Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
GPR153	387509	broad.mit.edu	37	1	6314150	6314150	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:6314150G>A	uc001amp.1	-	3	674	c.414C>T	c.(412-414)TCC>TCT	p.S138S		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	138	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		ACAGGATGAAGGACACCATCC	0.622													28	56					0	0	0	0
ZBTB48	3104	broad.mit.edu	37	1	6646822	6646822	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:6646822C>G	uc009vmc.1	+	5	1235	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	ZBTB48_uc001anx.2_Missense_Mutation_p.S371C|ZBTB48_uc009vmd.1_Missense_Mutation_p.S371C|ZBTB48_uc001any.1_Missense_Mutation_p.S9C	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	371	C2H2-type 3.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		CACATGGTGTCTCACACAGGG	0.632													5	16					0	0	0	0
MFN2	9927	broad.mit.edu	37	1	12062113	12062113	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:12062113G>A	uc001atn.3	+	11	1566	c.1113G>A	c.(1111-1113)GCG>GCA	p.A371A	MFN2_uc009vni.2_Silent_p.A371A	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	371	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTGCAGAGGCGGTTCGACTCA	0.587													39	72					0	0	0	0
CLCNKA	1187	broad.mit.edu	37	1	16355704	16355704	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:16355704C>T	uc001axu.2	+	12	1217	c.1137C>T	c.(1135-1137)CCC>CCT	p.P379P	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.P379P|CLCNKA_uc010obw.1_Silent_p.P336P|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_Silent_p.P26P|CLCNKA_uc010oby.1_Nonsense_Mutation_p.R109*	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	379					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CACCCTGGCCCGAGGAGCTCG	0.627													7	69					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19447699	19447699	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:19447699T>A	uc001bbi.2	-	68	10129	c.10125A>T	c.(10123-10125)AAA>AAT	p.K3375N	UBR4_uc001bbk.1_Missense_Mutation_p.K1022N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3375					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTCCTTTTCTTTTTCTTCTT	0.453													32	92					0	0	0	0
PQLC2	54896	broad.mit.edu	37	1	19644172	19644172	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:19644172A>G	uc001bby.2	+	3	353	c.1A>G	c.(1-3)ATG>GTG	p.M1V	PQLC2_uc001bbz.2_Intron|PQLC2_uc001bca.2_Missense_Mutation_p.M1V|PQLC2_uc001bcb.2_Intron|PQLC2_uc001bcc.2_5'UTR	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	1	Extracellular (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCACAGCCATGGTCTGGAA	0.647													41	99					0	0	0	0
PINK1	65018	broad.mit.edu	37	1	20971032	20971032	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:20971032C>T	uc001bdm.2	+	4	920	c.826C>T	c.(826-828)CGG>TGG	p.R276W		NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	276	Protein kinase.|Cytoplasmic (Potential).		R -> Q.		cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAACATCATCCGGGTTCTCCG	0.592													8	126					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39920720	39920720	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:39920720C>A	uc010oiu.1	+	54	16486	c.16355C>A	c.(16354-16356)CCA>CAA	p.P5452Q	MACF1_uc010ois.1_Missense_Mutation_p.P4950Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6908					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GATCAGGAGCCAATCCCGCAG	0.527													24	35					7.92952e-12	9.15293e-12	1	0
KLF17	128209	broad.mit.edu	37	1	44595384	44595384	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:44595384C>T	uc001clp.2	+	2	499	c.441C>T	c.(439-441)TTC>TTT	p.F147F	KLF17_uc009vxf.1_Silent_p.F110F	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	147					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCAGGCCCTTCGGTGGGAATC	0.562													5	50					0	0	0	0
NFIA	4774	broad.mit.edu	37	1	61920976	61920976	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:61920976C>T	uc001czw.2	+	11	1998	c.1514C>T	c.(1513-1515)TCC>TTC	p.S505F	NFIA_uc001czy.2_Missense_Mutation_p.S497F|NFIA_uc010oos.1_Missense_Mutation_p.S550F|NFIA_uc001czv.2_Silent_p.I474I|NFIA_uc001czx.2_Missense_Mutation_p.S153F|NFIA_uc009wae.2_RNA	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	505					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GTCTTCCAGTCCTGGTACCTG	0.448													4	81					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75072531	75072531	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:75072531C>A	uc001dgg.2	-	10	1462	c.1243G>T	c.(1243-1245)GAA>TAA	p.E415*	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Nonsense_Mutation_p.E209*	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	415	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGCTCTTTTCTTTCCTAGAT	0.403													6	132					0.000157383	0.000169103	1	0
CRABP2	1382	broad.mit.edu	37	1	156670775	156670775	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:156670775T>A	uc001fpr.2	-	2	277	c.140A>T	c.(139-141)GAG>GTG	p.E47V		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	47					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	AGTGTCTCCCTCCTGTTTGAT	0.537													28	37					0	0	0	0
COPA	1314	broad.mit.edu	37	1	160312934	160312934	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:160312934G>A	uc009wti.2	-	1	421	c.27C>T	c.(25-27)AGC>AGT	p.S9S	COPA_uc001fvv.3_Silent_p.S9S|COPA_uc009wtj.1_5'UTR|NCSTN_uc009wtk.1_5'Flank|NCSTN_uc001fvx.2_5'Flank|NCSTN_uc001fvy.2_5'Flank|NCSTN_uc010pjf.1_5'Flank	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	9	WD 1.				COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGACCCGCGCGCTCTTGGTCT	0.567													12	249					0	0	0	0
MYOC	4653	broad.mit.edu	37	1	171621793	171621793	+	5'Flank	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:171621793G>A	uc001ghu.2	-						MYOC_uc010pmk.1_5'UTR	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor						anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GCTCTGCTGTGCTGAGAGGTG	0.577													10	14					0	0	0	0
RC3H1	149041	broad.mit.edu	37	1	173961928	173961928	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:173961928C>A	uc001gju.3	-	1	283	c.196G>T	c.(196-198)GTG>TTG	p.V66L	RC3H1_uc010pms.1_Missense_Mutation_p.V66L|RC3H1_uc001gjv.2_Missense_Mutation_p.V66L|RC3H1_uc010pmt.1_Missense_Mutation_p.V66L	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	66					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCTGAGTTCACAGGGAGGAGC	0.393													26	31					7.01153e-11	8.00186e-11	1	0
CEP350	9857	broad.mit.edu	37	1	180010837	180010837	+	Missense_Mutation	SNP	G	A	A	rs138458512		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:180010837G>A	uc001gnt.2	+	19	4645	c.4262G>A	c.(4261-4263)CGG>CAG	p.R1421Q	CEP350_uc009wxl.2_Missense_Mutation_p.R1420Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1421						centrosome|nucleus|spindle				ovary(4)	4						CAATCACAACGGGAAGTAACT	0.438													8	19					0	0	0	0
CACNA1S	779	broad.mit.edu	37	1	201022675	201022675	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:201022675C>T	uc001gvv.2	-	30	3934	c.3707G>A	c.(3706-3708)CGC>CAC	p.R1236H		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1236	IV.|Helical; Name=S4 of repeat IV; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACGGAACAGGCGGAAGAAGGC	0.622													4	73					0	0	0	0
UPF2	26019	broad.mit.edu	37	10	11994186	11994186	+	Silent	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:11994186A>G	uc001ila.2	-	14	3387	c.2913T>C	c.(2911-2913)GAT>GAC	p.D971D	UPF2_uc001ilb.2_Silent_p.D971D|UPF2_uc001ilc.2_Silent_p.D971D|UPF2_uc009xiz.1_Silent_p.D971D	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	971	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TGTAATCTATATCAATAGGAA	0.348													38	55					0	0	0	0
CDC123	8872	broad.mit.edu	37	10	12238301	12238301	+	Silent	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:12238301A>T	uc001ill.2	+	1	341	c.57A>T	c.(55-57)CGA>CGT	p.R19R	NUDT5_uc001ilj.2_5'Flank|NUDT5_uc001ilk.2_5'Flank|CDC123_uc009xja.2_Silent_p.R19R|CDC123_uc001ilm.2_Silent_p.R19R	NM_006023	NP_006014	O75794	CD123_HUMAN	cell division cycle 123	19					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)	1						CGTTCTTCCGAGGCGTTACCA	0.572													22	48					0	0	0	0
SPAG6	9576	broad.mit.edu	37	10	22699991	22699991	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:22699991T>A	uc001iri.2	+	10	1488	c.1346T>A	c.(1345-1347)CTT>CAT	p.L449H	SPAG6_uc001irj.2_Intron|SPAG6_uc010qct.1_Missense_Mutation_p.L419H|SPAG6_uc009xkh.2_Missense_Mutation_p.L427H	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	449					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						GCTCGACGACTTTTTGTAACA	0.378													25	32					0	0	0	0
WAC	51322	broad.mit.edu	37	10	28872436	28872436	+	Splice_Site	SNP	T	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:28872436T>G	uc001iuf.2	+	4	466	c.381_splice	c.e4+2	p.A127_splice	WAC_uc001iud.2_Splice_Site_p.A82_splice|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Splice_Site_p.A82_splice|WAC_uc001iug.2_Splice_Site_p.A127_splice|WAC_uc001iuh.2_Splice_Site_p.A82_splice	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCAGATGCAGTAAGTATTATA	0.313													49	84					0	0	0	0
IPMK	253430	broad.mit.edu	37	10	60027245	60027245	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:60027245G>C	uc001jkb.2	-	1	450	c.127C>G	c.(127-129)CTC>GTC	p.L43V	CISD1_uc001jkc.3_5'Flank	NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	43						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						CAGCCGTTGAGGAAGCGGAGT	0.701													12	17					0	0	0	0
TSPAN14	81619	broad.mit.edu	37	10	82269158	82269158	+	Silent	SNP	C	T	T	rs145582053	byFrequency	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:82269158C>T	uc001kcj.3	+	5	488	c.381C>T	c.(379-381)TTC>TTT	p.F127F	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.F110F	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	127						integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			GGGAGTTCTTCGAGAGCAACA	0.582													6	51					0	0	0	0
