003ntg.1_Missense_Mutation_p.S181F|HLA-C_uc003nti.1_Intron	NM_005514	NP_005505	Q9TNN7	1C05_HUMAN	Homo sapiens major histocompatibility complex, class I, B (HLA-B), mRNA.	302	Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						GGTGGACTGGGAAGACGGCTC	0.597000													22	51					0	0	1	0	0
DUSP22	56940	broad.mit.edu	37	6	350858	350858	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:350858G>C	uc003msx.3	+	7	984	c.545G>C	c.(544-546)aGa>aCa	p.R182T	DUSP22_uc003msy.1_3'UTR	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	Homo sapiens dual specificity phosphatase 22 (DUSP22), mRNA.	182					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GCCTTTCTCAGAAGACTGTAA	0.393000													11	37					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112364641	112364641	+	Missense_Mutation	SNP	G	G	A	rs145982424		TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:112364641G>A	uc003kql.4	-	17	3285	c.2869C>T	c.(2869-2871)Cgg>Tgg	p.R957W	MCC_uc003kqj.4_Missense_Mutation_p.R767W|MCC_uc003kqk.4_Non-coding_Transcript	NM_001085377	NP_001078846	P23508	CRCM_HUMAN	Homo sapiens mutated in colorectal cancers (MCC), transcript variant 1, mRNA.	767					Wnt receptor signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTGTTGGCCCGCTTTAGATCA	0.537000													12	175					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99696031	99696031	+	Missense_Mutation	SNP	G	G	A	rs80014629	byFrequency	TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:99696031G>A	uc001kou.2	-	2	673	c.317C>T	c.(316-318)gCg>gTg	p.A106V	CRTAC1_uc001kov.3_Missense_Mutation_p.A106V|CRTAC1_uc001kot.2_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	Homo sapiens cartilage acidic protein 1 (CRTAC1), transcript variant 1, mRNA.	106						proteinaceous extracellular matrix	calcium ion binding	p.A106V(2)|p.A106T(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GTCCCGCAGCGCGTAGTAGGG	0.617000													28	44					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19316786	19316786	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:19316786G>A	uc003znq.3	+	7	1128	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	DENND4C_uc011lnc.2_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	Homo sapiens DENN/MADD domain containing 4C (DENND4C), mRNA.	350	dDENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ACCAATCACAGAGGCTCCTTC	0.373000													44	15					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2411210	2411210	+	Missense_Mutation	SNP	G	G	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr20:2411210G>T	uc002wfy.1	+	10	1858	c.1797G>T	c.(1795-1797)gaG>gaT	p.E599D	TGM6_uc010gal.1_Missense_Mutation_p.E599D	NM_198994	NP_945345	O95932	TGM3L_HUMAN	Homo sapiens transglutaminase 6 (TGM6), transcript variant 1, mRNA.	599					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TTCTGGTGGAGAAGGACATTA	0.502000													24	23					0	0	1	0	0
SUMF2	25870	broad.mit.edu	37	7	56140699	56140699	+	Silent	SNP	C	C	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:56140699C>G	uc011kcw.2	+	2	322	c.291C>G	c.(289-291)gtC>gtG	p.V97V	PSPH_uc003trj.3_Intron|SUMF2_uc011kcv.2_Non-coding_Transcript|SUMF2_uc003trt.3_5'UTR|SUMF2_uc003trv.3_Silent_p.V97V|SUMF2_uc011kcy.2_Silent_p.V97V|SUMF2_uc011kcz.2_Silent_p.V97V|SUMF2_uc003trx.3_Non-coding_Transcript|SUMF2_uc011kda.2_Intron|SUMF2_uc011kcx.2_Silent_p.V97V	NM_015411	NP_001139805	Q8NBJ7	SUMF2_HUMAN	Homo sapiens sulfatase modifying factor 2 (SUMF2), transcript variant 2, mRNA.	78						endoplasmic reticulum lumen	metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	14	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGGATTTTGTCAGGGAGAAAA	0.478000													10	25					0	0	1	0	0
NCK1	4690	broad.mit.edu	37	3	136664877	136664877	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr3:136664877C>T	uc003erh.3	+	2	809	c.679C>T	c.(679-681)Cca>Tca	p.P227S	NCK1_uc011bme.2_Missense_Mutation_p.P163S	NM_006153	NP_006144	P16333	NCK1_HUMAN	Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA.	227	SH3 3.				T cell activation|T cell receptor signaling pathway|axon guidance|positive regulation of T cell proliferation|positive regulation of actin filament polymerization|regulation of translation|signal complex assembly	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						TGAAAATGACCCAGAGTGGTG	0.378000													47	47					0	0	1	0	0
