Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATP6V1B1	525	broad.mit.edu	37	2	71188132	71188132	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:71188132A>T	uc002shj.3	+	6	754	c.667A>T	c.(667-669)Atc>Ttc	p.I223F	ATP6V1B1_uc002shi.1_Missense_Mutation_p.I223F|ATP6V1B1_uc010fdx.3_Missense_Mutation_p.I181F	NM_001692	NP_001683	P15313	VATB1_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ATP6V1B1), mRNA.	223					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CAACTTCGCCATCGTCTTTGC	0.587000													120	97					0	0	1	0	0
LIX1	167410	broad.mit.edu	37	5	96443096	96443096	+	Nonsense_Mutation	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr5:96443096C>A	uc003kmy.4	-	2	595	c.355G>T	c.(355-357)Gaa>Taa	p.E119*		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	Homo sapiens Lix1 homolog (chicken) (LIX1), mRNA.	119										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGAACACTTTCCATAATGAAT	0.527000													28	77					1.84765e-07	1.93563e-07	1	1	0
C8orf80	389643	broad.mit.edu	37	8	27913492	27913492	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr8:27913492T>C	uc003xgm.4	-	9	1339	c.1196A>G	c.(1195-1197)gAa>gGa	p.E399G		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	Homo sapiens chromosome 8 open reading frame 80 (C8orf80), mRNA.	399						nucleus	GTP binding|GTPase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|skin(1)|stomach(1)	35		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		CTTCAGTTTTTCCTTGAGAAT	0.368000													9	18					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264856	231264856	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:231264856T>A	uc010fxm.1	+	14	1303	c.1212T>A	c.(1210-1212)gaT>gaA	p.D404E	SP140L_uc010fxo.1_Missense_Mutation_p.D176E	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	Homo sapiens SP140 nuclear body protein-like (SP140L), mRNA.	404						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						GAAACTTGGATGAGTGTGAGG	0.512000													169	144					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052133	34052133	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:34052133T>A	uc001bxm.1	-	45	7199	c.7022A>T	c.(7021-7023)cAg>cTg	p.Q2341L	CSMD2_uc001bxn.1_Missense_Mutation_p.Q2343L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	Homo sapiens CUB and Sushi multiple domains 2 (CSMD2), mRNA.	2343	Sushi 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCCTTCAAACTGCAGGTAGGT	0.493000													74	102					0	0	1	0	0
NOTO	344022	broad.mit.edu	37	2	73435601	73435601	+	Silent	SNP	T	T	C	rs17008862	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:73435601T>C	uc010yrd.2	+	1	865	c.456T>C	c.(454-456)acT>acC	p.T152T		NM_001134462	NP_001127934	A8MTQ0	NOTO_HUMAN	Homo sapiens notochord homeobox (NOTO), mRNA.	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)	2						TACAGGACACTGAGAGACAGC	0.537000													3	102					0	0	1	0	0
STAG3L2	442582	broad.mit.edu	37	7	74298939	74298939	+	RNA	SNP	G	G	C	rs142156061	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr7:74298939G>C	uc011kfj.2	-	7		c.1037C>G						P0CL84	ST3L2_HUMAN	Homo sapiens stromal antigen 3-like 2 (STAG3L2), non-coding RNA.							nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						TTTCCCCCACGCCATGCCACC	0.537000													4	181					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8809352	8809352	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr3:8809352G>T	uc003brc.3	-	2	1144	c.522C>A	c.(520-522)atC>atA	p.I174I		NM_000916	NP_000907	P30559	OXYR_HUMAN	Homo sapiens oxytocin receptor (OXTR), mRNA.	174					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GCAGAGAGAAGATGTGCACCT	0.692000													93	78					2.01383e-38	2.27201e-38	1	1	0
HIST1H2BN	8341	broad.mit.edu	37	6	27806755	27806755	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr6:27806755G>A	uc003nju.1	+	0	377	c.316G>A	c.(316-318)Gag>Aag	p.E106K	HIST1H2AK_uc003njs.3_5'Flank|HIST1H2BN_uc003njt.1_Non-coding_Transcript|HIST1H2BN_uc003njv.3_Missense_Mutation_p.E106K	NM_003520	NP_003511	Q99877	H2B1N_HUMAN	Homo sapiens histone cluster 1, H2bn (HIST1H2BN), mRNA.	106					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(3)|lung(3)|prostate(1)	8						GCTGCCAGGGGAGCTGGCCAA	0.677000													19	34					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90127013	90127013	+	Silent	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:90127013C>A	uc010cje.3	-	8	989	c.969G>T	c.(967-969)cgG>cgT	p.R323R	PRDM7_uc002fqo.3_Intron|PRDM7_uc010cjf.3_Intron|PRDM7_uc010cjg.1_Silent_p.R117R	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	Homo sapiens PR domain containing 7 (PRDM7), transcript variant 1, mRNA.	323	SET.					chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTTCATCATCCCGGGCACAGT	0.542000													91	234					1.39607e-43	1.59551e-43	1	1	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:207025366G>A	uc002vbg.1	+	2	247	c.135G>A	c.(133-135)ccG>ccA	p.P45P	NDUFS1_uc010ziq.2_5'Flank|NDUFS1_uc002vbe.3_5'Flank|NDUFS1_uc010zir.2_5'Flank|NDUFS1_uc010zis.2_5'Flank|NDUFS1_uc010zit.2_5'Flank|NDUFS1_uc010ziu.2_5'Flank|EEF1B2_uc002vbf.1_Silent_p.P45P|EEF1B2_uc002vbh.1_Silent_p.P45P|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.3_5'Flank	NM_021121	NP_066944	P24534	EF1B_HUMAN	Homo sapiens eukaryotic translation elongation factor 1 beta 2 (EEF1B2), transcript variant 2, mRNA.	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(10)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													6	186					0	0	1	0	0
LASP1	3927	broad.mit.edu	37	17	37070728	37070728	+	Splice_Site	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:37070728G>A	uc002hra.3	+	5	839	c.508_splice	c.e5+1	p.V170_splice	LASP1_uc010cvq.3_Splice_Site_p.R47_splice|LASP1_uc010wdz.2_Splice_Site_p.V114_splice	NM_006148	NP_006139	Q14847	LASP1_HUMAN	Homo sapiens LIM and SH3 protein 1 (LASP1), mRNA.	170						cortical actin cytoskeleton	SH3/SH2 adaptor activity|ion transmembrane transporter activity|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|urinary_tract(2)	9						CAGTGCCCCGGGTGAGTGCAG	0.657000			T	MLL	AML								32	33					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277121	114277121	+	Missense_Mutation	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr4:114277121C>A	uc003ibe.4	+	37	7447	c.7347C>A	c.(7345-7347)caC>caA	p.H2449Q	ANK2_uc003ibd.4_Intron|ANK2_uc003ibf.4_Intron|ANK2_uc011cgc.2_Intron|ANK2_uc003ibg.4_Intron|ANK2_uc003ibh.4_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.H2464Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	Homo sapiens ankyrin 2, neuronal (ANK2), transcript variant 1, mRNA.	2416					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTCTTCACACAAAACCCCTG	0.502000													26	43					1.04121e-07	1.10394e-07	1	1	0
PNMA3	29944	broad.mit.edu	37	X	152226011	152226011	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chrX:152226011A>G	uc022cho.1	+	0	599	c.599A>G	c.(598-600)gAa>gGa	p.E200G	PNMA3_uc004fhc.2_Missense_Mutation_p.E200G|PNMA3_uc004fhd.3_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	Homo sapiens paraneoplastic antigen MA3 (PNMA3), mRNA.	200					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					cccgagggggaaaagaggcgg	0.587000													4	55					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4872081	4872081	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:4872081T>A	uc010cku.2	-	22	4058	c.3646A>T	c.(3646-3648)Agg>Tgg	p.R1216W	SPAG7_uc002gae.3_5'Flank|SPAG7_uc002gaf.3_5'Flank|DQ588877_uc021tof.1_5'Flank|CAMTA2_uc002gag.2_Missense_Mutation_p.E1192D|CAMTA2_uc002gah.2_Missense_Mutation_p.E1193D|CAMTA2_uc002gai.2_Missense_Mutation_p.E1188D	NM_001171167	NP_001164638	O94983	CMTA2_HUMAN	Homo sapiens calmodulin binding transcription activator 2 (CAMTA2), transcript variant 4, mRNA.	0					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GGGGAAGCCCTTCCAGCTCCT	0.612000													16	49					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141352597	141352597	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr7:141352597G>C	uc003vwi.2	+	15	1313	c.1142G>C	c.(1141-1143)gGc>gCc	p.G381A		NM_018238	NP_060708	Q53H12	AGK_HUMAN	Homo sapiens acylglycerol kinase (AGK), nuclear gene encoding mitochondrial protein, mRNA.	381					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	ATP binding|NAD+ kinase activity|acylglycerol kinase activity|diacylglycerol kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					GGAGCAGGGGGCTCTTTTAGC	0.502000													71	79					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45748333	45748333	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr22:45748333G>T	uc003bgc.3	-	21	3475	c.3423C>A	c.(3421-3423)caC>caA	p.H1141Q	SMC1B_uc003bgd.3_Intron	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	Homo sapiens structural maintenance of chromosomes 1B (SMC1B), mRNA.	1141	Ala/Asp-rich (DA-box).				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding	p.H1143Q(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GACCTTACCTGTGCACAGCAA	0.443000													25	64					8.58068e-18	9.32222e-18	1	1	0
C8orf80	389643	broad.mit.edu	37	8	27913490	27913490	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr8:27913490T>G	uc003xgm.4	-	9	1341	c.1198A>C	c.(1198-1200)Aaa>Caa	p.K400Q		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	Homo sapiens chromosome 8 open reading frame 80 (C8orf80), mRNA.	400						nucleus	GTP binding|GTPase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|skin(1)|stomach(1)	35		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		ACCTTCAGTTTTTCCTTGAGA	0.373000													9	18					0	0	1	0	0
C5orf44	80006	broad.mit.edu	37	5	64956553	64956553	+	Nonsense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr5:64956553T>G	uc003jua.4	+	9	1056	c.726T>G	c.(724-726)taT>taG	p.Y242*	C5orf44_uc003jtz.4_Nonsense_Mutation_p.Y242*|C5orf44_uc010iwv.3_Nonsense_Mutation_p.Y236*|C5orf44_uc003juc.4_Nonsense_Mutation_p.Y236*	NM_001093755	NP_001087224	A5PLN9	CE044_HUMAN	Homo sapiens chromosome 5 open reading frame 44 (C5orf44), transcript variant 1, mRNA.	242										kidney(4)|large_intestine(2)|lung(1)|ovary(1)	8						CAAGAGCATATTTGCAACCAA	0.408000													61	110					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84644467	84644467	+	Silent	SNP	A	A	G	rs149512713	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr7:84644467A>G	uc003uic.3	-	13	1651	c.1611T>C	c.(1609-1611)taT>taC	p.Y537Y	SEMA3D_uc010led.3_Silent_p.Y537Y|SEMA3D_uc003uib.3_Silent_p.Y176Y	NM_152754	NP_689967	O95025	SEM3D_HUMAN	Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D), mRNA.	537	PSI.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AAGCTTTCCCATAAGTGTCGC	0.468000													6	217					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641648	36641648	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr20:36641648G>C	uc002xhl.3	-	2	780	c.571C>G	c.(571-573)Cca>Gca	p.P191A	TTI1_uc002xhm.3_Missense_Mutation_p.P191A	NM_014657	NP_055472	O43156	TTI1_HUMAN	Homo sapiens TELO2 interacting protein 1 (TTI1), mRNA.	191							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AATGACCTTGGATGGTCCTGA	0.423000													20	39					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225688235	225688235	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:225688235C>T	uc010fwz.1	-	27	3405	c.3166G>A	c.(3166-3168)Gtt>Att	p.V1056I	DOCK10_uc002vob.2_Missense_Mutation_p.V1050I	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	Homo sapiens dedicator of cytokinesis 10 (DOCK10), mRNA.	1056							GTP binding	p.V1054F(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AATCTGGCAACGCTGTGGTTT	0.413000													90	74					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85279278	85279278	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr12:85279278A>G	uc001szv.3	-	3	1003	c.510T>C	c.(508-510)tcT>tcC	p.S170S	SLC6A15_uc010sul.2_Silent_p.S63S|SLC6A15_uc001szy.3_Silent_p.S170S	NM_182767	NP_001139807	Q9H2J7	S6A15_HUMAN	Homo sapiens solute carrier family 6 (neutral amino acid transporter), member 15 (SLC6A15), transcript variant 1, mRNA.	170					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GAAAAGACTGAGAAAAATAAA	0.368000													39	110					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572781	30572781	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr6:30572781G>A	uc003nqn.1	-	10	1496	c.944C>T	c.(943-945)aCg>aTg	p.T315M	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 10 (PPP1R10), mRNA.	315	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|RNA binding|protein phosphatase inhibitor activity|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CTTGGCAGCCGTAGGTGACAG	0.468000													22	47					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58292369	58292369	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:58292369G>C	uc002ene.3	+	3	567	c.488G>C	c.(487-489)gGg>gCg	p.G163A	CCDC113_uc010vid.2_Missense_Mutation_p.G109A	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	Homo sapiens coiled-coil domain containing 113 (CCDC113), transcript variant 1, mRNA.	163						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						AAGAAGAAAGGGAGTATTTTG	0.418000													43	55					0	0	1	0	0