FAM190B	54462	broad.mit.edu	37	10	86237392	86237392	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:86237392A>G	uc001kdh.1	+	9	2491	c.2297A>G	c.(2296-2298)TAT>TGT	p.Y766C	FAM190B_uc010qmd.1_Missense_Mutation_p.Y766C|FAM190B_uc001kdi.1_Translation_Start_Site|FAM190B_uc010qme.1_Missense_Mutation_p.Y193C	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	766										ovary(3)|skin(1)	4						GCTGATAAATATACCCAAACA	0.338													8	22					0	0	0	0
HTR7	3363	broad.mit.edu	37	10	92508650	92508650	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:92508650C>A	uc001kha.2	-	2	1484	c.1241G>T	c.(1240-1242)GGC>GTC	p.G414V	HTR7_uc001kgz.2_Missense_Mutation_p.G414V|HTR7_uc001khb.2_Missense_Mutation_p.G414V	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	414	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TTCATGCATGCCTGCAGCTGA	0.498													7	145					8.12818e-05	8.82738e-05	1	0
RRP12	23223	broad.mit.edu	37	10	99123620	99123620	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:99123620G>A	uc001knf.2	-	30	3697	c.3558C>T	c.(3556-3558)ATC>ATT	p.I1186I	RRP12_uc001kne.2_Silent_p.I201I|RRP12_uc009xvl.2_Silent_p.I303I|RRP12_uc009xvm.2_Silent_p.I904I|RRP12_uc010qou.1_Silent_p.I1125I|RRP12_uc009xvn.2_Silent_p.I1086I	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1186						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CATTCCTGATGATCACATCTT	0.542													5	120					0	0	0	0
HPSE2	60495	broad.mit.edu	37	10	100503694	100503694	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:100503694G>A	uc001kpn.1	-	4	790	c.730C>T	c.(730-732)CTG>TTG	p.L244L	HPSE2_uc009xwc.1_Silent_p.L234L|HPSE2_uc001kpo.1_Intron|HPSE2_uc009xwd.1_Intron	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	244					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TACTTCAACAGACTCAGGGCA	0.418													19	42					0	0	0	0
FANK1	92565	broad.mit.edu	37	10	127677183	127677183	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:127677183G>A	uc001ljh.3	+	3	359	c.255G>A	c.(253-255)CTG>CTA	p.L85L	FANK1_uc010quk.1_Silent_p.L79L|FANK1_uc009yan.2_Silent_p.L85L|FANK1_uc001lji.2_Silent_p.L79L	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	85	Fibronectin type-III.					cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GATTTCGCCTGAAGGTCACCA	0.517													8	184					0	0	0	0
DEAF1	10522	broad.mit.edu	37	11	688405	688405	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:688405A>C	uc001lqq.1	-	3	1136	c.443T>G	c.(442-444)CTG>CGG	p.L148R	DEAF1_uc009ycf.1_5'Flank	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	148					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GACGACAATCAGTGTCGCTTT	0.617													3	50					0	0	0	0
MUC6	4588	broad.mit.edu	37	11	1017190	1017190	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:1017190A>G	uc001lsw.2	-	31	5662	c.5611T>C	c.(5611-5613)TCA>CCA	p.S1871P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1871	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTTGGCATTGAGTGGATGGAG	0.577													17	516					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1261590	1261590	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:1261590C>T	uc009ycr.1	+	46	6160	c.6034C>T	c.(6034-6036)CCC>TCC	p.P2012S	MUC5B_uc001ltb.2_Missense_Mutation_p.P1322S|MUC5B_uc001lta.2_Missense_Mutation_p.P987S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1319					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGCCTGGGTCCCCCACTCCAC	0.617													22	37					0	0	0	0
NLRP14	338323	broad.mit.edu	37	11	7081273	7081273	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:7081273A>T	uc001mfb.1	+	9	3105	c.2782A>T	c.(2782-2784)AGC>TGC	p.S928C		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	928					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TCGGCATCCAAGCTGTAATCT	0.433													60	115					0	0	0	0
EIF4G2	1982	broad.mit.edu	37	11	10825924	10825924	+	Silent	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:10825924C>A	uc001mjc.2	-	6	810	c.393G>T	c.(391-393)CTG>CTT	p.L131L	EIF4G2_uc001mjb.2_5'UTR|EIF4G2_uc009ygf.2_5'UTR|EIF4G2_uc001mjd.2_Silent_p.L131L|EIF4G2_uc001mjf.1_5'UTR|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	131	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GCTGAGCATACAGTGAGCTAT	0.443													37	76					3.21399e-22	3.79665e-22	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137567	40137567	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:40137567T>A	uc001mxa.1	-	2	2240	c.276A>T	c.(274-276)AAA>AAT	p.K92N	LRRC4C_uc001mxc.1_Missense_Mutation_p.K88N|LRRC4C_uc001mxd.1_Missense_Mutation_p.K88N|LRRC4C_uc001mxb.1_Missense_Mutation_p.K88N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	92	LRR 1.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGCTGTTCACTTTGATGATCT	0.473													15	49					0	0	0	0
SLC6A13	6540	broad.mit.edu	37	12	336790	336790	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:336790G>A	uc001qic.1	-	8	929	c.876C>T	c.(874-876)ATC>ATT	p.I292I	SLC6A13_uc009zdj.1_Silent_p.I292I|SLC6A13_uc010sdl.1_Silent_p.I200I|SLC6A13_uc010sdm.1_Silent_p.I173I	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	292	Helical; Name=6; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ACCCAAGACAGATGGCGAAGG	0.562													6	47					0	0	0	0
NOP2	4839	broad.mit.edu	37	12	6666180	6666180	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:6666180G>C	uc001qph.1	-	16	2586	c.2406C>G	c.(2404-2406)AAC>AAG	p.N802K	IFFO1_uc001qpe.1_5'Flank|IFFO1_uc010sfe.1_5'Flank|IFFO1_uc001qpf.1_5'Flank|IFFO1_uc001qpc.1_5'Flank|IFFO1_uc001qpd.1_5'Flank|NOP2_uc009zeq.1_3'UTR|NOP2_uc001qpi.1_Missense_Mutation_p.N802K|NOP2_uc001qpj.1_Missense_Mutation_p.N231K	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	806					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						GCAGCTGGCTGTTGCCCCTGG	0.557													18	32					0	0	0	0
LPCAT3	10162	broad.mit.edu	37	12	7086775	7086775	+	Silent	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:7086775A>T	uc001qsi.2	-	10	1287	c.1173T>A	c.(1171-1173)GTT>GTA	p.V391V	EMG1_uc010sfv.1_Intron|LPCAT3_uc010sfw.1_Silent_p.V285V|LPCAT3_uc009zfp.2_RNA|LPCAT3_uc010sfx.1_RNA|LPCAT3_uc009zfq.1_Silent_p.V249V	NM_005768	NP_005759	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	391					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			ovary(1)	1						TTTCCACAATAACAATGAGGA	0.547													47	63					0	0	0	0
GALNT6	11226	broad.mit.edu	37	12	51773260	51773260	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:51773260G>A	uc001ryk.2	-	2	531	c.306C>T	c.(304-306)TTC>TTT	p.F102F	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.F102F|GALNT6_uc010snh.1_Silent_p.F102F	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	102	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCCGTTCCCAGAAGGGCTTCA	0.567													5	118					0	0	0	0
MBD6	114785	broad.mit.edu	37	12	57919712	57919712	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:57919712A>T	uc001soj.1	+	6	1185	c.961A>T	c.(961-963)AGC>TGC	p.S321C	MBD6_uc001sok.1_Missense_Mutation_p.S188C|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	321	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CTTCCTTGCTAGCAGCCTACT	0.692													15	27					0	0	0	0
ATXN2	6311	broad.mit.edu	37	12	111948230	111948230	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:111948230G>T	uc001tsj.2	-	12	2357	c.2195C>A	c.(2194-2196)GCT>GAT	p.A732D	ATXN2_uc001tsh.2_Missense_Mutation_p.A467D|ATXN2_uc001tsi.2_Missense_Mutation_p.A443D|ATXN2_uc001tsk.2_RNA	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	732	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TGCAGGACTAGCAGGCGTAGG	0.493													12	214					0.00136819	0.00144699	1	0
OAS1	4938	broad.mit.edu	37	12	113354483	113354483	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:113354483A>G	uc001tud.2	+	4	930	c.824A>G	c.(823-825)TAT>TGT	p.Y275C	OAS1_uc010syn.1_Missense_Mutation_p.Y274C|OAS1_uc010syo.1_3'UTR|OAS1_uc001tub.2_Missense_Mutation_p.Y275C|OAS1_uc001tuc.2_Missense_Mutation_p.Y275C|OAS1_uc009zwf.2_Missense_Mutation_p.Y274C	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	275					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						TGGACAAAGTATTATGACTTT	0.443													39	46					0	0	0	0
GLT1D1	144423	broad.mit.edu	37	12	129360459	129360459	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:129360459G>A	uc010tbh.1	+	2	45	c.36G>A	c.(34-36)CTG>CTA	p.L12L	GLT1D1_uc001uhx.1_Silent_p.R23R|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	Error:Variant_position_missing_in_Q96MS3_after_alignment					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TTTGATAAAGGGCCCATCTAG	0.398													55	96					0	0	0	0
EP400	57634	broad.mit.edu	37	12	132446187	132446187	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:132446187C>A	uc001ujn.2	+	1	1058	c.1023C>A	c.(1021-1023)AAC>AAA	p.N341K	EP400_uc001ujl.2_Missense_Mutation_p.N341K|EP400_uc001ujm.2_Missense_Mutation_p.N341K|EP400_uc001ujj.1_Missense_Mutation_p.N341K|EP400_uc001ujk.2_Missense_Mutation_p.N341K	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	341					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTGTGGGGAACACGGGAATGA	0.612													8	10					1.58986e-06	1.76457e-06	1	0
FNDC3A	22862	broad.mit.edu	37	13	49762701	49762701	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:49762701G>C	uc001vcm.2	+	17	2181	c.1876G>C	c.(1876-1878)GAT>CAT	p.D626H	FNDC3A_uc001vcn.2_Missense_Mutation_p.D626H|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.D552H|FNDC3A_uc001vcq.2_Missense_Mutation_p.D570H	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	626	Fibronectin type-III 4.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ACATCTTTGTGATCGACTGAA	0.393													7	171					0	0	0	0