BC080605	0	broad.mit.edu	37	9	68414330	68414330	+	RNA	SNP	T	T	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:68414330T>C	uc004aex.3	+	0		c.885T>C								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		atgattaagcttagtgaagat	0.428000													3	24					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916917	149916917	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:149916917C>A	uc001etn.3	-	11	1727	c.1371G>T	c.(1369-1371)gaG>gaT	p.E457D		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	Homo sapiens OTU domain containing 7B (OTUD7B), mRNA.	457					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|cysteine-type peptidase activity|protein binding|zinc ion binding	p.D456H(1)|p.E457G(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TGGACCGGGGCTCATCTCCAG	0.622000													28	45					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3614997	3614997	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr20:3614997G>C	uc002wim.2	+	25	3993	c.3903G>C	c.(3901-3903)tgG>tgC	p.W1301C		NM_139321	NP_647537	O75882	ATRN_HUMAN	Homo sapiens attractin (ATRN), transcript variant 1, mRNA.	1301					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTGGTTTGGAAGATCAAAC	0.458000													11	66					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198855	91198855	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:91198855G>A	uc001kgm.3	-	5	835	c.534C>T	c.(532-534)atC>atT	p.I178I	SLC16A12_uc001kgl.3_5'Flank	NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	Homo sapiens solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (SLC16A12), mRNA.	148						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						CTGACATGGCGATACCATAAG	0.498000													20	140					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940732	144940732	+	Silent	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:144940732C>T	uc003zaa.1	-	0	6703	c.6690G>A	c.(6688-6690)ctG>ctA	p.L2230L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	Homo sapiens epiplakin 1 (EPPK1), mRNA.	2230						cytoplasm|cytoskeleton	protein binding|structural molecule activity	p.L2230L(2)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCGGGCACCAGGACGCCCG	0.687000													6	151					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151238	139151238	+	Missense_Mutation	SNP	G	G	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr8:139151238G>T	uc003yuy.3	-	17	4063	c.3892C>A	c.(3892-3894)Caa>Aaa	p.Q1298K	FAM135B_uc003yux.3_Missense_Mutation_p.Q1199K|FAM135B_uc003yuz.3_Non-coding_Transcript	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	Homo sapiens family with sequence similarity 135, member B (FAM135B), mRNA.	1298								p.S1297I(1)|p.S1297C(1)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTGTTTTTTGGCTTAGTTGG	0.438000										HNSCC(54;0.14)			16	22					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36051399	36051399	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:36051399G>A	uc002oal.1	-	5	682	c.653C>T	c.(652-654)gCg>gTg	p.A218V	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	Homo sapiens ATPase, H+/K+ exchanging, alpha polypeptide (ATP4A), mRNA.	218					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding	p.A218V(2)		breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCCCTGGGCCGCCAGGATGCG	0.637000													57	100					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52715983	52715983	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:52715983G>A	uc002pyp.3	+	4	843	c.548G>A	c.(547-549)cGg>cAg	p.R183Q	PPP2R1A_uc010ydk.2_Missense_Mutation_p.R128Q|PPP2R1A_uc010epm.1_Missense_Mutation_p.R223Q|PPP2R1A_uc002pyq.3_Missense_Mutation_p.R4Q	NM_014225	NP_055040	P30153	2AAA_HUMAN	Homo sapiens protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant 1, mRNA.	