ANKRD34C	390616	broad.mit.edu	37	15	79587095	79587095	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr15:79587095G>A	uc002bet.3	+	1	1938	c.1469G>A	c.(1468-1470)gGc>gAc	p.G490D	ANKRD34C_uc021srm.1_Missense_Mutation_p.G490D	NM_001146341	NP_001139813			Homo sapiens ankyrin repeat domain 34C (ANKRD34C), mRNA.											endometrium(3)|kidney(1)|skin(1)	5						CTTGCTAGTGGCTTAAAATCT	0.428000													16	32					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33772567	33772567	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:33772567T>C	uc002hjk.1	-	0	463	c.133A>G	c.(133-135)Aga>Gga	p.R45G	SLFN13_uc010wch.1_Missense_Mutation_p.R45G|SLFN13_uc002hjl.2_Missense_Mutation_p.R45G|SLFN13_uc002hjm.2_5'UTR|SLFN13_uc010ctt.2_Intron	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	Homo sapiens schlafen family member 13 (SLFN13), mRNA.	45						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CGTATAACTCTCGCCCTCTCT	0.498000													37	35					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43659419	43659419	+	Missense_Mutation	SNP	G	G	T	rs80035763	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr10:43659419G>T	uc001jan.3	+	4	1421	c.1086G>T	c.(1084-1086)ttG>ttT	p.L362F		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	Homo sapiens chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2), mRNA.	362					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding	p.L362F(10)		endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GAGAGGTCTTGATGTTTTTCT	0.433000													4	100					2.56e-06	2.65035e-06	1	1	0
STXBP3	6814	broad.mit.edu	37	1	109338856	109338856	+	Splice_Site	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:109338856G>C	uc001dvy.3	+	14	1186	c.1111_splice	c.e14-1	p.D371_splice		NM_007269	NP_009200	O00186	STXB3_HUMAN	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.	371					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTCATTAAGGACCTGGCACT	0.358000													36	108					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12639471	12639471	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr19:12639471G>T	uc002mty.3	-	1	253	c.43C>A	c.(43-45)Ctt>Att	p.L15I	ZNF709_uc002mtx.4_Intron	NM_144976	NP_659413	Q8N972	ZN709_HUMAN	Homo sapiens zinc finger protein 564 (ZNF564), mRNA.	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CACTCCTCAAGTGTGAAGTTC	0.468000													15	59					5.01169e-05	5.01169e-05	1	1	0
FERMT3	83706	broad.mit.edu	37	11	63990576	63990576	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr11:63990576G>T	uc001nyl.2	+	13	1888	c.1739G>T	c.(1738-1740)cGc>cTc	p.R580L	FERMT3_uc001nym.2_Missense_Mutation_p.R576L	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	Homo sapiens fermitin family member 3 (FERMT3), transcript variant URP2LF, mRNA.	580					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding	p.R580C(1)		breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CGACTGATCCGCATCGACTTG	0.622000													51	79					1.74971e-23	1.92468e-23	1	1	0
AHRR	57491	broad.mit.edu	37	5	353963	353963	+	Silent	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr5:353963C>T	uc003jav.3	+	2	236	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L	AHRR_uc003jaw.3_Silent_p.L65L|AHRR_uc010isy.3_Intron|AHRR_uc010isz.3_Silent_p.L61L	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	Homo sapiens aryl-hydrocarbon receptor repressor (AHRR), transcript variant 1, mRNA.	65	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.L61V(2)		breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CATCTCCAAGCTGGACAAGCT	0.592000													52	92					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	171969140	171969140	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr3:171969140T>A	uc003fhy.3	+	5	771	c.599T>A	c.(598-600)aTc>aAc	p.I200N	FNDC3B_uc003fhz.4_Missense_Mutation_p.I200N|FNDC3B_uc003fia.3_Missense_Mutation_p.I131N	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	Homo sapiens fibronectin type III domain containing 3B (FNDC3B), transcript variant 1, mRNA.	200						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GACCGCCAGATCGATCGCCAG	0.463000													70	48					0	0	1	0	0
PARL	55486	broad.mit.edu	37	3	183558378	183558378	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr3:183558378A>G	uc003fmd.3	-	6	867	c.808T>C	c.(808-810)Tat>Cat	p.Y270H	PARL_uc003fme.3_Missense_Mutation_p.Y220H	NM_018622	NP_061092	Q9H300	PARL_HUMAN	Homo sapiens presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	270					proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity			endometrium(2)|large_intestine(3)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	17	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GATGGTCCATATCTTCCTGTG	0.279000													46	87					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606232	21606232	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr19:21606232A>C	uc002npw.3	+	3	890	c.771A>C	c.(769-771)agA>agC	p.R257S	ZNF493_uc002npx.3_Missense_Mutation_p.R129S|ZNF493_uc002npy.3_Missense_Mutation_p.R129S|ZNF493_uc021urq.1_Missense_Mutation_p.R129S	NM_001076678	NP_787106	Q6ZR52	ZN493_HUMAN	Homo sapiens zinc finger protein 493 (ZNF493), transcript variant 3, mRNA.	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CACATAAGAGAATTCATACTG	0.378000													32	27					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133359035	133359035	+	Silent	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr12:133359035C>T	uc001ukz.1	-	16	3871	c.3312G>A	c.(3310-3312)gaG>gaA	p.E1104E	GOLGA3_uc021rgt.1_Non-coding_Transcript|GOLGA3_uc001ula.1_Silent_p.E1104E	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Homo sapiens golgin A3 (GOLGA3), transcript variant 1, mRNA.	1104					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGTTTGACTCCTCAAGGCGTT	0.473000													4	146					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39878312	39878312	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:39878312C>T	uc009vvt.1	+	0	3137	c.2375C>T	c.(2374-2376)tCa>tTa	p.S792L	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc021olw.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	Homo sapiens KIAA0754 (KIAA0754), mRNA.	656	Ala-rich.									central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGGCATCATCAGAGGGAGGG	0.428000													15	36					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41798200	41798200	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr15:41798200G>T	uc001zoa.3	-	11	1723	c.1545C>A	c.(1543-1545)gcC>gcA	p.A515A	LTK_uc001zob.3_Silent_p.A454A|LTK_uc010ucx.1_Intron|LTK_uc010bcg.2_Silent_p.A213A	NM_002344	NP_002335	P29376	LTK_HUMAN	Homo sapiens leukocyte receptor tyrosine kinase (LTK), transcript variant 1, mRNA.	515	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CATGGCCCAGGGCTCTGCAGG	0.597000										TSP Lung(18;0.14)			50	58					3.74213e-36	4.16845e-36	1	1	0
KRT13	3860	broad.mit.edu	37	17	39661375	39661375	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:39661375T>A	uc002hwu.1	-	0	491	c.428A>T	c.(427-429)cAg>cTg	p.Q143L	KRT13_uc002hwv.1_Missense_Mutation_p.Q143L|KRT13_uc010wfr.2_Missense_Mutation_p.Q36L|KRT13_uc010cxo.3_Missense_Mutation_p.Q143L|KRT13_uc021txk.1_Missense_Mutation_p.Q36L	NM_153490	NP_705694	P13646	K1C13_HUMAN	Homo sapiens keratin 13 (KRT13), transcript variant 1, mRNA.	143	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				AGCTGGGCTCTGCTTCAGGTG	0.617000													121	73					0	0	1	0	0
KIAA0564	23078	broad.mit.edu	37	13	42185853	42185853	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr13:42185853G>C	uc001uyj.3	-	38	4806	c.4736C>G	c.(4735-4737)gCa>gGa	p.A1579G		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	Homo sapiens KIAA0564 (KIAA0564), transcript variant 1, mRNA.	1579						extracellular region	ATP binding|ATPase activity			endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(19)|lung(15)|ovary(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		ACCCAGGCCTGCCGTGTCTCT	0.522000													24	59					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172195862	172195862	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:172195862A>G	uc010zdo.2	-	3	579	c.438T>C	c.(436-438)tgT>tgC	p.C146C	METTL8_uc002ugu.4_Silent_p.C146C|METTL8_uc002ugt.4_Silent_p.C146C|METTL8_uc002ugs.4_Silent_p.C96C|METTL8_uc010zdp.2_Silent_p.C101C	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	Homo sapiens methyltransferase like 8 (METTL8), mRNA.	146							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						GCACAGTAGGACAGTGCATTC	0.368000													17	61					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56814422	56814422	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr12:56814422T>G	uc001slf.2	-	25	3327	c.3159A>C	c.(3157-3159)gaA>gaC	p.E1053D		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	Homo sapiens timeless homolog (Drosophila) (TIMELESS), mRNA.	1053					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TTTCCATGGCTTCCTCATTTT	0.507000													107	114					0	0	1	0	0