ATP7B	540	broad.mit.edu	37	13	52536026	52536026	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:52536026C>T	uc001vfw.2	-	6	2050	c.1893G>A	c.(1891-1893)CTG>CTA	p.L631L	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Silent_p.L520L|ATP7B_uc010tgt.1_Silent_p.L631L|ATP7B_uc010tgu.1_Silent_p.L631L|ATP7B_uc010tgv.1_Silent_p.L631L|ATP7B_uc001vfv.2_5'Flank|ATP7B_uc010tgs.1_5'UTR|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	631	HMA 6.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TTCTCTGGGCCAGGGAAGCAT	0.433									Wilson_disease				12	43					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329424	88329424	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:88329424C>T	uc001vln.2	+	2	2000	c.1781C>T	c.(1780-1782)GCG>GTG	p.A594V	SLITRK5_uc010tic.1_Missense_Mutation_p.A353V	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	594	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATCTGTAAGGCGCCCAAAAAA	0.532													23	136					0	0	0	0
TMTC4	84899	broad.mit.edu	37	13	101287320	101287320	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:101287320C>T	uc001vou.2	-	10	1435	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	TMTC4_uc001vot.2_Silent_p.L444L|TMTC4_uc010tja.1_Silent_p.L314L|TMTC4_uc001vov.1_Silent_p.L170L|TMTC4_uc001vow.1_Silent_p.L208L	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	425	Helical; (Potential).					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ATCCAAAAGTCAGCAGCACAC	0.527													24	40					0	0	0	0
Unknown	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:19857036A>G	uc001vvq.1	-	5		c.494T>C								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		CTGGATAATAAAGTTCATCTC	0.373													4	114					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23451169	23451169	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:23451169G>A	uc001whz.2	-	1	683	c.307C>T	c.(307-309)CAG>TAG	p.Q103*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	103	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GGCAACGACTGAGGTAGAGGC	0.706													7	1					0	0	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36103939	36103939	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:36103939C>A	uc001wti.2	-	32	4709	c.4318G>T	c.(4318-4320)GCT>TCT	p.A1440S	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.A1440S|RALGAPA1_uc010tpv.1_Missense_Mutation_p.A1453S|RALGAPA1_uc010tpw.1_Missense_Mutation_p.A1487S	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1440	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AAACACTGAGCTCCATAAACA	0.343													7	45					5.18039e-06	5.68717e-06	1	0
PSMC6	5706	broad.mit.edu	37	14	53177865	53177865	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:53177865T>A	uc010tqx.1	+	5	347	c.347T>A	c.(346-348)ATG>AAG	p.M116K	PSMC6_uc010tqw.1_Missense_Mutation_p.M82K	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	102					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					GCTTTGGATATGACTACACTA	0.328													49	31					0	0	0	0
TRIP11	9321	broad.mit.edu	37	14	92471192	92471192	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:92471192G>C	uc001xzy.2	-	11	3916	c.3128C>G	c.(3127-3129)ACT>AGT	p.T1043S	TRIP11_uc010auf.1_Missense_Mutation_p.T779S	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1043	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		AATCTGTTTAGTTAAAGATAT	0.318			T	PDGFRB	AML								23	35					0	0	0	0
LOC646214	646214	broad.mit.edu	37	15	21937040	21937040	+	RNA	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:21937040G>A	uc010tzj.1	-	1		c.3700C>T				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						TGTCTCTGTGGATCACTTGAT	0.458													25	121					0	0	0	0
CEP152	22995	broad.mit.edu	37	15	49083442	49083442	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:49083442C>T	uc001zwy.2	-	8	998	c.964G>A	c.(964-966)GAA>AAA	p.E322K	CEP152_uc001zwz.2_Missense_Mutation_p.E322K|CEP152_uc001zxa.1_Missense_Mutation_p.E229K	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	322	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		ACCTGTTCTTCATTGACTTTT	0.299													17	41					0	0	0	0
WDR72	256764	broad.mit.edu	37	15	53889439	53889439	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:53889439C>T	uc002acj.2	-	18	3027	c.2985G>A	c.(2983-2985)GCG>GCA	p.A995A		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	995										lung(1)|skin(1)	2				all cancers(107;0.0511)		GTTGAACTTCCGCCAAGAGAA	0.378													9	148					0	0	0	0
IQCH	64799	broad.mit.edu	37	15	67757466	67757466	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:67757466T>C	uc002aqo.1	+	17	2554	c.2507T>C	c.(2506-2508)GTG>GCG	p.V836A	IQCH_uc002aqq.1_Missense_Mutation_p.V493A|IQCH_uc002aqp.1_Missense_Mutation_p.V497A|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	836										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TTTAATCAGGTGTGGGCAACC	0.517													5	80					0	0	0	0
AKAP13	11214	broad.mit.edu	37	15	86201776	86201776	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:86201776G>T	uc002blv.1	+	12	4924	c.4754G>T	c.(4753-4755)CGA>CTA	p.R1585L	AKAP13_uc002blt.1_Intron|AKAP13_uc002blu.1_Intron|AKAP13_uc010bnf.1_Intron|AKAP13_uc002blw.1_Intron|AKAP13_uc010bne.1_Missense_Mutation_p.R238L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1585					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGTTCAATGCGAGTTCTTGGG	0.433													6	131					0.00307968	0.00322329	1	0
NOXO1	124056	broad.mit.edu	37	16	2030459	2030459	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:2030459C>T	uc002cnx.2	-	4	329	c.325G>A	c.(325-327)GCG>ACG	p.A109T	NOXO1_uc002cnz.2_Missense_Mutation_p.A103T|NOXO1_uc002coa.2_Missense_Mutation_p.A108T|NOXO1_uc002cny.2_Missense_Mutation_p.A104T	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	109	PX.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						TCTGCAGTCGCCAGCAGCCTC	0.682													14	24					0	0	0	0
MMP25	64386	broad.mit.edu	37	16	3100445	3100445	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:3100445G>A	uc002cth.2	+	4	796	c.559G>A	c.(559-561)GGG>AGG	p.G187R	MMP25_uc002cti.1_Missense_Mutation_p.G123R	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	187					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						CCCCTTCGACGGGTTGGGGGG	0.612													8	41					0	0	0	0
ACSM3	6296	broad.mit.edu	37	16	20781491	20781491	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:20781491C>T	uc002dhr.2	+	2	322	c.135C>T	c.(133-135)TCC>TCT	p.S45S	ACSM3_uc002dhq.2_Silent_p.S45S|ACSM3_uc010vba.1_Silent_p.S37S	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	45					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						ACTATGAATCCATGAAACAGG	0.443													31	49					0	0	0	0
LYRM1	57149	broad.mit.edu	37	16	20927015	20927015	+	Silent	SNP	G	A	A	rs138841536	by1000genomes	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:20927015G>A	uc010bwj.2	+	2	439	c.138G>A	c.(136-138)ACG>ACA	p.T46T	LYRM1_uc010bwi.1_RNA|LYRM1_uc010bwk.2_Intron|LYRM1_uc002dia.3_Silent_p.T46T|LYRM1_uc010bwl.2_Silent_p.T46T|LYRM1_uc010bwm.2_Intron|LYRM1_uc002dib.2_Silent_p.T46T	NM_020424	NP_065157	O43325	LYRM1_HUMAN	LYR motif containing 1	46						nucleus					0						AAGCCAGAACGCTGTTCCGGA	0.423													26	43					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27476145	27476145	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:27476145G>A	uc002dov.1	-	34	5408	c.5368C>T	c.(5368-5370)CAG>TAG	p.Q1790*	GTF3C1_uc002dou.2_Nonsense_Mutation_p.Q1790*	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1790						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACCTGATGCTGCTCCAGGAGG	0.677													9	17					0	0	0	0
CHST5	23563	broad.mit.edu	37	16	75564112	75564112	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:75564112G>A	uc002fei.2	-	3	1566	c.171C>T	c.(169-171)GCC>GCT	p.A57A	CHST5_uc002fej.1_Silent_p.A63A	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	57	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCTCGCCGCCGGCTGGGGATG	0.647													8	16					0	0	0	0
GSG2	83903	broad.mit.edu	37	17	3627636	3627636	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:3627636C>T	uc002fwp.2	+	1	440	c.407C>T	c.(406-408)CCG>CTG	p.P136L	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	136					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						CTCCGACTTCCGCCCTTCCCC	0.726													3	5					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577572	7577572	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:7577572T>C	uc002gim.2	-	7	903	c.709A>G	c.(709-711)ATG>GTG	p.M237V	TP53_uc002gig.1_Missense_Mutation_p.M237V|TP53_uc002gih.2_Missense_Mutation_p.M237V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M105V|TP53_uc010cng.1_Missense_Mutation_p.M105V|TP53_uc002gii.1_Missense_Mutation_p.M105V|TP53_uc010cnh.1_Missense_Mutation_p.M237V|TP53_uc010cni.1_Missense_Mutation_p.M237V|TP53_uc002gij.2_Missense_Mutation_p.M237V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M144V|TP53_uc002gio.2_Missense_Mutation_p.M105V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	237	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(97)|p.M237K(8)|p.0?(7)|p.M237V(6)|p.M237fs*10(4)|p.M237R(3)|p.M237T(2)|p.M237L(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.M237_N239delMCN(1)|p.H233fs*6(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.M237fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTACACATGTAGTTGTAG	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	54					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	39					0	0	0	0
PFAS	5198	broad.mit.edu	37	17	8170154	8170154	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:8170154C>G	uc002gkr.2	+	23	3046	c.2905C>G	c.(2905-2907)CGG>GGG	p.R969G	PFAS_uc010vuv.1_Missense_Mutation_p.R545G|PFAS_uc002gks.2_Missense_Mutation_p.R48G	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	969					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGCGTTACCGGGATGCTGG	0.662													15	28					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11648369	11648369	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:11648369A>T	uc002gne.2	+	31	6435	c.6367A>T	c.(6367-6369)AAG>TAG	p.K2123*	DNAH9_uc010coo.2_Nonsense_Mutation_p.K1417*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2123	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTGGATCTGAAGCTCCAGGC	0.512													39	73					0	0	0	0
GOSR1	9527	broad.mit.edu	37	17	28808253	28808253	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:28808253A>T	uc002hfe.2	+	2	150	c.124A>T	c.(124-126)ACC>TCC	p.T42S	GOSR1_uc002hfd.2_Missense_Mutation_p.T42S|GOSR1_uc002hff.2_5'UTR|GOSR1_uc002hfc.1_Missense_Mutation_p.T42S	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	42	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						TCATAGCAGTACCCGAGATGG	0.373													27	47					0	0	0	0
