Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SPEN	23013	broad.mit.edu	37	1	16203019	16203019	+	Silent	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:16203019C>A	uc001axk.1	+	3	931	c.727C>A	c.(727-729)CGG>AGG	p.R243R	SPEN_uc010obp.1_Silent_p.R202R	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	243	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CAGCAGGAGTCGGTCACCACA	0.547000													27	55					8.24728e-16	9.5959e-16	1	0
AIM1L	55057	broad.mit.edu	37	1	26672990	26672990	+	5'Flank	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:26672990C>T	uc001bmd.3	-						uc009vsi.1_Silent_p.E53E	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACTCAAACATCTCCTTCTGCG	0.567000													7	24					0	0	0	0
SLC9A1	6548	broad.mit.edu	37	1	27427043	27427043	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:27427043C>A	uc001bnm.2	-	12	2829	c.2203G>T	c.(2203-2205)GAA>TAA	p.E735*	SLC9A1_uc001bnl.2_Nonsense_Mutation_p.E239*|SLC9A1_uc010ofk.1_Nonsense_Mutation_p.E396*	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	735	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TTCAGCTCTTCATTCACCAGG	0.607000													111	325					5.55186e-77	6.8473e-77	1	0
LCK	3932	broad.mit.edu	37	1	32739961	32739961	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32739961G>A	uc001bux.2	+	2	169	c.31G>A	c.(31-33)GAT>AAT	p.D11N	LCK_uc001buy.2_Missense_Mutation_p.D11N|LCK_uc001buz.2_Missense_Mutation_p.D11N|LCK_uc010ohc.1_Missense_Mutation_p.D55N|LCK_uc001bva.2_Missense_Mutation_p.D11N	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	11	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	ACACCCGGAAGATGACTGGAT	0.567000			T	TRB@	T-ALL								11	83					0	0	0	0
LCK	3932	broad.mit.edu	37	1	32740021	32740021	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32740021G>T	uc001bux.2	+	2	229	c.91G>T	c.(91-93)GAT>TAT	p.D31Y	LCK_uc001buy.2_Missense_Mutation_p.D31Y|LCK_uc001buz.2_Missense_Mutation_p.D31Y|LCK_uc010ohc.1_Missense_Mutation_p.D75Y|LCK_uc001bva.2_Missense_Mutation_p.D31Y	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	31	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGTCCCACTGGATGGCAAGGG	0.552000			T	TRB@	T-ALL								9	72					1.76689e-08	1.98106e-08	1	0
LCK	3932	broad.mit.edu	37	1	32745441	32745441	+	Splice_Site	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32745441G>A	uc001bux.2	+	11	1180	c.1042_splice	c.e11-1	p.I348_splice	LCK_uc001buy.2_Splice_Site_p.I348_splice|LCK_uc001buz.2_Splice_Site_p.I378_splice|LCK_uc010ohc.1_Splice_Site_p.I392_splice|LCK_uc001bva.2_Splice_Site_p.I355_splice	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase						activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TTGGCCTGCAGATTGCAGAAG	0.542000			T	TRB@	T-ALL								20	142					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44058140	44058140	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:44058140T>C	uc001cjr.2	+	11	2021	c.1681T>C	c.(1681-1683)TTC>CTC	p.F561L	PTPRF_uc001cjs.2_Missense_Mutation_p.F561L|PTPRF_uc001cju.2_Missense_Mutation_p.F132L|PTPRF_uc009vwt.2_Missense_Mutation_p.F132L|PTPRF_uc001cjv.2_Missense_Mutation_p.F132L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	561	Extracellular (Potential).|Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CAAGGTGACCTTCGACCCAAC	0.572000													50	164					0	0	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510090	77510090	+	Missense_Mutation	SNP	A	G	G	rs34735755		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:77510090A>G	uc001dhi.2	+	3	638	c.463A>G	c.(463-465)AAC>GAC	p.N155D	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	155	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						GATCCTCCGCAACCGCCATGA	0.637000													15	58					0	0	0	0
BCAR3	8412	broad.mit.edu	37	1	94037258	94037258	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:94037258G>C	uc001dpz.2	-	9	2218	c.1943C>G	c.(1942-1944)TCA>TGA	p.S648*	BCAR3_uc001dqa.2_Nonsense_Mutation_p.S648*|BCAR3_uc001dqb.2_Nonsense_Mutation_p.S648*|BCAR3_uc001dpx.3_Nonsense_Mutation_p.S324*|BCAR3_uc001dpy.2_Nonsense_Mutation_p.S557*|BCAR3_uc009wdm.1_Nonsense_Mutation_p.S324*	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	648	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CATGAGAGCTGAGAAGGAATA	0.478000													25	128					0	0	0	0
OLFM3	118427	broad.mit.edu	37	1	102270141	102270141	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:102270141G>A	uc001duf.2	-	6	1161	c.1090C>T	c.(1090-1092)CAG>TAG	p.Q364*	OLFM3_uc001dug.2_Nonsense_Mutation_p.Q344*|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Nonsense_Mutation_p.Q269*|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	364	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CCTGCATTCTGGTTAGTTGCA	0.483000													11	68					0	0	0	0
WDR47	22911	broad.mit.edu	37	1	109554265	109554265	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:109554265T>C	uc001dwj.2	-	5	779	c.403A>G	c.(403-405)AGT>GGT	p.S135G	WDR47_uc001dwl.2_Missense_Mutation_p.S142G|WDR47_uc001dwi.2_Missense_Mutation_p.S135G|WDR47_uc001dwk.2_Missense_Mutation_p.S107G|WDR47_uc010ovf.1_Missense_Mutation_p.S62G	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	135										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CAGAGCTTACTATAGTCATCT	0.408000													44	180					0	0	0	0
LOC100286793	100286793	broad.mit.edu	37	1	143744418	143744418	+	RNA	SNP	C	T	T	rs71661951		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:143744418C>T	uc001ejp.3	-	1		c.170G>A			LOC100286793_uc001ejr.3_RNA|LOC100286793_uc009whx.2_RNA|LOC100286793_uc009why.2_RNA					Homo sapiens cDNA FLJ39739 fis, clone SMINT2016440.												0						CAAGTGGTTTCGGAAGTGATC	0.403000													3	8					0	0	0	0
MRPL9	65005	broad.mit.edu	37	1	151734860	151734860	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:151734860C>A	uc001eyv.2	-	3	512	c.427G>T	c.(427-429)GAG>TAG	p.E143*	MRPL9_uc009wmz.2_RNA|MRPL9_uc010pdk.1_Nonsense_Mutation_p.E143*|MRPL9_uc009wna.1_3'UTR	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	143					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACCAATTTCTCCTCTTCAAAC	0.438000													40	158					3.43241e-23	4.17761e-23	1	0
OR10T2	128360	broad.mit.edu	37	1	158368589	158368589	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:158368589A>G	uc010pih.1	-	1	668	c.668T>C	c.(667-669)GTT>GCT	p.V223A		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GATGGTGTTAACTATGAAGCC	0.473000													7	47					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171506560	171506560	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:171506560G>C	uc010pmg.1	+	15	2712	c.2446G>C	c.(2446-2448)GAG>CAG	p.E816Q	BAT2L2_uc010pmh.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	816							protein C-terminus binding				0						TCCTCATGCTGAGCCTCAACA	0.408000													2	8					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564125	176564125	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:176564125C>T	uc001gkz.2	+	3	2549	c.1385C>T	c.(1384-1386)CCT>CTT	p.P462L	PAPPA2_uc001gky.1_Missense_Mutation_p.P462L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	462	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGCTTTGAGCCTGTGAACACA	0.542000													24	111					0	0	0	0
HMCN1	83872	broad.mit.edu	37	1	186039757	186039757	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:186039757C>T	uc001grq.1	+	52	8236	c.8007C>T	c.(8005-8007)ATC>ATT	p.I2669I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2669	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CACCCATAATCAATAAAGGGG	0.373000													25	110					0	0	0	0
KDM5B	10765	broad.mit.edu	37	1	202724420	202724420	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:202724420T>A	uc001gyf.2	-	11	1633	c.1517A>T	c.(1516-1518)TAT>TTT	p.Y506F	KDM5B_uc009xag.2_Missense_Mutation_p.Y542F|KDM5B_uc001gyg.1_Missense_Mutation_p.Y348F	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	506	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GTTAATTGAATAGCTCCAGTG	0.403000													32	92					0	0	0	0
TLR5	7100	broad.mit.edu	37	1	223284063	223284063	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:223284063C>T	uc001hnv.1	-	4	2757	c.2311G>A	c.(2311-2313)GCC>ACC	p.A771T	TLR5_uc001hnw.1_Missense_Mutation_p.A771T	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	771	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TAACTGAAGGCTTCAAGGCAC	0.483000													11	45					0	0	0	0
EXOC8	149371	broad.mit.edu	37	1	231472440	231472440	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:231472440C>T	uc001huq.2	-	1	1139	c.1052G>A	c.(1051-1053)AGA>AAA	p.R351K		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	351					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TTCAAAGTCTCTCTGCGCAAT	0.498000													28	132					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240493979	240493979	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:240493979A>T	uc010pyd.1	+	11	4739	c.4514A>T	c.(4513-4515)AAT>ATT	p.N1505I	FMN2_uc010pye.1_Missense_Mutation_p.N1509I|FMN2_uc010pyf.1_Missense_Mutation_p.N151I|FMN2_uc010pyg.1_Missense_Mutation_p.N101I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1505	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AATGGAGGAAATAAGACTCGA	0.403000													29	93					0	0	0	0