AIFM2	84883	broad.mit.edu	37	10	71874678	71874678	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr10:71874678G>A	uc010qjg.2	-	6	984	c.968C>T	c.(967-969)cCg>cTg	p.P323L	AIFM2_uc021psi.1_Missense_Mutation_p.P323L|AIFM2_uc001jqp.2_Missense_Mutation_p.P323L	NM_001198696	NP_001185625	Q9BRQ8	AIFM2_HUMAN	Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 2 (AIFM2), transcript variant 1, mRNA.	323					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|urinary_tract(2)	16						TCTCTTACCCGGCTTGTAGGC	0.547000													15	36					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113140459	113140459	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr13:113140459C>G	uc001vse.1	-	21	2759	c.2572G>C	c.(2572-2574)Gtg>Ctg	p.V858L	TUBGCP3_uc010tjq.1_Missense_Mutation_p.V848L	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	Homo sapiens tubulin, gamma complex associated protein 3 (TUBGCP3), mRNA.	858					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AACTGCTGCACGATACCCTAA	0.458000													79	91					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131735460	131735460	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr9:131735460A>G	uc004bws.1	+	11	1157	c.1135A>G	c.(1135-1137)Atg>Gtg	p.M379V		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	Homo sapiens nucleoporin 188kDa (NUP188), mRNA.	379					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						CACTGCATGCATGTGTGTCTA	0.493000													13	31					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2130440	2130440	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr19:2130440G>A	uc002lva.3	-	5	782	c.559C>T	c.(559-561)Cgg>Tgg	p.R187W	AP3D1_uc002luy.3_Intron|AP3D1_uc002luz.3_Missense_Mutation_p.R187W	NM_003938	NP_003929	O14617	AP3D1_HUMAN	Homo sapiens adaptor-related protein complex 3, delta 1 subunit (AP3D1), transcript variant 2, mRNA.	187					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	Golgi membrane|endosome membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTCAGCCGGGGAAAGGCA	0.597000													5	82					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53298675	53298675	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr12:53298675A>C	uc009zmk.1	-	1	195	c.175T>G	c.(175-177)Tcc>Gcc	p.S59A	KRT8_uc001sbd.2_Missense_Mutation_p.S31A|KRT8_uc009zml.1_Missense_Mutation_p.S31A|KRT8_uc009zmm.1_Missense_Mutation_p.S31A	NM_002273	NP_002264	P05787	K2C8_HUMAN	Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA.	31	Head.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity	p.S31A(4)		endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGATGCGGGAACCGGGCCCA	0.662000													4	65					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58292370	58292370	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:58292370G>T	uc002ene.3	+	3	568	c.489G>T	c.(487-489)ggG>ggT	p.G163G	CCDC113_uc010vid.2_Silent_p.G109G	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	Homo sapiens coiled-coil domain containing 113 (CCDC113), transcript variant 1, mRNA.	163						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						AGAAGAAAGGGAGTATTTTGG	0.413000													42	56					4.0306e-16	4.32552e-16	1	1	0
METTL8	79828	broad.mit.edu	37	2	172195861	172195861	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:172195861G>A	uc010zdo.2	-	3	580	c.439C>T	c.(439-441)Cct>Tct	p.P147S	METTL8_uc002ugu.4_Missense_Mutation_p.P147S|METTL8_uc002ugt.4_Missense_Mutation_p.P147S|METTL8_uc002ugs.4_Missense_Mutation_p.P97S|METTL8_uc010zdp.2_Missense_Mutation_p.P102S	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	Homo sapiens methyltransferase like 8 (METTL8), mRNA.	147							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						GGCACAGTAGGACAGTGCATT	0.368000													17	63					0	0	1	0	0
TIMM17B	10245	broad.mit.edu	37	X	48751030	48751030	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chrX:48751030G>C	uc004dla.2	-	7	800	c.651C>G	c.(649-651)agC>agG	p.S217R	TIMM17B_uc004dlc.2_Missense_Mutation_p.S167R	NM_001167947	NP_001161419	O60830	TI17B_HUMAN	Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast) (TIMM17B), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	167					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6						ACTGCTGATAGCTGGGGTAGC	0.632000													24	49					0	0	1	0	0
CAPN8	388743	broad.mit.edu	37	1	223717484	223717484	+	Silent	SNP	G	G	A	rs34158997	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:223717484G>A	uc009xee.2	-	15	1735	c.1647C>T	c.(1645-1647)ctC>ctT	p.L549L		NM_001143962	NP_001137434	A6NHC0	CAN8_HUMAN	Homo sapiens calpain 8 (CAPN8), mRNA.	658					proteolysis	Golgi apparatus	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(1)|endometrium(2)|prostate(1)	4						AGTTGATGCCGAGCTTGCTGC	0.572000													3	71					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:207025358A>G	uc002vbg.1	+	2	239	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	NDUFS1_uc010ziq.2_5'Flank|NDUFS1_uc002vbe.3_5'Flank|NDUFS1_uc010zir.2_5'Flank|NDUFS1_uc010zis.2_5'Flank|NDUFS1_uc010zit.2_5'Flank|NDUFS1_uc010ziu.2_5'Flank|EEF1B2_uc002vbf.1_Missense_Mutation_p.S43G|EEF1B2_uc002vbh.1_Missense_Mutation_p.S43G|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.3_5'Flank	NM_021121	NP_066944	P24534	EF1B_HUMAN	Homo sapiens eukaryotic translation elongation factor 1 beta 2 (EEF1B2), transcript variant 2, mRNA.	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(8)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													6	183					0	0	1	0	0
SCRN2	90507	broad.mit.edu	37	17	45918192	45918192	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:45918192A>G	uc002imd.3	-	1	144	c.18T>C	c.(16-18)ccT>ccC	p.P6P	SCRN2_uc002imf.3_Silent_p.P6P	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	Homo sapiens secernin 2 (SCRN2), transcript variant 1, mRNA.	6					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						ATGGGGAGTCAGGGCTCGACG	0.662000													39	151					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290624	132290624	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:132290624A>G	uc002tta.3	+	6	1041	c.989A>G	c.(988-990)aAg>aGg	p.K330R	CCDC74A_uc002ttb.3_Missense_Mutation_p.K264R|CCDC74A_uc021vpq.1_Missense_Mutation_p.R266G|CCDC74A_uc021vpr.1_Missense_Mutation_p.K327R	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	Homo sapiens coiled-coil domain containing 74A (CCDC74A), mRNA.	330										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						GTCTCCACCAAGAGCCTCTCC	0.637000													125	195					0	0	1	0	0
FAM182A	284800	broad.mit.edu	37	20	26061818	26061818	+	RNA	SNP	G	G	C	rs112101451	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr20:26061818G>C	uc010gdq.3	+	3		c.879G>C								Homo sapiens family with sequence similarity 182, member A (FAM182A), non-coding RNA.											breast(1)|endometrium(2)|kidney(1)	4						GATTTCTCCTGCTTAGAAATG	0.463000													3	74					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161482	220161482	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr2:220161482C>T	uc002vkz.3	-	15	2540	c.2299G>A	c.(2299-2301)Gcc>Acc	p.A767T	PTPRN_uc010zlc.2_Missense_Mutation_p.A677T|PTPRN_uc002vla.3_Missense_Mutation_p.A738T|MIR153-1_uc010zld.1_5'Flank	NM_002846	NP_001186693	Q16849	PTPRN_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), transcript variant 1, mRNA.	767	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		ATGGGGCTGGCGTTGATGTAA	0.607000													36	119					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871576	51871576	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr20:51871576G>A	uc002xwo.3	+	1	2466	c.1579G>A	c.(1579-1581)Gcc>Acc	p.A527T	TSHZ2_uc021wex.1_Missense_Mutation_p.A524T	NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	Homo sapiens teashirt zinc finger homeobox 2 (TSHZ2), transcript variant 1, mRNA.	527					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGTCACCACAGCCATCAACAA	0.522000													20	36					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5567473	5567473	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr7:5567473A>G	uc003sot.4	-	5	1118	c.1034T>C	c.(1033-1035)aTc>aCc	p.I345T	ACTB_uc003sor.4_Missense_Mutation_p.I223T|ACTB_uc003soq.4_Missense_Mutation_p.I223T	NM_001101	NP_001092	P60709	ACTB_HUMAN	Homo sapiens actin, beta (ACTB), mRNA.	345					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	MLL5-L complex|NuA4 histone acetyltransferase complex|cytoskeleton|cytosol|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CGAGGCCAGGATGGAGCCGCC	0.612000													174	168					0	0	1	0	0
IFNAR1	3454	broad.mit.edu	37	21	34725063	34725063	+	Splice_Site	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr21:34725063G>A	uc002yrn.3	+	9	1291	c.1144_splice	c.e9-1	p.R382_splice	IFNAR1_uc011adv.2_Splice_Site_p.R313_splice	NM_000629	NP_000620	P17181	INAR1_HUMAN	Homo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1), mRNA.	382	Fibronectin type-III 3.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	ATATTTTCTAGAGAAAAATTA	0.328000													11	4					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	839242	839242	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:839242G>T	uc002ckf.4	+	1	466	c.403G>T	c.(403-405)Gtc>Ttc	p.V135F	RPUSD1_uc002cka.3_5'Flank|RPUSD1_uc002ckb.3_5'Flank|CHTF18_uc010uus.1_Missense_Mutation_p.V107F|CHTF18_uc010bre.1_Non-coding_Transcript|CHTF18_uc002cke.4_Missense_Mutation_p.V107F|CHTF18_uc010brf.3_5'UTR|CHTF18_uc002ckg.4_Intron	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	Homo sapiens CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) (CHTF18), mRNA.	107					DNA replication|cell cycle	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				GCTGCAGGTGGTCAAGAGGCT	0.692000													96	85					2.02578e-71	2.34564e-71	1	1	0
WDR1	9948	broad.mit.edu	37	4	10099338	10099338	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr4:10099338A>G	uc021xlv.1	-	4	838	c.555T>C	c.(553-555)atT>atC	p.I185I	WDR1_uc021xlw.1_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	Homo sapiens WD repeat domain 1 (WDR1), transcript variant 1, mRNA.	185			I -> V (in dbSNP:rs13441).		platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CACTTACGCCAATTGTGAACT	0.507000													42	59					0	0	1	0	0
TIMM17B	10245	broad.mit.edu	37	X	48751031	48751031	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chrX:48751031C>T	uc004dla.2	-	7	799	c.650G>A	c.(649-651)aGc>aAc	p.S217N	TIMM17B_uc004dlc.2_Missense_Mutation_p.S167N	NM_001167947	NP_001161419	O60830	TI17B_HUMAN	Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast) (TIMM17B), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	167					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6						CTGCTGATAGCTGGGGTAGCC	0.627000													24	49					0	0	1	0	0
LOC646851	646851	broad.mit.edu	37	22	39032548	39032548	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr22:39032548T>G	uc011anw.1	-	5	1031	c.427A>C	c.(427-429)Agc>Cgc	p.S143R	LOC646851_uc011anx.1_Missense_Mutation_p.S50R	NM_001013647	NP_001013669	B7Z7C6	B7Z7C6_HUMAN	Homo sapiens putative uncharacterized protein LOC388900 (LOC646851), mRNA.	50																	GGCTTGGAGCTGTTGAAGTTG	0.478000													3	98					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18849889	18849889	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:18849889A>G	uc002dfm.3	-	42	7431	c.7068T>C	c.(7066-7068)aaT>aaC	p.N2356N	SMG1_uc010bwb.3_Silent_p.N2216N|SMG1_uc010bwa.3_Silent_p.N1087N|SMG1_uc021ted.1_Silent_p.N654N	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	Homo sapiens smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (SMG1), mRNA.	2356	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CAAAGCAAACATTGTAATCTA	0.328000													31	110					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27958364	27958364	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr17:27958364C>T	uc002heo.1	-	14	3767	c.3767G>A	c.(3766-3768)cGc>cAc	p.R1256H	SSH2_uc010wbh.1_Missense_Mutation_p.R1283H	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	Homo sapiens slingshot homolog 2 (Drosophila) (SSH2), mRNA.	1256					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGAAGCTGAGCGCCTCATTTG	0.532000													70	44					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71188132	71188132	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:71188132A>T	uc002shj.3	+	6	754	c.667A>T	c.(667-669)Atc>Ttc	p.I223F	ATP6V1B1_uc002shi.1_Missense_Mutation_p.I223F|ATP6V1B1_uc010fdx.3_Missense_Mutation_p.I181F	NM_001692	NP_001683	P15313	VATB1_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ATP6V1B1), mRNA.	223					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CAACTTCGCCATCGTCTTTGC	0.587000													120	97					0	0	1	0	0