RAD51L3	5892	broad.mit.edu	37	17	33445520	33445520	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:33445520C>A	uc002hir.2	-	3	519	c.263G>T	c.(262-264)AGT>ATT	p.S88I	RFFL_uc002hiq.2_Intron|RAD51L3_uc010wcd.1_Intron|RAD51L3_uc002his.2_Intron|RAD51L3_uc010ctk.2_Translation_Start_Site|RAD51L3_uc010wce.1_5'UTR|RAD51L3_uc002hit.2_Intron|RAD51L3_uc002hiu.2_Intron|RAD51L3_uc010wcf.1_RNA|RAD51L3_uc002hiw.1_RNA|RAD51L3_uc002hiv.1_RNA|RAD51L3_uc010ctl.1_RNA|RAD51L3_uc010ctm.1_RNA	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	88					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ACACACAAACCTGCCAATGCC	0.557								Direct_reversal_of_damage|Homologous_recombination					13	93					6.72482e-11	7.71826e-11	1	0
AMAC1	146861	broad.mit.edu	37	17	33521249	33521249	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:33521249G>A	uc002hjd.2	-	1	164	c.78C>T	c.(76-78)CGC>CGT	p.R26R		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	26						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GCTGGTACCAGCGGAGGCTGG	0.652													33	41					0	0	0	0
RPL23	9349	broad.mit.edu	37	17	37008939	37008939	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:37008939C>T	uc002hqx.1	-	3	234	c.144G>A	c.(142-144)CGG>CGA	p.R48R	RPL23_uc002hqw.1_5'UTR|RPL23_uc002hqy.1_Silent_p.R48R	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	48					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						GTCTGTTCAGCCGTCCCTTGA	0.473													38	49					0	0	0	0
HEXIM1	10614	broad.mit.edu	37	17	43227082	43227082	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:43227082G>A	uc002iig.2	+	1	2399	c.525G>A	c.(523-525)AAG>AAA	p.K175K		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	175	Basic region; mediates nuclear localization and interaction with 7SK snRNA and NR3C1.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GGGAAGAGAAGAAAAAGTTCG	0.547											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	63					0	0	0	0
SNX11	29916	broad.mit.edu	37	17	46196402	46196402	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:46196402G>A	uc002inf.1	+	7	747	c.393G>A	c.(391-393)TCG>TCA	p.S131S	SNX11_uc010wlg.1_Silent_p.S123S|SNX11_uc010wlh.1_Silent_p.S123S|SNX11_uc010wli.1_Silent_p.S70S|SNX11_uc010wlj.1_5'UTR|SNX11_uc002ing.1_Silent_p.S131S|SNX11_uc002inh.1_Silent_p.S131S	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	131	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding				0						GCCAGCTCTCGGTGCCTGAGA	0.532													15	116					0	0	0	0
SLC39A6	25800	broad.mit.edu	37	18	33706965	33706965	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr18:33706965C>T	uc010dmy.2	-	2	296	c.6G>A	c.(4-6)GCG>GCA	p.A2A	SLC39A6_uc002kzj.2_Intron|ELP2_uc002kzk.1_5'Flank|ELP2_uc010xcg.1_5'Flank|ELP2_uc002kzl.1_5'Flank|ELP2_uc002kzm.1_5'Flank|ELP2_uc010xch.1_5'Flank|ELP2_uc002kzn.1_5'Flank|ELP2_uc002kzo.1_5'Flank	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	2						integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						ATAACTTCCTCGCCATTGCGC	0.383													21	44					0	0	0	0
RDH8	50700	broad.mit.edu	37	19	10127887	10127887	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:10127887G>A	uc002mmr.2	+	2	507	c.258G>A	c.(256-258)GTG>GTA	p.V86V		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	86	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	AAGTGGACGTGCTGGGTGAGA	0.587													7	13					0	0	0	0
ZNF440	126070	broad.mit.edu	37	19	11942884	11942884	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:11942884A>G	uc002msp.1	+	4	1049	c.893A>G	c.(892-894)TAT>TGT	p.Y298C		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	298	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTCCCCGTTATGTTCGTATA	0.398													21	60					0	0	0	0
C19orf2	8725	broad.mit.edu	37	19	30496290	30496290	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:30496290C>T	uc002nsr.2	+	5	420	c.390C>T	c.(388-390)GAC>GAT	p.D130D	C19orf2_uc002nsq.2_Silent_p.D112D|C19orf2_uc002nss.2_Silent_p.D90D|C19orf2_uc002nst.2_Silent_p.D54D	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	130					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CAATAGATGACTTAAAAAAAG	0.299													5	16					0	0	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643886	37643886	+	Silent	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:37643886T>C	uc002ofo.1	-	5	1146	c.915A>G	c.(913-915)AAA>AAG	p.K305K	ZNF585A_uc002ofm.1_Silent_p.K250K|ZNF585A_uc002ofn.1_Silent_p.K250K	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	305	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAATGAAGGATTTGCCACAGT	0.418													92	142					0	0	0	0
ZNF569	148266	broad.mit.edu	37	19	37903627	37903627	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:37903627G>C	uc002ogi.2	-	6	2491	c.1933C>G	c.(1933-1935)CAA>GAA	p.Q645E	ZNF569_uc002ogh.2_Missense_Mutation_p.Q486E|ZNF569_uc002ogj.2_Missense_Mutation_p.Q669E	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	645	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATGAGATTTGAGAGAAGGCT	0.433													7	115					0	0	0	0
IL28B	282617	broad.mit.edu	37	19	39735130	39735130	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:39735130T>A	uc010xut.1	-	2	189	c.185A>T	c.(184-186)GAG>GTG	p.E62V	IL28B_uc010xuu.1_Missense_Mutation_p.E62V	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	62					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CAGAAGCGACTCTTCCTAGAC	0.617													3	12					0	0	0	0
MAP3K10	4294	broad.mit.edu	37	19	40698536	40698536	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:40698536G>A	uc002ona.2	+	1	886	c.598G>A	c.(598-600)GCT>ACT	p.A200T		NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	200	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GGTCAACTGGGCTGTGCAGGT	0.622													14	15					0	0	0	0
ADCK4	79934	broad.mit.edu	37	19	41198104	41198105	+	Nonsense_Mutation	DNP	TG	AA	AA			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:41198104_41198105TG>AA	uc002oor.2	-	15	1772_1773	c.1470_1471CA>TT	c.(1468-1473)CGCAAG>CGTTAG	p.K491*	NUMBL_uc010xvq.1_5'Flank|NUMBL_uc002oon.2_5'Flank|NUMBL_uc002ooo.2_5'Flank|NUMBL_uc010xvr.1_5'Flank|ADCK4_uc002oop.1_Nonsense_Mutation_p.K168*|ADCK4_uc002ooq.1_Nonsense_Mutation_p.K450*	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	491						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CCTGCCAGCTTGCGGTGCAGGG	0.683													5	8					0	0	0	0
DEDD2	162989	broad.mit.edu	37	19	42720875	42720875	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:42720875G>A	uc002osu.1	-	2	353	c.285C>T	c.(283-285)CGC>CGT	p.R95R	DEDD2_uc002osv.1_Intron|DEDD2_uc002osw.1_Silent_p.R95R|DEDD2_uc002osx.1_Intron|DEDD2_uc002osy.1_Silent_p.R95R	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	95	DED.				activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				GCAGGTCGTGGCGGGCCAGCA	0.716													10	11					0	0	0	0
NAPA	8775	broad.mit.edu	37	19	47996260	47996260	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:47996260C>T	uc002pha.1	-	7	819	c.519G>A	c.(517-519)GCG>GCA	p.A173A	uc002pgz.1_Intron|NAPA_uc002phb.1_Silent_p.A134A|NAPA_uc002phc.1_Silent_p.A60A|NAPA_uc002phd.1_Silent_p.A173A|NAPA_uc010elf.1_Silent_p.A67A	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	173					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		GCTCCAGCAGCGCAGCGTAAC	0.642													7	87					0	0	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628589	51628589	+	Missense_Mutation	SNP	C	T	T	rs147625837		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:51628589C>T	uc002pvu.2	+	1	425	c.358C>T	c.(358-360)CGT>TGT	p.R120C	SIGLEC9_uc010yct.1_Missense_Mutation_p.R120C	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	120	Extracellular (Potential).|Ig-like V-type.	Sialic acid (By similarity).		R->K: Loss of sialic acid binding.	cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATACTTCTTTCGTATGGAGAA	0.498													24	64					0	0	0	0
ZNF530	348327	broad.mit.edu	37	19	58117075	58117075	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:58117075A>G	uc002qpk.2	+	3	402	c.182A>G	c.(181-183)GAT>GGT	p.D61G	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAGCAGTAGATGAGGGGACG	0.463													33	54					0	0	0	0
OTOF	9381	broad.mit.edu	37	2	26700047	26700047	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:26700047G>A	uc002rhk.2	-	21	2643	c.2516C>T	c.(2515-2517)GCG>GTG	p.A839V	OTOF_uc002rhh.2_Missense_Mutation_p.A92V|OTOF_uc002rhi.2_Missense_Mutation_p.A149V|OTOF_uc002rhj.2_Missense_Mutation_p.A92V	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	839	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTCGTCCGCCAGGAAGCG	0.682													3	18					0	0	0	0
QPCT	25797	broad.mit.edu	37	2	37586939	37586939	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:37586939G>A	uc002rqg.2	+	3	606	c.484G>A	c.(484-486)GTG>ATG	p.V162M	QPCT_uc002rqh.2_Missense_Mutation_p.V113M	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	162					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				TGATTCAGCCGTGCCATGTGC	0.443													39	96					0	0	0	0
BCL11A	53335	broad.mit.edu	37	2	60688292	60688292	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:60688292G>C	uc002sae.1	-	4	1983	c.1755C>G	c.(1753-1755)TGC>TGG	p.C585W	BCL11A_uc002sab.2_Missense_Mutation_p.C585W|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.C254W|BCL11A_uc010ypj.1_Missense_Mutation_p.C551W|BCL11A_uc002sad.1_Missense_Mutation_p.C433W|BCL11A_uc002saf.1_Missense_Mutation_p.C551W	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	585					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGTCTTCGTCGCAAGTGTCCC	0.682			T	IGH@	B-CLL								12	30					0	0	0	0
MTHFD2	10797	broad.mit.edu	37	2	74441326	74441326	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:74441326G>A	uc002skk.2	+	8	1089	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	SLC4A5_uc002skl.2_Intron|MTHFD2_uc002skj.2_Missense_Mutation_p.R235Q|MTHFD2_uc010yro.1_Missense_Mutation_p.R235Q|MTHFD2_uc010ffb.2_Missense_Mutation_p.R254Q|MTHFD2_uc010yrp.1_Missense_Mutation_p.R173Q	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	337					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTTGAAGAGCGAGAAGTGCTG	0.468													35	64					0	0	0	0