NMT2	9397	broad.mit.edu	37	10	15175327	15175327	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:15175327C>G	uc001inz.1	-	4	511	c.427G>C	c.(427-429)GAT>CAT	p.D143H	NMT2_uc001ioa.1_Missense_Mutation_p.D130H|NMT2_uc009xjo.1_Missense_Mutation_p.D143H|NMT2_uc010qbz.1_5'UTR	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	143					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TTGTCTTTATCTGGTTCAATT	0.398000													24	109					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55591229	55591229	+	Missense_Mutation	SNP	G	A	A	rs138398244		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:55591229G>A	uc001jju.1	-	30	4443	c.4048C>T	c.(4048-4050)CGC>TGC	p.R1350C	PCDH15_uc010qhq.1_Missense_Mutation_p.R1355C|PCDH15_uc010qhr.1_Missense_Mutation_p.R1350C|PCDH15_uc010qhs.1_Missense_Mutation_p.R1362C|PCDH15_uc010qht.1_Missense_Mutation_p.R1357C|PCDH15_uc010qhu.1_Missense_Mutation_p.R1350C|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1350C|PCDH15_uc010qhw.1_Missense_Mutation_p.R1313C|PCDH15_uc010qhx.1_Missense_Mutation_p.R1279C|PCDH15_uc010qhy.1_Missense_Mutation_p.R1355C|PCDH15_uc010qhz.1_Missense_Mutation_p.R1350C|PCDH15_uc010qia.1_Missense_Mutation_p.R1328C|PCDH15_uc010qib.1_Missense_Mutation_p.R1328C	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1350	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCAGAATGCGTCCTCCTTCC	0.413000										HNSCC(58;0.16)			22	92					0	0	0	0
TNKS2	80351	broad.mit.edu	37	10	93586790	93586790	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:93586790A>G	uc001khp.2	+	8	1109	c.812A>G	c.(811-813)AAT>AGT	p.N271S		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	271	ANK 5.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GCCTGTGTAAATGCAATGGAC	0.368000													15	81					0	0	0	0
RNH1	6050	broad.mit.edu	37	11	494726	494726	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:494726C>G	uc001lpk.1	-	9	2759	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	RNH1_uc001lpl.1_Missense_Mutation_p.E451Q|RNH1_uc001lpm.1_Missense_Mutation_p.E451Q|RNH1_uc001lpn.1_Missense_Mutation_p.E451Q|RNH1_uc001lpo.1_Missense_Mutation_p.E451Q|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Missense_Mutation_p.E451Q|RNH1_uc001lpt.1_Missense_Mutation_p.E208Q|RNH1_uc001lpq.1_Missense_Mutation_p.E451Q|RNH1_uc001lpr.1_Missense_Mutation_p.E451Q|RNH1_uc001lps.1_Missense_Mutation_p.E451Q	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	451					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGTCCTTCTCCAGGGCCTGC	0.657000													21	131					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30032400	30032400	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:30032400G>A	uc001msk.2	-	2	2978	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	609						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TAGATACTCTGACTTGTCCCC	0.463000													18	82					0	0	0	0
KBTBD4	55709	broad.mit.edu	37	11	47594881	47594881	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:47594881C>T	uc001nfx.2	-	4	1329	c.1158G>A	c.(1156-1158)GAG>GAA	p.E386E	PTPMT1_uc001nfs.3_3'UTR|PTPMT1_uc001nfv.3_3'UTR|PTPMT1_uc009ylt.2_3'UTR|PTPMT1_uc001nfu.3_3'UTR|NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Silent_p.E411E|KBTBD4_uc001nfz.2_Silent_p.E402E|KBTBD4_uc001nfy.2_Silent_p.E386E	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	386	Kelch 4.									ovary(1)|central_nervous_system(1)	2						GATCATTCTCCTCCCCCCCTA	0.512000													27	94					0	0	0	0
OR5L1	219437	broad.mit.edu	37	11	55579185	55579185	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:55579185G>T	uc001nhw.1	+	1	243	c.243G>T	c.(241-243)ATG>ATT	p.M81I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGCCAAAAATGTTGGCTAATA	0.458000													64	246					1.69475e-38	2.07635e-38	1	0
OR8J1	219477	broad.mit.edu	37	11	56127847	56127847	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:56127847A>T	uc010rjh.1	+	1	125	c.125A>T	c.(124-126)AAC>ATC	p.N42I		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGGCAGGGAACCTGGGCATC	0.493000													34	132					0	0	0	0
RARRES3	5920	broad.mit.edu	37	11	63312266	63312266	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:63312266G>A	uc001nxf.3	+	3	360	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	98					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						TTCTGCGAAGGAGATGGTTGG	0.517000													51	144					0	0	0	0
FERMT3	83706	broad.mit.edu	37	11	63990913	63990913	+	Silent	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:63990913G>A	uc001nyl.2	+	15	2102	c.1953G>A	c.(1951-1953)GAG>GAA	p.E651E	FERMT3_uc001nym.2_Silent_p.E647E|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	651					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GTGGGGAGGAGCTGGATGAAG	0.622000													16	43					0	0	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366325	64366325	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:64366325C>T	uc001oam.1	+	6	1747	c.1000C>T	c.(1000-1002)CCT>TCT	p.P334S	SLC22A12_uc009ypr.1_Missense_Mutation_p.P359S|SLC22A12_uc001oal.1_Missense_Mutation_p.P113S|SLC22A12_uc009yps.1_Missense_Mutation_p.P300S|SLC22A12_uc001oan.1_Missense_Mutation_p.P226S|SLC22A12_uc009ypt.2_Missense_Mutation_p.P152S	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	334					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GGGCCAGCCTCCTGCCAGCCT	0.672000													4	71					0	0	0	0
NAALADL1	10004	broad.mit.edu	37	11	64813578	64813578	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:64813578C>A	uc001ocn.2	-	16	1880	c.1864G>T	c.(1864-1866)GTG>TTG	p.V622L	NAALADL1_uc010rnw.1_Missense_Mutation_p.V98L|NAALADL1_uc009ypz.2_RNA	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	622	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						ACTGCAGTCACCAGAGGCCCT	0.607000													20	76					7.45023e-12	8.50797e-12	1	0
MUS81	80198	broad.mit.edu	37	11	65631171	65631171	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:65631171G>C	uc001ofv.3	+	9	1293	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	314	ERCC4.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		GGTGGCCCAGGAGACCAATCC	0.657000								Homologous_recombination					10	109					0	0	0	0
NPAS4	266743	broad.mit.edu	37	11	66192180	66192180	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:66192180G>T	uc001ohx.1	+	7	1995	c.1819G>T	c.(1819-1821)GAA>TAA	p.E607*	NPAS4_uc010rpc.1_Nonsense_Mutation_p.E397*	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	607					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTGGTGCCCGAAGGCCTGCT	0.592000													20	349					2.37509e-13	2.7462e-13	1	0
ATM	472	broad.mit.edu	37	11	108224518	108224518	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:108224518C>G	uc001pkb.1	+	60	9082	c.8697C>G	c.(8695-8697)ATC>ATG	p.I2899M	ATM_uc009yxr.1_Missense_Mutation_p.I2899M|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.I1551M	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2899	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGGCAAAATCCTTCCTACTC	0.398000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			85	115					0	0	0	0
CPNE8	144402	broad.mit.edu	37	12	39223185	39223185	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:39223185T>A	uc001rls.1	-	6	487	c.403A>T	c.(403-405)ATA>TTA	p.I135L		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	135										pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				ACTTACACTATTGGTTTTTCC	0.363000													46	213					0	0	0	0
XPOT	11260	broad.mit.edu	37	12	64818445	64818445	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:64818445C>G	uc001ssb.2	+	12	1675	c.1249C>G	c.(1249-1251)CAA>GAA	p.Q417E		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	417					intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		CAGGCTTGCTCAAGTTTCACC	0.373000													20	116					0	0	0	0
CHPT1	56994	broad.mit.edu	37	12	102091698	102091698	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:102091698C>T	uc001tin.2	+	1	282	c.59C>T	c.(58-60)CCG>CTG	p.P20L	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.P20L	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	20					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						CTGAGCGAGCCGCTGAGCGCG	0.796000													3	6					0	0	0	0
GNPTAB	79158	broad.mit.edu	37	12	102158435	102158435	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:102158435T>C	uc001tit.2	-	13	2439	c.2260A>G	c.(2260-2262)ATA>GTA	p.I754V		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	754					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						TCATCTGTTATTATAGCTTGA	0.383000													19	69					0	0	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122966496	122966496	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:122966496T>C	uc001ucn.2	-	9	1002	c.871A>G	c.(871-873)ATT>GTT	p.I291V	ZCCHC8_uc001ucm.2_Missense_Mutation_p.I53V|ZCCHC8_uc009zxp.2_Missense_Mutation_p.I53V|ZCCHC8_uc009zxq.2_Missense_Mutation_p.I53V	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	291						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TAGTACCTAATAACTCCTGGC	0.383000													8	26					0	0	0	0
CENPJ	55835	broad.mit.edu	37	13	25458151	25458151	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:25458151A>C	uc001upt.3	-	16	4027	c.3774T>G	c.(3772-3774)GAT>GAG	p.D1258E	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	1258					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CTTCTTGTCCATCAGGAAATA	0.358000													27	94					0	0	0	0
PIBF1	10464	broad.mit.edu	37	13	73366606	73366606	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:73366606C>G	uc001vjc.2	+	3	579	c.274C>G	c.(274-276)CTT>GTT	p.L92V	PIBF1_uc001vja.1_Missense_Mutation_p.L92V|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.L92V|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	92						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GGAGGAGAAACTTAATGATGC	0.284000													9	67					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99476724	99476724	+	Silent	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:99476724G>C	uc001vnt.2	-	46	5116	c.5061C>G	c.(5059-5061)GTC>GTG	p.V1687V	DOCK9_uc001vnw.2_Silent_p.V1686V|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.V1664V|DOCK9_uc001vnq.2_Silent_p.V236V|DOCK9_uc001vnr.2_Silent_p.V330V|DOCK9_uc010tin.1_Silent_p.V307V|DOCK9_uc001vns.2_Silent_p.V236V|DOCK9_uc010tio.1_Silent_p.V356V|DOCK9_uc010tip.1_Silent_p.V397V|DOCK9_uc001vnu.1_Silent_p.V236V|DOCK9_uc010tiq.1_Silent_p.V642V	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1687	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGGGGTAATGACCCTGAAGG	0.537000													33	138					0	0	0	0