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				G2/M transition of mitotic cell cycle|RNA splicing|ceramide metabolic process|chromosome segregation|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of DNA replication|regulation of Wnt receptor signaling pathway|regulation of cell adhesion|regulation of cell differentiation|regulation of transcription, DNA-dependent|response to organic substance|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183W(22)|p.R183Q(20)|p.R182W(5)|p.R183G(2)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATGGTGCGGCGGGCCGCAGCC	0.617000			Mis		clear cell ovarian carcinoma								92	12					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89730615	89730615	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:89730615G>A	uc001dnc.3	-	7	1440	c.903C>T	c.(901-903)gcC>gcT	p.A301A	GBP5_uc001dnd.3_Silent_p.A301A|GBP5_uc001dne.1_Silent_p.A301A	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	Homo sapiens guanylate binding protein 5 (GBP5), transcript variant 1, mRNA.	301						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CACTGCTGATGGCATTGACAT	0.443000													23	42					0	0	1	0	0
FLJ43315	644316	broad.mit.edu	37	GL000211.1	91868	91868	+	RNA	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chrGL000211.1:91868G>A	uc003bnz.1	+	6		c.1224G>A			FLJ43315_uc003boa.3_Non-coding_Transcript					Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding RNA.																		AGATACATAAGGAGTCAGACC	0.348000													3	10					0	0	1	0	0
NOSIP	51070	broad.mit.edu	37	19	50062164	50062164	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:50062164C>T	uc002pok.3	-	4	400	c.248G>A	c.(247-249)cGg>cAg	p.R83Q	NOSIP_uc002pol.3_Missense_Mutation_p.R83Q|NOSIP_uc010yay.1_Non-coding_Transcript	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	Homo sapiens nitric oxide synthase interacting protein (NOSIP), mRNA.	83					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		CTTCATCTGCCGGGCAATCTC	0.562000													15	428					0	0	1	0	0
HIST1H2BF	8343	broad.mit.edu	37	6	26200068	26200068	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr6:26200068G>A	uc003ngx.3	+	0	282	c.282G>A	c.(280-282)gaG>gaA	p.E94E	HIST1H3D_uc003ngv.3_5'Flank|HIST1H3D_uc021ymt.1_5'Flank|HIST1H2AD_uc003ngw.3_5'Flank	NM_003522	NP_003517	P62807	H2B1C_HUMAN	Homo sapiens histone cluster 1, H2bf (HIST1H2BF), mRNA.	94					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(7)|upper_aerodigestive_tract(3)	17		all_hematologic(11;0.196)				CCTCCAGGGAGATCCAGACGG	0.602000													69	120					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77792029	77792029	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:77792029G>C	uc021rks.1	-	20	3270	c.3003C>G	c.(3001-3003)aaC>aaG	p.N1001K	MYCBP2_uc010aev.3_Missense_Mutation_p.N367K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	Homo sapiens MYC binding protein 2 (MYCBP2), mRNA.	963					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGCCGTATGGTTGCTGCCTG	0.378000													25	86					0	0	1	0	0
ZNF781	163115	broad.mit.edu	37	19	38160916	38160916	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:38160916C>T	uc002ogy.2	-	3	876	c.134G>A	c.(133-135)cGt>cAt	p.R45H	ZNF781_uc002ogz.2_Missense_Mutation_p.R40H|ZNF781_uc021utu.1_Missense_Mutation_p.R45H	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	Homo sapiens zinc finger protein 781 (ZNF781), mRNA.	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						AAGGTGGGCACGCTTTCTAAA	0.383000													127	98					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226827357	226827357	+	Silent	SNP	T	T	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr1:226827357T>C	uc010pvo.2	-	5	2794	c.2454A>G	c.(2452-2454)aaA>aaG	p.K818K		NM_002221	NP_002212	P27987	IP3KB_HUMAN	Homo sapiens inositol-trisphosphate 3-kinase B (ITPKB), mRNA.	818							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TGCCGTCTTCTTTCTGAGAAA	0.567000													18	37					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75653473	75653473	+	Silent	SNP	G	G	C			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr15:75653473G>C	uc002bah.3	-	11	1391	c.1374C>G	c.