LIX1	167410	broad.mit.edu	37	5	96443096	96443096	+	Nonsense_Mutation	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr5:96443096C>A	uc003kmy.4	-	2	595	c.355G>T	c.(355-357)Gaa>Taa	p.E119*		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	Homo sapiens Lix1 homolog (chicken) (LIX1), mRNA.	119										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGAACACTTTCCATAATGAAT	0.527000													28	77					1.84765e-07	1.9503e-07	1	1	0
C8orf80	389643	broad.mit.edu	37	8	27913492	27913492	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr8:27913492T>C	uc003xgm.4	-	9	1339	c.1196A>G	c.(1195-1197)gAa>gGa	p.E399G		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	Homo sapiens chromosome 8 open reading frame 80 (C8orf80), mRNA.	399						nucleus	GTP binding|GTPase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|skin(1)|stomach(1)	35		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		CTTCAGTTTTTCCTTGAGAAT	0.368000													9	18					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264856	231264856	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:231264856T>A	uc010fxm.1	+	14	1303	c.1212T>A	c.(1210-1212)gaT>gaA	p.D404E	SP140L_uc010fxo.1_Missense_Mutation_p.D176E	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	Homo sapiens SP140 nuclear body protein-like (SP140L), mRNA.	404						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						GAAACTTGGATGAGTGTGAGG	0.512000													169	144					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052133	34052133	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:34052133T>A	uc001bxm.1	-	45	7199	c.7022A>T	c.(7021-7023)cAg>cTg	p.Q2341L	CSMD2_uc001bxn.1_Missense_Mutation_p.Q2343L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	Homo sapiens CUB and Sushi multiple domains 2 (CSMD2), mRNA.	2343	Sushi 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCCTTCAAACTGCAGGTAGGT	0.493000													74	102					0	0	1	0	0
NOTO	344022	broad.mit.edu	37	2	73435601	73435601	+	Silent	SNP	T	T	C	rs17008862	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:73435601T>C	uc010yrd.2	+	1	865	c.456T>C	c.(454-456)acT>acC	p.T152T		NM_001134462	NP_001127934	A8MTQ0	NOTO_HUMAN	Homo sapiens notochord homeobox (NOTO), mRNA.	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)	2						TACAGGACACTGAGAGACAGC	0.537000													3	102					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8809352	8809352	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:8809352G>T	uc003brc.3	-	2	1144	c.522C>A	c.(520-522)atC>atA	p.I174I		NM_000916	NP_000907	P30559	OXYR_HUMAN	Homo sapiens oxytocin receptor (OXTR), mRNA.	174					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GCAGAGAGAAGATGTGCACCT	0.692000													93	78					2.01383e-38	2.27303e-38	1	1	0
DSPP	1834	broad.mit.edu	37	4	88536460	88536460	+	Silent	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:88536460C>T	uc003hqu.3	+	4	2766	c.2646C>T	c.(2644-2646)agC>agT	p.S882S		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	Homo sapiens dentin sialophosphoprotein (DSPP), mRNA.	882	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent	p.D881_S882insSSD(1)		breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		gcagtgatagcagtgacagca	0.498000													26	256					0	0	1	0	0
HIST1H2BN	8341	broad.mit.edu	37	6	27806755	27806755	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr6:27806755G>A	uc003nju.1	+	0	377	c.316G>A	c.(316-318)Gag>Aag	p.E106K	HIST1H2AK_uc003njs.3_5'Flank|HIST1H2BN_uc003njt.1_Non-coding_Transcript|HIST1H2BN_uc003njv.3_Missense_Mutation_p.E106K	NM_003520	NP_003511	Q99877	H2B1N_HUMAN	Homo sapiens histone cluster 1, H2bn (HIST1H2BN), mRNA.	106					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(3)|lung(3)|prostate(1)	8						GCTGCCAGGGGAGCTGGCCAA	0.677000													19	34					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90127013	90127013	+	Silent	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:90127013C>A	uc010cje.3	-	8	989	c.969G>T	c.(967-969)cgG>cgT	p.R323R	PRDM7_uc002fqo.3_Intron|PRDM7_uc010cjf.3_Intron|PRDM7_uc010cjg.1_Silent_p.R117R	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	Homo sapiens PR domain containing 7 (PRDM7), transcript variant 1, mRNA.	323	SET.					chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTTCATCATCCCGGGCACAGT	0.542000													91	234					1.39607e-43	1.59152e-43	1	1	0
CHTF18	63922	broad.mit.edu	37	16	839242	839242	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:839242G>T	uc002ckf.4	+	1	466	c.403G>T	c.(403-405)Gtc>Ttc	p.V135F	RPUSD1_uc002cka.3_5'Flank|RPUSD1_uc002ckb.3_5'Flank|CHTF18_uc010uus.1_Missense_Mutation_p.V107F|CHTF18_uc010bre.1_Non-coding_Transcript|CHTF18_uc002cke.4_Missense_Mutation_p.V107F|CHTF18_uc010brf.3_5'UTR|CHTF18_uc002ckg.4_Intron	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	Homo sapiens CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) (CHTF18), mRNA.	107					DNA replication|cell cycle	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				GCTGCAGGTGGTCAAGAGGCT	0.692000													96	85					2.02578e-71	2.33272e-71	1	1	0
LASP1	3927	broad.mit.edu	37	17	37070728	37070728	+	Splice_Site	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:37070728G>A	uc002hra.3	+	5	839	c.508_splice	c.e5+1	p.V170_splice	LASP1_uc010cvq.3_Splice_Site_p.R47_splice|LASP1_uc010wdz.2_Splice_Site_p.V114_splice	NM_006148	NP_006139	Q14847	LASP1_HUMAN	Homo sapiens LIM and SH3 protein 1 (LASP1), mRNA.	170						cortical actin cytoskeleton	SH3/SH2 adaptor activity|ion transmembrane transporter activity|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|urinary_tract(2)	9						CAGTGCCCCGGGTGAGTGCAG	0.657000			T	MLL	AML								32	33					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277121	114277121	+	Missense_Mutation	SNP	C	C	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:114277121C>A	uc003ibe.4	+	37	7447	c.7347C>A	c.(7345-7347)caC>caA	p.H2449Q	ANK2_uc003ibd.4_Intron|ANK2_uc003ibf.4_Intron|ANK2_uc011cgc.2_Intron|ANK2_uc003ibg.4_Intron|ANK2_uc003ibh.4_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.H2464Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	Homo sapiens ankyrin 2, neuronal (ANK2), transcript variant 1, mRNA.	2416					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTCTTCACACAAAACCCCTG	0.502000													26	43					1.04121e-07	1.10933e-07	1	1	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643075	1643075	+	Silent	SNP	A	A	G	rs1715357		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr11:1643075A>G	uc009ycy.1	-	1	231	c.144T>C	c.(142-144)tcT>tcC	p.S48S	MOB2_uc001ltq.2_Intron	NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	Homo sapiens keratin associated protein 5-4 (KRTAP5-4), mRNA.	143						keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AACCCCCACAAGAGCCATAGC	0.662000													4	49					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4872081	4872081	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:4872081T>A	uc010cku.2	-	22	4058	c.3646A>T	c.(3646-3648)Agg>Tgg	p.R1216W	SPAG7_uc002gae.3_5'Flank|SPAG7_uc002gaf.3_5'Flank|DQ588877_uc021tof.1_5'Flank|CAMTA2_uc002gag.2_Missense_Mutation_p.E1192D|CAMTA2_uc002gah.2_Missense_Mutation_p.E1193D|CAMTA2_uc002gai.2_Missense_Mutation_p.E1188D	NM_001171167	NP_001164638	O94983	CMTA2_HUMAN	Homo sapiens calmodulin binding transcription activator 2 (CAMTA2), transcript variant 4, mRNA.	0					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GGGGAAGCCCTTCCAGCTCCT	0.612000													16	49					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88536863	88536863	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:88536863A>G	uc003hqu.3	+	4	3169	c.3049A>G	c.(3049-3051)Aat>Gat	p.N1017D		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	Homo sapiens dentin sialophosphoprotein (DSPP), mRNA.	1017	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		tgatagcagtaatagtagtga	0.512000													6	142					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141352597	141352597	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr7:141352597G>C	uc003vwi.2	+	15	1313	c.1142G>C	c.(1141-1143)gGc>gCc	p.G381A		NM_018238	NP_060708	Q53H12	AGK_HUMAN	Homo sapiens acylglycerol kinase (AGK), nuclear gene encoding mitochondrial protein, mRNA.	381					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	ATP binding|NAD+ kinase activity|acylglycerol kinase activity|diacylglycerol kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					GGAGCAGGGGGCTCTTTTAGC	0.502000													71	79					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45748333	45748333	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr22:45748333G>T	uc003bgc.3	-	21	3475	c.3423C>A	c.(3421-3423)caC>caA	p.H1141Q	SMC1B_uc003bgd.3_Intron	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	Homo sapiens structural maintenance of chromosomes 1B (SMC1B), mRNA.	1141	Ala/Asp-rich (DA-box).				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding	p.H1143Q(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GACCTTACCTGTGCACAGCAA	0.443000													25	64					8.58068e-18	9.31617e-18	1	1	0
C8orf80	389643	broad.mit.edu	37	8	27913490	27913490	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr8:27913490T>G	uc003xgm.4	-	9	1341	c.1198A>C	c.(1198-1200)Aaa>Caa	p.K400Q		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	Homo sapiens chromosome 8 open reading frame 80 (C8orf80), mRNA.	400						nucleus	GTP binding|GTPase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|skin(1)|stomach(1)	35		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		ACCTTCAGTTTTTCCTTGAGA	0.373000													9	18					0	0	1	0	0
C5orf44	80006	broad.mit.edu	37	5	64956553	64956553	+	Nonsense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr5:64956553T>G	uc003jua.4	+	9	1056	c.726T>G	c.(724-726)taT>taG	p.Y242*	C5orf44_uc003jtz.4_Nonsense_Mutation_p.Y242*|C5orf44_uc010iwv.3_Nonsense_Mutation_p.Y236*|C5orf44_uc003juc.4_Nonsense_Mutation_p.Y236*	NM_001093755	NP_001087224	A5PLN9	CE044_HUMAN	Homo sapiens chromosome 5 open reading frame 44 (C5orf44), transcript variant 1, mRNA.	242										kidney(4)|large_intestine(2)|lung(1)|ovary(1)	8						CAAGAGCATATTTGCAACCAA	0.408000													61	110					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84644467	84644467	+	Silent	SNP	A	A	G	rs149512713	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr7:84644467A>G	uc003uic.3	-	13	1651	c.1611T>C	c.(1609-1611)taT>taC	p.Y537Y	SEMA3D_uc010led.3_Silent_p.Y537Y|SEMA3D_uc003uib.3_Silent_p.Y176Y	NM_152754	NP_689967	O95025	SEM3D_HUMAN	Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D), mRNA.	537	PSI.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AAGCTTTCCCATAAGTGTCGC	0.468000													6	217					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641648	36641648	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr20:36641648G>C	uc002xhl.3	-	2	780	c.571C>G	c.(571-573)Cca>Gca	p.P191A	TTI1_uc002xhm.3_Missense_Mutation_p.P191A	NM_014657	NP_055472	O43156	TTI1_HUMAN	Homo sapiens TELO2 interacting protein 1 (TTI1), mRNA.	191							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AATGACCTTGGATGGTCCTGA	0.423000													20	39					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20457305	20457305	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr22:20457305C>G	uc002zsd.4	-	0	4482	c.3997G>C	c.