MDGA2	161357	broad.mit.edu	37	14	47504386	47504386	+	Silent	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:47504386C>A	uc001wwj.3	-	8	1636	c.1440G>T	c.(1438-1440)GCG>GCT	p.A480A	MDGA2_uc001wwi.3_Silent_p.A251A|MDGA2_uc010ani.2_Silent_p.A40A	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	480	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CTTCTTTATCCGCTCTAGACC	0.413000													55	230					6.20943e-19	7.36375e-19	1	0
DLST	1743	broad.mit.edu	37	14	75367830	75367830	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:75367830G>A	uc001xqv.2	+	14	1184	c.1121G>A	c.(1120-1122)GGA>GAA	p.G374E	DLST_uc001xqu.2_Missense_Mutation_p.G286E|DLST_uc001xqt.2_Missense_Mutation_p.G290E|DLST_uc010tuw.1_Missense_Mutation_p.G288E	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	374					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		ATTAGCAATGGAGGCGTTTTT	0.473000													21	94					0	0	0	0
DICER1	23405	broad.mit.edu	37	14	95560403	95560403	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:95560403G>T	uc001ydw.2	-	25	5368	c.5186C>A	c.(5185-5187)CCG>CAG	p.P1729Q	DICER1_uc010avh.1_Missense_Mutation_p.P627Q|DICER1_uc001ydv.2_Missense_Mutation_p.P1719Q|DICER1_uc001ydx.2_Missense_Mutation_p.P1729Q	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1729	RNase III 2.			P->E: No effect on activity.	negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGGACCCCCGGGGAGTGCTG	0.522000			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				6	99					2.0095e-06	2.18681e-06	1	0
DEGS2	123099	broad.mit.edu	37	14	100615443	100615443	+	Silent	SNP	G	A	A	rs145891510		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:100615443G>A	uc001ygx.2	-	2	775	c.687C>T	c.(685-687)TTC>TTT	p.F229F		NM_206918	NP_996801	Q6QHC5	DEGS2_HUMAN	degenerative spermatocyte homolog 2, lipid	229	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity				0		Melanoma(154;0.212)				GCTCGGCCACGAAGTGGCCCG	0.622000													10	129					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	106091432	106091432	+	RNA	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:106091432C>G	uc010tyt.1	-	3647		c.62076G>C			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron					Parts of antibodies, mostly variable regions.												0						ACCAGTTGAACTGGACCTCGG	0.602000													31	170					0	0	0	0
SNORD115-9	100033446	broad.mit.edu	37	15	25430645	25430645	+	5'Flank	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:25430645G>A	uc001yzc.1	+						uc001yyy.1_RNA|uc001yza.1_RNA|SNORD115-10_uc001yzd.1_5'Flank	NR_003297				Homo sapiens small nucleolar RNA, C/D box 115-5 (SNORD115-5), non-coding RNA.												0						ACCAGTGTCTGCCAGCCACGT	0.582000													9	35					0	0	0	0
RTF1	23168	broad.mit.edu	37	15	41769676	41769676	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:41769676G>A	uc001zny.2	+	14	1715	c.1703G>A	c.(1702-1704)CGG>CAG	p.R568Q		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	568					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CAGCGGAACCGGGAGTGGAAC	0.433000													13	111					0	0	0	0
PARP16	54956	broad.mit.edu	37	15	65555578	65555578	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:65555578C>T	uc002aoo.2	-	4	854	c.600G>A	c.(598-600)TGG>TGA	p.W200*	PARP16_uc002aop.2_Nonsense_Mutation_p.W85*|PARP16_uc002aoq.2_Nonsense_Mutation_p.W200*	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	200	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						GGCTGTGCTGCCACCCATGGC	0.582000													11	43					0	0	0	0
MPI	4351	broad.mit.edu	37	15	75189376	75189376	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:75189376C>T	uc002azc.1	+	7	874	c.869C>T	c.(868-870)TCA>TTA	p.S290L	MPI_uc002azd.1_Intron|MPI_uc010ulx.1_Missense_Mutation_p.S240L|MPI_uc002aze.1_Missense_Mutation_p.S229L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	290					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						ATGGCGTGTTCAGACAACACA	0.537000													48	148					0	0	0	0
FAM173A	65990	broad.mit.edu	37	16	772479	772479	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:772479C>T	uc002cje.2	+	5	747	c.630C>T	c.(628-630)TCC>TCT	p.S210S		NM_023933	NP_076422	Q9BQD7	F173A_HUMAN	hypothetical protein LOC65990	210						integral to membrane				pancreas(1)	1						AGGCCGCCTCCTCGCGGATAC	0.637000													13	30					0	0	0	0
CHD9	80205	broad.mit.edu	37	16	53358697	53358697	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:53358697C>T	uc002ehb.2	+	38	8748	c.8584C>T	c.(8584-8586)CCT>TCT	p.P2862S	CHD9_uc002egy.2_Missense_Mutation_p.P2846S|CHD9_uc002ehc.2_Missense_Mutation_p.P2847S|CHD9_uc002ehf.2_Missense_Mutation_p.P1960S|CHD9_uc010cbw.2_Missense_Mutation_p.P928S	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2862					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TGAACCAAGTCCTCTCAATGA	0.398000													7	20					0	0	0	0
GFOD2	81577	broad.mit.edu	37	16	67709084	67709084	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:67709084C>G	uc002eub.2	-	3	1427	c.1132G>C	c.(1132-1134)GAG>CAG	p.E378Q	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.E273Q	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	378						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TGAAGTGCCTCACACAGGTTC	0.627000													35	182					0	0	0	0
SLC7A6OS	84138	broad.mit.edu	37	16	68344358	68344358	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:68344358G>T	uc002evw.1	-	2	370	c.351C>A	c.(349-351)AGC>AGA	p.S117R	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	117					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		ACTCCTGGCCGCTCGAGGTGG	0.672000													5	12					0.00116845	0.00122126	1	0
ZFPM1	161882	broad.mit.edu	37	16	88601319	88601319	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:88601319A>T	uc002fkv.2	+	10	2986	c.2953A>T	c.(2953-2955)AGC>TGC	p.S985C		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	985	C2HC-type 5.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CAAGTTCAGCAGCCTGTCCAC	0.622000													24	68					0	0	0	0
DPH1	1801	broad.mit.edu	37	17	1939319	1939319	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:1939319G>T	uc002fts.2	+	4	367	c.349G>T	c.(349-351)GTG>TTG	p.V117L	DPH1_uc002ftr.1_RNA|DPH1_uc002ftt.2_Missense_Mutation_p.V112L|DPH1_uc010cjx.2_Intron|DPH1_uc010vqs.1_Missense_Mutation_p.V127L|DPH1_uc002ftu.2_5'Flank|DPH1_uc002ftv.2_5'Flank	NM_001383	NP_001374	Q9BZG8	DPH1_HUMAN	diptheria toxin resistance protein required for	117					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				pancreas(1)	1						GGCTTGCTGTGTGGATGACTT	0.647000													17	47					7.21436e-19	8.501e-19	1	0
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	66					4.16121e-05	4.42428e-05	1	0
Unknown	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	G	G	rs149119138	by1000genomes	TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:21731144T>G	uc002gyy.3	+	2	571	c.446T>G	c.(445-447)CTG>CGG	p.L149R						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		GTCCTGCGTCTGAGAGGTGGT	0.542000													5	49					0	0	0	0
DBF4B	80174	broad.mit.edu	37	17	42828155	42828155	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:42828155C>G	uc002ihf.2	+	14	1595	c.1382C>G	c.(1381-1383)GCT>GGT	p.A461G	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	461					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				ACTTCCTTGGCTCTGCTGCCT	0.632000													26	93					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58343387	58343387	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:58343387C>T	uc002iyo.1	-	8	1163	c.877G>A	c.(877-879)GTG>ATG	p.V293M	USP32_uc010wov.1_Missense_Mutation_p.V293M	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	293	EF-hand 3.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AGTGCAACCACCATGTCTCTC	0.393000													7	135					0	0	0	0
ARSG	22901	broad.mit.edu	37	17	66391318	66391318	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:66391318C>T	uc002jhc.2	+	10	1992	c.1196C>T	c.(1195-1197)TCA>TTA	p.S399L	ARSG_uc002jhb.1_Missense_Mutation_p.S235L	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	399					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTGGCCGGTCACAGCCTGGG	0.582000													5	89					0	0	0	0
SLC9A3R1	9368	broad.mit.edu	37	17	72764743	72764743	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:72764743G>A	uc002jlo.2	+	6	1248	c.1025G>A	c.(1024-1026)CGG>CAG	p.R342Q	SLC9A3R1_uc002jlp.2_Missense_Mutation_p.R186Q	NM_004252	NP_004243	O14745	NHRF1_HUMAN	sodium/hydrogen exchanger regulatory factor 1	342					apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association				0						AGCAGCAAACGGGCCCCGCAG	0.612000													38	119					0	0	0	0
COLEC12	81035	broad.mit.edu	37	18	346545	346545	+	Silent	SNP	C	T	T	rs147354214	byFrequency	TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr18:346545C>T	uc002kkm.2	-	5	1292	c.1077G>A	c.(1075-1077)ACG>ACA	p.T359T		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	359	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				TGCTGGTCAGCGTCCGCAGGT	0.473000													16	55					0	0	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21745031	21745031	+	Silent	SNP	C	T	T	rs143353189		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr18:21745031C>T	uc002kve.2	-	27	2922	c.2748G>A	c.(2746-2748)ACG>ACA	p.T916T	OSBPL1A_uc002kvd.2_Silent_p.T403T|OSBPL1A_uc010xbc.1_Silent_p.T534T	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	916					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GCACGCACCTCGTCTTCCAGT	0.532000													69	262					0	0	0	0