GGT8P	645367	broad.mit.edu	37	2	91969052	91969052	+	RNA	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:91969052T>C	uc010fho.1	+	2		c.1383T>C				NR_003503				Homo sapiens cDNA FLJ31276 fis, clone KIDNE2006376, weakly similar to GAMMA-GLUTAMYLTRANSPEPTIDASE 1 PRECURSOR (EC 2.3.2.2).												0						AAAGGTGCTTTGGGAGGGGGA	0.622													5	19					0	0	0	0
CHN1	1123	broad.mit.edu	37	2	175779816	175779816	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:175779816C>T	uc002uji.2	-	5	760	c.230G>A	c.(229-231)CGG>CAG	p.R77Q	CHN1_uc010zeq.1_Missense_Mutation_p.R77Q|CHN1_uc002ujj.2_5'UTR	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	77	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCCTGGCTGCCGCTGGCTCTC	0.463			T	TAF15	extraskeletal myxoid chondrosarcoma								3	16					0	0	0	0
CERKL	375298	broad.mit.edu	37	2	182403829	182403829	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:182403829C>T	uc002unx.2	-	13	1707	c.1606G>A	c.(1606-1608)GTC>ATC	p.V536I	CERKL_uc002uny.2_Missense_Mutation_p.V510I|CERKL_uc010zfm.1_Missense_Mutation_p.V492I|CERKL_uc002unz.2_Missense_Mutation_p.V258I|CERKL_uc002uoa.2_Missense_Mutation_p.V441I|CERKL_uc002uob.2_Missense_Mutation_p.V258I|CERKL_uc002uoc.2_Missense_Mutation_p.V397I|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.V106I	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	536					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTAATATGGACCTCTGATGCA	0.318													27	45					0	0	0	0
GULP1	51454	broad.mit.edu	37	2	189434779	189434779	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:189434779A>G	uc010fru.2	+	9	1002	c.541A>G	c.(541-543)ATG>GTG	p.M181V	GULP1_uc002uqd.2_Missense_Mutation_p.M181V|GULP1_uc010zfw.1_Missense_Mutation_p.M78V|GULP1_uc002uqf.2_Missense_Mutation_p.M181V|GULP1_uc002uqg.2_Missense_Mutation_p.M181V|GULP1_uc002uqh.1_Missense_Mutation_p.M1V	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing	181	Potential.				apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			AACAGAAAATATGGAACTTAA	0.289													14	24					0	0	0	0
SATB2	23314	broad.mit.edu	37	2	200173524	200173524	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:200173524G>A	uc002uuy.1	-	10	2516	c.1699C>T	c.(1699-1701)CGC>TGC	p.R567C	SATB2_uc010fsq.1_Missense_Mutation_p.R449C|SATB2_uc002uuz.1_Missense_Mutation_p.R567C|SATB2_uc002uva.1_Missense_Mutation_p.R567C	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	567						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTTGCATGCGTTCGCTGTGG	0.597													20	75					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216284069	216284069	+	Missense_Mutation	SNP	A	T	T	rs150405747		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:216284069A>T	uc002vfa.2	-	12	1981	c.1715T>A	c.(1714-1716)ATT>AAT	p.I572N	FN1_uc002vfb.2_Missense_Mutation_p.I572N|FN1_uc002vfc.2_Missense_Mutation_p.I572N|FN1_uc002vfd.2_Missense_Mutation_p.I572N|FN1_uc002vfe.2_Missense_Mutation_p.I572N|FN1_uc002vff.2_Missense_Mutation_p.I572N|FN1_uc002vfg.2_Missense_Mutation_p.I572N|FN1_uc002vfh.2_Missense_Mutation_p.I572N|FN1_uc002vfi.2_Missense_Mutation_p.I572N|FN1_uc002vfj.2_Missense_Mutation_p.I572N|FN1_uc002vfl.2_Missense_Mutation_p.I572N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	572	Fibronectin type-I 9.|Collagen-binding.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAATCTCCAATTTGATAAAA	0.418													14	34					0	0	0	0
STK36	27148	broad.mit.edu	37	2	219540848	219540848	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:219540848C>T	uc002viu.2	+	6	797	c.531C>T	c.(529-531)TAC>TAT	p.Y177Y	STK36_uc002viv.2_Silent_p.Y177Y	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	177	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AGCGACCATACGACCACACAG	0.532													7	132					0	0	0	0
UGT1A5	54579	broad.mit.edu	37	2	234621836	234621836	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:234621836A>G	uc002vuw.2	+	1	199	c.199A>G	c.(199-201)ATG>GTG	p.M67V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.M67V	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	67					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GGAGGTGAATATGTACATCAA	0.547													23	49					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238303780	238303780	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:238303780T>A	uc002vwl.2	-	3	444	c.159A>T	c.(157-159)GAA>GAT	p.E53D	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Missense_Mutation_p.E53D	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	53	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGGAAATGTTCCTCTCCAA	0.368													15	23					0	0	0	0
SLC23A2	9962	broad.mit.edu	37	20	4864369	4864369	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr20:4864369G>A	uc002wlg.1	-	9	1118	c.743C>T	c.(742-744)ACA>ATA	p.T248I	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Missense_Mutation_p.T248I|SLC23A2_uc002wli.2_Missense_Mutation_p.T247I	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	248	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						CACCGTGGGTGTAATGGTCAA	0.582													4	78					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29624093	29624093	+	Splice_Site	SNP	G	T	T	rs75468660		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr20:29624093G>T	uc010ztl.1	+	1	58	c.26_splice	c.e1+1	p.R9_splice	FRG1B_uc002wvm.1_Intron|FRG1B_uc010ztj.1_Intron|FRG1B_uc010gdr.1_Intron|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						CTGATTCCAGGTGAGCTTATG	0.289													5	10					0.00116845	0.00124224	1	0
GNAS	2778	broad.mit.edu	37	20	57428562	57428562	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr20:57428562T>A	uc002xzw.2	+	1	527	c.242T>A	c.(241-243)CTC>CAC	p.L81H	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TTTCAGGTCCTCAACCCGGCA	0.612			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			3	22					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41385184	41385184	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr21:41385184C>T	uc002yyq.1	-	33	6268	c.5816G>A	c.(5815-5817)CGC>CAC	p.R1939H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1939	Cytoplasmic (Potential).			HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GACCGTGGGGCGCTTCAGGGT	0.612													11	21					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47532166	47532166	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr21:47532166G>A	uc002zia.1	+	3	471	c.389G>A	c.(388-390)CGC>CAC	p.R130H	COL6A2_uc002zhy.1_Missense_Mutation_p.R130H|COL6A2_uc002zhz.1_Missense_Mutation_p.R130H|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	130	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCCTTCCGCCGCGGCACCTTC	0.672													18	28					0	0	0	0
BCR	613	broad.mit.edu	37	22	23523321	23523321	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr22:23523321C>T	uc002zww.2	+	1	770	c.174C>T	c.(172-174)TAC>TAT	p.Y58Y	BCR_uc002zwx.2_Silent_p.Y58Y	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	58	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						GCATGATCTACCTGCAGACGT	0.677			T	ABL1| FGFR1|JAK2 	CML|ALL|AML								3	8					0	0	0	0
TRMU	55687	broad.mit.edu	37	22	46748195	46748195	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr22:46748195T>C	uc003bhp.2	+	7	1104	c.740T>C	c.(739-741)ATA>ACA	p.I247T	TRMU_uc011arb.1_Missense_Mutation_p.I247T|TRMU_uc003bhq.2_Missense_Mutation_p.I29T|TRMU_uc003bhs.2_Missense_Mutation_p.I247T|TRMU_uc003bhr.2_Missense_Mutation_p.I133T|TRMU_uc003bht.2_Missense_Mutation_p.I100T|TRMU_uc003bhu.2_Missense_Mutation_p.I29T|TRMU_uc003bhv.2_Missense_Mutation_p.I100T	NM_018006	NP_060476	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate	247						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			ovary(1)	1		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		TTTATTTCCATAGAAGACAAT	0.502													85	133					0	0	0	0
NUP210	23225	broad.mit.edu	37	3	13377046	13377046	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:13377046T>C	uc003bxv.1	-	28	3834	c.3751A>G	c.(3751-3753)ACC>GCC	p.T1251A		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1251	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CTCAGCCCGGTCCGGCCTTTT	0.592													8	37					0	0	0	0
FBLN2	2199	broad.mit.edu	37	3	13679190	13679190	+	Missense_Mutation	SNP	C	T	T	rs112412824		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:13679190C>T	uc011avb.1	+	17	3451	c.3326C>T	c.(3325-3327)GCG>GTG	p.A1109V	FBLN2_uc011auz.1_Missense_Mutation_p.A1135V|FBLN2_uc011ava.1_Missense_Mutation_p.A1156V|FBLN2_uc011avc.1_Missense_Mutation_p.A1156V	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1109	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ATTGGCCCCGCGCCAGCCTTC	0.622													9	0					0	0	0	0
ANKRD28	23243	broad.mit.edu	37	3	15731669	15731669	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:15731669T>C	uc003caj.1	-	18	1873	c.1730A>G	c.(1729-1731)GAT>GGT	p.D577G	ANKRD28_uc003cai.1_Missense_Mutation_p.D423G|ANKRD28_uc011avz.1_Missense_Mutation_p.D423G|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.D607G|ANKRD28_uc003cam.2_Missense_Mutation_p.D610G	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	577	ANK 16.					nucleoplasm	protein binding			breast(1)	1						ATTTCTGACATCAAGATCTAA	0.363													2	5					0	0	0	0
IFRD2	7866	broad.mit.edu	37	3	50326350	50326350	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:50326350C>A	uc011bdp.1	-	9	1225	c.1096G>T	c.(1096-1098)GAC>TAC	p.D366Y	IFRD2_uc003czb.2_Missense_Mutation_p.D468Y	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	366							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCCTCCATGTCCTCGTAAACA	0.587													8	3					0.000157383	0.000169103	1	0