(1372-1374)ctC>ctG	p.L458L	MAN2C1_uc010bkk.3_Silent_p.L359L|MAN2C1_uc002baf.3_Silent_p.L458L|MAN2C1_uc002bag.3_Silent_p.L458L|MAN2C1_uc010umi.1_Silent_p.L240L			Q9NTJ4	MA2C1_HUMAN	Homo sapiens mannosidase, alpha, class 2C, member 1 (MAN2C1), mRNA.	458					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CAAAGCCAAAGAGGAAGGCAC	0.647000													12	3					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881650	26881650	+	Silent	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:26881650G>A	uc003jgs.1	-	11	2134	c.1965C>T	c.(1963-1965)aaC>aaT	p.N655N	CDH9_uc011cnv.1_Silent_p.N248N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	Homo sapiens cadherin 9, type 2 (T1-cadherin) (CDH9), mRNA.	655					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						AGGTCACAATGTTGTCCCGGA	0.413000													31	93					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47961709	47961709	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr21:47961709C>A	uc002zjo.2	+	17	2260	c.2077C>A	c.(2077-2079)Ctg>Atg	p.L693M	DIP2A_uc011afy.1_Missense_Mutation_p.L629M|DIP2A_uc011afz.1_Missense_Mutation_p.L689M|DIP2A_uc002zjl.3_Missense_Mutation_p.L693M|DIP2A_uc002zjm.3_Missense_Mutation_p.L693M|DIP2A_uc010gql.3_Missense_Mutation_p.L650M|DIP2A_uc002zjn.3_Missense_Mutation_p.L693M|DIP2A_uc002zjp.1_Missense_Mutation_p.L438M|DIP2A_uc002zjq.3_Missense_Mutation_p.L85M	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	Homo sapiens DIP2 disco-interacting protein 2 homolog A (Drosophila) (DIP2A), transcript variant 1, mRNA.	693					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		AAAAGCAGTCCTGTCGATGAA	0.488000													19	31					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39133037	39133037	+	Missense_Mutation	SNP	C	C	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:39133037C>G	uc004abi.3	-	12	2211	c.1972G>C	c.(1972-1974)Gcg>Ccg	p.A658P	CNTNAP3_uc004abj.3_Missense_Mutation_p.A657P|CNTNAP3_uc011lqr.2_Non-coding_Transcript|CNTNAP3_uc004abk.1_Missense_Mutation_p.A658P|CNTNAP3_uc011lqs.1_Missense_Mutation_p.A564P	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	Homo sapiens contactin associated protein-like 3 (CNTNAP3), mRNA.	658	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCTGCGTACGCGAAGGACACA	0.776000													3	6					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36832073	36832073	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr19:36832073G>A	uc010xtd.2	-	3	737	c.658C>T	c.(658-660)Cac>Tac	p.H220Y	ZFP14_uc010eex.2_Missense_Mutation_p.H219Y	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	Homo sapiens zinc finger protein 14 homolog (mouse) (ZFP14), mRNA.	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TGAAGTTTGTGATGTCGAATA	0.443000													30	144					0	0	1	0	0
BC080605	0	broad.mit.edu	37	9	68413654	68413654	+	RNA	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:68413654G>A	uc004aex.3	+	0		c.209G>A								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		GAGTGCAGACGAGAGCCCCGG	0.642000													3	16					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62942335	62942335	+	Missense_Mutation	SNP	G	G	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr15:62942335G>T	uc002alb.4	+	1	189	c.189G>T	c.(187-189)tgG>tgT	p.W63C		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	Homo sapiens talin 2 (TLN2), mRNA.	63					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AAGGGATTTGGCTGGAAGCGG	0.478000													40	6					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5352339	5352339	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr7:5352339G>A	uc003soi.4	-	26	8532	c.8183C>T	c.(8182-8184)gCg>gTg	p.A2728V		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	Homo sapiens trinucleotide repeat containing 18 (TNRC18), mRNA.	2728							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGGAGGAGGCGCCTGGGGCTG	0.736000													6	15					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832431	42832431	+	RNA	SNP	A	A	G			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr10:42832431A>G	uc010qey.2	-	2		c.1544T>C								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		TCTTGTGTATAGTAAGGTTTG	0.373000													3	18					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103710664	103710664	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr13:103710664G>A	uc001vpy.4	-	1	1043	c.446C>T	c.