SMAD4	4089	broad.mit.edu	37	18	48591919	48591919	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr18:48591919G>A	uc010xdp.1	+	9	1620	c.1082G>A	c.(1081-1083)CGC>CAC	p.R361H	SMAD4_uc002lfb.3_Missense_Mutation_p.R206H	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	361	MH2.		R -> H (in a colorectal cancer sample; somatic mutation).|R -> C (in JPS).		BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.R361C(6)|p.R361H(3)|p.?(2)|p.R361S(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGAGGAGATCGCTTTTGTTTG	0.413000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				16	63					0	0	0	0
ACSBG2	81616	broad.mit.edu	37	19	6185605	6185605	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:6185605C>T	uc002mef.1	+	11	1708	c.1481C>T	c.(1480-1482)TCT>TTT	p.S494F	ACSBG2_uc002mee.1_Missense_Mutation_p.S307F|ACSBG2_uc002meg.1_Missense_Mutation_p.S494F|ACSBG2_uc002meh.1_Missense_Mutation_p.S494F|ACSBG2_uc002mei.1_Missense_Mutation_p.S444F|ACSBG2_uc010xiz.1_Missense_Mutation_p.S494F	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	494					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGGCTACACTCTGGGGATCTG	0.552000													9	151					0	0	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221394	10221394	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:10221394G>A	uc002mna.2	+	11	1053	c.1053G>A	c.(1051-1053)ATG>ATA	p.M351I	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.M351I|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.M351I|PPAN_uc002mnb.1_Missense_Mutation_p.M298I	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	351					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGGAGGGCATGAAGAAGGCAC	0.627000													16	63					0	0	0	0
S1PR2	9294	broad.mit.edu	37	19	10335464	10335464	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:10335464T>A	uc002mnl.2	-	2	229	c.118A>T	c.(118-120)ATC>TTC	p.I40F		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	40	Helical; Name=1; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						AGGATGACGATGAAGGCCGAG	0.552000													43	235					0	0	0	0
PKN1	5585	broad.mit.edu	37	19	14569141	14569141	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:14569141A>T	uc002myp.2	+	9	1541	c.1373A>T	c.(1372-1374)CAT>CTT	p.H458L	PKN1_uc002myq.2_Missense_Mutation_p.H464L	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	458	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						AATGAGAGGCATGAGGTGCAG	0.577000													10	77					0	0	0	0
ZNF253	56242	broad.mit.edu	37	19	20003522	20003522	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:20003522T>C	uc002noj.2	+	4	1558	c.1466T>C	c.(1465-1467)TTA>TCA	p.L489S	ZNF253_uc002nok.2_Missense_Mutation_p.L413S|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	489					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACAGATCTTTTAAATGTTCCT	0.363000													18	68					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	30934639	30934639	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:30934639A>G	uc002nsu.1	+	2	308	c.170A>G	c.(169-171)GAG>GGG	p.E57G	ZNF536_uc010edd.1_Missense_Mutation_p.E57G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCCAACCCCGAGGAGAAGCCC	0.677000													21	88					0	0	0	0
SHANK1	50944	broad.mit.edu	37	19	51165265	51165265	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:51165265C>T	uc002psx.1	-	23	6462	c.6443G>A	c.(6442-6444)CGC>CAC	p.R2148H	SHANK1_uc002psw.1_Missense_Mutation_p.R1532H	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2148	SAM.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GATGTTCATGCGGTGGCCCAC	0.617000													16	108					0	0	0	0
ZNF667	63934	broad.mit.edu	37	19	56952944	56952944	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:56952944C>T	uc002qnd.2	-	5	1582	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K	ZNF667_uc010etl.2_Missense_Mutation_p.E256K|ZNF667_uc002qne.2_Missense_Mutation_p.E474K|ZNF667_uc010etm.2_Missense_Mutation_p.E417K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	474	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CCACATTCCTCACACTGGTAG	0.398000													20	102					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57325748	57325748	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:57325748A>T	uc002qnu.2	-	7	4413	c.4062T>A	c.(4060-4062)CAT>CAA	p.H1354Q	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.H1325Q|PEG3_uc002qnv.2_Missense_Mutation_p.H1354Q|PEG3_uc002qnw.2_Missense_Mutation_p.H1230Q|PEG3_uc002qnx.2_Missense_Mutation_p.H1228Q|PEG3_uc010etr.2_Missense_Mutation_p.H1354Q	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1354	Glu-rich.|C2H2-type 10.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTCTTCCAGATGAAGCTCCT	0.363000													23	60					0	0	0	0
ZNF264	9422	broad.mit.edu	37	19	57723539	57723539	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:57723539C>T	uc002qob.2	+	4	1487	c.1074C>T	c.(1072-1074)CTC>CTT	p.L358L		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	358	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GGTCATATCTCATGTGGCACC	0.517000													25	127					0	0	0	0
ATAD2B	54454	broad.mit.edu	37	2	24009039	24009039	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:24009039A>T	uc002rek.3	-	21	3125	c.2831T>A	c.(2830-2832)TTA>TAA	p.L944*	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Nonsense_Mutation_p.L189*|ATAD2B_uc002rej.3_Nonsense_Mutation_p.L112*	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	944	Potential.						ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATTCTGATAATTGACGAGG	0.443000													9	13					0	0	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530848	80530848	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:80530848G>C	uc002sok.1	-	2	367	c.97C>G	c.(97-99)CCC>GCC	p.P33A	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	33						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGGGCGGCGGGCAGCATCTGA	0.677000										HNSCC(69;0.2)			5	20					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97779539	97779539	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:97779539C>T	uc010yva.1	+	1	307	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ANKRD36_uc002sxn.2_Silent_p.F21F|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Silent_p.F21F|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512000													5	140					0	0	0	0
IWS1	55677	broad.mit.edu	37	2	128244226	128244226	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:128244226C>T	uc002ton.2	-	13	2534	c.2231G>A	c.(2230-2232)GGA>GAA	p.G744E		NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	744					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCCAGGATCTCCAGGTCTAAG	0.507000													5	52					0	0	0	0
IWS1	55677	broad.mit.edu	37	2	128263073	128263073	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:128263073C>G	uc002ton.2	-	3	709	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	IWS1_uc010yzl.1_RNA|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	136	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		AGAAGTTCCTCATTTTCAGAG	0.483000													22	174					0	0	0	0
MBD5	55777	broad.mit.edu	37	2	149247786	149247786	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:149247786C>T	uc002twm.3	+	12	4874	c.3886C>T	c.(3886-3888)CGA>TGA	p.R1296*	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Nonsense_Mutation_p.R1296*|MBD5_uc002two.2_Nonsense_Mutation_p.R554*|MBD5_uc002twp.2_Nonsense_Mutation_p.R346*	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1296						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GAATAGACCTCGACAGAGTCG	0.413000													6	44					0	0	0	0
MARCH7	64844	broad.mit.edu	37	2	160605112	160605112	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:160605112G>C	uc002uax.2	+	5	1433	c.1311G>C	c.(1309-1311)CAG>CAC	p.Q437H	MARCH7_uc010foq.2_Missense_Mutation_p.Q437H|MARCH7_uc010zcn.1_Missense_Mutation_p.Q381H|MARCH7_uc010for.2_Missense_Mutation_p.Q399H|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	437							ligase activity|zinc ion binding				0						TTGAAGCACAGAATGATCCTC	0.448000													5	147					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167141152	167141152	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:167141152C>T	uc010fpl.2	-	12	2126	c.1785G>A	c.(1783-1785)CAG>CAA	p.Q595Q	uc002udp.2_Intron|SCN9A_uc002udr.1_Silent_p.Q466Q|SCN9A_uc002uds.1_Silent_p.Q466Q|SCN9A_uc002udt.1_Silent_p.Q466Q	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	595						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCGTCGCTCCTGGGGTCTGT	0.537000													17	75					0	0	0	0
HOXD3	3232	broad.mit.edu	37	2	177036256	177036256	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:177036256G>A	uc002ukt.1	+	3	729	c.553G>A	c.(553-555)GAG>AAG	p.E185K		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	185					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGAGAGCTGCGAGGACAAGAG	0.627000													5	33					0	0	0	0
SSFA2	6744	broad.mit.edu	37	2	182765561	182765561	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:182765561A>G	uc002uoi.2	+	7	964	c.642A>G	c.(640-642)ATA>ATG	p.I214M	SSFA2_uc002uoh.2_Missense_Mutation_p.I214M|SSFA2_uc002uoj.2_Missense_Mutation_p.I214M|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.I61M|SSFA2_uc002uol.2_Missense_Mutation_p.I61M	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	214						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			CCAAAGGGATAGATATTAAAG	0.308000													20	71					0	0	0	0