FLNB	2317	broad.mit.edu	37	3	58104676	58104676	+	Silent	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:58104676G>T	uc003djj.2	+	19	2988	c.2823G>T	c.(2821-2823)CCG>CCT	p.P941P	FLNB_uc010hne.2_Silent_p.P941P|FLNB_uc003djk.2_Silent_p.P941P|FLNB_uc010hnf.2_Silent_p.P941P|FLNB_uc003djl.2_Silent_p.P772P|FLNB_uc003djm.2_Silent_p.P772P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	941	Filamin 8.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TTGCTGCACCGCTGGATCTGA	0.517													6	47					0.00116845	0.00124224	1	0
FLNB	2317	broad.mit.edu	37	3	58111419	58111419	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:58111419G>T	uc003djj.2	+	23	4175	c.4010G>T	c.(4009-4011)GGA>GTA	p.G1337V	FLNB_uc010hne.2_Missense_Mutation_p.G1337V|FLNB_uc003djk.2_Missense_Mutation_p.G1337V|FLNB_uc010hnf.2_Missense_Mutation_p.G1337V|FLNB_uc003djl.2_Missense_Mutation_p.G1168V|FLNB_uc003djm.2_Missense_Mutation_p.G1168V	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1337	Filamin 12.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CAAGGACCTGGATTGAAAGAG	0.522													36	34					9.04072e-19	1.06176e-18	1	0
KPNA1	3836	broad.mit.edu	37	3	122145937	122145937	+	Silent	SNP	G	A	A	rs143005503		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:122145937G>A	uc003efd.1	-	14	1548	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	KPNA1_uc003efb.1_Silent_p.F303F|KPNA1_uc003efc.1_Silent_p.F303F|KPNA1_uc011bjr.1_Silent_p.F303F|KPNA1_uc010hrh.2_Silent_p.F303F|KPNA1_uc003efe.2_Silent_p.F504F	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	504	ARM 10; atypical.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		CTTCGGTCCCGAAGTAATGCT	0.438													3	57					0	0	0	0
MSL2	55167	broad.mit.edu	37	3	135870380	135870380	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:135870380G>C	uc003eqx.1	-	2	2076	c.1343C>G	c.(1342-1344)CCT>CGT	p.P448R	MSL2_uc011bmb.1_Missense_Mutation_p.P374R	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	448	Lys-rich.				histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						AGTCTTGGTAGGACTTCCTGG	0.423													37	96					0	0	0	0
PLSCR1	5359	broad.mit.edu	37	3	146251283	146251283	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:146251283G>C	uc003evx.3	-	3	456	c.68C>G	c.(67-69)CCT>CGT	p.P23R	PLSCR1_uc003evy.3_Missense_Mutation_p.P16R|PLSCR1_uc011bnn.1_Missense_Mutation_p.L15V|PLSCR1_uc003evz.3_RNA|PLSCR1_uc003ewa.2_Missense_Mutation_p.P23R	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	23	Cytoplasmic.|SH3-binding 1 (Potential).|WW-binding 1 (Potential).				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						TGGATACTGAGGAGGATACCC	0.313													46	68					0	0	0	0
AGTR1	185	broad.mit.edu	37	3	148458873	148458873	+	Silent	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:148458873T>C	uc003ewg.2	+	4	497	c.51T>C	c.(49-51)GAT>GAC	p.D17D	AGTR1_uc003ewh.2_Silent_p.D17D|AGTR1_uc003ewi.2_Silent_p.D17D|AGTR1_uc003ewj.2_Silent_p.D17D|AGTR1_uc003ewk.2_Silent_p.D17D	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	17	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TCCAAGATGATTGTCCCAAAG	0.363													28	32					0	0	0	0
IGSF10	285313	broad.mit.edu	37	3	151166715	151166715	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:151166715T>C	uc011bod.1	-	4	1054	c.1054A>G	c.(1054-1056)ATC>GTC	p.I352V		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	352					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTAGCACGATGTAGTCATTT	0.398													26	52					0	0	0	0
NLGN1	22871	broad.mit.edu	37	3	173998698	173998698	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:173998698G>T	uc003fio.1	+	7	2500	c.2077G>T	c.(2077-2079)GCC>TCC	p.A693S	NLGN1_uc003fip.1_Missense_Mutation_p.A693S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	710	Helical; (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GAACATCTTGGCCTTTGCAGC	0.463													50	68					2.27781e-18	2.65964e-18	1	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587													3	18					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195515017	195515017	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:195515017A>G	uc011bto.1	-	2	3894	c.3434T>C	c.(3433-3435)GTA>GCA	p.V1145A	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACCTGTGGATACTGAGGAAGT	0.562													2	1					0	0	0	0
HTT	3064	broad.mit.edu	37	4	3101073	3101073	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:3101073G>A	uc011bvq.1	+	4	571	c.426G>A	c.(424-426)GAG>GAA	p.E142E		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	140					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ATGACGCAGAGTCAGATGTCA	0.388													4	59					0	0	0	0
TLR6	10333	broad.mit.edu	37	4	38830188	38830188	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:38830188T>C	uc003gtm.2	-	1	973	c.907A>G	c.(907-909)ACA>GCA	p.T303A	TLR6_uc010ifg.1_Missense_Mutation_p.T303A	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	303	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GCTTTCAATGTCGTTTTAGAA	0.318													10	11					0	0	0	0
KIT	3815	broad.mit.edu	37	4	55594178	55594178	+	Silent	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:55594178G>T	uc010igr.2	+	13	1968	c.1881G>T	c.(1879-1881)CCG>CCT	p.P627P	KIT_uc010igs.2_Silent_p.P623P|KIT_uc010igt.1_Silent_p.P76P	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	627	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.P627L(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAATTTTAGCGAGTGCCCATT	0.433		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				36	48					3.21399e-22	3.79665e-22	1	0
EPHA5	2044	broad.mit.edu	37	4	66467472	66467472	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:66467472G>C	uc003hcy.2	-	3	990	c.797C>G	c.(796-798)TCT>TGT	p.S266C	EPHA5_uc003hcx.2_Missense_Mutation_p.S197C|EPHA5_uc003hcz.2_Missense_Mutation_p.S266C|EPHA5_uc011cah.1_Missense_Mutation_p.S266C|EPHA5_uc011cai.1_Missense_Mutation_p.S266C|EPHA5_uc003hda.2_Missense_Mutation_p.S266C	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	266	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATCGGTCACAGAATGGTTGAC	0.527										TSP Lung(17;0.13)			23	32					0	0	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68934384	68934384	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:68934384C>G	uc003hdt.1	-	7	756	c.707G>C	c.(706-708)AGC>ACC	p.S236T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	236	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ACTGATGAGGCTGGCTCCACA	0.522													5	71					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72425949	72425949	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:72425949G>T	uc003hfy.2	+	23	3194	c.3077G>T	c.(3076-3078)AGT>ATT	p.S1026I	SLC4A4_uc010iic.2_Missense_Mutation_p.S1026I|SLC4A4_uc010iib.2_Missense_Mutation_p.S942I|SLC4A4_uc003hfz.2_Missense_Mutation_p.S1026I|SLC4A4_uc003hgc.3_Missense_Mutation_p.S982I|SLC4A4_uc010iid.2_Missense_Mutation_p.S230I	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	1026	Cytoplasmic (Potential).			S->D: Loss of regulation by cAMP of the transporter stoichiometry. Shifts transporter stoichiometry from 3:1 to 2:1.|S->A: Prevents phosphorylation by PKA. Loss of regulation by cAMP of the transporter stoichiometry.		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			aagaagGGAAGTCTGGACAGT	0.323													16	25					4.7546e-09	5.36553e-09	1	0
UNC5C	8633	broad.mit.edu	37	4	96141148	96141148	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:96141148C>T	uc003htp.1	-	8	1442	c.1288G>A	c.(1288-1290)GCA>ACA	p.A430T	UNC5C_uc010ilc.1_Missense_Mutation_p.A449T|UNC5C_uc003htq.2_Missense_Mutation_p.A449T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	430	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGTCTTGCTGCCTTGATGTTC	0.383													33	79					0	0	0	0
C4orf3	401152	broad.mit.edu	37	4	120221571	120221571	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:120221571G>A	uc003icv.3	-	1	398	c.120C>T	c.(118-120)CCC>CCT	p.P40P		NM_001001701	NP_001001701	Q8WVX3	CD003_HUMAN	hypothetical protein LOC401152	40						integral to membrane					0						AGGAGTGTTTGGGAAGCCCAT	0.517													47	71					0	0	0	0
SLC6A19	340024	broad.mit.edu	37	5	1219624	1219624	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:1219624C>T	uc003jbw.3	+	10	1439	c.1383C>T	c.(1381-1383)CTC>CTT	p.L461L		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	461	Helical; Name=9; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGCAGGCCTCATCTGCCTGG	0.637													14	19					0	0	0	0
SFRS12	140890	broad.mit.edu	37	5	65458371	65458371	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:65458371C>T	uc003juo.2	+	6	1018	c.358C>T	c.(358-360)CCA>TCA	p.P120S	SFRS12_uc003jun.2_Missense_Mutation_p.P236S|SFRS12_uc010iwy.2_Missense_Mutation_p.P120S	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	120	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		AAATTCTGTACCAAGGGCCCT	0.378													9	62					0	0	0	0
EFNA5	1946	broad.mit.edu	37	5	106723440	106723440	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:106723440A>G	uc003kol.2	-	3	733	c.451T>C	c.(451-453)TGT>CGT	p.C151R		NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	151					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AGCTTTAGACAGGACCTTCTT	0.438													10	144					0	0	0	0
DPYSL3	1809	broad.mit.edu	37	5	146778660	146778660	+	Silent	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:146778660G>T	uc003lon.1	-	11	1376	c.1266C>A	c.(1264-1266)GCC>GCA	p.A422A	DPYSL3_uc003loo.2_Silent_p.A536A	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	422					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGTTCTTGGCAGAGACGA	0.512													7	90					9.70103e-10	1.1009e-09	1	0
GFPT2	9945	broad.mit.edu	37	5	179751887	179751887	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:179751887C>A	uc003mlw.1	-	8	703	c.605G>T	c.(604-606)AGC>ATC	p.S202I		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	202	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GAGCAGGGGGCTGCCTCTCCT	0.527													36	64					9.80977e-26	1.17253e-25	1	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833150	27833150	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:27833150G>C	uc003njw.2	+	1	44	c.18G>C	c.(16-18)AAG>AAC	p.K6N		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	6					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GACGCGGCAAGCAGGGAGGCA	0.582													10	122					0	0	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33400552	33400552	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:33400552C>T	uc011dri.1	+	5	673	c.478C>T	c.(478-480)CTG>TTG	p.L160L	SYNGAP1_uc003oeo.1_Silent_p.L145L|SYNGAP1_uc010juy.2_Silent_p.L145L	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	160	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TCGCCAGATCCTGCCTCGCTT	0.557													20	29					0	0	0	0