(3997-3999)Gag>Cag	p.E1333Q	RN7SK_uc021wlw.1_5'Flank	NM_015672	NP_056487			Homo sapiens RIMS binding protein 3 (RIMBP3), mRNA.											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			GGCCCACACTCGGTGCGTAGA	0.577000													9	474					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2130440	2130440	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr19:2130440G>A	uc002lva.3	-	5	782	c.559C>T	c.(559-561)Cgg>Tgg	p.R187W	AP3D1_uc002luy.3_Intron|AP3D1_uc002luz.3_Missense_Mutation_p.R187W	NM_003938	NP_003929	O14617	AP3D1_HUMAN	Homo sapiens adaptor-related protein complex 3, delta 1 subunit (AP3D1), transcript variant 2, mRNA.	187					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	Golgi membrane|endosome membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTCAGCCGGGGAAAGGCA	0.597000													5	82					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225688235	225688235	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:225688235C>T	uc010fwz.1	-	27	3405	c.3166G>A	c.(3166-3168)Gtt>Att	p.V1056I	DOCK10_uc002vob.2_Missense_Mutation_p.V1050I	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	Homo sapiens dedicator of cytokinesis 10 (DOCK10), mRNA.	1056							GTP binding	p.V1054F(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AATCTGGCAACGCTGTGGTTT	0.413000													90	74					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85279278	85279278	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:85279278A>G	uc001szv.3	-	3	1003	c.510T>C	c.(508-510)tcT>tcC	p.S170S	SLC6A15_uc010sul.2_Silent_p.S63S|SLC6A15_uc001szy.3_Silent_p.S170S	NM_182767	NP_001139807	Q9H2J7	S6A15_HUMAN	Homo sapiens solute carrier family 6 (neutral amino acid transporter), member 15 (SLC6A15), transcript variant 1, mRNA.	170					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GAAAAGACTGAGAAAAATAAA	0.368000													39	110					0	0	1	0	0
ETV5	2119	broad.mit.edu	37	3	185797727	185797727	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:185797727C>G	uc003fpy.3	-	6	720	c.655G>C	c.(655-657)Gcc>Ccc	p.A219P	ETV5_uc003fpz.3_Missense_Mutation_p.A177P	NM_004454	NP_004445	P41161	ETV5_HUMAN	Homo sapiens ets variant 5 (ETV5), mRNA.	177					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			GAATGGGGGGCGGGGGCGGGG	0.622000			T	"""TMPRSS2, SCL45A3"""	Prostate								5	23					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572781	30572781	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr6:30572781G>A	uc003nqn.1	-	10	1496	c.944C>T	c.(943-945)aCg>aTg	p.T315M	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 10 (PPP1R10), mRNA.	315	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|RNA binding|protein phosphatase inhibitor activity|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CTTGGCAGCCGTAGGTGACAG	0.468000													22	47					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58292369	58292369	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:58292369G>C	uc002ene.3	+	3	567	c.488G>C	c.(487-489)gGg>gCg	p.G163A	CCDC113_uc010vid.2_Missense_Mutation_p.G109A	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	Homo sapiens coiled-coil domain containing 113 (CCDC113), transcript variant 1, mRNA.	163						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						AAGAAGAAAGGGAGTATTTTG	0.418000													43	55					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784433	82784433	+	Silent	SNP	T	T	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr7:82784433T>C	uc003uhx.2	-	1	1813	c.1524A>G	c.(1522-1524)aaA>aaG	p.K508K	PCLO_uc003uhv.2_Silent_p.K508K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	454	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.K508K(3)|p.K454K(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGGTGGGGGTTTTGTTGAGC	0.607000													4	57					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:39274087G>C	uc002hvz.3	-	0	520	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(2)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	105					0	0	1	0	0
ANKRD34C	390616	broad.mit.edu	37	15	79587095	79587095	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr15:79587095G>A	uc002bet.3	+	1	1938	c.1469G>A	c.(1468-1470)gGc>gAc	p.G490D	ANKRD34C_uc021srm.1_Missense_Mutation_p.G490D	NM_001146341	NP_001139813			Homo sapiens ankyrin repeat domain 34C (ANKRD34C), mRNA.											endometrium(3)|kidney(1)|skin(1)	5						CTTGCTAGTGGCTTAAAATCT	0.428000													16	32					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33772567	33772567	+	Missense_Mutation	SNP	T	T	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:33772567T>C	uc002hjk.1	-	0	463	c.133A>G	c.(133-135)Aga>Gga	p.R45G	SLFN13_uc010wch.1_Missense_Mutation_p.R45G|SLFN13_uc002hjl.2_Missense_Mutation_p.R45G|SLFN13_uc002hjm.2_5'UTR|SLFN13_uc010ctt.2_Intron	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	Homo sapiens schlafen family member 13 (SLFN13), mRNA.	45						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CGTATAACTCTCGCCCTCTCT	0.498000													37	35					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43659419	43659419	+	Missense_Mutation	SNP	G	G	T	rs80035763	byFrequency	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr10:43659419G>T	uc001jan.3	+	4	1421	c.1086G>T	c.(1084-1086)ttG>ttT	p.L362F		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	Homo sapiens chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2), mRNA.	362					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding	p.L362F(10)		endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GAGAGGTCTTGATGTTTTTCT	0.433000													4	100					2.56e-06	2.67743e-06	1	1	0
STXBP3	6814	broad.mit.edu	37	1	109338856	109338856	+	Splice_Site	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:109338856G>C	uc001dvy.3	+	14	1186	c.1111_splice	c.e14-1	p.D371_splice		NM_007269	NP_009200	O00186	STXB3_HUMAN	Homo sapiens syntaxin binding protein 3 (STXBP3), mRNA.	371					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTCATTAAGGACCTGGCACT	0.358000													36	108					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12639471	12639471	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr19:12639471G>T	uc002mty.3	-	1	253	c.43C>A	c.(43-45)Ctt>Att	p.L15I	ZNF709_uc002mtx.4_Intron	NM_144976	NP_659413	Q8N972	ZN709_HUMAN	Homo sapiens zinc finger protein 564 (ZNF564), mRNA.	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CACTCCTCAAGTGTGAAGTTC	0.468000													15	59					5.01169e-05	5.05605e-05	1	1	0
TPTE	7179	broad.mit.edu	37	21	11014937	11014937	+	Splice_Site	SNP	C	C	T	rs76467559	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr21:11014937C>T	uc002yis.1	-	7		c.1508_splice	c.e7+1					P56180	TPTE_HUMAN	Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 2, mRNA.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGCACAATACCTATCACATT	0.328000													4	66					0	0	1	0	0
DHRS4	10901	broad.mit.edu	37	14	24438063	24438063	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr14:24438063A>C	uc001wla.3	+	7	853	c.820A>C	c.(820-822)Acc>Ccc	p.T274P	DHRS4_uc021rrd.1_5'Flank|DHRS4_uc001wlb.3_Missense_Mutation_p.T240P|DHRS4_uc010akz.3_Missense_Mutation_p.T195P|DHRS4_uc001wld.4_Intron|DHRS4_uc001wle.4_Intron|DHRS4_uc001wlc.4_Intron|DHRS4L2_uc001wlf.3_5'Flank|DHRS4L2_uc021rra.1_5'Flank|DHRS4_uc021rrb.1_5'Flank|DHRS4_uc021rrc.1_5'Flank|DHRS4_uc021rre.1_5'Flank	NM_021004	NP_066284	Q9BTZ2	DHRS4_HUMAN	Homo sapiens dehydrogenase/reductase (SDR family) member 4 (DHRS4), mRNA.	274						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	GGGTGGAGGAACCCCGTCCCG	0.607000													5	81					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63990576	63990576	+	Missense_Mutation	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr11:63990576G>T	uc001nyl.2	+	13	1888	c.1739G>T	c.(1738-1740)cGc>cTc	p.R580L	FERMT3_uc001nym.2_Missense_Mutation_p.R576L	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	Homo sapiens fermitin family member 3 (FERMT3), transcript variant URP2LF, mRNA.	580					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding	p.R580C(1)		breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CGACTGATCCGCATCGACTTG	0.622000													51	79					1.74971e-23	1.91795e-23	1	1	0
MUC2	4583	broad.mit.edu	37	11	1093314	1093314	+	Silent	SNP	A	A	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr11:1093314A>T	uc001lsx.1	+	30	5160	c.5133A>T	c.(5131-5133)ccA>ccT	p.P1711P		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1751	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding	p.T1711M(1)|p.T1710T(1)		NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ccccaaccccaacacccaccg	0.637000													4	97					0	0	1	0	0
RNF208	727800	broad.mit.edu	37	9	140115401	140115401	+	Silent	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr9:140115401T>G	uc004clz.2	-	0	375	c.264A>C	c.(262-264)gcA>gcC	p.A88A		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	Homo sapiens ring finger protein 208 (RNF208), mRNA.	88							zinc ion binding			lung(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGGTATGGGGTGCCCCTTCCA	0.652000													4	20					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	353963	353963	+	Silent	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr5:353963C>T	uc003jav.3	+	2	236	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L	AHRR_uc003jaw.3_Silent_p.L65L|AHRR_uc010isy.3_Intron|AHRR_uc010isz.3_Silent_p.L61L	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	Homo sapiens aryl-hydrocarbon receptor repressor (AHRR), transcript variant 1, mRNA.	65	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.L61V(2)		breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CATCTCCAAGCTGGACAAGCT	0.592000													52	92					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	171969140	171969140	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:171969140T>A	uc003fhy.3	+	5	771	c.599T>A	c.(598-600)aTc>aAc	p.I200N	FNDC3B_uc003fhz.4_Missense_Mutation_p.I200N|FNDC3B_uc003fia.3_Missense_Mutation_p.I131N	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	Homo sapiens fibronectin type III domain containing 3B (FNDC3B), transcript variant 1, mRNA.	200						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GACCGCCAGATCGATCGCCAG	0.463000													70	48					0	0	1	0	0