ITGAV	3685	broad.mit.edu	37	2	187455218	187455218	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:187455218C>T	uc002upq.2	+	1	429	c.153C>T	c.(151-153)TTC>TTT	p.F51F	ITGAV_uc010frs.2_Silent_p.F51F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	51	FG-GAP 1.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ACTTCGGCTTCGCCGTGGATT	0.637000													15	50					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196822095	196822095	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:196822095G>C	uc002utj.3	-	19	3069	c.2968C>G	c.(2968-2970)CTG>GTG	p.L990V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	990	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGGCTCCAGATACAGCCAC	0.483000													4	105					0	0	0	0
SATB2	23314	broad.mit.edu	37	2	200246428	200246428	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:200246428G>C	uc002uuy.1	-	4	1279	c.462C>G	c.(460-462)ATC>ATG	p.I154M	SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Missense_Mutation_p.I154M|SATB2_uc002uva.1_Missense_Mutation_p.I154M	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	154						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTGTAATTGGATTTTCAACG	0.473000													5	137					0	0	0	0
C2orf60	129450	broad.mit.edu	37	2	200801155	200801155	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:200801155G>C	uc002uvi.3	-	6	813	c.547C>G	c.(547-549)CGA>GGA	p.R183G	C2orf60_uc002uvj.3_Missense_Mutation_p.R20G|C2orf60_uc002uvk.3_Intron|C2orf60_uc010fss.2_Missense_Mutation_p.R20G	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	183	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						TGGGCATCTCGAGGACTGAAG	0.299000													6	213					0	0	0	0
CLK1	1195	broad.mit.edu	37	2	201726073	201726073	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:201726073T>A	uc002uwe.2	-	3	459	c.278A>T	c.(277-279)CAT>CTT	p.H93L	CLK1_uc010zhi.1_Missense_Mutation_p.H135L|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	93					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						CCGGCTTTCATGGTCTCTTTG	0.408000													68	226					0	0	0	0
TTLL4	9654	broad.mit.edu	37	2	219602407	219602407	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:219602407C>T	uc002viy.2	+	3	378	c.8C>T	c.(7-9)TCA>TTA	p.S3L	TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Missense_Mutation_p.S3L	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	3					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTCATGGCCTCAGCAGGAACA	0.572000													8	71					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881860	228881860	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:228881860G>A	uc002vpq.2	-	7	3757	c.3710C>T	c.(3709-3711)TCG>TTG	p.S1237L	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1237L|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1237L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1237						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGCATGGACGACTGTCTGTG	0.562000													29	133					0	0	0	0
C20orf194	25943	broad.mit.edu	37	20	3321254	3321254	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:3321254T>C	uc002wii.2	-	10	929	c.878A>G	c.(877-879)AAT>AGT	p.N293S	C20orf194_uc002wij.3_Missense_Mutation_p.N32S|C20orf194_uc002wik.2_5'UTR|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	293											0						TGTGGAGTGATTACCAAAGAG	0.493000													8	44					0	0	0	0
FAM83C	128876	broad.mit.edu	37	20	33876620	33876620	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:33876620T>C	uc010zux.1	-	2	773	c.655A>G	c.(655-657)ATG>GTG	p.M219V	FAM83C_uc002xcb.1_Missense_Mutation_p.M43V	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	219										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TTGAGGTCCATCTTGTAGCAC	0.642000													8	61					0	0	0	0
CEP250	11190	broad.mit.edu	37	20	34054812	34054812	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:34054812G>A	uc002xcm.2	+	9	1185	c.514G>A	c.(514-516)GGG>AGG	p.G172R	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_5'UTR	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	172					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTACCTGAAAGGGGAGCACGG	0.527000													23	98					0	0	0	0
CHAF1B	8208	broad.mit.edu	37	21	37783871	37783871	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr21:37783871A>T	uc002yvj.2	+	11	1168	c.1030A>T	c.(1030-1032)ATA>TTA	p.I344L		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	344	WD 7.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						CGTGTCTAATATACATTACCA	0.537000													61	229					0	0	0	0
BAP1	8314	broad.mit.edu	37	3	52437288	52437288	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:52437288T>G	uc003ddx.2	-	14	1871	c.1756A>C	c.(1756-1758)ATC>CTC	p.I586L	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	586					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		ATTGGTCTGATGGAGGGCGAG	0.597000			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								17	36					0	0	0	0
ARL13B	200894	broad.mit.edu	37	3	93714788	93714788	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:93714788G>A	uc003drc.2	+	2	416	c.130G>A	c.(130-132)GAA>AAA	p.E44K	ARL13B_uc010hop.2_Silent_p.E13E|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.E44K|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	44							GTP binding				0						AATCCAAGGAGGTAAGCTGAA	0.299000													16	28					0	0	0	0
STX19	415117	broad.mit.edu	37	3	93733390	93733390	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:93733390C>T	uc003drh.1	-	2	981	c.724G>A	c.(724-726)GAA>AAA	p.E242K	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	242	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0						TCTCCTTGTTCCTCTACTAAA	0.318000													6	56					0	0	0	0
BBX	56987	broad.mit.edu	37	3	107517519	107517519	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:107517519C>T	uc010hpr.2	+	16	2830	c.2503C>T	c.(2503-2505)CTT>TTT	p.L835F	BBX_uc003dwk.3_Missense_Mutation_p.L805F|BBX_uc003dwl.3_Silent_p.T498T|BBX_uc003dwm.3_Missense_Mutation_p.L805F|BBX_uc003dwo.3_Silent_p.T154T	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GATTACACACCTTGTCAGGAC	0.398000													3	70					0	0	0	0
LSAMP	4045	broad.mit.edu	37	3	115529219	115529219	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:115529219G>A	uc003ebt.2	-	7	1462	c.962C>T	c.(961-963)GCC>GTC	p.A321V	LSAMP_uc011bis.1_Missense_Mutation_p.A344V	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	321					cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CAGTGGTACGGCCAGACTGAT	0.423000													13	21					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130718428	130718428	+	Missense_Mutation	SNP	A	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:130718428A>C	uc003enl.2	+	27	2776	c.2554A>C	c.(2554-2556)ATC>CTC	p.I852L	ATP2C1_uc011blg.1_Missense_Mutation_p.I886L|ATP2C1_uc011blh.1_Missense_Mutation_p.I847L|ATP2C1_uc011bli.1_Missense_Mutation_p.I886L|ATP2C1_uc003enk.2_Missense_Mutation_p.I836L|ATP2C1_uc003enm.2_Missense_Mutation_p.I852L|ATP2C1_uc003enn.2_Missense_Mutation_p.I836L|ATP2C1_uc003eno.2_Missense_Mutation_p.I852L|ATP2C1_uc003enp.2_Missense_Mutation_p.I852L|ATP2C1_uc003enq.2_Missense_Mutation_p.I852L|ATP2C1_uc003enr.2_Missense_Mutation_p.I852L|ATP2C1_uc003ens.2_Missense_Mutation_p.I852L|ATP2C1_uc003ent.2_Missense_Mutation_p.I852L|ATP2C1_uc003enu.2_Missense_Mutation_p.I530L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	852	Helical; Name=9; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TCTTGGATCCATCATGGGACA	0.393000									Hailey-Hailey_disease				21	123					0	0	0	0
AADACL2	344752	broad.mit.edu	37	3	151451836	151451836	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:151451836G>A	uc003ezc.2	+	1	133	c.13G>A	c.(13-15)GCT>ACT	p.A5T	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	5						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GGGGCTAAAAGCTCTCTGTTT	0.383000													4	45					0	0	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198764	170198764	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:170198764T>C	uc003fgz.2	-	7	1623	c.1307A>G	c.(1306-1308)GAC>GGC	p.D436G	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	436						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			ACCATCAATGTCACTCTCAGG	0.498000													18	115					0	0	0	0
TNIK	23043	broad.mit.edu	37	3	170802049	170802049	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:170802049C>A	uc003fhh.2	-	26	3409	c.3064G>T	c.(3064-3066)GTG>TTG	p.V1022L	TNIK_uc003fhi.2_Missense_Mutation_p.V967L|TNIK_uc003fhj.2_Missense_Mutation_p.V993L|TNIK_uc003fhk.2_Missense_Mutation_p.V1014L|TNIK_uc003fhl.2_Missense_Mutation_p.V938L|TNIK_uc003fhm.2_Missense_Mutation_p.V959L|TNIK_uc003fhn.2_Missense_Mutation_p.V985L|TNIK_uc003fho.2_Missense_Mutation_p.V930L|TNIK_uc003fhg.2_Missense_Mutation_p.V200L|TNIK_uc003fhp.2_5'Flank	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1022	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ACATTTACCACCGAAATCTTT	0.403000													12	190					0.00136819	0.001422	1	0
ECT2	1894	broad.mit.edu	37	3	172482216	172482216	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:172482216C>T	uc003fii.2	+	11	1262	c.1124C>T	c.(1123-1125)TCA>TTA	p.S375L	ECT2_uc010hwv.1_Missense_Mutation_p.S406L|ECT2_uc003fih.2_Missense_Mutation_p.S374L|ECT2_uc003fij.1_Missense_Mutation_p.S375L|ECT2_uc003fik.1_Missense_Mutation_p.S375L|ECT2_uc003fil.1_Missense_Mutation_p.S406L	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	375					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAGCGCCCATCAGCTGAGCAT	0.453000													6	191					0	0	0	0