(445-447)aCc>aTc	p.T149I		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	Homo sapiens solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (SLC10A2), mRNA.	149					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CCACATTTTGGTATAGATAAG	0.483000													13	75					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116572463	116572463	+	Missense_Mutation	SNP	T	T	A			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr2:116572463T>A	uc002tle.3	+	19	1828	c.1807T>A	c.(1807-1809)Ttt>Att	p.F603I	DPP10_uc002tla.2_Missense_Mutation_p.F599I|DPP10_uc002tlb.2_Missense_Mutation_p.F549I|DPP10_uc002tlc.2_Missense_Mutation_p.F595I|DPP10_uc002tlf.2_Missense_Mutation_p.F592I	NM_001178034	NP_001171505	Q8N608	DPP10_HUMAN	Homo sapiens dipeptidyl-peptidase 10 (non-functional) (DPP10), transcript variant 3, mRNA.	599					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity	p.L602L(1)|p.F592I(1)|p.F599I(1)		breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TGTAGCAAGATTTGATGGCAG	0.423000													33	117					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103109336	103109336	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr9:103109336C>T	uc004bas.3	-	2	748	c.533G>A	c.(532-534)cGt>cAt	p.R178H	TEX10_uc011lvf.2_Intron|TEX10_uc011lvg.2_Missense_Mutation_p.R181H|TEX10_uc011lvh.1_Missense_Mutation_p.R113H	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	Homo sapiens testis expressed 10 (TEX10), transcript variant 1, mRNA.	178						MLL1 complex|integral to membrane|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TATGCTGCTACGGCCAGTAAT	0.413000													18	9					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32407014	32407015	+	In_Frame_Ins	INS	-	-	GCA			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr5:32407014_32407015insGCA	uc003jhr.1	-	5	976_977	c.896_897insTGC	c.(895-897)gca>gcTGCa	p.299_299A>AA	ZFR_uc010iun.1_In_Frame_Ins_p.299_299A>AA	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	Homo sapiens zinc finger RNA binding protein (ZFR), mRNA.	299	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGGCAgctgttgcagcagcagc	0.480													8	53	---	---	---	---					
ARCN1	372	broad.mit.edu	37	11	118454048	118454050	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr11:118454048_118454050delAGA	uc009zag.3	+	3	747_749	c.545_547delAGA	c.(544-549)gagaag>gag	p.K183del	ARCN1_uc001ptq.3_In_Frame_Del_p.K142del|ARCN1_uc010ryg.2_In_Frame_Del_p.K54del	NM_001142281	NP_001135753	P48444	COPD_HUMAN	Homo sapiens archain 1 (ARCN1), transcript variant 2, mRNA.	142					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|clathrin adaptor complex|cytosol				endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|urinary_tract(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TCTCATGAGGAGAAGGTGTTCAG	0.404													17	25	---	---	---	---					
FAM20A	54757	broad.mit.edu	37	17	66538939	66538955	+	Splice_Site	DEL	AAGTCCAGAATCCTGCA	AAGTCCAGAATCCTGCA	-			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr17:66538939_66538955delAAGTCCAGAATCCTGCA	uc002jho.3	-	6	1101	c.813_splice	c.e6-1	p.R271_splice	FAM20A_uc010wqp.2_Splice_Site_p.R133_splice|FAM20A_uc002jhn.3_Splice_Site	NM_017565	NP_001230675	Q96MK3	FA20A_HUMAN	Homo sapiens family with sequence similarity 20, member A (FAM20A), transcript variant 1, mRNA.	271						extracellular region				cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(1)	9	Breast(10;1.64e-13)					CACCCGTCGGAAGTCCAGAATCCTGCAAGAGAGGAAG	0.521													30	45	---	---	---	---					
TXN2	25828	broad.mit.edu	37	22	36872876	36872876	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NA-A4QW-01A-11D-A28R-08	TCGA-NA-A4QW-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c486c36-01d0-4ff7-9478-19b0104898b1	c0493785-cc4a-4a03-bc34-0e14e890571b	g.chr22:36872876delC	uc003apk.1	-	2	368	c.291delG	c.(289-291)gggfs	p.G97fs	TXN2_uc003apl.1_Non-coding_Transcript	NM_012473	NP_036605	Q99757	THIOM_HUMAN	Homo sapiens thioredoxin 2 (TXN2), nuclear gene encoding mitochondrial protein, mRNA.	97	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity			breast(1)|lung(1)|prostate(1)	3						CTAACCTCGGCCCCAGGATCT	0.547													58	146	---	---	---	---					