PARL	55486	broad.mit.edu	37	3	183558378	183558378	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:183558378A>G	uc003fmd.3	-	6	867	c.808T>C	c.(808-810)Tat>Cat	p.Y270H	PARL_uc003fme.3_Missense_Mutation_p.Y220H	NM_018622	NP_061092	Q9H300	PARL_HUMAN	Homo sapiens presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	270					proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity			endometrium(2)|large_intestine(3)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	17	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GATGGTCCATATCTTCCTGTG	0.279000													46	87					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606232	21606232	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr19:21606232A>C	uc002npw.3	+	3	890	c.771A>C	c.(769-771)agA>agC	p.R257S	ZNF493_uc002npx.3_Missense_Mutation_p.R129S|ZNF493_uc002npy.3_Missense_Mutation_p.R129S|ZNF493_uc021urq.1_Missense_Mutation_p.R129S	NM_001076678	NP_787106	Q6ZR52	ZN493_HUMAN	Homo sapiens zinc finger protein 493 (ZNF493), transcript variant 3, mRNA.	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CACATAAGAGAATTCATACTG	0.378000													32	27					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821404	5821404	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chrX:5821404T>G	uc010ndi.3	-	5	1890	c.1426A>C	c.(1426-1428)Acc>Ccc	p.T476P	NLGN4X_uc004crp.3_Missense_Mutation_p.T459P|NLGN4X_uc010ndh.3_Missense_Mutation_p.T439P|NLGN4X_uc004crq.3_Missense_Mutation_p.T439P|NLGN4X_uc004crr.3_Missense_Mutation_p.T439P|NLGN4X_uc010ndj.3_Missense_Mutation_p.T439P	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	Homo sapiens neuroligin 4, X-linked (NLGN4X), transcript variant 2, mRNA.	439					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GCCACCAGGGTTTTCCGCCGC	0.597000													5	74					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133359035	133359035	+	Silent	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:133359035C>T	uc001ukz.1	-	16	3871	c.3312G>A	c.(3310-3312)gaG>gaA	p.E1104E	GOLGA3_uc021rgt.1_Non-coding_Transcript|GOLGA3_uc001ula.1_Silent_p.E1104E	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Homo sapiens golgin A3 (GOLGA3), transcript variant 1, mRNA.	1104					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGTTTGACTCCTCAAGGCGTT	0.473000													4	146					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39878312	39878312	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:39878312C>T	uc009vvt.1	+	0	3137	c.2375C>T	c.(2374-2376)tCa>tTa	p.S792L	MACF1_uc021ols.1_Intron|MACF1_uc001cdc.2_Intron|MACF1_uc021olt.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc021olw.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	Homo sapiens KIAA0754 (KIAA0754), mRNA.	656	Ala-rich.									central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGGCATCATCAGAGGGAGGG	0.428000													15	36					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41798200	41798200	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr15:41798200G>T	uc001zoa.3	-	11	1723	c.1545C>A	c.(1543-1545)gcC>gcA	p.A515A	LTK_uc001zob.3_Silent_p.A454A|LTK_uc010ucx.1_Intron|LTK_uc010bcg.2_Silent_p.A213A	NM_002344	NP_002335	P29376	LTK_HUMAN	Homo sapiens leukocyte receptor tyrosine kinase (LTK), transcript variant 1, mRNA.	515	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CATGGCCCAGGGCTCTGCAGG	0.597000										TSP Lung(18;0.14)			50	58					3.74213e-36	4.18238e-36	1	1	0
KRT13	3860	broad.mit.edu	37	17	39661375	39661375	+	Missense_Mutation	SNP	T	T	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:39661375T>A	uc002hwu.1	-	0	491	c.428A>T	c.(427-429)cAg>cTg	p.Q143L	KRT13_uc002hwv.1_Missense_Mutation_p.Q143L|KRT13_uc010wfr.2_Missense_Mutation_p.Q36L|KRT13_uc010cxo.3_Missense_Mutation_p.Q143L|KRT13_uc021txk.1_Missense_Mutation_p.Q36L	NM_153490	NP_705694	P13646	K1C13_HUMAN	Homo sapiens keratin 13 (KRT13), transcript variant 1, mRNA.	143	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				AGCTGGGCTCTGCTTCAGGTG	0.617000													121	73					0	0	1	0	0
KIAA0564	23078	broad.mit.edu	37	13	42185853	42185853	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr13:42185853G>C	uc001uyj.3	-	38	4806	c.4736C>G	c.(4735-4737)gCa>gGa	p.A1579G		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	Homo sapiens KIAA0564 (KIAA0564), transcript variant 1, mRNA.	1579						extracellular region	ATP binding|ATPase activity			endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(19)|lung(15)|ovary(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		ACCCAGGCCTGCCGTGTCTCT	0.522000													24	59					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31091558	31091558	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr14:31091558C>T	uc001wqm.1	+	0	38	c.14C>T	c.(13-15)gCg>gTg	p.A5V	SCFD1_uc001wqn.1_5'UTR|SCFD1_uc010tpg.1_5'UTR|SCFD1_uc010tph.1_5'UTR|SCFD1_uc010amf.1_5'UTR|SCFD1_uc010tpi.1_5'UTR|SCFD1_uc010amd.1_5'UTR	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	Homo sapiens sec1 family domain containing 1 (SCFD1), transcript variant 1, mRNA.	5	Poly-Ala.				post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	Golgi cisterna membrane|Golgi-associated vesicle|cis-Golgi network|endoplasmic reticulum membrane|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		gcggcggcggcggcagcgaca	0.652000													6	11					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172195862	172195862	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:172195862A>G	uc010zdo.2	-	3	579	c.438T>C	c.(436-438)tgT>tgC	p.C146C	METTL8_uc002ugu.4_Silent_p.C146C|METTL8_uc002ugt.4_Silent_p.C146C|METTL8_uc002ugs.4_Silent_p.C96C|METTL8_uc010zdp.2_Silent_p.C101C	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	Homo sapiens methyltransferase like 8 (METTL8), mRNA.	146							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						GCACAGTAGGACAGTGCATTC	0.368000													17	61					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56814422	56814422	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:56814422T>G	uc001slf.2	-	25	3327	c.3159A>C	c.(3157-3159)gaA>gaC	p.E1053D		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	Homo sapiens timeless homolog (Drosophila) (TIMELESS), mRNA.	1053					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TTTCCATGGCTTCCTCATTTT	0.507000													107	114					0	0	1	0	0
AIFM2	84883	broad.mit.edu	37	10	71874678	71874678	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr10:71874678G>A	uc010qjg.2	-	6	984	c.968C>T	c.(967-969)cCg>cTg	p.P323L	AIFM2_uc021psi.1_Missense_Mutation_p.P323L|AIFM2_uc001jqp.2_Missense_Mutation_p.P323L	NM_001198696	NP_001185625	Q9BRQ8	AIFM2_HUMAN	Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 2 (AIFM2), transcript variant 1, mRNA.	323					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|urinary_tract(2)	16						TCTCTTACCCGGCTTGTAGGC	0.547000													15	36					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113140459	113140459	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr13:113140459C>G	uc001vse.1	-	21	2759	c.2572G>C	c.(2572-2574)Gtg>Ctg	p.V858L	TUBGCP3_uc010tjq.1_Missense_Mutation_p.V848L	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	Homo sapiens tubulin, gamma complex associated protein 3 (TUBGCP3), mRNA.	858					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AACTGCTGCACGATACCCTAA	0.458000													79	91					0	0	1	0	0
FAM186A	121006	broad.mit.edu	37	12	50746424	50746424	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:50746424C>G	uc001rwl.2	-	3	4329	c.4191G>C	c.(4189-4191)atG>atC	p.M1397I	FAM186A_uc010smt.1_Missense_Mutation_p.M1175I	NM_001145475	NP_001138947	A6NE01	F186A_HUMAN	Homo sapiens family with sequence similarity 186, member A (FAM186A), mRNA.	1397																	TGGTGAGAGGCATCCCCAAGG	0.637000													5	197					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131735460	131735460	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr9:131735460A>G	uc004bws.1	+	11	1157	c.1135A>G	c.(1135-1137)Atg>Gtg	p.M379V		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	Homo sapiens nucleoporin 188kDa (NUP188), mRNA.	379					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						CACTGCATGCATGTGTGTCTA	0.493000													13	31					0	0	1	0	0
OSGEP	55644	broad.mit.edu	37	14	20922825	20922825	+	Silent	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr14:20922825A>C	uc001vxf.3	-	0	443	c.18T>G	c.(16-18)ggT>ggG	p.G6G	APEX1_uc001vxg.3_5'Flank|APEX1_uc001vxh.3_5'Flank|APEX1_uc001vxi.3_5'Flank|APEX1_uc021rnr.1_5'Flank	NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	Homo sapiens O-sialoglycoprotein endopeptidase (OSGEP), mRNA.	6					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(4)|stomach(1)	11	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		TGCCTTCAAAACCCAGCACCG	0.652000													7	86					0	0	1	0	0
FAM186A	121006	broad.mit.edu	37	12	50747102	50747102	+	Silent	SNP	A	A	G	rs138883430	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:50747102A>G	uc001rwl.2	-	3	3651	c.3513T>C	c.(3511-3513)ctT>ctC	p.L1171L	FAM186A_uc010smt.1_Silent_p.L949L	NM_001145475	NP_001138947	A6NE01	F186A_HUMAN	Homo sapiens family with sequence similarity 186, member A (FAM186A), mRNA.	1171								p.L1171L(2)									GCTGAGGGGTAAGAGGGATCC	0.642000													4	85					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58292370	58292370	+	Silent	SNP	G	G	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:58292370G>T	uc002ene.3	+	3	568	c.489G>T	c.(487-489)ggG>ggT	p.G163G	CCDC113_uc010vid.2_Silent_p.G109G	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	Homo sapiens coiled-coil domain containing 113 (CCDC113), transcript variant 1, mRNA.	163						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						AGAAGAAAGGGAGTATTTTGG	0.413000													42	56					4.0306e-16	4.33479e-16	1	1	0
PLEKHM2	23207	broad.mit.edu	37	1	16053577	16053577	+	Missense_Mutation	SNP	A	A	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:16053577A>C	uc010obo.2	+	8	1237	c.1010A>C	c.(1009-1011)cAc>cCc	p.H337P		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	Homo sapiens pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), mRNA.	337					Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGTCCACTCCACCCCGCCTGC	0.572000													6	145					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172195861	172195861	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:172195861G>A	uc010zdo.2	-	3	580	c.439C>T	c.(439-441)Cct>Tct	p.P147S	METTL8_uc002ugu.4_Missense_Mutation_p.P147S|METTL8_uc002ugt.4_Missense_Mutation_p.P147S|METTL8_uc002ugs.4_Missense_Mutation_p.P97S|METTL8_uc010zdp.2_Missense_Mutation_p.P102S	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	Homo sapiens methyltransferase like 8 (METTL8), mRNA.	147							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						GGCACAGTAGGACAGTGCATT	0.368000													17	63					0	0	1	0	0
TIMM17B	10245	broad.mit.edu	37	X	48751030	48751030	+	Missense_Mutation	SNP	G	G	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chrX:48751030G>C	uc004dla.2	-	7	800	c.651C>G	c.(649-651)agC>agG	p.S217R	TIMM17B_uc004dlc.2_Missense_Mutation_p.S167R	NM_001167947	NP_001161419	O60830	TI17B_HUMAN	Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast) (TIMM17B), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	167					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6						ACTGCTGATAGCTGGGGTAGC	0.632000													24	49					0	0	1	0	0
TPRX1	284355	broad.mit.edu	37	19	48305819	48305819	+	Missense_Mutation	SNP	C	C	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr19:48305819C>G	uc002php.2	-	1	589	c.449G>C	c.(448-450)cGt>cCt	p.R150P		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	Homo sapiens tetra-peptide repeat homeobox 1 (TPRX1), mRNA.	150	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|skin(1)	18		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		gattgggccacggaatgggcc	0.637000													4	72					0	0	1	0	0