MAP3K13	9175	broad.mit.edu	37	3	185191117	185191117	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:185191117C>T	uc010hyf.2	+	12	2264	c.1998C>T	c.(1996-1998)TGC>TGT	p.C666C	MAP3K13_uc011brt.1_Silent_p.C459C|MAP3K13_uc011bru.1_Silent_p.C522C|MAP3K13_uc003fpi.2_Silent_p.C666C|MAP3K13_uc010hyg.2_Silent_p.C356C	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	666					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TAGCAACCTGCGCCAACAACC	0.587000													123	173					0	0	0	0
LPP	4026	broad.mit.edu	37	3	188590462	188590462	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:188590462G>T	uc003frs.1	+	10	1867	c.1621G>T	c.(1621-1623)GAG>TAG	p.E541*	LPP_uc011bsg.1_Nonsense_Mutation_p.E394*|LPP_uc011bsi.1_Nonsense_Mutation_p.E541*|LPP_uc011bsj.1_Nonsense_Mutation_p.E378*	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	541	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TGTGTGCAAGGAGCCTATTAT	0.532000			T	HMGA2|MLL|C12orf9	lipoma|leukemia								9	154					2.80697e-09	3.1664e-09	1	0
TP63	8626	broad.mit.edu	37	3	189526287	189526287	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:189526287C>T	uc003fry.2	+	4	640	c.551C>T	c.(550-552)TCG>TTG	p.S184L	TP63_uc003frx.2_Missense_Mutation_p.S184L|TP63_uc003frz.2_Missense_Mutation_p.S184L|TP63_uc010hzc.1_Missense_Mutation_p.S184L|TP63_uc003fsa.2_Missense_Mutation_p.S90L|TP63_uc003fsb.2_Missense_Mutation_p.S90L|TP63_uc003fsc.2_Missense_Mutation_p.S90L|TP63_uc003fsd.2_Missense_Mutation_p.S90L|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.S65L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	184			S -> L (in head and neck cancer).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTCCAGCAGTCGAGCACCGCC	0.627000									Hay-Wells_syndrome	HNSCC(45;0.13)			19	108					0	0	0	0
CXXC4	80319	broad.mit.edu	37	4	105412204	105412204	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:105412204G>C	uc003hxg.2	-	1	264	c.249C>G	c.(247-249)ATC>ATG	p.I83M	uc003hxh.1_RNA|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	83					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		CTGTCATGACGATGACCCCTG	0.577000													27	110					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115767138	115767138	+	Silent	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:115767138G>A	uc003ibu.2	-	10	2635	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	652	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGGTGTAGGGAAAAAGTCCA	0.358000													15	56					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126402801	126402801	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:126402801G>T	uc003ifj.3	+	15	12724	c.12724G>T	c.(12724-12726)GGT>TGT	p.G4242C	FAT4_uc011cgp.1_Missense_Mutation_p.G2483C|FAT4_uc003ifi.1_Missense_Mutation_p.G1720C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4242	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGAGCCTTTTGGTGTGAACAG	0.433000													16	74					1.5739e-10	1.78632e-10	1	0
SH3RF1	57630	broad.mit.edu	37	4	170042098	170042098	+	Silent	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:170042098T>C	uc003isa.1	-	8	1724	c.1389A>G	c.(1387-1389)GAA>GAG	p.E463E	SH3RF1_uc010irc.1_Silent_p.E163E	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	463	SH3 3.|Interaction with AKT2 (By similarity).					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TCAGCTCTAGTTCATCCTCTT	0.418000													26	73					0	0	0	0
GLRA3	8001	broad.mit.edu	37	4	175710093	175710093	+	Silent	SNP	A	G	G	rs144360619		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:175710093A>G	uc003ity.1	-	2	576	c.73T>C	c.(73-75)TTG>CTG	p.L25L	GLRA3_uc003itz.1_Silent_p.L25L	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	25					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GTGGCAACCAAACTACAAATA	0.323000													7	38					0	0	0	0
MCCC2	64087	broad.mit.edu	37	5	70930987	70930987	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:70930987G>A	uc003kbs.3	+	10	1051	c.913G>A	c.(913-915)GAA>AAA	p.E305K	MCCC2_uc010iyv.1_Missense_Mutation_p.E305K|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.E174K	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	305	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GGTCACCATTGAACCTTCTGA	0.373000													9	92					0	0	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79738953	79738953	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:79738953G>A	uc003kgr.3	+	6	2733	c.2431G>A	c.(2431-2433)GAA>AAA	p.E811K	ZFYVE16_uc003kgp.2_Missense_Mutation_p.E811K|ZFYVE16_uc003kgq.3_Missense_Mutation_p.E811K|ZFYVE16_uc003kgs.3_Missense_Mutation_p.E811K|ZFYVE16_uc003kgt.3_5'UTR	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	811					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TCAGGCATTTGAAAGGATGAT	0.338000													26	143					0	0	0	0
APC	324	broad.mit.edu	37	5	112173950	112173950	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:112173950A>T	uc010jby.2	+	16	3039	c.2659A>T	c.(2659-2661)ATT>TTT	p.I887F	APC_uc011cvt.1_Missense_Mutation_p.I869F|APC_uc003kpz.3_Missense_Mutation_p.I887F|APC_uc003kpy.3_Missense_Mutation_p.I887F|APC_uc010jbz.2_Missense_Mutation_p.I604F|APC_uc010jca.2_Missense_Mutation_p.I187F	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	887	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGCAGCCCAGATTGCCAAAGT	0.468000		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			16	46					0	0	0	0
MCC	4163	broad.mit.edu	37	5	112458453	112458453	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:112458453G>A	uc003kqj.3	-	4	915	c.385C>T	c.(385-387)CGA>TGA	p.R129*	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Nonsense_Mutation_p.R319*|MCC_uc011cwb.1_Nonsense_Mutation_p.R129*|MCC_uc010jcd.1_Nonsense_Mutation_p.R91*	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	129					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TCCATGCTTCGAGAGTCCTCG	0.522000													6	60					0	0	0	0
SLC12A2	6558	broad.mit.edu	37	5	127420048	127420048	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:127420048A>T	uc003kus.2	+	1	566	c.402A>T	c.(400-402)GAA>GAT	p.E134D	FLJ33630_uc003kun.2_5'Flank|FLJ33630_uc003kuo.2_5'Flank|FLJ33630_uc003kup.1_5'Flank|FLJ33630_uc003kuq.1_5'Flank|FLJ33630_uc003kur.2_5'Flank|SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.E134D	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	134	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCAGCGAGGAAGCCAAGGGCC	0.637000													3	9					0	0	0	0
NEUROG1	4762	broad.mit.edu	37	5	134870804	134870804	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:134870804C>T	uc003lax.2	-	1	836	c.577G>A	c.(577-579)GCC>ACC	p.A193T		NM_006161	NP_006152	Q92886	NGN1_HUMAN	neurogenin 1	193					positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCGGGGAGGCGGCGGCGGCA	0.721000													14	32					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167198	140167198	+	Silent	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:140167198G>T	uc003lhb.2	+	1	1323	c.1323G>T	c.(1321-1323)GTG>GTT	p.V441V	PCDHA1_uc003lha.2_Silent_p.V441V|PCDHA1_uc003lgz.2_Silent_p.V441V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	441	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCAGGGTGTCCGTGGAGG	0.662000													7	124					1.12685e-05	1.20501e-05	1	0
TFAP2A	7020	broad.mit.edu	37	6	10404781	10404781	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:10404781C>T	uc003myr.2	-	4	976	c.724G>A	c.(724-726)GAG>AAG	p.E242K	TFAP2A_uc003myq.2_Missense_Mutation_p.E236K|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.E242K|TFAP2A_uc003myt.2_Missense_Mutation_p.E238K|TFAP2A_uc003myu.1_Missense_Mutation_p.E242K	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	242					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TTGAGACACTCGGGTGGTGAG	0.507000													6	11					0	0	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778584	31778584	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:31778584T>C	uc003nxh.2	-	2	1349	c.1166A>G	c.(1165-1167)AAG>AGG	p.K389R	HSPA1L_uc010jte.2_Missense_Mutation_p.K389R	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	389					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						GTCCTGTACCTTCTCAGACTT	0.587000													16	71					0	0	0	0
EPHA7	2045	broad.mit.edu	37	6	94120846	94120846	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:94120846G>A	uc003poe.2	-	3	446	c.205C>T	c.(205-207)CGA>TGA	p.R69*	EPHA7_uc003pof.2_Nonsense_Mutation_p.R69*|EPHA7_uc011eac.1_Nonsense_Mutation_p.R69*|EPHA7_uc003pog.3_Nonsense_Mutation_p.R69*	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	69	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R69Q(1)		lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGGTATGTTCGTATCGGGGTA	0.393000													31	99					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117630083	117630083	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:117630083C>A	uc003pxp.1	-	41	6642	c.6443G>T	c.(6442-6444)GGA>GTA	p.G2148V	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2148	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AATCAGAATTCCAAAAGACCT	0.393000			T	GOPC|ROS1	glioblastoma|NSCLC								13	53					6.31663e-08	6.99746e-08	1	0
SLC2A12	154091	broad.mit.edu	37	6	134323170	134323170	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:134323170G>T	uc003qem.1	-	4	1836	c.1665C>A	c.(1663-1665)TGC>TGA	p.C555*		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	555	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GTTCCAAAGAGCATCCCTTTG	0.363000													16	67					1.3612e-06	1.49007e-06	1	0
HIVEP2	3097	broad.mit.edu	37	6	143081528	143081528	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:143081528G>T	uc003qjd.2	-	9	6640	c.5897C>A	c.(5896-5898)TCT>TAT	p.S1966Y		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1966					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GATCAACGAAGAATGTCCCAG	0.483000													35	115					4.3181e-19	5.18733e-19	1	0