PI16	221476	broad.mit.edu	37	6	36930912	36930912	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:36930912C>T	uc003ona.2	+	5	1122	c.794C>T	c.(793-795)CCA>CTA	p.P265L	PI16_uc003omz.1_Intron|PI16_uc003onb.2_Intron|PI16_uc011dts.1_Missense_Mutation_p.P36L	NM_153370	NP_699201	Q6UXB8	PI16_HUMAN	protease inhibitor 16 precursor	265	Extracellular (Potential).					extracellular region|integral to membrane	peptidase inhibitor activity				0						ACCCAGGCCCCAACTTCCTTA	0.577													8	89					0	0	0	0
ABCC10	89845	broad.mit.edu	37	6	43406408	43406408	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:43406408C>T	uc003ouy.1	+	8	2217	c.2002C>T	c.(2002-2004)CTG>TTG	p.L668L	ABCC10_uc003ouz.1_Silent_p.L640L|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	668	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGGCTTTGGCCTGGCCACCCA	0.592													32	47					0	0	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904678	73904678	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:73904678C>T	uc003pgk.2	+	14	2687	c.2340C>T	c.(2338-2340)GTC>GTT	p.V780V	KCNQ5_uc011dyh.1_Silent_p.V799V|KCNQ5_uc011dyi.1_Silent_p.V790V|KCNQ5_uc010kat.2_Silent_p.V771V|KCNQ5_uc011dyj.1_Silent_p.V670V|KCNQ5_uc011dyk.1_Silent_p.V530V	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	780					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTTCTGACGTCACCACCTGCC	0.507													7	39					0	0	0	0
MYO6	4646	broad.mit.edu	37	6	76602328	76602328	+	Missense_Mutation	SNP	C	T	T	rs148245729		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:76602328C>T	uc003pih.1	+	28	3307	c.3028C>T	c.(3028-3030)CGG>TGG	p.R1010W	MYO6_uc003pig.1_Missense_Mutation_p.R1010W|MYO6_uc003pii.1_Missense_Mutation_p.R1010W|MYO6_uc003pij.1_5'Flank	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1010	Glu-rich.|Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GCGCAGGGACCGGGAGCTGGC	0.647													23	19					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152639352	152639352	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:152639352A>T	uc010kiw.2	-	86	17038	c.16436T>A	c.(16435-16437)TTA>TAA	p.L5479*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.L3*|SYNE1_uc003qos.3_Nonsense_Mutation_p.L3*|SYNE1_uc003qot.3_Nonsense_Mutation_p.L5408*|SYNE1_uc003qou.3_Nonsense_Mutation_p.L5479*|SYNE1_uc010kiz.2_Nonsense_Mutation_p.L1234*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5479	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTGCATCTAATTCCATTAA	0.403										HNSCC(10;0.0054)			27	19					0	0	0	0
GLCCI1	113263	broad.mit.edu	37	7	8125840	8125840	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:8125840C>T	uc003srk.2	+	8	1875	c.1316C>T	c.(1315-1317)TCG>TTG	p.S439L		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	439											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CAGCCTATCTCGGCCCCTCTC	0.388													13	221					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21627788	21627788	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:21627788G>A	uc003svc.2	+	10	1848	c.1817G>A	c.(1816-1818)TGT>TAT	p.C606Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	606	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGGATGTGTGTAAGCAACTG	0.368									Kartagener_syndrome				5	37					0	0	0	0
URGCP	55665	broad.mit.edu	37	7	43918683	43918683	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:43918683C>A	uc003tiw.2	-	6	436	c.379G>T	c.(379-381)GCT>TCT	p.A127S	URGCP_uc003tiu.2_Missense_Mutation_p.A84S|URGCP_uc003tiv.2_Missense_Mutation_p.A52S|URGCP_uc003tix.2_Missense_Mutation_p.A118S|URGCP_uc003tiy.2_Missense_Mutation_p.A84S|URGCP_uc003tiz.2_Missense_Mutation_p.A84S|URGCP_uc011kbj.1_Missense_Mutation_p.A84S	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	127					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CTGGCATCAGCATTGAGGGCC	0.547													40	70					4.0492e-12	4.70079e-12	1	0
GCK	2645	broad.mit.edu	37	7	44187278	44187278	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:44187278G>A	uc003tkl.2	-	7	1304	c.834C>T	c.(832-834)GAC>GAT	p.D278D	GCK_uc003tkh.1_5'Flank|GCK_uc003tki.1_5'Flank|GCK_uc003tkj.1_Silent_p.D277D|GCK_uc003tkk.1_Silent_p.D279D	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	278					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						CAGAGCTCTCGTCCACCAGGC	0.687													36	38					0	0	0	0
ZNF716	441234	broad.mit.edu	37	7	57522865	57522865	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:57522865A>C	uc011kdi.1	+	3	365	c.253A>C	c.(253-255)AAA>CAA	p.K85Q		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GATGGTAGCCAAACACCCAGG	0.443													7	113					0	0	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72339588	72339588	+	RNA	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:72339588G>T	uc010lal.1	-	1		c.68C>A				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						ACCAGGCCACGGTGTAATGCT	0.557													17	28					3.52763e-06	3.89389e-06	1	0
BAZ1B	9031	broad.mit.edu	37	7	72856543	72856543	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:72856543G>A	uc003tyc.2	-	19	4780	c.4435C>T	c.(4435-4437)CGA>TGA	p.R1479*		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1479					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTCTGTCTTCGTCCCCTGGAC	0.597													8	187					0	0	0	0
CYP3A5	1577	broad.mit.edu	37	7	99264261	99264261	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:99264261G>A	uc003urq.2	-	6	571	c.484C>T	c.(484-486)CGG>TGG	p.R162W	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Intron|CYP3A5_uc003urr.2_Missense_Mutation_p.R49W|CYP3A5_uc011kiy.1_Missense_Mutation_p.R152W|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	162					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TCTGCTTCCCGCCTCAAGTTT	0.493													11	191					0	0	0	0
TES	26136	broad.mit.edu	37	7	115892374	115892374	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:115892374G>A	uc003vho.2	+	6	1102	c.921G>A	c.(919-921)CTG>CTA	p.L307L	TES_uc011kmy.1_Silent_p.L65L|TES_uc003vhp.2_Silent_p.L298L|uc003vhq.1_5'Flank	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	307	LIM zinc-binding 2.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			CTTCCTAGCTGATATTCAGCA	0.348													8	58					0	0	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121616905	121616905	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:121616905G>T	uc003vjy.2	+	6	1014	c.619G>T	c.(619-621)GGG>TGG	p.G207W	PTPRZ1_uc003vjz.2_Missense_Mutation_p.G207W	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	207	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TAGTCGTTTTGGTAAGCTACT	0.353													7	57					1.12685e-05	1.2304e-05	1	0
MLL3	58508	broad.mit.edu	37	7	151874275	151874275	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:151874275C>G	uc003wla.2	-	38	8482	c.8263G>C	c.(8263-8265)GAT>CAT	p.D2755H	MLL3_uc003wkz.2_Missense_Mutation_p.D1816H|MLL3_uc003wky.2_Missense_Mutation_p.D264H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2755	Asp-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCAATGATATCAAACTCTCCT	0.358			N		medulloblastoma								9	64					0	0	0	0
C8orf58	541565	broad.mit.edu	37	8	22460089	22460089	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:22460089A>G	uc003xce.2	+	6	1031	c.919A>G	c.(919-921)AAC>GAC	p.N307D	C8orf58_uc011kzl.1_Missense_Mutation_p.N299D|C8orf58_uc003xcf.2_Intron|KIAA1967_uc003xch.2_5'Flank|KIAA1967_uc003xci.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	307										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GGTCCTGCTCAACCGGATCTG	0.662													12	27					0	0	0	0
EPHX2	2053	broad.mit.edu	37	8	27401308	27401308	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:27401308G>A	uc003xfu.2	+	17	1573	c.1492G>A	c.(1492-1494)GTG>ATG	p.V498M	EPHX2_uc010luu.2_Missense_Mutation_p.V466M|EPHX2_uc010luv.2_Missense_Mutation_p.V432M|EPHX2_uc003xfv.2_Missense_Mutation_p.V445M|EPHX2_uc010luw.2_Missense_Mutation_p.V432M	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	498	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GAAGGACTTCGTGCTCGTTCC	0.612													6	54					0	0	0	0
ELP3	55140	broad.mit.edu	37	8	27964292	27964292	+	Silent	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:27964292T>C	uc003xgo.3	+	4	469	c.321T>C	c.(319-321)AAT>AAC	p.N107N	ELP3_uc003xgn.3_Silent_p.N92N|ELP3_uc011laq.1_Silent_p.N35N|ELP3_uc011lar.1_Silent_p.N15N|ELP3_uc011las.1_Missense_Mutation_p.Y10H|ELP3_uc011lat.1_Missense_Mutation_p.Y10H	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	107					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TTACAGGAAATATATGTGTGT	0.333													24	48					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476920	110476920	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:110476920G>T	uc003yne.2	+	49	7963	c.7859G>T	c.(7858-7860)GGT>GTT	p.G2620V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2620	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTCTCAAGGTTGGTTTGGA	0.418										HNSCC(38;0.096)			112	133					2.55716e-62	3.07467e-62	1	0
MED30	90390	broad.mit.edu	37	8	118552171	118552171	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:118552171G>A	uc003yoj.2	+	4	642	c.491G>A	c.(490-492)CGA>CAA	p.R164Q	MED30_uc011lib.1_Missense_Mutation_p.R129Q	NM_080651	NP_542382	Q96HR3	MED30_HUMAN	TRAP/Mediator complex component TRAP25	164	Potential.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding				0	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			GATCAATTACGAAATCTCATC	0.318													4	41					0	0	0	0