SCRN2	90507	broad.mit.edu	37	17	45918192	45918192	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:45918192A>G	uc002imd.3	-	1	144	c.18T>C	c.(16-18)ccT>ccC	p.P6P	SCRN2_uc002imf.3_Silent_p.P6P	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	Homo sapiens secernin 2 (SCRN2), transcript variant 1, mRNA.	6					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						ATGGGGAGTCAGGGCTCGACG	0.662000													39	151					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290624	132290624	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:132290624A>G	uc002tta.3	+	6	1041	c.989A>G	c.(988-990)aAg>aGg	p.K330R	CCDC74A_uc002ttb.3_Missense_Mutation_p.K264R|CCDC74A_uc021vpq.1_Missense_Mutation_p.R266G|CCDC74A_uc021vpr.1_Missense_Mutation_p.K327R	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	Homo sapiens coiled-coil domain containing 74A (CCDC74A), mRNA.	330										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						GTCTCCACCAAGAGCCTCTCC	0.637000													125	195					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161482	220161482	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr2:220161482C>T	uc002vkz.3	-	15	2540	c.2299G>A	c.(2299-2301)Gcc>Acc	p.A767T	PTPRN_uc010zlc.2_Missense_Mutation_p.A677T|PTPRN_uc002vla.3_Missense_Mutation_p.A738T|MIR153-1_uc010zld.1_5'Flank	NM_002846	NP_001186693	Q16849	PTPRN_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), transcript variant 1, mRNA.	767	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		ATGGGGCTGGCGTTGATGTAA	0.607000													36	119					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871576	51871576	+	Missense_Mutation	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr20:51871576G>A	uc002xwo.3	+	1	2466	c.1579G>A	c.(1579-1581)Gcc>Acc	p.A527T	TSHZ2_uc021wex.1_Missense_Mutation_p.A524T	NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	Homo sapiens teashirt zinc finger homeobox 2 (TSHZ2), transcript variant 1, mRNA.	527					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGTCACCACAGCCATCAACAA	0.522000													20	36					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5567473	5567473	+	Missense_Mutation	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr7:5567473A>G	uc003sot.4	-	5	1118	c.1034T>C	c.(1033-1035)aTc>aCc	p.I345T	ACTB_uc003sor.4_Missense_Mutation_p.I223T|ACTB_uc003soq.4_Missense_Mutation_p.I223T	NM_001101	NP_001092	P60709	ACTB_HUMAN	Homo sapiens actin, beta (ACTB), mRNA.	345					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	MLL5-L complex|NuA4 histone acetyltransferase complex|cytoskeleton|cytosol|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CGAGGCCAGGATGGAGCCGCC	0.612000													174	168					0	0	1	0	0
IFNAR1	3454	broad.mit.edu	37	21	34725063	34725063	+	Splice_Site	SNP	G	G	A			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr21:34725063G>A	uc002yrn.3	+	9	1291	c.1144_splice	c.e9-1	p.R382_splice	IFNAR1_uc011adv.2_Splice_Site_p.R313_splice	NM_000629	NP_000620	P17181	INAR1_HUMAN	Homo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1), mRNA.	382	Fibronectin type-III 3.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	ATATTTTCTAGAGAAAAATTA	0.328000													11	4					0	0	1	0	0
UBC	7316	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:21730916G>T	uc002gyy.3	+	1	343	c.218G>T	c.(217-219)cGg>cTg	p.R73L				P0CG48	UBC_HUMAN	SubName: Full=Uncharacterized protein;	225	Ubiquitin-like 1.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|JNK cascade|M/G1 transition of mitotic cell cycle|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|S phase of mitotic cell cycle|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|innate immune response|mRNA metabolic process|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding	p.R73L(24)|p.R72S(1)		breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GTCCTGCGTCGGAGAGGTGGT	0.552000													6	186					5.18039e-06	5.36877e-06	1	1	0
MUC4	4585	broad.mit.edu	37	3	195505867	195505867	+	Missense_Mutation	SNP	A	A	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:195505867A>T	uc021xjp.1	-	1	12740	c.12584T>A	c.(12583-12585)gTc>gAc	p.V4195D	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	958					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.V4195D(6)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGTGTCGGTGACAGGAAGAGG	0.607000													5	90					0	0	1	0	0
SELPLG	6404	broad.mit.edu	37	12	109017408	109017408	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:109017408T>G	uc010sxe.2	-	1	901	c.724A>C	c.(724-726)Acc>Ccc	p.T242P	SELPLG_uc001tni.3_Missense_Mutation_p.T226P|SELPLG_uc021rdm.1_Missense_Mutation_p.T216P|SELPLG_uc001tnh.3_Missense_Mutation_p.T216P	NM_001206609	NP_001193538	Q14242	SELPL_HUMAN	Homo sapiens selectin P ligand (SELPLG), transcript variant 1, mRNA.	226	12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						ATGGCTGTGGTTTGAGTGGTC	0.617000													13	243					0	0	1	0	0
CAPN8	388743	broad.mit.edu	37	1	223717484	223717484	+	Silent	SNP	G	G	A	rs34158997	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:223717484G>A	uc009xee.2	-	15	1735	c.1647C>T	c.(1645-1647)ctC>ctT	p.L549L		NM_001143962	NP_001137434	A6NHC0	CAN8_HUMAN	Homo sapiens calpain 8 (CAPN8), mRNA.	658					proteolysis	Golgi apparatus	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(1)|endometrium(2)|prostate(1)	4						AGTTGATGCCGAGCTTGCTGC	0.572000													3	71					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10099338	10099338	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:10099338A>G	uc021xlv.1	-	4	838	c.555T>C	c.(553-555)atT>atC	p.I185I	WDR1_uc021xlw.1_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	Homo sapiens WD repeat domain 1 (WDR1), transcript variant 1, mRNA.	185			I -> V (in dbSNP:rs13441).		platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CACTTACGCCAATTGTGAACT	0.507000													42	59					0	0	1	0	0
TIMM17B	10245	broad.mit.edu	37	X	48751031	48751031	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chrX:48751031C>T	uc004dla.2	-	7	799	c.650G>A	c.(649-651)aGc>aAc	p.S217N	TIMM17B_uc004dlc.2_Missense_Mutation_p.S167N	NM_001167947	NP_001161419	O60830	TI17B_HUMAN	Homo sapiens translocase of inner mitochondrial membrane 17 homolog B (yeast) (TIMM17B), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	167					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6						CTGCTGATAGCTGGGGTAGCC	0.627000													24	49					0	0	1	0	0
LOC646851	646851	broad.mit.edu	37	22	39032548	39032548	+	Missense_Mutation	SNP	T	T	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr22:39032548T>G	uc011anw.1	-	5	1031	c.427A>C	c.(427-429)Agc>Cgc	p.S143R	LOC646851_uc011anx.1_Missense_Mutation_p.S50R	NM_001013647	NP_001013669	B7Z7C6	B7Z7C6_HUMAN	Homo sapiens putative uncharacterized protein LOC388900 (LOC646851), mRNA.	50																	GGCTTGGAGCTGTTGAAGTTG	0.478000													3	98					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18849889	18849889	+	Silent	SNP	A	A	G			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:18849889A>G	uc002dfm.3	-	42	7431	c.7068T>C	c.(7066-7068)aaT>aaC	p.N2356N	SMG1_uc010bwb.3_Silent_p.N2216N|SMG1_uc010bwa.3_Silent_p.N1087N|SMG1_uc021ted.1_Silent_p.N654N	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	Homo sapiens smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (SMG1), mRNA.	2356	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CAAAGCAAACATTGTAATCTA	0.328000													31	110					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27958364	27958364	+	Missense_Mutation	SNP	C	C	T			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr17:27958364C>T	uc002heo.1	-	14	3767	c.3767G>A	c.(3766-3768)cGc>cAc	p.R1256H	SSH2_uc010wbh.1_Missense_Mutation_p.R1283H	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	Homo sapiens slingshot homolog 2 (Drosophila) (SSH2), mRNA.	1256					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGAAGCTGAGCGCCTCATTTG	0.532000													70	44					0	0	1	0	0
KIAA1751	85452	broad.mit.edu	37	1	1891408	1891409	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:1891408_1891409delGC	uc001aim.1	-	14	1911_1912	c.1755_1756delGC	c.(1753-1758)aagccgfs	p.K585fs	KIAA1751_uc009vkz.1_Frame_Shift_Del_p.K585fs	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	Homo sapiens KIAA1751 (KIAA1751), mRNA.	585										breast(1)|endometrium(5)|kidney(4)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	32	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CTCACCATCGGCTTGAAGGTGA	0.619											OREG0013001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	77	139	---	---	---	---					
UBR4	23352	broad.mit.edu	37	1	19524166	19524172	+	Frame_Shift_Del	DEL	ATTACGA	ATTACGA	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:19524166_19524172delATTACGA	uc001bbi.3	-	6	889_895	c.885_891delTCGTAAT	c.(883-891)gttcgtaatfs	p.V295fs		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA.	295					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CACCTTACCCATTACGAACAGCAGTGG	0.464													28	51	---	---	---	---					
FNDC7	163479	broad.mit.edu	37	1	109265207	109265229	+	Splice_Site	DEL	GAAAACTGGTATGTAAACAAGAG	GAAAACTGGTATGTAAACAAGAG	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr1:109265207_109265229delGAAAACTGGTATGTAAACAAGAG	uc001dvx.3	+	5	856	c.856_splice	c.e5+1	p.V286_splice	FNDC7_uc010ova.2_Splice_Site_p.V53_splice	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	Homo sapiens fibronectin type III domain containing 7 (FNDC7), mRNA.	287	Fibronectin type-III 3.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CAATGACCCTGAAAACTGGTATGTAAACAAGAGTGAGACTGCT	0.439													9	45	---	---	---	---					
UBA6	55236	broad.mit.edu	37	4	68536260	68536261	+	Frame_Shift_Ins	INS	-	-	T	rs140398587	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr4:68536260_68536261insT	uc003hdg.4	-	7	648_649	c.596_597insA	c.(595-597)ttcfs	p.F199fs	UBA6_uc003hdi.3_Frame_Shift_Ins_p.F199fs|UBA6_uc003hdj.2_Frame_Shift_Ins_p.F199fs	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 6 (UBA6), mRNA.	199					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						ATTCATCACCGAAATCACAAAA	0.267													23	73	---	---	---	---					
UBA6	55236	broad.mit.edu	37	4	68536261	68536262	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr4:68536261_68536262insTT	uc003hdg.4	-	7	647_648	c.595_596insAA	c.(595-597)ttcfs	p.F199fs	UBA6_uc003hdi.3_Frame_Shift_Ins_p.F199fs|UBA6_uc003hdj.2_Frame_Shift_Ins_p.F199fs	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 6 (UBA6), mRNA.	199					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TTCATCACCGAAATCACAAAAT	0.272													23	72	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61832051	61832054	+	Frame_Shift_Del	DEL	TTGT	TTGT	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr10:61832051_61832054delTTGT	uc001jky.3	-	36	8923_8926	c.8585_8588delACAA	c.(8584-8589)aacaatfs	p.N2862fs	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2862					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGAGACTTATTGTTAGTGGCTCC	0.402													13	72	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61832057	61832061	+	Frame_Shift_Del	DEL	GTGGC	GTGGC	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr10:61832057_61832061delGTGGC	uc001jky.3	-	36	8916_8920	c.8578_8582delGCCAC	c.(8578-8583)gccactfs	p.A2860fs	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2860					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTTATTGTTAGTGGCTCCCGAACTC	0.415													13	68	---	---	---	---					
THSD1P1	374500	broad.mit.edu	37	13	52857402	52857402	+	RNA	DEL	A	A	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr13:52857402delA	uc001vgm.1	-	2		c.292delT								Homo sapiens thrombospondin, type I, domain containing 1 pseudogene 1 (THSD1P1), non-coding RNA.																		ACTTAACGTCAAAAAAAATGT	0.289													2	4	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72821594	72821602	+	In_Frame_Del	DEL	GCCGCCGCC	GCCGCCGCC	-	rs144525995		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr16:72821594_72821602delGCCGCCGCC	uc002fck.3	-	9	11246_11254	c.10573_10581delGGCGGCGGC	c.(10573-10581)ggcggcggcdel	p.GGG3525del	AK021563_uc002fcj.1_Non-coding_Transcript|ZFHX3_uc002fcl.3_In_Frame_Del_p.GGG2611del	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	3525	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTGGTACGAgccgccgccgccgccgccg	0.689													12	30	---	---	---	---					