SNX8	29886	broad.mit.edu	37	7	2296595	2296595	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:2296595C>G	uc003slw.2	-	10	1241	c.1198G>C	c.(1198-1200)GAG>CAG	p.E400Q		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	400					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		AGCTGCGTCTCCTGGTGCAGG	0.622000													4	29					0	0	0	0
SKAP2	8935	broad.mit.edu	37	7	26779555	26779555	+	Silent	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:26779555T>C	uc003syc.2	-	5	629	c.336A>G	c.(334-336)CAA>CAG	p.Q112Q	SKAP2_uc011jzi.1_5'UTR|SKAP2_uc011jzj.1_Silent_p.Q97Q	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	112					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						AAGGAAGGTCTTGTGCTGCAA	0.378000													11	45					0	0	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513222	50513222	+	Silent	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:50513222G>A	uc003tpc.2	-	4	2141	c.1764C>T	c.(1762-1764)CTC>CTT	p.L588L	FIGNL1_uc003tpb.2_Silent_p.L477L|FIGNL1_uc003tpd.2_Silent_p.L588L|FIGNL1_uc003tpe.2_Silent_p.L588L|FIGNL1_uc010kyy.2_Silent_p.L588L	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	588					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				CTTCTTCACTGAGGCAACACT	0.453000													15	118					0	0	0	0
SEMA3C	10512	broad.mit.edu	37	7	80439970	80439970	+	Silent	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:80439970G>A	uc003uhj.2	-	6	1057	c.495C>T	c.(493-495)CGC>CGT	p.R165R	SEMA3C_uc011kgw.1_Silent_p.R183R|SEMA3C_uc011kgx.1_Silent_p.R17R	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	165	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						TGAAAGAGCAGCGTCCTTTTC	0.353000													21	128					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82583457	82583457	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:82583457G>T	uc003uhx.2	-	5	7101	c.6812C>A	c.(6811-6813)TCT>TAT	p.S2271Y	PCLO_uc003uhv.2_Missense_Mutation_p.S2271Y|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2202					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TATGATAGAAGATGCCATATC	0.408000													25	84					6.36457e-07	7.00861e-07	1	0
ASNS	440	broad.mit.edu	37	7	97482673	97482673	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:97482673C>T	uc003uot.3	-	11	1770	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	ASNS_uc011kin.1_Missense_Mutation_p.D339N|ASNS_uc003uou.3_Missense_Mutation_p.D422N|ASNS_uc003uov.3_Missense_Mutation_p.D422N|ASNS_uc011kio.1_Missense_Mutation_p.D401N|ASNS_uc003uow.3_Missense_Mutation_p.D401N|ASNS_uc003uox.3_Missense_Mutation_p.D339N	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	422	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AATCGATGATCTAGAAATGGG	0.368000													26	69					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100682001	100682001	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:100682001G>C	uc003uxp.1	+	3	7357	c.7304G>C	c.(7303-7305)AGT>ACT	p.S2435T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2435	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTGAAGCCAGTTCATCTCCT	0.547000													22	474					0	0	0	0
RP1L1	94137	broad.mit.edu	37	8	10467546	10467546	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:10467546C>T	uc003wtc.2	-	4	4291	c.4062G>A	c.(4060-4062)GCG>GCA	p.A1354A		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1354					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		cctctaactgcgcctcttctt	0.179000													34	90					0	0	0	0
COL14A1	7373	broad.mit.edu	37	8	121210093	121210093	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:121210093G>C	uc003yox.2	+	7	901	c.636G>C	c.(634-636)TTG>TTC	p.L212F	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_Intron	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	212	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGGCACTTGAATGCATTTA	0.388000													15	119					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139696679	139696679	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:139696679G>T	uc003yvd.2	-	39	3448	c.3001C>A	c.(3001-3003)CTA>ATA	p.L1001I	COL22A1_uc011ljo.1_Missense_Mutation_p.L301I	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1001	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGTTCCTAGGGGTCCAGGG	0.488000										HNSCC(7;0.00092)			52	264					6.20943e-19	7.36375e-19	1	0
SMARCA2	6595	broad.mit.edu	37	9	2086844	2086844	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:2086844A>T	uc003zhc.2	+	18	2641	c.2542A>T	c.(2542-2544)ATG>TTG	p.M848L	SMARCA2_uc003zhd.2_Missense_Mutation_p.M848L|SMARCA2_uc010mha.2_Missense_Mutation_p.M839L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	848	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GTGGAAATACATGATAGTGGA	0.478000													26	104					0	0	0	0
RFX3	5991	broad.mit.edu	37	9	3293119	3293119	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:3293119C>T	uc003zhr.2	-	7	1001	c.689G>A	c.(688-690)AGA>AAA	p.R230K	RFX3_uc010mhd.2_Missense_Mutation_p.R230K|RFX3_uc003zhs.1_Missense_Mutation_p.R230K|RFX3_uc003zht.1_Missense_Mutation_p.R230K|RFX3_uc010mhe.1_Missense_Mutation_p.R205K	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	230	RFX-type winged-helix.				cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		AAAAATTGATCTTATTAATTT	0.408000													19	91					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5713936	5713936	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:5713936G>C	uc003zji.2	+	3	229	c.136G>C	c.(136-138)GAA>CAA	p.E46Q	KIAA1432_uc003zjh.2_Missense_Mutation_p.E46Q|KIAA1432_uc003zjl.3_Missense_Mutation_p.E46Q|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	125						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TTTTAAGGAAGAACAGTGTGC	0.393000													16	73					0	0	0	0
PTPRD	5789	broad.mit.edu	37	9	8633337	8633337	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:8633337G>T	uc003zkk.2	-	13	1043	c.332C>A	c.(331-333)ACC>AAC	p.T111N	PTPRD_uc003zkp.2_Missense_Mutation_p.T111N|PTPRD_uc003zkq.2_Missense_Mutation_p.T111N|PTPRD_uc003zkr.2_Missense_Mutation_p.T111N|PTPRD_uc003zks.2_Missense_Mutation_p.T111N|PTPRD_uc003zkl.2_Missense_Mutation_p.T111N|PTPRD_uc003zkm.2_Missense_Mutation_p.T111N|PTPRD_uc003zkn.2_Missense_Mutation_p.T111N|PTPRD_uc003zko.2_Missense_Mutation_p.T111N|PTPRD_uc003zkt.1_Missense_Mutation_p.T111N	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	111	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGTGAGTCTGGTGGATACACT	0.423000										TSP Lung(15;0.13)			34	108					6.97489e-18	8.1668e-18	1	0
UNC13B	10497	broad.mit.edu	37	9	35403770	35403770	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:35403770G>A	uc003zwq.2	+	39	4808	c.4516G>A	c.(4516-4518)GAG>AAG	p.E1506K	UNC13B_uc003zwr.2_Missense_Mutation_p.E1525K|ATP8B5P_uc010mkn.1_5'Flank|ATP8B5P_uc010mko.2_5'Flank|ATP8B5P_uc010mkp.2_5'Flank|ATP8B5P_uc003zwu.2_5'Flank	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1506	C2 3.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGAGGGGCCCGAGTCCTATGA	0.552000													18	54					0	0	0	0
FRMD3	257019	broad.mit.edu	37	9	86153021	86153021	+	Silent	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:86153021C>A	uc004ams.1	-	1	328	c.126G>T	c.(124-126)TCG>TCT	p.S42S	FRMD3_uc004amr.1_Silent_p.S28S	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	42	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						AGGAGATCTCCGAGTCGTCCA	0.652000													6	30					0.00116845	0.00122126	1	0
ZNF883	169834	broad.mit.edu	37	9	115760233	115760233	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:115760233C>A	uc011lwy.1	-	5	1546	c.307G>T	c.(307-309)GAA>TAA	p.E103*		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	103	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGTTTTTTCACATTCATTA	0.378000													13	62					9.31168e-06	1.00155e-05	1	0
OR1L4	254973	broad.mit.edu	37	9	125486771	125486771	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:125486771C>G	uc004bmu.1	+	1	503	c.503C>G	c.(502-504)TCT>TGT	p.S168C		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCGCTTGTCTTTCTGTGCC	0.498000													20	305					0	0	0	0
NUP214	8021	broad.mit.edu	37	9	134010311	134010311	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:134010311A>G	uc004cag.2	+	8	969	c.858A>G	c.(856-858)ATA>ATG	p.I286M	NUP214_uc004cah.2_Missense_Mutation_p.I286M|NUP214_uc004caf.1_Missense_Mutation_p.I286M	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	286					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		ACCCAGAGATATTTGTGAACT	0.398000			T	DEK|SET|ABL1	AML|T-ALL								13	73					0	0	0	0
SETX	23064	broad.mit.edu	37	9	135140296	135140296	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:135140296T>C	uc004cbk.2	-	26	7547	c.7364A>G	c.(7363-7365)TAT>TGT	p.Y2455C	SETX_uc004cbj.2_Missense_Mutation_p.Y2103C|SETX_uc010mzt.2_Missense_Mutation_p.Y2041C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2455					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATCATGTCTATAGTTTTTGTC	0.478000													58	117					0	0	0	0
KIAA0649	9858	broad.mit.edu	37	9	138377934	138377934	+	Silent	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:138377934C>T	uc004cfr.1	+	4	2127	c.1578C>T	c.(1576-1578)AGC>AGT	p.S526S		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	526						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		GCGACAGTAGCTCCGTGGACA	0.627000													6	200					0	0	0	0
FAM123B	139285	broad.mit.edu	37	X	63411781	63411781	+	Silent	SNP	T	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:63411781T>C	uc004dvo.2	-	2	1659	c.1386A>G	c.(1384-1386)GAA>GAG	p.E462E		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	462					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						TGGGGGCGGATTCTTGCTGGT	0.547000													15	23					0	0	0	0