KCNQ3	3786	broad.mit.edu	37	8	133150233	133150233	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:133150233T>A	uc003ytj.2	-	12	1824	c.1599A>T	c.(1597-1599)AAA>AAT	p.K533N	KCNQ3_uc010mdt.2_Missense_Mutation_p.K533N	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	533					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCTCCTTGAATTTTTTTTTAT	0.453													55	107					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139601575	139601575	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:139601575G>A	uc003yvd.2	-	65	5249	c.4802C>T	c.(4801-4803)CCC>CTC	p.P1601L	COL22A1_uc011ljo.1_Missense_Mutation_p.P881L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1601	Pro-rich.|Gly-rich.|Collagen-like 16.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGCCTGGGGGACCGGGAGG	0.617										HNSCC(7;0.00092)			8	39					0	0	0	0
IFNA6	3443	broad.mit.edu	37	9	21350758	21350758	+	Silent	SNP	T	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:21350758T>C	uc011lni.1	-	1	129	c.129A>G	c.(127-129)CAA>CAG	p.Q43Q		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	43					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TTCTCCTCATTTGTGCCAGGA	0.537													67	30					0	0	0	0
POLR1E	64425	broad.mit.edu	37	9	37486777	37486777	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:37486777C>T	uc003zzz.1	+	1	628	c.340C>T	c.(340-342)CCC>TCC	p.P114S	POLR1E_uc011lqj.1_Missense_Mutation_p.P52S|POLR1E_uc003zzy.1_Missense_Mutation_p.P52S|POLR1E_uc011lqk.1_5'UTR	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	114					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		TTCCACCAACCCCAGGAAGAG	0.537													6	47					0	0	0	0
Unknown	0	broad.mit.edu	37	9	68413602	68413602	+	RNA	SNP	A	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:68413602A>G	uc004aex.2	+	1		c.157A>G								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CCTTTTGCTGAAACTCTGGGG	0.602													2	1					0	0	0	0
CORO2A	7464	broad.mit.edu	37	9	100899882	100899882	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:100899882T>A	uc004ayl.2	-	3	556	c.290A>T	c.(289-291)GAG>GTG	p.E97V	CORO2A_uc004aym.2_Missense_Mutation_p.E97V	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	97	WD 1.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				GGAGGCGATCTCAAAATCATC	0.542													51	122					0	0	0	0
COL27A1	85301	broad.mit.edu	37	9	116918294	116918294	+	Splice_Site	SNP	T	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:116918294T>G	uc011lxl.1	+	1	62	c.62_splice	c.e1+2	p.G21_splice		NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor						cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						gcgcggggggTGAGTACGAAC	0.517													5	24					0	0	0	0
OR1N2	138882	broad.mit.edu	37	9	125315629	125315629	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:125315629C>T	uc011lyx.1	+	1	181	c.181C>T	c.(181-183)CTC>TTC	p.L61F		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	61	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GGGGAACCTGCTCATTATCCT	0.522													11	167					0	0	0	0
PBX3	5090	broad.mit.edu	37	9	128723127	128723127	+	Silent	SNP	C	T	T			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:128723127C>T	uc004bqb.2	+	6	1124	c.1008C>T	c.(1006-1008)TCC>TCT	p.S336S	PBX3_uc004bqc.2_Silent_p.S155S|PBX3_uc004bqd.2_Silent_p.S155S|PBX3_uc011lzw.1_Silent_p.S261S|PBX3_uc011lzx.1_Silent_p.S247S|PBX3_uc004bqe.2_Silent_p.S244S	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	336					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						CACCAAATTCCGGTGCGTACT	0.587													3	19					0	0	0	0
ZMYM3	9203	broad.mit.edu	37	X	70463731	70463732	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:70463731_70463732CC>TA	uc004dzh.1	-	21	3466_3467	c.3379_3380GG>TA	c.(3379-3381)GGT>TAT	p.G1127Y	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.G1127Y|ZMYM3_uc004dzj.1_Missense_Mutation_p.G1115Y	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1127					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					ATATCGTTCACCATTGGGCCGA	0.5													6	53					0	0	0	0
THOC2	57187	broad.mit.edu	37	X	122765598	122765598	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:122765598G>C	uc004etu.2	-	22	2454	c.2422C>G	c.(2422-2424)CAT>GAT	p.H808D	THOC2_uc011muh.1_Missense_Mutation_p.H733D	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	808					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TGGGGTGTATGAAATTCATTA	0.418													5	144					0	0	0	0
TMEM187	8269	broad.mit.edu	37	X	153248203	153248203	+	Silent	SNP	G	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:153248203G>A	uc004fjq.2	+	2	1224	c.690G>A	c.(688-690)AAG>AAA	p.K230K	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	230						integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTGGTCCAAGGTCTGTGACG	0.562													42	16					0	0	0	0
MIR606	693191	broad.mit.edu	37	10	77312183	77312184	+	5'Flank	DEL	TC	-	-	rs1367290		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:77312183_77312184delTC	hsa-mir-606|MI0003619	+																							0						tttttttttttcccccccctct	0.000													---	---	---							
NAV2	89797	broad.mit.edu	37	11	20117234	20117237	+	Frame_Shift_Del	DEL	TCTT	-	-	rs34775480	byFrequency	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:20117234_20117237delTCTT	uc001mpr.3	+	30	6303_6306	c.5942_5945delTCTT	c.(5941-5946)CTCTTTfs	p.L1981fs	NAV2_uc001mpp.2_Frame_Shift_Del_p.L1914fs|NAV2_uc009yhx.2_Frame_Shift_Del_p.L1042fs|NAV2_uc009yhz.2_Frame_Shift_Del_p.L623fs|NAV2_uc001mpu.2_Frame_Shift_Del_p.L416fs	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2037_2038						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGACCACATCTCTTTCTTATTGGC	0.461													---	---	---							
ESYT1	23344	broad.mit.edu	37	12	56532256	56532257	+	In_Frame_Ins	INS	-	TATATGGAG	TATATGGAG			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:56532256_56532257insTATATGGAG	uc001sjq.2	+	22	2456_2457	c.2406_2407insTATATGGAG	c.(2404-2409)insTATATGGAG	p.805_806insYME	ESYT1_uc001sjr.2_In_Frame_Ins_p.815_816insYME	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	805_806	C2 4.					integral to membrane		p.E805E(1)		ovary(4)|skin(1)	5						TGCTATCCATCTATATGGAGCG	0.609													---	---	---							
LOC284232	284232	broad.mit.edu	37	13	19414238	19414238	+	RNA	DEL	T	-	-	rs79550286	by1000genomes	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:19414238delT	uc010tcj.1	-	1		c.31872delA				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TTCTTCTCTATTTTTTTTGTA	0.289													---	---	---							
TMCO3	55002	broad.mit.edu	37	13	114152804	114152804	+	Frame_Shift_Del	DEL	A	-	-	rs143854308		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:114152804delA	uc001vtu.3	+	3	953	c.592delA	c.(592-594)ATAfs	p.I198fs	TMCO3_uc001vtt.3_Frame_Shift_Del_p.I198fs	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	198	Potential.					integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GGAGGAAGAGATAGAGGAACA	0.418													---	---	---							
ANGEL1	23357	broad.mit.edu	37	14	77257651	77257652	+	Frame_Shift_Ins	INS	-	GGCT	GGCT			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:77257651_77257652insGGCT	uc001xsv.2	-	8	1789_1790	c.1676_1677insAGCC	c.(1675-1677)CCTfs	p.P559fs	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	559										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TGGAGAAGGCAGGCTCAAGCTC	0.505													---	---	---							
Unknown	0	broad.mit.edu	37	15	101250575	101250580	+	IGR	DEL	GATGGA	-	-	rs111555768	by1000genomes	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:101250575_101250580delGATGGA								ASB7 (58673 upstream) : ALDH1A3 (169429 downstream)																							tggaggtcatgatggaggtggaggtg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	2	90260066	90260066	+	RNA	DEL	T	-	-			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:90260066delT	uc010fhm.2	+	30		c.4049delT								Parts of antibodies, mostly variable regions.																		TTATTTAGCCTGGTATCAGCA	0.507													---	---	---							
XIRP1	165904	broad.mit.edu	37	3	39227515	39227530	+	Frame_Shift_Del	DEL	CCATCCTGAATTGTCA	-	-			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:39227515_39227530delCCATCCTGAATTGTCA	uc003cjk.1	-	2	3628_3643	c.3407_3422delTGACAATTCAGGATGG	c.(3406-3423)GTGACAATTCAGGATGGCfs	p.V1136fs	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1136_1141							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGTGTAGATGCCATCCTGAATTGTCACCCACCCCCC	0.606													---	---	---							
TFAP2A	7020	broad.mit.edu	37	6	10410525	10410526	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:10410525_10410526insG	uc003myr.2	-	2	340_341	c.88_89insC	c.(88-90)CAGfs	p.Q30fs	TFAP2A_uc003myq.2_Frame_Shift_Ins_p.Q24fs|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Frame_Shift_Ins_p.Q30fs|TFAP2A_uc003myt.2_Frame_Shift_Ins_p.Q26fs|TFAP2A_uc003myu.1_Frame_Shift_Ins_p.Q30fs|TFAP2A_uc003myv.1_Frame_Shift_Ins_p.Q16fs|TFAP2A_uc011dii.1_Frame_Shift_Ins_p.Q26fs|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	30	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGTGCCCAGCTGGGGCAACCGT	0.614													---	---	---							
Unknown	0	broad.mit.edu	37	6	75560075	75560076	+	IGR	DEL	TT	-	-			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:75560075_75560076delTT								None (None upstream) : COL12A1 (233967 downstream)																							TACGTGTTGCTTTTTTTTTTTT	0.371													---	---	---							
Unknown	0	broad.mit.edu	37	6	160132356	160132373	+	IGR	DEL	CTCACACTGCTCTGACCT	-	-	rs79322534		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:160132356_160132373delCTCACACTGCTCTGACCT								SOD2 (18003 upstream) : WTAP (15756 downstream)																							ataaccaccactcacactgctctgacctccataaccac	0.128													---	---	---							
C8orf41	80185	broad.mit.edu	37	8	33364791	33364792	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:33364791_33364792insA	uc003xjl.3	-	3	1407_1408	c.882_883insT	c.(880-885)CATGCCfs	p.H294fs	C8orf41_uc003xjk.3_Intron|C8orf41_uc010lvv.2_Frame_Shift_Ins_p.H294fs|C8orf41_uc003xjm.3_Frame_Shift_Ins_p.H294fs|C8orf41_uc003xjn.1_Frame_Shift_Ins_p.H294fs	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	294_295							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		TTGGAAATGGCATGGTATAGGA	0.406													---	---	---							