ACSS1	84532	broad.mit.edu	37	20	25028726	25028755	+	In_Frame_Del	DEL	GGTGATCCTCACTTCCGTTCCAGGCTCATC	GGTGATCCTCACTTCCGTTCCAGGCTCATC	-	rs144423103		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-10A-01D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	3c59a740-98eb-4a0d-8694-ac30ab89b553	g.chr20:25028726_25028755delGGTGATCCTCACTTCCGTTCCAGGCTCATC	uc002wub.3	-	1	477_506	c.397_426delGATGAGCCTGGAACGGAAGTGAGGATCACC	c.(397-426)gatgagcctggaacggaagtgaggatcaccdel	p.DEPGTEVRIT133del	ACSS1_uc002wuc.3_In_Frame_Del_p.DEPGTEVRIT133del|ACSS1_uc021wbm.1_In_Frame_Del_p.DEPGTEVRIT133del|ACSS1_uc010gdc.3_In_Frame_Del_p.DEPGTEVRIT133del	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	Homo sapiens acyl-CoA synthetase short-chain family member 1 (ACSS1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	133					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	AMP binding|ATP binding|acetate-CoA ligase activity|protein binding	p.D133A(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGTACCTGTAGGTGATCCTCACTTCCGTTCCAGGCTCATCGCGCTCCCAG	0.574													7	58	---	---	---	---					
KIAA1751	85452	broad.mit.edu	37	1	1891408	1891409	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:1891408_1891409delGC	uc001aim.1	-	14	1911_1912	c.1755_1756delGC	c.(1753-1758)aagccgfs	p.K585fs	KIAA1751_uc009vkz.1_Frame_Shift_Del_p.K585fs	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	Homo sapiens KIAA1751 (KIAA1751), mRNA.	585										breast(1)|endometrium(5)|kidney(4)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	32	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CTCACCATCGGCTTGAAGGTGA	0.619											OREG0013001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	77	139	---	---	---	---					
KIF1B	23095	broad.mit.edu	37	1	10425476	10425477	+	Frame_Shift_Ins	INS	-	-	C	rs78662124		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:10425476_10425477insC	uc001aqx.4	+	42	4724_4725	c.4522_4523insC	c.(4522-4524)accfs	p.T1508fs	KIF1B_uc001aqw.4_Frame_Shift_Ins_p.T1462fs|KIF1B_uc001aqy.3_Frame_Shift_Ins_p.T1482fs|KIF1B_uc001aqz.3_Frame_Shift_Ins_p.T1508fs|KIF1B_uc001ara.3_Frame_Shift_Ins_p.T1468fs|KIF1B_uc001arb.3_Frame_Shift_Ins_p.T1494fs	NM_015074	NP_055889	O60333	KIF1B_HUMAN	Homo sapiens kinesin family member 1B (KIF1B), transcript variant 1, mRNA.	1508					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GGTGGAAAAAACCCGCCACTTT	0.505													16	100	---	---	---	---					
UBR4	23352	broad.mit.edu	37	1	19524166	19524172	+	Frame_Shift_Del	DEL	ATTACGA	ATTACGA	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:19524166_19524172delATTACGA	uc001bbi.3	-	6	889_895	c.885_891delTCGTAAT	c.(883-891)gttcgtaatfs	p.V295fs		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA.	295					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CACCTTACCCATTACGAACAGCAGTGG	0.464													28	51	---	---	---	---					
FNDC7	163479	broad.mit.edu	37	1	109265207	109265229	+	Splice_Site	DEL	GAAAACTGGTATGTAAACAAGAG	GAAAACTGGTATGTAAACAAGAG	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr1:109265207_109265229delGAAAACTGGTATGTAAACAAGAG	uc001dvx.3	+	5	856	c.856_splice	c.e5+1	p.V286_splice	FNDC7_uc010ova.2_Splice_Site_p.V53_splice	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	Homo sapiens fibronectin type III domain containing 7 (FNDC7), mRNA.	287	Fibronectin type-III 3.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CAATGACCCTGAAAACTGGTATGTAAACAAGAGTGAGACTGCT	0.439													9	45	---	---	---	---					
FBXO40	51725	broad.mit.edu	37	3	121340335	121340336	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr3:121340335_121340336insC	uc003eeg.2	+	2	269_270	c.59_60insC	c.(58-60)aacfs	p.N20fs		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	Homo sapiens F-box protein 40 (FBXO40), mRNA.	20					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GGATGCTTCAACCGCCACTGCC	0.569													11	249	---	---	---	---					
UBA6	55236	broad.mit.edu	37	4	68536260	68536261	+	Frame_Shift_Ins	INS	-	-	T	rs140398587	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:68536260_68536261insT	uc003hdg.4	-	7	648_649	c.596_597insA	c.(595-597)ttcfs	p.F199fs	UBA6_uc003hdi.3_Frame_Shift_Ins_p.F199fs|UBA6_uc003hdj.2_Frame_Shift_Ins_p.F199fs	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 6 (UBA6), mRNA.	199					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						ATTCATCACCGAAATCACAAAA	0.267													23	73	---	---	---	---					
UBA6	55236	broad.mit.edu	37	4	68536261	68536262	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr4:68536261_68536262insTT	uc003hdg.4	-	7	647_648	c.595_596insAA	c.(595-597)ttcfs	p.F199fs	UBA6_uc003hdi.3_Frame_Shift_Ins_p.F199fs|UBA6_uc003hdj.2_Frame_Shift_Ins_p.F199fs	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 6 (UBA6), mRNA.	199					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TTCATCACCGAAATCACAAAAT	0.272													23	72	---	---	---	---					
TBP	6908	broad.mit.edu	37	6	170871013	170871014	+	In_Frame_Ins	INS	-	-	CAG	rs72320253		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr6:170871013_170871014insCAG	uc003qxu.3	+	2	468_469	c.189_190insCAG	c.(187-192)insCAG	p.95_96insQ	TBP_uc011ehf.2_In_Frame_Ins_p.75_76insQ|TBP_uc003qxt.3_In_Frame_Ins_p.95_96insQ|TBP_uc011ehg.1_In_Frame_Ins_p.95_96insQ	NM_003194	NP_001165556	P20226	TBP_HUMAN	Homo sapiens TATA box binding protein (TBP), transcript variant 1, mRNA.	95	Poly-Gln.		Missing.		cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q63_Q64insQ(1)|p.Q63Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacaacaacagcagcagca	0.550													56	32	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61832051	61832054	+	Frame_Shift_Del	DEL	TTGT	TTGT	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr10:61832051_61832054delTTGT	uc001jky.3	-	36	8923_8926	c.8585_8588delACAA	c.(8584-8589)aacaatfs	p.N2862fs	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2862					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGAGACTTATTGTTAGTGGCTCC	0.402													13	72	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61832057	61832061	+	Frame_Shift_Del	DEL	GTGGC	GTGGC	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr10:61832057_61832061delGTGGC	uc001jky.3	-	36	8916_8920	c.8578_8582delGCCAC	c.(8578-8583)gccactfs	p.A2860fs	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2860					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTTATTGTTAGTGGCTCCCGAACTC	0.415													13	68	---	---	---	---					
MSS51	118490	broad.mit.edu	37	10	75185695	75185695	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr10:75185695delT	uc009xrh.3	-	5	1085	c.1012delA	c.(1012-1014)actfs	p.T338fs	MSS51_uc001juc.3_Frame_Shift_Del_p.T315fs|MSS51_uc001jud.3_Frame_Shift_Del_p.T315fs|MSS51_uc009xrg.3_Frame_Shift_Del_p.T94fs	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	Homo sapiens zinc finger, MYND-type containing 17 (ZMYND17), mRNA.	315							zinc ion binding										AGGGGTGAAGTTGAGGTGCTC	0.542													48	91	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	TAGCTGCTACCTCCGGAGCCA	-	rs66529359	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	uc001sau.1	-	8	1715_1735	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)tatggctccggaggtagcagctac>tac	p.552_559YGSGGSSY>Y	KRT1_uc001sav.1_Splice_Site_p.G556_splice	NM_006121	NP_006112	P04264	K2C1_HUMAN	Homo sapiens keratin 1 (KRT1), mRNA.	552	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.S557_G563delSSYGSGG(6)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						tccggagccgtagctgctacctccggagccatagctgccac	0.688													5	5	---	---	---	---					
PTPRB	5787	broad.mit.edu	37	12	70954544	70954545	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr12:70954544_70954545insC	uc001swb.4	-	14	3714_3715	c.3684_3685insG	c.(3682-3687)cggtttfs	p.R1228fs	PTPRB_uc010sto.2_Frame_Shift_Ins_p.R1138fs|PTPRB_uc010stp.2_Frame_Shift_Ins_p.R1138fs|PTPRB_uc001swc.4_Frame_Shift_Ins_p.R1446fs|PTPRB_uc001swa.4_Frame_Shift_Ins_p.R1358fs|PTPRB_uc001swd.4_Frame_Shift_Ins_p.R1445fs|PTPRB_uc009zrr.2_Frame_Shift_Ins_p.R1325fs	NM_002837	NP_002828	P23467	PTPRB_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 2, mRNA.	1228	Fibronectin type-III 14.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGGCCTTGAAACCGCCACTCCG	0.490													15	215	---	---	---	---					
THSD1P1	374500	broad.mit.edu	37	13	52857402	52857402	+	RNA	DEL	A	A	-			TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr13:52857402delA	uc001vgm.1	-	2		c.292delT								Homo sapiens thrombospondin, type I, domain containing 1 pseudogene 1 (THSD1P1), non-coding RNA.																		ACTTAACGTCAAAAAAAATGT	0.289													2	4	---	---	---	---					
RBL2	5934	broad.mit.edu	37	16	53504046	53504047	+	Frame_Shift_Ins	INS	-	-	C	rs67236350		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:53504046_53504047insC	uc002ehi.4	+	14	2312_2313	c.2194_2195insC	c.(2194-2196)accfs	p.T732fs	RBL2_uc010vgv.1_Frame_Shift_Ins_p.T658fs|RBL2_uc002ehj.3_Frame_Shift_Ins_p.T442fs|RBL2_uc010vgw.2_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	Homo sapiens retinoblastoma-like 2 (p130) (RBL2), mRNA.	732	Pocket; binds E1A.|Spacer.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						CACCATGGCAACCGCCACTGTC	0.520													8	243	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72821594	72821602	+	In_Frame_Del	DEL	GCCGCCGCC	GCCGCCGCC	-	rs144525995		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr16:72821594_72821602delGCCGCCGCC	uc002fck.3	-	9	11246_11254	c.10573_10581delGGCGGCGGC	c.(10573-10581)ggcggcggcdel	p.GGG3525del	AK021563_uc002fcj.1_Non-coding_Transcript|ZFHX3_uc002fcl.3_In_Frame_Del_p.GGG2611del	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	3525	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTGGTACGAgccgccgccgccgccgccg	0.689													12	30	---	---	---	---					
ACSS1	84532	broad.mit.edu	37	20	25028726	25028755	+	In_Frame_Del	DEL	GGTGATCCTCACTTCCGTTCCAGGCTCATC	GGTGATCCTCACTTCCGTTCCAGGCTCATC	-	rs144423103		TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr20:25028726_25028755delGGTGATCCTCACTTCCGTTCCAGGCTCATC	uc002wub.3	-	1	477_506	c.397_426delGATGAGCCTGGAACGGAAGTGAGGATCACC	c.(397-426)gatgagcctggaacggaagtgaggatcaccdel	p.DEPGTEVRIT133del	ACSS1_uc002wuc.3_In_Frame_Del_p.DEPGTEVRIT133del|ACSS1_uc021wbm.1_In_Frame_Del_p.DEPGTEVRIT133del|ACSS1_uc010gdc.3_In_Frame_Del_p.DEPGTEVRIT133del	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	Homo sapiens acyl-CoA synthetase short-chain family member 1 (ACSS1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	133					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	AMP binding|ATP binding|acetate-CoA ligase activity|protein binding	p.D133A(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGTACCTGTAGGTGATCCTCACTTCCGTTCCAGGCTCATCGCGCTCCCAG	0.574													7	58	---	---	---	---					
LZTR1	8216	broad.mit.edu	37	22	21343966	21344002	+	Splice_Site	DEL	GAGGAGGTGAGGGGCGTGGGGAGCCAGGGCGCAGGTA	GAGGAGGTGAGGGGCGTGGGGAGCCAGGGCGCAGGTA	-	rs66577617	by1000genomes	TCGA-A4-A4ZT-01A-11D-A26P-10	TCGA-A4-A4ZT-11A-11D-A26P-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	483bb781-0179-42e1-bf9c-487b240769b8	b72bae06-ad62-4912-a77c-e05d19cbca16	g.chr22:21343966_21344002delGAGGAGGTGAGGGGCGTGGGGAGCCAGGGCGCAGGTA	uc002zto.3	+	7	754	c.651_splice	c.e7+1	p.E217_splice	LZTR1_uc002ztn.3_Splice_Site_p.E176_splice|LZTR1_uc011ahy.2_Splice_Site_p.E198_splice|LZTR1_uc010gsr.1_Splice_Site_p.E88_splice	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	Homo sapiens leucine-zipper-like transcription regulator 1 (LZTR1), mRNA.	217					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CACCTGCTgggaggaggtgaggggcgtggggagccagggcgcaggtagaggaggtga	0.662													7	24	---	---	---	---					