HDX	139324	broad.mit.edu	37	X	83599378	83599378	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:83599378G>C	uc004eek.1	-	6	1649	c.1540C>G	c.(1540-1542)CAG>GAG	p.Q514E	HDX_uc011mqv.1_Missense_Mutation_p.Q514E|HDX_uc004eel.1_Missense_Mutation_p.Q456E	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	514						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GACTCAGGCTGCTCAGAGAAA	0.448000													24	25					0	0	0	0
CPXCR1	53336	broad.mit.edu	37	X	88008565	88008565	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:88008565C>A	uc004efd.3	+	3	409	c.150C>A	c.(148-150)AAC>AAA	p.N50K	CPXCR1_uc004efc.3_Missense_Mutation_p.N50K	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	50						intracellular	zinc ion binding			ovary(3)	3						ACCCAATAAACAGGGAGCCAG	0.443000													7	7					0.00198382	0.00205031	1	0
ESX1	80712	broad.mit.edu	37	X	103498950	103498950	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:103498950C>T	uc004ely.2	-	2	449	c.391G>A	c.(391-393)GAG>AAG	p.E131K		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	131					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTGGTCCCTCAGCGGTTTGT	0.647000													4	27					0	0	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128881676	128881676	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:128881676A>G	uc004eut.1	+	7	828	c.584A>G	c.(583-585)GAG>GGG	p.E195G	XPNPEP2_uc011mum.1_Missense_Mutation_p.E195G	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	195					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						TGGGGATCAGAGAGGCCACCG	0.522000													18	35					0	0	0	0
PPCS	79717	broad.mit.edu	37	1	42925463	42925463	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:42925463delT	uc001chl.2	+	3	866	c.802delT	c.(802-804)TTTfs	p.F268fs	PPCS_uc001chk.2_Frame_Shift_Del_p.F95fs	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	268					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTCCTTTGTGTTTATTGTAAC	0.408													---	---	---							
TMEM63A	9725	broad.mit.edu	37	1	226047034	226047035	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:226047034_226047035insA	uc001hpm.1	-	15	1488_1489	c.1238_1239insT	c.(1237-1239)ATCfs	p.I413fs		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	413						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					GGAGGCCCTGGATAGAGAGGTT	0.574													---	---	---							
Unknown	0	broad.mit.edu	37	10	34255540	34255540	+	IGR	DEL	C	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:34255540delC								NRP1 (631534 upstream) : PARD3 (144558 downstream)																							ttccttccttccttccttcct	0.109													---	---	---							
Unknown	0	broad.mit.edu	37	14	86916954	86916955	+	IGR	INS	-	TGTT	TGTT			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:86916954_86916955insTGTT								FLRT2 (822685 upstream) : None (None downstream)																							gtgtgtgtgtgtgtgtgtgtgt	0.228													---	---	---							
Unknown	0	broad.mit.edu	37	15	102296030	102296032	+	5'Flank	DEL	CTC	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:102296030_102296032delCTC	uc002bxr.2	-						uc010usk.1_5'Flank|uc002bxs.2_5'Flank|uc002bxu.1_5'Flank|uc002bxv.1_5'Flank|uc002bxw.1_5'Flank|uc002bxy.1_5'Flank|uc002byb.1_5'Flank|uc002byc.2_5'Flank|uc002byh.2_5'Flank|uc002byj.2_5'Flank|uc002byl.1_5'Flank|uc010usl.1_5'Flank|uc010usn.1_5'Flank|uc002byq.2_5'Flank|uc002bys.2_RNA|uc002byv.2_5'Flank|uc002byx.3_5'Flank|uc002bza.2_5'Flank|uc002bzb.2_5'Flank|uc002bzc.1_5'Flank|uc002bzd.2_5'Flank|uc002bze.2_5'Flank|uc002bzg.2_5'Flank|uc002bzi.1_5'Flank|uc002bzj.2_5'Flank|uc002bzl.2_5'Flank|uc002bzm.2_5'Flank|uc002bzo.2_5'Flank|uc002bzp.2_5'Flank|uc002bzq.2_5'Flank|uc002bzr.2_5'Flank|uc002bzt.2_5'Flank|uc010usp.1_5'Flank|uc002bzu.2_5'Flank|uc002bzv.3_5'Flank|uc010usq.1_5'Flank|uc010usr.1_5'Flank|uc010uss.1_5'Flank|uc002bzz.2_5'Flank|uc002cab.2_5'Flank|uc002cac.2_5'Flank|uc010ust.1_5'Flank|uc002cad.2_5'Flank|uc010usu.1_5'Flank|uc002cae.2_5'Flank					DQ598276																		AGTTCATCTTCTCGGAGCTGCTG	0.596													---	---	---							
FHOD1	29109	broad.mit.edu	37	16	67271255	67271256	+	Frame_Shift_Ins	INS	-	GGAGTCC	GGAGTCC			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:67271255_67271256insGGAGTCC	uc002esl.2	-	9	991_992	c.879_880insGGACTCC	c.(877-882)TCCTTCfs	p.S293fs	FHOD1_uc010ced.2_Frame_Shift_Ins_p.S100fs|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	293_294	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACATCGTAGAAGGAGTCCTGGT	0.663													---	---	---							
ARHGEF18	23370	broad.mit.edu	37	19	7535174	7535176	+	In_Frame_Del	DEL	TCT	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:7535174_7535176delTCT	uc002mgi.2	+	19	3765_3767	c.3512_3514delTCT	c.(3511-3516)ATCTTC>ATC	p.F1173del	ARHGEF18_uc010xjm.1_In_Frame_Del_p.F1015del|ARHGEF18_uc002mgh.2_In_Frame_Del_p.F1015del|ARHGEF18_uc002mgj.1_In_Frame_Del_p.F810del	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	1173					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GAAGACGTCATCTTCTTCTAAAA	0.675													---	---	---							
FBXO11	80204	broad.mit.edu	37	2	48035326	48035327	+	Frame_Shift_Ins	INS	-	GG	GG			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:48035326_48035327insGG	uc010fbl.2	-	23	2576_2577	c.2462_2463insCC	c.(2461-2463)CCTfs	p.P821fs	FBXO11_uc002rwe.2_Frame_Shift_Ins_p.P821fs|FBXO11_uc010fbk.2_Frame_Shift_Ins_p.P329fs	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	905					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TATCATGTGTAGGCTCACCAGC	0.401													---	---	---							
Unknown	0	broad.mit.edu	37	2	234699319	234699319	+	IGR	DEL	T	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:234699319delT								UGT1A10 (17370 upstream) : HJURP (46168 downstream)																							cctccctccctcccttccttc	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	3	110203181	110203184	+	IGR	DEL	AAAG	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:110203181_110203184delAAAG								FLJ25363 (989167 upstream) : PVRL3 (587681 downstream)																							gaaaagaaacaaagaaagaaagaa	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	3	133221083	133221085	+	IGR	DEL	GAA	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:133221083_133221085delGAA								BFSP2 (27027 upstream) : CDV3 (71349 downstream)																							aggaaggaaggaaggaagggaag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	5	67107582	67107585	+	IGR	DEL	TCTT	-	-	rs71957981		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:67107582_67107585delTCTT								CD180 (614965 upstream) : PIK3R1 (404019 downstream)																							cttttctttctctttctttctttc	0.005													---	---	---							
Unknown	0	broad.mit.edu	37	5	149227268	149227268	+	IGR	DEL	A	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:149227268delA								PPARGC1B (1 upstream) : PDE6A (10252 downstream)																							GCTGTCCTTTAAAAAAAAAAA	0.413													---	---	---							
HAVCR2	84868	broad.mit.edu	37	5	156522408	156522434	+	In_Frame_Del	DEL	AGAGTCCCGTAAGTCATTGGCCAATCT	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:156522408_156522434delAGAGTCCCGTAAGTCATTGGCCAATCT	uc003lwk.1	-	5	703_729	c.559_585delAGATTGGCCAATGACTTACGGGACTCT	c.(559-585)AGATTGGCCAATGACTTACGGGACTCTdel	p.RLANDLRDS187del		NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	187_195	Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGTTGCTCCAGAGTCCCGTAAGTCATTGGCCAATCTAGAGTCCCGT	0.445													---	---	---							
TBRG4	9238	broad.mit.edu	37	7	45148633	45148634	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:45148633_45148634insA	uc003tmv.2	-	2	329_330	c.203_204insT	c.(202-204)ATAfs	p.I68fs	TBRG4_uc003tmu.2_5'Flank|TBRG4_uc003tmw.2_Frame_Shift_Ins_p.I68fs|TBRG4_uc003tmx.2_Frame_Shift_Ins_p.I68fs|TBRG4_uc011kcd.1_Frame_Shift_Ins_p.I79fs|SNORA5B_uc003tna.3_5'Flank	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	68					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CCTGCTTCTCTATGTAGGGAGT	0.554													---	---	---							
NSUN5P2	260294	broad.mit.edu	37	7	72420460	72420461	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:72420460_72420461insC	uc003twn.2	-	7	839_840	c.127_128insG	c.(127-129)GCTfs	p.A43fs	POM121_uc010lam.1_3'UTR|NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_Frame_Shift_Ins_p.A43fs|NSUN5P2_uc003two.2_Frame_Shift_Ins_p.A43fs|NSUN5P2_uc003twq.2_Frame_Shift_Ins_p.A43fs|NSUN5P2_uc010lan.1_5'UTR|NSUN5P2_uc003twp.2_Frame_Shift_Ins_p.A43fs	NM_032158	NP_115534			NOL1/NOP2/Sun domain family, member 5C isoform												0						TGACATGGGAGCCTGGCGGGGG	0.629													---	---	---							
Unknown	0	broad.mit.edu	37	8	119875749	119875750	+	IGR	DEL	AC	-	-	rs33961128		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:119875749_119875750delAC								SAMD12 (241515 upstream) : TNFRSF11B (60047 downstream)																							ctcattgtgtacacacacacac	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	8	127595687	127595688	+	IGR	INS	-	AC	AC			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:127595687_127595688insAC								FAM84B (25221 upstream) : LOC727677 (706374 downstream)																							AGAACAACAATacacacacaca	0.361													---	---	---							
Unknown	0	broad.mit.edu	37	9	138016420	138016421	+	IGR	DEL	AA	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:138016420_138016421delAA								OLFM1 (3389 upstream) : KIAA0649 (355227 downstream)																							aggggaagggaagaaaggaagg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	9	138016448	138016451	+	IGR	DEL	AAGA	-	-			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:138016448_138016451delAAGA								OLFM1 (3417 upstream) : KIAA0649 (355197 downstream)																							ggaaggaaggaagaaagaaagaaa	0.000													---	---	---							
